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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UCN Gene

protein-coding   GIFtS: 53
GCID: GC02M027530

Urocortin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
urocortin1 2
prepro-urocortin1 2
UROC2 5
UI2
Urocortin, Preproprotein2

External Ids:    HGNC: 125161   Entrez Gene: 73492   Ensembl: ENSG000001637947   OMIM: 6009455   UniProtKB: P550893   

Export aliases for UCN gene to outside databases

Previous GC identifers: GC02M027451 GC02M027622 GC02M027504 GC02M027441 GC02M027383 GC02M027273


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UCN Gene:
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally
related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF
type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene
family name similarity, the product of this gene has no sequence similarity to urotensin II. (provided by RefSeq,
Jul 2008)

GeneCards Summary for UCN Gene: 
UCN (urocortin) is a protein-coding gene. Diseases associated with UCN include thyroid medullary carcinoma, and endometrial carcinoma, and among its related super-pathways are cAMP Pathway and G-Beta Gamma Signaling. GO annotations related to this gene include neuropeptide hormone activity and corticotropin-releasing hormone receptor 1 binding.

UniProtKB/Swiss-Prot: UCN1_HUMAN, P55089
Function: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity
to CRF receptor types 1, 2-alpha, and 2-beta

Gene Wiki entry for UCN (Urocortin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UCN gene promoter:
         E2F-3a   E2F-1   E2F   Sp1   NRSF form 1   STAT3   E2F-2   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCN promoter sequence
   Search SABiosciences Chromatin IP Primers for UCN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23-p21   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23-p21

UCN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M027530:  view genomic region     (about GC identifiers)

Start:
27,530,265 bp from pter      End:
27,531,313 bp from pter
Size:
1,049 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UCN1_HUMAN, P55089 (See protein sequence)
Recommended Name: Urocortin precursor  
Size: 124 amino acids; 13458 Da
Subunit: Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain)
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for UCN:
2RMF (3D)        3N96 (3D)    
Secondary accessions: Q6FG64

Explore the universe of human proteins at neXtProt for UCN: NX_P55089

Explore proteomics data for UCN at MOPED 

UCN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

UCN Protein Expression

REFSEQ proteins: NP_003344.1  
ENSEMBL proteins: 
 ENSP00000296099  

Human Recombinant Protein Products for UCN: 
Browse Purified and Recombinant Proteins at EMD Millipore
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Browse OriGene Protein Over-expression Lysates
OriGene Custom MassSpec 
OriGene Custom Protein Services for UCN
GenScript Custom Purified and Recombinant Proteins Services for UCN
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0030424axon ----
GO:0030425dendrite IEA--
GO:0043025neuronal cell body ----
GO:0043196varicosity IEA--

UCN for ontologies           About GeneDecksing



UCN Antibody Products: 
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R&D Systems Antibodies for UCN (Urocortin)
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Novus Biologicals UCN Antibodies
Abcam antibodies for UCN
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ThermoFisher Antibodies for UCN
LSBio Antibodies in human, mouse, rat for UCN 

Assay Products for UCN: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for UCN
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for UCN
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ENDOLIG: Endogenous ligands

3 InterPro protein domains:
 IPR018446 Corticotropin-releasing_fac_CS
 IPR000187 Corticotropin-releasing_factor
 IPR003620 Urocortin_CRF

Graphical View of Domain Structure for InterPro Entry P55089

ProtoNet protein and cluster: P55089

1 Blocks protein domain: IPB000187 Corticotropin-releasing factor

UniProtKB/Swiss-Prot: UCN1_HUMAN, P55089
Similarity: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family


UCN for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: UCN1_HUMAN, P55089
Function: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity
to CRF receptor types 1, 2-alpha, and 2-beta

     Genatlas biochemistry entry for UCN:
urocortin,corticotropin releasing factor family,containing in its 5'utr region the MPV17 gene

     Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001664G-protein coupled receptor binding ----
GO:0005179hormone activity ----
GO:0005184neuropeptide hormone activity TAS8612563
GO:0005515protein binding IPI18234674
GO:0046811histone deacetylase inhibitor activity IEA--
     
UCN for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for UCN:
 Increased cell death in HCC-19 

     4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ucn):
 behavior/neurological  hearing/vestibular/ear  homeostasis/metabolism  nervous system 

UCN for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for UCN: Ucntm1Klee Ucntm1Abas

   inGenious Targeting Laboratory - Custom generated mouse model solutions for UCN 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UCN

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UCN 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UCN 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCN
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UCN
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Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for UCN
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCN

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for UCN
Sirion Biotech Customized adenovirus for overexpression of UCN

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for UCN (see all 4)
OriGene ORF clones in mouse, rat for UCN
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: UCN (NM_003353)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCN
Sirion Biotech Customized lentivirus for stable overexpression of UCN 
                     Customized lentivirus expression plasmids for stable overexpression of UCN 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for UCN
Search LifeMap BioReagents cell lines for UCN
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCN


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for UCN About                                                                                                See pathways by source

SuperPathContained pathways About
1Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA0.77
Activation of PKA through GPCR0.71
cAMP Pathway0.77
2G-Beta Gamma Signaling
CRHR Pathway0.44
3Glucocorticoid Pathway (HPA Axis), Pharmacodynamics
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics
4Adenylate cyclase-activating neuropeptides
Adenylate cyclase-activating neuropeptides

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for UCN
    Adenylate cyclase-activating neuropeptides

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UCN
    Activation of PKA through GPCR
cAMP Pathway
CRHR Pathway
Activation of cAMP-Dependent PKA

1 PharmGKB Pathway for UCN
    Glucocorticoid Pathway (HPA Axis), Pharmacodynamics


UCN for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UCN

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/7 Interacting proteins for UCN (P550893 ENSP000002960994) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
CRHR1P349983, ENSP000003813334I2D: score=4 STRING: ENSP00000381333
CRHBPP243873, ENSP000002743684I2D: score=2 STRING: ENSP00000274368
LEPP411593, ENSP000003126524I2D: score=1 STRING: ENSP00000312652
CRHR2Q133243I2D: score=3 
HDAC4ENSP000002646064STRING: ENSP00000264606
About this table

Gene Ontology (GO): 5/44 biological process terms (GO ID links to tree view) (see all 44):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001934positive regulation of protein phosphorylation ----
GO:0006954inflammatory response IEA--
GO:0006979response to oxidative stress IEA--
GO:0007186G-protein coupled receptor signaling pathway TAS8612563
GO:0007218neuropeptide signaling pathway IEA--

UCN for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

UCN for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UCN (UCN1)

10/29 Novoseek inferred chemical compound relationships for UCN gene (see all 29)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
sauvagine 96.3 68 10375459 (3), 9415408 (3), 10777063 (3), 9326293 (2) (see all 38)
astressin 91.2 19 9449626 (5), 19703147 (2), 10199789 (2), 9886092 (1) (see all 12)
antalarmin 79 2 19703147 (1), 16174714 (1)
acth 57 25 10199789 (5), 9360550 (2), 9533639 (2), 10818395 (1) (see all 11)
cyclic amp 31 3 9628819 (1), 15206947 (1), 10336722 (1)
adenylate 30.7 6 12746280 (2), 12366528 (1), 17952632 (1), 12401516 (1)
forskolin 29.9 2 12810578 (1), 17170072 (1)
dehydroepiandrosterone sulfate 21.1 1 16014403 (1)
sodium cromoglycate 17.8 1 16614391 (1)
charybdotoxin 15.7 1 15721872 (1)

Search CenterWatch for drugs/clinical trials and news about UCN / UCN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UCN gene: 
NM_003353.2  

Unigene Cluster for UCN:

Urocortin
Hs.534363  [show with all ESTs]
Unigene Representative Sequence: BU194700
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000296099(uc002rjp.1)
miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCN
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UCN
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for UCN
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCN
Clone
Products:
     
OriGene clones in human, mouse for UCN (see all 4)
OriGene ORF clones in mouse, rat for UCN
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: UCN (NM_003353)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCN
Sirion Biotech Customized lentivirus for stable overexpression of UCN 
                     Customized lentivirus expression plasmids for stable overexpression of UCN 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for UCN
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UCN
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCN
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCN

Additional mRNA sequence: 

BC104470.1 BC104471.2 CR542244.1 

3 DOTS entries:

DT.97810288  DT.70102959  DT.40195367 

24/39 AceView cDNA sequences (see all 39):

AI631203 AI693759 CA432489 CA430333 AI368662 BE042927 AI206260 AW139263 
AI093441 BU621095 AI382328 AW015145 AI690184 BF115396 BE218419 AI344591 
NM_003353 BM714994 BU619919 CR542244 BE043042 BU634487 BE222804 R66755 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UCN expression in normal human tissues (normalized intensities)      UCN embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGGCAGGCGG
UCN Expression
About this image


UCN expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Neural Tube (Nervous System)
         Mesencephalon
 
 Bone (Muscoskeletal System)

See UCN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UCN

SOURCE GeneReport for Unigene cluster: Hs.534363
    SABiosciences Expression via Pathway-Focused PCR Arrays including UCN: 
          Neurotrophins & Receptors in human mouse rat
          Obesity in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for UCN
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCN
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCN

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for UCN gene from 2/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ucn1 , 5 urocortin1, 5 84.31(n)1
84.87(a)1
  5 (17.11 cM)5
222261  NM_021290.21  NP_067265.11 
 311380635 
zebrafish
(Danio rerio)
Actinopterygii uts16
urotensin 1
22(a)
1 ↔ 1
20(38749238-38752105)


ENSEMBL Gene Tree for UCN (if available)
TreeFam Gene Tree for UCN (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/26 SNPs in UCN are shown (see all 26)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1870504451,2
--27452930(+) AGAACC/TCGAGC 1 -- ds50010--------
rs1424532501,2
--27452940(+) CGTCCC/GAGACC 1 -- ds50010--------
rs789547401,2
--27453087(+) AGGAGC/TGAACT 1 -- ds50010--------
rs1903366311,2
--27453290(+) CCCACA/GCTGCT 1 -- ds50010--------
rs1398052481,2
C--27453404(+) TCTGGG/TGTGGG 1 -- ut310--------
rs283640451,2
C,F,H--27453415(-) GACCCC/TTTTCC 1 -- ut31 ese3 trp36Minor allele frequency- T:0.02NS NA EU 2089
rs283640461,2
C--27531015(-) GCTCAG/AAGCGT 1 -- int11Minor allele frequency- A:0.01--86
rs1140699081,2
F--27531185(+) GAACAT/AGCACT 1 -- us2k11Minor allele frequency- A:0.08WA 118
rs1879058931,2
--27531416(+) CAGACC/TAGACT 1 -- us2k10--------
rs1393605311,2
--27531532(+) CGCTGG/TGCCGC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for UCN (27530265 - 27531313 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for UCN:    About this table     
Variant IDTypeSubtypePubMed ID
nsv873754CNV Loss21882294
nsv833614CNV Gain17160897

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing UCN
DNA2.0 Custom Variant and Variant Library Synthesis for UCN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 600945    OMIM disorders: --

20/37 diseases for UCN (see all 37):    About MalaCards
thyroid medullary carcinoma    endometrial carcinoma    ischemic heart disease    systolic heart failure
allergic asthma    anorexia nervosa    pheochromocytoma    endometriosis
nonsyndromic deafness    gastritis    diabetes insipidus    sensorineural hearing loss
pituitary adenoma    panic disorder    osteoarthritis    multiple endocrine neoplasia
prostate adenocarcinoma    adenoma    asthma    hypoxia

3 diseases from the University of Copenhagen DISEASES database for UCN:
Nonsyndromic deafness     Sensorineural hearing loss     Kidney failure

UCN for disorders           About GeneDecksing

10/34 Novoseek inferred disease relationships for UCN gene (see all 34)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
preterm delivery 22.3 7 19893766 (2), 19619932 (2), 17986644 (1), 16174714 (1)
heart failure 21.2 20 18180061 (3), 15320777 (2), 17506295 (2), 19808377 (2) (see all 10)
preeclampsia 21 9 15924674 (3), 16915033 (2), 18777033 (2), 17083971 (1)
inflammation 19.9 9 11352772 (2), 16427607 (1), 12746287 (1), 11337096 (1) (see all 7)
adrenal tumor 17.7 2 16095756 (1), 15914529 (1)
pheochromocytoma 13.1 2 18480660 (1), 15914529 (1)
ischemia 2.96 11 19660384 (3), 12234964 (1), 17516166 (1), 18180061 (1) (see all 7)
endometriosis 2.49 4 15494048 (3)
miscarriage 2.03 4 12746287 (2), 14602808 (1), 17083971 (1)
heart diseases 1.3 9 14577573 (4), 17258092 (1), 19307705 (1)

Genetic Association Database (GAD): UCN
Human Genome Epidemiology (HuGE) Navigator: UCN (5 documents)

Export disorders for UCN gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for UCN gene, integrated from 9 sources (see all 275):
(articles sorted by number of sources associating them with UCN)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The structures of the mouse and human urocortin genes (Ucn and UCN). (PubMed id 9628819)1, 2, 3, 9 Zhao L.... Vale W.W. (1998)
  2. Cloning and characterization of human urocortin. (PubMed id 8612563)1, 2, 9 Donaldson C.J.... Vale W.W. (1996)
  3. Mutation screening of the urocortin gene: identification of new single nucleotide polymorphisms and association studies with obesity in French Caucasians. (PubMed id 11836334)1, 4, 9 Delplanque J....Froguel P. (2002)
  4. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
  6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  8. [Dynamics of matrix synthesis in molecular biophysics. II. Principle of insertability and the single-valued solution of feedback tasks] (PubMed id 861256)1, 3 Tsarev O.B. (1977)
  9. Urocortin has cell-proliferative effects on cardiac non-myocytes. (PubMed id 12175707)1, 9 Ikeda K....Nakao K. (2002)
  10. Expression of urocortin in the extravillous human trophoblast at the implantation site. (PubMed id 16698078)1, 9 Bamberger C.M....Makrigiannakis A. (2007)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7349 HGNC: 12516 AceView: UCN Ensembl:ENSG00000163794 euGenes: HUgn7349
ECgene: UCN H-InvDB: UCN

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for UCN Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for UCN gene:
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