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Aliases for UCN Gene

Aliases for UCN Gene

  • Urocortin 2 3 3 5
  • Prepro-Urocortin 2 3
  • Urocortin, Preproprotein 3
  • UROC 3
  • UI 3

External Ids for UCN Gene

Previous GeneCards Identifiers for UCN Gene

  • GC02M027451
  • GC02M027622
  • GC02M027504
  • GC02M027441
  • GC02M027383
  • GC02M027530

Summaries for UCN Gene

Entrez Gene Summary for UCN Gene

  • This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]

GeneCards Summary for UCN Gene

UCN (Urocortin) is a Protein Coding gene. Diseases associated with UCN include Ulcerative Colitis and Colitis. Among its related pathways are Activation of cAMP-Dependent PKA and Signaling by GPCR. GO annotations related to this gene include hormone activity and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for UCN Gene

  • Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).

Gene Wiki entry for UCN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCN Gene

Genomics for UCN Gene

Regulatory Elements for UCN Gene

Enhancers for UCN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F027353 0.4 ENCODE 11.2 -45.7 -45721 1.6 ATF1 PKNOX1 CREB3L1 MLX ARID4B DMAP1 ZNF48 SLC30A9 GATA2 SP5 MPV17 ZNF513 UCN TRIM54 NRBP1 KRTCAP3 IFT172 ATRAID SLC5A6 PREB
GH02F027265 0.9 ENCODE 10.5 +43.3 43268 0.2 ARID4B SIN3A ZNF48 ZNF2 GLIS2 KLF7 SP3 YY2 SP5 NFYC SLC5A6 ATRAID UCN MPV17 DNAJC5G CAD
GH02F027091 1.1 Ensembl ENCODE 10.4 +214.3 214331 7.0 CREB3L1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 PAF1 SP5 KHK EMILIN1 ABHD1 CGREF1 ATRAID SLC5A6 CAD PRR30 TCF23 PREB
GH02F027090 0.5 Ensembl 10.4 +218.3 218345 0.2 KHK SLC5A6 ATRAID ABHD1 CGREF1 PREB TRIM54 UCN MPV17 LOC100129724
GH02F027085 1.1 Ensembl ENCODE 10.4 +221.0 220959 4.8 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 KHK SLC5A6 ATRAID ABHD1 CGREF1 PREB TRIM54 UCN MPV17 LOC100129724
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UCN on UCSC Golden Path with GeneCards custom track

Genomic Location for UCN Gene

Chromosome:
2
Start:
27,307,397 bp from pter
End:
27,308,445 bp from pter
Size:
1,049 bases
Orientation:
Minus strand

Genomic View for UCN Gene

Genes around UCN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCN Gene

Proteins for UCN Gene

  • Protein details for UCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55089-UCN1_HUMAN
    Recommended name:
    Urocortin
    Protein Accession:
    P55089
    Secondary Accessions:
    • Q6FG64

    Protein attributes for UCN Gene

    Size:
    124 amino acids
    Molecular mass:
    13458 Da
    Quaternary structure:
    • Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).
    Miscellaneous:
    • Positive correlation between increased expression in colonic lamina propria and severity of inflammation in patients with ulcerative colitis.

    Three dimensional structures from OCA and Proteopedia for UCN Gene

neXtProt entry for UCN Gene

Post-translational modifications for UCN Gene

No Post-translational modifications

Other Protein References for UCN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UCN Gene

Domains & Families for UCN Gene

Gene Families for UCN Gene

Protein Domains for UCN Gene

Suggested Antigen Peptide Sequences for UCN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55089

UniProtKB/Swiss-Prot:

UCN1_HUMAN :
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Family:
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
genes like me logo Genes that share domains with UCN: view

Function for UCN Gene

Molecular function for UCN Gene

GENATLAS Biochemistry:
urocortin,corticotropin releasing factor family,containing in its 5utr region the MPV17 gene
UniProtKB/Swiss-Prot Function:
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).

Gene Ontology (GO) - Molecular Function for UCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
GO:0005184 neuropeptide hormone activity TAS 8612563
GO:0005515 protein binding IPI 18234674
GO:0017045 corticotropin-releasing hormone activity IBA --
GO:0046811 histone deacetylase inhibitor activity IEA --
genes like me logo Genes that share ontologies with UCN: view
genes like me logo Genes that share phenotypes with UCN: view

Animal Models for UCN Gene

MGI Knock Outs for UCN:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for UCN Gene

Localization for UCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCN Gene COMPARTMENTS Subcellular localization image for UCN gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for UCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0030424 axon IEA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with UCN: view

Pathways & Interactions for UCN Gene

genes like me logo Genes that share pathways with UCN: view

Gene Ontology (GO) - Biological Process for UCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0001964 startle response IEA --
GO:0006954 inflammatory response IEA --
GO:0006979 response to oxidative stress IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8612563
genes like me logo Genes that share ontologies with UCN: view

No data available for SIGNOR curated interactions for UCN Gene

Drugs & Compounds for UCN Gene

(23) Drugs for UCN Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urocortin (rat) Pharma Endogenous CRF agonist 0

(7) Additional Compounds for UCN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for UCN Gene

Compound Action Cas Number
Urocortin (rat) 171543-83-2
genes like me logo Genes that share compounds with UCN: view

Transcripts for UCN Gene

mRNA/cDNA for UCN Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(39) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UCN Gene

Urocortin:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCN Gene

No ASD Table

Relevant External Links for UCN Gene

GeneLoc Exon Structure for
UCN
ECgene alternative splicing isoforms for
UCN

Expression for UCN Gene

mRNA expression in normal human tissues for UCN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UCN Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UCN Gene



Protein tissue co-expression partners for UCN Gene

NURSA nuclear receptor signaling pathways regulating expression of UCN Gene:

UCN

SOURCE GeneReport for Unigene cluster for UCN Gene:

Hs.534363

mRNA Expression by UniProt/SwissProt for UCN Gene:

P55089-UCN1_HUMAN
Tissue specificity: Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481).
genes like me logo Genes that share expression patterns with UCN: view

Primer Products

No data available for mRNA differential expression in normal tissues for UCN Gene

Orthologs for UCN Gene

This gene was present in the common ancestor of chordates.

Orthologs for UCN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UCN 34 35
  • 98.12 (n)
cow
(Bos Taurus)
Mammalia UCN 34 35
  • 90.05 (n)
dog
(Canis familiaris)
Mammalia UCN 34 35
  • 88.71 (n)
mouse
(Mus musculus)
Mammalia Ucn 34 16 35
  • 84.31 (n)
rat
(Rattus norvegicus)
Mammalia Ucn 34
  • 83.47 (n)
oppossum
(Monodelphis domestica)
Mammalia UCN 35
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii uts1 35
  • 30 (a)
OneToOne
Species where no ortholog for UCN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UCN Gene

ENSEMBL:
Gene Tree for UCN (if available)
TreeFam:
Gene Tree for UCN (if available)

Paralogs for UCN Gene

No data available for Paralogs for UCN Gene

Variants for UCN Gene

Sequence variations from dbSNP and Humsavar for UCN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs121909722 Pathogenic 27,309,945(-) TGGAA(A/C)TCCTA upstream-variant-2KB, reference, missense
rs267607259 Pathogenic 27,309,958(-) TGTTG(A/C)TGTTA upstream-variant-2KB, reference, missense
rs267607260 Pathogenic 27,309,934(-) CCTGT(C/T)CTGGA upstream-variant-2KB, reference, missense
rs1049751 -- 27,309,757(-) TCACT(C/T)TAAAA upstream-variant-2KB, utr-variant-3-prime
rs1049772 -- 27,309,716(-) ATAGT(C/T)TTATT upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UCN Gene

Variant ID Type Subtype PubMed ID
nsv833614 CNV gain 17160897

Variation tolerance for UCN Gene

Gene Damage Index Score: 0.62; 13.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UCN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UCN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCN Gene

Disorders for UCN Gene

MalaCards: The human disease database

(5) MalaCards diseases for UCN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ulcerative colitis
  • left-sided ulcerative colitis
colitis
nonsyndromic deafness
  • nonsyndromic hearing loss
intestinal disease
  • intestinal diseases
auditory system disease
  • destruction - ear drum
- elite association - COSMIC cancer census association via MalaCards
Search UCN in MalaCards View complete list of genes associated with diseases

Relevant External Links for UCN

Genetic Association Database (GAD)
UCN
Human Genome Epidemiology (HuGE) Navigator
UCN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UCN
genes like me logo Genes that share disorders with UCN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UCN Gene

Publications for UCN Gene

  1. The structures of the mouse and human urocortin genes (Ucn and UCN). (PMID: 9628819) Zhao L. … Vale W.W. (Genomics 1998) 2 3 4 22 64
  2. Mutation screening of the urocortin gene: identification of new single nucleotide polymorphisms and association studies with obesity in French Caucasians. (PMID: 11836334) Delplanque J. … Froguel P. (J. Clin. Endocrinol. Metab. 2002) 3 22 46 64
  3. The skin produces urocortin. (PMID: 10690896) Slominski A. … Wortsman J. (J. Clin. Endocrinol. Metab. 2000) 3 4 22 64
  4. Cloning and characterization of human urocortin. (PMID: 8612563) Donaldson C.J. … Vale W.W. (Endocrinology 1996) 3 4 22 64
  5. Circulating levels of stress associated peptide Urocortin in heart failure patients. (PMID: 19961889) Gruson D. … Rousseau M.F. (Peptides 2010) 3 22 64

Products for UCN Gene

Sources for UCN Gene

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