External Ids for UCN Gene
Previous GeneCards Identifiers for UCN Gene
This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]
GeneCards Summary for UCN Gene
UCN (Urocortin) is a Protein Coding gene. Diseases associated with UCN include Ulcerative Colitis and Colitis. Among its related pathways are G-Beta Gamma Signaling and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. GO annotations related to this gene include hormone activity and neuropeptide hormone activity.
UniProtKB/Swiss-Prot for UCN Gene
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).