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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UCN Gene

protein-coding   GIFtS: 52
GCID: GC02M027530

urocortin

 Explore 35 diseases affiliated with
UCN via our new
 Human Malady Compendium 
Biological research products
for UCN
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Urocortin1
UROC1 2 5
UI1 2
Urocortin, Preproprotein2

External Ids:    HGNC: 125161   Entrez Gene: 73492   Ensembl: ENSG000001637947   OMIM: 6009455   UniProtKB: P550893   

Export aliases for UCN gene to outside databases

Previous GC identifers: GC02M027451 GC02M027622 GC02M027504 GC02M027441 GC02M027383 GC02M027273


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UCN:
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to
the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2
receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name
similarity, the product of this gene has no sequence similarity to urotensin II. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UCN1_HUMAN, P55089
Function: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to
CRF receptor types 1, 2-alpha, and 2-beta

Gene Wiki entry for UCN (Urocortin)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UCN gene promoter:
         E2F-3a   E2F-1   E2F   Sp1   NRSF form 1   STAT3   E2F-2   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCN promoter sequence
   Search SABiosciences Chromatin IP Primers for UCN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23-p21   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23-p21

UCN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M027530:  view genomic region     (about GC identifiers)

Start:
27,530,265 bp from pter      End:
27,531,313 bp from pter
Size:
1,049 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UCN1_HUMAN, P55089 (See protein sequence)
Recommended Name: Urocortin precursor  
Size: 124 amino acids; 13458 Da
Subunit: Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain)
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for UCN:
2RMF (3D)        3N96 (3D)    
Secondary accessions: Q6FG64

Explore the universe of human proteins at neXtProt for UCN: NX_P55089

UCN Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_003344.1  
ENSEMBL proteins: 
 ENSP00000296099   ENSP00000435174  

Human Recombinant Protein Products: 
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OriGene Custom Protein Services for UCN 
GenScript Custom Purified and Recombinant Proteins Services for UCN
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Browse Proteins at Uscn

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0030424axon ----
GO:0030425dendrite IEA--
GO:0043025neuronal cell body ----
GO:0043196varicosity IEA--


UCN for ontologies           About GeneDecksing



UCN Antibody Products: 
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R&D Systems Antibodies for UCN (Urocortin)
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Novus Biologicals UCN Antibodies
Search for Antibodies for UCN at Abcam  
Browse Antibodies at Uscn
ThermoFisher Antibodies for UCN

Assay Products for UCN: 
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OriGene Custom Immunoassay Development
Browse OriGene Fluorogenic Cell Assay Kits
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GenScript Custom Assay Services for UCN
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UCN for domains           About GeneDecksing

3 InterPro domains/families:
 IPR018446 Corticotropin-releasing_fac_CS
 IPR000187 Corticotropin-releasing_factor
 IPR003620 Urocortin_CRF

Graphical View of Domain Structure for InterPro Entry P55089

ProtoNet protein and cluster: P55089

1 Blocks protein family: IPB000187 Corticotropin-releasing factor

UniProtKB/Swiss-Prot: UCN1_HUMAN, P55089
Similarity: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: UCN1_HUMAN, P55089
Function: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to
CRF receptor types 1, 2-alpha, and 2-beta

     Genatlas biochemistry entry for UCN:
urocortin,corticotropin releasing factor family,containing in its 5'utr region the MPV17 gene

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCN
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UCN
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UCN (see all 7)
OriGene shRNA RFP: UCN
OriGene siRNA: UCN
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCN

Gene Editing
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DNA2.0 Custom Protein Engineering Service for UCN

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UCN (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UCN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: UCN (NM_003353)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCN 

Cell Line
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GenScript Custom overexpressing Cell Line Services for UCN
Search LifeMap BioReagents cell lines for UCN

In Situ Assay
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Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UCN

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001664G-protein coupled receptor binding ----
GO:0005184neuropeptide hormone activity TAS8612563
GO:0005515protein binding IPI18234674
GO:0046811histone deacetylase inhibitor activity IEA--
GO:0051430corticotropin-releasing hormone receptor 1 binding IEA--


UCN for ontologies           About GeneDecksing


1 GenomeRNAi human phenotype for UCN:
 Increased cell death in HCC-19 

Animal Models:
     Mouse knock-outs for UCN: Ucntm1Klee Ucntm1Abas
     4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ucn):
 behavior/neurological  hearing/vestibular/ear  homeostasis/metabolism  nervous system 

UCN for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA1.00
Activation of PKA through GPCR0.71
cAMP Pathway0.77
2Glucocorticoid Pathway (HPA Axis), Pharmacodynamics
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics1.00
3Adenylate cyclase-activating neuropeptides
Adenylate cyclase-activating neuropeptides1.00
4G-Beta Gamma Signaling
CRHR Pathway0.44

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for UCN
    Adenylate cyclase-activating neuropeptides

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UCN
    Activation of PKA through GPCR
cAMP Pathway
CRHR Pathway
Activation of cAMP-Dependent PKA

1 PharmGKB Pathway for UCN
    Glucocorticoid Pathway (HPA Axis), Pharmacodynamics


UCN for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UCN

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/7 Interacting proteins for UCN (P550893 ENSP000002960994) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
CRHR1P349983, ENSP000003813334I2D: score=4 STRING: ENSP00000381333
CRHBPP243873, ENSP000002743684I2D: score=2 STRING: ENSP00000274368
LEPP411593, ENSP000003126524I2D: score=1 STRING: ENSP00000312652
CRHR2Q133243I2D: score=3 
HDAC4ENSP000002646064STRING: ENSP00000264606
About this table

Gene Ontology (GO): 5/42 biological process terms (GO ID links to tree view) (see all 42):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006954inflammatory response IEA--
GO:0006979response to oxidative stress IEA--
GO:0007186G-protein coupled receptor signaling pathway TAS8612563
GO:0007218neuropeptide signaling pathway IEA--
GO:0007565female pregnancy IEA--


UCN for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

UCN for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UCN
10/29 Novoseek chemical compound relationships for UCN gene (see all 29)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
sauvagine 96.3 68 10375459 (3), 9415408 (3), 10777063 (3), 9326293 (2) (see all 38)
astressin 91.2 19 9449626 (5), 19703147 (2), 10199789 (2), 9886092 (1) (see all 12)
antalarmin 79 2 19703147 (1), 16174714 (1)
acth 57 25 10199789 (5), 9360550 (2), 9533639 (2), 10818395 (1) (see all 11)
cyclic amp 31 3 9628819 (1), 15206947 (1), 10336722 (1)
adenylate 30.7 6 12746280 (2), 12366528 (1), 17952632 (1), 12401516 (1)
forskolin 29.9 2 12810578 (1), 17170072 (1)
dehydroepiandrosterone sulfate 21.1 1 16014403 (1)
sodium cromoglycate 17.8 1 16614391 (1)
charybdotoxin 15.7 1 15721872 (1)

Search CenterWatch for drugs/clinical trials and news about UCN / UCN1 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UCN gene: 
NM_003353.2  

Unigene Cluster for UCN:

Urocortin
Hs.534363  [show with all ESTs]
Unigene Representative Sequence: BU194700
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000296099(uc002rjp.1) ENST00000526964

miRNA
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Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UCN (see all 7)
OriGene shRNA RFP: UCN
OriGene siRNA: UCN
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCN
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UCN (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UCN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: UCN (NM_003353)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCN 
Primer
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OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UCN
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCN
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCN

Additional cDNA sequence: 

BC104470.1 BC104471.2 CR542244.1 

3 DOTS entries:

DT.97810288  DT.70102959  DT.40195367 

24/39 AceView cDNA sequences (see all 39):

AI382328 BU619919 AI093441 NM_003353 CA432489 BE043042 AI344591 AI631203 
AW015145 BM714994 BE218419 BU621095 BF115396 AI690184 CR542244 BE042927 
AW139263 AI368662 AI693759 AI206260 CA430333 BG752622 BU634487 R66755 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UCN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGCAGGCGG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See UCN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UCN

SOURCE GeneReport for Unigene cluster: Hs.534363
    SABiosciences Expression via Pathway-Focused PCR Arrays including UCN: 
          Neurotrophins & Receptors in human mouse rat
          Obesity in human mouse rat

Primer
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OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UCN
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCN
In Situ
Assay Products:
 

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for UCN

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for UCN gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ucn1 , 5 urocortin1, 5 84.31(n)1
84.87(a)1
  5 (17.11 cM)5
222261  NM_021290.21  NP_067265.11 
 311380635 


ENSEMBL Gene Tree for UCN (if available)
TreeFam Gene Tree for UCN (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/24 NCBI SNPs in UCN are shown (see all 24    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1870504451,2
--27529870(+) AGAACC/TCGAGC 3 -- ds5001 ut310--------
rs1424532501,2
--27529880(+) CGTCCC/GAGACC 3 -- ds5001 ut310--------
rs789547401,2
--27530027(+) AGGAGC/TGAACT 3 -- ds5001 ut310--------
rs1903366311,2
--27530230(+) CCCACA/GCTGCT 3 -- ds5001 ut310--------
rs1398052481,2
C,--27530344(+) TCTGGG/TGTGGG 3 -- ut31 ds50010--------
rs283640451,2
C,F,H,--27530355(-) GACCCC/TTTTCC 3 -- ut31 ds5001 ese3 trp36Minor allele frequency- T:0.02NS NA EU 2089
rs1821060111,2
--27530364(+) TCAACA/GTTTTC 3 -- ut31 ds50010--------
rs1446395851,2
--27530637(+) GCCCC-/GGGGGC 4 PG PRG ds5001 fra10--------
rs283640461,2
C--27531015(-) GCTCAG/AAGCGT 1 -- int11Minor allele frequency- A:0.01--86
rs1140699081,2
F,--27531185(+) GAACAT/AGCACT 1 -- us2k11Minor allele frequency- A:0.08WA 118

HapMap Linkage Disequilibrium report for UCN (27530265 - 27531313 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for UCN: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UCN
DNA2.0 Custom Variant and Variant Library Synthesis for UCN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

UCN for disorders           About GeneDecksing

OMIM gene information: 600945    OMIM disorders: --

20/35 diseases for UCN (see all 35):    About MalaCards
systolic heart failure    anorexia nervosa    multiple endocrine neoplasia    nonsyndromic deafness
spontaneous abortion    pituitary adenoma    ischemic heart disease    thyroid medullary carcinoma
diabetes insipidus    rheumatoid arthritis    allergic asthma    endometrial carcinoma
gastritis    renal cell carcinoma    pheochromocytoma    adenoma
asthma    endometriosis    osteoarthritis    arthritis

2 diseases from the University of Copenhagen DISEASES database for UCN:
Nonsyndromic deafness     Sensorineural hearing loss

10/34 Novoseek disease relationships for UCN gene (see all 34)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
preterm delivery 22.3 7 19893766 (2), 19619932 (2), 17986644 (1), 16174714 (1)
heart failure 21.2 20 18180061 (3), 15320777 (2), 17506295 (2), 19808377 (2) (see all 10)
preeclampsia 21 9 15924674 (3), 16915033 (2), 18777033 (2), 17083971 (1)
inflammation 19.9 9 11352772 (2), 16427607 (1), 12746287 (1), 11337096 (1) (see all 7)
adrenal tumor 17.7 2 16095756 (1), 15914529 (1)
pheochromocytoma 13.1 2 18480660 (1), 15914529 (1)
ischemia 2.96 11 19660384 (3), 12234964 (1), 17516166 (1), 18180061 (1) (see all 7)
endometriosis 2.49 4 15494048 (3)
miscarriage 2.03 4 12746287 (2), 14602808 (1), 17083971 (1)
heart diseases 1.3 9 14577573 (4), 17258092 (1), 19307705 (1)

Genetic Association Database (GAD): UCN
Human Genome Epidemiology (HuGE) Navigator: UCN (5 documents)

Export disorders for UCN gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for UCN gene, integrated from 9 sources (see all 274):
(articles sorted by number of sources associating them with UCN)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The structures of the mouse and human urocortin genes (Ucn and UCN). (PubMed id 9628819)1, 2, 3, 9 Zhao L.... Vale W.W. (1998)
  2. Cloning and characterization of human urocortin. (PubMed id 8612563)1, 2, 9 Donaldson C.J.... Vale W.W. (1996)
  3. Mutation screening of the urocortin gene: identification of new single nucleotide polymorphisms and association studies with obesity in French Caucasians. (PubMed id 11836334)1, 4, 9 Delplanque J....Froguel P. (2002)
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. [Dynamics of matrix synthesis in molecular biophysics. II. Principle of insertability and the single-valued solution of feedback tasks] (PubMed id 861256)1, 3 Tsarev O.B. (1977)
  7. Urocortin has cell-proliferative effects on cardiac non-myocytes. (PubMed id 12175707)1, 9 Ikeda K....Nakao K. (2002)
  8. Expression of urocortin in the extravillous human trophoblast at the implantation site. (PubMed id 16698078)1, 9 Bamberger C.M....Makrigiannakis A. (2007)
  9. Urocortin expression in human pituitary gland and pituitary adenoma. (PubMed id 9360550)1, 9 Iino K....Yoshimi T. (1997)
  10. Expression of urocortin and corticotropin-releasing factor receptor subtypes in the human heart. (PubMed id 11788672)1, 9 Kimura Y....Sasano H. (2002)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7349 HGNC: 12516 AceView: UCN Ensembl:ENSG00000163794 euGenes: HUgn7349
ECgene: UCN H-InvDB: UCN

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for UCN Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
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Patent Information for UCN gene:
Search GeneIP for patents involving UCN

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