Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UCN Gene

protein-coding   GIFtS: 53
GCID: GC02M027530

Urocortin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
urocortin1 2
prepro-urocortin1 2
UROC2 5
UI2
Urocortin, Preproprotein2

External Ids:    HGNC: 125161   Entrez Gene: 73492   Ensembl: ENSG000001637947   OMIM: 6009455   UniProtKB: P550893   

Export aliases for UCN gene to outside databases

Previous GC identifers: GC02M027451 GC02M027622 GC02M027504 GC02M027441 GC02M027383 GC02M027273


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UCN Gene:
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally
related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF
type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene
family name similarity, the product of this gene has no sequence similarity to urotensin II. (provided by RefSeq,
Jul 2008)

GeneCards Summary for UCN Gene:
UCN (urocortin) is a protein-coding gene. Diseases associated with UCN include thyroid medullary carcinoma, and ischemic heart disease. GO annotations related to this gene include neuropeptide hormone activity and corticotropin-releasing hormone receptor 1 binding.

UniProtKB/Swiss-Prot: UCN1_HUMAN, P55089
Function: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity
to CRF receptor types 1, 2-alpha, and 2-beta

Gene Wiki entry for UCN (Urocortin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the UCN gene promoter:
         E2F-3a   E2F-1   E2F   Sp1   NRSF form 1   STAT3   E2F-2   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCN promoter sequence
   Search Chromatin IP Primers for UCN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UCN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23-p21   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23-p21

UCN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M027530:  view genomic region     (about GC identifiers)

Start:
27,530,265 bp from pter      End:
27,531,313 bp from pter
Size:
1,049 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UCN1_HUMAN, P55089 (See protein sequence)
Recommended Name: Urocortin precursor  
Size: 124 amino acids; 13458 Da
Subunit: Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain)
2 PDB 3D structures from and Proteopedia for UCN:
2RMF (3D)        3N96 (3D)    
Secondary accessions: Q6FG64

Explore the universe of human proteins at neXtProt for UCN: NX_P55089

Explore proteomics data for UCN at MOPED


See UCN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003344.1  
ENSEMBL proteins: 
 ENSP00000296099  

UCN Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
OriGene Custom MassSpec
OriGene Custom Protein Services for UCN
GenScript Custom Purified and Recombinant Proteins Services for UCN
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

UCN Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for UCN (Urocortin)
OriGene Antibodies for UCN
OriGene Custom Antibody Services for UCN
Novus Biologicals UCN Antibodies
Abcam antibodies for UCN (P55089, Q6FG64)
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for UCN
LSBio Antibodies in human, mouse, rat for UCN

UCN Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for UCN
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for UCN
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
ENDOLIG: Endogenous ligands

3 InterPro protein domains:
 IPR018446 Corticotropin-releasing_fac_CS
 IPR000187 Corticotropin-releasing_factor
 IPR003620 Urocortin_CRF

Graphical View of Domain Structure for InterPro Entry P55089

ProtoNet protein and cluster: P55089

1 Blocks protein domain: IPB000187 Corticotropin-releasing factor

UniProtKB/Swiss-Prot: UCN1_HUMAN, P55089
Similarity: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family


UCN for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: UCN1_HUMAN, P55089
Function: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity
to CRF receptor types 1, 2-alpha, and 2-beta

     Genatlas biochemistry entry for UCN:
urocortin,corticotropin releasing factor family,containing in its 5'utr region the MPV17 gene

     Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001664G-protein coupled receptor binding ----
GO:0005179hormone activity ----
GO:0005184neuropeptide hormone activity TAS8612563
GO:0005515protein binding IPI18234674
GO:0046811histone deacetylase inhibitor activity IEA--
     
UCN for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for UCN:
 Increased cell death in HCC-19 

     4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ucn):
 behavior/neurological  hearing/vestibular/ear  homeostasis/metabolism  nervous system 

UCN for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for UCN: Ucntm1Klee Ucntm1Abas

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UCN
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UCN

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UCN
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UCN

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat UCN using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate UCN
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for UCN
Predesigned siRNA for gene silencing in human, mouse, rat UCN

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for UCN

Clone
Products:
     
OriGene clones in human, mouse for UCN (see all 5)
OriGene ORF clones in mouse, rat for UCN
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: UCN (NM_003353)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCN

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for UCN
Browse ESI BIO Cell Lines and PureStem Progenitors for UCN 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCN


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
UCN1_HUMAN, P55089: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
mitochondrion3
nucleus2

Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0030424axon ----
GO:0030425dendrite IEA--
GO:0043025neuronal cell body ----
GO:0043196varicosity IEA--

UCN for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for UCN About    
See pathways by source

SuperPathContained pathways About
1Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA0.77
Activation of PKA through GPCR0.71
cAMP Pathway0.77
2G-Beta Gamma Signaling
CRHR Pathway0.44
3Glucocorticoid Pathway (HPA Axis), Pharmacodynamics
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics
4Adenylate cyclase activating neuropeptides
Adenylate cyclase activating neuropeptides

4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UCN
    Activation of PKA through GPCR
cAMP Pathway
CRHR Pathway
Activation of cAMP-Dependent PKA

1 PharmGKB Pathway for UCN
    Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

    Pathway & Disease-focused RT2 Profiler PCR Arrays including UCN: 
          Neurotrophins & Receptors in human mouse rat
          Obesity in human mouse rat

Interactions:

    GeneGlobe Interaction Network for UCN

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

Selected Interacting proteins for UCN (P550893 ENSP000002960994) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
CRHR1P349983, ENSP000003813334I2D: score=4 STRING: ENSP00000381333
CRHBPP243873, ENSP000002743684I2D: score=2 STRING: ENSP00000274368
LEPP411593, ENSP000003126524I2D: score=1 STRING: ENSP00000312652
CRHR2Q133243I2D: score=3 
HDAC4ENSP000002646064STRING: ENSP00000264606
About this table

Gene Ontology (GO): Selected biological process terms (see all 45):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001934positive regulation of protein phosphorylation ----
GO:0006954inflammatory response IEA--
GO:0006979response to oxidative stress IEA--
GO:0007186G-protein coupled receptor signaling pathway TAS8612563
GO:0007218neuropeptide signaling pathway IEA--

UCN for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for UCN (UCN1)

Selected Novoseek inferred chemical compound relationships for UCN gene (see all 29)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
sauvagine 96.3 68 10375459 (3), 9415408 (3), 10777063 (3), 9326293 (2) (see all 38)
astressin 91.2 19 9449626 (5), 19703147 (2), 10199789 (2), 9886092 (1) (see all 12)
antalarmin 79 2 19703147 (1), 16174714 (1)
acth 57 25 10199789 (5), 9360550 (2), 9533639 (2), 10818395 (1) (see all 11)
cyclic amp 31 3 9628819 (1), 15206947 (1), 10336722 (1)
adenylate 30.7 6 12746280 (2), 12366528 (1), 17952632 (1), 12401516 (1)
forskolin 29.9 2 12810578 (1), 17170072 (1)
dehydroepiandrosterone sulfate 21.1 1 16014403 (1)
sodium cromoglycate 17.8 1 16614391 (1)
charybdotoxin 15.7 1 15721872 (1)



UCN for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for UCN gene: 
NM_003353.2  

Unigene Cluster for UCN:

Urocortin
Hs.534363  [show with all ESTs]
Unigene Representative Sequence: BU194700
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000296099(uc002rjp.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat UCN using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate UCN
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for UCN
Predesigned siRNA for gene silencing in human, mouse, rat UCN
Clone
Products:
     
OriGene clones in human, mouse for UCN (see all 5)
OriGene ORF clones in mouse, rat for UCN
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: UCN (NM_003353)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCN
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for UCN
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UCN
  QuantiTect SYBR Green Assays in human, mouse, rat UCN
  QuantiFast Probe-based Assays in human, mouse, rat UCN

Additional mRNA sequence: 

BC104470.1 BC104471.2 CR542244.1 

3 DOTS entries:

DT.97810288  DT.70102959  DT.40195367 

Selected AceView cDNA sequences (see all 39):

BM714994 CA430333 AI344591 CR542244 BU621095 AW139263 AI693759 AI690184 
BU619919 BF115396 AI631203 AI382328 BE043042 AI206260 CA432489 AI368662 
BE042927 NM_003353 AI093441 BE218419 AW015145 BE856859 R66755 AI857458 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

UCN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGGCAGGCGG
UCN Expression
About this image


UCN expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Neural Tube (Nervous System)
         Mesencephalon
 
 Bone (Muscoskeletal System)
UCN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

UCN Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.534363
    Pathway & Disease-focused RT2 Profiler PCR Arrays including UCN: 
          Neurotrophins & Receptors in human mouse rat
          Obesity in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for UCN
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UCN
QuantiTect SYBR Green Assays in human, mouse, rat UCN
QuantiFast Probe-based Assays in human, mouse, rat UCN
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCN

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for UCN gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ucn1 , 5 urocortin1, 5 84.31(n)1
84.87(a)1
  5 (17.11 cM)5
222261  NM_021290.21  NP_067265.11 
 311380635 
zebrafish
(Danio rerio)
Actinopterygii uts16
urotensin 1
30(a)
1 ↔ 1
20(38749284-38752105) ENSDARG00000014927


ENSEMBL Gene Tree for UCN (if available)
TreeFam Gene Tree for UCN (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for UCN (see all 26)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1870504451,2
--27452930(+) AGAACC/TCGAGC 1 -- ds50010--------
rs1424532501,2
--27452940(+) CGTCCC/GAGACC 1 -- ds50010--------
rs789547401,2
--27453087(+) AGGAGC/TGAACT 1 -- ds50010--------
rs1903366311,2
--27453290(+) CCCACA/GCTGCT 1 -- ds50010--------
rs1398052481,2
C--27453404(+) TCTGGG/TGTGGG 1 -- ut310--------
rs283640451,2
C,F,H--27453415(-) GACCCC/TTTTCC 1 -- ut31 ese3 trp36Minor allele frequency- T:0.02NS NA EU 2089
rs283640461,2
C--27531015(-) GCTCAG/AAGCGT 1 -- int11Minor allele frequency- A:0.01--86
rs1140699081,2
F--27531185(+) GAACAT/AGCACT 1 -- us2k11Minor allele frequency- A:0.08WA 118
rs1879058931,2
--27531416(+) CAGACC/TAGACT 1 -- us2k10--------
rs1393605311,2
--27531532(+) CGCTGG/TGCCGC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for UCN (27530265 - 27531313 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for UCN:    About this table    
Variant IDTypeSubtypePubMed ID
nsv873754CNV Loss21882294
nsv833614CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing UCN
DNA2.0 Custom Variant and Variant Library Synthesis for UCN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 600945    OMIM disorders: --

Selected diseases for UCN (see all 38):    
About MalaCards
thyroid medullary carcinoma    ischemic heart disease    systolic heart failure    endometrial carcinoma
panic disorder    anorexia nervosa    allergic asthma    endometriosis
pheochromocytoma    gastritis    nonsyndromic deafness    diabetes insipidus
sensorineural hearing loss    pituitary adenoma    multiple endocrine neoplasia    osteoarthritis
retinoblastoma    prostate adenocarcinoma    adenoma    asthma

3 diseases from the University of Copenhagen DISEASES database for UCN:
Nonsyndromic deafness     Sensorineural hearing loss     Kidney failure

UCN for disorders           About GeneDecksing

Selected Novoseek inferred disease relationships for UCN gene (see all 34)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
preterm delivery 22.3 7 19893766 (2), 19619932 (2), 17986644 (1), 16174714 (1)
heart failure 21.2 20 18180061 (3), 15320777 (2), 17506295 (2), 19808377 (2) (see all 10)
preeclampsia 21 9 15924674 (3), 16915033 (2), 18777033 (2), 17083971 (1)
inflammation 19.9 9 11352772 (2), 16427607 (1), 12746287 (1), 11337096 (1) (see all 7)
adrenal tumor 17.7 2 16095756 (1), 15914529 (1)
pheochromocytoma 13.1 2 18480660 (1), 15914529 (1)
ischemia 2.96 11 19660384 (3), 12234964 (1), 17516166 (1), 18180061 (1) (see all 7)
endometriosis 2.49 4 15494048 (3)
miscarriage 2.03 4 12746287 (2), 14602808 (1), 17083971 (1)
heart diseases 1.3 9 14577573 (4), 17258092 (1), 19307705 (1)

Genetic Association Database (GAD): UCN
Human Genome Epidemiology (HuGE) Navigator: UCN (5 documents)

Export disorders for UCN gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for UCN gene, integrated from 10 sources (see all 281):
(articles sorted by number of sources associating them with UCN)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The structures of the mouse and human urocortin genes (Ucn and UCN). (PubMed id 9628819)1, 2, 3, 9 Zhao L.... Vale W.W. (Genomics 1998)
  2. Cloning and characterization of human urocortin. (PubMed id 8612563)1, 2, 9 Donaldson C.J.... Vale W.W. (Endocrinology 1996)
  3. Mutation screening of the urocortin gene: identification of new single nucleotide polymorphisms and association studies with obesity in French Caucasians. (PubMed id 11836334)1, 4, 9 Delplanque J....Froguel P. (J. Clin. Endocrinol. Metab. 2002)
  4. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
  6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. [Dynamics of matrix synthesis in molecular biophysics. II. Principle of insertability and the single-valued solution of feedback tasks]. (PubMed id 861256)1, 3 Tsarev O.B. (Biofizika 1977)
  9. Urocortin has cell-proliferative effects on cardiac non-myocytes. (PubMed id 12175707)1, 9 Ikeda K....Nakao K. (Life Sci. 2002)
  10. Expression of urocortin in the extravillous human trophoblast at the implantation site. (PubMed id 16698078)1, 9 Bamberger C.M....Makrigiannakis A. (Placenta 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 7349 HGNC: 12516 AceView: UCN Ensembl:ENSG00000163794 euGenes: HUgn7349
ECgene: UCN H-InvDB: UCN

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for UCN Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for UCN gene:
Search GeneIP for patents involving UCN

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Antibodies for UCN (Urocortin)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for UCN   OriGene RNAi products in human, mouse, rat for UCN  
 Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for UCN  
 OriGene qSTAR qPCR primer pairs in human, mouse for UCN   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for UCN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for UCN   OriGene Custom Protein Services for UCN  

 
 
 Block miRNA regulation of human, mouse, rat UCN using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UCN
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UCN Predesigned siRNA for gene silencing in human, mouse, rat UCN
 QuantiFast Probe-based Assays in human, mouse, rat UCN QuantiTect SYBR Green Assays in human, mouse, rat UCN
 PCR Arrays including human, mouse, rat UCN Search Chromatin IP Primers for UCN
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UCN  GeneGlobe Interaction Network for UCN
 Regulatory tfbs in UCN promoter
 GenScript Custom Purified and Recombinant Proteins Services for UCN GenScript cDNA clones with any tag delivered in your preferred vector for UCN
 GenScript Custom Assay Services for UCN GenScript Custom overexpressing Cell Line Services for UCN
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for UCN (UCN1)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 UCN antibodies
 Antibodies for UCN
 See all of Abcam's Antibodies, Kits and Proteins for UCN
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for UCN
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCN
 Browse SwitchGear 3'UTR luciferase reporter plasmids for UCN
 SwitchGear Promoter luciferase reporter plasmids for UCN
 ThermoFisher Antibodies for UCN
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCN
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UCN
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UCN
 LSBio Antibodies in human, mouse, rat for UCN
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      UCN gene at Home site.
Version: 3.12.142 28 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4