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Aliases for UCN Gene

Aliases for UCN Gene

  • Urocortin 2 3 5
  • Prepro-Urocortin 2 3
  • Urocortin, Preproprotein 3
  • UROC 3
  • UI 3

External Ids for UCN Gene

Previous GeneCards Identifiers for UCN Gene

  • GC02M027451
  • GC02M027622
  • GC02M027504
  • GC02M027441
  • GC02M027383
  • GC02M027530

Summaries for UCN Gene

Entrez Gene Summary for UCN Gene

  • This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]

GeneCards Summary for UCN Gene

UCN (Urocortin) is a Protein Coding gene. Diseases associated with UCN include Auditory System Disease and Obesity. Among its related pathways are Activation of cAMP-Dependent PKA and G-Beta Gamma Signaling. GO annotations related to this gene include hormone activity and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for UCN Gene

  • Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).

Gene Wiki entry for UCN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCN Gene

Genomics for UCN Gene

Regulatory Elements for UCN Gene

Enhancers for UCN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UCN on UCSC Golden Path with GeneCards custom track

Genomic Location for UCN Gene

Chromosome:
2
Start:
27,307,397 bp from pter
End:
27,308,445 bp from pter
Size:
1,049 bases
Orientation:
Minus strand

Genomic View for UCN Gene

Genes around UCN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCN Gene

Proteins for UCN Gene

  • Protein details for UCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55089-UCN1_HUMAN
    Recommended name:
    Urocortin
    Protein Accession:
    P55089
    Secondary Accessions:
    • Q6FG64

    Protein attributes for UCN Gene

    Size:
    124 amino acids
    Molecular mass:
    13458 Da
    Quaternary structure:
    • Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).
    Miscellaneous:
    • Positive correlation between increased expression in colonic lamina propria and severity of inflammation in patients with ulcerative colitis.

    Three dimensional structures from OCA and Proteopedia for UCN Gene

neXtProt entry for UCN Gene

Proteomics data for UCN Gene at MOPED

Post-translational modifications for UCN Gene

No Post-translational modifications

Other Protein References for UCN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for UCN Gene

Domains & Families for UCN Gene

Gene Families for UCN Gene

Protein Domains for UCN Gene

Suggested Antigen Peptide Sequences for UCN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55089

UniProtKB/Swiss-Prot:

UCN1_HUMAN :
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Family:
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
genes like me logo Genes that share domains with UCN: view

Function for UCN Gene

Molecular function for UCN Gene

GENATLAS Biochemistry:
urocortin,corticotropin releasing factor family,containing in its 5utr region the MPV17 gene
UniProtKB/Swiss-Prot Function:
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).

Gene Ontology (GO) - Molecular Function for UCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046811 histone deacetylase inhibitor activity IEA --
genes like me logo Genes that share ontologies with UCN: view
genes like me logo Genes that share phenotypes with UCN: view

Animal Models for UCN Gene

MGI Knock Outs for UCN:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for UCN Gene

Localization for UCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCN Gene COMPARTMENTS Subcellular localization image for UCN gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for UCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with UCN: view

Pathways & Interactions for UCN Gene

genes like me logo Genes that share pathways with UCN: view

Pathways by source for UCN Gene

Gene Ontology (GO) - Biological Process for UCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0001964 startle response IEA --
GO:0006979 response to oxidative stress IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8612563
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with UCN: view

No data available for SIGNOR curated interactions for UCN Gene

Drugs & Compounds for UCN Gene

(21) Drugs for UCN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for UCN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UCN: view

Transcripts for UCN Gene

mRNA/cDNA for UCN Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(39) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UCN Gene

Urocortin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCN Gene

No ASD Table

Relevant External Links for UCN Gene

GeneLoc Exon Structure for
UCN
ECgene alternative splicing isoforms for
UCN

Expression for UCN Gene

mRNA expression in normal human tissues for UCN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UCN Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UCN Gene



SOURCE GeneReport for Unigene cluster for UCN Gene Hs.534363

mRNA Expression by UniProt/SwissProt for UCN Gene

P55089-UCN1_HUMAN
Tissue specificity: Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481).
genes like me logo Genes that share expression patterns with UCN: view

Protein tissue co-expression partners for UCN Gene

Primer Products

No data available for mRNA differential expression in normal tissues for UCN Gene

Orthologs for UCN Gene

This gene was present in the common ancestor of chordates.

Orthologs for UCN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UCN 35
  • 90.05 (n)
  • 87.9 (a)
UCN 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCN 35
  • 88.71 (n)
  • 87.9 (a)
UCN 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ucn 35
  • 84.31 (n)
  • 84.87 (a)
Ucn 16
Ucn 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UCN 35
  • 98.12 (n)
  • 97.58 (a)
UCN 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ucn 35
  • 83.47 (n)
  • 84.87 (a)
oppossum
(Monodelphis domestica)
Mammalia UCN 36
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii uts1 36
  • 30 (a)
OneToOne
Species with no ortholog for UCN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UCN Gene

ENSEMBL:
Gene Tree for UCN (if available)
TreeFam:
Gene Tree for UCN (if available)

Paralogs for UCN Gene

No data available for Paralogs for UCN Gene

Variants for UCN Gene

Sequence variations from dbSNP and Humsavar for UCN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6709781 -- 27,307,997(+) CCCCT(C/G)CGGCC intron-variant
rs6731600 -- 27,308,797(+) CAGCA(C/T)TCTTA upstream-variant-2KB
rs11557508 -- 27,308,420(+) GGGGC(C/T)AGCGC upstream-variant-2KB
rs35403114 -- 27,308,101(+) GGTGG(C/T)TGAGC intron-variant
rs28364046 -- 27,308,147(-) GCTCA(A/G)AGCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UCN Gene

Variant ID Type Subtype PubMed ID
nsv873754 CNV Loss 21882294
nsv833614 CNV Gain 17160897

Variation tolerance for UCN Gene

Gene Damage Index Score: 0.62; 13.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UCN Gene

Disorders for UCN Gene

MalaCards: The human disease database

(3) MalaCards diseases for UCN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
auditory system disease
  • destruction - ear drum
obesity
  • obesity, association with
inner ear disease
  • disease of inner ear
- elite association - COSMIC cancer census association via MalaCards
Search UCN in MalaCards View complete list of genes associated with diseases

Relevant External Links for UCN

Genetic Association Database (GAD)
UCN
Human Genome Epidemiology (HuGE) Navigator
UCN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UCN
genes like me logo Genes that share disorders with UCN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UCN Gene

Publications for UCN Gene

  1. The structures of the mouse and human urocortin genes (Ucn and UCN). (PMID: 9628819) Zhao L. … Vale W.W. (Genomics 1998) 2 3 4 23 67
  2. Circulating levels of stress associated peptide Urocortin in heart failure patients. (PMID: 19961889) Gruson D. … Rousseau M.F. (Peptides 2010) 3 23
  3. Amniotic fluid urocortin, CRF, oestriol, dehydroepiandrosterone sulfate and cortisol concentrations at mid-trimester: putative relationship with preterm delivery. (PMID: 19619932) Torricelli M. … Petraglia F. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2009) 3 23
  4. Urocortin increases IL-4 and IL-10 secretion and reverses LPS-induced TNF-alpha release from human trophoblast primary cells. (PMID: 19703147) Torricelli M. … Petraglia F. (Am. J. Reprod. Immunol. 2009) 3 23
  5. Urocortin in second trimester amniotic fluid: its role as predictor of preterm labor. (PMID: 19893766) Iavazzo C. … Malamitsi-Puchner A. (Mediators Inflamm. 2009) 3 23

Products for UCN Gene

Sources for UCN Gene

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