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Aliases for UCMA Gene

Aliases for UCMA Gene

  • Upper Zone Of Growth Plate And Cartilage Matrix Associated 2 3 5
  • C10orf49 3 4
  • Chromosome 10 Open Reading Frame 49 2
  • Gla-Rich Protein 3
  • GRP/UCMA 3
  • GRP 3

External Ids for UCMA Gene

Previous HGNC Symbols for UCMA Gene

  • C10orf49

Previous GeneCards Identifiers for UCMA Gene

  • GC10M013304
  • GC10M013176
  • GC10M013263

Summaries for UCMA Gene

Entrez Gene Summary for UCMA Gene

  • This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

GeneCards Summary for UCMA Gene

UCMA (Upper Zone Of Growth Plate And Cartilage Matrix Associated) is a Protein Coding gene. GO annotations related to this gene include selenium binding.

UniProtKB/Swiss-Prot for UCMA Gene

  • May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCMA Gene

Genomics for UCMA Gene

Regulatory Elements for UCMA Gene

Enhancers for UCMA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UCMA on UCSC Golden Path with GeneCards custom track

Genomic Location for UCMA Gene

13,221,766 bp from pter
13,234,334 bp from pter
12,569 bases
Minus strand

Genomic View for UCMA Gene

Genes around UCMA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCMA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCMA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCMA Gene

Proteins for UCMA Gene

  • Protein details for UCMA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Unique cartilage matrix-associated protein
    Protein Accession:

    Protein attributes for UCMA Gene

    138 amino acids
    Molecular mass:
    16563 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UCMA Gene

Proteomics data for UCMA Gene at MOPED

Post-translational modifications for UCMA Gene

  • Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the entire cartilage matrix, and affecting osteoblast differentiation.
  • Sulfated on tyrosine residues.

Other Protein References for UCMA Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for UCMA

No data available for DME Specific Peptides for UCMA Gene

Domains & Families for UCMA Gene

Protein Domains for UCMA Gene


Suggested Antigen Peptide Sequences for UCMA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UCMA family.
  • Belongs to the UCMA family.
genes like me logo Genes that share domains with UCMA: view

No data available for Gene Families for UCMA Gene

Function for UCMA Gene

Molecular function for UCMA Gene

UniProtKB/Swiss-Prot Function:
May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.

Phenotypes for UCMA Gene

MGI mutant phenotypes for UCMA:
inferred from 1 alleles
GenomeRNAi human phenotypes for UCMA:
genes like me logo Genes that share phenotypes with UCMA: view

Animal Models for UCMA Gene

MGI Knock Outs for UCMA:

Animal Model Products

  • Taconic Biosciences Mouse Models for UCMA

CRISPR Products

miRNA for UCMA Gene

miRTarBase miRNAs that target UCMA

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UCMA Gene

Localization for UCMA Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCMA Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for UCMA Gene COMPARTMENTS Subcellular localization image for UCMA gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for UCMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016235 aggresome IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with UCMA: view

Pathways & Interactions for UCMA Gene

SuperPathways for UCMA Gene

No Data Available

Interacting Proteins for UCMA Gene

Gene Ontology (GO) - Biological Process for UCMA Gene


No data available for Pathways by source and SIGNOR curated interactions for UCMA Gene

Drugs & Compounds for UCMA Gene

No Compound Related Data Available

Transcripts for UCMA Gene

mRNA/cDNA for UCMA Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UCMA Gene

Upper zone of growth plate and cartilage matrix associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCMA Gene

No ASD Table

Relevant External Links for UCMA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UCMA Gene

mRNA expression in normal human tissues for UCMA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UCMA Gene

This gene is overexpressed in Brain - Amygdala (x26.7) and Pituitary (x9.7).

SOURCE GeneReport for Unigene cluster for UCMA Gene Hs.112998

mRNA Expression by UniProt/SwissProt for UCMA Gene

Tissue specificity: Predominantly expressed in resting chondrocytes.
genes like me logo Genes that share expression patterns with UCMA: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for UCMA Gene

Orthologs for UCMA Gene

This gene was present in the common ancestor of chordates.

Orthologs for UCMA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UCMA 35
  • 81.86 (n)
  • 77.94 (a)
(Canis familiaris)
Mammalia UCMA 35
  • 82.24 (n)
  • 80.29 (a)
  • 80 (a)
(Mus musculus)
Mammalia Ucma 35
  • 82.61 (n)
  • 78.99 (a)
Ucma 16
Ucma 36
  • 79 (a)
(Pan troglodytes)
Mammalia UCMA 35
  • 98.79 (n)
  • 97.1 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Ucma 35
  • 78.53 (n)
  • 78.81 (a)
(Monodelphis domestica)
Mammalia UCMA 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia UCMA 36
  • 69 (a)
(Anolis carolinensis)
Reptilia UCMA 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15650 35
ucma 35
  • 63.29 (n)
  • 62.32 (a)
(Danio rerio)
Actinopterygii ucmab 35
  • 60.15 (n)
  • 51.88 (a)
ucmab 36
  • 50 (a)
Species with no ortholog for UCMA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UCMA Gene

Gene Tree for UCMA (if available)
Gene Tree for UCMA (if available)

Paralogs for UCMA Gene

No data available for Paralogs for UCMA Gene

Variants for UCMA Gene

Sequence variations from dbSNP and Humsavar for UCMA Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1535851 -- 13,224,664(+) GTGGC(A/G)ATGGC intron-variant
rs1535855 -- 13,233,056(+) GTCCC(C/T)AGACC intron-variant
rs3030194 -- 13,232,395(+) AAAAA(-/AG)AGGAC intron-variant
rs3829925 -- 13,233,553(+) ATCTC(A/G/T)GGACT intron-variant, reference, synonymous-codon
rs3829926 -- 13,233,676(+) GGTGC(C/T)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UCMA Gene

Variant ID Type Subtype PubMed ID
nsv528026 CNV Loss 19592680
nsv521216 CNV Loss 19592680

Variation tolerance for UCMA Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UCMA Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCMA Gene

Disorders for UCMA Gene

Relevant External Links for UCMA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UCMA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UCMA Gene

Publications for UCMA Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Insights into the association of Gla-rich protein and osteoarthritis, novel splice variants and I^-carboxylation status. (PMID: 24867294) Rafael M.S. … Simes D.C. (Mol Nutr Food Res 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Exon resequencing of the gene encoding UCma/GRP reveals a common carboxy-terminal 138Thr > Ser polymorphism. (PMID: 24409676) Osman A. … Magnusson P. (Clin. Lab. 2013) 3

Products for UCMA Gene

Sources for UCMA Gene