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Aliases for UCMA Gene

Aliases for UCMA Gene

  • Upper Zone Of Growth Plate And Cartilage Matrix Associated 2 3
  • C10orf49 3 4
  • Unique Cartilage Matrix-Associated Protein 3
  • Chromosome 10 Open Reading Frame 49 2
  • Gla-Rich Protein 3
  • GRP/UCMA 3
  • GRP 3

External Ids for UCMA Gene

Previous Symbols for UCMA Gene

  • C10orf49

Summaries for UCMA Gene

GeneCards Summary for UCMA Gene

UCMA (Upper Zone Of Growth Plate And Cartilage Matrix Associated) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR.

UniProtKB/Swiss-Prot for UCMA Gene

  • May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCMA Gene

Genomics for UCMA Gene

Genomic Location for UCMA Gene

13,221,767 bp from pter
13,234,334 bp from pter
12,568 bases
Minus strand

Genomic View for UCMA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UCMA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCMA Gene

Regulatory Elements for UCMA Gene

Proteins for UCMA Gene

  • Protein details for UCMA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Unique cartilage matrix-associated protein
    Protein Accession:
    Secondary Accessions:

    Protein attributes for UCMA Gene

    138 amino acids
    Molecular mass:
    16563 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UCMA Gene

Proteomics data for UCMA Gene at MOPED

Post-translational modifications for UCMA Gene

  • Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the entire cartilage matrix, and affecting osteoblast differentiation.
  • Sulfated on tyrosine residues.

Other Protein References for UCMA Gene

No data available for DME Specific Peptides for UCMA Gene

Domains for UCMA Gene

Protein Domains for UCMA Gene



  • Belongs to the UCMA family.:
    • Q8WVF2
genes like me logo Genes that share domains with UCMA: view

No data available for Gene Families for UCMA Gene

Function for UCMA Gene

Molecular function for UCMA Gene

UniProtKB/Swiss-Prot Function: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.

Gene Ontology (GO) - Molecular Function for UCMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008430 selenium binding --
genes like me logo Genes that share ontologies with UCMA: view

Phenotypes for UCMA Gene

MGI mutant phenotypes for UCMA:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with UCMA: view

miRNA for UCMA Gene

miRTarBase miRNAs that target UCMA

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UCMA Gene

Localization for UCMA Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCMA Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for UCMA Gene COMPARTMENTS Subcellular localization image for UCMA gene
Compartment Confidence
extracellular 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for UCMA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA --
GO:0016235 aggresome IEA --
GO:0030176 integral component of endoplasmic reticulum membrane --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with UCMA: view

Transcripts for UCMA Gene

mRNA/cDNA for UCMA Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UCMA Gene

Upper zone of growth plate and cartilage matrix associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCMA Gene

No ASD Table

Relevant External Links for UCMA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UCMA Gene

mRNA expression in normal human tissues for UCMA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UCMA Gene

This gene is overexpressed in Brain - Amygdala (26.7) and Pituitary (9.7).

SOURCE GeneReport for Unigene cluster for UCMA Gene Hs.112998

mRNA Expression by UniProt/SwissProt for UCMA Gene

Tissue specificity: Predominantly expressed in resting chondrocytes.
genes like me logo Genes that share expressions with UCMA: view

Orthologs for UCMA Gene

This gene was present in the common ancestor of chordates.

Orthologs for UCMA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UCMA 36
  • 98.79 (n)
  • 97.1 (a)
  • 97 (a)
(Bos Taurus)
Mammalia UCMA 36
  • 81.86 (n)
  • 77.94 (a)
(Canis familiaris)
Mammalia UCMA 36
  • 82.24 (n)
  • 80.29 (a)
  • 80 (a)
(Mus musculus)
Mammalia Ucma 36
  • 82.61 (n)
  • 78.99 (a)
Ucma 16
Ucma 37
  • 79 (a)
(Monodelphis domestica)
Mammalia UCMA 37
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia UCMA 37
  • 69 (a)
(Rattus norvegicus)
Mammalia Ucma 36
  • 78.53 (n)
  • 78.81 (a)
(Anolis carolinensis)
Reptilia UCMA 37
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15650 36
ucma 36
  • 63.29 (n)
  • 62.32 (a)
(Danio rerio)
Actinopterygii ucmab 36
  • 60.15 (n)
  • 51.88 (a)
ucmab 37
  • 50 (a)
Species with no ortholog for UCMA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UCMA Gene

Gene Tree for UCMA (if available)
Gene Tree for UCMA (if available)

Paralogs for UCMA Gene

No data available for Paralogs for UCMA Gene

Variants for UCMA Gene

Sequence variations from dbSNP and Humsavar for UCMA Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs942413 -- 13,224,987(+) CAAGC(C/T)CAGTA intron-variant
rs942414 -- 13,225,117(+) TGCAG(C/T)GGCAC intron-variant
rs942415 -- 13,225,208(+) ACCAC(C/G)ATGCC intron-variant
rs942416 -- 13,227,931(+) CAGCC(A/G)CACCA intron-variant
rs942417 -- 13,228,039(+) ACTGG(A/G)CTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UCMA Gene

Variant ID Type Subtype PubMed ID
nsv528026 CNV Loss 19592680
nsv521216 CNV Loss 19592680

Relevant External Links for UCMA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for UCMA Gene

No disorders were found for UCMA Gene.

No data available for UniProtKB/Swiss-Prot for UCMA Gene

Publications for UCMA Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Ucma--A novel secreted factor represents a highly specific marker for distal chondrocytes. (PMID: 17707622) Tagariello A. … Winterpacht A. (Matrix Biol. 2008) 3
  5. Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis. (PMID: 18156182) Surmann-Schmitt C. … Stock M. (J. Biol. Chem. 2008) 3

Products for UCMA Gene

Sources for UCMA Gene

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