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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UCMA Gene

protein-coding   GIFtS: 40
GCID: GC10M013263

upper zone of growth plate and cartilage matrix associated

(Previous name: chromosome 10 open reading frame 49 )
(Previous symbol: C10orf49)
 Explore 1 disease affiliated with
UCMA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UCMA    

Aliases
for UCMA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Upper Zone Of Growth Plate And Cartilage Matrix Associated1 2
C10orf491 2 3
Chromosome 10 Open Reading Frame 491
GRP2
Gla-Rich Protein2
Unique Cartilage Matrix-Associated Protein2

External Ids:    HGNC: 252051   Entrez Gene: 2210442   Ensembl: ENSG000001656237   UniProtKB: Q8WVF23   

Export aliases for UCMA gene to outside databases

Previous GC identifers: GC10M013304 GC10M013176


Summaries
for UCMA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: UCMA_HUMAN, Q8WVF2
Function: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in
peripheral zones of fetal cartilage and at the cartilage-bone interface (By similarity)

summary for UCMA:
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B
(NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor
(BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). The
receptors are Gq/11-coupled and are involved in the regulation of many biological functions including
sensory transmission, thermoregulation, feeding and pituitary, gastric and pancreatic secretion. They may
also be involved in tissue development, proliferation and differentiation.




Genomic Views
for UCMA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UCMA gene promoter:
         NRSF form 1   FOXD1   NRSF form 2   NF-AT   NF-AT4   NF-AT2   POU2F1a   NF-AT3   Pax-4a   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UCMA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCMA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

UCMA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCMA gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M013263:  view genomic region     (about GC identifiers)

Start:
 13,263,767 bp from pter      End:
 13,276,331 bp from pter
Size:
 12,565 bases      Orientation:
 minus strand

Proteins
for UCMA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UCMA_HUMAN, Q8WVF2 (See protein sequence)
Recommended Name: Unique cartilage matrix-associated protein precursor  
Size: 138 amino acids; 16563 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Explore the universe of human proteins at neXtProt for UCMA: NX_Q8WVF2

Post-translational modifications:

  • Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the
    • entire cartilage matrix, and affecting osteoblast differentiation (By similarity)1
  • Sulfated on tyrosine residues (By similarity)1
  • View neXtProt modification sites for NX_Q8WVF2

    • UCMA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_660357.2  
    ENSEMBL proteins: 
     ENSP00000367952  

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    Uscn Proteins for UCMA

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IEA--
    GO:0016235aggresome IEA--
    GO:0031012extracellular matrix ----
    GO:0048471perinuclear region of cytoplasm IEA--


    UCMA for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for UCMA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8WVF2

    UniProtKB/Swiss-Prot: UCMA_HUMAN, Q8WVF2
    Similarity: Belongs to the UCMA family


    Function
    for UCMA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UCMA_HUMAN, Q8WVF2
    Function: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in
    peripheral zones of fetal cartilage and at the cartilage-bone interface (By similarity)

    miRNA
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    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ucma):
     skeleton 

    UCMA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for UCMA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UCMA

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045668negative regulation of osteoblast differentiation IEA--


    UCMA for ontologies           About GeneDecksing



    Drugs & Compounds
    for UCMA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for UCMA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BombesinInvolved in gastrointestinal tract function[31362-50-2]
    PD 176252GRP (BB2) and NMB (BB1) receptor antagonist[204067-01-6]
    BIM 187Bombesin/GRP receptor agonist[137734-88-4]
    GRP (human)Endogenous GRP receptor agonist[93755-85-2]
    BIM 189Bombesin antagonist[142062-55-3]
    Search CenterWatch for drugs/clinical trials and news about UCMA 

    Transcripts
    for UCMA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for UCMA gene: 
    NM_145314.1  

    Unigene Cluster for UCMA:

    Upper zone of growth plate and cartilage matrix associated
    Hs.112998  [show with all ESTs]
    Unigene Representative Sequence: BG709040
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378681(uc001imd.3) ENST00000463405

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate UCMA:
    hsa-miR-1178
    SwitchGear 3'UTR luciferase reporter plasmid: UCMA 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: BC018068.1 

    1 DOTS entry:

    DT.100008722 

    17 AceView cDNA sequences:

    AI123014 BI492502 BF111669 BG709040 AA993036 AI275700 BC018068 BX096251 
    AA628504 NM_145314 AI808049 BG187136 AA621553 BI492556 AI761841 AW021545 
    BG714828 

    GeneLoc Exon Structure


    Expression
    for UCMA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UCMA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTTTCCTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UCMA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular NodeAtrioventricular Node CellsMyocardium
    BoneZeugopod Epiphyseal EndBone
    BoneZeugopod Growth PlateBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UCMA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UCMA

    SOURCE GeneReport for Unigene cluster: Hs.112998

    UniProtKB/Swiss-Prot: UCMA_HUMAN, Q8WVF2
    Tissue specificity: Predominantly expressed in resting chondrocytes

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    In Situ
    Assay Products:     
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    Orthologs
    for UCMA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for UCMA gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ucma1 , 5 upper zone of growth plate and cartilage matrix associated1, 5 82.97(n)1
    79.56(a)1    		   2 (3.11 cM)5
    685271  NM_001113558.21  NP_001107030.11 
     49761255 
    lizard
    (Anolis carolinensis)    		 Reptilia UCMA6
    		 --
    		 60(a)
    		 1 ↔ 1
    		 5(89958488-89968915)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.156502 Transcribed sequences 74.83(n)    142025081 
    zebrafish
    (Danio rerio)    		 Actinopterygii ucmab1 upper zone of growth plate and cartilage matrix associated more 59.9(n)
    51.88(a)    		   405870  NM_212934.1  NP_998099.1 


    ENSEMBL Gene Tree for UCMA (if available)
    TreeFam Gene Tree for UCMA (if available) 

    Paralogs
    for UCMA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for UCMA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    6 NCBI SNPs in UCMA are shown     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs558450781,2
    		C--13273089(+) TCCTTCTT/-GGAAG 1 -- int11Minor allele frequency- -:0.00NA 2
    rs30301941,2
    		C,--13274395(+) aaaaG-/AGGACAG 1 -- int1 trp30--------
    rs713861691,2
    		----13263469(-) ACTTT-/TTTTTTTT 1 -- int11Minor allele frequency- TTT:0.00NA 2
    rs558312411,2
    		----13269780(+) ACACA-/CATTCTC 1 -- int10--------
    rs713861701,2
    		----13263514(-) TGTGTGT/-ATATA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs577164211,2
    		----13263469(+) AAAAA-/AAAGTGTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for UCMA (13263767 - 13276331 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for UCMA: --
    Human Gene Mutation Database (HGMD): UCMA

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    Disorders / Diseases
    for UCMA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UCMA for disorders           About GeneDecksing

    1 disease for UCMA:    About MalaCards
    pancreatitis


    Export disorders for UCMA gene to outside databases

    Publications
    for UCMA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UCMA gene integrated from 9 sources:
    (articles sorted by number of sources associating them with UCMA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis. (PubMed id 18156182)1 Surmann-Schmitt C....Stock M. (2008)
    5. Ucma--A novel secreted factor represents a highly specific marker for distal chondrocytes. (PubMed id 17707622)1 Tagariello A....Winterpacht A. (2008)
    6. Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. (PubMed id 18836183)1 Viegas C.S....Cancela M.L. (2008)
    7. Expression profiling of human fetal growth plate cartilage by EST sequencing. (PubMed id 16176871)2 Tagariello A....Zabel B. (2005)

    External Searches for UCMA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UCMA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221044 HGNC: 25205 AceView: C10orf49 Ensembl:ENSG00000165623 euGenes: HUgn221044
    ECgene: UCMA H-InvDB: UCMA

    Other Databases showing UCMA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UCMA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UCMA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UCMA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UCMA gene:
    Search GeneIP for patents involving UCMA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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