Aliases for UCMA Gene
External Ids for UCMA Gene
Previous HGNC Symbols for UCMA Gene
Previous GeneCards Identifiers for UCMA Gene
This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
GeneCards Summary for UCMA Gene
UCMA (Upper Zone Of Growth Plate And Cartilage Matrix Associated) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include selenium binding.
UniProtKB/Swiss-Prot for UCMA Gene
May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.