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UCKL1 Gene

protein-coding   GIFtS: 59
GCID: GC20M062571

Uridine-Cytidine Kinase 1-Like 1

(Previous name: uridine kinase-like 1)
(Previous symbol: URKL1)
  Search for UCKL1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Uridine-Cytidine Kinase 1-Like 11 2     UCK1L2 5
URKL11 2 3 5     UCK1-LIKE2
Uridine Kinase-Like 11 2     Uridine-Cytidine Kinase-Like 12
EC 2.7.1.483 8     

External Ids:    HGNC: 159381   Entrez Gene: 549632   Ensembl: ENSG000001982767   OMIM: 6108665   UniProtKB: Q9NWZ53   

Export aliases for UCKL1 gene to outside databases

Previous GC identifers: GC20M062041 GC20M059304


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UCKL1 Gene:
UCKL1 (uridine-cytidine kinase 1-like 1) is a protein-coding gene. GO annotations related to this gene include uridine kinase activity and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is UCK2.

UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5
Function: May contribute to UTP accumulation needed for blast transformation and proliferation

Gene Wiki entry for UCKL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UCKL1 gene promoter:
         AhR   Lmo2   LUN-1   AP-4   CUTL1   Arnt   FOXL1   HOXA5   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCKL1 promoter sequence
   Search Chromatin IP Primers for UCKL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UCKL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

UCKL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCKL1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M062571:  view genomic region     (about GC identifiers)

Start:
62,571,182 bp from pter      End:
62,587,800 bp from pter
Size:
16,619 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5 (See protein sequence)
Recommended Name: Uridine-cytidine kinase-like 1  
Size: 548 amino acids; 61141 Da
Subunit: Interacts with RNF19B and EBV EBNA3
Secondary accessions: B7Z8N2 Q5JWV0 Q70AQ5 Q8N524 Q9H3Z2
Alternative splicing: 4 isoforms:  Q9NWZ5-1   Q9NWZ5-2   Q9NWZ5-3   Q9NWZ5-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UCKL1: NX_Q9NWZ5

Explore proteomics data for UCKL1 at MOPED

Post-translational modifications: 

  • Ubiquitinated by RNF19B; which induces proteasomal degradation1
  • Ubiquitination2 at Lys111, Lys387, Lys392
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for UCKL1 (Q9NWZ5)
     DHPDAFD  NTVAIDL 


    See UCKL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180308.1  NP_060329.2  

    ENSEMBL proteins: 
     ENSP00000346155   ENSP00000358924   ENSP00000402994   ENSP00000358908   ENSP00000351546  

    UCKL1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for UCKL1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000764 Uridine_kinase
     IPR027417 P-loop_NTPase
     IPR006083 PRK/URK

    Graphical View of Domain Structure for InterPro Entry Q9NWZ5

    ProtoNet protein and cluster: Q9NWZ5

    1 Blocks protein domain: IPB000764 Uridine kinase signature

    UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5
    Similarity: Belongs to the uridine kinase family


    Find genes that share domains with UCKL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UCKL1_HUMAN, Q9NWZ5
    Function: May contribute to UTP accumulation needed for blast transformation and proliferation
    Catalytic activity: ATP + uridine = ADP + UMP
    Catalytic activity: ATP + cytidine = ADP + CMP

         Enzyme Number (IUBMB): EC 2.7.1.481 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004849uridine kinase activity IEA--
    GO:0005515protein binding IPI16709802
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0016740transferase activity ----
         
    Find genes that share ontologies with UCKL1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for UCKL1:
     G0/1 arrest  Increased G1 DNA content  Increased cell death HMECs cel 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UCKL1_HUMAN, Q9NWZ5: Cytoplasm. Nucleus. Note=EBNA3 induces isoform 1 translocation to the nucleus, whereas it
    does change isoform 3 location
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    endoplasmic reticulum4
    cytosol3
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005783endoplasmic reticulum ----

    Find genes that share ontologies with UCKL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UCKL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    Pyrimidine metabolism0.38
    2Metabolism
    Metabolic pathways0.38
    3Glucuronidation
    Drug metabolism - other enzymes0.36


    Find genes that share SuperPaths with UCKL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Kegg Pathways  (Kegg details for UCKL1):
        Pyrimidine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways

    UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5
    Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
    Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UCKL1
    Interactions:

        Search GeneGlobe Interaction Network for UCKL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UCKL1 (Q9NWZ51, 3 ENSP000003461554) via UniProtKB, MINT, STRING, and/or I2D (see all 70)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF19BQ6ZMZ01, 3, ENSP000003625554EBI-2466660,EBI-2466594 I2D: score=1 STRING: ENSP00000362555
    MAPRE1Q156913, ENSP000003647214I2D: score=1 STRING: ENSP00000364721
    EIF2B2P497703I2D: score=2 
    GPT2Q8TD303I2D: score=1 
    HSP90AA1P079003I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0044206UMP salvage IEA--
    GO:0044211CTP salvage IEA--

    Find genes that share ontologies with UCKL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UCKL1

    Selected HMDB Compounds for UCKL1 (see all 22)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cytidine1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)65-46-3--
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Deoxycytidine1-(2-Deoxy-b-D-ribofuranosyl)cytosine (see all 15)951-77-9--
    Deoxyuridine1-(2-Deoxy-D-erythro-pentofuranosyl)uracil (see all 12)951-78-0--
    Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--

    4 DrugBank Compounds for UCKL1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-Phosphoribosylpyrophosphoric Acid-- 13270-65-0target--17139284 17016423 10592235
    Guanosine-5'-Triphosphate-- 86-01-1target--17139284 17016423 10592235
    Uracil-- 66-22-8target--17139284 17016423 10592235
    Uridine-5'-Monophosphate-- 58-97-9target--17139284 17016423 10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UCKL1 gene (2 alternative transcripts): 
    NM_001193379.1  NM_017859.3  

    Unigene Cluster for UCKL1:

    Uridine-cytidine kinase 1-like 1
    Hs.504998  [show with all ESTs]
    Unigene Representative Sequence: AK128082
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354216(uc010gkn.3 uc011abn.2 uc011abo.2) ENST00000369908(uc011abm.2)
    ENST00000430743 ENST00000492660 ENST00000483710 ENST00000369892 ENST00000358711

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    hsa-miR-3163 hsa-miR-9*
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      QuantiFast Probe-based Assays in human, mouse, rat UCKL1

    Additional mRNA sequence: 

    AJ605558.1 AK000524.1 AK128082.1 AK222559.1 AK223220.1 AK301602.1 AK303688.1 BC033078.1 

    22 DOTS entries:

    DT.97817341  DT.95204026  DT.211623  DT.120803977  DT.75102038  DT.95173576  DT.95114287  DT.75109769 
    DT.209710  DT.120803978  DT.120803982  DT.100709734  DT.95173580  DT.100811435  DT.75118267  DT.100786530 
    DT.65287100  DT.95140900  DT.209709  DT.95256609  DT.120804018  DT.91741721 

    Selected AceView cDNA sequences (see all 172):

    AI478287 AW328301 BE501787 AI738474 AI744038 CB163966 BM926874 AI654629 
    BM702108 BM668439 BQ924776 BM758850 BQ637053 BM021921 AW236555 BQ640057 
    BF001641 AA020997 AI979128 CF127698 BM127708 AA516005 BU684988 BM693202 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UCKL1 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ·
    SP1:                    -     -                                         -     -     -     -                                                           -     -   
    SP2:                                                                                                                                                  -     -   
    SP3:                    -     -                                         -     -     -     -                                                                     
    SP4:                                                                                                                                                            
    SP5:                    -     -                                         -     -     -                                                                           

    ExUns: 11c · 11d · 11e ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:  -                                                         
    SP2:  -           -                                             
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for UCKL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    UCKL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGAGATGG
    UCKL1 Expression
    About this image

    UCKL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UCKL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504998

    UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UCKL1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uckl11 , 5 uridine-cytidine kinase 1-like 11, 5 86.19(n)1
    95.52(a)1
      2 (103.66 cM)5
    685561  NM_026765.31  NP_081041.21 
     1815691495 
    chicken
    (Gallus gallus)
    Aves ZNF512B1 zinc finger protein 512B 82.97(n)
    92.14(a)
      419255  NM_001270577.1  NP_001257506.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    93(a)
    1 → many
    4(156004817-156007195)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165392 Xenopus laevis transcribed sequence with moderate similarity more 78.73(n)    BU915533.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570920432   -- 77.96(n)    57092043 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)k012096
    lethal (2) k01209
    52(a)
    1 ↔ 1
    2R(13307938-13313192)
    worm
    (Caenorhabditis elegans)
    Secernentea F19B6.16
    Protein F19B6.1, isoform d
    49(a)
    1 ↔ 1
    IV(12330984-12336041) WBGene00008948
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes URK1(YNR012W)4 Uridine/cytidine kinase, component of the pyrimidine more   --   14(647432-648937) 855746  NP_014409.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UKL51 UKL5 51.89(n)
    46.7(a)
      822365  NM_113659.1  NP_189380.1 


    ENSEMBL Gene Tree for UCKL1 (if available)
    TreeFam Gene Tree for UCKL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UCKL1 gene
    UCK22  UCK12  
    4 SIMAP similar genes for UCKL1 using alignment to 4 protein entries:     UCKL1_HUMAN (see all proteins):
    UCK2    UCK1    UPRT    RP11-311P8.3

    Find genes that share paralogs with UCKL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UCKL1 (see all 311)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2020634881,2
    --62570842(+) CCCCC-/CGCCCAA 2 -- int10--------
    rs768285831,2
    F--62570844(+) CCCCCC/GCAACT 2 -- int11Minor allele frequency- G:0.09WA 118
    rs60112331,2
    C,F,H--62571020(+) GCCCAG/TTTCTA 2 -- int14Minor allele frequency- T:0.01NS NA 506
    rs1474065961,2
    --62571157(+) CACCTC/TTCCTG 2 -- int10--------
    rs2014187241,2
    --62571290(+) GAGGCA/CGGAGG 2 -- ut310--------
    rs1855107841,2
    C--62571298(+) AGGAGG/TGTGGT 2 -- ut310--------
    rs2018328081,2
    --62571349(+) CACTTC/TCTCCT 4 K E mis10--------
    rs713337271,2
    C--62571418(+) AAAAA-/G/GGG 
            
    GGGGG
    4 -- int1 cds12NA CSA 4
    rs2005040391,2
    C,F--62571419(+) AAAAGG/TGGGGG 2 -- int11Minor allele frequency- T:0.01EU 371
    rs352648011,2
    C,F--62571429(+) GGGGGG/-TCCAG 2 -- int12Minor allele frequency- -:0.50NA 4

    HapMap Linkage Disequilibrium report for UCKL1 (62571182 - 62587800 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UCKL1 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509784CNV Insertion20534489
    esv996794CNV Insertion20482838
    nsv913250CNV Loss21882294
    dgv4656n71CNV Loss21882294
    dgv4653n71CNV Loss21882294
    nsv913190CNV Loss21882294
    nsv913287CNV Loss21882294
    nsv913270CNV Loss21882294
    dgv4654n71CNV Loss21882294
    dgv4655n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UCKL1
    DNA2.0 Custom Variant and Variant Library Synthesis for UCKL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610866    OMIM disorders: --


    Find genes that share disorders with UCKL1           About GenesLikeMe


    Export disorders for UCKL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UCKL1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with UCKL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PubMed id 16709802)1, 2, 9 Fortier J.M. and Kornbluth J. (J. Immunol. 2006)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase. (PubMed id 12199906)1, 2 Kashuba E.... Szekely L. (BMC Cell Biol. 2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Downregulation of uridine-cytidine kinase like-1 decreases proliferation and enhances tumor susceptibility to lysis by apoptotic agents and natural killer cells. (PubMed id 19653100)1, 9 Ambrose E.C. and Kornbluth J. (Apoptosis 2009)
    8. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54963 HGNC: 15938 AceView: UCKL1 Ensembl:ENSG00000198276 euGenes: HUgn54963
    ECgene: UCKL1 Kegg: 54963 H-InvDB: UCKL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UCKL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UCKL1 gene:
    Search GeneIP for patents involving UCKL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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