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Aliases for UCKL1 Gene

Aliases for UCKL1 Gene

  • Uridine-Cytidine Kinase 1-Like 1 2 3
  • URKL1 3 4 6
  • EC 4 63
  • UCK1L 3 6
  • Uridine-Cytidine Kinase-Like 1 3
  • Uridine Kinase-Like 1 2
  • UCK1-LIKE 3

External Ids for UCKL1 Gene

Previous HGNC Symbols for UCKL1 Gene

  • URKL1

Previous GeneCards Identifiers for UCKL1 Gene

  • GC20M062041
  • GC20M062571
  • GC20M059304

Summaries for UCKL1 Gene

Entrez Gene Summary for UCKL1 Gene

  • The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for UCKL1 Gene

UCKL1 (Uridine-Cytidine Kinase 1-Like 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glucuronidation. GO annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and uridine kinase activity. An important paralog of this gene is UCK2.

UniProtKB/Swiss-Prot for UCKL1 Gene

  • May contribute to UTP accumulation needed for blast transformation and proliferation.

Gene Wiki entry for UCKL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCKL1 Gene

Genomics for UCKL1 Gene

Regulatory Elements for UCKL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UCKL1 Gene

63,939,829 bp from pter
63,956,447 bp from pter
16,619 bases
Minus strand

Genomic View for UCKL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UCKL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCKL1 Gene

Proteins for UCKL1 Gene

  • Protein details for UCKL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uridine-cytidine kinase-like 1
    Protein Accession:
    Secondary Accessions:
    • B7Z8N2
    • Q5JWV0
    • Q70AQ5
    • Q8N524
    • Q9H3Z2

    Protein attributes for UCKL1 Gene

    548 amino acids
    Molecular mass:
    61141 Da
    Quaternary structure:
    • Interacts with RNF19B and EBV EBNA3.

    Alternative splice isoforms for UCKL1 Gene


neXtProt entry for UCKL1 Gene

Proteomics data for UCKL1 Gene at MOPED

Selected DME Specific Peptides for UCKL1 Gene

Post-translational modifications for UCKL1 Gene

  • Ubiquitinated by RNF19B; which induces proteasomal degradation.
  • Ubiquitination at Lys111, Lys387, and Lys392
  • Modification sites at PhosphoSitePlus

Other Protein References for UCKL1 Gene

Antibody Products

Domains for UCKL1 Gene

Protein Domains for UCKL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the uridine kinase family.
  • Belongs to the uridine kinase family.
genes like me logo Genes that share domains with UCKL1: view

No data available for Gene Families for UCKL1 Gene

Function for UCKL1 Gene

Molecular function for UCKL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + uridine = ADP + UMP
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + cytidine = ADP + CMP
UniProtKB/Swiss-Prot Function:
May contribute to UTP accumulation needed for blast transformation and proliferation.

Enzyme Numbers (IUBMB) for UCKL1 Gene

Gene Ontology (GO) - Molecular Function for UCKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004849 uridine kinase activity IEA --
GO:0005515 protein binding IPI 12199906
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
GO:0016740 transferase activity --
genes like me logo Genes that share ontologies with UCKL1: view

Phenotypes for UCKL1 Gene

genes like me logo Genes that share phenotypes with UCKL1: view

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UCKL1 Gene

Localization for UCKL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCKL1 Gene

Cytoplasm. Nucleus. Note=EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location.

Subcellular locations from

Jensen Localization Image for UCKL1 Gene COMPARTMENTS Subcellular localization image for UCKL1 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
cytosol 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UCKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UCKL1: view

Pathways for UCKL1 Gene

genes like me logo Genes that share pathways with UCKL1: view

Pathways by source for UCKL1 Gene

UniProtKB/Swiss-Prot Q9NWZ5-UCKL1_HUMAN

  • Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
  • Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1

Gene Ontology (GO) - Biological Process for UCKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0016032 viral process IEA --
GO:0016310 phosphorylation IEA --
GO:0044206 UMP salvage IEA --
GO:0044211 CTP salvage IEA --
genes like me logo Genes that share ontologies with UCKL1: view

Drugs for UCKL1 Gene

(4) Drugbank Compounds for UCKL1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Alpha-Phosphoribosylpyrophosphoric Acid
  • 5-Phospho-alpha-D-ribose 1-diphosphate
13270-65-0 7339 Target experimental
86-01-1 6335984 Target experimental
66-22-8 1174 Target experimental
58-97-9 6101904 Target experimental

(27) HMDB Compounds for UCKL1 Gene

Compound Synonyms Cas Number PubMed IDs
5-Fluorouridine monophosphate
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
  • 1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine
genes like me logo Genes that share compounds with UCKL1: view

Transcripts for UCKL1 Gene

Unigene Clusters for UCKL1 Gene

Uridine-cytidine kinase 1-like 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UCKL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCKL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ·
SP1: - - - - - - - -
SP2: - -
SP3: - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: -
SP8: - - - -
SP9: - -
SP10: - - -
SP14: - -
SP15: - -
SP16: -
SP17: -

ExUns: 11c · 11d · 11e ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: -
SP2: - -
SP12: -

Relevant External Links for UCKL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UCKL1 Gene

mRNA expression in normal human tissues for UCKL1 Gene

Protein differential expression in normal tissues for UCKL1 Gene

This gene is overexpressed in Plasma (31.0), Monocytes (13.2), and Salivary gland (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UCKL1 Gene

SOURCE GeneReport for Unigene cluster for UCKL1 Gene Hs.504998

mRNA Expression by UniProt/SwissProt for UCKL1 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with UCKL1: view

Expression partners for UCKL1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UCKL1 Gene

Orthologs for UCKL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCKL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UCKL1 35
  • 86.88 (n)
  • 95.48 (a)
UCKL1 36
  • 95 (a)
(Canis familiaris)
Mammalia UCKL1 35
  • 88.49 (n)
  • 94.91 (a)
UCKL1 36
  • 94 (a)
(Mus musculus)
Mammalia Uckl1 35
  • 86.19 (n)
  • 95.52 (a)
Uckl1 16
Uckl1 36
  • 95 (a)
(Pan troglodytes)
Mammalia UCKL1 35
  • 91.99 (n)
  • 91.41 (a)
UCKL1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Uckl1 35
  • 87.06 (n)
  • 94.96 (a)
(Monodelphis domestica)
Mammalia UCKL1 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
-- 36
  • 94 (a)
(Gallus gallus)
Aves ZNF512B 35
  • 82.97 (n)
  • 92.14 (a)
ZNF512B 36
  • 87 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5693 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16539 35
(Danio rerio)
Actinopterygii uckl1b 35
  • 77.11 (n)
  • 85.03 (a)
uckl1a 36
  • 75 (a)
uckl1b 36
  • 81 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1186 35
fruit fly
(Drosophila melanogaster)
Insecta l(2)k01209 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea F19B6.1 36
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URK1 36
  • 35 (a)
URK1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons UKL5 35
  • 51.89 (n)
  • 46.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
Species with no ortholog for UCKL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UCKL1 Gene

Gene Tree for UCKL1 (if available)
Gene Tree for UCKL1 (if available)

Paralogs for UCKL1 Gene

Paralogs for UCKL1 Gene

(4) SIMAP similar genes for UCKL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UCKL1: view

Variants for UCKL1 Gene

Sequence variations from dbSNP and Humsavar for UCKL1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs545408314 -- 63,939,840(+) TTTCT(A/G)AAGCT utr-variant-3-prime, nc-transcript-variant
rs545242047 -- 63,947,866(+) GGACC(A/G)GCACT intron-variant
rs545079894 -- 63,948,043(+) AGAGG(C/T)TCAGA intron-variant
rs545054596 -- 63,945,134(+) GGCGA(A/G)TTTAG intron-variant
rs544805573 -- 63,946,843(+) GAGGC(C/T)GAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UCKL1 Gene

Variant ID Type Subtype PubMed ID
nsv913190 CNV Loss 21882294
nsv428381 CNV Gain+Loss 18775914
nsv913250 CNV Loss 21882294
nsv509784 CNV Insertion 20534489
nsv913269 CNV Loss 21882294
nsv469773 CNV Gain 16826518
nsv913270 CNV Loss 21882294
dgv4652n71 CNV Loss 21882294
dgv4653n71 CNV Loss 21882294
dgv4654n71 CNV Loss 21882294
dgv4655n71 CNV Loss 21882294
dgv4656n71 CNV Loss 21882294
esv29498 CNV Gain 19812545
nsv913285 CNV Gain 21882294
esv996794 CNV Insertion 20482838
nsv913287 CNV Loss 21882294

Relevant External Links for UCKL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCKL1 Gene

Disorders for UCKL1 Gene

No disorders were found for UCKL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for UCKL1 Gene

Publications for UCKL1 Gene

  1. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PMID: 16709802) Fortier J.M. … Kornbluth J. (J. Immunol. 2006) 3 4 23
  2. Downregulation of uridine-cytidine kinase like-1 decreases proliferation and enhances tumor susceptibility to lysis by apoptotic agents and natural killer cells. (PMID: 19653100) Ambrose E.C. … Kornbluth J. (Apoptosis 2009) 3 23
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase. (PMID: 12199906) Kashuba E. … Szekely L. (BMC Cell Biol. 2002) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for UCKL1 Gene

Sources for UCKL1 Gene

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