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Aliases for UCKL1 Gene

Aliases for UCKL1 Gene

  • Uridine-Cytidine Kinase 1 Like 1 2 3
  • Uridine-Cytidine Kinase 1-Like 1 2 3 5
  • EC 2.7.1.48 4 63
  • URKL1 3 4
  • Uridine Kinase-Like 1 2
  • UCK1-LIKE 3
  • UCK1L 3

External Ids for UCKL1 Gene

Previous HGNC Symbols for UCKL1 Gene

  • URKL1

Previous GeneCards Identifiers for UCKL1 Gene

  • GC20M062041
  • GC20M062571
  • GC20M059304

Summaries for UCKL1 Gene

Entrez Gene Summary for UCKL1 Gene

  • The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for UCKL1 Gene

UCKL1 (Uridine-Cytidine Kinase 1 Like 1) is a Protein Coding gene. Among its related pathways are Metabolism and Pyrimidine metabolism (KEGG). GO annotations related to this gene include kinase activity and uridine kinase activity. An important paralog of this gene is UCK2.

UniProtKB/Swiss-Prot for UCKL1 Gene

  • May contribute to UTP accumulation needed for blast transformation and proliferation.

Gene Wiki entry for UCKL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCKL1 Gene

Genomics for UCKL1 Gene

Regulatory Elements for UCKL1 Gene

Genomic Location for UCKL1 Gene

Chromosome:
20
Start:
63,939,829 bp from pter
End:
63,959,435 bp from pter
Size:
19,607 bases
Orientation:
Minus strand

Genomic View for UCKL1 Gene

Genes around UCKL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCKL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCKL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCKL1 Gene

Proteins for UCKL1 Gene

  • Protein details for UCKL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWZ5-UCKL1_HUMAN
    Recommended name:
    Uridine-cytidine kinase-like 1
    Protein Accession:
    Q9NWZ5
    Secondary Accessions:
    • B7Z8N2
    • Q5JWV0
    • Q70AQ5
    • Q8N524
    • Q9H3Z2

    Protein attributes for UCKL1 Gene

    Size:
    548 amino acids
    Molecular mass:
    61141 Da
    Quaternary structure:
    • Interacts with RNF19B and EBV EBNA3.

    Alternative splice isoforms for UCKL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UCKL1 Gene

Proteomics data for UCKL1 Gene at MOPED

Selected DME Specific Peptides for UCKL1 Gene

Post-translational modifications for UCKL1 Gene

  • Ubiquitinated by RNF19B; which induces proteasomal degradation.
  • Ubiquitination at Lys 111, Lys 387, and Lys 392
  • Modification sites at PhosphoSitePlus

Other Protein References for UCKL1 Gene

Antibody Products

Domains & Families for UCKL1 Gene

Protein Domains for UCKL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWZ5

UniProtKB/Swiss-Prot:

UCKL1_HUMAN :
  • Belongs to the uridine kinase family.
Family:
  • Belongs to the uridine kinase family.
genes like me logo Genes that share domains with UCKL1: view

No data available for Gene Families for UCKL1 Gene

Function for UCKL1 Gene

Molecular function for UCKL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + uridine = ADP + UMP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + cytidine = ADP + CMP.
UniProtKB/Swiss-Prot Function:
May contribute to UTP accumulation needed for blast transformation and proliferation.

Enzyme Numbers (IUBMB) for UCKL1 Gene

genes like me logo Genes that share phenotypes with UCKL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UCKL1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UCKL1 Gene

Localization for UCKL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCKL1 Gene

Cytoplasm. Nucleus. Note=EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCKL1 Gene COMPARTMENTS Subcellular localization image for UCKL1 gene
Compartment Confidence
cytosol 5
nucleus 4
endoplasmic reticulum 3
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for UCKL1 Gene

Pathways & Interactions for UCKL1 Gene

genes like me logo Genes that share pathways with UCKL1: view

Pathways by source for UCKL1 Gene

UniProtKB/Swiss-Prot Q9NWZ5-UCKL1_HUMAN

  • Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.
  • Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.

Gene Ontology (GO) - Biological Process for UCKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process IBA --
GO:0016032 viral process IEA --
GO:0044211 CTP salvage IEA --
genes like me logo Genes that share ontologies with UCKL1: view

No data available for SIGNOR curated interactions for UCKL1 Gene

Drugs & Compounds for UCKL1 Gene

(16) Drugs for UCKL1 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Guanosine triphosphate Experimental Pharma Target 0
Uracil Experimental Pharma Target 0
Uridine-5'-Monophosphate Experimental Pharma Target 0
Phosphoribosyl pyrophosphate Experimental Pharma Target 0

(12) Additional Compounds for UCKL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Fluorouridine monophosphate
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
63-37-6
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
genes like me logo Genes that share compounds with UCKL1: view

Transcripts for UCKL1 Gene

Unigene Clusters for UCKL1 Gene

Uridine-cytidine kinase 1-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCKL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ·
SP1: - - - - - - - -
SP2: - -
SP3: - - - - - -
SP4:
SP5: - - - - -
SP6: - - - -
SP7: -
SP8: - - - -
SP9: - -
SP10: - - -
SP11:
SP12:
SP13:
SP14: - -
SP15: - -
SP16: -
SP17: -

ExUns: 11c · 11d · 11e ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for UCKL1 Gene

GeneLoc Exon Structure for
UCKL1
ECgene alternative splicing isoforms for
UCKL1

Expression for UCKL1 Gene

mRNA expression in normal human tissues for UCKL1 Gene

Protein differential expression in normal tissues from HIPED for UCKL1 Gene

This gene is overexpressed in Plasma (31.0), Monocytes (13.2), and Salivary gland (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UCKL1 Gene



SOURCE GeneReport for Unigene cluster for UCKL1 Gene Hs.504998

mRNA Expression by UniProt/SwissProt for UCKL1 Gene

Q9NWZ5-UCKL1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with UCKL1: view

Protein tissue co-expression partners for UCKL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UCKL1 Gene

Orthologs for UCKL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCKL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UCKL1 35
  • 86.88 (n)
  • 95.48 (a)
UCKL1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCKL1 35
  • 88.49 (n)
  • 94.91 (a)
UCKL1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uckl1 35
  • 86.19 (n)
  • 95.52 (a)
Uckl1 16
Uckl1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UCKL1 35
  • 91.99 (n)
  • 91.41 (a)
UCKL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uckl1 35
  • 87.06 (n)
  • 94.96 (a)
oppossum
(Monodelphis domestica)
Mammalia UCKL1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZNF512B 35
  • 82.97 (n)
  • 92.14 (a)
ZNF512B 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5693 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16539 35
zebrafish
(Danio rerio)
Actinopterygii uckl1b 35
  • 77.11 (n)
  • 85.03 (a)
uckl1a 36
  • 75 (a)
OneToMany
uckl1b 36
  • 81 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1186 35
fruit fly
(Drosophila melanogaster)
Insecta l(2)k01209 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F19B6.1 36
  • 49 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URK1 36
  • 35 (a)
OneToMany
URK1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons UKL5 35
  • 51.89 (n)
  • 46.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for UCKL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UCKL1 Gene

ENSEMBL:
Gene Tree for UCKL1 (if available)
TreeFam:
Gene Tree for UCKL1 (if available)

Paralogs for UCKL1 Gene

Paralogs for UCKL1 Gene

(4) SIMAP similar genes for UCKL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UCKL1: view

Variants for UCKL1 Gene

Sequence variations from dbSNP and Humsavar for UCKL1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs751327 -- 63,946,260(+) CCGCC(C/T)CCCAA nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs817310 -- 63,949,289(+) GAGGG(C/G)GGCCC intron-variant
rs817311 -- 63,949,375(+) GCTGC(A/G)GCTGG intron-variant
rs817312 -- 63,950,076(+) GCCAG(A/G)CGCTG intron-variant
rs817313 -- 63,951,034(+) CCGGG(G/T)GGCTG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for UCKL1 Gene

Variant ID Type Subtype PubMed ID
nsv913190 CNV Loss 21882294
nsv428381 CNV Gain+Loss 18775914
nsv913250 CNV Loss 21882294
nsv509784 CNV Insertion 20534489
nsv913269 CNV Loss 21882294
nsv469773 CNV Gain 16826518
nsv913270 CNV Loss 21882294
dgv4652n71 CNV Loss 21882294
dgv4653n71 CNV Loss 21882294
dgv4654n71 CNV Loss 21882294
dgv4655n71 CNV Loss 21882294
dgv4656n71 CNV Loss 21882294
esv29498 CNV Gain 19812545
nsv913285 CNV Gain 21882294
esv996794 CNV Insertion 20482838
nsv913287 CNV Loss 21882294

Variation tolerance for UCKL1 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UCKL1 Gene

HapMap Linkage Disequilibrium report
UCKL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCKL1 Gene

Disorders for UCKL1 Gene

Relevant External Links for UCKL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UCKL1

No disorders were found for UCKL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UCKL1 Gene

Publications for UCKL1 Gene

  1. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PMID: 16709802) Fortier J.M. … Kornbluth J. (J. Immunol. 2006) 3 4 23 67
  2. Downregulation of uridine-cytidine kinase like-1 decreases proliferation and enhances tumor susceptibility to lysis by apoptotic agents and natural killer cells. (PMID: 19653100) Ambrose E.C. … Kornbluth J. (Apoptosis 2009) 3 23
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26

Products for UCKL1 Gene

Sources for UCKL1 Gene

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