Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UCKL1 Gene

protein-coding   GIFtS: 59
GCID: GC20M062571

Uridine-Cytidine Kinase 1-Like 1

(Previous name: uridine kinase-like 1)
(Previous symbol: URKL1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Uridine-Cytidine Kinase 1-Like 11 2     UCK1L2 5
URKL11 2 3 5     UCK1-LIKE2
Uridine Kinase-Like 11 2     Uridine-Cytidine Kinase-Like 12
EC 2.7.1.483 8     

External Ids:    HGNC: 159381   Entrez Gene: 549632   Ensembl: ENSG000001982767   OMIM: 6108665   UniProtKB: Q9NWZ53   

Export aliases for UCKL1 gene to outside databases

Previous GC identifers: GC20M062041 GC20M059304


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UCKL1 Gene: 
UCKL1 (uridine-cytidine kinase 1-like 1) is a protein-coding gene. Diseases associated with UCKL1 include alcoholism, and pneumonia, and among its related super-pathways are Metabolism and Purine metabolism. GO annotations related to this gene include uridine kinase activity and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is UCK2.

UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5
Function: May contribute to UTP accumulation needed for blast transformation and proliferation

Gene Wiki entry for UCKL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011333.6  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UCKL1 gene promoter:
         AhR   Lmo2   LUN-1   AP-4   CUTL1   Arnt   FOXL1   HOXA5   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCKL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for UCKL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCKL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

UCKL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCKL1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M062571:  view genomic region     (about GC identifiers)

Start:
62,571,182 bp from pter      End:
62,587,800 bp from pter
Size:
16,619 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5 (See protein sequence)
Recommended Name: Uridine-cytidine kinase-like 1  
Size: 548 amino acids; 61141 Da
Subunit: Interacts with RNF19B and EBV EBNA3
Subcellular location: Cytoplasm. Nucleus. Note=EBNA3 induces isoform 1 translocation to the nucleus, whereas it
does change isoform 3 location
Secondary accessions: B7Z8N2 Q5JWV0 Q70AQ5 Q8N524 Q9H3Z2
Alternative splicing: 4 isoforms:  Q9NWZ5-1   Q9NWZ5-2   Q9NWZ5-3   Q9NWZ5-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UCKL1: NX_Q9NWZ5

Explore proteomics data for UCKL1 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by RNF19B; which induces proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NWZ5

  • 2 DME Specific Peptides for UCKL1 (Q9NWZ5)
     DHPDAFD  NTVAIDL 

    UCKL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UCKL1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001180308.1  NP_060329.2  

    ENSEMBL proteins: 
     ENSP00000346155   ENSP00000358924   ENSP00000402994   ENSP00000358908   ENSP00000351546  

    Human Recombinant Protein Products for UCKL1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for UCKL1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for UCKL1
    GenScript Custom Purified and Recombinant Proteins Services for UCKL1
    Novus Biologicals UCKL1 Protein
    Novus Biologicals UCKL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UCKL1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum IDA--

    UCKL1 for ontologies           About GeneDecksing



    UCKL1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UCKL1
    OriGene Custom Antibody Services for UCKL1
    GenScript Custom Superior Antibodies Services for UCKL1
    Novus Biologicals UCKL1 Antibodies
    Abcam antibodies for UCKL1
    Cloud-Clone Corp. Antibodies for UCKL1 
    ThermoFisher Antibodies for UCKL1
    LSBio Antibodies in human, mouse, rat for UCKL1 

    Assay Products for UCKL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UCKL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UCKL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UCKL1 
    Cloud-Clone Corp. CLIAs for UCKL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR000764 Uridine_kinase
     IPR006083 PRK/URK

    Graphical View of Domain Structure for InterPro Entry Q9NWZ5

    ProtoNet protein and cluster: Q9NWZ5

    1 Blocks protein domain: IPB000764 Uridine kinase signature

    UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5
    Similarity: Belongs to the uridine kinase family


    UCKL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UCKL1_HUMAN, Q9NWZ5
    Function: May contribute to UTP accumulation needed for blast transformation and proliferation
    Catalytic activity: ATP + uridine = ADP + UMP
    Catalytic activity: ATP + cytidine = ADP + CMP

         Enzyme Number (IUBMB): EC 2.7.1.481 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004849uridine kinase activity IEA--
    GO:0005515protein binding IPI16709802
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0016740transferase activity ----
         
    UCKL1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for UCKL1:
     G0/1 arrest  Increased G1 DNA content  Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UCKL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UCKL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UCKL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UCKL1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCKL1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate UCKL1:
    hsa-miR-3163 hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidUCKL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UCKL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCKL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UCKL1
    Sirion Biotech Customized adenovirus for overexpression of UCKL1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UCKL1 (see all 11)
    OriGene ORF clones in mouse, rat for UCKL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UCKL1 (NM_017859)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCKL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCKL1
    Sirion Biotech Customized lentivirus for stable overexpression of UCKL1 
                         Customized lentivirus expression plasmids for stable overexpression of UCKL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UCKL1
    Search LifeMap BioReagents cell lines for UCKL1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCKL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UCKL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Purine metabolism
    Pyrimidine metabolism0.38
    3Glucuronidation
    Drug metabolism - other enzymes0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3         Kegg Pathways  (Kegg details for UCKL1):
        Pyrimidine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways

    UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5
    Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
    Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1


    UCKL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UCKL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for UCKL1 (Q9NWZ51, 3 ENSP000003461554) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF19BQ6ZMZ01, 3, ENSP000003625554EBI-2466660,EBI-2466594 I2D: score=1 STRING: ENSP00000362555
    EIF2B2P497703I2D: score=2 
    GPT2Q8TD303I2D: score=1 
    HSP90AA1P079003I2D: score=1 
    HUWE1Q7Z6Z73I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0044206UMP salvage IEA--
    GO:0044211CTP salvage IEA--

    UCKL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UCKL1

    10/22 HMDB Compounds for UCKL1 (see all 22)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cytidine1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)65-46-3--
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Deoxycytidine1-(2-Deoxy-b-D-ribofuranosyl)cytosine (see all 15)951-77-9--
    Deoxyuridine1-(2-Deoxy-D-erythro-pentofuranosyl)uracil (see all 12)951-78-0--
    Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--

    4 DrugBank Compounds for UCKL1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-Phosphoribosylpyrophosphoric Acid-- 13270-65-0target--17139284 17016423 10592235
    Guanosine-5'-Triphosphate-- 86-01-1target--17139284 17016423 10592235
    Uracil-- 66-22-8target--17139284 17016423 10592235
    Uridine-5'-Monophosphate-- 58-97-9target--17139284 17016423 10592235

    Search CenterWatch for drugs/clinical trials and news about UCKL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UCKL1 gene (2 alternative transcripts): 
    NM_001193379.1  NM_017859.3  

    Unigene Cluster for UCKL1:

    Uridine-cytidine kinase 1-like 1
    Hs.504998  [show with all ESTs]
    Unigene Representative Sequence: AK128082
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354216(uc010gkn.3 uc011abn.2 uc011abo.2) ENST00000369908(uc011abm.2)
    ENST00000430743 ENST00000492660 ENST00000483710 ENST00000369892 ENST00000358711

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCKL1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate UCKL1:
    hsa-miR-3163 hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidUCKL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UCKL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCKL1
    Clone
    Products:
         
    OriGene clones in human, mouse for UCKL1 (see all 11)
    OriGene ORF clones in mouse, rat for UCKL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UCKL1 (NM_017859)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCKL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCKL1
    Sirion Biotech Customized lentivirus for stable overexpression of UCKL1 
                         Customized lentivirus expression plasmids for stable overexpression of UCKL1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for UCKL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UCKL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCKL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCKL1

    Additional mRNA sequence: 

    AJ605558.1 AK000524.1 AK128082.1 AK222559.1 AK223220.1 AK301602.1 AK303688.1 BC033078.1 

    22 DOTS entries:

    DT.97817341  DT.95204026  DT.211623  DT.120803977  DT.75102038  DT.95173576  DT.95114287  DT.75109769 
    DT.209710  DT.120803978  DT.120803982  DT.100709734  DT.95173580  DT.100811435  DT.75118267  DT.100786530 
    DT.65287100  DT.95140900  DT.209709  DT.95256609  DT.120804018  DT.91741721 

    24/172 AceView cDNA sequences (see all 172):

    BQ637053 AA516005 BQ640057 AW079506 AI478287 CK429822 BM127708 BM693202 
    AI589345 AI979128 AI744038 AW236555 CF127698 BE501778 AI953030 BE304354 
    BE501787 F27242 BM021921 BM702108 AI364501 AI738474 BU730779 BI963021 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for UCKL1 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ·
    SP1:                    -     -                                         -     -     -     -                                                           -     -   
    SP2:                                                                                                                                                  -     -   
    SP3:                    -     -                                         -     -     -     -                                                                     
    SP4:                                                                                                                                                            
    SP5:                    -     -                                         -     -     -                                                                           

    ExUns: 11c · 11d · 11e ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:  -                                                         
    SP2:  -           -                                             
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for UCKL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UCKL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGAGATGG
    UCKL1 Expression
    About this image


    See UCKL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UCKL1

    SOURCE GeneReport for Unigene cluster: Hs.504998

    UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for UCKL1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for UCKL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UCKL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCKL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCKL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCKL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UCKL1 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uckl11 , 5 uridine-cytidine kinase 1-like 11, 5 85.83(n)1
    94.89(a)1
      2 (103.66 cM)5
    685561  NM_026765.31  NP_081041.21 
     1815691495 
    chicken
    (Gallus gallus)
    Aves UCKL11 uridine-cytidine kinase 1-like 1 82.97(n)
    92.14(a)
      771616  XM_001234873.2  XP_001234874.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    93(a)
    84(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    4(156004817-156007195)
    4(155965561-155967312)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165392 Xenopus laevis transcribed sequence with moderate similarity more 78.73(n)    BU915533.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570920432   -- 77.96(n)    57092043 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)k012096
    lethal (2) k01209
    49(a)
    1 ↔ 1
    2R(13307938-13313192)
    worm
    (Caenorhabditis elegans)
    Secernentea F19B6.16
    Protein F19B6.1, isoform b
    47(a)
    1 ↔ 1
    IV(12330984-12336041)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes URK1(YNR012W)4 Uridine/cytidine kinase, component of the pyrimidine more   --   14(647432-648937) 855746  NP_014409.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UKL51 putative uracil phosphoribosyltransferase 51.97(n)
    46.7(a)
      822365  NM_113659.1  NP_189380.1 


    ENSEMBL Gene Tree for UCKL1 (if available)
    TreeFam Gene Tree for UCKL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UCKL1 gene
    UCK22  UCK12  
    4 SIMAP similar genes for UCKL1 using alignment to 4 protein entries:     UCKL1_HUMAN (see all proteins):
    UCK2    UCK1    UPRT    RP11-311P8.3

    UCKL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/311 SNPs in UCKL1 are shown (see all 311)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2020634881,2
    --62570842(+) CCCCC-/CGCCCAA 2 -- int10--------
    rs768285831,2
    F--62570844(+) CCCCCC/GCAACT 2 -- int11Minor allele frequency- G:0.09WA 118
    rs60112331,2
    C,F,H--62571020(+) GCCCAG/TTTCTA 2 -- int14Minor allele frequency- T:0.01NS NA 506
    rs1474065961,2
    --62571157(+) CACCTC/TTCCTG 2 -- int10--------
    rs2014187241,2
    --62571290(+) GAGGCA/CGGAGG 2 -- ut310--------
    rs1855107841,2
    C--62571298(+) AGGAGG/TGTGGT 2 -- ut310--------
    rs2018328081,2
    --62571349(+) CACTTC/TCTCCT 4 K E mis10--------
    rs713337271,2
    C--62571418(+) AAAAA-/G/GGG 
            
    GGGGG
    4 -- int1 cds12NA CSA 4
    rs2005040391,2
    C,F--62571419(+) AAAAGG/TGGGGG 2 -- int11Minor allele frequency- T:0.01EU 371
    rs352648011,2
    C,F--62571429(+) GGGGGG/-TCCAG 2 -- int12Minor allele frequency- -:0.50NA 4

    HapMap Linkage Disequilibrium report for UCKL1 (62571182 - 62587800 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for UCKL1 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509784CNV Insertion20534489
    esv996794CNV Insertion20482838
    nsv913250CNV Loss21882294
    dgv4656n71CNV Loss21882294
    dgv4653n71CNV Loss21882294
    nsv913190CNV Loss21882294
    nsv913287CNV Loss21882294
    nsv913270CNV Loss21882294
    dgv4654n71CNV Loss21882294
    dgv4655n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UCKL1
    DNA2.0 Custom Variant and Variant Library Synthesis for UCKL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610866    OMIM disorders: --

    2 diseases for UCKL1:    About MalaCards
    alcoholism    pneumonia


    UCKL1 for disorders           About GeneDecksing


    Export disorders for UCKL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UCKL1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with UCKL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PubMed id 16709802)1, 2, 9 Fortier J.M. and Kornbluth J. (2006)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase. (PubMed id 12199906)1, 2 Kashuba E.... Szekely L. (2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Downregulation of uridine-cytidine kinase like-1 decr eases proliferation and enhances tumor susceptibility to lysis by apoptotic age nts and natural killer cells. (PubMed id 19653100)1, 9 Ambrose E.C. and Kornbluth J. (2009)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54963 HGNC: 15938 AceView: UCKL1 Ensembl:ENSG00000198276 euGenes: HUgn54963
    ECgene: UCKL1 Kegg: 54963 H-InvDB: UCKL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UCKL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UCKL1 gene:
    Search GeneIP for patents involving UCKL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UCKL1   OriGene RNAi products in human, mouse, rat for UCKL1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for UCKL1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UCKL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for UCKL1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for UCKL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UCKL1   OriGene Custom Protein Services for UCKL1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UCKL1
     QIAGEN SeqTarget long-range PCR primers for resequencing UCKL1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCKL1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCKL1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCKL1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCKL1
     GenScript Custom Purified and Recombinant Proteins Services for UCKL1 GenScript cDNA clones with any tag delivered in your preferred vector for UCKL1
     GenScript Custom Assay Services for UCKL1 GenScript Custom Superior Antibodies Services for UCKL1
     GenScript Custom overexpressing Cell Line Services for UCKL1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UCKL1 promoter
     Search Chromatin IP Primers for UCKL1
     RT2 qPCR Primer Assay in human, mouse, rat UCKL1
     Search GNC Networks for UCKL1
     SABiosciences Custom PCR Arrays for UCKL1
     Search Tocris compounds for UCKL1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UCKL1 antibodies
     UCKL1 proteins
     UCKL1 lysates
     Antibodies for UCKL1
     See all of Abcam's Antibodies, Kits and Proteins for UCKL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for UCKL1
     Antibodies for UCKL1
     ELISAs for UCKL1
     CLIAs for UCKL1
     Search LifeMap BioReagents cell lines for UCKL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCKL1
     SwitchGear 3'UTR luciferase reporter plasmids for UCKL1
     SwitchGear Promoter luciferase reporter plasmids for UCKL1
     ThermoFisher Antibodies for UCKL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCKL1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for UCKL1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UCKL1
    Customized:
     lentivirus for stable overexpression of UCKL1
     lentivirus expression plasmids for stable overexpression of UCKL1
     adenovirus for overexpression of UCKL1
     LSBio Antibodies in human, mouse, rat for UCKL1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UCKL1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4