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Aliases for UCKL1 Gene

Aliases for UCKL1 Gene

  • Uridine-Cytidine Kinase 1 Like 1 2 3 5
  • EC 4 61
  • URKL1 3 4
  • Uridine-Cytidine Kinase 1-Like 1 2
  • Uridine-Cytidine Kinase-Like 1 3
  • Uridine Kinase-Like 1 2
  • UCK1-LIKE 3
  • UCK1L 3

External Ids for UCKL1 Gene

Previous HGNC Symbols for UCKL1 Gene

  • URKL1

Previous GeneCards Identifiers for UCKL1 Gene

  • GC20M062041
  • GC20M062571
  • GC20M059304

Summaries for UCKL1 Gene

Entrez Gene Summary for UCKL1 Gene

  • The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for UCKL1 Gene

UCKL1 (Uridine-Cytidine Kinase 1 Like 1) is a Protein Coding gene. Among its related pathways are Porphyrin and chlorophyll metabolism and Purine metabolism (KEGG). GO annotations related to this gene include kinase activity and uridine kinase activity. An important paralog of this gene is UCK2.

UniProtKB/Swiss-Prot for UCKL1 Gene

  • May contribute to UTP accumulation needed for blast transformation and proliferation.

Gene Wiki entry for UCKL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCKL1 Gene

Genomics for UCKL1 Gene

Regulatory Elements for UCKL1 Gene

Enhancers for UCKL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G063845 1.6 Ensembl ENCODE dbSUPER 25.7 +112.1 112109 3.3 HDGF FOXA2 PKNOX1 ARNT AGO1 ARID4B SIN3A YBX1 FEZF1 DMAP1 TNFRSF6B PCMTD2 MIR647 RTEL1 ZNF512B UCKL1 ZBTB46-AS1 DNAJC5 PRPF6 C20orf204
GH20G063953 1.4 ENCODE dbSUPER 23.3 +2.9 2928 5.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 RTEL1 UCKL1 TNFRSF6B PRPF6 MIR647 STMN3 HAR1A ZBTB46 ZNF512B PIR62018
GH20G063680 1.5 Ensembl ENCODE dbSUPER 14.8 +272.1 272133 13.3 HDGF PKNOX1 AGO1 ZFP64 SIN3A ZBTB7B ZNF548 FOS DEK ZNF263 LIME1 RTEL1 MIR647 UCKL1 ENSG00000237371 ZGPAT SLC2A4RG ENSG00000229299 FNDC11 SRMS
GH20G064062 1.7 Ensembl ENCODE dbSUPER 11.9 -105.4 -105412 5.3 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC RGS19 RTEL1 TNFRSF6B ARFGAP1 MIR647 ZNF512B PRPF6 UCKL1 TCEA2 C20orf204
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UCKL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UCKL1 Gene

63,939,829 bp from pter
63,959,435 bp from pter
19,607 bases
Minus strand

Genomic View for UCKL1 Gene

Genes around UCKL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCKL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCKL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCKL1 Gene

Proteins for UCKL1 Gene

  • Protein details for UCKL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uridine-cytidine kinase-like 1
    Protein Accession:
    Secondary Accessions:
    • B7Z8N2
    • Q5JWV0
    • Q70AQ5
    • Q8N524
    • Q9H3Z2

    Protein attributes for UCKL1 Gene

    548 amino acids
    Molecular mass:
    61141 Da
    Quaternary structure:
    • Interacts with RNF19B and EBV EBNA3.

    Alternative splice isoforms for UCKL1 Gene


neXtProt entry for UCKL1 Gene

Selected DME Specific Peptides for UCKL1 Gene


Post-translational modifications for UCKL1 Gene

  • Ubiquitinated by RNF19B; which induces proteasomal degradation.
  • Ubiquitination at isoforms=2, 3, 4111, Lys387, and posLast=392392
  • Modification sites at PhosphoSitePlus

Domains & Families for UCKL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the uridine kinase family.
  • Belongs to the uridine kinase family.
genes like me logo Genes that share domains with UCKL1: view

No data available for Gene Families for UCKL1 Gene

Function for UCKL1 Gene

Molecular function for UCKL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + uridine = ADP + UMP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + cytidine = ADP + CMP.
UniProtKB/Swiss-Prot Function:
May contribute to UTP accumulation needed for blast transformation and proliferation.

Enzyme Numbers (IUBMB) for UCKL1 Gene

Gene Ontology (GO) - Molecular Function for UCKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004849 uridine kinase activity IBA,TAS --
GO:0005515 protein binding IPI 12199906
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UCKL1: view
genes like me logo Genes that share phenotypes with UCKL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UCKL1

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UCKL1 Gene

Localization for UCKL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCKL1 Gene

Cytoplasm. Nucleus. Note=EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UCKL1 gene
Compartment Confidence
cytosol 5
nucleus 4
endoplasmic reticulum 3
plasma membrane 1
lysosome 1

Gene Ontology (GO) - Cellular Components for UCKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IBA --
genes like me logo Genes that share ontologies with UCKL1: view

Pathways & Interactions for UCKL1 Gene

genes like me logo Genes that share pathways with UCKL1: view

Pathways by source for UCKL1 Gene

UniProtKB/Swiss-Prot Q9NWZ5-UCKL1_HUMAN

  • Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.
  • Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.

Gene Ontology (GO) - Biological Process for UCKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process IBA --
GO:0006222 UMP biosynthetic process IEA --
GO:0008152 metabolic process IEA --
GO:0009116 nucleoside metabolic process IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with UCKL1: view

No data available for SIGNOR curated interactions for UCKL1 Gene

Drugs & Compounds for UCKL1 Gene

(17) Drugs for UCKL1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Guanosine triphosphate Experimental Pharma Target 0
Uracil Experimental Pharma Target 0
Uridine-5'-Monophosphate Experimental Pharma Target 0
Alpha-Phosphoribosylpyrophosphoric Acid Experimental Pharma Target 0

(11) Additional Compounds for UCKL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Fluorouridine monophosphate
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
genes like me logo Genes that share compounds with UCKL1: view

Transcripts for UCKL1 Gene

Unigene Clusters for UCKL1 Gene

Uridine-cytidine kinase 1-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCKL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ·
SP1: - - - - - - - -
SP2: - -
SP3: - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: -
SP8: - - - -
SP9: - -
SP10: - - -
SP14: - -
SP15: - -
SP16: -
SP17: -

ExUns: 11c · 11d · 11e ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: -
SP2: - -
SP12: -

Relevant External Links for UCKL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UCKL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UCKL1 Gene

Protein differential expression in normal tissues from HIPED for UCKL1 Gene

This gene is overexpressed in Plasma (31.0), Monocytes (13.2), and Salivary gland (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UCKL1 Gene

Protein tissue co-expression partners for UCKL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UCKL1 Gene:


SOURCE GeneReport for Unigene cluster for UCKL1 Gene:


mRNA Expression by UniProt/SwissProt for UCKL1 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for UCKL1 Gene

  • Kidney(4.3)
  • Spleen(4.3)
  • Heart(4.2)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with UCKL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UCKL1 Gene

Orthologs for UCKL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCKL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 94 (a)
-- 35
  • 88 (a)
(Monodelphis domestica)
Mammalia UCKL1 35
  • 93 (a)
(Pan troglodytes)
Mammalia UCKL1 34 35
  • 91.99 (n)
(Canis familiaris)
Mammalia UCKL1 34 35
  • 88.49 (n)
(Rattus norvegicus)
Mammalia Uckl1 34
  • 87.06 (n)
(Bos Taurus)
Mammalia UCKL1 34 35
  • 86.88 (n)
(Mus musculus)
Mammalia Uckl1 34 16 35
  • 86.19 (n)
(Gallus gallus)
Aves ZNF512B 34 35
  • 82.97 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5693 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16539 34
(Danio rerio)
Actinopterygii uckl1b 34 35
  • 77.11 (n)
uckl1a 35
  • 75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1186 34
fruit fly
(Drosophila melanogaster)
Insecta l(2)k01209 35
  • 52 (a)
(Caenorhabditis elegans)
Secernentea F19B6.1 35
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URK1 35 37
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UKL5 34
  • 51.89 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
Species where no ortholog for UCKL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UCKL1 Gene

Gene Tree for UCKL1 (if available)
Gene Tree for UCKL1 (if available)

Paralogs for UCKL1 Gene

Paralogs for UCKL1 Gene

(4) SIMAP similar genes for UCKL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UCKL1: view

Variants for UCKL1 Gene

Sequence variations from dbSNP and Humsavar for UCKL1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000047260 -- 63,945,156(+) ATGCT(C/T)AGCAC intron-variant, utr-variant-5-prime
rs1000112354 -- 63,954,094(+) GGTGC(C/T)GGACT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000147204 -- 63,947,333(+) GAGAC(C/T)CCAAA intron-variant, upstream-variant-2KB
rs1000147518 -- 63,943,090(+) GACAG(C/T)GGGAT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000157374 -- 63,943,255(+) GGTCC(C/G)TGAGG intron-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UCKL1 Gene

Variant ID Type Subtype PubMed ID
esv29498 CNV gain 19812545
esv3361353 CNV duplication 20981092
esv996794 CNV insertion 20482838
nsv1160691 CNV deletion 26073780
nsv428381 CNV gain+loss 18775914
nsv469773 CNV gain 16826518
nsv509784 CNV insertion 20534489
nsv586695 CNV loss 21841781
nsv953309 CNV deletion 24416366

Variation tolerance for UCKL1 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UCKL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCKL1 Gene

Disorders for UCKL1 Gene

Relevant External Links for UCKL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UCKL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UCKL1 Gene

Publications for UCKL1 Gene

  1. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PMID: 16709802) Fortier J.M. … Kornbluth J. (J. Immunol. 2006) 3 4 22 64
  2. Downregulation of uridine-cytidine kinase like-1 decreases proliferation and enhances tumor susceptibility to lysis by apoptotic agents and natural killer cells. (PMID: 19653100) Ambrose E.C. … Kornbluth J. (Apoptosis 2009) 3 22 64
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for UCKL1 Gene

Sources for UCKL1 Gene

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