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Aliases for UCK2 Gene

Aliases for UCK2 Gene

  • Uridine-Cytidine Kinase 2 2 3
  • Testis-Specific Protein TSA903 3 4
  • Uridine Monophosphate Kinase 2 3
  • Cytidine Monophosphokinase 2 3 4
  • Uridine Monophosphokinase 2 3 4
  • EC 2.7.1.48 4 63
  • TSA903 3 6
  • UMPK 3 4
  • Uridine Kinase 3
  • UCK 2 4
  • UK 3

External Ids for UCK2 Gene

Previous Symbols for UCK2 Gene

  • UMPK

Summaries for UCK2 Gene

Entrez Gene Summary for UCK2 Gene

  • This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]

GeneCards Summary for UCK2 Gene

UCK2 (Uridine-Cytidine Kinase 2) is a Protein Coding gene. Diseases associated with UCK2 include human monocytic ehrlichiosis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and uridine kinase activity. An important paralog of this gene is UCKL1.

UniProtKB/Swiss-Prot for UCK2 Gene

  • Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine

Gene Wiki entry for UCK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCK2 Gene

Genomics for UCK2 Gene

Genomic Location for UCK2 Gene

Start:
165,827,495 bp from pter
End:
165,911,618 bp from pter
Size:
84,124 bases
Orientation:
Plus strand

Genomic View for UCK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UCK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCK2 Gene

Regulatory Elements for UCK2 Gene

Proteins for UCK2 Gene

  • Protein details for UCK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZX2-UCK2_HUMAN
    Recommended name:
    Uridine-cytidine kinase 2
    Protein Accession:
    Q9BZX2
    Secondary Accessions:
    • Q5VV91
    • Q7KZV3
    • Q92528
    • Q96KG5
    • Q9BU42

    Protein attributes for UCK2 Gene

    Size:
    261 amino acids
    Molecular mass:
    29299 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for UCK2 Gene

    Alternative splice isoforms for UCK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UCK2 Gene

Proteomics data for UCK2 Gene at MOPED

Post-translational modifications for UCK2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys33, Lys54, Lys75, Lys78, and Lys202

Other Protein References for UCK2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UCK2 Gene

Protein Domains for UCK2 Gene

Suggested Antigen Peptide Sequences for UCK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZX2

UniProtKB/Swiss-Prot:

UCK2_HUMAN
Family:
  • Belongs to the uridine kinase family.:
    • Q9BZX2
genes like me logo Genes that share domains with UCK2: view

No data available for Gene Families for UCK2 Gene

Function for UCK2 Gene

Molecular function for UCK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + uridine = ADP + UMP
UniProtKB/Swiss-Prot CatalyticActivity: ATP + cytidine = ADP + CMP
UniProtKB/Swiss-Prot Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine

Enzyme Numbers (IUBMB) for UCK2 Gene

Gene Ontology (GO) - Molecular Function for UCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004140 dephospho-CoA kinase activity --
GO:0004849 uridine kinase activity IEA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
genes like me logo Genes that share ontologies with UCK2: view

Phenotypes for UCK2 Gene

GenomeRNAi human phenotypes for UCK2:
genes like me logo Genes that share phenotypes with UCK2: view

miRNA for UCK2 Gene

miRTarBase miRNAs that target UCK2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UCK2 Gene

Localization for UCK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCK2 Gene COMPARTMENTS Subcellular localization image for UCK2 gene
Compartment Confidence
cytosol 4
cytoskeleton 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with UCK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UCK2 Gene

Pathways for UCK2 Gene

genes like me logo Genes that share pathways with UCK2: view

Pathways by source for UCK2 Gene

UniProtKB/Swiss-Prot Q9BZX2-UCK2_HUMAN

  • Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
  • Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1

Gene Ontology (GO) - Biological Process for UCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0006238 CMP salvage IEA --
GO:0007631 feeding behavior IEA --
GO:0008152 metabolic process --
GO:0015937 coenzyme A biosynthetic process --
genes like me logo Genes that share ontologies with UCK2: view

Compounds for UCK2 Gene

(20) HMDB Compounds for UCK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Cytidine
  • 1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine
65-46-3
Cytidine monophosphate
  • 5'-CMP
63-37-6
dADP
  • 2'-deoxyadenosine-5'-diphosphate
2793-06-8

(6) Drugbank Compounds for UCK2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine-5'-Diphosphate
20398-34-9 target
Citric Acid
77-92-9 target
Cytidine
target
Cytidine-5'-Monophosphate
84-52-6 target
Cytidine-5'-Triphosphate
65-47-4 target

(16) Novoseek inferred chemical compound relationships for UCK2 Gene

Compound -log(P) Hits PubMed IDs
uridine 92.5 46
ecyd 89.4 1
ribonucleoside 79.9 1
orotic acid 78.8 5
cytidine 77.2 4
genes like me logo Genes that share compounds with UCK2: view

Transcripts for UCK2 Gene

Unigene Clusters for UCK2 Gene

Uridine-cytidine kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3:
SP4: - -
SP5:

Relevant External Links for UCK2 Gene

GeneLoc Exon Structure for
UCK2
ECgene alternative splicing isoforms for
UCK2

Expression for UCK2 Gene

mRNA expression in normal human tissues for UCK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UCK2 Gene

SOURCE GeneReport for Unigene cluster for UCK2 Gene Hs.458360

mRNA Expression by UniProt/SwissProt for UCK2 Gene

Q9BZX2-UCK2_HUMAN
Tissue specificity: According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific.
genes like me logo Genes that share expressions with UCK2: view

No data available for mRNA differential expression in normal tissues for UCK2 Gene

Orthologs for UCK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UCK2 35
  • 99.87 (n)
  • 100 (a)
UCK2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UCK2 35
  • 94 (n)
  • 98.47 (a)
UCK2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCK2 35
  • 93.16 (n)
  • 96.51 (a)
UCK2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uck2 35
  • 90.29 (n)
  • 98.08 (a)
Uck2 16
Uck2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UCK2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UCK2 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uck2 35
  • 86.59 (n)
  • 92.72 (a)
chicken
(Gallus gallus)
Aves UCK2 35
  • 83.14 (n)
  • 92.72 (a)
UCK2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UCK2 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13227 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7436 35
uck2 35
  • 75.77 (n)
  • 85.77 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
uck2a 35
  • 74.65 (n)
  • 85.33 (a)
uck2a 36
  • 84 (a)
OneToMany
uck2b 36
  • 79 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003874 35
  • 62.68 (n)
  • 64.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6364 35
  • 63.66 (n)
  • 65.67 (a)
CG6364 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0001.4 36
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAS2 38
URK1 36
  • 19 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.11296 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6934 36
  • 55 (a)
OneToMany
Species with no ortholog for UCK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UCK2 Gene

ENSEMBL:
Gene Tree for UCK2 (if available)
TreeFam:
Gene Tree for UCK2 (if available)

Paralogs for UCK2 Gene

Paralogs for UCK2 Gene

Selected SIMAP similar genes for UCK2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UCK2: view

Variants for UCK2 Gene

Sequence variations from dbSNP and Humsavar for UCK2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs477033 -- 165,890,393(+) TGTAT(C/G)TGTAT intron-variant
rs480050 -- 165,909,825(-) AGCAC(A/G)GCCCA utr-variant-3-prime
rs480813 -- 165,909,783(-) AGGAT(A/G)CTAAC utr-variant-3-prime
rs506813 -- 165,909,261(-) GGCTC(A/G)GGACT utr-variant-3-prime
rs509515 -- 165,900,463(-) ATCCT(A/G)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UCK2 Gene

Variant ID Type Subtype PubMed ID
nsv517792 CNV Loss 19592680
nsv818544 CNV Gain 17921354
nsv437246 CNV Loss 16327808
esv2719117 CNV Deletion 23290073
esv2719128 CNV Deletion 23290073
esv2719140 CNV Deletion 23290073
esv270231 CNV Insertion 20981092
esv272593 CNV Insertion 20981092

Relevant External Links for UCK2 Gene

HapMap Linkage Disequilibrium report
UCK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCK2 Gene

Disorders for UCK2 Gene

(1) University of Copenhagen DISEASES for UCK2 Gene

(3) Novoseek inferred disease relationships for UCK2 Gene

Disease -log(P) Hits PubMed IDs
solid tumor 14.3 1
tumors 3.79 7
cancer 0 4

Relevant External Links for UCK2

Genetic Association Database (GAD)
UCK2
Human Genome Epidemiology (HuGE) Navigator
UCK2
genes like me logo Genes that share disorders with UCK2: view

No data available for UniProtKB/Swiss-Prot for UCK2 Gene

Publications for UCK2 Gene

  1. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. (PMID: 11306702) Van Rompay A.R. … Karlsson A. (Mol. Pharmacol. 2001) 3 4 23
  2. Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase. (PMID: 12199906) Kashuba E. … Szekely L. (BMC Cell Biol. 2002) 3 23
  3. Crystallization and preliminary X-ray analysis of human uridine-cytidine kinase 2. (PMID: 12876357) Suzuki N.N. … Inagaki F. (Acta Crystallogr. D Biol. Crystallogr. 2003) 3 23
  4. A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides. (PMID: 15280220) Murata D. … Sasaki T. (Drug Metab. Dispos. 2004) 3 23
  5. Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative. (PMID: 15735337) Appleby T.C. … Yao N. (Acta Crystallogr. D 2005) 4 23

Products for UCK2 Gene

  • Addgene plasmids for UCK2

Sources for UCK2 Gene

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