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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UCK2 Gene

protein-coding   GIFtS: 65
GCID: GC01P165796

Uridine-Cytidine Kinase 2

(Previous name: uridine monophosphate kinase)
(Previous symbol: UMPK)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Uridine-Cytidine Kinase 21 2     EC 2.7.1.483 8
UMPK1 2 3     TSA9032 5
Uridine Monophosphate Kinase1 2     UK2
Cytidine Monophosphokinase 22 3     Uridine Kinase2
Testis-Specific Protein TSA9032 3     UCK 23
Uridine Monophosphokinase 22 3     

External Ids:    HGNC: 125621   Entrez Gene: 73712   Ensembl: ENSG000001431797   OMIM: 6093295   UniProtKB: Q9BZX23   

Export aliases for UCK2 gene to outside databases

Previous GC identifers: GC01P162528 GC01P164063 GC01P137044


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UCK2 Gene:
This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation
of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.(provided
by RefSeq, Oct 2010)

GeneCards Summary for UCK2 Gene: 
UCK2 (uridine-cytidine kinase 2) is a protein-coding gene. Diseases associated with UCK2 include bartter disease, and ehrlichiosis, and among its related super-pathways are Fluoropyrimidine Pathway, Pharmacokinetics and Metabolic pathways. GO annotations related to this gene include uridine kinase activity and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is UCKL1.

UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2
Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not
phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also
phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine,
5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine,
and N(4)-anisoylcytidine

Gene Wiki entry for UCK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UCK2 gene promoter:
         USF1   USF2   USF-1:USF-2   E2F-1   E2F   HSF2   USF-1   IRF-7A   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for UCK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q24.1   HGNC cytogenetic band: 1p32

UCK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCK2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P165796:  view genomic region     (about GC identifiers)

Start:
165,796,732 bp from pter      End:
165,880,855 bp from pter
Size:
84,124 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2 (See protein sequence)
Recommended Name: Uridine-cytidine kinase 2  
Size: 261 amino acids; 29299 Da
Subunit: Homotetramer
6 PDB 3D structures from and Proteopedia for UCK2:
1UDW (3D)        1UEI (3D)        1UEJ (3D)        1UFQ (3D)        1UJ2 (3D)        1XRJ (3D)    
Secondary accessions: Q5VV91 Q7KZV3 Q92528 Q96KG5 Q9BU42
Alternative splicing: 2 isoforms:  Q9BZX2-1   Q9BZX2-2   

Explore the universe of human proteins at neXtProt for UCK2: NX_Q9BZX2

Explore proteomics data for UCK2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BZX2

  • 4/11 DME Specific Peptides for UCK2 (Q9BZX2) (see all 11)
     LLGQNEV  RGRDLEQ  DHPDAFD  HSRKEET 

    UCK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UCK2 Protein Expression
    REFSEQ proteins: NP_036606.2  
    ENSEMBL proteins: 
     ENSP00000356853   ENSP00000361286  
    Reactome Protein details: Q9BZX2
    Human Recombinant Protein Products for UCK2: 
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    ProSpec Recombinant Protein for UCK2
    Cloud-Clone Corp. Proteins for UCK2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--
    GO:0043231intracellular membrane-bounded organelle IEA--

    UCK2 for ontologies           About GeneDecksing



    UCK2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR000764 Uridine_kinase
     IPR006083 PRK/URK

    Graphical View of Domain Structure for InterPro Entry Q9BZX2

    ProtoNet protein and cluster: Q9BZX2

    1 Blocks protein domain: IPB000764 Uridine kinase signature

    UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2
    Similarity: Belongs to the uridine kinase family


    UCK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UCK2_HUMAN, Q9BZX2
    Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not
    phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also
    phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine,
    5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine,
    and N(4)-anisoylcytidine
    Catalytic activity: ATP + uridine = ADP + UMP
    Catalytic activity: ATP + cytidine = ADP + CMP

         Enzyme Number (IUBMB): EC 2.7.1.481 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004140dephospho-CoA kinase activity ----
    GO:0004849uridine kinase activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
         
    UCK2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UCK2:
     Increased cell death HMECs cel 

    Animal Models:
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       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UCK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UCK2 
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    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate UCK2 (see all 81):
    hsa-miR-194* hsa-miR-582-3p hsa-miR-199a-3p hsa-miR-4267 hsa-miR-877* hsa-miR-409-5p hsa-miR-1244 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidUCK2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UCK2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Fluoropyrimidine Activity
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Pyrimidine metabolism
    Pyrimidine metabolism0.50
    Pyrimidine salvage reactions0.38
    4Purine metabolism
    Metabolism of nucleotides0.42
    5Purine metabolism
    Pyrimidine metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for UCK2
        Fluoropyrimidine Activity
    pyrimidine ribonucleosides salvage I

    4        Reactome Pathways for UCK2
        Metabolism of nucleotides
    Metabolism
    Pyrimidine salvage reactions
    Pyrimidine metabolism

    1 PharmGKB Pathway for UCK2
        Fluoropyrimidine Pathway, Pharmacokinetics

    3         Kegg Pathways  (Kegg details for UCK2):
        Pyrimidine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways

    UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2
    Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
    Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1


    UCK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UCK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/23 Interacting proteins for UCK2 (Q9BZX23 ENSP000003568534) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK6Q9HC983, ENSP000003627024I2D: score=1 STRING: ENSP00000362702
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    TSC22D1Q157143, ENSP000003974354I2D: score=1 STRING: ENSP00000397435
    FYNP062413I2D: score=2 
    GRB2P629933I2D: score=2 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0007631feeding behavior IEA--
    GO:0008152metabolic process ----
    GO:0015937coenzyme A biosynthetic process ----
    GO:0043097pyrimidine nucleoside salvage TAS--

    UCK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UCK2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UCK2

    10/20 HMDB Compounds for UCK2 (see all 20)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cytidine1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)65-46-3--
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--
    Inosine triphosphateinosine 5'-(tetrahydrogen triphosphate) (see all 13)132-06-9--
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--

    6 DrugBank Compounds for UCK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Citric Acid-- 77-92-9target--17139284 17016423
    Cytidine-- --target--17139284 17016423
    Cytidine-5'-Monophosphate-- 84-52-6target--17139284 17016423
    Cytidine-5'-Triphosphate-- 65-47-4target--17139284 17016423
    Uridine 5'-Triphosphate-- 63-39-8target--17139284 17016423

    10/16 Novoseek inferred chemical compound relationships for UCK2 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uridine 92.5 69 9923963 (7), 2161304 (4), 11272481 (4), 17643556 (3) (see all 29)
    ecyd 89.4 2 12903193 (1)
    ribonucleoside 79.9 1 12903193 (1)
    orotic acid 78.8 5 15913614 (1), 2167917 (1), 7872962 (1), 15508442 (1) (see all 5)
    cytidine 77.2 6 17890166 (1), 15735337 (1), 19532987 (1), 11272481 (1)
    5-fluorouridine 74.6 1 11137707 (1)
    thymidylate 71 4 8056448 (1), 16041392 (1), 2142213 (1), 15508442 (1)
    pyrimidine 68.4 5 17643556 (2), 1435081 (1)
    poly u 65.6 5 16041392 (1), 15735337 (1), 2161304 (1)
    fudr 64.8 1 2142213 (1)

    Search CenterWatch for drugs/clinical trials and news about UCK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UCK2 gene: 
    NM_012474.4  

    Unigene Cluster for UCK2:

    Uridine-cytidine kinase 2
    Hs.458360  [show with all ESTs]
    Unigene Representative Sequence: NM_012474
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367879 ENST00000462329 ENST00000464197 ENST00000469256 ENST00000470820
    ENST00000463772 ENST00000479872(uc001gdp.3 uc010plb.2) ENST00000475333
    ENST00000372212
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AB062451.1 AF236637.1 AK309739.1 BC002906.2 BT006860.1 CR456857.1 D78335.1 

    16 DOTS entries:

    DT.445046  DT.97843720  DT.213504  DT.100774693  DT.97842834  DT.121643844  DT.121359556  DT.100833732 
    DT.95076263  DT.405870  DT.92424348  DT.92424349  DT.100774692  DT.102837937  DT.121359668  DT.95076265 

    24/223 AceView cDNA sequences (see all 223):

    AW170066 BQ890639 W70171 AA325580 AA280793 AI138466 W69906 Z40872 
    F12451 BU784819 AF236637 BX400983 BM825482 AI357130 BE791049 AK055795 
    BC002906 AI497650 AI469927 AA535539 N57458 CR608443 BP355275 F05106 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for UCK2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                          -     -     -                                 
    SP2:                          -     -     -           -                     
    SP3:                                                                        
    SP4:                                -     -                                 
    SP5:                                                                        


    ECgene alternative splicing isoforms for UCK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UCK2 expression in normal human tissues (normalized intensities)      UCK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATGAAAT
    UCK2 Expression
    About this image


    UCK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             brain/midbrain   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mandibular Condyle
             skeleton/cranium   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See UCK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UCK2

    SOURCE GeneReport for Unigene cluster: Hs.458360

    UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2
    Tissue specificity: According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UCK2 gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uck21 , 5 uridine-cytidine kinase 21, 5 90.29(n)1
    98.08(a)1
      1 (74.61 cM)5
    809141  NM_030724.31  NP_109649.11 
     1672260835 
    chicken
    (Gallus gallus)
    Aves UCK21 uridine-cytidine kinase 2 83.14(n)
    92.72(a)
      424406  NM_001160071.1  NP_001153543.1 
    lizard
    (Anolis carolinensis)
    Reptilia UCK26
    Uncharacterized protein
    93(a)
    1 ↔ 1
    4(73841376-73859413)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.132272 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_036606.2 (H.sapiens) uridine monophosphate kinase; uridine-cytidine kinase 2; uridine kinase; nucleoside-phosphate kinase; NMP-kinase [Homo sapiens] less 79.45(n)    CA987247.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054665.12   -- 79.69(n)   335218  BC054665.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63646
    --
    49(a)
    1 → many
    3R(20115897-20119093)
    worm
    (Caenorhabditis elegans)
    Secernentea B0001.46
    Probable uridine-cytidine kinase
    42(a)
    1 → many
    IV(12135080-12137349)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DAS2(YDR020C)4 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases less   --   4(486444-485746) 851583  NP_010303.1 
    rice
    (Oryza sativa)
    Liliopsida AK103877.12   -- 76.47(n)    AK103877.1 


    ENSEMBL Gene Tree for UCK2 (if available)
    TreeFam Gene Tree for UCK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UCK2 gene
    UCKL12  UCK12  
    2 SIMAP similar genes for UCK2 using alignment to 2 protein entries:     UCK2_HUMAN (see all proteins):
    UCK1    UCKL1

    UCK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1758 SNPs in UCK2 are shown (see all 1758)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134293911,2
    C,F--165794761(+) TCCTCG/CTGCCT 1 -- us2k12Minor allele frequency- C:0.50CSA 4
    rs1404361161,2
    --165794844(+) TGGGGG/TTCTCA 1 -- us2k10--------
    rs1922252141,2
    --165794873(+) TCTCAA/GACTCC 1 -- us2k10--------
    rs1452258031,2
    C--165794934(+) GGCATA/GAGCCA 1 -- us2k10--------
    rs1479723791,2
    --165794950(+) CTGGCC/TTTTGG 1 -- us2k10--------
    rs1416417331,2
    --165794979(+) CTCTTC/TTCCTT 1 -- us2k10--------
    rs1501025591,2
    --165795003(+) CCCCAC/TGCTAA 1 -- us2k10--------
    rs1384719451,2
    C--165795134(+) AGGACC/TACCTA 1 -- us2k10--------
    rs1439870451,2
    C--165795160(+) ATAGCG/TATTTG 1 -- us2k10--------
    rs741189071,2
    C,F--165795234(+) TCTCCC/TCATCT 1 -- us2k13Minor allele frequency- T:0.05WA 122

    HapMap Linkage Disequilibrium report for UCK2 (165796732 - 165880855 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for UCK2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719140CNV Deletion23290073
    esv2719128CNV Deletion23290073
    esv2719117CNV Deletion23290073
    esv270231CNV Insertion20981092
    esv272593CNV Insertion20981092
    nsv437246CNV Loss16327808
    nsv517792CNV Loss19592680
    nsv818544CNV Gain17921354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609329    OMIM disorders: --

    16 diseases for UCK2:    About MalaCards
    bartter disease    ehrlichiosis    burkitt's lymphoma    fibrosarcoma
    essential hypertension    acute lymphoblastic leukemia    lymphoblastic leukemia    hypertension
    pneumonia    t-cell leukemia    hepatitis c    alcoholism
    colon cancer    leukemia    hepatocellular carcinoma    hepatitis

    1 disease from the University of Copenhagen DISEASES database for UCK2:
    Human monocytic ehrlichiosis

    UCK2 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for UCK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    solid tumor 14.3 1 2167917 (1)
    tumors 3.79 8 12149149 (2), 15280220 (1), 19837748 (1), 19653100 (1) (see all 6)
    cancer 0 6 12149149 (2), 19532987 (1), 12876357 (1)

    Genetic Association Database (GAD): UCK2
    Human Genome Epidemiology (HuGE) Navigator: UCK2 (2 documents)

    Export disorders for UCK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UCK2 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with UCK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. (PubMed id 11306702)1, 2, 9 Van Rompay A.R.... Karlsson A. (2001)
    2. A genome-wide association study of testicular germ ce ll tumor. (PubMed id 19483681)1, 4 Rapley E.A....Deloukas P. (2009)
    3. Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (2009)
    4. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (2009)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase. (PubMed id 15130468)1, 2 Suzuki N.N....Inagaki F. (2004)
    8. Cloning and expression of uridine/cytidine kinase cDNA from human fibrosarcoma cells. (PubMed id 11494055)1, 2 Koizumi K....Fukushima M. (2001)
    9. Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. (PubMed id 8812458)1, 2 Ozaki K.... Nakamura Y. (1996)
    10. Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative. (PubMed id 15735337)2, 9 Appleby T.C.... Yao N. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7371 HGNC: 12562 AceView: UCK2 Ensembl:ENSG00000143179 euGenes: HUgn7371
    ECgene: UCK2 Kegg: 7371 H-InvDB: UCK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UCK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UCK2 gene:
    Search GeneIP for patents involving UCK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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