Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UCK2 Gene

protein-coding   GIFtS: 66
GCID: GC01P165796

Uridine-Cytidine Kinase 2

(Previous name: uridine monophosphate kinase)
(Previous symbol: UMPK)
  See UCK2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Uridine-Cytidine Kinase 21 2     EC 2.7.1.483 8
UMPK1 2 3     TSA9032 5
Uridine Monophosphate Kinase1 2     UK2
Cytidine Monophosphokinase 22 3     Uridine Kinase2
Testis-Specific Protein TSA9032 3     UCK 23
Uridine Monophosphokinase 22 3     

External Ids:    HGNC: 125621   Entrez Gene: 73712   Ensembl: ENSG000001431797   OMIM: 6093295   UniProtKB: Q9BZX23   

Export aliases for UCK2 gene to outside databases

Previous GC identifers: GC01P162528 GC01P164063 GC01P137044


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UCK2 Gene:
This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation
of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.(provided
by RefSeq, Oct 2010)

GeneCards Summary for UCK2 Gene:
UCK2 (uridine-cytidine kinase 2) is a protein-coding gene. Diseases associated with UCK2 include human monocytic ehrlichiosis. GO annotations related to this gene include uridine kinase activity and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is UCKL1.

UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2
Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not
phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also
phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine,
5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine,
and N(4)-anisoylcytidine

Gene Wiki entry for UCK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the UCK2 gene promoter:
         USF1   USF2   USF-1:USF-2   E2F-1   E2F   HSF2   USF-1   IRF-7A   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCK2 promoter sequence
   Search Chromatin IP Primers for UCK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UCK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q24.1   HGNC cytogenetic band: 1p32

UCK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCK2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P165796:  view genomic region     (about GC identifiers)

Start:
165,796,732 bp from pter      End:
165,880,855 bp from pter
Size:
84,124 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2 (See protein sequence)
Recommended Name: Uridine-cytidine kinase 2  
Size: 261 amino acids; 29299 Da
Subunit: Homotetramer
6 PDB 3D structures from and Proteopedia for UCK2:
1UDW (3D)        1UEI (3D)        1UEJ (3D)        1UFQ (3D)        1UJ2 (3D)        1XRJ (3D)    
Secondary accessions: Q5VV91 Q7KZV3 Q92528 Q96KG5 Q9BU42
Alternative splicing: 2 isoforms:  Q9BZX2-1   Q9BZX2-2   

Explore the universe of human proteins at neXtProt for UCK2: NX_Q9BZX2

Explore proteomics data for UCK2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys33, Lys54, Lys75, Lys78, Lys202
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UCK2 (Q9BZX2) (see all 11)
     LLGQNEV  RGRDLEQ  DHPDAFD  HSRKEET 


    See UCK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036606.2  
    ENSEMBL proteins: 
     ENSP00000356853   ENSP00000476692   ENSP00000476327   ENSP00000361286  
    Reactome Protein details: Q9BZX2

    UCK2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UCK2
    OriGene Protein Over-expression Lysate for UCK2
    OriGene MassSpec for UCK2
    OriGene Custom Protein Services for UCK2
    GenScript Custom Purified and Recombinant Proteins Services for UCK2
    Novus Biologicals UCK2 Proteins
    Novus Biologicals UCK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for UCK2
    Cloud-Clone Corp. Proteins for UCK2

     
    Search eBioscience for Proteins for UCK2 

     
    antibodies-online proteins for UCK2 (11 products) 

     
    antibodies-online peptides for UCK2

    UCK2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UCK2
    Novus Biologicals UCK2 Antibodies
    Abcam antibodies for UCK2
    Cloud-Clone Corp. Antibodies for UCK2
    ThermoFisher Antibodies for UCK2
    antibodies-online antibodies for UCK2 (28 products) 

    UCK2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UCK2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UCK2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UCK2
    Cloud-Clone Corp. CLIAs for UCK2
    Search eBioscience for ELISAs for UCK2 
    antibodies-online kits for UCK2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR000764 Uridine_kinase
     IPR027417 P-loop_NTPase
     IPR006083 PRK/URK

    Graphical View of Domain Structure for InterPro Entry Q9BZX2

    ProtoNet protein and cluster: Q9BZX2

    1 Blocks protein domain: IPB000764 Uridine kinase signature

    UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2
    Similarity: Belongs to the uridine kinase family


    Find genes that share domains with UCK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UCK2_HUMAN, Q9BZX2
    Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not
    phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also
    phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine,
    5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine,
    and N(4)-anisoylcytidine
    Catalytic activity: ATP + uridine = ADP + UMP
    Catalytic activity: ATP + cytidine = ADP + CMP

         Enzyme Number (IUBMB): EC 2.7.1.481 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004140dephospho-CoA kinase activity ----
    GO:0004849uridine kinase activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
         
    Find genes that share ontologies with UCK2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UCK2:
     Increased cell death HMECs cel 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for UCK2

    miRNA
    Products:
        
    miRTarBase miRNAs that target UCK2:
    hsa-mir-34a-5p (MIRT025567), hsa-let-7b-5p (MIRT032462), hsa-mir-361-5p (MIRT044088)

    Block miRNA regulation of human, mouse, rat UCK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UCK2 (see all 81):
    hsa-miR-194* hsa-miR-582-3p hsa-miR-199a-3p hsa-miR-4267 hsa-miR-877* hsa-miR-409-5p hsa-miR-1244 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidUCK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UCK2
    Predesigned siRNA for gene silencing in human, mouse, rat UCK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UCK2

    Clone
    Products:
         
    OriGene clones in human, mouse for UCK2 (see all 7)
    OriGene ORF clones in mouse, rat for UCK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UCK2 (NM_012474)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCK2
    Addgene plasmids for UCK2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UCK2
    Browse ESI BIO Cell Lines and PureStem Progenitors for UCK2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--
    GO:0043231intracellular membrane-bounded organelle IEA--

    Find genes that share ontologies with UCK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for UCK2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Pyrimidine metabolism0.33
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    Pyrimidine salvage reactions0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Purine metabolism (REACTOME)
    Metabolism of nucleotides0.42
    4Purine metabolism (KEGG)
    Pyrimidine metabolism0.38
    5Glucuronidation
    Drug metabolism - other enzymes0.36


    Find genes that share SuperPaths with UCK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for UCK2
        Fluoropyrimidine Activity
    pyrimidine ribonucleosides salvage I

    1 Reactome Pathway for UCK2
        Pyrimidine salvage reactions

    1 PharmGKB Pathway for UCK2
        Fluoropyrimidine Pathway, Pharmacokinetics

    3 Kegg Pathways  (Kegg details for UCK2):
        Pyrimidine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways

    UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2
    Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
    Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1

        Pathway & Disease-focused RT2 Profiler PCR Array including UCK2: 

              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UCK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UCK2 (Q9BZX23 ENSP000003568534) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK6Q9HC983, ENSP000003627024I2D: score=1 STRING: ENSP00000362702
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    TSC22D1Q157143, ENSP000003974354I2D: score=1 STRING: ENSP00000397435
    FYNP062413I2D: score=2 
    GRB2P629933I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0007631feeding behavior IEA--
    GO:0008152metabolic process ----
    GO:0015937coenzyme A biosynthetic process ----
    GO:0043097pyrimidine nucleoside salvage TAS--

    Find genes that share ontologies with UCK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UCK2

    Selected HMDB Compounds for UCK2 (see all 20)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cytidine1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)65-46-3--
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--
    Inosine triphosphateinosine 5'-(tetrahydrogen triphosphate) (see all 13)132-06-9--
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--

    6 DrugBank Compounds for UCK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Citric Acid-- 77-92-9target--17139284 17016423
    Cytidine-- --target--17139284 17016423
    Cytidine-5'-Monophosphate-- 84-52-6target--17139284 17016423
    Cytidine-5'-Triphosphate-- 65-47-4target--17139284 17016423
    Uridine 5'-Triphosphate-- 63-39-8target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for UCK2 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uridine 92.5 69 9923963 (7), 2161304 (4), 11272481 (4), 17643556 (3) (see all 29)
    ecyd 89.4 2 12903193 (1)
    ribonucleoside 79.9 1 12903193 (1)
    orotic acid 78.8 5 15913614 (1), 2167917 (1), 7872962 (1), 15508442 (1) (see all 5)
    cytidine 77.2 6 17890166 (1), 15735337 (1), 19532987 (1), 11272481 (1)
    5-fluorouridine 74.6 1 11137707 (1)
    thymidylate 71 4 8056448 (1), 16041392 (1), 2142213 (1), 15508442 (1)
    pyrimidine 68.4 5 17643556 (2), 1435081 (1)
    poly u 65.6 5 16041392 (1), 15735337 (1), 2161304 (1)
    fudr 64.8 1 2142213 (1)



    Find genes that share compounds with UCK2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UCK2 gene: 
    NM_012474.4  

    Unigene Cluster for UCK2:

    Uridine-cytidine kinase 2
    Hs.458360  [show with all ESTs]
    Unigene Representative Sequence: NM_012474
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367879 ENST00000462329 ENST00000464197 ENST00000469256 ENST00000470820
    ENST00000463772 ENST00000479872(uc001gdp.3 uc010plb.2) ENST00000475333
    ENST00000372212
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UCK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UCK2 (see all 81):
    hsa-miR-194* hsa-miR-582-3p hsa-miR-199a-3p hsa-miR-4267 hsa-miR-877* hsa-miR-409-5p hsa-miR-1244 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidUCK2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UCK2
    Predesigned siRNA for gene silencing in human, mouse, rat UCK2
    Clone
    Products:
         
    OriGene clones in human, mouse for UCK2 (see all 7)
    OriGene ORF clones in mouse, rat for UCK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UCK2 (NM_012474)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCK2
    Addgene plasmids for UCK2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UCK2
    OriGene qSTAR qPCR primer pairs in human, mouse for UCK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UCK2
      QuantiTect SYBR Green Assays in human, mouse, rat UCK2
      QuantiFast Probe-based Assays in human, mouse, rat UCK2

    Additional mRNA sequence: 

    AB062451.1 AF236637.1 AK309739.1 BC002906.2 BT006860.1 CR456857.1 D78335.1 

    16 DOTS entries:

    DT.445046  DT.97843720  DT.213504  DT.100774693  DT.97842834  DT.121643844  DT.121359556  DT.100833732 
    DT.95076263  DT.405870  DT.92424348  DT.92424349  DT.100774692  DT.102837937  DT.121359668  DT.95076265 

    Selected AceView cDNA sequences (see all 223):

    AL698758 BM904054 Z45142 BU179959 AW516114 BM904895 AI357130 AF236637 
    BX400983 Z40872 W70171 AA325580 AA280793 BM825482 W69906 F12451 
    BU158939 BQ890639 T48534 AI138466 NM_012474 AW170066 AI677708 BU159237 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for UCK2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                          -     -     -                                 
    SP2:                          -     -     -           -                     
    SP3:                                                                        
    SP4:                                -     -                                 
    SP5:                                                                        


    ECgene alternative splicing isoforms for UCK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UCK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATGAAAT
    UCK2 Expression
    About this image


    UCK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mandibular Condyle
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Kidney (Urinary System)
             Metanephros
    UCK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UCK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458360

    UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2
    Tissue specificity: According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific

        Pathway & Disease-focused RT2 Profiler PCR Array including UCK2: 
              Cardiotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UCK2
    OriGene qSTAR qPCR primer pairs in human, mouse for UCK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UCK2
    QuantiTect SYBR Green Assays in human, mouse, rat UCK2
    QuantiFast Probe-based Assays in human, mouse, rat UCK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UCK2 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uck21 , 5 uridine-cytidine kinase 21, 5 90.29(n)1
    98.08(a)1
      1 (74.61 cM)5
    809141  NM_030724.31  NP_109649.11 
     1672260835 
    chicken
    (Gallus gallus)
    Aves UCK21 uridine-cytidine kinase 2 83.14(n)
    92.72(a)
      424406  NM_001160071.2  NP_001153543.1 
    lizard
    (Anolis carolinensis)
    Reptilia UCK26
    uridine-cytidine kinase 2
    93(a)
    1 ↔ 1
    4(73841376-73859413)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.132272 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_036606.2 (H.sapiens) uridine monophosphate kinase; uridine-cytidine kinase 2; uridine kinase; nucleoside-phosphate kinase; NMP-kinase [Homo sapiens] less 79.45(n)    CA987247.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054665.12   -- 79.69(n)   335218  BC054665.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63641 CG6364 63.66(n)
    65.67(a)
      42894  NM_001260352.2  NP_001247281.1 
    worm
    (Caenorhabditis elegans)
    Secernentea B0001.46
    Protein B0001.4 (B0001.4) mRNA, complete cds
    44(a)
    1 → many
    IV(12135080-12137349) WBGene00007089
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DAS2(YDR020C)4 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases less   --   4(486444-485746) 851583  NP_010303.1 
    rice
    (Oryza sativa)
    Liliopsida AK103877.12   -- 76.47(n)    AK103877.1 


    ENSEMBL Gene Tree for UCK2 (if available)
    TreeFam Gene Tree for UCK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UCK2 gene
    UCKL12  UCK12  
    2 SIMAP similar genes for UCK2 using alignment to 2 protein entries:     UCK2_HUMAN (see all proteins):
    UCK1    UCKL1

    Find genes that share paralogs with UCK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UCK2 (see all 1758)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134293911,2
    C,F--165794761(+) TCCTCG/CTGCCT 1 -- us2k12Minor allele frequency- C:0.50CSA 4
    rs1404361161,2
    --165794844(+) TGGGGG/TTCTCA 1 -- us2k10--------
    rs1922252141,2
    --165794873(+) TCTCAA/GACTCC 1 -- us2k10--------
    rs1452258031,2
    C--165794934(+) GGCATA/GAGCCA 1 -- us2k10--------
    rs1479723791,2
    --165794950(+) CTGGCC/TTTTGG 1 -- us2k10--------
    rs1416417331,2
    --165794979(+) CTCTTC/TTCCTT 1 -- us2k10--------
    rs1501025591,2
    --165795003(+) CCCCAC/TGCTAA 1 -- us2k10--------
    rs1384719451,2
    C--165795134(+) AGGACC/TACCTA 1 -- us2k10--------
    rs1439870451,2
    C--165795160(+) ATAGCG/TATTTG 1 -- us2k10--------
    rs741189071,2
    C,F--165795234(+) TCTCCC/TCATCT 1 -- us2k13Minor allele frequency- T:0.05WA 122

    HapMap Linkage Disequilibrium report for UCK2 (165796732 - 165880855 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for UCK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719140CNV Deletion23290073
    esv2719128CNV Deletion23290073
    esv2719117CNV Deletion23290073
    esv270231CNV Insertion20981092
    esv272593CNV Insertion20981092
    nsv437246CNV Loss16327808
    nsv517792CNV Loss19592680
    nsv818544CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UCK2
    DNA2.0 Custom Variant and Variant Library Synthesis for UCK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609329    OMIM disorders: --

    1 disease for UCK2:    
    About MalaCards
    human monocytic ehrlichiosis

    1 disease from the University of Copenhagen DISEASES database for UCK2:
    Human monocytic ehrlichiosis

    Find genes that share disorders with UCK2           About GenesLikeMe

    3 Novoseek inferred disease relationships for UCK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    solid tumor 14.3 1 2167917 (1)
    tumors 3.79 8 12149149 (2), 15280220 (1), 19837748 (1), 19653100 (1) (see all 6)
    cancer 0 6 12149149 (2), 19532987 (1), 12876357 (1)

    Genetic Association Database (GAD): UCK2
    Human Genome Epidemiology (HuGE) Navigator: UCK2 (2 documents)

    Export disorders for UCK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UCK2 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with UCK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. (PubMed id 11306702)1, 2, 9 Van Rompay A.R.... Karlsson A. (Mol. Pharmacol. 2001)
    2. A genome-wide association study of testicular germ cell tumor. (PubMed id 19483681)1, 4 Rapley E.A....Stratton M.R. (Nat. Genet. 2009)
    3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    4. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (Hum. Mol. Genet. 2009)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase. (PubMed id 15130468)1, 2 Suzuki N.N.... Inagaki F. (Structure 2004)
    8. Cloning and expression of uridine/cytidine kinase cDNA from human fibrosarcoma cells. (PubMed id 11494055)1, 2 Koizumi K....Fukushima M. (Int. J. Mol. Med. 2001)
    9. Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. (PubMed id 8812458)1, 2 Ozaki K.... Nakamura Y. (Genomics 1996)
    10. Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative. (PubMed id 15735337)2, 9 Appleby T.C.... Yao N. (Acta Crystallogr. D 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7371 HGNC: 12562 AceView: UCK2 Ensembl:ENSG00000143179 euGenes: HUgn7371
    ECgene: UCK2 Kegg: 7371 H-InvDB: UCK2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UCK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UCK2 gene:
    Search GeneIP for patents involving UCK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for UCK2  
     OriGene qPCR primer pairs and template standards for UCK2   OriGene Protein Over-expression Lysate for UCK2  
     OriGene MassSpec for UCK2   OriGene clones in human, mouse for UCK2  
     OriGene qSTAR qPCR primer pairs in human, mouse for UCK2   OriGene Purified Protein for UCK2  
     OriGene ORF clones in mouse, rat for UCK2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UCK2   OriGene Custom Protein Services for UCK2  

     
     
     Block miRNA regulation of human, mouse, rat UCK2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UCK2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UCK2 Predesigned siRNA for gene silencing in human, mouse, rat UCK2
     QuantiFast Probe-based Assays in human, mouse, rat UCK2 QuantiTect SYBR Green Assays in human, mouse, rat UCK2
     PCR Arrays including human, mouse, rat UCK2 Search Chromatin IP Primers for UCK2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UCK2  GeneGlobe Interaction Network for UCK2
     Regulatory tfbs in UCK2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UCK2 GenScript cDNA clones with any tag delivered in your preferred vector for UCK2
     GenScript Custom Assay Services for UCK2 GenScript Custom overexpressing Cell Line Services for UCK2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UCK2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UCK2 antibodies
     UCK2 proteins
     UCK2 lysates
     Antibodies for UCK2
     See all of Abcam's Antibodies, Kits and Proteins for UCK2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for UCK2
     Proteins for UCK2
     Antibodies for UCK2
     ELISAs for UCK2
     CLIAs for UCK2



     Browse ESI BIO Cell Lines and PureStem Progenitors for UCK2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCK2
     SwitchGear 3'UTR luciferase reporter plasmids for UCK2
     SwitchGear Promoter luciferase reporter plasmids for UCK2
     ThermoFisher Antibodies for UCK2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCK2
     Browse compounds at ApexBio
     Addgene plasmids for UCK2
      Search eBioscience for proteins for UCK2
      Search eBioscience for elisas for UCK2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for UCK2
     antibodies-online antibodies for UCK2 (28 products)
     antibodies-online kits for UCK2 (6 products)
     antibodies-online peptides for UCK2
     antibodies-online proteins for UCK2 (11 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UCK2 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4