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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UCK2 Gene

protein-coding GIFtS: 65
GCID: GC01P165796

uridine-cytidine kinase 2

(Previous name: uridine monophosphate kinase )
(Previous symbol: UMPK)

Explore 17 diseases affiliated with
UCK2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Uridine-Cytidine Kinase 2¹ ²		EC 2.7.1.48³ ⁸
UMPK¹ ² ³		TSA903² ⁵
Uridine Monophosphate Kinase¹ ²		UK²
Cytidine Monophosphokinase 2² ³		Uridine Kinase²
Testis-Specific Protein TSA903² ³		UCK 2³
Uridine Monophosphokinase 2² ³

External Ids:	HGNC: 12562¹	Entrez Gene: 7371²	Ensembl: ENSG00000143179⁷	OMIM: 609329⁵	UniProtKB: Q9BZX2³

Export aliases for UCK2 gene to outside databases

Previous GC identifers: GC01P162528 GC01P164063 GC01P137044

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UCK2:

This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of

uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.(provided by

RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2

Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not

phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also

phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine,

5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and

N(4)-anisoylcytidine

Gene Wiki entry for UCK2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UCK2 gene promoter:
USF1 USF2 USF-1:USF-2 E2F-1 E2F HSF2 USF-1 IRF-7A FOXO1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UCK2 promoter sequence

Search SABiosciences Chromatin IP Primers for UCK2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCK2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23 Ensembl cytogenetic band: 1q24.1 HGNC cytogenetic band: 1p32

UCK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCK2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P165796: view genomic region (about GC identifiers)

Start:	165,796,768 bp from pter	End:	165,880,855 bp from pter
Size:	84,088 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2 (See protein sequence)

Recommended Name: Uridine-cytidine kinase 2

Size: 261 amino acids; 29299 Da

Subunit: Homotetramer

6 PDB 3D structures from and Proteopedia for UCK2:

1UDW (3D)

1UEI (3D)

1UEJ (3D)

1UFQ (3D)

1UJ2 (3D)

1XRJ (3D)

Secondary accessions: Q5VV91 Q7KZV3 Q92528 Q96KG5 Q9BU42

Alternative splicing: 2 isoforms: Q9BZX2-1 Q9BZX2-2

Explore the universe of human proteins at neXtProt for UCK2: NX_Q9BZX2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BZX2

4/11 DME Specific Peptides for UCK2 (Q9BZX2) (see all 11)

LLGQNEV

RGRDLEQ

DHPDAFD

HSRKEET

UCK2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036606.2

ENSEMBL proteins:

ENSP00000356853 ENSP00000361286

Reactome Protein details: Q9BZX2
Human Recombinant Protein Products for UCK2:

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Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005792	microsome	--	--
GO:0005829	cytosol	TAS	--
GO:0043231	intracellular membrane-bounded organelle	IEA	--

UCK2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UCK2 for domains About GeneDecksing

2 InterPro domains/families:

IPR000764 Uridine_kinase

IPR006083 PRK/URK

Graphical View of Domain Structure for InterPro Entry Q9BZX2

ProtoNet protein and cluster: Q9BZX2

1 Blocks protein family: IPB000764 Uridine kinase signature

UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2

Similarity: Belongs to the uridine kinase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: UCK2_HUMAN, Q9BZX2

Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not

phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also

phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine,

5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and

N(4)-anisoylcytidine

Catalytic activity: ATP + uridine = ADP + UMP

Catalytic activity: ATP + cytidine = ADP + CMP

Enzyme Number (IUBMB): EC 2.7.1.48¹ ²

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004849	uridine kinase activity	IEA	--
GO:0005515	protein binding	--	--
GO:0005524	ATP binding	IEA	--
GO:0016301	kinase activity	--	--
GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA	--

UCK2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for UCK2:

Increased cell death HMECs cel

Animal Models:

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		hsa-miR-194* hsa-miR-582-3p hsa-miR-199a-3p hsa-miR-4267 hsa-miR-877* hsa-miR-409-5p hsa-miR-1244 hsa-miR-149

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCK2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Pyrimidine metabolism

Pyrimidine metabolism

1.00

Pyrimidine salvage reactions

0.38

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Fluoropyrimidine Activity

Fluoropyrimidine Activity

1.00

Fluoropyrimidine Pathway, Pharmacokinetics

0.73

pyrimidine ribonucleotides interconversion

salvage pathways of pyrimidine ribonucleotides

0.45

Purine metabolism

Metabolism of nucleotides

0.42

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for UCK2

	Fluoropyrimidine Activity
	salvage pathways of pyrimidine ribonucleotides

4 Reactome Pathways for UCK2

	Metabolism of nucleotides
	Metabolism
	Pyrimidine salvage reactions
	Pyrimidine metabolism

1 PharmGKB Pathway for UCK2

Fluoropyrimidine Pathway, Pharmacokinetics

3 Kegg Pathways (Kegg details for UCK2):

	Pyrimidine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways

UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2

Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3

Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1

UCK2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for UCK2

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/23 Interacting proteins for UCK2 (Q9BZX2³ ENSP00000356853⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NEK6	Q9HC98³, ENSP00000362702⁴	I2D: score=1 STRING: ENSP00000362702
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
TSC22D1	Q15714³, ENSP00000397435⁴	I2D: score=1 STRING: ENSP00000397435
FYN	P06241³	I2D: score=2
GRB2	P62993³	I2D: score=2

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006206	pyrimidine nucleobase metabolic process	TAS	--
GO:0007631	feeding behavior	IEA	--
GO:0009165	nucleotide biosynthetic process	--	--
GO:0043097	pyrimidine nucleoside salvage	TAS	--
GO:0044206	UMP salvage	IEA	--

UCK2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

UCK2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UCK2

10/20 HMDB Compounds for UCK2 (see all 20) About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Cytidine	1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)	65-46-3	--
Cytidine monophosphate	5'-CMP (see all 14)	63-37-6	--
Deoxyuridine triphosphate	2'-Deoxyuridine-5'-triphosphorate (see all 9)	1173-82-6	--
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--
IDP	5'-IDP (see all 10)	86-04-4	--
Inosine triphosphate	inosine 5'-(tetrahydrogen triphosphate) (see all 13)	132-06-9	--
Thymidine 5'-triphosphate	2'-Deoxythymidine 5'-triphosphate (see all 13)	365-08-2	--

6 DrugBank Compounds for UCK2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Adenosine-5'-Diphosphate	--	20398-34-9	target	--	17139284 17016423
Citric Acid	--	77-92-9	target	--	17139284 17016423
Cytidine	--	--	target	--	17139284 17016423
Cytidine-5'-Monophosphate	--	84-52-6	target	--	17139284 17016423
Cytidine-5'-Triphosphate	--	65-47-4	target	--	17139284 17016423
Uridine 5'-Triphosphate	--	63-39-8	target	--	17139284 17016423

10/16 Novoseek chemical compound relationships for UCK2 gene (see all 16) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
uridine	92.5	69	9923963 (7), 2161304 (4), 11272481 (4), 17643556 (3) (see all 29)
ecyd	89.4	2	12903193 (1)
ribonucleoside	79.9	1	12903193 (1)
orotic acid	78.8	5	15913614 (1), 2167917 (1), 7872962 (1), 15508442 (1) (see all 5)
cytidine	77.2	6	17890166 (1), 15735337 (1), 19532987 (1), 11272481 (1)
5-fluorouridine	74.6	1	11137707 (1)
thymidylate	71	4	8056448 (1), 16041392 (1), 2142213 (1), 15508442 (1)
pyrimidine	68.4	5	17643556 (2), 1435081 (1)
poly u	65.6	5	16041392 (1), 15735337 (1), 2161304 (1)
fudr	64.8	1	2142213 (1)

Search CenterWatch for drugs/clinical trials and news about UCK2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UCK2 gene:

NM_012474.4

Unigene Cluster for UCK2:

Uridine-cytidine kinase 2

Hs.458360 [show with all ESTs]

Unigene Representative Sequence: NM_012474

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367879 ENST00000462329 ENST00000464197 ENST00000469256 ENST00000470820

ENST00000463772 ENST00000479872(uc001gdp.3 uc010plb.2) ENST00000475333

ENST00000372212

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Additional cDNA sequence:

AB062451.1 AF236637.1 AK309739.1 BC002906.2 BT006860.1 CR456857.1 D78335.1

16 DOTS entries:

DT.445046 DT.97843720 DT.213504 DT.100774693 DT.97842834 DT.121643844 DT.121359556 DT.100833732

DT.95076263 DT.405870 DT.92424348 DT.92424349 DT.100774692 DT.102837937 DT.121359668 DT.95076265

24/223 AceView cDNA sequences (see all 223):

N29514 BM053091 AI078820 AI357130 CR608443 BM904895 BM994462 AI497650

AF236637 BX400983 AL698758 BM459096 BM825482 AA325580 Z45142 BU784819

AW516114 BM904054 BU179959 AK055795 BU158939 BP355275 AA468735 BU161711

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for UCK2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b
SP1:									-		-		-
SP2:									-		-		-				-
SP3:
SP4:											-		-
SP5:

ECgene alternative splicing isoforms for UCK2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UCK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGATGAAAT

About this image

UCK2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Mandibular Condyle

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See UCK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UCK2

SOURCE GeneReport for Unigene cluster: Hs.458360

UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2

Tissue specificity: According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific

SABiosciences Expression via Pathway-Focused PCR Array including UCK2:

Cardiotoxicity in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCK2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for UCK2 gene from 9/32 species (see all 32) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	UCK2¹	uridine-cytidine kinase 2	83.14(n) 92.72(a)		424406 NM_001160071.1 NP_001153543.1
lizard (Anolis carolinensis)	Reptilia	UPRT⁶ UCK2⁶	--	93(a)	possible ortholog 1 ↔ 1	GL343825.1(74337-84296) 4(73841376-73857190)
African clawed frog (Xenopus laevis)	Amphibia	Xl.13227²	Xenopus laevis transcribed sequence with moderate similarity to protein refNP_036606.2 (H.sapiens) uridine monophosphate kinase; uridine-cytidine kinase 2; uridine kinase; nucleoside-phosphate kinase; NMP-kinase [Homo sapiens] less	79.45(n)		CA987247.1
zebrafish (Danio rerio)	Actinopterygii	BC054665.1²	--	79.69(n)		335218 BC054665.1
fruit fly (Drosophila melanogaster)	Insecta	CG5537⁶ CG6364⁶	--	48(a)	possible ortholog 1 ↔ many	3L(5804073-5805328) 3R(20115897-20119093)
worm (Caenorhabditis elegans)	Secernentea	B0001.4⁶	Probable uridine-cytidine kinase	42(a)	possible ortholog	IV(12135058-12137327)
thale cress (Arabidopsis thaliana)	eudicotyledons	UKL3⁶ UKL5⁶ (see all 6)	putative uracil phosphoribosyltransferase (see all 6)	22(a) 21(a) (see all 6)	many ↔ many many ↔ many (see all 6)	1(20860609-20864266) 3(10155555-10157931)
rice (Oryza sativa)	Liliopsida	AK103877.1²	--	76.47(n)		AK103877.1
E. coli (Escherichia coli)	Gamma proteobacteria	udk⁶	uridine/cytidine kinase	34(a)	possible ortholog	Chromosome(2140331-2140972)

ENSEMBL Gene Tree for UCK2 (if available)
TreeFam Gene Tree for UCK2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for UCK2 gene

UCKL1² UCK1²

2 SIMAP similar genes for UCK2 using alignment to 2 protein entries: UCK2_HUMAN (see all proteins):

UCK1 UCKL1

UCK2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113429391^1,2	F	--	165794761(+)	`TCCTCG/CTGCCT`	1	--	us2k¹		2		CSA	4
rs140436116^1,2		--	165794844(+)	`TGGGGG/TTCTCA`	1	--	us2k¹		0	--	--	--	--
rs192225214^1,2		--	165794873(+)	`TCTCAA/GACTCC`	1	--	us2k¹		0	--	--	--	--
rs145225803^1,2		--	165794934(+)	`GGCATA/GAGCCA`	1	--	us2k¹		0	--	--	--	--
rs147972379^1,2		--	165794950(+)	`CTGGCC/TTTTGG`	1	--	us2k¹		0	--	--	--	--
rs141641733^1,2		--	165794979(+)	`CTCTTC/TTCCTT`	1	--	us2k¹		0	--	--	--	--
rs150102559^1,2		--	165795003(+)	`CCCCAC/TGCTAA`	1	--	us2k¹		0	--	--	--	--
rs138471945^1,2		--	165795134(+)	`AGGACC/TACCTA`	1	--	us2k¹		0	--	--	--	--
rs143987045^1,2		--	165795160(+)	`ATAGCG/TATTTG`	1	--	us2k¹		0	--	--	--	--
rs74118907^1,2	C,F	--	165795234(+)	`TCTCCC/TCATCT`	1	--	us2k¹		3		WA	122

HapMap Linkage Disequilibrium report for UCK2 (165796768 - 165880855 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for UCK2
3 CNVs: 1341 9380 48166

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

UCK2 for disorders           About GeneDecksing

OMIM gene information: 609329    OMIM disorders: --

17 diseases for UCK2:    About MalaCards

bartter disease acute lymphoblastic leukemia lymphoblastic leukemia burkitt's lymphoma

essential hypertension hepatitis c fibrosarcoma colon carcinoma

hypertension hepatocellular carcinoma t-cell leukemia leukemia

colon cancer hepatitis pneumonia carcinoma

alcoholism

1 disease from the University of Copenhagen DISEASES database for UCK2:

Ehrlichiosis

3 Novoseek disease relationships for UCK2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
solid tumor	14.3	1	2167917 (1)
tumors	3.79	8	12149149 (2), 15280220 (1), 19837748 (1), 19653100 (1) (see all 6)
cancer	0	6	12149149 (2), 19532987 (1), 12876357 (1)

Human Genome Epidemiology (HuGE) Navigator: UCK2 (2 documents)

Export disorders for UCK2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for UCK2 gene, integrated from 9 sources (see all 66):
(articles sorted by number of sources associating them with UCK2)

Utopia: connect your pdf to the dynamic
world of online information

Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. (PubMed id 11306702)^{1, 2, 9} Van Rompay A.R.... Karlsson A. (2001)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase. (PubMed id 15130468)^{1, 2} Suzuki N.N....Inagaki F. (2004)
Cloning and expression of uridine/cytidine kinase cDNA from human fibrosarcoma cells. (PubMed id 11494055)^{1, 2} Koizumi K....Fukushima M. (2001)
Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. (PubMed id 8812458)^{1, 2} Ozaki K.... Nakamura Y. (1996)
Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative. (PubMed id 15735337)^{2, 9} Appleby T.C.... Yao N. (2005)
A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides. (PubMed id 15280220)^{1, 9} Murata D....Sasaki T. (2004)
Quantum mechanics/molecular mechanics investigation o f the mechanism of phosphate transfer in human uridine-cytidine kinase 2. (PubMed id 19532987)^{1, 9} Smith A.J....Houk K.N. (2009)
Crystallization and preliminary X-ray analysis of human uridine-cytidine kinase 2. (PubMed id 12876357)^{1, 9} Suzuki N.N....Inagaki F. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7371	HGNC: 12562	AceView: UCK2	Ensembl:ENSG00000143179	euGenes: HUgn7371
ECgene: UCK2	Kegg: 7371	H-InvDB: UCK2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for UCK2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UCK2 gene
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Patent Information for UCK2 gene:
Search GeneIP for patents involving UCK2

GeneCards and IP:
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uridine-cytidine kinase 2

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uridine-cytidine kinase 2

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