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Aliases for UCK2 Gene

Aliases for UCK2 Gene

  • Uridine-Cytidine Kinase 2 2 3
  • Testis-Specific Protein TSA903 3 4
  • Uridine Monophosphate Kinase 2 3
  • Cytidine Monophosphokinase 2 3 4
  • Uridine Monophosphokinase 2 3 4
  • EC 2.7.1.48 4 63
  • UMPK 3 4
  • Uridine Kinase 3
  • TSA903 3
  • UCK 2 4
  • UK 3

External Ids for UCK2 Gene

Previous HGNC Symbols for UCK2 Gene

  • UMPK

Previous GeneCards Identifiers for UCK2 Gene

  • GC01P162528
  • GC01P164063
  • GC01P137044

Summaries for UCK2 Gene

Entrez Gene Summary for UCK2 Gene

  • This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]

GeneCards Summary for UCK2 Gene

UCK2 (Uridine-Cytidine Kinase 2) is a Protein Coding gene. Diseases associated with UCK2 include testicular germ cell tumor. Among its related pathways are Metabolism and Purine metabolism. GO annotations related to this gene include kinase activity and dephospho-CoA kinase activity. An important paralog of this gene is UCKL1.

UniProtKB/Swiss-Prot for UCK2 Gene

  • Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine

Gene Wiki entry for UCK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCK2 Gene

Genomics for UCK2 Gene

Regulatory Elements for UCK2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UCK2 Gene

Chromosome:
1
Start:
165,827,495 bp from pter
End:
165,911,618 bp from pter
Size:
84,124 bases
Orientation:
Plus strand

Genomic View for UCK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for UCK2 Gene

Proteins for UCK2 Gene

  • Protein details for UCK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZX2-UCK2_HUMAN
    Recommended name:
    Uridine-cytidine kinase 2
    Protein Accession:
    Q9BZX2
    Secondary Accessions:
    • Q5VV91
    • Q7KZV3
    • Q92528
    • Q96KG5
    • Q9BU42

    Protein attributes for UCK2 Gene

    Size:
    261 amino acids
    Molecular mass:
    29299 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for UCK2 Gene

    Alternative splice isoforms for UCK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UCK2 Gene

Proteomics data for UCK2 Gene at MOPED

Post-translational modifications for UCK2 Gene

  • Ubiquitination at Lys 33, Lys 54, and Lys 78
  • Modification sites at PhosphoSitePlus

Other Protein References for UCK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for UCK2

Domains & Families for UCK2 Gene

Protein Domains for UCK2 Gene

Suggested Antigen Peptide Sequences for UCK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZX2

UniProtKB/Swiss-Prot:

UCK2_HUMAN :
  • Belongs to the uridine kinase family.
Family:
  • Belongs to the uridine kinase family.
genes like me logo Genes that share domains with UCK2: view

No data available for Gene Families for UCK2 Gene

Function for UCK2 Gene

Molecular function for UCK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + uridine = ADP + UMP
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + cytidine = ADP + CMP
UniProtKB/Swiss-Prot Function:
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine

Enzyme Numbers (IUBMB) for UCK2 Gene

Gene Ontology (GO) - Molecular Function for UCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004849 uridine kinase activity IBA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
GO:0019206 nucleoside kinase activity EXP --
genes like me logo Genes that share ontologies with UCK2: view
genes like me logo Genes that share phenotypes with UCK2: view

Animal Model Products

miRNA for UCK2 Gene

miRTarBase miRNAs that target UCK2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UCK2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for UCK2 Gene

Localization for UCK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCK2 Gene COMPARTMENTS Subcellular localization image for UCK2 gene
Compartment Confidence
cytosol 4

Gene Ontology (GO) - Cellular Components for UCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UCK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UCK2 Gene

Pathways & Interactions for UCK2 Gene

genes like me logo Genes that share pathways with UCK2: view

Pathways by source for UCK2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9BZX2-UCK2_HUMAN

  • Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
  • Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1

Gene Ontology (GO) - Biological Process for UCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0006238 CMP salvage IEA --
GO:0008152 metabolic process --
GO:0016310 phosphorylation IEA --
GO:0043097 pyrimidine nucleoside salvage TAS --
genes like me logo Genes that share ontologies with UCK2: view

No data available for SIGNOR curated interactions for UCK2 Gene

Drugs & Compounds for UCK2 Gene

(19) Drugs for UCK2 Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Cytidine Experimental Pharma Target 0
Cytidine triphosphate Experimental Pharma Target 0
Uridine triphosphate Experimental Pharma Target 0
5-Fluorouridine Experimental Pharma 0

(21) Additional Compounds for UCK2 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Fluorouridine monophosphate
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
63-37-6
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
genes like me logo Genes that share compounds with UCK2: view

Transcripts for UCK2 Gene

Unigene Clusters for UCK2 Gene

Uridine-cytidine kinase 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UCK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3:
SP4: - -
SP5:

Relevant External Links for UCK2 Gene

GeneLoc Exon Structure for
UCK2
ECgene alternative splicing isoforms for
UCK2

Expression for UCK2 Gene

mRNA expression in normal human tissues for UCK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UCK2 Gene

This gene is overexpressed in Bone (36.4) and Breast (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UCK2 Gene



SOURCE GeneReport for Unigene cluster for UCK2 Gene Hs.458360

mRNA Expression by UniProt/SwissProt for UCK2 Gene

Q9BZX2-UCK2_HUMAN
Tissue specificity: According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific.
genes like me logo Genes that share expression patterns with UCK2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for UCK2 Gene

Orthologs for UCK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UCK2 35
  • 94 (n)
  • 98.47 (a)
UCK2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCK2 35
  • 93.16 (n)
  • 96.51 (a)
UCK2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uck2 35
  • 90.29 (n)
  • 98.08 (a)
Uck2 16
Uck2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UCK2 35
  • 99.87 (n)
  • 100 (a)
UCK2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uck2 35
  • 86.59 (n)
  • 92.72 (a)
oppossum
(Monodelphis domestica)
Mammalia UCK2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UCK2 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves UCK2 35
  • 83.14 (n)
  • 92.72 (a)
UCK2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UCK2 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7436 35
uck2 35
  • 75.77 (n)
  • 85.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13227 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
uck2a 35
  • 74.65 (n)
  • 85.33 (a)
uck2a 36
  • 84 (a)
OneToMany
uck2b 36
  • 79 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003874 35
  • 62.68 (n)
  • 64.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6364 35
  • 63.66 (n)
  • 65.67 (a)
CG6364 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0001.4 36
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URK1 36
  • 19 (a)
OneToMany
DAS2 38
wheat
(Triticum aestivum)
Liliopsida Ta.11296 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6934 36
  • 55 (a)
OneToMany
Species with no ortholog for UCK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UCK2 Gene

ENSEMBL:
Gene Tree for UCK2 (if available)
TreeFam:
Gene Tree for UCK2 (if available)

Paralogs for UCK2 Gene

Paralogs for UCK2 Gene

(2) SIMAP similar genes for UCK2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UCK2: view

Variants for UCK2 Gene

Sequence variations from dbSNP and Humsavar for UCK2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs477033 -- 165,890,393(+) TGTAT(C/G)TGTAT intron-variant
rs480050 -- 165,909,825(-) AGCAC(A/G)GCCCA utr-variant-3-prime
rs480813 -- 165,909,783(-) AGGAT(A/G)CTAAC utr-variant-3-prime
rs506813 -- 165,909,261(-) GGCTC(A/G)GGACT utr-variant-3-prime
rs509515 -- 165,900,463(-) ATCCT(A/G)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UCK2 Gene

Variant ID Type Subtype PubMed ID
nsv517792 CNV Loss 19592680
nsv818544 CNV Gain 17921354
nsv437246 CNV Loss 16327808
esv2719117 CNV Deletion 23290073
esv2719128 CNV Deletion 23290073
esv2719140 CNV Deletion 23290073
esv270231 CNV Insertion 20981092
esv272593 CNV Insertion 20981092

Variation tolerance for UCK2 Gene

Residual Variation Intolerance Score: 42.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UCK2 Gene

HapMap Linkage Disequilibrium report
UCK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCK2 Gene

Disorders for UCK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UCK2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
testicular germ cell tumor
  • male germ cell tumor, somatic
- elite association
Search UCK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UCK2

Genetic Association Database (GAD)
UCK2
Human Genome Epidemiology (HuGE) Navigator
UCK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UCK2
genes like me logo Genes that share disorders with UCK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UCK2 Gene

Publications for UCK2 Gene

  1. Evaluation of the role of three candidate human kinases in the conversion of the hepatitis C virus inhibitor 2'-C-methyl-cytidine to its 5'-monophosphate metabolite. (PMID: 19883694) Golitsina N.L. … Standring D.N. (Antiviral Res. 2010) 23 67
  2. Downregulation of uridine-cytidine kinase like-1 decreases proliferation and enhances tumor susceptibility to lysis by apoptotic agents and natural killer cells. (PMID: 19653100) Ambrose E.C. … Kornbluth J. (Apoptosis 2009) 23 67
  3. Quantum mechanics/molecular mechanics investigation of the mechanism of phosphate transfer in human uridine-cytidine kinase 2. (PMID: 19532987) Smith A.J. … Houk K.N. (Org. Biomol. Chem. 2009) 23 67
  4. Synthesis and biologic study of IV-14, a new ribonucleoside radiotracer for tumor visualization. (PMID: 19837748) Zlatopolskiy B.D. … Reske S.N. (J. Nucl. Med. 2009) 23 67
  5. Key role of uridine kinase and uridine phosphorylase in the homeostatic regulation of purine and pyrimidine salvage in brain. (PMID: 17643556) Balestri F. … Ipata P.L. (Neurochem. Int. 2007) 23 67

Products for UCK2 Gene

Sources for UCK2 Gene

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