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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UCK2 Gene

protein-coding   GIFtS: 65
GCID: GC01P165796

uridine-cytidine kinase 2

(Previous name: uridine monophosphate kinase )
(Previous symbol: UMPK)
 Explore 17 diseases affiliated with
UCK2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UCK2    

Aliases
for UCK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Uridine-Cytidine Kinase 21 2     EC 2.7.1.483 8
UMPK1 2 3     TSA9032 5
Uridine Monophosphate Kinase1 2     UK2
Cytidine Monophosphokinase 22 3     Uridine Kinase2
Testis-Specific Protein TSA9032 3     UCK 23
Uridine Monophosphokinase 22 3     

External Ids:    HGNC: 125621   Entrez Gene: 73712   Ensembl: ENSG000001431797   OMIM: 6093295   UniProtKB: Q9BZX23   

Export aliases for UCK2 gene to outside databases

Previous GC identifers: GC01P162528 GC01P164063 GC01P137044


Summaries
for UCK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UCK2:
This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of
uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.(provided by
RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2
Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not
phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also
phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine,
5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and
N(4)-anisoylcytidine

Gene Wiki entry for UCK2


Genomic Views
for UCK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UCK2 gene promoter:
         USF1   USF2   USF-1:USF-2   E2F-1   E2F   HSF2   USF-1   IRF-7A   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UCK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for UCK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q24.1   HGNC cytogenetic band: 1p32

UCK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCK2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P165796:  view genomic region     (about GC identifiers)

Start:
 165,796,768 bp from pter      End:
 165,880,855 bp from pter
Size:
 84,088 bases      Orientation:
 plus strand

Proteins
for UCK2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2 (See protein sequence)
Recommended Name: Uridine-cytidine kinase 2  
Size: 261 amino acids; 29299 Da
Subunit: Homotetramer
6 PDB 3D structures from and Proteopedia for UCK2:
1UDW (3D)        1UEI (3D)        1UEJ (3D)        1UFQ (3D)        1UJ2 (3D)        1XRJ (3D)    
Secondary accessions: Q5VV91 Q7KZV3 Q92528 Q96KG5 Q9BU42
Alternative splicing: 2 isoforms:  Q9BZX2-1   Q9BZX2-2   

Explore the universe of human proteins at neXtProt for UCK2: NX_Q9BZX2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BZX2

    • 4/11 DME Specific Peptides for UCK2 (Q9BZX2) (see all 11)
     LLGQNEV  RGRDLEQ  DHPDAFD  HSRKEET 

    UCK2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036606.2  
    ENSEMBL proteins: 
     ENSP00000356853   ENSP00000361286  
    Reactome Protein details: Q9BZX2
    Human Recombinant Protein Products: 
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    Uscn Proteins for UCK2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005792microsome ----
    GO:0005829cytosol TAS--
    GO:0043231intracellular membrane-bounded organelle IEA--


    UCK2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for UCK2

    Protein Domains /
    Families
    for UCK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UCK2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000764 Uridine_kinase
     IPR006083 PRK/URK

    Graphical View of Domain Structure for InterPro Entry Q9BZX2

    ProtoNet protein and cluster: Q9BZX2

    1 Blocks protein family: IPB000764 Uridine kinase signature

    UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2
    Similarity: Belongs to the uridine kinase family


    Function
    for UCK2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2
    Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not
    phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also
    phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine,
    5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and
    N(4)-anisoylcytidine
    Catalytic activity: ATP + uridine = ADP + UMP
    Catalytic activity: ATP + cytidine = ADP + CMP

    Enzyme Number (IUBMB): EC 2.7.1.481 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCK2
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate UCK2 (see all 81):
    hsa-miR-194* hsa-miR-582-3p hsa-miR-199a-3p hsa-miR-4267 hsa-miR-877* hsa-miR-409-5p hsa-miR-1244 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: UCK2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UCK2 (see all 7)
    OriGene shRNA RFP: UCK2
    OriGene siRNA: UCK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCK2

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004849uridine kinase activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0016773phosphotransferase activity, alcohol group as acceptor IEA--


    UCK2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for UCK2:
     Increased cell death HMECs cel 


    Pathways & Interactions
    for UCK2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Pyrimidine metabolism
    		Pyrimidine metabolism1.00
    		Pyrimidine salvage reactions0.38
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3Fluoropyrimidine Activity
    		Fluoropyrimidine Activity1.00
    		Fluoropyrimidine Pathway, Pharmacokinetics0.73
    4pyrimidine ribonucleotides interconversion
    		salvage pathways of pyrimidine ribonucleotides0.45
    5Purine metabolism
    		Metabolism of nucleotides0.42

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for UCK2 
        Fluoropyrimidine Activity
    salvage pathways of pyrimidine ribonucleotides

    4        Reactome Pathways for UCK2
        Metabolism of nucleotides
    Metabolism
    Pyrimidine salvage reactions
    Pyrimidine metabolism

    1 PharmGKB Pathway for UCK2
        Fluoropyrimidine Pathway, Pharmacokinetics

    3         Kegg Pathways  (Kegg details for UCK2):
        Pyrimidine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways

    UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2
    Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
    Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1


    UCK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UCK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/23 Interacting proteins for UCK2 (Q9BZX23 ENSP000003568534) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK6Q9HC983, ENSP000003627024I2D: score=1 STRING: ENSP00000362702
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    TSC22D1Q157143, ENSP000003974354I2D: score=1 STRING: ENSP00000397435
    FYNP062413I2D: score=2 
    GRB2P629933I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0007631feeding behavior IEA--
    GO:0009165nucleotide biosynthetic process ----
    GO:0043097pyrimidine nucleoside salvage TAS--
    GO:0044206UMP salvage IEA--


    UCK2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UCK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UCK2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UCK2

    10/20 HMDB Compounds for UCK2 (see all 20)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cytidine1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)65-46-3--
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--
    Inosine triphosphateinosine 5'-(tetrahydrogen triphosphate) (see all 13)132-06-9--
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--

    6 DrugBank Compounds for UCK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Citric Acid-- 77-92-9target--17139284 17016423
    Cytidine-- --target--17139284 17016423
    Cytidine-5'-Monophosphate-- 84-52-6target--17139284 17016423
    Cytidine-5'-Triphosphate-- 65-47-4target--17139284 17016423
    Uridine 5'-Triphosphate-- 63-39-8target--17139284 17016423

    10/16 Novoseek chemical compound relationships for UCK2 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uridine 92.5 69 9923963 (7), 2161304 (4), 11272481 (4), 17643556 (3) (see all 29)
    ecyd 89.4 2 12903193 (1)
    ribonucleoside 79.9 1 12903193 (1)
    orotic acid 78.8 5 15913614 (1), 2167917 (1), 7872962 (1), 15508442 (1) (see all 5)
    cytidine 77.2 6 17890166 (1), 15735337 (1), 19532987 (1), 11272481 (1)
    5-fluorouridine 74.6 1 11137707 (1)
    thymidylate 71 4 8056448 (1), 16041392 (1), 2142213 (1), 15508442 (1)
    pyrimidine 68.4 5 17643556 (2), 1435081 (1)
    poly u 65.6 5 16041392 (1), 15735337 (1), 2161304 (1)
    fudr 64.8 1 2142213 (1)

    Search CenterWatch for drugs/clinical trials and news about UCK2 

    Transcripts
    for UCK2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UCK2 gene: 
    NM_012474.4  

    Unigene Cluster for UCK2:

    Uridine-cytidine kinase 2
    Hs.458360  [show with all ESTs]
    Unigene Representative Sequence: NM_012474
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367879 ENST00000462329 ENST00000464197 ENST00000469256 ENST00000470820
    ENST00000463772 ENST00000479872(uc001gdp.3 uc010plb.2) ENST00000475333
    ENST00000372212

    miRNA
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    hsa-miR-194* hsa-miR-582-3p hsa-miR-199a-3p hsa-miR-4267 hsa-miR-877* hsa-miR-409-5p hsa-miR-1244 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: UCK2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UCK2 (see all 7)
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    Clone
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    Additional cDNA sequence: 

    AB062451.1 AF236637.1 AK309739.1 BC002906.2 BT006860.1 CR456857.1 D78335.1 

    16 DOTS entries:

    DT.445046  DT.97843720  DT.213504  DT.100774693  DT.97842834  DT.121643844  DT.121359556  DT.100833732 
    DT.95076263  DT.405870  DT.92424348  DT.92424349  DT.100774692  DT.102837937  DT.121359668  DT.95076265 

    24/223 AceView cDNA sequences (see all 223):

    N29514 BM053091 AI078820 AI357130 CR608443 BM904895 BM994462 AI497650 
    AF236637 BX400983 AL698758 BM459096 BM825482 AA325580 Z45142 BU784819 
    AW516114 BM904054 BU179959 AK055795 BU158939 BP355275 AA468735 BU161711 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for UCK2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                          -     -     -                                 
    SP2:                          -     -     -           -                     
    SP3:                                                                        
    SP4:                                -     -                                 
    SP5:                                                                        


    ECgene alternative splicing isoforms for UCK2

    Expression
    for UCK2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UCK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGATGAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UCK2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMandibular CondyleBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UCK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UCK2

    SOURCE GeneReport for Unigene cluster: Hs.458360

    UniProtKB/Swiss-Prot: UCK2_HUMAN, Q9BZX2
    Tissue specificity: According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific

        SABiosciences Expression via Pathway-Focused PCR Array including UCK2: 
              Cardiotoxicity in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for UCK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for UCK2 gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UCK21 uridine-cytidine kinase 2 83.14(n)
    92.72(a)    		   424406  NM_001160071.1  NP_001153543.1 
    lizard
    (Anolis carolinensis)    		 Reptilia UPRT6
    UCK26
    		 --
    93(a)
    		 possible ortholog
    1 ↔ 1
    		 GL343825.1(74337-84296)
    4(73841376-73857190)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.132272 Xenopus laevis transcribed sequence with moderate similarity more 79.45(n)    CA987247.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC054665.12   -- 79.69(n)   335218  BC054665.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG55376
    CG63646
    		 --
    48(a)
    		 possible ortholog
    1 ↔ many
    		 3L(5804073-5805328)
    3R(20115897-20119093)
    worm
    (Caenorhabditis elegans)    		 Secernentea B0001.46
    		 Probable uridine-cytidine kinase
    		 42(a)
    		 possible ortholog
    		 IV(12135058-12137327)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons UKL36
    UKL56
    (see all 6)    		 putative uracil phosphoribosyltransferase
    (see all 6)    		 22(a)
    21(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 1(20860609-20864266)
    3(10155555-10157931)
    rice
    (Oryza sativa)    		 Liliopsida AK103877.12   -- 76.47(n)    AK103877.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria udk6
    		 uridine/cytidine kinase
    		 34(a)
    		 possible ortholog
    		 Chromosome(2140331-2140972)


    ENSEMBL Gene Tree for UCK2 (if available)
    TreeFam Gene Tree for UCK2 (if available) 

    Paralogs
    for UCK2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UCK2 gene
    UCKL12  UCK12  
    2 SIMAP similar genes for UCK2 using alignment to 2 protein entries:     UCK2_HUMAN (see all proteins):
    UCK1    UCKL1

    UCK2 for paralogs           About GeneDecksing



    Genomic Variants
    for UCK2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1511 NCBI SNPs in UCK2 are shown (see all 1511)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1134293911,2
    		F,--165794761(+) TCCTCG/CTGCCT 1 -- us2k12Minor allele frequency- C:0.50CSA 4
    rs1404361161,2
    		--165794844(+) TGGGGG/TTCTCA 1 -- us2k10--------
    rs1922252141,2
    		--165794873(+) TCTCAA/GACTCC 1 -- us2k10--------
    rs1452258031,2
    		--165794934(+) GGCATA/GAGCCA 1 -- us2k10--------
    rs1479723791,2
    		--165794950(+) CTGGCC/TTTTGG 1 -- us2k10--------
    rs1416417331,2
    		--165794979(+) CTCTTC/TTCCTT 1 -- us2k10--------
    rs1501025591,2
    		--165795003(+) CCCCAC/TGCTAA 1 -- us2k10--------
    rs1384719451,2
    		--165795134(+) AGGACC/TACCTA 1 -- us2k10--------
    rs1439870451,2
    		--165795160(+) ATAGCG/TATTTG 1 -- us2k10--------
    rs741189071,2
    		C,F,--165795234(+) TCTCCC/TCATCT 1 -- us2k13Minor allele frequency- T:0.05WA 122

    HapMap Linkage Disequilibrium report for UCK2 (165796768 - 165880855 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for UCK2
         3 CNVs: 1341 9380 48166

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    Disorders / Diseases
    for UCK2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UCK2 for disorders           About GeneDecksing

    OMIM gene information: 609329    OMIM disorders: --

    17 diseases for UCK2:    About MalaCards
    bartter disease    acute lymphoblastic leukemia    lymphoblastic leukemia    burkitt's lymphoma
    essential hypertension    hepatitis c    fibrosarcoma    colon carcinoma
    hypertension    hepatocellular carcinoma    t-cell leukemia    leukemia
    colon cancer    hepatitis    pneumonia    carcinoma
    alcoholism

    1 disease from the University of Copenhagen DISEASES database for UCK2:
    Ehrlichiosis

    3 Novoseek disease relationships for UCK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    solid tumor 14.3 1 2167917 (1)
    tumors 3.79 8 12149149 (2), 15280220 (1), 19837748 (1), 19653100 (1) (see all 6)
    cancer 0 6 12149149 (2), 19532987 (1), 12876357 (1)

    Human Genome Epidemiology (HuGE) Navigator: UCK2 (2 documents)

    Export disorders for UCK2 gene to outside databases

    Publications
    for UCK2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UCK2 gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with UCK2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. (PubMed id 11306702)1, 2, 9 Van Rompay A.R.... Karlsson A. (2001)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase. (PubMed id 15130468)1, 2 Suzuki N.N....Inagaki F. (2004)
    5. Cloning and expression of uridine/cytidine kinase cDNA from human fibrosarcoma cells. (PubMed id 11494055)1, 2 Koizumi K....Fukushima M. (2001)
    6. Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. (PubMed id 8812458)1, 2 Ozaki K.... Nakamura Y. (1996)
    7. Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative. (PubMed id 15735337)2, 9 Appleby T.C.... Yao N. (2005)
    8. A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides. (PubMed id 15280220)1, 9 Murata D....Sasaki T. (2004)
    9. Quantum mechanics/molecular mechanics investigation o f the mechanism of phosphate transfer in human uridine-cytidine kinase 2. (PubMed id 19532987)1, 9 Smith A.J....Houk K.N. (2009)
    10. Crystallization and preliminary X-ray analysis of human uridine-cytidine kinase 2. (PubMed id 12876357)1, 9 Suzuki N.N....Inagaki F. (2003)

    External Searches for UCK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UCK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7371 HGNC: 12562 AceView: UCK2 Ensembl:ENSG00000143179 euGenes: HUgn7371
    ECgene: UCK2 Kegg: 7371 H-InvDB: UCK2

    Other Databases showing UCK2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UCK2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UCK2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UCK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UCK2 gene:
    Search GeneIP for patents involving UCK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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