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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UCK1 Gene

protein-coding   GIFtS: 55
GCID: GC09M134399

uridine-cytidine kinase 1
 Explore 4 diseases affiliated with
UCK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UCK1    

Aliases
for UCK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Uridine-Cytidine Kinase 11 2     UCK 12 3
URK11 2 3     EC 2.7.1.483 8
Cytidine Monophosphokinase 12 3     FLJ122551
Uridine Monophosphokinase 12 3     

External Ids:    HGNC: 148591   Entrez Gene: 835492   Ensembl: ENSG000001307177   OMIM: 6093285   UniProtKB: Q9HA473   

Export aliases for UCK1 gene to outside databases

Previous GC identifers: GC09M125413 GC09M125945 GC09M127752 GC09M129675 GC09M131428 GC09M133389 GC09M103893


Summaries
for UCK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UCK1:
This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine
monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine
ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a
phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. (provided by
RefSeq, May 2012)

UniProtKB/Swiss-Prot: UCK1_HUMAN, Q9HA47
Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not
phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also
phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine,
5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and
N(4)-anisoylcytidine




Genomic Views
for UCK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_035014.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UCK1 gene promoter:
         Max1   p53   RREB-1   LUN-1   NRSF form 2   FOXL1   N-Myc   Zic1   ZIC2/Zic2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UCK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for UCK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13   Ensembl cytogenetic band:  9q34.13   HGNC cytogenetic band: 9q34.1

UCK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCK1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M134399:  view genomic region     (about GC identifiers)

Start:
 134,399,183 bp from pter      End:
 134,406,662 bp from pter
Size:
 7,480 bases      Orientation:
 minus strand

Proteins
for UCK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UCK1_HUMAN, Q9HA47 (See protein sequence)
Recommended Name: Uridine-cytidine kinase 1  
Size: 277 amino acids; 31435 Da
2 PDB 3D structures from and Proteopedia for UCK1:
2JEO (3D)        2UVQ (3D)    
Secondary accessions: Q5JT10 Q5JT12 Q5JT13 Q6IA74 Q96BJ0
Alternative splicing: 3 isoforms:  Q9HA47-1   Q9HA47-2   Q9HA47-3   (Ref.8 (AAH15547) sequence is in conflict in position: 180:A->T)

Explore the universe of human proteins at neXtProt for UCK1: NX_Q9HA47

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HA47

    • 4/12 DME Specific Peptides for UCK1 (Q9HA47) (see all 12)
     VEVPTYD  LLGQNEV  RGRDLEQ  QEIRDMF 

    UCK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001129426.1  NP_001248379.1  NP_001248380.1  NP_113620.1  

    ENSEMBL proteins: 
     ENSP00000361289   ENSP00000361282   ENSP00000432363   ENSP00000361285   ENSP00000361284  
    Reactome Protein details: Q9HA47
    Human Recombinant Protein Products: 
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    Novus Biologicals UCK1 Protein
    Novus Biologicals UCK1 Lysate
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    Uscn Proteins for UCK1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    UCK1 for ontologies           About GeneDecksing



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    Uscn Antibodies for UCK1
    Search ThermoFisher Antibodies for UCK1

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    Uscn ELISAs and CLIAs for UCK1

    Protein Domains /
    Families
    for UCK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UCK1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000764 Uridine_kinase
     IPR006083 PRK/URK

    Graphical View of Domain Structure for InterPro Entry Q9HA47

    ProtoNet protein and cluster: Q9HA47

    1 Blocks protein family: IPB000764 Uridine kinase signature

    UniProtKB/Swiss-Prot: UCK1_HUMAN, Q9HA47
    Similarity: Belongs to the uridine kinase family


    Function
    for UCK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UCK1_HUMAN, Q9HA47
    Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not
    phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also
    phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine,
    5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and
    N(4)-anisoylcytidine
    Catalytic activity: ATP + uridine = ADP + UMP
    Catalytic activity: ATP + cytidine = ADP + CMP

    Enzyme Number (IUBMB): EC 2.7.1.481 2

    miRNA
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    hsa-miR-4264 hsa-miR-4276
    SwitchGear 3'UTR luciferase reporter plasmid: UCK1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: UCK1
    OriGene siRNA: UCK1
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCK1 

    Cell Line
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    Search LifeMap BioReagents cell lines for UCK1

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004849uridine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0016773phosphotransferase activity, alcohol group as acceptor IEA--
    GO:0019206nucleoside kinase activity EXP--


    UCK1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for UCK1:
     Decreased CYP1A1 activity afte  Decreased viability 


    Pathways & Interactions
    for UCK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Pyrimidine metabolism
    		Pyrimidine metabolism1.00
    		Pyrimidine salvage reactions0.38
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3Fluoropyrimidine Activity
    		Fluoropyrimidine Activity1.00
    		Fluoropyrimidine Pathway, Pharmacokinetics0.73
    4pyrimidine ribonucleotides interconversion
    		salvage pathways of pyrimidine ribonucleotides0.45
    5Purine metabolism
    		Metabolism of nucleotides0.42

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for UCK1 
        Fluoropyrimidine Activity
    salvage pathways of pyrimidine ribonucleotides

    4        Reactome Pathways for UCK1
        Metabolism of nucleotides
    Metabolism
    Pyrimidine salvage reactions
    Pyrimidine metabolism

    1 PharmGKB Pathway for UCK1
        Fluoropyrimidine Pathway, Pharmacokinetics

    3         Kegg Pathways  (Kegg details for UCK1):
        Pyrimidine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways

    UniProtKB/Swiss-Prot: UCK1_HUMAN, Q9HA47
    Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
    Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1


    UCK1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UCK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for UCK1 (Q9HA473 ENSP000003612894) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG2P168853I2D: score=2 
    CDAENSP000003642124STRING: ENSP00000364212
    AICDAENSP000002293354STRING: ENSP00000229335
    PLA2G12AENSP000002435014STRING: ENSP00000243501
    UCKL1ENSP000003461554STRING: ENSP00000346155
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0009165nucleotide biosynthetic process ----
    GO:0043097pyrimidine nucleoside salvage TAS--
    GO:0044206UMP salvage IEA--
    GO:0044211CTP salvage IEA--


    UCK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UCK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UCK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UCK1

    10/20 HMDB Compounds for UCK1 (see all 20)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cytidine1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)65-46-3--
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--
    Inosine triphosphateinosine 5'-(tetrahydrogen triphosphate) (see all 13)132-06-9--
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--
    2 Novoseek chemical compound relationships for UCK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    deoxycytidine 75.6 4 19883694 (1), 17101674 (1)
    uridine 73.9 2 11872485 (1)

    Search CenterWatch for drugs/clinical trials and news about UCK1 

    Transcripts
    for UCK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UCK1 gene (4 alternative transcripts): 
    NM_001135954.1  NM_001261450.1  NM_001261451.1  NM_031432.2  

    Unigene Cluster for UCK1:

    Uridine-cytidine kinase 1
    Hs.9597  [show with all ESTs]
    Unigene Representative Sequence: AK057848
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372215(uc004cay.3 uc004cba.3) ENST00000372208 ENST00000491309(uc004caz.3)
    ENST00000372211(uc010mzk.3) ENST00000372210 ENST00000484876 ENST00000494584
    ENST00000459858 ENST00000482398

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCK1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate UCK1:
    hsa-miR-4264 hsa-miR-4276
    SwitchGear 3'UTR luciferase reporter plasmid: UCK1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF125106.1 AF237290.1 AF254133.1 AK022317.1 AK057848.1 AK295471.1 AK307475.1 BC015547.1 
    BC091495.1 CR457281.1 

    14 DOTS entries:

    DT.100830102  DT.91743477  DT.95163729  DT.100796204  DT.100796198  DT.95163724  DT.91743485  DT.435070 
    DT.121187470  DT.100768756  DT.75133596  DT.75153844  DT.121187552  DT.91743486 

    24/235 AceView cDNA sequences (see all 235):

    BG390519 BQ680950 BG826894 BM917506 AI953663 BF732830 BM835278 CD514811 
    AW271442 BQ072501 BF726997 BQ900975 CD674940 BM545603 BM822058 BF002859 
    BQ673728 BU838101 CR611362 BM981560 AW157648 BQ935919 AF237290 BM827668 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for UCK1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:              -     -                 -           -           -                     
    SP2:                                      -           -                                 
    SP3:                    -                 -           -           -                     
    SP4:              -                       -           -           -                     
    SP5:                    -                 -                                             


    ECgene alternative splicing isoforms for UCK1

    Expression
    for UCK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UCK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAACACCCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See UCK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UCK1

    SOURCE GeneReport for Unigene cluster: Hs.9597

    UniProtKB/Swiss-Prot: UCK1_HUMAN, Q9HA47
    Tissue specificity: Ubiquitous

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    In Situ
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    Orthologs
    for UCK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for UCK1 gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UCK11 uridine-cytidine kinase 1 81.48(n)
    88.15(a)    		   771901  XM_001235115.2  XP_001235116.2 
    lizard
    (Anolis carolinensis)    		 Reptilia UPRT6
    UCK16
    		 --
    81(a)
    		 possible ortholog
    1 ↔ 1
    		 GL343825.1(74337-84296)
    GL344906.1(9732-12666)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC687362 uridine-cytidine kinase 1 78.49(n)    BC060421.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii uck11 uridine-cytidine kinase 1 72.8(n)
    81.23(a)    		   447928  NM_001004666.1  NP_001004666.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG63643 uridine kinase 67(a)   95F10   --
    worm
    (Caenorhabditis elegans)    		 Secernentea B0001.43 uridine kinase like 50(a)   IV(12136254-12137883)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons UKL56
    UKL26
    (see all 6)    		 putative uracil phosphoribosyltransferase
    (see all 6)    		 21(a)
    20(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 3(10155555-10157931)
    3(10039234-10043066)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 6)    		 uridine/cytidine kinase-like 1, putative, expresse...
    uridine/cytidine kinase-like 1, putative, expresse...
    (see all 6)    		 21(a)
    21(a)
    (see all 6)    		 many ↔ many
    many ↔ many
    (see all 6)    		 2(9928815-9937416)
    11(9028829-9037244)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria udk6
    		 uridine/cytidine kinase
    		 33(a)
    		 possible ortholog
    		 Chromosome(2140331-2140972)


    ENSEMBL Gene Tree for UCK1 (if available)
    TreeFam Gene Tree for UCK1 (if available) 

    Paralogs
    for UCK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UCK1 gene
    UCK22  UCKL12  
    2 SIMAP similar genes for UCK1 using alignment to 3 protein entries:     UCK1_HUMAN (see all proteins):
    UCK2    UCKL1

    UCK1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UCK1
    PGOHUM00000258080


    Genomic Variants
    for UCK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/215 NCBI SNPs in UCK1 are shown (see all 215)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1452138961,2
    		--134399696(+) GCCTCC/TGCTGC 4 -- ut310--------
    rs727576671,2
    		C,--134399709(+) TCTGCC/TCTACT 4 -- ut310--------
    rs1902550321,2
    		--134399890(+) ATTAGA/GTTTGT 4 -- ut310--------
    rs735577111,2
    		C,--134399919(+) TGTTAC/TGAAAC 4 -- ut311Minor allele frequency- T:0.50WA 2
    rs1455941851,2
    		C,--134399921(+) TTATG-/AA    
       ACAGA    AAACA     		4 -- ut310--------
    rs2021151001,2
    		--134399932(+) AAAAC-/AGAAAAC 4 -- ut310--------
    rs2017129961,2
    		C--134399999(+) TATGTA/GTGTGA 4 -- ut310--------
    rs106090621,2
    		C,--134400001(+) TGTGT-/GTGA  
                GTGTG     		4 -- ut311Minor allele frequency- GTGA:0.50NA 2
    rs726193241,2
    		C,--134400004(+) GTGTGA/TGTGTG 4 -- ut310--------
    rs1477436661,2
    		C,--134400029(+) ACTGG-/AAAAAA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for UCK1 (134399183 - 134406662 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for UCK1
         6 CNVs: 8633 1833 2839 31531 3783 9626

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    Disorders / Diseases
    for UCK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UCK1 for disorders           About GeneDecksing

    OMIM gene information: 609328    OMIM disorders: --

    4 diseases for UCK1:    About MalaCards
    estrogen excess    hepatitis c    hepatitis    alcoholism

    1 Novoseek disease relationship for UCK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0.79 3 12149149 (1), 12876357 (1)


    Export disorders for UCK1 gene to outside databases

    Publications
    for UCK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UCK1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with UCK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. (PubMed id 11306702)1, 2, 3, 9 Van Rompay A.R.... Karlsson A. (2001)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Human uridine-cytidine kinase phosphorylation of ribavirin: a convenient method for activation of ribavirin for conjugation to proteins. (PubMed id 18080217)1, 9 Virovic Jukic L....Wu G.Y. (2008)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for UCK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UCK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83549 HGNC: 14859 AceView: UCK1 Ensembl:ENSG00000130717 euGenes: HUgn83549
    ECgene: UCK1 Kegg: 83549 H-InvDB: UCK1

    Other Databases showing UCK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UCK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UCK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UCK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UCK1 gene:
    Search GeneIP for patents involving UCK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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