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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UCK1 Gene

protein-coding   GIFtS: 56
GCID: GC09M134399

Uridine-Cytidine Kinase 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Uridine-Cytidine Kinase 11 2
Cytidine Monophosphokinase 12 3
Uridine Monophosphokinase 12 3
URK12 3
UCK 12 3
EC 2.7.1.483 8

External Ids:    HGNC: 148591   Entrez Gene: 835492   Ensembl: ENSG000001307177   OMIM: 6093285   UniProtKB: Q9HA473   

Export aliases for UCK1 gene to outside databases

Previous GC identifers: GC09M125413 GC09M125945 GC09M127752 GC09M129675 GC09M131428 GC09M133389 GC09M103893


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UCK1 Gene:
This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine
monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or
purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP
as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms.
(provided by RefSeq, May 2012)

GeneCards Summary for UCK1 Gene: 
UCK1 (uridine-cytidine kinase 1) is a protein-coding gene. Diseases associated with UCK1 include estrogen excess, and hepatitis c, and among its related super-pathways are Fluoropyrimidine Pathway, Pharmacokinetics and Metabolic pathways. GO annotations related to this gene include uridine kinase activity and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is UCK2.

UniProtKB/Swiss-Prot: UCK1_HUMAN, Q9HA47
Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not
phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also
phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine,
5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine,
and N(4)-anisoylcytidine




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_035014.4  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UCK1 gene promoter:
         Max1   p53   RREB-1   LUN-1   NRSF form 2   FOXL1   N-Myc   Zic1   ZIC2/Zic2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for UCK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13   Ensembl cytogenetic band:  9q34.13   HGNC cytogenetic band: 9q34.1

UCK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCK1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M134399:  view genomic region     (about GC identifiers)

Start:
134,399,183 bp from pter      End:
134,406,662 bp from pter
Size:
7,480 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UCK1_HUMAN, Q9HA47 (See protein sequence)
Recommended Name: Uridine-cytidine kinase 1  
Size: 277 amino acids; 31435 Da
2 PDB 3D structures from and Proteopedia for UCK1:
2JEO (3D)        2UVQ (3D)    
Secondary accessions: Q5JT10 Q5JT12 Q5JT13 Q6IA74 Q96BJ0
Alternative splicing: 3 isoforms:  Q9HA47-1   Q9HA47-2   Q9HA47-3   (Ref.8 (AAH15547) sequence is in conflict in position: 180:A->T)

Explore the universe of human proteins at neXtProt for UCK1: NX_Q9HA47

Explore proteomics data for UCK1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HA47

  • 4/12 DME Specific Peptides for UCK1 (Q9HA47) (see all 12)
     VEVPTYD  LLGQNEV  RGRDLEQ  QEIRDMF 

    UCK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UCK1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001129426.1  NP_001248379.1  NP_001248380.1  NP_113620.1  

    ENSEMBL proteins: 
     ENSP00000361284   ENSP00000361285   ENSP00000432363   ENSP00000361282   ENSP00000361289  
    Reactome Protein details: Q9HA47
    Human Recombinant Protein Products for UCK1: 
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    Novus Biologicals UCK1 Protein
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for UCK1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    UCK1 for ontologies           About GeneDecksing



    UCK1 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for UCK1 
    Cloud-Clone Corp. CLIAs for UCK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR000764 Uridine_kinase
     IPR006083 PRK/URK

    Graphical View of Domain Structure for InterPro Entry Q9HA47

    ProtoNet protein and cluster: Q9HA47

    1 Blocks protein domain: IPB000764 Uridine kinase signature

    UniProtKB/Swiss-Prot: UCK1_HUMAN, Q9HA47
    Similarity: Belongs to the uridine kinase family


    UCK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UCK1_HUMAN, Q9HA47
    Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not
    phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also
    phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine,
    5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine,
    and N(4)-anisoylcytidine
    Catalytic activity: ATP + uridine = ADP + UMP
    Catalytic activity: ATP + cytidine = ADP + CMP

         Enzyme Number (IUBMB): EC 2.7.1.481 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004140dephospho-CoA kinase activity ----
    GO:0004849uridine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
    GO:0016773phosphotransferase activity, alcohol group as acceptor IEA--
         
    UCK1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for UCK1:
     Decreased CYP1A1 activity afte  Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UCK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UCK1

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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate UCK1:
    hsa-miR-4264 hsa-miR-4276
    SwitchGear 3'UTR luciferase reporter plasmidUCK1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UCK1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Fluoropyrimidine Activity
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Pyrimidine metabolism
    Pyrimidine metabolism0.50
    Pyrimidine salvage reactions0.38
    4Purine metabolism
    Metabolism of nucleotides0.42
    5Purine metabolism
    Pyrimidine metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for UCK1
        Fluoropyrimidine Activity
    pyrimidine ribonucleosides salvage I

    4        Reactome Pathways for UCK1
        Metabolism of nucleotides
    Metabolism
    Pyrimidine salvage reactions
    Pyrimidine metabolism

    1 PharmGKB Pathway for UCK1
        Fluoropyrimidine Pathway, Pharmacokinetics

    3         Kegg Pathways  (Kegg details for UCK1):
        Pyrimidine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways

    UniProtKB/Swiss-Prot: UCK1_HUMAN, Q9HA47
    Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
    Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1


    UCK1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UCK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for UCK1 (Q9HA473 ENSP000003612894) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG2P168853I2D: score=2 
    CDAENSP000003642124STRING: ENSP00000364212
    AICDAENSP000002293354STRING: ENSP00000229335
    PLA2G12AENSP000002435014STRING: ENSP00000243501
    UCKL1ENSP000003461554STRING: ENSP00000346155
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0008152metabolic process ----
    GO:0015937coenzyme A biosynthetic process ----
    GO:0043097pyrimidine nucleoside salvage TAS--
    GO:0044206UMP salvage IEA--

    UCK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UCK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UCK1

    10/20 HMDB Compounds for UCK1 (see all 20)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Cytidine1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)65-46-3--
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    IDP5'-IDP (see all 10)86-04-4--
    Inosine triphosphateinosine 5'-(tetrahydrogen triphosphate) (see all 13)132-06-9--
    Thymidine 5'-triphosphate2'-Deoxythymidine 5'-triphosphate (see all 13)365-08-2--

    2 Novoseek inferred chemical compound relationships for UCK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    deoxycytidine 75.6 4 19883694 (1), 17101674 (1)
    uridine 73.9 2 11872485 (1)

    Search CenterWatch for drugs/clinical trials and news about UCK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UCK1 gene (4 alternative transcripts): 
    NM_001135954.1  NM_001261450.1  NM_001261451.1  NM_031432.2  

    Unigene Cluster for UCK1:

    Uridine-cytidine kinase 1
    Hs.9597  [show with all ESTs]
    Unigene Representative Sequence: AK057848
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372210 ENST00000372211(uc010mzk.3) ENST00000491309(uc004caz.3)
    ENST00000372208 ENST00000372215(uc004cay.3 uc004cba.3) ENST00000484876
    ENST00000494584 ENST00000459858 ENST00000482398
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate UCK1:
    hsa-miR-4264 hsa-miR-4276
    SwitchGear 3'UTR luciferase reporter plasmidUCK1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF125106.1 AF237290.1 AF254133.1 AK022317.1 AK057848.1 AK295471.1 AK307475.1 BC015547.1 
    BC091495.1 CR457281.1 

    14 DOTS entries:

    DT.100830102  DT.91743477  DT.95163729  DT.100796204  DT.100796198  DT.95163724  DT.91743485  DT.435070 
    DT.121187470  DT.100768756  DT.75133596  DT.75153844  DT.121187552  DT.91743486 

    24/235 AceView cDNA sequences (see all 235):

    BM981560 BM822058 BM827668 CD514811 BU838101 BF002859 BQ072501 BQ680950 
    BQ935919 AI953663 BM835278 BF732830 AW157648 BG390519 CD674940 CR611362 
    BM917506 BQ673728 AW271442 BG826894 BM545603 AF237290 BQ900975 BF726997 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for UCK1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:              -     -                 -           -           -                     
    SP2:                                      -           -                                 
    SP3:                    -                 -           -           -                     
    SP4:              -                       -           -           -                     
    SP5:                    -                 -                                             


    ECgene alternative splicing isoforms for UCK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UCK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACACCCG
    UCK1 Expression
    About this image


    See UCK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UCK1

    SOURCE GeneReport for Unigene cluster: Hs.9597

    UniProtKB/Swiss-Prot: UCK1_HUMAN, Q9HA47
    Tissue specificity: Ubiquitous

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UCK1 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uck11 , 5 uridine-cytidine kinase 11, 5 86.76(n)1
    91.7(a)1
      2 (22.09 cM)5
    222451  NM_011675.21  NP_035805.21 
     322550025 
    chicken
    (Gallus gallus)
    Aves UCK11 uridine-cytidine kinase 1 81.48(n)
    88.15(a)
      771901  XM_001235115.2  XP_001235116.2 
    lizard
    (Anolis carolinensis)
    Reptilia UCK16
    Uncharacterized protein
    80(a)
    1 ↔ 1
    GL344906.1(9732-12666)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687362 uridine-cytidine kinase 1 78.49(n)    BC060421.1 
    zebrafish
    (Danio rerio)
    Actinopterygii uck11 uridine-cytidine kinase 1 72.8(n)
    81.23(a)
      447928  NM_001004666.1  NP_001004666.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63643 uridine kinase 67(a)   95F10   --
    worm
    (Caenorhabditis elegans)
    Secernentea B0001.43 uridine kinase like 50(a)   IV(12136254-12137883)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes URK16
    Uridine/cytidine kinase, component of the pyrimidi...
    17(a)
    1 → many
    XIV(647432-648937)


    ENSEMBL Gene Tree for UCK1 (if available)
    TreeFam Gene Tree for UCK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UCK1 gene
    UCK22  UCKL12  
    2 SIMAP similar genes for UCK1 using alignment to 3 protein entries:     UCK1_HUMAN (see all proteins):
    UCK2    UCKL1

    UCK1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UCK1
    PGOHUM00000258080


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/278 SNPs in UCK1 are shown (see all 278)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452138961,2
    --134399696(+) GCCTCC/TGCTGC 4 -- ut310--------
    rs727576671,2
    C--134399709(+) TCTGCC/TCTACT 4 -- ut310--------
    rs1902550321,2
    --134399890(+) ATTAGA/GTTTGT 4 -- ut310--------
    rs735577111,2
    C--134399919(+) TGTTAC/TGAAAC 4 -- ut311Minor allele frequency- T:0.50WA 2
    rs1455941851,2
    C--134399921(+) TTATG-/AA    
       ACAGA
    AAACA
    4 -- ut310--------
    rs2021151001,2
    --134399932(+) AAAAC-/AGAAAAC 4 -- ut310--------
    rs2017129961,2
    C--134399999(+) TATGTA/GTGTGA 4 -- ut310--------
    rs726193241,2
    C--134400004(+) GTGTGA/TGTGTG 4 -- ut310--------
    rs1477436661,2
    C--134400029(+) ACTGG-/AAAAAA 4 -- ut310--------
    rs1430820011,2
    --134400199(+) TTAAAC/TCGCAA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for UCK1 (134399183 - 134406662 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for UCK1 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv8314n71CNV Loss21882294
    nsv893991CNV Loss21882294
    dgv8313n71CNV Loss21882294
    nsv831741CNV Loss17160897
    nsv831742CNV Loss17160897
    nsv517936CNV Loss19592680
    nsv438114CNV Loss16468122
    nsv466603CNV Loss19166990
    nsv893990CNV Loss21882294
    dgv8315n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609328    OMIM disorders: --

    5 diseases for UCK1:    About MalaCards
    estrogen excess    hepatitis c    alcoholism    pneumonia
    hepatitis


    UCK1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for UCK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0.79 3 12149149 (1), 12876357 (1)


    Export disorders for UCK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UCK1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with UCK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. (PubMed id 11306702)1, 2, 3, 9 Van Rompay A.R.... Karlsson A. (2001)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Human uridine-cytidine kinase phosphorylation of ribavirin: a convenient method for activation of ribavirin for conjugation to proteins. (PubMed id 18080217)1, 9 Virovic Jukic L....Wu G.Y. (2008)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83549 HGNC: 14859 AceView: UCK1 Ensembl:ENSG00000130717 euGenes: HUgn83549
    ECgene: UCK1 Kegg: 83549 H-InvDB: UCK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UCK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UCK1 gene:
    Search GeneIP for patents involving UCK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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