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Aliases for UCK1 Gene

Aliases for UCK1 Gene

  • Uridine-Cytidine Kinase 1 2 3
  • Cytidine Monophosphokinase 1 3 4
  • Uridine Monophosphokinase 1 3 4
  • EC 2.7.1.48 4 63
  • UCK 1 3 4
  • URK1 3 4

External Ids for UCK1 Gene

Summaries for UCK1 Gene

Entrez Gene Summary for UCK1 Gene

  • This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]

GeneCards Summary for UCK1 Gene

UCK1 (Uridine-Cytidine Kinase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and uridine kinase activity. An important paralog of this gene is UCK2.

UniProtKB/Swiss-Prot for UCK1 Gene

  • Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCK1 Gene

Genomics for UCK1 Gene

Genomic Location for UCK1 Gene

Start:
131,523,796 bp from pter
End:
131,531,275 bp from pter
Size:
7,480 bases
Orientation:
Minus strand

Genomic View for UCK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UCK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCK1 Gene

Regulatory Elements for UCK1 Gene

Proteins for UCK1 Gene

  • Protein details for UCK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HA47-UCK1_HUMAN
    Recommended name:
    Uridine-cytidine kinase 1
    Protein Accession:
    Q9HA47
    Secondary Accessions:
    • Q5JT09
    • Q5JT10
    • Q5JT12
    • Q5JT13
    • Q6IA74
    • Q96BJ0

    Protein attributes for UCK1 Gene

    Size:
    277 amino acids
    Molecular mass:
    31435 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UCK1 Gene

    Alternative splice isoforms for UCK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UCK1 Gene

Proteomics data for UCK1 Gene at MOPED

Post-translational modifications for UCK1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys81 and Lys204

Other Protein References for UCK1 Gene

Domains for UCK1 Gene

Protein Domains for UCK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HA47

UniProtKB/Swiss-Prot:

UCK1_HUMAN
Family:
  • Belongs to the uridine kinase family.:
    • Q9HA47
genes like me logo Genes that share domains with UCK1: view

No data available for Gene Families for UCK1 Gene

Function for UCK1 Gene

Molecular function for UCK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + uridine = ADP + UMP
UniProtKB/Swiss-Prot CatalyticActivity: ATP + cytidine = ADP + CMP
UniProtKB/Swiss-Prot Function: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine

Enzyme Numbers (IUBMB) for UCK1 Gene

Gene Ontology (GO) - Molecular Function for UCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004140 dephospho-CoA kinase activity --
GO:0004849 uridine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
GO:0019206 nucleoside kinase activity EXP --
genes like me logo Genes that share ontologies with UCK1: view

Phenotypes for UCK1 Gene

genes like me logo Genes that share phenotypes with UCK1: view

miRNA for UCK1 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UCK1 Gene

Localization for UCK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCK1 Gene COMPARTMENTS Subcellular localization image for UCK1 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for UCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UCK1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UCK1 Gene

Pathways for UCK1 Gene

genes like me logo Genes that share pathways with UCK1: view

Pathways by source for UCK1 Gene

UniProtKB/Swiss-Prot Q9HA47-UCK1_HUMAN

  • Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
  • Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1

Interacting Proteins for UCK1 Gene

Gene Ontology (GO) - Biological Process for UCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0008152 metabolic process --
GO:0015937 coenzyme A biosynthetic process --
GO:0016310 phosphorylation IEA --
GO:0043097 pyrimidine nucleoside salvage TAS --
genes like me logo Genes that share ontologies with UCK1: view

Compounds for UCK1 Gene

(20) HMDB Compounds for UCK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Cytidine
  • 1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine
65-46-3
Cytidine monophosphate
  • 5'-CMP
63-37-6
dADP
  • 2'-deoxyadenosine-5'-diphosphate
2793-06-8

(2) Novoseek inferred chemical compound relationships for UCK1 Gene

Compound -log(P) Hits PubMed IDs
deoxycytidine 75.6 2
uridine 73.9 1
genes like me logo Genes that share compounds with UCK1: view

Transcripts for UCK1 Gene

Unigene Clusters for UCK1 Gene

Uridine-cytidine kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCK1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2: - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6: -
SP7: -

Relevant External Links for UCK1 Gene

GeneLoc Exon Structure for
UCK1
ECgene alternative splicing isoforms for
UCK1

Expression for UCK1 Gene

mRNA expression in normal human tissues for UCK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UCK1 Gene

SOURCE GeneReport for Unigene cluster for UCK1 Gene Hs.9597

mRNA Expression by UniProt/SwissProt for UCK1 Gene

Q9HA47-UCK1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with UCK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UCK1 Gene

Orthologs for UCK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UCK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UCK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UCK1 35
  • 87.85 (n)
  • 93.86 (a)
UCK1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCK1 35
  • 88.97 (n)
  • 93.05 (a)
UCK1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uck1 35
  • 86.76 (n)
  • 91.7 (a)
Uck1 16
Uck1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UCK1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UCK1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uck1 35
  • 87.61 (n)
  • 92.06 (a)
chicken
(Gallus gallus)
Aves UCK1 35
  • 81.48 (n)
  • 88.15 (a)
UCK1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UCK1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68736 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491950 35
  • 77.74 (n)
  • 85.24 (a)
zebrafish
(Danio rerio)
Actinopterygii uck1 35
  • 72.5 (n)
  • 80.61 (a)
uck1 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6364 36
  • 48 (a)
OneToMany
CG6364 37
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea B0001.4 36
  • 42 (a)
OneToMany
B0001.4 37
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URK1 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6934 36
  • 53 (a)
OneToMany
Species with no ortholog for UCK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UCK1 Gene

ENSEMBL:
Gene Tree for UCK1 (if available)
TreeFam:
Gene Tree for UCK1 (if available)

Paralogs for UCK1 Gene

Paralogs for UCK1 Gene

Selected SIMAP similar genes for UCK1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for UCK1 Gene

genes like me logo Genes that share paralogs with UCK1: view

Variants for UCK1 Gene

Sequence variations from dbSNP and Humsavar for UCK1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2282010 -- 131,530,211(-) CTGTG(A/G)TCCTG intron-variant
rs2282011 -- 131,530,028(-) AGATG(C/T)GGCAG intron-variant
rs2296956 -- 131,529,397(-) CCTCC(C/G)CCGGT intron-variant
rs2296957 -- 131,525,948(-) ATCCC(A/G/T)CGAGG missense, reference, synonymous-codon, nc-transcript-variant
rs3808830 -- 131,533,047(+) CGTAG(C/T)GAAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UCK1 Gene

Variant ID Type Subtype PubMed ID
essv2695 CNV CNV 17122850
dgv2424e1 CNV Complex 17122850
nsv818728 CNV Gain 17921354
esv34928 CNV Gain 17911159
nsv831741 CNV Loss 17160897
nsv517936 CNV Loss 19592680
nsv893990 CNV Loss 21882294
nsv893991 CNV Loss 21882294
nsv831742 CNV Loss 17160897
nsv438114 CNV Loss 16468122
nsv466603 CNV Loss 19166990
dgv8313n71 CNV Loss 21882294
dgv8314n71 CNV Loss 21882294
dgv8315n71 CNV Loss 21882294
nsv894005 CNV Loss 21882294
nsv8574 CNV Gain 18304495
nsv894006 CNV Gain 21882294

Relevant External Links for UCK1 Gene

HapMap Linkage Disequilibrium report
UCK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCK1 Gene

Disorders for UCK1 Gene

(1) Novoseek inferred disease relationships for UCK1 Gene

Disease -log(P) Hits PubMed IDs
cancer 0.79 2
genes like me logo Genes that share disorders with UCK1: view

No data available for UniProtKB/Swiss-Prot for UCK1 Gene

Publications for UCK1 Gene

  1. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. (PMID: 11306702) Van Rompay A.R. … Karlsson A. (Mol. Pharmacol. 2001) 2 3 4 23
  2. Human uridine-cytidine kinase phosphorylation of ribavirin: a convenient method for activation of ribavirin for conjugation to proteins. (PMID: 18080217) Virovic Jukic L. … Wu G.Y. (J. Biomed. Sci. 2008) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for UCK1 Gene

Sources for UCK1 Gene

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