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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UCHL5 Gene

protein-coding GIFtS: 59
GCID: GC01M192984

ubiquitin carboxyl-terminal hydrolase L5

Explore 7 diseases affiliated with
UCHL5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ubiquitin Carboxyl-Terminal Hydrolase L5¹ ²		UCH-L5² ³
UCH37¹ ² ³ ⁵		EC 3.4.19.12³ ⁸
CGI-70¹ ²		INO80 Complex Subunit R²
INO80R¹ ²		Ubiquitin Carboxyl-Terminal Esterase L5²
Ubiquitin C-Terminal Hydrolase UCH37² ³		Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L5²
Ubiquitin Thioesterase L5² ³

External Ids:	HGNC: 19678¹	Entrez Gene: 51377²	Ensembl: ENSG00000116750⁷	OMIM: 610667⁵	UniProtKB: Q9Y5K5³

ORGUL members:
	NONCODE:n410462

Export aliases for UCHL5 gene to outside databases

Previous GC identifers: GC01M188499 GC01M189450 GC01M190273 GC01M189716 GC01M191251 GC01M164220

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UCHL5_HUMAN, Q9Y5K5

Function: Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated

with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is

inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via

ADRM1

Gene Wiki entry for UCHL5 (Ubiquitin carboxyl-terminal hydrolase L5)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UCHL5 gene promoter:
Max1 Pax-6 IRF-1 AP-2gamma FOXJ2 (long isoform) AP-2beta FOXJ2 AP-2alpha c-Myc AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UCHL5 promoter sequence

Search SABiosciences Chromatin IP Primers for UCHL5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCHL5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q31.2 HGNC cytogenetic band: 1q32

UCHL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCHL5 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M192984: view genomic region (about GC identifiers)

Start:	192,984,889 bp from pter	End:	193,029,237 bp from pter
Size:	44,349 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UCHL5_HUMAN, Q9Y5K5 (See protein sequence)

Recommended Name: Ubiquitin carboxyl-terminal hydrolase isozyme L5

Size: 329 amino acids; 37607 Da

Subunit: Component of the 19S (PA700) regulatory complex of the 26S proteasome. Interacts with ADRM1 and NFRKB; in

vitro ADRM1 and NFRKB compete for interaction with UCHL5. Component of the INO80 complex; specifically part of a

complex module associated with N-terminus of INO80

Subcellular location: Cytoplasm. Nucleus. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates

with the INO80 complex in the nucleus

5 PDB 3D structures from and Proteopedia for UCHL5:

3A7S (3D)

3IHR (3D)

3RII (3D)

3RIS (3D)

3TB3 (3D)

Secondary accessions: Q5LJA6 Q5LJA7 Q8TBS4 Q96BJ9 Q9H1W5 Q9P0I3 Q9UQN2

Alternative splicing: 4 isoforms: Q9Y5K5-1 Q9Y5K5-2 Q9Y5K5-3 Q9Y5K5-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UCHL5: NX_Q9Y5K5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y5K5

4/6 DME Specific Peptides for UCHL5 (Q9Y5K5) (see all 6)

ENIRRKHN

QKYSEGEI

ESDPGVFTE

LSAIQSEVA

UCHL5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001186190.1 NP_001186191.1 NP_001186192.1 NP_057068.1

ENSEMBL proteins:

ENSP00000408720 ENSP00000356425 ENSP00000356424 ENSP00000402847 ENSP00000356420

ENSP00000356421 ENSP00000356418 ENSP00000356419 ENSP00000391153 ENSP00000392416

ENSP00000389563 ENSP00000412265 ENSP00000356422 ENSP00000431171

Reactome Protein details: Q9Y5K5
Human Recombinant Protein Products for UCHL5:

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	ProSpec Recombinant Protein for UCHL5
	Uscn Proteins for UCHL5

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	IEA	--
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	IDA	18922472

UCHL5 for ontologies About GeneDecksing

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	Uscn Antibodies for UCHL5
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	Uscn ELISAs and CLIAs for UCHL5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UCHL5 for domains About GeneDecksing

2 InterPro domains/families:

IPR001578 Peptidase_C12

IPR017390 Ubiquitinyl_hydrolase_UCH37

Graphical View of Domain Structure for InterPro Entry Q9Y5K5

ProtoNet protein and cluster: Q9Y5K5

1 Blocks protein family: IPB001578 Ubiquitin carboxyl-terminal hydrolase

UniProtKB/Swiss-Prot: UCHL5_HUMAN, Q9Y5K5

Similarity: Belongs to the peptidase C12 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: UCHL5_HUMAN, Q9Y5K5

Function: Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated

with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is

inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via

ADRM1

Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the

C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

Enzyme regulation: Activated by ADRM1. Inhibited by interaction with NFRKB

Enzyme Number (IUBMB): EC 3.4.19.12¹ ²

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004221	ubiquitin thiolesterase activity	IEA	--
GO:0004843	ubiquitin-specific protease activity	IDA	18922472
GO:0004866	endopeptidase inhibitor activity	IMP	18162577
GO:0005515	protein binding	IPI	--
GO:0008242	omega peptidase activity	IEA	--

UCHL5 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for UCHL5:

Decreased Salmonella enterica

Synthetic lethal with Ras

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Uchl5):

cellular

embryogenesis

growth/size

mortality/aging

nervous system

UCHL5 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for UCHL5

miRNA Products:		OriGene 3'-UTR Clone: UCHL5 Browse MicroRNA Expression Plasmids
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		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate UCHL5 (see all 48):
		hsa-miR-21* hsa-miR-607 hsa-let-7d hsa-miR-4328 hsa-miR-192 hsa-miR-570 hsa-miR-502-3p hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: UCHL5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UCHL5 (see all 7) OriGene shRNA RFP: UCHL5 OriGene siRNA: UCHL5
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCHL5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TGF-beta receptor signaling activates SMADs

TGF-beta receptor signaling activates SMADs

1.00

Downregulation of TGF-beta receptor signaling

0.90

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

Signaling by TGF-beta Receptor Complex

0.61

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for UCHL5

	Signaling by TGF-beta Receptor Complex
	TGF-beta receptor signaling activates SMADs
	Signal Transduction
	Downregulation of TGF-beta receptor signaling

UCHL5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for UCHL5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/910 Interacting proteins for UCHL5 (Q9Y5K5^{1, 2, 3} ENSP00000356425⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 910)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADRM1	Q16186¹^,²^,³, ENSP00000253003⁴	EBI-1051183,EBI-954387 MINT-3373742 MINT-4050637 MINT-4050597 MINT-4050618 MINT-3373565 MINT-4050661 MINT-4050722 MINT-3373718 MINT-3373835 MINT-3373811 I2D: score=5 STRING: ENSP00000253003
HIST1H4A	P62805³, ENSP00000352980⁴	I2D: score=14 STRING: ENSP00000352980
HIST1H4C	P62805³, ENSP00000367034⁴	I2D: score=14 STRING: ENSP00000367034
HIST1H4D	P62805³, ENSP00000343282⁴	I2D: score=14 STRING: ENSP00000343282
HIST1H4E	P62805³, ENSP00000353624⁴	I2D: score=14 STRING: ENSP00000353624

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006281	DNA repair	IEA	--
GO:0006310	DNA recombination	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006511	ubiquitin-dependent protein catabolic process	IEA	--

UCHL5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UCHL5
Search CenterWatch for drugs/clinical trials and news about UCHL5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UCHL5 gene (4 alternative transcripts):

NM_001199261.1 NM_001199262.1 NM_001199263.1 NM_015984.3

Unigene Cluster for UCHL5:

Ubiquitin carboxyl-terminal hydrolase L5

Hs.145469 [show with all ESTs]

Unigene Representative Sequence: NM_015984

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000420791 ENST00000367455(uc001gsm.3 uc001gsn.3) ENST00000367454(uc001gso.3 uc010pov.2)

ENST00000449480 ENST00000367450 ENST00000367451 ENST00000367448(uc001gsp.3)

ENST00000367449(uc001gsq.3) ENST00000443327 ENST00000416915 ENST00000421683

ENST00000483156 ENST00000417752 ENST00000367452(uc010pow.1) ENST00000530098(uc010pox.2)

miRNA Products:		OriGene 3'-UTR Clone: UCHL5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UCHL5
		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate UCHL5 (see all 48):
		hsa-miR-21* hsa-miR-607 hsa-let-7d hsa-miR-4328 hsa-miR-192 hsa-miR-570 hsa-miR-502-3p hsa-let-7g

		SwitchGear 3'UTR luciferase reporter plasmid: UCHL5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AF147717.1 AF151828.1 AF157320.1 AK024751.1 AK123655.1 AK225794.1 AK296487.1 AK301381.1

AK314445.1 AK316064.1 BC015381.1 BC015521.1 BC025369.2 BT006790.1 NR_037607.1

19 DOTS entries:

DT.413192 DT.100852894 DT.451993 DT.100802792 DT.95271248 DT.100657698 DT.92031871 DT.92066219

DT.121333259 DT.121333263 DT.121333266 DT.121333335 DT.442349 DT.75106208 DT.95271250 DT.95356535

DT.121333232 DT.75158724 DT.95247667

24/196 AceView cDNA sequences (see all 196):

AA553729 BC025369 BU194202 CK903489 BM677570 AA453326 BM771289 CB155982

BX111590 AI278259 BP354222 BM739400 AI146990 CB126041 BQ068400 AI374774

CB161772 BE910315 AL558259 BX484791 CK903488 AI674158 BQ923828 AA814801

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for UCHL5 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	·	15c	·	15d
SP1:															-		-												-
SP2:															-		-												-								-
SP3:															-		-												-								-		-		-
SP4:															-		-												-								-		-		-
SP5:																																					-		-		-

ECgene alternative splicing isoforms for UCHL5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UCHL5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

UCHL5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See UCHL5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UCHL5

SOURCE GeneReport for Unigene cluster: Hs.145469

SABiosciences Custom PCR Arrays for UCHL5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UCHL5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCHL5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCHL5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCHL5 gene from 9/35 species (see all 35) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	UCHL5¹	ubiquitin carboxyl-terminal hydrolase L5	84.82(n) 93.84(a)		424359 NM_001006530.1 NP_001006530.1
lizard (Anolis carolinensis)	Reptilia	UCHL5⁶	--	94(a)	1 ↔ 1	GL343267.1(1246907-1267890)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX761416.1²	--	78.89(n)		BX761416.1
zebrafish (Danio rerio)	Actinopterygii	uchl5¹	ubiquitin carboxyl-terminal hydrolase L5	74.67(n) 88.75(a)		406357 NM_213084.1 NP_998249.1
fruit fly (Drosophila melanogaster)	Insecta	Uch-L3¹	Ubiquitin C-terminal hydrolase	59.01(n) 62.58(a)		39102 NM_079279.2 NP_524003.1
worm (Caenorhabditis elegans)	Secernentea	ubh-4¹	Protein UBH-4	53.85(n) 48.86(a)		174289 NM_063283.3 NP_495684.2
A. gossypii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_AGL316W¹	AGL316Wp	45.82(n) 37.09(a)		4622644 NM_211413.1 NP_986351.1
thale cress (Arabidopsis thaliana)	eudicotyledons	UCH2¹	ubiquitin carboxyl-terminal hydrolase L5	55.74(n) 51.95(a)		842876 NM_105238.2 NP_564858.1
rice (Oryza sativa)	Liliopsida	AK104700.1²	--	74.2(n)		AK104700.1

ENSEMBL Gene Tree for UCHL5 (if available)
TreeFam Gene Tree for UCHL5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for UCHL5 gene

BAP1²

1 SIMAP similar gene for UCHL5 using alignment to 11 protein entries: UCHL5_HUMAN (see all proteins):

BAP1

UCHL5 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for UCHL5
PGOHUM00000259758

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145191489^1,2		--	192981137(+)	`GTCTTC/TTGGGT`	2	--	ds500¹		0	--	--	--	--
rs201829981^1,2	C	--	192981182(+)	`CAGCTA/TTNNNN`	2	--	ds500¹		0	--	--	--	--
rs181007504^1,2		--	192981337(+)	`GGCGGC/GGGACA`	2	--	ds500¹		0	--	--	--	--
rs148723927^1,2		--	192981366(+)	`AAATAC/TACCTA`	2	--	ds500¹		0	--	--	--	--
rs186387623^1,2		--	192981400(+)	`TATGGC/TTTATT`	2	--	ds500¹		0	--	--	--	--
rs56199152^1,2	C	--	192981433(+)	`CAAGAA/GAGAAT`	2	--	ds500¹		2		WA	120
rs191145462^1,2		--	192981539(+)	`TCATAC/TTGACA`	2	--	ut3¹		0	--	--	--	--
rs183551765^1,2		--	192981575(+)	`CATCAA/GACATG`	2	--	ut3¹		0	--	--	--	--
rs186810505^1,2		--	192981577(+)	`TCAAAC/GATGAT`	2	--	ut3¹		0	--	--	--	--
rs114475654^1,2		--	192981655(+)	`CAGTGT/CTAGTT`	2	--	ut3¹		1		NA	120

HapMap Linkage Disequilibrium report for UCHL5 (192984889 - 193029237 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UCHL5
1 CNV: 34745

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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UCHL5 for disorders           About GeneDecksing

OMIM gene information: 610667    OMIM disorders: --

7 diseases for UCHL5:    About MalaCards

sipple syndrome parathyroid carcinoma cervical carcinoma hepatocellular carcinoma

cervicitis carcinoma malaria

Export disorders for UCHL5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for UCHL5 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with UCHL5)

Utopia: connect your pdf to the dynamic
world of online information

Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2, 3} Lai C.H....Lin W. (2000)
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. (PubMed id 16906146)^{1, 2, 9} Yao T.... Cohen R.E. (2006)
The deubiquitinating enzyme UCH37 interacts with Smad s and regulates TGF-beta signalling. (PubMed id 16027725)^{1, 3, 9} Wicks S.J....Chantry A. (2005)
Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)^{1, 2} Chen L.... Conaway R.C. (2011)
Crystal structure of the de-ubiquitinating enzyme UCH 37 (human UCH-L5) catalytic domain. (PubMed id 19836345)^{1, 2} Nishio K....Morimoto Y. (2009)
Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)^{1, 2} Yao T....Conaway J.W. (2008)
hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. (PubMed id 17139257)^{1, 2} Qiu X.-B.... Goldberg A.L. (2006)
A novel proteasome-interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. (PubMed id 16990800)^{1, 2} Hamazaki J....Murata S. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51377	HGNC: 19678	AceView: UCHL5	Ensembl:ENSG00000116750	euGenes: HUgn51377
ECgene: UCHL5	H-InvDB: UCHL5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for UCHL5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UCHL5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for UCHL5 gene:
Search GeneIP for patents involving UCHL5

GeneCards and IP:
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UCHL5 Gene

ubiquitin carboxyl-terminal hydrolase L5

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UCHL5 Gene

ubiquitin carboxyl-terminal hydrolase L5

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