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Aliases for UCHL5 Gene

Aliases for UCHL5 Gene

  • Ubiquitin C-Terminal Hydrolase L5 2 3 5
  • Ubiquitin Carboxyl-Terminal Hydrolase L5 2 3
  • Ubiquitin C-Terminal Hydrolase UCH37 3 4
  • Ubiquitin Thioesterase L5 3 4
  • INO80 Complex Subunit R 2 3
  • EC 3.4.19.12 4 63
  • UCH-L5 3 4
  • UCH37 3 4
  • Ubiquitin Carboxyl-Terminal Esterase L5 3
  • CGI-70 3
  • INO80R 3

External Ids for UCHL5 Gene

Previous GeneCards Identifiers for UCHL5 Gene

  • GC01M188499
  • GC01M189450
  • GC01M190273
  • GC01M189716
  • GC01M191251
  • GC01M164220

Summaries for UCHL5 Gene

GeneCards Summary for UCHL5 Gene

UCHL5 (Ubiquitin C-Terminal Hydrolase L5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. GO annotations related to this gene include poly(A) RNA binding and endopeptidase inhibitor activity. An important paralog of this gene is BAP1.

UniProtKB/Swiss-Prot for UCHL5 Gene

  • Protease that specifically cleaves Lys-48-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Gene Wiki entry for UCHL5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCHL5 Gene

Genomics for UCHL5 Gene

Regulatory Elements for UCHL5 Gene

Promoters for UCHL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UCHL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for UCHL5 Gene

Chromosome:
1
Start:
193,012,250 bp from pter
End:
193,060,107 bp from pter
Size:
47,858 bases
Orientation:
Minus strand

Genomic View for UCHL5 Gene

Genes around UCHL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCHL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCHL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCHL5 Gene

Proteins for UCHL5 Gene

  • Protein details for UCHL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5K5-UCHL5_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase isozyme L5
    Protein Accession:
    Q9Y5K5
    Secondary Accessions:
    • Q5LJA6
    • Q5LJA7
    • Q8TBS4
    • Q96BJ9
    • Q9H1W5
    • Q9P0I3
    • Q9UQN2

    Protein attributes for UCHL5 Gene

    Size:
    329 amino acids
    Molecular mass:
    37607 Da
    Quaternary structure:
    • Component of the 19S (PA700) regulatory complex of the 26S proteasome. Interacts with ADRM1 and NFRKB; in vitro ADRM1 and NFRKB compete for interaction with UCHL5. Component of the INO80 complex; specifically part of a complex module associated with N-terminus of INO80.

    Three dimensional structures from OCA and Proteopedia for UCHL5 Gene

    Alternative splice isoforms for UCHL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UCHL5 Gene

Proteomics data for UCHL5 Gene at MOPED

Selected DME Specific Peptides for UCHL5 Gene

Post-translational modifications for UCHL5 Gene

  • Ubiquitination at Lys 47, Lys 154, Lys 158, Lys 206, Lys 210, Lys 234, Lys 277, Lys 282, and Lys 315
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for UCHL5

Domains & Families for UCHL5 Gene

Gene Families for UCHL5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5K5

UniProtKB/Swiss-Prot:

UCHL5_HUMAN :
  • Belongs to the peptidase C12 family.
Family:
  • Belongs to the peptidase C12 family.
genes like me logo Genes that share domains with UCHL5: view

Function for UCHL5 Gene

Molecular function for UCHL5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by ADRM1. Inhibited by interaction with NFRKB.
UniProtKB/Swiss-Prot Function:
Protease that specifically cleaves Lys-48-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Enzyme Numbers (IUBMB) for UCHL5 Gene

Gene Ontology (GO) - Molecular Function for UCHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008242 omega peptidase activity IEA --
GO:0070628 proteasome binding IDA 18162577
genes like me logo Genes that share ontologies with UCHL5: view
genes like me logo Genes that share phenotypes with UCHL5: view

Animal Models for UCHL5 Gene

MGI Knock Outs for UCHL5:

Animal Model Products

  • Taconic Biosciences Mouse Models for UCHL5

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UCHL5 Gene

Localization for UCHL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCHL5 Gene

Cytoplasm. Nucleus. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCHL5 Gene COMPARTMENTS Subcellular localization image for UCHL5 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UCHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with UCHL5: view

Pathways & Interactions for UCHL5 Gene

genes like me logo Genes that share pathways with UCHL5: view

SIGNOR curated interactions for UCHL5 Gene

Activates:

Gene Ontology (GO) - Biological Process for UCHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0021670 lateral ventricle development IEA --
GO:0030901 midbrain development IEA --
GO:0061136 regulation of proteasomal protein catabolic process IMP 18162577
genes like me logo Genes that share ontologies with UCHL5: view

Drugs & Compounds for UCHL5 Gene

(1) Drugs for UCHL5 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
WP1130 Pharma Deubiquitinase (DUB) inhibitor, Cell permeable 0

(1) ApexBio Compounds for UCHL5 Gene

Compound Action Cas Number
WP1130 Deubiquitinase (DUB) inhibitor, Cell permeable 856243-80-6
genes like me logo Genes that share compounds with UCHL5: view

Transcripts for UCHL5 Gene

Unigene Clusters for UCHL5 Gene

Ubiquitin carboxyl-terminal hydrolase L5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCHL5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - - - - - -
SP7: - - -
SP8: -
SP9:

Relevant External Links for UCHL5 Gene

GeneLoc Exon Structure for
UCHL5
ECgene alternative splicing isoforms for
UCHL5

Expression for UCHL5 Gene

mRNA expression in normal human tissues for UCHL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UCHL5 Gene

This gene is overexpressed in Skin (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UCHL5 Gene



SOURCE GeneReport for Unigene cluster for UCHL5 Gene Hs.145469

genes like me logo Genes that share expression patterns with UCHL5: view

Protein tissue co-expression partners for UCHL5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UCHL5 Gene

Orthologs for UCHL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCHL5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UCHL5 35
  • 94.51 (n)
  • 98.48 (a)
UCHL5 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCHL5 35
  • 94.83 (n)
  • 99.39 (a)
UCHL5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uchl5 35
  • 90.88 (n)
  • 96.96 (a)
Uchl5 16
Uchl5 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UCHL5 35
  • 99.89 (n)
  • 99.68 (a)
UCHL5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uchl5 35
  • 92.17 (n)
  • 97.46 (a)
oppossum
(Monodelphis domestica)
Mammalia UCHL5 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UCHL5 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves UCHL5 35
  • 84.82 (n)
  • 93.84 (a)
UCHL5 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UCHL5 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uchl5 35
  • 78.42 (n)
  • 85.41 (a)
zebrafish
(Danio rerio)
Actinopterygii uchl5 35
  • 74.67 (n)
  • 88.75 (a)
uchl5 36
  • 88 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005540 35
  • 59.77 (n)
  • 65.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta Uch-L3 35
  • 59.12 (n)
  • 62.58 (a)
CG1950 36
  • 47 (a)
OneToMany
Uch-L3 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubh-4 35
  • 54.69 (n)
  • 50.17 (a)
ubh-4 36
  • 46 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons UCH2 35
  • 55.52 (n)
  • 52.6 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1514 35
rice
(Oryza sativa)
Liliopsida Os02g0822200 35
  • 56.26 (n)
  • 51.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4974 36
  • 57 (a)
OneToOne
Species with no ortholog for UCHL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UCHL5 Gene

ENSEMBL:
Gene Tree for UCHL5 (if available)
TreeFam:
Gene Tree for UCHL5 (if available)

Paralogs for UCHL5 Gene

Paralogs for UCHL5 Gene

Pseudogenes.org Pseudogenes for UCHL5 Gene

genes like me logo Genes that share paralogs with UCHL5: view

Variants for UCHL5 Gene

Sequence variations from dbSNP and Humsavar for UCHL5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_011613 -
rs10907 -- 193,015,688(+) TTGAA(C/G)CATAA nc-transcript-variant, utr-variant-3-prime
rs718260 -- 193,021,956(-) AGTTT(A/C)CATAA intron-variant
rs1062999 -- 193,012,732(-) ACTTT(C/T)CAAAT nc-transcript-variant, utr-variant-3-prime
rs1323000 -- 193,043,770(-) acccc(A/C)tccga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UCHL5 Gene

Variant ID Type Subtype PubMed ID
nsv466994 CNV Loss 19166990
nsv498699 CNV Loss 21111241
nsv3966 CNV Loss 18451855

Variation tolerance for UCHL5 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UCHL5 Gene

HapMap Linkage Disequilibrium report
UCHL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCHL5 Gene

Disorders for UCHL5 Gene

Relevant External Links for UCHL5

Genetic Association Database (GAD)
UCHL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UCHL5

No disorders were found for UCHL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UCHL5 Gene

Publications for UCHL5 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling. (PMID: 16027725) Wicks S.J. … Chantry A. (Oncogene 2005) 2 3 23
  3. Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. (PMID: 16906146) Yao T. … Cohen R.E. (Nat. Cell Biol. 2006) 3 23
  4. The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13. (PMID: 25666615) Aguileta M.A. … Husnjak K. (J. Biol. Chem. 2015) 3
  5. Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G. (PMID: 25702870) Sahtoe D.D. … Sixma T.K. (Mol. Cell 2015) 3

Products for UCHL5 Gene

Sources for UCHL5 Gene

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