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Aliases for UCHL5 Gene

Aliases for UCHL5 Gene

  • Ubiquitin Carboxyl-Terminal Hydrolase L5 2 3
  • UCH37 3 4 6
  • Ubiquitin C-Terminal Hydrolase UCH37 3 4
  • Ubiquitin Thioesterase L5 3 4
  • INO80 Complex Subunit R 2 3
  • EC 3.4.19.12 4 63
  • UCH-L5 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L5 3
  • Ubiquitin Carboxyl-Terminal Esterase L5 3
  • CGI-70 3
  • INO80R 3

External Ids for UCHL5 Gene

Previous GeneCards Identifiers for UCHL5 Gene

  • GC01M188499
  • GC01M189450
  • GC01M190273
  • GC01M189716
  • GC01M191251
  • GC01M164220

Summaries for UCHL5 Gene

GeneCards Summary for UCHL5 Gene

UCHL5 (Ubiquitin Carboxyl-Terminal Hydrolase L5) is a Protein Coding gene. Diseases associated with UCHL5 include cannabis dependence. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include ubiquitin thiolesterase activity and endopeptidase inhibitor activity. An important paralog of this gene is BAP1.

UniProtKB/Swiss-Prot for UCHL5 Gene

  • Protease that specifically cleaves Lys-48-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Gene Wiki entry for UCHL5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCHL5 Gene

Genomics for UCHL5 Gene

Regulatory Elements for UCHL5 Gene

Genomic Location for UCHL5 Gene

Start:
193,012,250 bp from pter
End:
193,060,107 bp from pter
Size:
47,858 bases
Orientation:
Minus strand

Genomic View for UCHL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UCHL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCHL5 Gene

Proteins for UCHL5 Gene

  • Protein details for UCHL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5K5-UCHL5_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase isozyme L5
    Protein Accession:
    Q9Y5K5
    Secondary Accessions:
    • Q5LJA6
    • Q5LJA7
    • Q8TBS4
    • Q96BJ9
    • Q9H1W5
    • Q9P0I3
    • Q9UQN2

    Protein attributes for UCHL5 Gene

    Size:
    329 amino acids
    Molecular mass:
    37607 Da
    Quaternary structure:
    • Component of the 19S (PA700) regulatory complex of the 26S proteasome. Interacts with ADRM1 and NFRKB; in vitro ADRM1 and NFRKB compete for interaction with UCHL5. Component of the INO80 complex; specifically part of a complex module associated with N-terminus of INO80.

    Three dimensional structures from OCA and Proteopedia for UCHL5 Gene

    Alternative splice isoforms for UCHL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UCHL5 Gene

Proteomics data for UCHL5 Gene at MOPED

Selected DME Specific Peptides for UCHL5 Gene

Post-translational modifications for UCHL5 Gene

  • Ubiquitination at Lys47, Lys154, Lys158, Lys206, Lys210, Lys234, Lys277, Lys282, and Lys315
  • Modification sites at PhosphoSitePlus

Domains for UCHL5 Gene

Gene Families for UCHL5 Gene

HGNC:
  • INO80 :INO80 complex subunits

Graphical View of Domain Structure for InterPro Entry

Q9Y5K5

UniProtKB/Swiss-Prot:

UCHL5_HUMAN :
  • Q9Y5K5
Family:
  • Belongs to the peptidase C12 family.
genes like me logo Genes that share domains with UCHL5: view

Function for UCHL5 Gene

Molecular function for UCHL5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by ADRM1. Inhibited by interaction with NFRKB.
UniProtKB/Swiss-Prot Function: Protease that specifically cleaves Lys-48-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Enzyme Numbers (IUBMB) for UCHL5 Gene

Gene Ontology (GO) - Molecular Function for UCHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 ubiquitin-specific protease activity IDA 18922472
GO:0004866 endopeptidase inhibitor activity IMP 18162577
GO:0005515 protein binding IPI 11163772
GO:0008242 omega peptidase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with UCHL5: view
genes like me logo Genes that share phenotypes with UCHL5: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UCHL5 Gene

Localization for UCHL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCHL5 Gene

Cytoplasm. Nucleus. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCHL5 Gene COMPARTMENTS Subcellular localization image for UCHL5 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UCHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 18922472
GO:0005829 cytosol IDA 18922472
GO:0031011 colocalizes_with Ino80 complex IDA 18922472
genes like me logo Genes that share ontologies with UCHL5: view

Pathways for UCHL5 Gene

genes like me logo Genes that share pathways with UCHL5: view

Gene Ontology (GO) - Biological Process for UCHL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with UCHL5: view

Transcripts for UCHL5 Gene

Unigene Clusters for UCHL5 Gene

Ubiquitin carboxyl-terminal hydrolase L5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCHL5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - - - - - -
SP7: - - -
SP8: -
SP9:

Relevant External Links for UCHL5 Gene

GeneLoc Exon Structure for
UCHL5
ECgene alternative splicing isoforms for
UCHL5

Expression for UCHL5 Gene

mRNA expression in normal human tissues for UCHL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UCHL5 Gene

SOURCE GeneReport for Unigene cluster for UCHL5 Gene Hs.145469

genes like me logo Genes that share expressions with UCHL5: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UCHL5 Gene

Orthologs for UCHL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCHL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UCHL5 35
  • 99.89 (n)
  • 99.68 (a)
UCHL5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UCHL5 35
  • 94.51 (n)
  • 98.48 (a)
UCHL5 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCHL5 35
  • 94.83 (n)
  • 99.39 (a)
UCHL5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uchl5 35
  • 90.88 (n)
  • 96.96 (a)
Uchl5 16
Uchl5 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UCHL5 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UCHL5 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uchl5 35
  • 92.17 (n)
  • 97.46 (a)
chicken
(Gallus gallus)
Aves UCHL5 35
  • 84.82 (n)
  • 93.84 (a)
UCHL5 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UCHL5 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uchl5 35
  • 78.42 (n)
  • 85.41 (a)
zebrafish
(Danio rerio)
Actinopterygii uchl5 35
  • 74.67 (n)
  • 88.75 (a)
uchl5 36
  • 88 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005540 35
  • 59.77 (n)
  • 65.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1950 36
  • 47 (a)
OneToMany
Uch-L3 35
  • 59.12 (n)
  • 62.58 (a)
Uch-L3 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubh-4 35
  • 54.69 (n)
  • 50.17 (a)
ubh-4 36
  • 46 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1514 35
thale cress
(Arabidopsis thaliana)
eudicotyledons UCH2 35
  • 55.52 (n)
  • 52.6 (a)
rice
(Oryza sativa)
Liliopsida Os02g0822200 35
  • 56.26 (n)
  • 51.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4974 36
  • 57 (a)
OneToOne
Species with no ortholog for UCHL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UCHL5 Gene

ENSEMBL:
Gene Tree for UCHL5 (if available)
TreeFam:
Gene Tree for UCHL5 (if available)

Paralogs for UCHL5 Gene

Paralogs for UCHL5 Gene

Pseudogenes.org Pseudogenes for UCHL5 Gene

genes like me logo Genes that share paralogs with UCHL5: view

Variants for UCHL5 Gene

Sequence variations from dbSNP and Humsavar for UCHL5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10907 -- 193,015,688(+) TTGAA(C/G)CATAA utr-variant-3-prime
rs718260 -- 193,021,956(-) AGTTT(A/C)CATAA intron-variant
rs1062999 -- 193,012,732(-) ACTTT(C/T)CAAAT utr-variant-3-prime
rs1323000 -- 193,043,770(-) acccc(A/C)tccga intron-variant
rs1555555 -- 193,045,932(-) ATCTA(C/G)GTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UCHL5 Gene

Variant ID Type Subtype PubMed ID
nsv466994 CNV Loss 19166990
nsv498699 CNV Loss 21111241
nsv3966 CNV Loss 18451855

Relevant External Links for UCHL5 Gene

HapMap Linkage Disequilibrium report
UCHL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCHL5 Gene

Disorders for UCHL5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for UCHL5 Gene including...

Search for UCHL5 Gene in MalaCards »

Relevant External Links for UCHL5

Genetic Association Database (GAD)
UCHL5
genes like me logo Genes that share disorders with UCHL5: view

No data available for UniProtKB/Swiss-Prot for UCHL5 Gene

Publications for UCHL5 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling. (PMID: 16027725) Wicks S.J. … Chantry A. (Oncogene 2005) 2 3 23
  3. Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. (PMID: 16906146) Yao T. … Cohen R.E. (Nat. Cell Biol. 2006) 3 4 23
  4. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T. … Conaway J.W. (Mol. Cell 2008) 3 4
  5. Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH- L5) catalytic domain. (PMID: 19836345) Nishio K. … Morimoto Y. (Biochem. Biophys. Res. Commun. 2009) 3 4

Products for UCHL5 Gene

  • Addgene plasmids for UCHL5

Sources for UCHL5 Gene

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