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Aliases for UCHL3 Gene

Aliases for UCHL3 Gene

  • Ubiquitin Carboxyl-Terminal Esterase L3 (Ubiquitin Thiolesterase) 2 3
  • Ubiquitin Thioesterase L3 3 4
  • UCH-L3 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 3
  • Ubiquitin Thiolesterase 3
  • EC 3.4.19.12 4

External Ids for UCHL3 Gene

Summaries for UCHL3 Gene

Entrez Gene Summary for UCHL3 Gene

  • The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GeneCards Summary for UCHL3 Gene

UCHL3 (Ubiquitin Carboxyl-Terminal Esterase L3 (Ubiquitin Thiolesterase)) is a Protein Coding gene. Among its related pathways are Protein Stability and Neuroscience. GO annotations related to this gene include ubiquitin thiolesterase activity and peptidase activity. An important paralog of this gene is UCHL1.

UniProtKB/Swiss-Prot for UCHL3 Gene

  • Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards Lys-48-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.

Gene Wiki entry for UCHL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCHL3 Gene

Genomics for UCHL3 Gene

Genomic Location for UCHL3 Gene

Start:
75,549,480 bp from pter
End:
75,606,020 bp from pter
Size:
56,541 bases
Orientation:
Plus strand

Genomic View for UCHL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UCHL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCHL3 Gene

Regulatory Elements for UCHL3 Gene

Proteins for UCHL3 Gene

  • Protein details for UCHL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15374-UCHL3_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase isozyme L3
    Protein Accession:
    P15374
    Secondary Accessions:
    • B2R970
    • Q5TBK8
    • Q6IBE9

    Protein attributes for UCHL3 Gene

    Size:
    230 amino acids
    Molecular mass:
    26183 Da
    Quaternary structure:
    • Preferentially binds diubiquitin; the interaction does not hydrolyze diubiquitin but, in vitro, inhibits the hydrolyzing activity on other substrates.
    Miscellaneous:
    • Identified as a tumor-specific antigen in colon cancer

    Three dimensional structures from OCA and Proteopedia for UCHL3 Gene

neXtProt entry for UCHL3 Gene

Proteomics data for UCHL3 Gene at MOPED

Post-translational modifications for UCHL3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys121

Other Protein References for UCHL3 Gene

No data available for DME Specific Peptides for UCHL3 Gene

Domains for UCHL3 Gene

Protein Domains for UCHL3 Gene

UniProtKB/Swiss-Prot:

UCHL3_HUMAN
Family:
  • Belongs to the peptidase C12 family.:
    • P15374
genes like me logo Genes that share domains with UCHL3: view

No data available for Gene Families for UCHL3 Gene

Function for UCHL3 Gene

Molecular function for UCHL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by monoubiquitin and diubiquitin.
UniProtKB/Swiss-Prot Function: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards Lys-48-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.

Enzyme Numbers (IUBMB) for UCHL3 Gene

Gene Ontology (GO) - Molecular Function for UCHL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004221 ubiquitin thiolesterase activity --
GO:0004843 ubiquitin-specific protease activity IEA --
GO:0005515 protein binding IPI 21453705
GO:0008233 peptidase activity IDA 21762696
GO:0043130 ubiquitin binding IDA 19154770
genes like me logo Genes that share ontologies with UCHL3: view
genes like me logo Genes that share phenotypes with UCHL3: view

Animal Models for UCHL3 Gene

MGI Knock Outs for UCHL3:

miRNA for UCHL3 Gene

miRTarBase miRNAs that target UCHL3

No data available for Transcription Factor Targeting and HOMER Transcription for UCHL3 Gene

Localization for UCHL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCHL3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCHL3 Gene COMPARTMENTS Subcellular localization image for UCHL3 gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UCHL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with UCHL3: view

Pathways for UCHL3 Gene

genes like me logo Genes that share pathways with UCHL3: view

Pathways by source for UCHL3 Gene

2 Cell Signaling Technology pathways for UCHL3 Gene
1 BioSystems pathway for UCHL3 Gene

Gene Ontology (GO) - Biological Process for UCHL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0030163 protein catabolic process IDA 21762696
genes like me logo Genes that share ontologies with UCHL3: view

Compounds for UCHL3 Gene

(1) Novoseek inferred chemical compound relationships for UCHL3 Gene

Compound -log(P) Hits PubMed IDs
cysteine 10.5 1
genes like me logo Genes that share compounds with UCHL3: view

Transcripts for UCHL3 Gene

Unigene Clusters for UCHL3 Gene

Ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCHL3 Gene

No ASD Table

Relevant External Links for UCHL3 Gene

GeneLoc Exon Structure for
UCHL3
ECgene alternative splicing isoforms for
UCHL3

Expression for UCHL3 Gene

mRNA expression in normal human tissues for UCHL3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UCHL3 Gene

SOURCE GeneReport for Unigene cluster for UCHL3 Gene Hs.162241

mRNA Expression by UniProt/SwissProt for UCHL3 Gene

P15374-UCHL3_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, and testis.
genes like me logo Genes that share expressions with UCHL3: view

Orthologs for UCHL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCHL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UCHL3 36
  • 100 (n)
  • 100 (a)
UCHL3 37
  • 75 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UCHL3 36
  • 94.93 (n)
  • 99.13 (a)
UCHL3 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCHL3 36
  • 95.65 (n)
  • 100 (a)
UCHL3 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uchl3 36
  • 90.43 (n)
  • 98.26 (a)
Uchl3 16
Uchl3 37
  • 98 (a)
OneToMany
Uchl4 37
  • 94 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia UCHL3 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UCHL3 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uchl3 36
  • 88.7 (n)
  • 97.83 (a)
chicken
(Gallus gallus)
Aves UCHL3 36
  • 82.9 (n)
  • 86.09 (a)
UCHL3 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UCHL3 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uchl3 36
  • 74.93 (n)
  • 74.35 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3304 36
zebrafish
(Danio rerio)
Actinopterygii Dr.16889 36
uchl3 36
  • 68.41 (n)
  • 74.35 (a)
uchl3 37
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012113 36
  • 50.68 (n)
  • 49.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta Uch 36
  • 55.11 (n)
  • 51.35 (a)
Uch 37
  • 49 (a)
OneToMany
Uch 38
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea ubh-1 37
  • 41 (a)
ManyToMany
ubh-2 37
  • 31 (a)
ManyToMany
ubh-3 37
  • 37 (a)
ManyToMany
F46E10.8 38
  • 40 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL314C 36
  • 49.59 (n)
  • 38.81 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YUH1 36
  • 49.33 (n)
  • 40.46 (a)
YUH1 37
  • 31 (a)
OneToMany
YUH1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E09967g 36
  • 51.36 (n)
  • 41.28 (a)
soybean
(Glycine max)
eudicotyledons Gma.11207 36
thale cress
(Arabidopsis thaliana)
eudicotyledons UCH3 36
  • 55.91 (n)
  • 52.27 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.6337 36
rice
(Oryza sativa)
Liliopsida Os02g0654500 36
  • 52.82 (n)
  • 49.32 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06372 36
  • 45.93 (n)
  • 40 (a)
Species with no ortholog for UCHL3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UCHL3 Gene

ENSEMBL:
Gene Tree for UCHL3 (if available)
TreeFam:
Gene Tree for UCHL3 (if available)

Paralogs for UCHL3 Gene

Paralogs for UCHL3 Gene

Selected SIMAP similar genes for UCHL3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UCHL3: view

Variants for UCHL3 Gene

Sequence variations from dbSNP and Humsavar for UCHL3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs966058 -- 75,579,919(+) AGTTT(C/G)AGAAG intron-variant
rs966059 -- 75,580,214(+) CCAAC(C/T)GAACA intron-variant
rs972542 -- 75,587,064(+) taaaa(C/G)gtaga intron-variant
rs973122 -- 75,552,101(+) GTACA(C/T)TATAT intron-variant
rs974373 -- 75,589,660(+) TTTAC(A/G)TATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UCHL3 Gene

Variant ID Type Subtype PubMed ID
nsv521444 CNV Gain 19592680
nsv900562 CNV Loss 21882294
dgv1692n71 CNV Loss 21882294
nsv1090 CNV Insertion 18451855
dgv1693n71 CNV Loss 21882294
dgv1694n71 CNV Loss 21882294
dgv1695n71 CNV Loss 21882294
dgv1696n71 CNV Loss 21882294
esv2747671 CNV Deletion 23290073
esv2747672 CNV Deletion 23290073
esv2747673 CNV Deletion 23290073
nsv900578 CNV Loss 21882294
esv2751152 CNV Loss 17911159
esv259826 OTHER Complex 20981092

Relevant External Links for UCHL3 Gene

HapMap Linkage Disequilibrium report
UCHL3

Disorders for UCHL3 Gene

(1) Novoseek inferred disease relationships for UCHL3 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 5

Relevant External Links for UCHL3

Genetic Association Database (GAD)
UCHL3
Human Genome Epidemiology (HuGE) Navigator
UCHL3
genes like me logo Genes that share disorders with UCHL3: view

No data available for UniProtKB/Swiss-Prot for UCHL3 Gene

Publications for UCHL3 Gene

  1. Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8- A resolution. (PMID: 9233788) Johnston S.C. … Hill C.P. (EMBO J. 1997) 3 4 23
  2. Cleavage of the C-terminus of NEDD8 by UCH-L3. (PMID: 9790970) Wada H. … Kamitani T. (Biochem. Biophys. Res. Commun. 1998) 3 4 23
  3. Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C- terminal hydrolase L3. (PMID: 14595809) Nam M.J. … Hanash S.M. (Proteomics 2003) 3 4 23
  4. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. (PMID: 2530630) Wilkinson K.D. … Pohl J. (Science 1989) 2 3 4
  5. Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH- L3). (PMID: 21762696) Dennissen F.J. … van Leeuwen F.W. (FEBS Lett. 2011) 3 4

Products for UCHL3 Gene

  • Addgene plasmids for UCHL3

Sources for UCHL3 Gene

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