UCHL3 Gene
protein-coding GIFtS: 64
GCID: GC13P076123
|
|
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
| |
Aliases
for UCHL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Carboxyl-Terminal Esterase L3 (Ubiquitin Thiolesterase)1 2 | | Ubiquitin Thioesterase L32 3 | | UCH-L32 3 | | Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L32 | | Ubiquitin Thiolesterase2 | | EC 3.4.19.123 |
Export aliases for UCHL3 gene to outside databasesPrevious GC identifers: GC13P074091 GC13P070118 GC13P075060 GC13P073921 GC13P075021 GC13P056821 |
Summaries
for UCHL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UCHL3:
The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family areproteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on themechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins toregenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants thatencode different protein isoforms. (provided by RefSeq, Aug 2012)
UniProtKB/Swiss-Prot: UCHL3_HUMAN, P15374Function: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitinprecursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminalglycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits apreference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulatingapical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotesinsulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germcell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is noteffectively degraded by the proteasome and is associated with neurogenerative disorders
Gene Wiki entry for UCHL3
|
Genomic Views
for UCHL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UCHL3 gene promoter:
HOXA9 HOXA9B p53 Meis-1a Meis-1b Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for UCHL3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCHL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q22.2 Ensembl cytogenetic band: 13q22.2 HGNC cytogenetic band: 13q21.33UCHL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P076123: view genomic region
(about GC identifiers)
Start:
|
76,123,619 bp from pter |
End:
|
76,180,085 bp from pter |
Size:
|
56,467 bases |
Orientation:
|
plus strand |
|
Proteins
for UCHL3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UCHL3_HUMAN, P15374 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase isozyme L3 Size: 230 amino acids; 26183 Da
Subunit: Preferentially binds diubiquitin; the interaction does not hydrolyze diubiquitin but, in vitro, inhibits thehydrolyzing activity on other substrates
Subcellular location: Cytoplasm
Miscellaneous: Identified as a tumor-specific antigen in colon cancer
2 PDB 3D structures from  and Proteopedia  for UCHL3:1UCH (3D)
1XD3 (3D)
Secondary accessions: B2R970 Q5TBK8 Q6IBE9Explore the universe of human proteins at neXtProt for UCHL3: NX_P15374
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P15374
UCHL3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001257881.1 NP_005993.1
ENSEMBL proteins: ENSP00000366819 ENSP00000398189
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
UCHL3 for ontologies About GeneDecksing
UCHL3 Antibody Products:
Assay Products for UCHL3: |
Protein
Domains /
Families
for UCHL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UCHL3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P15374ProtoNet protein and cluster: P15374 1 Blocks protein family: IPB001578 Ubiquitin carboxyl-terminal hydrolase
UniProtKB/Swiss-Prot: UCHL3_HUMAN, P15374Similarity: Belongs to the peptidase C12 family |
Function
for UCHL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UCHL3_HUMAN, P15374Function: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitinprecursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminalglycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits apreference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulatingapical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotesinsulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germcell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is noteffectively degraded by the proteasome and is associated with neurogenerative disordersCatalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Enzyme regulation: Inhibited by monoubiquitin and diubiquitinEnzyme Number (IUBMB): EC 3.4.19.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UCHL3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UCHL3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for UCHL3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCHL3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCHL3 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
UCHL3 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for UCHL3:
Animal Models:
Mouse knock-out Uchl3tm1Tilg for UCHL3
11 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Uchl3):
UCHL3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for UCHL3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein Stability | | | 2 | Neuroscience | | | 3 | Ubiquitinated Orc1 is degraded by the proteasome | | | 4 | APC-Cdc20 mediated degradation of Nek2A | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for UCHL3
2 
Cell Signaling Technology (CST) Pathways for UCHL3
1  BioSystems Pathway for UCHL3
UCHL3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UCHL3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
17/37 Interacting proteins for UCHL3 (P153742, 3 ENSP000003668194) via UniProtKB, MINT, STRING, and/or I2D (see all 37) (see top 5)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ATXN7L3 | Q14CW92, 3, ENSP000003972594 | MINT-2863955 I2D:
score=3 STRING: ENSP00000397259 | | HMP19 | Q9Y3282, 3, ENSP000003077224 | MINT-8276684 I2D:
score=2 STRING: ENSP00000307722 | | POGK | Q9P2152, 3, ENSP000003568494 | MINT-8276695 I2D:
score=2 STRING: ENSP00000356849 | | SMAD1 | Q157972, 3, ENSP000003057694 | MINT-8149667 MINT-8149655 I2D:
score=3 STRING: ENSP00000305769 | | UBA52 | P629873, ENSP000003881074 | I2D:
score=3 STRING: ENSP00000388107 | | UBB | P0CG473, ENSP000003046974 | I2D:
score=3 STRING: ENSP00000304697 | | CLPB | Q9H0783, ENSP000002940534 | I2D:
score=2 STRING: ENSP00000294053 | | COPS5 | Q929053, ENSP000003505124 | I2D:
score=2 STRING: ENSP00000350512 | | USP20 | Q9Y2K63, ENSP000003138114 | I2D:
score=2 STRING: ENSP00000313811 | | PGD | P522093, ENSP000002707764 | I2D:
score=1 STRING: ENSP00000270776 | | UBC | P0CG483, ENSP000003448184 | I2D:
score=4 STRING: ENSP00000344818 | | COPS6 | Q7L5N13, ENSP000003041024 | I2D:
score=2 STRING: ENSP00000304102 | | NEDD8 | Q158433, ENSP000002504954 | I2D:
score=3 STRING: ENSP00000250495 | | RPS27A | P629793, ENSP000002723174 | I2D:
score=4 STRING: ENSP00000272317 | | UBA1 | P223143, ENSP000003384134 | I2D:
score=1 STRING: ENSP00000338413 | | ADA | P008133 | I2D:
score=1 | | ASF1A | Q9Y2943 | I2D:
score=1 |
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
NAS | -- | | GO:0030163 | protein catabolic process |
IDA | -- |
UCHL3 for ontologies About GeneDecksing
|
Drugs & Compounds
for UCHL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
UCHL3 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for UCHL3 |
 Browse Tocris compounds for UCHL3
1 Novoseek chemical compound relationship for UCHL3 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cysteine |
10.5 |
1 |
17449248 (1) |
Search CenterWatch for drugs/clinical trials and news about UCHL3
|
Transcripts
for UCHL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UCHL3 gene (2 alternative transcripts): NM_001270952.1 NM_006002.4 Unigene Cluster for UCHL3: Ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) Hs.162241 [show with all ESTs]Unigene Representative Sequence: BF2177443 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000471792 ENST00000377595(uc001vjq.3) ENST00000419068
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UCHL3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UCHL3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UCHL3 (NM_006002) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UCHL3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCHL3 |
Additional cDNA sequence: AK313665.1 BC018125.2 BT019359.1 CR456855.1 M30496.1 9 DOTS entries: DT.100020229 DT.443153 DT.100759696 DT.120775701 DT.92422609 DT.100759697 DT.120775606 DT.92422607 DT.314341 24/105 AceView cDNA sequences (see all 105): CA307428 BQ447804 CA309382 AI360639 CA422125 BG741988 CD367748 CF529886 CR610104 BU681570 CD108176 BG939578 AW149160 BU615191 BU738132 AA234624 BQ427804 AA400325 CA438517 M30496 BE501475 AW139870 BU630729 AI439126
GeneLoc Exon Structure
|
Expression
for UCHL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UCHL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGAAACTAG
About this image
See UCHL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UCHL3
SOURCE GeneReport for Unigene cluster: Hs.162241
UniProtKB/Swiss-Prot: UCHL3_HUMAN, P15374Tissue specificity: Highly expressed in heart, skeletal muscle, and testis
SABiosciences Expression via Pathway-Focused PCR Arrays including UCHL3: | Ubiquitination (Ubiquitylation) Pathway in human mouse rat | | Drug Metabolism: Phase I Enzymes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UCHL3
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCHL3 |
Orthologs
for UCHL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UCHL3 gene from 9/37 species (see all 37) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
UCHL31 |
ubiquitin carboxyl-terminal esterase L3 (ubiquitin more |
82.9(n)
86.09(a) |
|
395626 NM_204825.1 NP_990156.1 |
lizard
(Anolis carolinensis) |
Reptilia |
UCHL36 |
-- |
83(a) |
1 ↔ 1 |
3(87307306-87335897) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BX850313.12 |
-- |
79.9(n) |
|
BX850313.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.168892 |
Transcribed sequence with moderate similarity to protein more |
73.78(n) |
|
57072038 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Uch1 , 3 |
protein deubiquitination ubiquitin
C-terminal more3
Ubiquitin carboxy-terminal hydrolase1 |
50(a)3
55.11(n)1
51.35(a)1 |
|
22D43
333971 NM_001201752.11 NP_001188681.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F46E10.83 |
ubiquitin carboxyl-terminal hydrolase |
40(a) |
|
V(6512593-6514112) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
YUH1(YJR099W)4
YUH11 |
Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein more4
Yuh1p1 |
47.35(n)1
36.45(a)1 |
|
10(615576-616286)4
8535621, 4 NP_012633.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
UCH31 |
ubiquitin C-terminal hydrolase 3 |
55.91(n)
52.27(a) |
|
827466 NM_117857.2 NP_193484.1 |
rice
(Oryza sativa) |
Liliopsida |
Os02g06545001 |
hypothetical protein |
51.87(n)
47.09(a) |
|
4330187 NM_001054147.1 NP_001047612.1 |
ENSEMBL Gene Tree for UCHL3 (if available)
TreeFam Gene Tree for UCHL3 (if available) |
Paralogs
for UCHL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UCHL3 gene
- UCHL12
1 SIMAP similar gene for UCHL3 using alignment to 4 protein entries: UCHL3_HUMAN (see all proteins):UCHL1
UCHL3 for paralogs About GeneDecksing
|
Genomic Variants
for UCHL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UCHL3 (76123619 - 76180085 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for UCHL3
4 CNVs: 35184 9224 86912 76419 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UCHL3 |
|
Disorders
/ Diseases
for UCHL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UCHL3 for disorders About GeneDecksing
OMIM gene information: 603090
OMIM disorders: --
10  diseases for UCHL3: About MalaCardsparkinson's disease cervical carcinoma cervicitis colon cancer
breast cancer ataxia retinitis carcinoma
malaria neuronitis
1 Novoseek disease relationship for UCHL3 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
8 |
16734731 (5) |
Human Genome Epidemiology (HuGE) Navigator: UCHL3 (1 document)
Export disorders for UCHL3 gene to outside databases
|
Publications
for UCHL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UCHL3 gene, integrated from 9 sources (see all 63):
(articles sorted by number of sources associating them with UCHL3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. (PubMed id 2530630)1, 2, 3 Wilkinson K.D....Pohl J. (1989)
- Cleavage of the C-terminus of NEDD8 by UCH-L3. (PubMed id 9790970)1, 2, 9 Wada H.... Kamitani T. (1998)
- Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8- A resolution. (PubMed id 9233788)1, 2, 9 Johnston S.C.... Hill C.P. (1997)
- Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C- terminal hydrolase L3. (PubMed id 14595809)1, 2, 9 Nam M.J.... Hanash S.M. (2003)
- Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH- L3). (PubMed id 21762696)1, 2 Dennissen F.J.... van Leeuwen F.W. (2011)
- Ubiquitin dimers control the hydrolase activity of UC H-L3. (PubMed id 19154770)1, 2 Setsuie R....Wada K. (2009)
- Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. (PubMed id 15531586)1, 2 Misaghi S....Gaudet R. (2005)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3. (PubMed id 10518943)1, 9 Wilkinson K.D....Wand A.J. (1999)
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External Searches for UCHL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing UCHL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing UCHL3 gene
(According to HUGE)
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Specialized Databases showing UCHL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for UCHL3 gene:
Search GeneIP for patents involving UCHL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for UCHL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for UCHL3 | | OriGene shRNA RFP for UCHL3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UCHL3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UCHL3 | | | OriGene Protein Over-expression Lysate for UCHL3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UCHL3 | | OriGene 3'-UTR Clone for UCHL3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UCHL3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UCHL3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for UCHL3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UCHL3 | | OriGene Custom Protein Services for UCHL3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UCHL3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UCHL3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UCHL3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UCHL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UCHL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UCHL3 |
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| | Antibodies & Assays for UCHL3 |
| | | | Search Tocris compounds for UCHL3 |
| |  |  |  |  | | | | | | Recombinant Protein for UCHL3 |
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 | | | UCHL3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCHL3 |
|  |  |  | | | | ThermoFisher Antibody for UCHL3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCHL3 |
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