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Aliases for UCHL3 Gene

Aliases for UCHL3 Gene

  • Ubiquitin C-Terminal Hydrolase L3 2 3 5
  • Ubiquitin Carboxyl-Terminal Esterase L3 (Ubiquitin Thiolesterase) 2 3
  • Ubiquitin Thioesterase L3 3 4
  • Ubiquitin Thiolesterase 2 3
  • UCH-L3 3 4
  • Testicular Tissue Protein Li 221 3
  • EC 3.4.19.12 4

External Ids for UCHL3 Gene

Previous GeneCards Identifiers for UCHL3 Gene

  • GC13P074091
  • GC13P070118
  • GC13P075060
  • GC13P073921
  • GC13P075021
  • GC13P076123
  • GC13P056821

Summaries for UCHL3 Gene

Entrez Gene Summary for UCHL3 Gene

  • The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

GeneCards Summary for UCHL3 Gene

UCHL3 (Ubiquitin C-Terminal Hydrolase L3) is a Protein Coding gene. Among its related pathways are Neuroscience and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include peptidase activity and ubiquitin binding. An important paralog of this gene is UCHL1.

UniProtKB/Swiss-Prot for UCHL3 Gene

  • Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards Lys-48-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.

Gene Wiki entry for UCHL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCHL3 Gene

Genomics for UCHL3 Gene

Regulatory Elements for UCHL3 Gene

Enhancers for UCHL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UCHL3 on UCSC Golden Path with GeneCards custom track

Promoters for UCHL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UCHL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for UCHL3 Gene

Chromosome:
13
Start:
75,548,867 bp from pter
End:
75,606,020 bp from pter
Size:
57,154 bases
Orientation:
Plus strand

Genomic View for UCHL3 Gene

Genes around UCHL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCHL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCHL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCHL3 Gene

Proteins for UCHL3 Gene

  • Protein details for UCHL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15374-UCHL3_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase isozyme L3
    Protein Accession:
    P15374
    Secondary Accessions:
    • B2R970
    • Q5TBK8
    • Q6IBE9

    Protein attributes for UCHL3 Gene

    Size:
    230 amino acids
    Molecular mass:
    26183 Da
    Quaternary structure:
    • Preferentially binds diubiquitin; the interaction does not hydrolyze diubiquitin but, in vitro, inhibits the hydrolyzing activity on other substrates.
    Miscellaneous:
    • Identified as a tumor-specific antigen in colon cancer.

    Three dimensional structures from OCA and Proteopedia for UCHL3 Gene

neXtProt entry for UCHL3 Gene

Proteomics data for UCHL3 Gene at MOPED

Post-translational modifications for UCHL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UCHL3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UCHL3 (UCHL3)

No data available for DME Specific Peptides for UCHL3 Gene

Domains & Families for UCHL3 Gene

Gene Families for UCHL3 Gene

Protein Domains for UCHL3 Gene

Suggested Antigen Peptide Sequences for UCHL3 Gene

Graphical View of Domain Structure for InterPro Entry

P15374

UniProtKB/Swiss-Prot:

UCHL3_HUMAN :
  • Belongs to the peptidase C12 family.
Family:
  • Belongs to the peptidase C12 family.
genes like me logo Genes that share domains with UCHL3: view

Function for UCHL3 Gene

Molecular function for UCHL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by monoubiquitin and diubiquitin.
UniProtKB/Swiss-Prot Function:
Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards Lys-48-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.

Enzyme Numbers (IUBMB) for UCHL3 Gene

genes like me logo Genes that share phenotypes with UCHL3: view

Animal Models for UCHL3 Gene

MGI Knock Outs for UCHL3:

Animal Model Products

  • Taconic Biosciences Mouse Models for UCHL3

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UCHL3 Gene

Localization for UCHL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCHL3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCHL3 Gene COMPARTMENTS Subcellular localization image for UCHL3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
mitochondrion 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UCHL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with UCHL3: view

Pathways & Interactions for UCHL3 Gene

genes like me logo Genes that share pathways with UCHL3: view

Pathways by source for UCHL3 Gene

1 Cell Signaling Technology pathway for UCHL3 Gene
1 BioSystems pathway for UCHL3 Gene

Gene Ontology (GO) - Biological Process for UCHL3 Gene

None

No data available for SIGNOR curated interactions for UCHL3 Gene

Drugs & Compounds for UCHL3 Gene

(4) Drugs for UCHL3 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
LDN 57444 Pharma UCH-L1 inhibitor,reversible competitve, Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor 0
TCID Pharma 0
WP1130 Pharma Deubiquitinase (DUB) inhibitor, Cell permeable 0

(3) ApexBio Compounds for UCHL3 Gene

Compound Action Cas Number
LDN 57444 UCH-L1 inhibitor,reversible competitve 668467-91-2
TCID 30675-13-9
WP1130 Deubiquitinase (DUB) inhibitor, Cell permeable 856243-80-6
genes like me logo Genes that share compounds with UCHL3: view

Drug Products

Transcripts for UCHL3 Gene

Unigene Clusters for UCHL3 Gene

Ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCHL3 Gene

No ASD Table

Relevant External Links for UCHL3 Gene

GeneLoc Exon Structure for
UCHL3
ECgene alternative splicing isoforms for
UCHL3

Expression for UCHL3 Gene

mRNA expression in normal human tissues for UCHL3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UCHL3 Gene



SOURCE GeneReport for Unigene cluster for UCHL3 Gene Hs.162241

mRNA Expression by UniProt/SwissProt for UCHL3 Gene

P15374-UCHL3_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, and testis.
genes like me logo Genes that share expression patterns with UCHL3: view

Protein tissue co-expression partners for UCHL3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for UCHL3 Gene

Orthologs for UCHL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UCHL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UCHL3 35
  • 94.93 (n)
  • 99.13 (a)
UCHL3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCHL3 35
  • 95.65 (n)
  • 100 (a)
UCHL3 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uchl3 35
  • 90.43 (n)
  • 98.26 (a)
Uchl3 16
Uchl3 36
  • 98 (a)
OneToMany
Uchl4 36
  • 94 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia UCHL3 35
  • 100 (n)
  • 100 (a)
UCHL3 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Uchl3 35
  • 88.7 (n)
  • 97.83 (a)
oppossum
(Monodelphis domestica)
Mammalia UCHL3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UCHL3 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves UCHL3 35
  • 82.9 (n)
  • 86.09 (a)
UCHL3 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UCHL3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uchl3 35
  • 74.93 (n)
  • 74.35 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16889 35
uchl3 35
  • 68.41 (n)
  • 74.35 (a)
uchl3 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3304 35
fruit fly
(Drosophila melanogaster)
Insecta Uch 37
  • 50 (a)
Uch 35
  • 55.11 (n)
  • 51.35 (a)
Uch 36
  • 49 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012113 35
  • 50.68 (n)
  • 49.77 (a)
worm
(Caenorhabditis elegans)
Secernentea F46E10.8 37
  • 40 (a)
ubh-1 36
  • 41 (a)
ManyToMany
ubh-2 36
  • 31 (a)
ManyToMany
ubh-3 36
  • 37 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL314C 35
  • 49.59 (n)
  • 38.81 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E09967g 35
  • 51.36 (n)
  • 41.28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YUH1 35
  • 49.33 (n)
  • 40.46 (a)
YUH1 36
  • 31 (a)
OneToMany
YUH1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons UCH3 35
  • 55.91 (n)
  • 52.27 (a)
soybean
(Glycine max)
eudicotyledons Gma.11207 35
barley
(Hordeum vulgare)
Liliopsida Hv.6337 35
rice
(Oryza sativa)
Liliopsida Os02g0654500 35
  • 52.82 (n)
  • 49.32 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06372 35
  • 45.93 (n)
  • 40 (a)
Species with no ortholog for UCHL3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UCHL3 Gene

ENSEMBL:
Gene Tree for UCHL3 (if available)
TreeFam:
Gene Tree for UCHL3 (if available)

Paralogs for UCHL3 Gene

Paralogs for UCHL3 Gene

(1) SIMAP similar genes for UCHL3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UCHL3: view

Variants for UCHL3 Gene

Sequence variations from dbSNP and Humsavar for UCHL3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs966058 -- 75,579,919(+) AGTTT(C/G)AGAAG intron-variant
rs966059 -- 75,580,214(+) CCAAC(C/T)GAACA intron-variant
rs972542 -- 75,587,064(+) taaaa(C/G)gtaga intron-variant
rs973122 -- 75,552,101(+) GTACA(C/T)TATAT intron-variant
rs974373 -- 75,589,660(+) TTTAC(A/G)TATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UCHL3 Gene

Variant ID Type Subtype PubMed ID
nsv521444 CNV Gain 19592680
nsv900562 CNV Loss 21882294
dgv1692n71 CNV Loss 21882294
nsv1090 CNV Insertion 18451855
dgv1693n71 CNV Loss 21882294
dgv1694n71 CNV Loss 21882294
dgv1695n71 CNV Loss 21882294
dgv1696n71 CNV Loss 21882294
esv2747671 CNV Deletion 23290073
esv2747672 CNV Deletion 23290073
esv2747673 CNV Deletion 23290073
nsv900578 CNV Loss 21882294
esv2751152 CNV Loss 17911159
esv259826 OTHER Complex 20981092

Variation tolerance for UCHL3 Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UCHL3 Gene

HapMap Linkage Disequilibrium report
UCHL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCHL3 Gene

Disorders for UCHL3 Gene

Relevant External Links for UCHL3

Genetic Association Database (GAD)
UCHL3
Human Genome Epidemiology (HuGE) Navigator
UCHL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UCHL3

No disorders were found for UCHL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UCHL3 Gene

Publications for UCHL3 Gene

  1. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. (PMID: 2530630) Wilkinson K.D. … Pohl J. (Science 1989) 2 3 4 67
  2. Untangling the folding mechanism of the 5(2)-knotted protein UCH-L3. (PMID: 19476499) Andersson F.I. … Jackson S.E. (FEBS J. 2009) 3 23
  3. Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines. (PMID: 16402389) RolAcn U. … Masucci M.G. (Mol. Carcinog. 2006) 3 23
  4. Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C- terminal hydrolase L3. (PMID: 14595809) Nam M.J. … Hanash S.M. (Proteomics 2003) 3 23
  5. The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3. (PMID: 10518943) Wilkinson K.D. … Wand A.J. (J. Mol. Biol. 1999) 3 23

Products for UCHL3 Gene

Sources for UCHL3 Gene

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