Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UCHL1 Gene

Aliases for UCHL1 Gene

  • Ubiquitin C-Terminal Hydrolase L1 2 3 5
  • Ubiquitin Carboxyl-Terminal Esterase L1 (Ubiquitin Thiolesterase) 2 3
  • Neuron Cytoplasmic Protein 9.5 3 4
  • Ubiquitin Thioesterase L1 3 4
  • Ubiquitin Thiolesterase 2 3
  • PGP 9.5 3 4
  • Uch-L1 3 4
  • PGP9.5 3 4
  • Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 3
  • Epididymis Secretory Protein Li 53 3
  • Epididymis Luminal Protein 117 3
  • Ubiquitin C-Terminal Hydrolase 3
  • EC 3.4.19.12 4
  • EC 6.-.-.- 4
  • HEL-S-53 3
  • HEL-117 3
  • NDGOA 3
  • PGP95 3
  • PARK5 3

External Ids for UCHL1 Gene

Previous HGNC Symbols for UCHL1 Gene

  • PARK5

Previous GeneCards Identifiers for UCHL1 Gene

  • GC04P041330
  • GC04P041542
  • GC04P041108
  • GC04P041099
  • GC04P040953
  • GC04P040580

Summaries for UCHL1 Gene

Entrez Gene Summary for UCHL1 Gene

  • The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]

GeneCards Summary for UCHL1 Gene

UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a Protein Coding gene. Diseases associated with UCHL1 include Neurodegeneration With Optic Atrophy, Childhood Onset and Parkinson Disease 5. Among its related pathways are Alpha-synuclein signaling and Metabolism of proteins. GO annotations related to this gene include ligase activity and cysteine-type endopeptidase activity. An important paralog of this gene is UCHL3.

UniProtKB/Swiss-Prot for UCHL1 Gene

  • Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.

Tocris Summary for UCHL1 Gene

Gene Wiki entry for UCHL1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCHL1 Gene

Genomics for UCHL1 Gene

Regulatory Elements for UCHL1 Gene

Enhancers for UCHL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F041281 0.8 ENCODE 21.4 +24.8 24806 0.2 CTCF BRCA1 ZNF2 RAD21 GATA3 SMC3 ZNF652 MIXL1 ZNF654 TRIM22 UCHL1 LIMCH1 LOC105374421 UCHL1-AS1 GC04P041269 PIR50176 ENSG00000207481 GC04M041303
GH04F041256 0.2 ENCODE 11.8 +1.2 1242 2.8 SIN3A ZNF2 YY1 ZNF121 GLIS2 CBX5 KLF7 SP3 REST ZNF518A UCHL1 UCHL1-AS1 GC04P041269 PIR50176
GH04F041211 0.4 ENCODE 11.5 -41.7 -41670 6.3 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207 UCHL1 UCHL1-AS1 APBB2 RNU6-1195P
GH04F040976 0.8 Ensembl ENCODE 10.1 -279.8 -279813 0.4 CTCF TRIM22 THRB RAD21 KAT8 ZNF121 KLF16 ZNF143 SMC3 FOS APBB2 RNU6-836P UCHL1-AS1 UCHL1 RNA5SP160 GC04M040906
GH04F041185 0.5 Ensembl 9.9 -70.5 -70513 0.6 RNU6-836P UCHL1 UCHL1-AS1 APBB2 RNU6-1195P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UCHL1 on UCSC Golden Path with GeneCards custom track

Promoters for UCHL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001240043 987 2401 SIN3A ZNF2 YY1 ZNF121 GLIS2 CBX5 KLF7 SP3 REST ZNF518A

Genomic Location for UCHL1 Gene

Chromosome:
4
Start:
41,256,413 bp from pter
End:
41,268,455 bp from pter
Size:
12,043 bases
Orientation:
Plus strand

Genomic View for UCHL1 Gene

Genes around UCHL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UCHL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UCHL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCHL1 Gene

Proteins for UCHL1 Gene

  • Protein details for UCHL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09936-UCHL1_HUMAN
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase isozyme L1
    Protein Accession:
    P09936
    Secondary Accessions:
    • Q4W5K6
    • Q71UM0

    Protein attributes for UCHL1 Gene

    Size:
    223 amino acids
    Molecular mass:
    24824 Da
    Quaternary structure:
    • Monomer. Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5.
    Miscellaneous:
    • Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. In AD, UCHL1 was found to be associated with neurofibrillary tangles. In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8.
    SequenceCaution:
    • Sequence=CAA28443.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UCHL1 Gene

neXtProt entry for UCHL1 Gene

Post-translational modifications for UCHL1 Gene

Other Protein References for UCHL1 Gene

No data available for DME Specific Peptides for UCHL1 Gene

Domains & Families for UCHL1 Gene

Protein Domains for UCHL1 Gene

Graphical View of Domain Structure for InterPro Entry

P09936

UniProtKB/Swiss-Prot:

UCHL1_HUMAN :
  • Belongs to the peptidase C12 family.
Family:
  • Belongs to the peptidase C12 family.
genes like me logo Genes that share domains with UCHL1: view

Function for UCHL1 Gene

Molecular function for UCHL1 Gene

GENATLAS Biochemistry:
ubiquitin carboxy-terminal esterase L1,26.2kDa,abundantly expressed in the brain (neurons and neuroendocrin cells),also found in Lewy bodies,involved in the ubiquitin dependent proteolytic pathway,with a bifunctional regulatory DNA element contributing to neuron restricted transcription,overexpressed in non-small cell lung cancer
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=122 nM for Ub-AMC {ECO:0000269 PubMed:12705903, ECO:0000269 PubMed:8639624, ECO:0000269 PubMed:9774100}; KM=1.20 uM for ubiquitin ethyl ester {ECO:0000269 PubMed:12705903, ECO:0000269 PubMed:8639624, ECO:0000269 PubMed:9774100}; Vmax=0.47 umol/min/mg enzyme toward Ub-AMC {ECO:0000269 PubMed:12705903, ECO:0000269 PubMed:8639624, ECO:0000269 PubMed:9774100}; Vmax=25 umol/min/mg enzyme toward ubiquitin ethyl ester {ECO:0000269 PubMed:12705903, ECO:0000269 PubMed:8639624, ECO:0000269 PubMed:9774100};
UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.

Enzyme Numbers (IUBMB) for UCHL1 Gene

Gene Ontology (GO) - Molecular Function for UCHL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IDA 8639624
GO:0004843 thiol-dependent ubiquitin-specific protease activity IEA,IBA --
GO:0005515 protein binding IPI 12082530
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with UCHL1: view
genes like me logo Genes that share phenotypes with UCHL1: view

Human Phenotype Ontology for UCHL1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for UCHL1 Gene

MGI Knock Outs for UCHL1:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UCHL1

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for UCHL1 Gene

Localization for UCHL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UCHL1 Gene

Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. Note=About 30% of total UCHL1 is associated with membranes in brain.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCHL1 Gene COMPARTMENTS Subcellular localization image for UCHL1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 3
endoplasmic reticulum 3
mitochondrion 2
plasma membrane 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UCHL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,TAS 16130169
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with UCHL1: view

Pathways & Interactions for UCHL1 Gene

genes like me logo Genes that share pathways with UCHL1: view

Pathways by source for UCHL1 Gene

1 Cell Signaling Technology pathway for UCHL1 Gene
1 KEGG pathway for UCHL1 Gene
1 GeneGo (Thomson Reuters) pathway for UCHL1 Gene
1 Qiagen pathway for UCHL1 Gene

Gene Ontology (GO) - Biological Process for UCHL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia IEA --
GO:0006508 proteolysis IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007409 axonogenesis IEA --
GO:0007412 axon target recognition IEA --
genes like me logo Genes that share ontologies with UCHL1: view

No data available for SIGNOR curated interactions for UCHL1 Gene

Drugs & Compounds for UCHL1 Gene

(12) Drugs for UCHL1 Gene - From: ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Flurofamide Pharma Urease inhibitor 0
LDN 57444 Pharma UCH-L1 inhibitor,reversible competitve, Ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor 0
TCID Pharma 0
WP1130 Pharma Deubiquitinase (DUB) inhibitor, Cell permeable 0
(Z)-Pugnac Pharma Inhibitor of O-GlcNAcase and β-hexosaminidase, O-GlcNAcase and beta-hexosaminidase inhibitor 0

(5) Additional Compounds for UCHL1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
JZP 430
1672691-74-5

(5) Tocris Compounds for UCHL1 Gene

Compound Action Cas Number
(Z)-Pugnac O-GlcNAcase and beta-hexosaminidase inhibitor 132489-69-1
Flurofamide Urease inhibitor 70788-28-2
JZP 430 Potent and irreversible alpha/beta-hydrolase domain 6 (ABHD6) inhibitor 1672691-74-5
Thiamet G Potent O-GlcNAcase inhibitor 1009816-48-1
WWL 70 Potent ABHD6 inhibitor 947669-91-2

(4) ApexBio Compounds for UCHL1 Gene

Compound Action Cas Number
Flurofamide 70788-28-2
LDN 57444 UCH-L1 inhibitor,reversible competitve 668467-91-2
TCID 30675-13-9
WP1130 Deubiquitinase (DUB) inhibitor, Cell permeable 856243-80-6
genes like me logo Genes that share compounds with UCHL1: view

Transcripts for UCHL1 Gene

Unigene Clusters for UCHL1 Gene

Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UCHL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UCHL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: - - - -
SP3:
SP4: - -
SP5:

Relevant External Links for UCHL1 Gene

GeneLoc Exon Structure for
UCHL1
ECgene alternative splicing isoforms for
UCHL1

Expression for UCHL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UCHL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UCHL1 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.8), Brain - Cortex (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.4), and Brain - Frontal Cortex (BA9) (x5.3).

Protein differential expression in normal tissues from HIPED for UCHL1 Gene

This gene is overexpressed in Amniocyte (23.5), Brain (13.1), and Liver (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UCHL1 Gene



Protein tissue co-expression partners for UCHL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UCHL1 Gene:

UCHL1

SOURCE GeneReport for Unigene cluster for UCHL1 Gene:

Hs.518731

mRNA Expression by UniProt/SwissProt for UCHL1 Gene:

P09936-UCHL1_HUMAN
Tissue specificity: Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.
genes like me logo Genes that share expression patterns with UCHL1: view

Primer Products

Orthologs for UCHL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UCHL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UCHL1 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia UCHL1 34 35
  • 93.27 (n)
cow
(Bos Taurus)
Mammalia UCHL1 34 35
  • 91.93 (n)
rat
(Rattus norvegicus)
Mammalia Uchl1 34
  • 88.34 (n)
mouse
(Mus musculus)
Mammalia Uchl1 34 16 35
  • 88.04 (n)
oppossum
(Monodelphis domestica)
Mammalia UCHL1 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 36 (a)
ManyToMany
chicken
(Gallus gallus)
Aves UCHL1 34
  • 75.49 (n)
UCH-L1 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UCHL1 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia uchl1 34
  • 65.24 (n)
Str.6096 34
zebrafish
(Danio rerio)
Actinopterygii uchl1 34 35
  • 65.59 (n)
wufc55h08 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8436 34
fruit fly
(Drosophila melanogaster)
Insecta Uch 36 35
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea F46E10.8 36
  • 37 (a)
ubh-1 35
  • 36 (a)
ManyToMany
ubh-3 35
  • 33 (a)
ManyToMany
ubh-2 35
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YUH1 35
  • 25 (a)
OneToMany
Species where no ortholog for UCHL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UCHL1 Gene

ENSEMBL:
Gene Tree for UCHL1 (if available)
TreeFam:
Gene Tree for UCHL1 (if available)

Paralogs for UCHL1 Gene

Paralogs for UCHL1 Gene

(1) SIMAP similar genes for UCHL1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for UCHL1 Gene

genes like me logo Genes that share paralogs with UCHL1: view

Variants for UCHL1 Gene

Sequence variations from dbSNP and Humsavar for UCHL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs121917767 Parkinson disease 5 (PARK5) [MIM:613643], other 41,260,751(+) ACAAT(C/G/T)GGACT reference, synonymous-codon, missense
rs397515634 Neurodegeneration with optic atrophy, childhood-onset (NDGOA) [MIM:615491], Pathogenic 41,256,996(+) GATGG(A/C)GATCA upstream-variant-2KB, reference, missense
rs150601238 Uncertain significance 41,261,759(+) AGAAA(A/C)TGTCC reference, missense
rs5030732 Uncertain significance 41,257,616(+) GCTGT(A/C)CCGGC upstream-variant-2KB, reference, missense
rs10004654 -- 41,263,076(+) tgggc(C/T)tagaa intron-variant

Variation tolerance for UCHL1 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.35; 88.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UCHL1 Gene

Human Gene Mutation Database (HGMD)
UCHL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UCHL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UCHL1 Gene

Disorders for UCHL1 Gene

MalaCards: The human disease database

(41) MalaCards diseases for UCHL1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neurodegeneration with optic atrophy, childhood onset
  • neurodegeneration with optic atrophy, childhood-onset
parkinson disease 5
  • parkinson disease 5, susceptibility to
parkinson disease susceptibility
uchl1-related parkinson disease susceptibility
  • parkinson disease 5, susceptibility to
hodgkin's paragranuloma
  • hodgkin disease
- elite association - COSMIC cancer census association via MalaCards
Search UCHL1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

UCHL1_HUMAN
  • Neurodegeneration with optic atrophy, childhood-onset (NDGOA) [MIM:615491]: A progressive neurodegenerative syndrome characterized by childhood onset blindness, cerebellar ataxia, nystagmus, dorsal column dysfuction, and spasticity with upper motor neuron dysfunction. {ECO:0000269 PubMed:23359680}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Parkinson disease 5 (PARK5) [MIM:613643]: A complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia. {ECO:0000269 PubMed:9774100}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for UCHL1

Genetic Association Database (GAD)
UCHL1
Human Genome Epidemiology (HuGE) Navigator
UCHL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UCHL1
genes like me logo Genes that share disorders with UCHL1: view

No data available for Genatlas for UCHL1 Gene

Publications for UCHL1 Gene

  1. UCHL-1 is not a Parkinson's disease susceptibility gene. (PMID: 16450370) Healy D.G. … Wood N.W. (Ann. Neurol. 2006) 3 4 22 46 64
  2. UCHL1 is a Parkinson's disease susceptibility gene. (PMID: 15048890) Maraganore D.M. … Rocca W.A. (Ann. Neurol. 2004) 3 4 22 46 64
  3. The ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism does not confer protection against idiopathic Parkinson's disease. (PMID: 11027850) Mellick G.D. … Silburn P.A. (Neurosci. Lett. 2000) 3 4 22 46 64
  4. Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. (PMID: 20439756) Boudreaux D.A. … Das C. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 22 64
  5. Polymorphism of HD and UCHL-1 genes in Huntington's disease. (PMID: 19683447) Xu E.H. … Jia J.P. (J Clin Neurosci 2009) 3 22 46 64

Products for UCHL1 Gene

Sources for UCHL1 Gene

Content
Loading form....