Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UCHL1 Gene

protein-coding   GIFtS: 72
GCID: GC04P041174

Ubiquitin Carboxyl-Terminal Esterase L1 (Ubiquitin Thiolesterase)


(Previous symbol: PARK5)
  See UCHL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ubiquitin Carboxyl-Terminal Esterase L1 (Ubiquitin Thiolesterase)1 2     PGP952
PARK51 2 5     Uch-L12
Neuron Cytoplasmic Protein 9.52 3     Epididymis Luminal Protein 1172
Ubiquitin Thioesterase L12 3     Ubiquitin C-Terminal Hydrolase2
PGP9.52 3     Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L12
PGP 9.52 3     EC 3.4.19.123
NDGOA2 5     EC 6.-.-.-3
HEL-1172     UCH-L13

External Ids:    HGNC: 125131   Entrez Gene: 73452   Ensembl: ENSG000001542777   OMIM: 1913425   UniProtKB: P099363   

Export aliases for UCHL1 gene to outside databases

Previous GC identifers: GC04P041330 GC04P041542 GC04P041108 GC04P041099 GC04P040953 GC04P040580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UCHL1 Gene:
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that
hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the
neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with
Parkinson disease.(provided by RefSeq, Sep 2009)

GeneCards Summary for UCHL1 Gene:
UCHL1 (ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)) is a protein-coding gene. Diseases associated with UCHL1 include parkinson disease 5, and neurodegeneration with optic atrophy, childhood onset. GO annotations related to this gene include cysteine-type endopeptidase activity and ubiquitin thiolesterase activity. An important paralog of this gene is UCHL3.

UniProtKB/Swiss-Prot: UCHL1_HUMAN, P09936
Function: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated
proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine
of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may
have ATP-independent ubiquitin ligase activity

Gene Wiki entry for UCHL1 (Ubiquitin carboxy-terminal hydrolase L1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_006238.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the UCHL1 gene promoter:
         p53   AP-1   HTF   ATF-2   Cdc5   CREB   MZF-1   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUCHL1 promoter sequence
   Search Chromatin IP Primers for UCHL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UCHL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p13   HGNC cytogenetic band: 4p13

UCHL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCHL1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P041174:  view genomic region     (about GC identifiers)

Start:
41,258,430 bp from pter      End:
41,270,472 bp from pter
Size:
12,043 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UCHL1_HUMAN, P09936 (See protein sequence)
Recommended Name: Ubiquitin carboxyl-terminal hydrolase isozyme L1 precursor  
Size: 223 amino acids; 24824 Da
Subunit: Monomer. Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5
Miscellaneous: Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of
Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease
(PD) patients. In AD, UCHL1 was found to be associated with neurofibrillary tangles. In contrast to UCHL3, does
not hydrolyze a peptide bond at the C-terminal glycine of NEDD8
Caution: PubMed:9774100 reports the association of mutation Ile93Met with Parkinson disease. However, according to
PubMed:16450370 this association is uncertain and UCHL1 is not a susceptibility gene for Parkinson disease
Sequence caution: Sequence=CAA28443.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for UCHL1 (see all 7):
2ETL (3D)        2LEN (3D)        3IFW (3D)        3IRT (3D)        3KVF (3D)        3KW5 (3D)    
Secondary accessions: Q4W5K6 Q71UM0

Explore the universe of human proteins at neXtProt for UCHL1: NX_P09936

Explore proteomics data for UCHL1 at MOPED

Post-translational modifications: 

  • O-glycosylated (By similarity)1
  • Ubiquitination2 at Lys15, Lys78, Lys83, Lys115
  • Modification sites at PhosphoSitePlus

  • See UCHL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004172.2  
    ENSEMBL proteins: 
     ENSP00000426634   ENSP00000422542   ENSP00000284440   ENSP00000425714   ENSP00000423348  
     ENSP00000426895   ENSP00000423623  

    UCHL1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant UCHL1 Protein
    R&D Systems Recombinant & Natural Proteins for UCHL1 (UCH-L1)
    Enzo Life Sciences proteins for UCHL1
    OriGene Purified Proteins for UCHL1
    OriGene Protein Over-expression Lysate for UCHL1
    OriGene MassSpec for UCHL1
    OriGene Custom Protein Services for UCHL1
    GenScript Custom Purified and Recombinant Proteins Services for UCHL1
    Novus Biologicals UCHL1 Proteins
    Novus Biologicals UCHL1 Lysates
    Sino Biological Recombinant Protein for UCHL1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for UCHL1
    Cloud-Clone Corp. Proteins for UCHL1

     
    Search eBioscience for Proteins for UCHL1 

    UCHL1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of UCHL1
    R&D Systems Antibodies for UCHL1 (UCH-L1)
    Cell Signaling Technology (CST) Antibodies for UCHL1 
    OriGene Antibodies for UCHL1
    OriGene Custom Antibody Services for UCHL1
    Novus Biologicals UCHL1 Antibodies
    Abcam antibodies for UCHL1 (P15374, P09936)
    Cloud-Clone Corp. Antibodies for UCHL1
    ThermoFisher Antibody for UCHL1
    LSBio Antibodies in human, mouse, rat for UCHL1

    UCHL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UCHL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UCHL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UCHL1
    Cloud-Clone Corp. CLIAs for UCHL1
    Search eBioscience for ELISAs for UCHL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PARK: Parkinson disease

    1 InterPro protein domain:
     IPR001578 Peptidase_C12_UCH

    Graphical View of Domain Structure for InterPro Entry P09936

    ProtoNet protein and cluster: P09936

    1 Blocks protein domain: IPB001578 Ubiquitin carboxyl-terminal hydrolase

    UniProtKB/Swiss-Prot: UCHL1_HUMAN, P09936
    Similarity: Belongs to the peptidase C12 family


    Find genes that share domains with UCHL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UCHL1_HUMAN, P09936
    Function: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated
    proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine
    of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may
    have ATP-independent ubiquitin ligase activity
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
    Biophysicochemical properties: Kinetic parameters: KM=122 nM for Ub-AMC; KM=1.20 uM for ubiquitin ethyl ester;
    Vmax=0.47 umol/min/mg enzyme toward Ub-AMC; Vmax=25 umol/min/mg enzyme toward ubiquitin ethyl ester;

         Genatlas biochemistry entry for UCHL1:
    ubiquitin carboxy-terminal esterase L1,26.2kDa,abundantly expressed in the brain (neurons and neuroendocrin
    cells),also found in Lewy bodies,involved in the ubiquitin dependent proteolytic pathway,with a bifunctional
    regulatory DNA element contributing to neuron restricted transcription,overexpressed in non-small cell lung
    cancer

         Enzyme Numbers (IUBMB): EC 6.-.-.-1 EC 3.4.19.121

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IDA8639624
    GO:0004221ubiquitin thiolesterase activity TAS9521656
    GO:0004843ubiquitin-specific protease activity IEA--
    GO:0005515protein binding IPI12082530
    GO:0008242omega peptidase activity IDA9521656
         
    Find genes that share ontologies with UCHL1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UCHL1:
     Increased cell number in G2M,  

         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Uchl1):
     behavior/neurological  cardiovascular system  digestive/alimentary  growth/size/body  hematopoietic system 
     integument  limbs/digits/tail  liver/biliary system  mortality/aging  nervous system 
     renal/urinary system  respiratory system  skeleton 

    Find genes that share phenotypes with UCHL1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UCHL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UCHL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UCHL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UCHL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target UCHL1:
    hsa-mir-877-5p (MIRT037262), hsa-mir-181a-5p (MIRT047324), hsa-mir-193b-3p (MIRT041399), hsa-mir-92a-3p (MIRT048928)

    Block miRNA regulation of human, mouse, rat UCHL1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate UCHL1:
    hsa-miR-4291 hsa-miR-922 hsa-miR-561 hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidUCHL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UCHL1
    Predesigned siRNA for gene silencing in human, mouse, rat UCHL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UCHL1

    Clone
    Products:
         
    OriGene clones in human, mouse for UCHL1 (see all 6)
    OriGene ORF clones in mouse, rat for UCHL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UCHL1 (NM_004181)
    Sino Biological Human cDNA Clone for UCHL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCHL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCHL1
    Addgene plasmids for UCHL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UCHL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for UCHL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCHL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UCHL1_HUMAN, P09936: Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. Note=About 30% of total UCHL1 is
    associated with membranes in brain
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol4
    nucleus4
    cytoskeleton1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS16130169
    GO:0005789endoplasmic reticulum membrane IEA--

    Find genes that share ontologies with UCHL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for UCHL1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Proteasome Degradation0.57
    Parkinson's Disease Pathway0.31
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.57
    3Cell cycle Regulation of G1 S transition part 2
    Immune response MIF JAB1 signaling0.32
    4Protein Stability
    Protein Stability
    5Parkinsons Disease Pathway
    Parkinsons Disease Pathway


    Find genes that share SuperPaths with UCHL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for UCHL1
        Parkinson's Disease Pathway

    2 Cell Signaling Technology (CST) Pathways for UCHL1
        Neuroscience
    Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for UCHL1
        Immune response MIF-JAB1 signaling

    3 BioSystems Pathways for UCHL1
        Parkinsons Disease Pathway
    Proteasome Degradation
    Alpha-synuclein signaling



    1 Kegg Pathway  (Kegg details for UCHL1):
        Parkinson's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UCHL1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat
              Nephrotoxicity in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UCHL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UCHL1 (P099361, 2, 3 ENSP000002844404) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929051, 3, ENSP000003505124EBI-714860,EBI-594661 I2D: score=4 STRING: ENSP00000350512
    CBX1P839162, 3MINT-64014 I2D: score=5 
    SMN1Q166373, ENSP000003700834I2D: score=1 STRING: ENSP00000370083
    NEDD8Q158432, 3, ENSP000002504954MINT-64271 I2D: score=5 STRING: ENSP00000250495
    EGFRP005331, 3, ENSP000002754934EBI-714860,EBI-297353 I2D: score=2 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002931response to ischemia IEA--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006950response to stress ----
    GO:0007409axonogenesis ----
    GO:0007412axon target recognition IEA--

    Find genes that share ontologies with UCHL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for UCHL1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (Z)-PugnacO-GlcNAcase and beta-hexosaminidase inhibitor[132489-69-1]
    Thiamet GPotent O-GlcNAcase inhibitor[1009816-48-1]
    JW 480Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)[1354359-53-7]
    FlurofamideUrease inhibitor[70788-28-2]
    WWL 70Potent ABHD6 inhibitor[947669-91-2]

    9 Novoseek inferred chemical compound relationships for UCHL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sodium borohydride 37.1 1 9252784 (1)
    dopamine 20.7 1 14579120 (1)
    12-o-tetradecanoylphorbol 13-acetate 8.3 1 7756180 (1)
    glyceraldehyde 3-phosphate 8.19 1 17522440 (1)
    lysine 0 2 17259170 (1), 15718234 (1)
    tyrosine 0 3 16626667 (1), 10923647 (1)
    superoxide 0 3 18079679 (1), 16391823 (1)
    serine 0 2 16626667 (1)
    cysteine 0 3 14722078 (1), 17449248 (1), 20439756 (1)



    Find genes that share compounds with UCHL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UCHL1 gene: 
    NM_004181.4  

    Unigene Cluster for UCHL1:

    Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
    Hs.518731  [show with all ESTs]
    Unigene Representative Sequence: AB209038
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514924 ENST00000503431 ENST00000284440(uc003gvo.3) ENST00000381760(uc003gvp.3)
    ENST00000512419 ENST00000505232 ENST00000504818 ENST00000508768 ENST00000512788
    ENST00000472501 ENST00000514764 ENST00000510566
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UCHL1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate UCHL1:
    hsa-miR-4291 hsa-miR-922 hsa-miR-561 hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidUCHL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UCHL1
    Predesigned siRNA for gene silencing in human, mouse, rat UCHL1
    Clone
    Products:
         
    OriGene clones in human, mouse for UCHL1 (see all 6)
    OriGene ORF clones in mouse, rat for UCHL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UCHL1 (NM_004181)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UCHL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCHL1
    Addgene plasmids for UCHL1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UCHL1
    OriGene qSTAR qPCR primer pairs in human, mouse for UCHL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UCHL1
      QuantiTect SYBR Green Assays in human, mouse, rat UCHL1
      QuantiFast Probe-based Assays in human, mouse, rat UCHL1

    Additional mRNA sequence: 

    AB209038.1 AK054579.1 AK055249.1 AK315368.1 BC000332.2 BC005117.1 BC006305.2 BC018838.2 
    X04741.1 

    Selected DOTS entries (see all 29):

    DT.91767332  DT.92409770  DT.95213398  DT.100877608  DT.95213387  DT.95314607  DT.97787074  DT.95278796 
    DT.100833633  DT.121262545  DT.100877596  DT.99948987  DT.100877595  DT.100877605  DT.100877609  DT.121262544 
    DT.75107755  DT.91680207  DT.95213388  DT.95213397  DT.100642141  DT.121262493  DT.121262563  DT.75186422 

    Selected AceView cDNA sequences (see all 1015):

    R39313 BQ943913 AW247633 AI654181 BQ267597 BQ924568 BM693402 BQ718683 
    BQ437724 BQ926463 BI710780 CR623929 CF127837 AK054579 BQ723369 BE796108 
    BM667940 AI879962 BU782879 CR614674 BU952447 BQ581977 AW087082 BQ430337 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for UCHL1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                    -                                                           -               
    SP2:                    -     -     -                                               -               
    SP3:                                                                                                
    SP4:                    -     -                                                                     
    SP5:                                                                                                


    ECgene alternative splicing isoforms for UCHL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UCHL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTCTAAAA
    UCHL1 Expression
    About this image


    UCHL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Pancreas (Endocrine System)    fully expand to see all 3 entries
             Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
             Islets of Langerhans
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
    UCHL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UCHL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518731

    UniProtKB/Swiss-Prot: UCHL1_HUMAN, P09936
    Tissue specificity: Found in neuronal cell bodies and processes throughout the neocortex (at protein level).
    Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary.
    Down-regulated in brains from Parkinson disease and Alzheimer disease patients

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UCHL1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat
              Nephrotoxicity in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UCHL1
    OriGene qSTAR qPCR primer pairs in human, mouse for UCHL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UCHL1
    QuantiTect SYBR Green Assays in human, mouse, rat UCHL1
    QuantiFast Probe-based Assays in human, mouse, rat UCHL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCHL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UCHL1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Uchl11 , 5 ubiquitin carboxy-terminal hydrolase L11, 5 88.04(n)1
    95.52(a)1
      5 (35.95 cM)5
    222231  NM_011670.21  NP_035800.21 
     666760985 
    chicken
    (Gallus gallus)
    Aves UCHL11 ubiquitin carboxyl-terminal esterase L1 (ubiquitin more 75.49(n)
    75.34(a)
      770302  NM_001080212.1  NP_001073681.1 
    lizard
    (Anolis carolinensis)
    Reptilia UCHL16
    ubiquitin carboxyl-terminal esterase L1 (ubiquitin...
    78(a)
    1 ↔ 1
    5(100567218-100576797)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.60962 Transcribed sequence with weak similarity to protein more 75.17(n)    AL893221.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc55h082 Danio rerio mRNA similar to ubiquitin carboxyl-terminal more 72.98(n)    BC049044.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Uch3 protein deubiquitination ubiquitin
    C-terminal more
    45(a)   22D4   --
    worm
    (Caenorhabditis elegans)
    Secernentea F46E10.83 ubiquitin carboxyl-terminal hydrolase 37(a)   V(6512593-6514112)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YUH16
    Ubiquitin C-terminal hydrolase that cleaves ubiqui...
    25(a)
    1 → many
    X(615576-616286) YJR099W


    ENSEMBL Gene Tree for UCHL1 (if available)
    TreeFam Gene Tree for UCHL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UCHL1 gene
    UCHL32  
    1 SIMAP similar gene for UCHL1 using alignment to 7 protein entries:     UCHL1_HUMAN (see all proteins):
    UCHL3

    Find genes that share paralogs with UCHL1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for UCHL1
    PGOHUM00000242729 PGOHUM00000242730


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UCHL1 (see all 330)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0708754
    Neurodegeneration with optic atrophy, childhood-onset (NDGOA)4--see VAR_0708752 E A mis40--------
    VAR_0156784
    Parkinson disease 5 (PARK5)4--see VAR_0156782 I M mis40--------
    rs1219177671,2
    Cpathogenic141152790(+) ACAATC/G/TGGACT 2 I M mis10--------
    rs50307321,2,,4
    Cunknown141149655(+) GCTGTC/ACCGGC 2 /Y /S mis15Minor allele frequency- A:0.35NA EA 246
    rs1390538351,2
    C--41147098(+) TTAGCC/TGGGTG 1 -- us2k10--------
    rs119473291,2
    C,F,H--41147135(+) tactcA/C/Tggagg 1 -- us2k11WA 2
    rs1498847351,2
    --41147229(+) AGAGCA/GAGACT 1 -- us2k10--------
    rs1930888311,2
    --41147508(+) TTGAGA/GGAAAA 1 -- us2k10--------
    rs1850536621,2
    --41147532(+) AGATTC/TACCCA 1 -- us2k10--------
    rs1459598991,2
    --41147543(+) TTAAGC/TTCCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UCHL1 (41258430 - 41270472 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for UCHL1: --
    Human Gene Mutation Database (HGMD): UCHL1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UCHL1
    DNA2.0 Custom Variant and Variant Library Synthesis for UCHL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 191342   
    OMIM disorders: 613643  615491  
    UniProtKB/Swiss-Prot: UCHL1_HUMAN, P09936
  • Parkinson disease 5 (PARK5) [MIM:613643]: A complex neurodegenerative disorder with manifestations
    ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian
    symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body
    pathology, autonomic dysfunction, hallucinations and paranoia. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 5 diseases for UCHL1:    
    About MalaCards
    parkinson disease 5    neurodegeneration with optic atrophy, childhood onset    parkinson disease 1    large cell carcinoma
    parkinson's disease


    Find genes that share disorders with UCHL1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for UCHL1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 79.9 70 12775255 (2), 12836396 (2), 15882803 (2), 16316632 (2) (see all 43)
    neurodegenerative diseases 65.7 6 17586089 (2), 15911766 (1), 17925890 (1), 16537382 (1)
    parkinsonism 52.8 4 11455179 (2), 12836396 (1), 15228595 (1)
    neurodegeneration 49.7 4 10923647 (1), 15911766 (1), 20231490 (1)
    neurofibrillary tangles 33.3 3 14722078 (1), 20231490 (1)
    alzheimers disease 31 7 17925890 (2), 14722078 (1), 20144674 (1), 16698101 (1) (see all 5)
    huntington disease 25.8 5 19683447 (2), 15911766 (1), 16369839 (1)
    tumors 14.6 37 16734731 (4), 14522054 (3), 18820707 (2), 16402389 (2) (see all 14)
    nsclc 10 5 10487828 (3), 18820707 (1)
    cancer lung 6.39 8 10487828 (4), 17108109 (1), 14522054 (1)

    GeneTests: UCHL1
    GeneReviews: UCHL1
    Genetic Association Database (GAD): UCHL1
    Human Genome Epidemiology (HuGE) Navigator: UCHL1 (34 documents)

    Export disorders for UCHL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UCHL1 gene, integrated from 10 sources (see all 303):
    (articles sorted by number of sources associating them with UCHL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. UCHL1 is a Parkinson's disease susceptibility gene. (PubMed id 15048890)1, 2, 4, 9 Maraganore D.M....Rocca W.A. (Ann. Neurol. 2004)
    2. UCHL-1 is not a Parkinson's disease susceptibility gene. (PubMed id 16450370)1, 2, 4, 9 Healy D.G.... Wood N.W. (Ann. Neurol. 2006)
    3. The ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism does not confer protection against idiopathic Parkinson's disease. (PubMed id 11027850)1, 2, 4, 9 Mellick G.D. and Silburn P.A. (Neurosci. Lett. 2000)
    4. The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells. (PubMed id 18411255)1, 2, 9 Kyratzi E.... Stefanis L. (Hum. Mol. Genet. 2008)
    5. Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1. (PubMed id 16537382)1, 2, 9 Das C.... Petsko G.A. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    6. Oxidative modifications and down-regulation of ubiquitin carboxyl- terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. (PubMed id 14722078)1, 2, 9 Choi J.... Li L. (J. Biol. Chem. 2004)
    7. Alterations of structure and hydrolase activity of parkinsonism- associated human ubiquitin carboxyl-terminal hydrolase L1 variants. (PubMed id 12705903)1, 2, 9 Nishikawa K.... Wada K. (Biochem. Biophys. Res. Commun. 2003)
    8. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. (PubMed id 12408865)1, 2, 9 Liu Y.... Lansbury P.T. Jr. (Cell 2002)
    9. The gene for human neurone specific ubiquitin C-terminal hydrolase (UCHL1, PGP9.5) maps to chromosome 4p14. (PubMed id 1840236)1, 3, 9 Edwards Y.H....Day I.N. (Ann. Hum. Genet. 1991)
    10. Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease. (PubMed id 19261853)1, 2, 9 Liu Z.... Lansbury P.T. Jr. (Proc. Natl. Acad. Sci. U.S.A. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7345 HGNC: 12513 AceView: UCHL1 Ensembl:ENSG00000154277 euGenes: HUgn7345
    ECgene: UCHL1 Kegg: 7345 H-InvDB: UCHL1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UCHL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UCHL1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/gtr/tests/299416/
    Wikipedia http://en.wikipedia.org/wiki/Ubiquitin_carboxy-terminal_hydrolase_L1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UCHL1 gene:
    Search GeneIP for patents involving UCHL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant UCHL1 Protein
     EMD Millipore Mono- and Polyclonal Antibodies for the study of UCHL1
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for UCHL1 (UCH-L1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for UCHL1 (UCH-L1)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UCHL1   OriGene RNAi products in human, mouse, rat for UCHL1  
     OriGene qPCR primer pairs and template standards for UCHL1   OriGene Protein Over-expression Lysate for UCHL1  
     OriGene MassSpec something-or-other for UCHL1   OriGene clones in human, mouse for UCHL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for UCHL1   OriGene Purified Protein for UCHL1  
     OriGene ORF clones in mouse, rat for UCHL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UCHL1   OriGene Custom Protein Services for UCHL1  

     
     
     Block miRNA regulation of human, mouse, rat UCHL1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UCHL1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UCHL1 Predesigned siRNA for gene silencing in human, mouse, rat UCHL1
     QuantiFast Probe-based Assays in human, mouse, rat UCHL1 QuantiTect SYBR Green Assays in human, mouse, rat UCHL1
     PCR Arrays including human, mouse, rat UCHL1 Search Chromatin IP Primers for UCHL1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UCHL1  GeneGlobe Interaction Network for UCHL1
     Regulatory tfbs in UCHL1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UCHL1 GenScript cDNA clones with any tag delivered in your preferred vector for UCHL1
     GenScript Custom Assay Services for UCHL1 GenScript Custom overexpressing Cell Line Services for UCHL1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for UCHL1 

     Tocris compounds for UCHL1
     Proteins for UCHL1
     Browse Sino Biological Cell Lysates
     cDNA Clones for UCHL1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for UCHL1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UCHL1 antibodies
     UCHL1 proteins
     UCHL1 lysates
     Antibodies for UCHL1
     See all of Abcam's Antibodies, Kits and Proteins for UCHL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for UCHL1
     Proteins for UCHL1
     Antibodies for UCHL1
     ELISAs for UCHL1
     CLIAs for UCHL1



     Browse ESI BIO Cell Lines and PureStem Progenitors for UCHL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UCHL1
     SwitchGear 3'UTR luciferase reporter plasmids for UCHL1
     SwitchGear Promoter luciferase reporter plasmids for UCHL1
     ThermoFisher Antibody for UCHL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UCHL1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UCHL1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UCHL1
     LSBio Antibodies in human, mouse, rat for UCHL1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for UCHL1
      Search eBioscience for proteins for UCHL1
      Search eBioscience for elisas for UCHL1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UCHL1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4