Aliases for UCA1 Gene
Subcategory (RNA class) for UCA1 Gene
non-coding RNA
Quality Score for this RNA gene is
13
Aliases for UCA1 Gene
External Ids for UCA1 Gene
- HGNC: 37126
- Entrez Gene: 652995
- Ensembl: ENSG00000214049
- OMIM: 617500
Previous GeneCards Identifiers for UCA1 Gene
- GC19U900573
- GC19P015939
- GC19P015511
Summaries for UCA1 Gene
-
This gene produces a long non-coding RNA that was found to be upregulated in bladder cancer and plays a regulatory role in cell proliferation. This transcript regulates several genes, including CREB (cAMP responsive element binding protein). Expression of this transcript is regulated by CCAAT/enhancer-binding protein-alpha. [provided by RefSeq, Dec 2017]
GeneCards Summary for UCA1 Gene
UCA1 (Urothelial Cancer Associated 1 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with UCA1 include Bladder Cancer. Among its related pathways are LncRNA-mediated mechanisms of therapeutic resistance.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCA1 Gene
Genomics for UCA1 Gene
GeneHancer (GH) Regulatory Elements for UCA1 Gene
Promoters and enhancers for UCA1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH19I015826 | Promoter/Enhancer | 2.3 | FANTOM5 Ensembl ENCODE dbSUPER | 16.3 | +3.8 | 3818 | 12.9 | HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 | ENSG00000273782 AKAP8 MED26 ENSG00000269578 BRD4 CYP4F24P UCA1 OR10H4 CHERP OR10H5 | |
| GH19I015844 | Enhancer | 1.1 | ENCODE dbSUPER | 8.3 | +15.7 | 15714 | 1 | HDAC1 PKNOX1 ATF1 ARNT ZBTB40 TCF12 ZNF766 GATA2 ETV6 ATF7 | GC19M015845 CYP4F24P UCA1 GC19M015836 | |
| GH19I015824 | Enhancer | 0.7 | dbSUPER | 10.6 | -4.0 | -3991 | 1.7 | ETV1 BACH1 PYGO2 ZNF644 ZBTB40 ZNF507 RELA IRF9 ZNF766 NFE2 | GC19P015826 ZNF861P CYP4F24P AKAP8 CHERP ENSG00000267904 C19orf44 ENSG00000269578 OR10H5 ENSG00000268087 | |
| GH19I015841 | Enhancer | 0.5 | dbSUPER | 7.2 | +13.4 | 13396 | 0.9 | CTCF REST ZBTB33 ZKSCAN1 | UCA1 CYP4F11 GC19M015845 GC19M015836 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around UCA1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for UCA1 Gene
Genomic Locations for UCA1 Gene
- chr19:15,828,947-15,836,321
- (GRCh38/hg38)
- Size:
- 7,375 bases
- Orientation:
- Plus strand
- chr19:15,939,757-15,947,130
- (GRCh37/hg19)
Genomic View for UCA1 Gene
Genes around UCA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.12 by Ensembl
- 19p13.12 by Entrez Gene
- 19p13.12 by HGNC
UCA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UCA1 Gene
Proteins for UCA1 Gene
-
Protein details for UCA1 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- Q2VCE5
- Recommended name:
- UCA1 protein
- Protein Accession:
- Q2VCE5
Protein attributes for UCA1 Gene
- Size:
- 60 amino acids
- Molecular mass:
- 6544 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for UCA1 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for UCA1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for UCA1
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- Search GeneTex for Proteins for UCA1
No data available for DME Specific Peptides for UCA1 Gene
Domains & Families for UCA1 Gene
Gene Families for UCA1 Gene
Protein Domains for UCA1 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for UCA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for UCA1 Gene
Function for UCA1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
- Search ViGene Biosciences for UCA1
CRISPR Products
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- Applied Biological Materials CRISPR for UCA1
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA for UCA1 Gene
- miRTarBase miRNAs that target UCA1
miRNA Products
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Inhibitory RNA Products
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Clone Products
- GenScript: Custom all cDNA clones Services for UCA1
- VectorBuilder custom plasmid, inducible vectors for UCA1
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for UCA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UCA1 Gene
Localization for UCA1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for UCA1 Gene
Pathways & Interactions for UCA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | LncRNA-mediated mechanisms of therapeutic resistance | ||
Pathways by source for UCA1 Gene
1 BioSystems pathway for UCA1 Gene
Interacting Proteins for UCA1 Gene
No data available for SIGNOR curated interactions for UCA1 Gene
Transcripts for UCA1 Gene
mRNA/cDNA for UCA1 Gene
- (20) Additional mRNA sequences :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for UCA1 Gene
CRISPR Products
- Browse CRISPR knockouts for UCA1
- Applied Biological Materials CRISPR for UCA1
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for UCA1
Inhibitory RNA Products
- Search ViGene Biosciences for UCA1
Clone Products
- GenScript: Custom all cDNA clones Services for UCA1
- VectorBuilder custom plasmid, inducible vectors for UCA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for UCA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for UCA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for UCA1 Gene
mRNA differential expression in normal tissues according to GTEx for UCA1 Gene
This gene is overexpressed in Bladder (x23.4) and Cervix - Endocervix (x8.6).
NURSA nuclear receptor signaling pathways regulating expression of UCA1 Gene:
UCA1SOURCE GeneReport for Unigene cluster for UCA1 Gene:
Hs.644234Primer Products
-
OriGene qPCR primer pairs for UCA1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UCA1 Gene
Orthologs for UCA1 Gene
No data available for Orthologs for UCA1 Gene
Paralogs for UCA1 Gene
No data available for Paralogs for UCA1 Gene
Variants for UCA1 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000154015 | -- | 15,832,624(+) | C/T | intron_variant | |
| rs1000178231 | -- | 15,834,944(+) | A/G | non_coding_transcript_variant | |
| rs1000267710 | -- | 15,827,226(+) | T/G | upstream_transcript_variant | |
| rs1000476101 | -- | 15,836,794(+) | G/A | downstream_transcript_variant | |
| rs1000488880 | -- | 15,834,055(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2671181 | CNV | deletion | 23128226 |
| esv2718244 | CNV | deletion | 23290073 |
| esv3334671 | CNV | duplication | 20981092 |
| nsv1064684 | CNV | gain | 25217958 |
| nsv1133007 | OTHER | inversion | 24896259 |
| nsv833766 | CNV | loss | 17160897 |
| nsv960799 | CNV | duplication | 23825009 |
Additional Variant Information for UCA1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- UCA1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for UCA1 Gene
Disorders for UCA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bladder cancer |
|
|
Search UCA1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for UCA1
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for UCA1 Gene
Publications for UCA1 Gene
- lncRNA UCA1 Contributes to Imatinib Resistance by Acting as a ceRNA Against miR-16 in Chronic Myeloid Leukemia Cells. (PMID: 27854515) Xiao Y … Zhang Z (DNA and cell biology 2017) 2 3 58
- Analysis of long non-coding RNA expression profiles in gastric cancer. (PMID: 23801869) Cao WJ … Zhang ZY (World journal of gastroenterology 2013) 2 3 58
- UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. (PMID: 18501714) Wang F … Chen W (FEBS letters 2008) 2 3 58
- Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. (PMID: 17416635) Tsang WP … Kwok TT (RNA (New York, N.Y.) 2007) 2 3 58
- LncRNA UCA1 modulates cardiomyocyte apoptosis by targeting miR-143 in myocardial ischemia-reperfusion injury. (PMID: 28916071) Yu SY … Tang L (International journal of cardiology 2017) 3 58
Products for UCA1 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for UCA1
- VectorBuilder custom plasmid, inducible vectors for UCA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for UCA1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for UCA1
- Search GeneTex for Proteins for UCA1
- Search ViGene Biosciences for UCA1
Sources for UCA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
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- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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- (114) diseasecard
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- (147) Gene ORGANizer
- (148) abm
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- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew