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Aliases for UCA1 Gene

Subcategory (RNA class) for UCA1 Gene

lncRNA

Quality Score for this RNA gene is

3

Aliases for UCA1 Gene

  • Urothelial Cancer Associated 1 (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 178 2 3
  • Cancer Up-Regulated Drug Resistant 2 3
  • NCRNA00178 3
  • LINC00178 3
  • GUCA1B 6
  • UCAT1 3
  • GCAP2 6
  • GUCA2 6
  • CUDR 3
  • RP48 6

External Ids for UCA1 Gene

Summaries for UCA1 Gene

Entrez Gene Summary for UCA1 Gene

  • This gene represents a long non-coding RNA. It plays a regulatory role in bladder cancer cell proliferation. Several genes can be regulated by this gene, and the most important one is the CREB (cAMP responsive element binding protein) gene, which encodes a transcriptional factor and affects the oncogenesis. [provided by RefSeq, Mar 2012]

GeneCards Summary for UCA1 Gene

UCA1 (Urothelial Cancer Associated 1 (Non-Protein Coding)) is an RNA Gene, and belongs to the lncRNA class. Diseases associated with UCA1 include retinitis pigmentosa 48. Among its related pathways are Signaling by GPCR and Disease.

fRNAdb sequence ontologies for UCA1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • ncRNA: An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

  • mature_transcript: A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for UCA1 Gene

Genomics for UCA1 Gene

Genomic Location for UCA1 Gene

Start:
15,828,947 bp from pter
End:
15,836,321 bp from pter
Size:
7,375 bases
Orientation:
Plus strand

Genomic View for UCA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UCA1 Gene

No data available for Regulatory Elements for UCA1 Gene

Proteins for UCA1 Gene

  • Protein details for UCA1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q2VCE5-Q2VCE5
    Recommended name:
    UCA1 protein
    Protein Accession:
    Q2VCE5
    Secondary Accessions:

    Protein attributes for UCA1 Gene

    Size:
    60 amino acids
    Molecular mass:
    6544 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UCA1 Gene

Proteomics data for UCA1 Gene at MOPED

Post-translational modifications for UCA1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for UCA1 Gene

Domains for UCA1 Gene

Gene Families for UCA1 Gene

HGNC:
  • LNCRNA :Long non-coding RNAs

Protein Domains for UCA1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for UCA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UCA1: view

No data available for UniProtKB/Swiss-Prot for UCA1 Gene

Function for UCA1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UCA1 Gene

Localization for UCA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UCA1 Gene COMPARTMENTS Subcellular localization image for UCA1 gene
Compartment Confidence
extracellular 2
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UCA1 Gene

Transcripts for UCA1 Gene

mRNA/cDNA for UCA1 Gene

(20) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UCA1 Gene

Urothelial cancer associated 1 (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UCA1 Gene

No ASD Table

Relevant External Links for UCA1 Gene

GeneLoc Exon Structure for
UCA1
ECgene alternative splicing isoforms for
UCA1

Expression for UCA1 Gene

mRNA expression in normal human tissues for UCA1 Gene

mRNA differential expression in normal tissues according to GTEx for UCA1 Gene

This gene is overexpressed in Bladder (23.4) and Cervix - Endocervix (8.6).

SOURCE GeneReport for Unigene cluster for UCA1 Gene Hs.644234

genes like me logo Genes that share expressions with UCA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for UCA1 Gene

Orthologs for UCA1 Gene

Evolution for UCA1 Gene

ENSEMBL:
Gene Tree for UCA1 (if available)
TreeFam:
Gene Tree for UCA1 (if available)

No data available for Orthologs for UCA1 Gene

Paralogs for UCA1 Gene

No data available for Paralogs for UCA1 Gene

Variants for UCA1 Gene

Sequence variations from dbSNP and Humsavar for UCA1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2490 -- 15,834,575(-) tgagg(C/T)tgtag nc-transcript-variant
rs13896 -- 15,835,325(-) TTTCC(A/G)TCATA nc-transcript-variant
rs14366 -- 15,835,209(-) TGCAG(A/G)AGAGA nc-transcript-variant
rs916957 -- 15,836,407(+) ATGTG(A/G)ATTGC downstream-variant-500B
rs1319147 -- 15,836,790(+) GAGGA(C/T)CGAGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for UCA1 Gene

Variant ID Type Subtype PubMed ID
nsv911139 CNV Gain 21882294
esv2718244 CNV Deletion 23290073
nsv833766 CNV Loss 17160897
esv2671181 CNV Deletion 23128226

Relevant External Links for UCA1 Gene

HapMap Linkage Disequilibrium report
UCA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UCA1 Gene

Disorders for UCA1 Gene

(1) OMIM Diseases for UCA1 Gene (602275)

(1) MalaCards Diseases for UCA1 Gene

Search for UCA1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for UCA1 Gene

Relevant External Links for UCA1

Human Genome Epidemiology (HuGE) Navigator
UCA1
genes like me logo Genes that share disorders with UCA1: view

No data available for UniProtKB/Swiss-Prot for UCA1 Gene

Publications for UCA1 Gene

  1. Analysis of long non-coding RNA expression profiles in gastric cancer. (PMID: 23801869) Cao W.J. … Zhang Z.Y. (World J. Gastroenterol. 2013) 2 3
  2. Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. (PMID: 17416635) Tsang W.P. … Kwok T.T. (RNA 2007) 2 3
  3. UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. (PMID: 18501714) Wang F. … Chen W. (FEBS Lett. 2008) 2 3
  4. [Cellular localization and tissue expression pattern of UCA1, a non-coding RNA]. (PMID: 20117985) Xie X.J. … Chen W. (Nan Fang Yi Ke Da Xue Xue Bao 2010) 3
  5. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PMID: 22118674) Altun M. … Kessler B.M. (Chem. Biol. 2011) 3

Products for UCA1 Gene

Sources for UCA1 Gene

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