Aliases for UCA1 Gene
Subcategory (RNA class) for UCA1 Gene
non-coding RNA
Quality Score for this RNA gene is
3
Aliases for UCA1 Gene
External Ids for UCA1 Gene
- HGNC: 37126
- Entrez Gene: 652995
- Ensembl: ENSG00000214049
Previous GeneCards Identifiers for UCA1 Gene
- GC19U900573
- GC19P015939
- GC19P015511
Summaries for UCA1 Gene
-
This gene represents a long non-coding RNA. It plays a regulatory role in bladder cancer cell proliferation. Several genes can be regulated by this gene, and the most important one is the CREB (cAMP responsive element binding protein) gene, which encodes a transcriptional factor and affects the oncogenesis. [provided by RefSeq, Mar 2012]
GeneCards Summary for UCA1 Gene
UCA1 (Urothelial Cancer Associated 1 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Among its related pathways are LncRNA-mediated mechanisms of therapeutic resistance.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UCA1 Gene
Genomics for UCA1 Gene
Regulatory Elements for UCA1 Gene
Enhancers for UCA1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH19G015826 | 2 | FANTOM5 Ensembl ENCODE dbSUPER | 16.3 | +3.8 | 3818 | 12.9 | HDGF PKNOX1 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 | ENSG00000269578 AKAP8 CYP4F24P UCA1 OR10H4 OR10H5 ENSG00000268087 CYP4F12 CYP4F11 ENSG00000267904 |
| GH19G015844 | 1.2 | ENCODE dbSUPER | 8.3 | +15.7 | 15714 | 1.0 | PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 NCOA1 MEF2D MBD2 SMARCA4 | CYP4F24P UCA1 GC19M015845 GC19M015836 |
| GH19G015824 | 0.9 | dbSUPER | 10.6 | -4.0 | -3991 | 1.7 | PKNOX1 NFIB ARID4B ZNF48 YY1 ZNF766 KLF13 THAP11 ZBTB11 NFYC | CYP4F24P OR10H5 CYP4F11 OR10H4 UCA1 GC19P015826 ZNF861P |
| GH19G015841 | 0.5 | dbSUPER | 7.2 | +13.4 | 13397 | 0.9 | CTCF ZBTB33 REST ZBTB7A ZKSCAN1 | UCA1 CYP4F11 GC19M015845 GC19M015836 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around UCA1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for UCA1 Gene
- Chromosome:
- 19
- Start:
- 15,828,947 bp from pter
- End:
- 15,836,321 bp from pter
- Size:
- 7,375 bases
- Orientation:
- Plus strand
Genomic View for UCA1 Gene
Genes around UCA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.12 by Ensembl
- 19p13.12 by Entrez Gene
- 19p13.12 by HGNC
UCA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UCA1 Gene
Proteins for UCA1 Gene
-
Protein details for UCA1 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- Q2VCE5
- Recommended name:
- UCA1 protein
- Protein Accession:
- Q2VCE5
Protein attributes for UCA1 Gene
- Size:
- 60 amino acids
- Molecular mass:
- 6544 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for UCA1 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for UCA1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for UCA1
- Origene Custom Protein Services for UCA1
- Search GeneTex for Proteins for UCA1
No data available for DME Specific Peptides for UCA1 Gene
Domains & Families for UCA1 Gene
Gene Families for UCA1 Gene
Protein Domains for UCA1 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for UCA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for UCA1 Gene
Function for UCA1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for UCA1
-
- Search ViGene Biosciences for UCA1
CRISPR Products
- Browse CRISPR knockouts for UCA1
miRNA Products
- Search ViGene Biosciences for UCA1
Inhibitory RNA Products
- Search ViGene Biosciences for UCA1
Clone Products
- GenScript: Custom all cDNA clones Services for UCA1
- VectorBuilder custom plasmid, inducible vectors for UCA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for UCA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UCA1 Gene
Localization for UCA1 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for UCA1 Gene
Pathways & Interactions for UCA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | LncRNA-mediated mechanisms of therapeutic resistance | ||
Pathways by source for UCA1 Gene
1 BioSystems pathway for UCA1 Gene
Interacting Proteins for UCA1 Gene
No data available for SIGNOR curated interactions for UCA1 Gene
Transcripts for UCA1 Gene
mRNA/cDNA for UCA1 Gene
- (20) Additional mRNA sequences :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for UCA1 Gene
CRISPR Products
- Browse CRISPR knockouts for UCA1
miRNA Products
- Search ViGene Biosciences for UCA1
Inhibitory RNA Products
- Search ViGene Biosciences for UCA1
Clone Products
- GenScript: Custom all cDNA clones Services for UCA1
- VectorBuilder custom plasmid, inducible vectors for UCA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for UCA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for UCA1 Gene
mRNA differential expression in normal tissues according to GTEx for UCA1 Gene
This gene is overexpressed in Bladder (x23.4) and Cervix - Endocervix (x8.6).
NURSA nuclear receptor signaling pathways regulating expression of UCA1 Gene:
UCA1SOURCE GeneReport for Unigene cluster for UCA1 Gene:
Hs.644234Primer Products
-
OriGene qPCR primer pairs for UCA1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UCA1 Gene
Orthologs for UCA1 Gene
No data available for Orthologs for UCA1 Gene
Paralogs for UCA1 Gene
No data available for Paralogs for UCA1 Gene
Variants for UCA1 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000154015 | -- | 15,832,624(+) | CCTTT(C/T)CCCAT | intron-variant | |
| rs1000178231 | -- | 15,834,944(+) | TCCAC(A/G)CCCAA | intron-variant, nc-transcript-variant | |
| rs1000267710 | -- | 15,827,226(+) | CACTC(G/T)GGAAA | upstream-variant-2KB, splice-acceptor-variant | |
| rs1000476101 | -- | 15,836,794(+) | ACCGA(A/G)GGCCG | downstream-variant-500B, upstream-variant-2KB | |
| rs1000488880 | -- | 15,834,055(+) | TTCAC(C/T)GGATG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2671181 | CNV | deletion | 23128226 |
| esv2718244 | CNV | deletion | 23290073 |
| esv3334671 | CNV | duplication | 20981092 |
| nsv1064684 | CNV | gain | 25217958 |
| nsv1133007 | OTHER | inversion | 24896259 |
| nsv833766 | CNV | loss | 17160897 |
| nsv960799 | CNV | duplication | 23825009 |
Relevant External Links for UCA1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- UCA1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for UCA1 Gene
Disorders for UCA1 Gene
Relevant External Links for UCA1
No disorders were found for UCA1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UCA1 Gene
Publications for UCA1 Gene
- lncRNA UCA1 Contributes to Imatinib Resistance by Acting as a ceRNA Against miR-16 in Chronic Myeloid Leukemia Cells. (PMID: 27854515) Xiao Y. … Zhang Z. (DNA Cell Biol. 2016) 2 3 64
- Analysis of long non-coding RNA expression profiles in gastric cancer. (PMID: 23801869) Cao W.J. … Zhang Z.Y. (World J. Gastroenterol. 2013) 2 3 64
- UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. (PMID: 18501714) Wang F. … Chen W. (FEBS Lett. 2008) 2 3 64
- Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. (PMID: 17416635) Tsang W.P. … Kwok T.T. (RNA 2007) 2 3 64
- Expression of Long Noncoding RNA Urothelial Cancer Associated 1 Promotes Cisplatin Resistance in Cervical Cancer. (PMID: 28414550) Wang B. … Zhou S. (Cancer Biother. Radiopharm. 2017) 3 64
Products for UCA1 Gene
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- Browse R&D Systems for biochemical assays
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- OriGene qPCR primer pairs for UCA1
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Custom all cDNA clones Services for UCA1
- GenScript Custom Purified and Recombinant Proteins Services for UCA1
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- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Search GeneTex for Antibodies for UCA1
- Search GeneTex for Proteins for UCA1
- Search ViGene Biosciences for UCA1
- Cyagen custom Knockout/knockin (KOKI) mouse models for UCA1
- VectorBuilder custom plasmid, inducible vectors for UCA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for UCA1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for UCA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
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- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
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- (155) Gene ORGANizer