UBXN8 Gene
protein-coding GIFtS: 44
GCID: GC08P030601
|
|
UBX domain protein 8(Previous name: UBX domain containing 6 )
(Previous symbol: UBXD6)
| |
Aliases
for UBXN8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| UBX Domain Protein 81 2 | | Rep-8 Protein2 3 | | D8S2298E1 2 3 5 | | Reproduction 8 Protein2 3 | | REP81 2 3 5 | | UBX Domain-Containing Protein 62 3 | | UBXD61 2 3 | | Reproduction/Chromosome 82 | | UBX Domain Containing 61 2 | | UBX Domain-Containing Protein 82 |
Export aliases for UBXN8 gene to outside databasesPrevious GC identifers: GC08P030723 GC08P029148 |
Summaries
for UBXN8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBXN8_HUMAN, O00124Function: May play a role in reproduction
|
Genomic Views
for UBXN8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBXN8 gene promoter:
c-Fos GR p53 AP-1 ATF-2 GR-alpha c-Jun NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBXN8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBXN8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p12-p11.2 Ensembl cytogenetic band: 8p12 HGNC cytogenetic band: 8p12-p11.2UBXN8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P030601: view genomic region
(about GC identifiers)
Start:
|
30,589,764 bp from pter |
End:
|
30,624,522 bp from pter |
Size:
|
34,759 bases |
Orientation:
|
plus strand |
|
Proteins
for UBXN8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBXN8_HUMAN, O00124 (See
protein sequence)Recommended Name: UBX domain-containing protein 8 Size: 270 amino acids; 30541 Da
Secondary accessions: Q7Z6F2Alternative splicing: 3 isoforms: O00124-1 O00124-2 O00124-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UBXN8: NX_O00124
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00124
UBXN8 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_005662.1
Human Recombinant Protein Products:
UBXN8 Antibody Products:
Assay Products for UBXN8: |
Protein
Domains /
Families
for UBXN8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBXN8 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00124ProtoNet protein and cluster: O00124 1 Blocks protein family: IPB001012 UBX domain
UniProtKB/Swiss-Prot: UBXN8_HUMAN, O00124Similarity: Contains 1 UBX domain |
Function
for UBXN8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBXN8_HUMAN, O00124Function: May play a role in reproduction
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN8 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBXN8 (NM_005671) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBXN8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN8 |
1 GenomeRNAi human phenotype for UBXN8:
|
Pathways & Interactions
for UBXN8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBXN8
5 Interacting proteins for UBXN8 (O001243) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
UBXN8 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBXN8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBXN8
Search CenterWatch for drugs/clinical trials and news about UBXN8
|
Transcripts
for UBXN8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBXN8 gene: NM_005671.2 Unigene Cluster for UBXN8: UBX domain protein 8 Hs.153678 [show with all ESTs]Unigene Representative Sequence: D8376712 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000522735 ENST00000522968 ENST00000517341(uc003xii.3 uc010lvi.3 uc003xij.3)
ENST00000519246(uc011lbb.2) ENST00000523607 ENST00000518239 ENST00000518059
ENST00000521598 ENST00000520436 ENST00000265616 ENST00000380154 ENST00000341403
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN8 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBXN8 (NM_005671) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBXN8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN8 |
Additional cDNA sequence: AK296600.1 AY302140.1 BC020694.1 D83767.1 D83768.1 8 DOTS entries: DT.442436 DT.86854311 DT.100774668 DT.97838667 DT.101980189 DT.92422440 DT.100774666 DT.92422438 24/92 AceView cDNA sequences (see all 92): AA769389 AI380966 AI005235 AA826070 AW204267 BF061627 AW613009 AW474066 AA889069 AI382377 AA971769 H65217 AI824160 AA465216 AA552711 BQ019612 BE514761 BI825292 AW510654 AA887557 BU951446 AY302140 CD369022 BI828192
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for UBXN8 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | | | - | | | | | | - | | | | | | | | |
| SP2: | | | - | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UBXN8
|
Expression
for UBXN8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBXN8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTCAAATTC
About this image
Genevestigator expression for UBXN8
SOURCE GeneReport for Unigene cluster: Hs.153678
UniProtKB/Swiss-Prot: UBXN8_HUMAN, O00124Tissue specificity: Expressed abundantly in ovary and testis, and weakly in all other tissues tested
SABiosciences Custom PCR Arrays for UBXN8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBXN8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBXN8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBXN8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBXN8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN8 |
Orthologs
for UBXN8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for UBXN8 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for UBXN8 (if available)
TreeFam Gene Tree for UBXN8 (if available) |
Paralogs
for UBXN8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for UBXN8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBXN8 (30589764 - 30624522 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for UBXN8
3 CNVs: 100309 65102 59468
6 Indels: 82554 82555 95357 95358 82553 95356 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for UBXN8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 UBXN8 for disorders About MalaCards
UBXN8 for disorders About GeneDecksing
OMIM gene information: 602155
OMIM disorders: --
Export disorders for UBXN8 gene to outside databases
|
Publications
for UBXN8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBXN8 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with UBXN8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of Rep-8 (D8S2298E) in the human chromosome 8p11.2-p12. (PubMed id 9027507)1, 2, 3, 9 Yamabe Y.... Furuichi Y. (1997)
- The tissue-specific Rep8/UBXD6 tethers p97 to the endo plasmic reticulum membrane for degradation of misfolded proteins. (PubMed id 21949850)1, 3 Madsen L....Hartmann-Petersen R. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. (PubMed id 18775313)1 Alexandru G....Deshaies R.J. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for UBXN8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBXN8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBXN8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBXN8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBXN8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBXN8 gene:
Search GeneIP for patents involving UBXN8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBXN8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UBXN8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBXN8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBXN8 | | | OriGene Protein Over-expression Lysate for UBXN8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBXN8 | | OriGene 3'-UTR Clone for UBXN8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UBXN8 | | OriGene Custom Protein Services for UBXN8 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBXN8 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBXN8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBXN8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBXN8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBXN8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBXN8 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for UBXN8 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | UBXN8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN8 |
|  |  |  | | | | Search ThermoFisher Antibodies for UBXN8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN8 |
|
|
|
|
