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Aliases for UBXN8 Gene

Aliases for UBXN8 Gene

  • UBX Domain Protein 8 2 3
  • D8S2298E 3 4 6
  • REP8 3 4 6
  • UBX Domain-Containing Protein 6 3 4
  • Reproduction 8 Protein 3 4
  • Rep-8 Protein 3 4
  • UBXD6 3 4
  • UBX Domain-Containing Protein 8 3
  • Reproduction/Chromosome 8 3
  • UBX Domain Containing 6 2

External Ids for UBXN8 Gene

Previous Symbols for UBXN8 Gene

  • UBXD6

Summaries for UBXN8 Gene

Entrez Gene Summary for UBXN8 Gene

  • p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013]

GeneCards Summary for UBXN8 Gene

UBXN8 (UBX Domain Protein 8) is a Protein Coding gene.

UniProtKB/Swiss-Prot for UBXN8 Gene

  • Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN8 Gene

Genomics for UBXN8 Gene

Genomic Location for UBXN8 Gene

Start:
30,732,247 bp from pter
End:
30,767,006 bp from pter
Size:
34,760 bases
Orientation:
Plus strand

Genomic View for UBXN8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBXN8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN8 Gene

Regulatory Elements for UBXN8 Gene

Proteins for UBXN8 Gene

  • Protein details for UBXN8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00124-UBXN8_HUMAN
    Recommended name:
    UBX domain-containing protein 8
    Protein Accession:
    O00124
    Secondary Accessions:
    • Q7Z6F2

    Protein attributes for UBXN8 Gene

    Size:
    270 amino acids
    Molecular mass:
    30541 Da
    Quaternary structure:
    • Interacts with SYVN1 and VCP.

    Alternative splice isoforms for UBXN8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBXN8 Gene

Proteomics data for UBXN8 Gene at MOPED

Post-translational modifications for UBXN8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys104

No data available for DME Specific Peptides for UBXN8 Gene

Domains for UBXN8 Gene

Gene Families for UBXN8 Gene

HGNC:
  • UBXN :UBX domain containing

Protein Domains for UBXN8 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

UBXN8_HUMAN
Domain:
  • Contains 1 UBX domain.:
    • O00124
genes like me logo Genes that share domains with UBXN8: view

Function for UBXN8 Gene

Molecular function for UBXN8 Gene

UniProtKB/Swiss-Prot Function: Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction.

Gene Ontology (GO) - Molecular Function for UBXN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004523 RNA-DNA hybrid ribonuclease activity --
GO:0005515 protein binding IPI 21949850
genes like me logo Genes that share ontologies with UBXN8: view

Phenotypes for UBXN8 Gene

GenomeRNAi human phenotypes for UBXN8:
genes like me logo Genes that share phenotypes with UBXN8: view

miRNA for UBXN8 Gene

miRTarBase miRNAs that target UBXN8

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBXN8 Gene

Localization for UBXN8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN8 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBXN8 Gene COMPARTMENTS Subcellular localization image for UBXN8 gene
Compartment Confidence
extracellular 3
golgi apparatus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UBXN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030176 integral component of endoplasmic reticulum membrane IDA 21949850
genes like me logo Genes that share ontologies with UBXN8: view

Pathways for UBXN8 Gene

SuperPathways for UBXN8 Gene

No Data Available

Interacting Proteins for UBXN8 Gene

Selected Interacting proteins: O00124-UBXN8_HUMAN for UBXN8 Gene via I2D

Gene Ontology (GO) - Biological Process for UBXN8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization TAS 9027507
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 21949850
genes like me logo Genes that share ontologies with UBXN8: view

No data available for Pathways by source for UBXN8 Gene

Transcripts for UBXN8 Gene

Unigene Clusters for UBXN8 Gene

UBX domain protein 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for UBXN8 Gene

GeneLoc Exon Structure for
UBXN8
ECgene alternative splicing isoforms for
UBXN8

Expression for UBXN8 Gene

mRNA expression in normal human tissues for UBXN8 Gene

mRNA differential expression in normal tissues according to GTEx for UBXN8 Gene

This gene is overexpressed in Ovary (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for UBXN8 Gene

SOURCE GeneReport for Unigene cluster for UBXN8 Gene Hs.153678

mRNA Expression by UniProt/SwissProt for UBXN8 Gene

O00124-UBXN8_HUMAN
Tissue specificity: Expressed abundantly in ovary and testis, and weakly in all other tissues tested
genes like me logo Genes that share expressions with UBXN8: view

Orthologs for UBXN8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBXN8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBXN8 36
  • 99.38 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia UBXN8 36
  • 86.54 (n)
  • 82.22 (a)
dog
(Canis familiaris)
Mammalia UBXN8 36
  • 87.11 (n)
  • 85.16 (a)
mouse
(Mus musculus)
Mammalia Ubxn8 36
  • 80.79 (n)
  • 75.46 (a)
Ubxn8 16
rat
(Rattus norvegicus)
Mammalia Ubxn8 36
  • 80.74 (n)
  • 75.19 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn8 36
  • 52.93 (n)
  • 41.6 (a)
zebrafish
(Danio rerio)
Actinopterygii ubxn8 36
  • 52.73 (n)
  • 43.39 (a)
Species with no ortholog for UBXN8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBXN8 Gene

ENSEMBL:
Gene Tree for UBXN8 (if available)
TreeFam:
Gene Tree for UBXN8 (if available)

Paralogs for UBXN8 Gene

No data available for Paralogs for UBXN8 Gene

Variants for UBXN8 Gene

Sequence variations from dbSNP and Humsavar for UBXN8 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1056743 -- 30,766,471(+) CTTTC(A/G)AATCA utr-variant-3-prime
rs1469173 -- 30,742,858(-) AAACA(C/T)AATGC upstream-variant-2KB
rs1469174 -- 30,742,849(-) GCAGT(G/T)CCTGA upstream-variant-2KB
rs1469175 -- 30,742,787(-) TTGCA(A/G)AAGGC upstream-variant-2KB
rs1559528 -- 30,764,541(-) AGTCT(A/T)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBXN8 Gene

Variant ID Type Subtype PubMed ID
esv2554093 CNV Deletion 19546169
esv2736833 CNV Deletion 23290073
esv2665433 CNV Deletion 23128226
nsv819626 CNV Loss 19587683
esv23174 CNV Loss 19812545
nsv824588 CNV Loss 20364138

Relevant External Links for UBXN8 Gene

HapMap Linkage Disequilibrium report
UBXN8

Disorders for UBXN8 Gene

No disorders were found for UBXN8 Gene.

No data available for UniProtKB/Swiss-Prot for UBXN8 Gene

Publications for UBXN8 Gene

  1. Cloning and characterization of Rep-8 (D8S2298E) in the human chromosome 8p11.2-p12. (PMID: 9027507) Yamabe Y. … Furuichi Y. (Genomics 1997) 2 3 4 23
  2. The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins. (PMID: 21949850) Madsen L. … Hartmann-Petersen R. (PLoS ONE 2011) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. (PMID: 18775313) Alexandru G. … Deshaies R.J. (Cell 2008) 3

Products for UBXN8 Gene

Sources for UBXN8 Gene

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