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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBXN7 Gene

protein-coding   GIFtS: 43
GCID: GC03M196074

UBX Domain Protein 7

(Previous name: UBX domain containing 7)
(Previous symbol: UBXD7)
  Search for UBXN7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UBX Domain Protein 71 2
UBXD71 2 3
UBX Domain Containing 71 2
UBX Domain-Containing Protein 72
KIAA07943

External Ids:    HGNC: 291191   Entrez Gene: 260432   Ensembl: ENSG000001639607   UniProtKB: O948883   

Export aliases for UBXN7 gene to outside databases

Previous GC identifers: GC03M197564 GC03M193377


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UBXN7 Gene: 
UBXN7 (UBX domain protein 7) is a protein-coding gene. GO annotations related to this gene include ubiquitin binding and transcription factor binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_029928.13  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBXN7 gene promoter:
         USF1   Sp1   SREBP-1c   USF-1:USF-2   POU6F1 (c2)   SREBP-1b   AREB6   SREBP-1a   USF-1   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UBXN7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBXN7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

UBXN7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBXN7 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M196074:  view genomic region     (about GC identifiers)

Start:
196,074,533 bp from pter      End:
196,159,345 bp from pter
Size:
84,813 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBXN7_HUMAN, O94888 (See protein sequence)
Recommended Name: UBX domain-containing protein 7  
Size: 489 amino acids; 54862 Da
Sequence caution: Sequence=BAA34514.1; Type=Erroneous initiation; Sequence=BAC85247.1; Type=Miscellaneous
discrepancy; Note=Unlikely isoform. Aberrant splice sites;
3 PDB 3D structures from and Proteopedia for UBXN7:
1WJ4 (3D)        2DAL (3D)        2DLX (3D)    
Secondary accessions: D3DXB3 Q6ZP77 Q86X20 Q8N327

Explore the universe of human proteins at neXtProt for UBXN7: NX_O94888

Explore proteomics data for UBXN7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94888

  • UBXN7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBXN7 Protein Expression
    REFSEQ proteins: NP_056377.1  
    ENSEMBL proteins: 
     ENSP00000296328   ENSP00000397238   ENSP00000397256   ENSP00000371311   ENSP00000404778  
     ENSP00000440716  

    Human Recombinant Protein Products for UBXN7: 
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    Novus Biologicals UBXN7 Protein
    Novus Biologicals UBXN7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBXN7 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034098Cdc48p-Npl4p-Ufd1p AAA ATPase complex IDA18775313

    UBXN7 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for UBXN7 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBXN: UBX domain containing

    5 InterPro protein domains:
     IPR006577 UAS
     IPR017346 UCP037991_UAS/UBX
     IPR001012 UBX
     IPR012336 Thioredoxin-like_fold
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry O94888

    ProtoNet protein and cluster: O94888

    1 Blocks protein domain: IPB001012 UBX domain

    UniProtKB/Swiss-Prot: UBXN7_HUMAN, O94888
    Similarity: Contains 1 UBX domain


    UBXN7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18775313
    GO:0008134transcription factor binding IPI18775313
    GO:0031625ubiquitin protein ligase binding IDA18775313
    GO:0043130ubiquitin binding IDA18775313
         
    UBXN7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UBXN7:
     Decreased viability of wild-ty 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBXN7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for UBXN7 (O948881, 3 ENSP000002963284) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIF1AQ166651, 3, ENSP000003380184EBI-1993627,EBI-447269 I2D: score=2 STRING: ENSP00000338018
    AMFRQ9UKV53, ENSP000002906494I2D: score=2 STRING: ENSP00000290649
    BRWD1Q9NSI63, ENSP000003307534I2D: score=2 STRING: ENSP00000330753
    BRWD3Q6RI453, ENSP000003623724I2D: score=2 STRING: ENSP00000362372
    CUL1Q136163, ENSP000003268044I2D: score=2 STRING: ENSP00000326804
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBXN7

    Search CenterWatch for drugs/clinical trials and news about UBXN7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBXN7 gene: 
    NM_015562.1  

    Unigene Cluster for UBXN7:

    UBX domain protein 7
    Hs.518524  [show with all ESTs]
    Unigene Representative Sequence: NM_015562
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296328(uc003fwm.4 uc003fwn.4 uc010iae.3) ENST00000429160
    ENST00000428095 ENST00000381887 ENST00000413584 ENST00000493566(uc010iaf.3)
    ENST00000535858
    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate UBXN7 (see all 44):
    hsa-miR-3678-3p hsa-miR-140-5p hsa-miR-3164 hsa-miR-21* hsa-miR-300 hsa-miR-513a-5p hsa-miR-342-3p hsa-miR-3162-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBXN7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBXN7

    Additional mRNA sequence: 

    AB018337.1 AK026451.1 AK129880.1 AK303630.1 AK307899.1 AK308699.1 BC028986.1 BC047420.1 

    5 DOTS entries:

    DT.410328  DT.120867394  DT.100009447  DT.102830582  DT.120867374 

    24/106 AceView cDNA sequences (see all 106):

    BQ025369 BC028986 AK129880 BE672990 CK300642 Z44570 AB018337 AI652612 
    CA443879 BU790150 AW090129 AI806990 AI950237 AI027267 AI273693 CN479019 
    BU949681 AA922194 CR616203 AI140210 AA760647 BX327661 BU949140 BE799614 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBXN7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UBXN7 Expression
    About this image


    See UBXN7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBXN7

    SOURCE GeneReport for Unigene cluster: Hs.518524
        SABiosciences Custom PCR Arrays for UBXN7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBXN7 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubxn71 , 5 UBX domain protein 71, 5 91.62(n)1
    97.75(a)1
      16 (22.58 cM)5
    2241111  NM_177633.41  NP_808301.31 
     323322525 
    chicken
    (Gallus gallus)
    Aves UBXN71 UBX domain protein 7 80.78(n)
    89.98(a)
      424856  XM_422667.3  XP_422667.2 
    lizard
    (Anolis carolinensis)
    Reptilia UBXN76
    Uncharacterized protein
    88(a)
    1 ↔ 1
    3(30700251-30726744)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.145302 Xenopus laevis transcribed sequence with weak similarity more 77.91(n)    BJ057155.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147812 Danio rerio cDNA clone IMAGE7000482, partial cds 77.46(n)    BC063998.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG88921 CG8892 42.77(n)
    32.19(a)
      33719  NM_164607.2  NP_723035.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBX5(YDR330W)4 UBX (ubiquitin regulatory X) domain-containing protein more   --   4(1127872-1129374) 851930  NP_010617.1 


    ENSEMBL Gene Tree for UBXN7 (if available)
    TreeFam Gene Tree for UBXN7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1689 SNPs in UBXN7 are shown (see all 1689)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs111855251,2
    C,F,A,H--196080164(+) AAGTAT/CACATT 1 -- ds50017Minor allele frequency- C:0.07EA NS NA WA 648
    rs65833021,2
    C,A--196080358(+) TTCTTT/CTTTTT 1 -- ds50019Minor allele frequency- C:0.00NA WA CSA 16
    rs2020683841,2
    C--196080358(+) CTTCT-/CTTTTT 1 -- ds50010--------
    rs1404851481,2
    --196080520(+) ACCCAA/GGTAAT 1 -- ut310--------
    rs1445542661,2
    C--196080547(+) GAGACA/GGGGTT 1 -- ut310--------
    rs1816619501,2
    C--196080609(+) CACCTC/TCGCCT 1 -- ut310--------
    rs1869011151,2
    --196080649(+) CACCGC/TGCCCG 1 -- ut310--------
    rs98164591,2
    C,F--196080738(+) CTCCCT/CAGCTT 1 -- ut31 trp31Minor allele frequency- C:0.06WA 118
    rs1478482971,2
    C--196080864(+) AAAGAA/CACTTG 1 -- ut310--------
    rs764407551,2
    C,F--196080987(+) GCCTTT/CATATC 1 -- ut311Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for UBXN7 (196074533 - 196159345 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for UBXN7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726579CNV Deletion23290073
    esv2660436CNV Deletion23128226
    esv2672614CNV Deletion23128226
    esv32642CNV Loss17666407
    nsv878182CNV Loss21882294
    nsv878183CNV Loss21882294
    dgv5374n71CNV Gain21882294
    nsv878186CNV Gain21882294
    nsv469831CNV Complex16826518

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    UBXN7 for disorders           About MalaCards

    UBXN7 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: UBXN7 (1 document)

    Export disorders for UBXN7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBXN7 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with UBXN7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    2. UBXN7 docks on neddylated cullin complexes using its U IM motif and causes HIF1a accumulation. (PubMed id 22537386)1, 3 Bandau S....Alexandru G. (2012)
    3. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1, 2 Meierhofer D.... Kaiser P. (2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26043 HGNC: 29119 AceView: KIAA0794 Ensembl:ENSG00000163960 euGenes: HUgn26043
    ECgene: UBXN7 H-InvDB: UBXN7

    (According to HUGE)
    About This Section
    HUGE: KIAA0794

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBXN7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBXN7 gene:
    Search GeneIP for patents involving UBXN7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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