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Aliases for UBXN7 Gene

Aliases for UBXN7 Gene

  • UBX Domain Protein 7 2 3
  • UBX Domain Containing 7 2 3
  • UBXD7 3 4
  • UBX Domain-Containing Protein 7 3
  • KIAA0794 4

External Ids for UBXN7 Gene

Previous HGNC Symbols for UBXN7 Gene

  • UBXD7

Previous GeneCards Identifiers for UBXN7 Gene

  • GC03M197564
  • GC03M196074
  • GC03M193377

Summaries for UBXN7 Gene

GeneCards Summary for UBXN7 Gene

UBXN7 (UBX Domain Protein 7) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding and ubiquitin binding.

UniProtKB/Swiss-Prot for UBXN7 Gene

  • Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN7 Gene

Genomics for UBXN7 Gene

Regulatory Elements for UBXN7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBXN7 Gene

196,347,662 bp from pter
196,432,474 bp from pter
84,813 bases
Minus strand

Genomic View for UBXN7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBXN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN7 Gene

Proteins for UBXN7 Gene

  • Protein details for UBXN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UBX domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • D3DXB3
    • Q6ZP77
    • Q86X20
    • Q8N327

    Protein attributes for UBXN7 Gene

    489 amino acids
    Molecular mass:
    54862 Da
    Quaternary structure:
    • Interacts with neddylated CUL2, ubiquitinated HIF1A, and VCP/p97.
    • Sequence=BAA34514.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85247.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBXN7 Gene

neXtProt entry for UBXN7 Gene

Proteomics data for UBXN7 Gene at MOPED

Post-translational modifications for UBXN7 Gene

  • Ubiquitination at Lys14, Lys84, Lys99, Lys134, Lys151, Lys194, Lys221, and Lys440
  • Modification sites at PhosphoSitePlus

Other Protein References for UBXN7 Gene

No data available for DME Specific Peptides for UBXN7 Gene

Domains for UBXN7 Gene

Gene Families for UBXN7 Gene

  • UBXN :UBX domain containing

Protein Domains for UBXN7 Gene

Suggested Antigen Peptide Sequences for UBXN7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O94888
  • The UIM (ubiquitin-interacting motif) is required to engage the NEDD8 modification on cullins.
  • The UBX domain mediates interaction with VCP/p97.
  • The UBA domain is required for binding ubiquitinated-protein substrates.
  • Contains 1 UBA domain
  • Contains 1 UBX domain.
  • Contains 1 UIM (ubiquitin-interacting motif) domain
genes like me logo Genes that share domains with UBXN7: view

Function for UBXN7 Gene

Molecular function for UBXN7 Gene

UniProtKB/Swiss-Prot Function: Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.

Gene Ontology (GO) - Molecular Function for UBXN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18775313
GO:0008134 transcription factor binding IPI 18775313
GO:0031625 ubiquitin protein ligase binding IDA 18775313
GO:0043130 ubiquitin binding IDA 18775313
genes like me logo Genes that share ontologies with UBXN7: view

Phenotypes for UBXN7 Gene

genes like me logo Genes that share phenotypes with UBXN7: view

Animal Model Products

CRISPR Products

miRNA for UBXN7 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBXN7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBXN7 Gene

Localization for UBXN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN7 Gene

Subcellular locations from

Jensen Localization Image for UBXN7 Gene COMPARTMENTS Subcellular localization image for UBXN7 gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for UBXN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex IDA 18775313
genes like me logo Genes that share ontologies with UBXN7: view

Pathways for UBXN7 Gene

SuperPathways for UBXN7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN7 Gene


No data available for Pathways by source for UBXN7 Gene

Transcripts for UBXN7 Gene

Unigene Clusters for UBXN7 Gene

UBX domain protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBXN7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for UBXN7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN7 Gene

No ASD Table

Relevant External Links for UBXN7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBXN7 Gene

mRNA expression in normal human tissues for UBXN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBXN7 Gene

SOURCE GeneReport for Unigene cluster for UBXN7 Gene Hs.518524

genes like me logo Genes that share expressions with UBXN7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBXN7 Gene

Orthologs for UBXN7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBXN7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBXN7 35
  • 96.32 (n)
  • 95.71 (a)
(Bos Taurus)
Mammalia UBXN7 35
  • 94.75 (n)
  • 97.75 (a)
UBXN7 36
  • 97 (a)
(Canis familiaris)
Mammalia UBXN7 35
  • 95.09 (n)
  • 98.36 (a)
UBXN7 36
  • 98 (a)
(Mus musculus)
Mammalia Ubxn7 35
  • 91.62 (n)
  • 97.75 (a)
Ubxn7 16
Ubxn7 36
  • 98 (a)
(Monodelphis domestica)
Mammalia UBXN7 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia UBXN7 36
  • 84 (a)
(Gallus gallus)
Aves UBXN7 35
  • 80.78 (n)
  • 89.98 (a)
UBXN7 36
  • 90 (a)
(Anolis carolinensis)
Reptilia UBXN7 36
  • 88 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14530 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn7 35
  • 71.33 (n)
  • 80.43 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7180 35
(Danio rerio)
Actinopterygii Dr.14781 35
ubxn7 35
  • 70.16 (n)
  • 77.15 (a)
ubxn7 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8892 36
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBX5 36
  • 25 (a)
UBX5 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for UBXN7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBXN7 Gene

Gene Tree for UBXN7 (if available)
Gene Tree for UBXN7 (if available)

Paralogs for UBXN7 Gene

No data available for Paralogs for UBXN7 Gene

Variants for UBXN7 Gene

Sequence variations from dbSNP and Humsavar for UBXN7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2043 -- 196,356,041(-) CATGA(C/G)ATGTG utr-variant-3-prime
rs3973 -- 196,397,407(-) cagat(C/T)taaag intron-variant
rs10632 -- 196,355,373(-) AGAAG(A/G)GGCCA utr-variant-3-prime
rs1061414 -- 196,356,277(-) TGGCT(A/T)GATTC utr-variant-3-prime
rs1061415 -- 196,356,276(-) GGCTA(G/T)ATTCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBXN7 Gene

Variant ID Type Subtype PubMed ID
nsv878182 CNV Loss 21882294
nsv469831 CNV Complex 16826518
nsv878183 CNV Loss 21882294
esv32642 CNV Loss 17666407
esv2672614 CNV Deletion 23128226
esv2660436 CNV Deletion 23128226
esv2726579 CNV Deletion 23290073
dgv5374n71 CNV Gain 21882294
nsv878186 CNV Gain 21882294

Relevant External Links for UBXN7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN7 Gene

Disorders for UBXN7 Gene

Relevant External Links for UBXN7

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with UBXN7: view

No data available for UniProtKB/Swiss-Prot for UBXN7 Gene

Publications for UBXN7 Gene

  1. UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1I+ accumulation. (PMID: 22537386) Bandau S. … Alexandru G. (BMC Biol. 2012) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for UBXN7 Gene

Sources for UBXN7 Gene

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