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Aliases for UBXN7 Gene

Aliases for UBXN7 Gene

  • UBX Domain Protein 7 2 3 5
  • UBX Domain Containing 7 2 3
  • UBXD7 3 4
  • UBX Domain-Containing Protein 7 3
  • KIAA0794 4

External Ids for UBXN7 Gene

Previous HGNC Symbols for UBXN7 Gene

  • UBXD7

Previous GeneCards Identifiers for UBXN7 Gene

  • GC03M197564
  • GC03M196074
  • GC03M193377

Summaries for UBXN7 Gene

GeneCards Summary for UBXN7 Gene

UBXN7 (UBX Domain Protein 7) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding and ubiquitin binding.

UniProtKB/Swiss-Prot for UBXN7 Gene

  • Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.

Additional gene information for UBXN7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN7 Gene

Genomics for UBXN7 Gene

Regulatory Elements for UBXN7 Gene

Enhancers for UBXN7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H196079 1.4 ENCODE dbSUPER 45.2 +373.3 373337 4.4 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B UBXN7 SDHAP1 SDHAP2 ACAP2 SENP5 UBXN7-AS1 ENSG00000230732 MUC4 LINC00969 ENSG00000260261
GH03H196163 1.8 FANTOM5 Ensembl ENCODE dbSUPER 30.5 +289.7 289680 2.9 HDGF ARNT ZNF493 ARID4B YBX1 DMAP1 ZNF2 TCF12 SLC30A9 ZNF207 SDHAP1 SDHAP2 LINC00969 UBXN7 ENSG00000230732 RNU6ATAC24P ACAP2 ENSG00000226345 ENSG00000213358 RPS29P3
GH03H196337 1.9 FANTOM5 Ensembl ENCODE dbSUPER 24.9 +114.9 114919 4.4 HDGF PKNOX1 ATF1 ARNT SIN3A YY1 ZNF766 ELK1 ATF7 FOS TM4SF19 SDHAP1 LINC00969 UBXN7 ENSG00000260261 ENSG00000231443 ENSG00000271662 SDHAP2 PCYT1A UBXN7-AS1
GH03H196968 1.6 FANTOM5 ENCODE dbSUPER 24.3 -515.1 -515075 2.4 PKNOX1 SIN3A ZNF766 GLIS2 ZNF143 ZNF207 ATF7 RUNX3 REST SMARCB1 SDHAP1 LOC220729 LRCH3 UBXN7 ENSG00000234742 SENP5 RPL35A PIGZ NCBP2-AS1 UBXN7-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBXN7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for UBXN7 Gene

Genomic Locations for UBXN7 Gene
106,657 bases
Minus strand

Genomic View for UBXN7 Gene

Genes around UBXN7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN7 Gene

Proteins for UBXN7 Gene

  • Protein details for UBXN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UBX domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • D3DXB3
    • Q6ZP77
    • Q86X20
    • Q8N327

    Protein attributes for UBXN7 Gene

    489 amino acids
    Molecular mass:
    54862 Da
    Quaternary structure:
    • Interacts with neddylated CUL2, ubiquitinated HIF1A, and VCP/p97.
    • Sequence=BAA34514.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85247.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBXN7 Gene

neXtProt entry for UBXN7 Gene

Post-translational modifications for UBXN7 Gene

  • Ubiquitination at Lys84, Lys99, Lys134, posLast=151151, Lys194, Lys221, and posLast=440440
  • Modification sites at PhosphoSitePlus

Other Protein References for UBXN7 Gene

No data available for DME Specific Peptides for UBXN7 Gene

Domains & Families for UBXN7 Gene

Gene Families for UBXN7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBXN7 Gene

Suggested Antigen Peptide Sequences for UBXN7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The UIM (ubiquitin-interacting motif) is required to engage the NEDD8 modification on cullins.
  • The UIM (ubiquitin-interacting motif) is required to engage the NEDD8 modification on cullins.
  • The UBX domain mediates interaction with VCP/p97.
  • The UBA domain is required for binding ubiquitinated-protein substrates.
genes like me logo Genes that share domains with UBXN7: view

Function for UBXN7 Gene

Molecular function for UBXN7 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.

Phenotypes From GWAS Catalog for UBXN7 Gene

Gene Ontology (GO) - Molecular Function for UBXN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18775313
GO:0008134 transcription factor binding IPI 18775313
GO:0031625 ubiquitin protein ligase binding IDA 18775313
GO:0043130 ubiquitin binding IDA 18775313
genes like me logo Genes that share ontologies with UBXN7: view

Phenotypes for UBXN7 Gene

genes like me logo Genes that share phenotypes with UBXN7: view

Animal Model Products

CRISPR Products

miRNA for UBXN7 Gene

miRTarBase miRNAs that target UBXN7

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBXN7 Gene

Localization for UBXN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBXN7 gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UBXN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016604 nuclear body IDA --
GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex IDA 18775313
genes like me logo Genes that share ontologies with UBXN7: view

Pathways & Interactions for UBXN7 Gene

SuperPathways for UBXN7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with UBXN7: view

No data available for Pathways by source and SIGNOR curated interactions for UBXN7 Gene

Drugs & Compounds for UBXN7 Gene

No Compound Related Data Available

Transcripts for UBXN7 Gene

Unigene Clusters for UBXN7 Gene

UBX domain protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN7 Gene

No ASD Table

Relevant External Links for UBXN7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBXN7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBXN7 Gene

Protein differential expression in normal tissues from HIPED for UBXN7 Gene

This gene is overexpressed in Blymphocyte (7.6) and CD8 Tcells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBXN7 Gene

Protein tissue co-expression partners for UBXN7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBXN7 Gene:


SOURCE GeneReport for Unigene cluster for UBXN7 Gene:


Evidence on tissue expression from TISSUES for UBXN7 Gene

  • Nervous system(4.4)
  • Heart(4.3)
genes like me logo Genes that share expression patterns with UBXN7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBXN7 Gene

Orthologs for UBXN7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBXN7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBXN7 33
  • 96.32 (n)
(Canis familiaris)
Mammalia UBXN7 33 34
  • 95.09 (n)
(Bos Taurus)
Mammalia UBXN7 33 34
  • 94.75 (n)
(Monodelphis domestica)
Mammalia UBXN7 34
  • 94 (a)
(Mus musculus)
Mammalia Ubxn7 33 16 34
  • 91.62 (n)
(Ornithorhynchus anatinus)
Mammalia UBXN7 34
  • 84 (a)
(Gallus gallus)
Aves UBXN7 33 34
  • 80.78 (n)
(Anolis carolinensis)
Reptilia UBXN7 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn7 33
  • 71.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14530 33
(Danio rerio)
Actinopterygii ubxn7 33 34
  • 70.16 (n)
Dr.14781 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7180 33
fruit fly
(Drosophila melanogaster)
Insecta CG8892 34
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBX5 34 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
Species where no ortholog for UBXN7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBXN7 Gene

Gene Tree for UBXN7 (if available)
Gene Tree for UBXN7 (if available)

Paralogs for UBXN7 Gene

No data available for Paralogs for UBXN7 Gene

Variants for UBXN7 Gene

Sequence variations from dbSNP and Humsavar for UBXN7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000043919 -- 196,443,315(+) GGTGC(C/T)GTGGC intron-variant
rs1000057824 -- 196,381,977(+) AAGAA(A/G)TATGA intron-variant
rs1000087217 -- 196,394,631(+) TCTTA(A/C)TATCC intron-variant
rs1000118607 -- 196,421,942(+) GCCTG(C/T)AATCC intron-variant
rs1000142422 -- 196,450,835(+) CACCA(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBXN7 Gene

Variant ID Type Subtype PubMed ID
nsv997797 CNV gain 25217958
nsv469831 CNV gain 16826518
nsv1131756 CNV deletion 24896259
nsv1009811 CNV gain 25217958
nsv1003066 CNV gain 25217958
esv3599283 CNV loss 21293372
esv32642 CNV loss 17666407
esv2672614 CNV deletion 23128226
esv2660436 CNV deletion 23128226

Variation tolerance for UBXN7 Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBXN7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN7 Gene

Disorders for UBXN7 Gene

Relevant External Links for UBXN7

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBXN7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBXN7 Gene

Publications for UBXN7 Gene

  1. UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation. (PMID: 22537386) Bandau S … Alexandru G (BMC biology 2012) 2 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Crystal structures of the UBX domain of human UBXD7 and its complex with p97 ATPase. (PMID: 28274878) Li ZH … Jiang T (Biochemical and biophysical research communications 2017) 3 60

Products for UBXN7 Gene

Sources for UBXN7 Gene

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