UBXN7 Gene
protein-coding GIFtS: 45
GCID: GC03M196074
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UBX domain protein 7(Previous name: UBX domain containing 7 ) (Previous symbol: UBXD7)
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Aliases for UBXN7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| UBX Domain Protein 71 2 | | UBXD71 2 3 | | UBX Domain Containing 71 2 | | KIAA07941 3 | | UBX Domain-Containing Protein 72 |
Export aliases for UBXN7 gene to outside databasesPrevious GC identifers: GC03M197564 GC03M193377 |
Summaries for UBXN7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Views for UBXN7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_029928.13
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the UBXN7 gene promoter: USF1 Sp1 SREBP-1c USF-1:USF-2 POU6F1 (c2) SREBP-1b AREB6 SREBP-1a USF-1 NF-kappaB1 Other transcription factors
Search SABiosciences Chromatin IP Primers for UBXN7
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBXN7 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q29UBXN7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M196074: view genomic region
(about GC identifiers)
Start:
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196,074,533 bp from pter |
End:
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196,159,345 bp from pter |
Size:
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84,813 bases |
Orientation:
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minus strand |
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Proteins for UBXN7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: UBXN7_HUMAN, O94888 (See
protein sequence)Recommended Name: UBX domain-containing protein 7 Size: 489 amino acids; 54862 Da
Sequence caution: Sequence=BAA34514.1; Type=Erroneous initiation; Sequence=BAC85247.1; Type=Miscellaneous discrepancy;Note=Unlikely isoform. Aberrant splice sites;
3 PDB 3D structures from and Proteopedia for UBXN7:1WJ4 (3D)
  2DAL (3D)
  2DLX (3D)
 
Secondary accessions: D3DXB3 Q6ZP77 Q86X20 Q8N327Explore the universe of human proteins at neXtProt for UBXN7: NX_O94888
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O94888 UBXN7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056377.1 ENSEMBL proteins: ENSP00000296328 ENSP00000397238 ENSP00000397256 ENSP00000371311 ENSP00000404778 ENSP00000440716 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0034098 | Cdc48p-Npl4p-Ufd1p AAA ATPase complex |
IDA | 18775313 |
UBXN7 for ontologies About GeneDecksing
UBXN7 Antibody Products: Assay Products for UBXN7: |
Protein
Domains / Families for UBXN7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBXN7 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O94888ProtoNet protein and cluster: O94888 1 Blocks protein family: IPB001012 UBX domain
UniProtKB/Swiss-Prot: UBXN7_HUMAN, O94888Similarity: Contains 1 UBX domain |
Function for UBXN7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN7 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBXN7 (NM_015562) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBXN7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN7  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN7 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
UBXN7 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for UBXN7:
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Pathways & Interactions for UBXN7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBXN7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/46 Interacting proteins for UBXN7 (O948881, 3 ENSP000002963284) via UniProtKB, MINT, STRING, and/or I2D (see all 46)About this table
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Drugs & Compounds for UBXN7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for UBXN7 Search CenterWatch for drugs/clinical trials and news about UBXN7 
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Transcripts for UBXN7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for UBXN7 gene: NM_015562.1 Unigene Cluster for UBXN7: UBX domain protein 7 Hs.518524 [show with all ESTs]Unigene Representative Sequence: NM_0155627 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000296328(uc003fwm.4 uc003fwn.4 uc010iae.3) ENST00000429160 ENST00000428095 ENST00000381887 ENST00000413584 ENST00000493566(uc010iaf.3) ENST00000535858
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN7 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBXN7 (NM_015562) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBXN7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN7  |
Additional cDNA sequence: AB018337.1 AK026451.1 AK129880.1 AK303630.1 AK307899.1 AK308699.1 BC028986.1 BC047420.1 5 DOTS entries: DT.410328 DT.120867394 DT.100009447 DT.102830582 DT.120867374 24/106 AceView cDNA sequences (see all 106): CN479019 AI652612 AI806990 BU790150 AW090129 CR616203 BU949681 BQ025369 CK300642 AI027267 CA443879 AI950237 AK129880 Z44570 AA922194 AI273693 BC028986 BE672990 AB018337 BU949380 AK026451 BG392987 BX473161 BU857451 GeneLoc Exon Structure
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Expression for UBXN7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBXN7 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See UBXN7 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for UBXN7
SOURCE GeneReport for Unigene cluster: Hs.518524 SABiosciences Custom PCR Arrays for UBXN7
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBXN7 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBXN7 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBXN7 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBXN7 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN7 |
Orthologs for UBXN7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for UBXN7 gene from 8/26 species (see all 26) About this table
ENSEMBL Gene Tree for UBXN7 (if available) TreeFam Gene Tree for UBXN7 (if available)  |
Paralogs for UBXN7 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
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Genomic Variants for UBXN7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for UBXN7 (196074533 - 196159345 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for UBXN7 1 CNV: 7401 2 Inversions: 37243 0568  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBXN7 |
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Disorders
/ Diseases for UBXN7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBXN7 for disorders About GeneDecksing
1 disease for UBXN7: About MalaCardsmalaria Human Genome Epidemiology (HuGE) Navigator: UBXN7 (1 document) Export disorders for UBXN7 gene to outside databases
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Publications for UBXN7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBXN7 gene, integrated from 9 sources (see all 33): (articles sorted by number of sources associating them with UBXN7) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
- UBXN7 docks on neddylated cullin complexes using its U IM motif and causes HIF1a accumulation. (PubMed id 22537386)1, 3 Bandau S....Alexandru G. (2012)
- Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1, 2 Meierhofer D.... Kaiser P. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- NEDD8 links cullin-RING ubiquitin ligase function to t he p97 pathway. (PubMed id 22466964)1 den Besten W....Deshaies R.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
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External Searches for UBXN7 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing UBXN7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing UBXN7 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing UBXN7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for UBXN7 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for UBXN7 gene: Search GeneIP for patents involving UBXN7
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products for UBXN7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBXN7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBXN7 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for UBXN7 | | OriGene 3'-UTR Clone for UBXN7 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN7 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for UBXN7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for UBXN7 | | OriGene Custom Protein Services for UBXN7 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBXN7 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBXN7 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBXN7 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBXN7 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBXN7 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBXN7 |
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| | | Search Tocris compounds for UBXN7 |
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 | | UBXN7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN7 |
|  |  |  | | | Search ThermoFisher Antibodies for UBXN7 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN7 |
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