Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBXN7 Gene

Aliases for UBXN7 Gene

  • UBX Domain Protein 7 2 3 5
  • UBX Domain Containing 7 2 3
  • UBXD7 3 4
  • UBX Domain-Containing Protein 7 3
  • KIAA0794 4

External Ids for UBXN7 Gene

Previous HGNC Symbols for UBXN7 Gene

  • UBXD7

Previous GeneCards Identifiers for UBXN7 Gene

  • GC03M197564
  • GC03M196074
  • GC03M193377

Summaries for UBXN7 Gene

GeneCards Summary for UBXN7 Gene

UBXN7 (UBX Domain Protein 7) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding and ubiquitin binding.

UniProtKB/Swiss-Prot for UBXN7 Gene

  • Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN7 Gene

Genomics for UBXN7 Gene

Regulatory Elements for UBXN7 Gene


Enhancers around UBXN7 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBXN7 Gene

Chromosome:
3
Start:
196,347,662 bp from pter
End:
196,454,318 bp from pter
Size:
106,657 bases
Orientation:
Minus strand

Genomic View for UBXN7 Gene

Genes around UBXN7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN7 Gene

Proteins for UBXN7 Gene

  • Protein details for UBXN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94888-UBXN7_HUMAN
    Recommended name:
    UBX domain-containing protein 7
    Protein Accession:
    O94888
    Secondary Accessions:
    • D3DXB3
    • Q6ZP77
    • Q86X20
    • Q8N327

    Protein attributes for UBXN7 Gene

    Size:
    489 amino acids
    Molecular mass:
    54862 Da
    Quaternary structure:
    • Interacts with neddylated CUL2, ubiquitinated HIF1A, and VCP/p97.
    SequenceCaution:
    • Sequence=BAA34514.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85247.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBXN7 Gene

neXtProt entry for UBXN7 Gene

Post-translational modifications for UBXN7 Gene

  • Ubiquitination at Lys 84, Lys 99, Lys 134, Lys 151, Lys 194, Lys 221, and Lys 440
  • Modification sites at PhosphoSitePlus

Other Protein References for UBXN7 Gene

No data available for DME Specific Peptides for UBXN7 Gene

Domains & Families for UBXN7 Gene

Gene Families for UBXN7 Gene

Protein Domains for UBXN7 Gene

Suggested Antigen Peptide Sequences for UBXN7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94888

UniProtKB/Swiss-Prot:

UBXN7_HUMAN :
  • The UIM (ubiquitin-interacting motif) is required to engage the NEDD8 modification on cullins.
Domain:
  • The UIM (ubiquitin-interacting motif) is required to engage the NEDD8 modification on cullins.
  • The UBX domain mediates interaction with VCP/p97.
  • The UBA domain is required for binding ubiquitinated-protein substrates.
  • Contains 1 UBA domain.
  • Contains 1 UBX domain.
  • Contains 1 UIM (ubiquitin-interacting motif) domain.
genes like me logo Genes that share domains with UBXN7: view

Function for UBXN7 Gene

Molecular function for UBXN7 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.

Gene Ontology (GO) - Molecular Function for UBXN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18775313
GO:0008134 transcription factor binding IPI 18775313
GO:0031625 ubiquitin protein ligase binding IDA 18775313
GO:0043130 ubiquitin binding IDA 18775313
genes like me logo Genes that share ontologies with UBXN7: view

Phenotypes for UBXN7 Gene

genes like me logo Genes that share phenotypes with UBXN7: view

Animal Model Products

miRNA for UBXN7 Gene

miRTarBase miRNAs that target UBXN7

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBXN7 Gene

Localization for UBXN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBXN7 Gene COMPARTMENTS Subcellular localization image for UBXN7 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
cytosol 2

Gene Ontology (GO) - Cellular Components for UBXN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex IDA 18775313
genes like me logo Genes that share ontologies with UBXN7: view

Pathways & Interactions for UBXN7 Gene

SuperPathways for UBXN7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBXN7 Gene

Transcripts for UBXN7 Gene

Unigene Clusters for UBXN7 Gene

UBX domain protein 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN7 Gene

No ASD Table

Relevant External Links for UBXN7 Gene

GeneLoc Exon Structure for
UBXN7
ECgene alternative splicing isoforms for
UBXN7

Expression for UBXN7 Gene

mRNA expression in normal human tissues for UBXN7 Gene

Protein differential expression in normal tissues from HIPED for UBXN7 Gene

This gene is overexpressed in Blymphocyte (7.6) and CD8 Tcells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBXN7 Gene



Protein tissue co-expression partners for UBXN7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBXN7 Gene:

UBXN7

SOURCE GeneReport for Unigene cluster for UBXN7 Gene:

Hs.518524
genes like me logo Genes that share expression patterns with UBXN7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBXN7 Gene

Orthologs for UBXN7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBXN7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBXN7 34
  • 96.32 (n)
dog
(Canis familiaris)
Mammalia UBXN7 34 35
  • 95.09 (n)
cow
(Bos Taurus)
Mammalia UBXN7 34 35
  • 94.75 (n)
oppossum
(Monodelphis domestica)
Mammalia UBXN7 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubxn7 34 16 35
  • 91.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBXN7 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBXN7 34 35
  • 80.78 (n)
lizard
(Anolis carolinensis)
Reptilia UBXN7 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn7 34
  • 71.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14530 34
zebrafish
(Danio rerio)
Actinopterygii ubxn7 34 35
  • 70.16 (n)
Dr.14781 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7180 34
fruit fly
(Drosophila melanogaster)
Insecta CG8892 35
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBX5 35 37
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToOne
Species where no ortholog for UBXN7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBXN7 Gene

ENSEMBL:
Gene Tree for UBXN7 (if available)
TreeFam:
Gene Tree for UBXN7 (if available)

Paralogs for UBXN7 Gene

No data available for Paralogs for UBXN7 Gene

Variants for UBXN7 Gene

Sequence variations from dbSNP and Humsavar for UBXN7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10035374 -- 196,387,146(+) acaac(C/T)atctg intron-variant
rs10173981 -- 196,385,826(-) CCAGA(C/T)GGGGT intron-variant
rs10532490 -- 196,431,598(+) CGTCT(-/CC)GTCTT intron-variant, nc-transcript-variant
rs1061414 -- 196,356,277(-) TGGCT(A/T)GATTC utr-variant-3-prime
rs1061415 -- 196,356,276(-) GGCTA(G/T)ATTCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBXN7 Gene

Variant ID Type Subtype PubMed ID
esv2660436 CNV deletion 23128226
esv2672614 CNV deletion 23128226
esv32642 CNV loss 17666407
esv3599283 CNV loss 21293372
nsv1003066 CNV gain 25217958
nsv1009811 CNV gain 25217958
nsv1131756 CNV deletion 24896259
nsv469831 CNV gain 16826518
nsv997797 CNV gain 25217958

Variation tolerance for UBXN7 Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBXN7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBXN7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN7 Gene

Disorders for UBXN7 Gene

Relevant External Links for UBXN7

Human Genome Epidemiology (HuGE) Navigator
UBXN7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBXN7

No disorders were found for UBXN7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBXN7 Gene

Publications for UBXN7 Gene

  1. UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1I+ accumulation. (PMID: 22537386) Bandau S. … Alexandru G. (BMC Biol. 2012) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin. (PMID: 26826127) He J. … Wani A.A. (J. Biol. Chem. 2016) 3 64

Products for UBXN7 Gene

Sources for UBXN7 Gene

Content
Loading form....