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Aliases for UBXN6 Gene

Aliases for UBXN6 Gene

  • UBX Domain Protein 6 2 3
  • UBXD1 3 4 6
  • UBX Domain-Containing Protein 1 3 4
  • UBX Domain-Containing 1 2 3
  • UBX Domain Containing 1 2 3
  • UBXDC2 3 4
  • UBX Domain-Containing Protein 6 3
  • UBX Domain-Containing 2 3

External Ids for UBXN6 Gene

Previous HGNC Symbols for UBXN6 Gene

  • UBXD1

Previous GeneCards Identifiers for UBXN6 Gene

  • GC19M004397
  • GC19M004207

Summaries for UBXN6 Gene

GeneCards Summary for UBXN6 Gene

UBXN6 (UBX Domain Protein 6) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum.

UniProtKB/Swiss-Prot for UBXN6 Gene

  • Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN6 Gene

Genomics for UBXN6 Gene

Regulatory Elements for UBXN6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBXN6 Gene

4,444,999 bp from pter
4,457,822 bp from pter
12,824 bases
Minus strand

Genomic View for UBXN6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBXN6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN6 Gene

Proteins for UBXN6 Gene

  • Protein details for UBXN6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UBX domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • D6W626
    • Q96AH1
    • Q96IK9
    • Q9BZV0

    Protein attributes for UBXN6 Gene

    441 amino acids
    Molecular mass:
    49754 Da
    Quaternary structure:
    • Interacts with VCP through the PUB domain (via C-terminus) and VIM motif (via N-terminus). Interacts with SYVN1, HERPUD1, MDM2 and USP7. Interacts with VCPKMT.

    Alternative splice isoforms for UBXN6 Gene


neXtProt entry for UBXN6 Gene

Proteomics data for UBXN6 Gene at MOPED

Post-translational modifications for UBXN6 Gene

  • Ubiquitination at Lys85, Lys172, Lys202, Lys257, and Lys301
  • Modification sites at PhosphoSitePlus

Other Protein References for UBXN6 Gene

No data available for DME Specific Peptides for UBXN6 Gene

Domains for UBXN6 Gene

Gene Families for UBXN6 Gene

  • UBXN :UBX domain containing

Protein Domains for UBXN6 Gene

Suggested Antigen Peptide Sequences for UBXN6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BZV1
  • The UBX domain lacks key residues critical for VCP binding.
  • Contains 1 PUB (PUG) domain.
  • Contains 1 UBX domain.
genes like me logo Genes that share domains with UBXN6: view

Function for UBXN6 Gene

Molecular function for UBXN6 Gene

UniProtKB/Swiss-Prot Function: Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.

Gene Ontology (GO) - Molecular Function for UBXN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 18656546
genes like me logo Genes that share ontologies with UBXN6: view

Animal Model Products

CRISPR Products

miRNA for UBXN6 Gene

miRTarBase miRNAs that target UBXN6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBXN6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBXN6 Gene

Localization for UBXN6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN6 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes at the centrosome both in interphase and during mitosis.

Subcellular locations from

Jensen Localization Image for UBXN6 Gene COMPARTMENTS Subcellular localization image for UBXN6 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
endosome 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UBXN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton --
genes like me logo Genes that share ontologies with UBXN6: view

Pathways for UBXN6 Gene

genes like me logo Genes that share pathways with UBXN6: view

Pathways by source for UBXN6 Gene

1 KEGG pathway for UBXN6 Gene

Gene Ontology (GO) - Biological Process for UBXN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with UBXN6: view

Transcripts for UBXN6 Gene

Unigene Clusters for UBXN6 Gene

UBX domain protein 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBXN6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for UBXN6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP6: - -

Relevant External Links for UBXN6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBXN6 Gene

mRNA expression in normal human tissues for UBXN6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBXN6 Gene

This gene is overexpressed in Whole Blood (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBXN6 Gene

SOURCE GeneReport for Unigene cluster for UBXN6 Gene Hs.435255

mRNA Expression by UniProt/SwissProt for UBXN6 Gene

Tissue specificity: Enhanced expression in testis
genes like me logo Genes that share expressions with UBXN6: view

In Situ Assay Products

Orthologs for UBXN6 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBXN6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBXN6 35
  • 99.4 (n)
  • 99.74 (a)
UBXN6 36
  • 99 (a)
(Bos Taurus)
Mammalia UBXN6 35
  • 87.65 (n)
  • 87.95 (a)
UBXN6 36
  • 88 (a)
(Canis familiaris)
Mammalia UBXN6 35
  • 86.91 (n)
  • 87.34 (a)
UBXN6 36
  • 83 (a)
(Mus musculus)
Mammalia Ubxn6 35
  • 79.39 (n)
  • 81.14 (a)
Ubxn6 16
Ubxn6 36
  • 81 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
-- 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
-- 36
  • 48 (a)
(Rattus norvegicus)
Mammalia Ubxn6 35
  • 78.54 (n)
  • 81.93 (a)
(Gallus gallus)
Aves UBXN6 35
  • 64.35 (n)
  • 65.66 (a)
UBXN6 36
  • 63 (a)
(Anolis carolinensis)
Reptilia UBXN6 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn6 35
  • 58.53 (n)
  • 57.82 (a)
(Danio rerio)
Actinopterygii -- 35
ubxn6 35
  • 60.96 (n)
  • 56.48 (a)
ubxn6 36
  • 55 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006391 35
  • 53.81 (n)
  • 39.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gint3 35
  • 50.51 (n)
  • 38.64 (a)
Gint3 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea ubxn-6 35
  • 42.7 (n)
  • 34.54 (a)
ubxn-6 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for UBXN6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBXN6 Gene

Gene Tree for UBXN6 (if available)
Gene Tree for UBXN6 (if available)

Paralogs for UBXN6 Gene

Selected SIMAP similar genes for UBXN6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UBXN6: view

No data available for Paralogs for UBXN6 Gene

Variants for UBXN6 Gene

Sequence variations from dbSNP and Humsavar for UBXN6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11909 -- 4,454,003(-) GCTGC(C/T)GCCCT reference, synonymous-codon
rs243389 -- 4,446,998(-) AGCCG(A/G)GCCCC intron-variant
rs243390 -- 4,449,255(-) CCCTC(A/G)TCTGG intron-variant
rs243391 -- 4,449,811(-) CTCAG(C/T)TTTCT intron-variant
rs243392 -- 4,450,182(-) agtgg(C/T)gcaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBXN6 Gene

Variant ID Type Subtype PubMed ID
nsv910817 CNV Loss 21882294
nsv833718 CNV Loss 17160897
nsv910820 CNV Gain 21882294
dgv3674n71 CNV Loss 21882294
nsv910827 CNV Loss 21882294
nsv833720 CNV Loss 17160897
dgv3676n71 CNV Loss 21882294
dgv3677n71 CNV Loss 21882294
nsv910836 CNV Loss 21882294

Relevant External Links for UBXN6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN6 Gene

Disorders for UBXN6 Gene

No disorders were found for UBXN6 Gene.

No data available for UniProtKB/Swiss-Prot for UBXN6 Gene

Publications for UBXN6 Gene

  1. Identification and characterization of UBXD1, a novel UBX domain- containing gene on human chromosome 19p13, and its mouse ortholog. (PMID: 11342112) Carim-Todd L. … Sumoy L. (Biochim. Biophys. Acta 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4
  4. Ubxd1 is a novel co-factor of the human p97 ATPase. (PMID: 18656546) Madsen L. … Hartmann-Petersen R. (Int. J. Biochem. Cell Biol. 2008) 3 4
  5. The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors. (PMID: 21896481) Stapf C. … Buchberger A. (J. Biol. Chem. 2011) 3 4

Products for UBXN6 Gene

  • Addgene plasmids for UBXN6

Sources for UBXN6 Gene

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