Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBXN6 Gene

Aliases for UBXN6 Gene

  • UBX Domain Protein 6 2 3 5
  • UBX Domain-Containing Protein 1 3 4
  • UBX Domain-Containing 1 2 3
  • UBX Domain Containing 1 2 3
  • UBXDC2 3 4
  • UBXD1 3 4
  • UBX Domain-Containing 2 3

External Ids for UBXN6 Gene

Previous HGNC Symbols for UBXN6 Gene

  • UBXD1

Previous GeneCards Identifiers for UBXN6 Gene

  • GC19M004397
  • GC19M004207

Summaries for UBXN6 Gene

GeneCards Summary for UBXN6 Gene

UBXN6 (UBX Domain Protein 6) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. An important paralog of this gene is ASPSCR1.

UniProtKB/Swiss-Prot for UBXN6 Gene

  • Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN6 Gene

Genomics for UBXN6 Gene

Regulatory Elements for UBXN6 Gene

Promoters for UBXN6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBXN6 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBXN6 Gene

Chromosome:
19
Start:
4,444,999 bp from pter
End:
4,457,822 bp from pter
Size:
12,824 bases
Orientation:
Minus strand

Genomic View for UBXN6 Gene

Genes around UBXN6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN6 Gene

Proteins for UBXN6 Gene

  • Protein details for UBXN6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZV1-UBXN6_HUMAN
    Recommended name:
    UBX domain-containing protein 6
    Protein Accession:
    Q9BZV1
    Secondary Accessions:
    • D6W626
    • Q96AH1
    • Q96IK9
    • Q9BZV0

    Protein attributes for UBXN6 Gene

    Size:
    441 amino acids
    Molecular mass:
    49754 Da
    Quaternary structure:
    • Interacts with VCP through the PUB domain (via C-terminus) and VIM motif (via N-terminus). Interacts with SYVN1, HERPUD1, MDM2 and USP7. Interacts with VCPKMT.

    Alternative splice isoforms for UBXN6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBXN6 Gene

Proteomics data for UBXN6 Gene at MOPED

Post-translational modifications for UBXN6 Gene

  • Ubiquitination at Lys 172, Lys 202, Lys 257, and Lys 301
  • Modification sites at PhosphoSitePlus

Other Protein References for UBXN6 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for UBXN6

No data available for DME Specific Peptides for UBXN6 Gene

Domains & Families for UBXN6 Gene

Gene Families for UBXN6 Gene

Protein Domains for UBXN6 Gene

Suggested Antigen Peptide Sequences for UBXN6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZV1

UniProtKB/Swiss-Prot:

UBXN6_HUMAN :
  • The UBX domain lacks key residues critical for VCP binding.
Domain:
  • The UBX domain lacks key residues critical for VCP binding.
  • Contains 1 PUB (PUG) domain.
  • Contains 1 UBX domain.
genes like me logo Genes that share domains with UBXN6: view

Function for UBXN6 Gene

Molecular function for UBXN6 Gene

UniProtKB/Swiss-Prot Function:
Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.

Gene Ontology (GO) - Molecular Function for UBXN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with UBXN6: view
genes like me logo Genes that share phenotypes with UBXN6: view

Animal Model Products

CRISPR Products

miRNA for UBXN6 Gene

miRTarBase miRNAs that target UBXN6

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBXN6 Gene

Localization for UBXN6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN6 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes at the centrosome both in interphase and during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBXN6 Gene COMPARTMENTS Subcellular localization image for UBXN6 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 3
cytosol 2
endosome 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UBXN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with UBXN6: view

Pathways & Interactions for UBXN6 Gene

genes like me logo Genes that share pathways with UBXN6: view

Pathways by source for UBXN6 Gene

1 KEGG pathway for UBXN6 Gene

Gene Ontology (GO) - Biological Process for UBXN6 Gene

None

No data available for SIGNOR curated interactions for UBXN6 Gene

Drugs & Compounds for UBXN6 Gene

No Compound Related Data Available

Transcripts for UBXN6 Gene

Unigene Clusters for UBXN6 Gene

UBX domain protein 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6: - -
SP7:

Relevant External Links for UBXN6 Gene

GeneLoc Exon Structure for
UBXN6
ECgene alternative splicing isoforms for
UBXN6

Expression for UBXN6 Gene

mRNA expression in normal human tissues for UBXN6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBXN6 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for UBXN6 Gene

This gene is overexpressed in Frontal cortex (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBXN6 Gene



SOURCE GeneReport for Unigene cluster for UBXN6 Gene Hs.435255

mRNA Expression by UniProt/SwissProt for UBXN6 Gene

Q9BZV1-UBXN6_HUMAN
Tissue specificity: Enhanced expression in testis.
genes like me logo Genes that share expression patterns with UBXN6: view

Protein tissue co-expression partners for UBXN6 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for UBXN6 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBXN6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBXN6 35
  • 87.65 (n)
  • 87.95 (a)
UBXN6 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBXN6 35
  • 86.91 (n)
  • 87.34 (a)
UBXN6 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubxn6 35
  • 79.39 (n)
  • 81.14 (a)
Ubxn6 16
Ubxn6 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBXN6 35
  • 99.4 (n)
  • 99.74 (a)
UBXN6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubxn6 35
  • 78.54 (n)
  • 81.93 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
chicken
(Gallus gallus)
Aves UBXN6 35
  • 64.35 (n)
  • 65.66 (a)
UBXN6 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBXN6 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn6 35
  • 58.53 (n)
  • 57.82 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ubxn6 35
  • 60.96 (n)
  • 56.48 (a)
ubxn6 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006391 35
  • 53.81 (n)
  • 39.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gint3 35
  • 50.51 (n)
  • 38.64 (a)
Gint3 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ubxn-6 35
  • 42.7 (n)
  • 34.54 (a)
ubxn-6 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for UBXN6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBXN6 Gene

ENSEMBL:
Gene Tree for UBXN6 (if available)
TreeFam:
Gene Tree for UBXN6 (if available)

Paralogs for UBXN6 Gene

Paralogs for UBXN6 Gene

(1) SIMAP similar genes for UBXN6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UBXN6: view

Variants for UBXN6 Gene

Sequence variations from dbSNP and Humsavar for UBXN6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_047821 -
rs1127888 - 4,454,086(-) AAAAG(A/C/G)CCCAC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs243390 -- 4,449,255(-) CCCTC(A/G)TCTGG intron-variant
rs243391 -- 4,449,811(-) CTCAG(C/T)TTTCT intron-variant
rs243392 -- 4,450,182(-) agtgg(C/T)gcaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBXN6 Gene

Variant ID Type Subtype PubMed ID
nsv910817 CNV Loss 21882294
nsv833718 CNV Loss 17160897
nsv910820 CNV Gain 21882294
dgv3674n71 CNV Loss 21882294
nsv910827 CNV Loss 21882294
nsv833720 CNV Loss 17160897
dgv3676n71 CNV Loss 21882294
dgv3677n71 CNV Loss 21882294
nsv910836 CNV Loss 21882294

Variation tolerance for UBXN6 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.65; 78.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBXN6 Gene

HapMap Linkage Disequilibrium report
UBXN6
Human Gene Mutation Database (HGMD)
UBXN6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN6 Gene

Disorders for UBXN6 Gene

Relevant External Links for UBXN6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBXN6

No disorders were found for UBXN6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBXN6 Gene

Publications for UBXN6 Gene

  1. Identification and characterization of UBXD1, a novel UBX domain- containing gene on human chromosome 19p13, and its mouse ortholog. (PMID: 11342112) Carim-Todd L. … Sumoy L. (Biochim. Biophys. Acta 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase. (PMID: 23335559) Kirchner P. … Meyer H. (J. Biol. Chem. 2013) 3
  5. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3

Products for UBXN6 Gene

Sources for UBXN6 Gene

Back to Top

Content