Aliases for UBXN6 Gene
External Ids for UBXN6 Gene
Previous HGNC Symbols for UBXN6 Gene
Previous GeneCards Identifiers for UBXN6 Gene
GeneCards Summary for UBXN6 Gene
UBXN6 (UBX Domain Protein 6) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum.
UniProtKB/Swiss-Prot for UBXN6 Gene
May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622).