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Aliases for UBXN6 Gene

Aliases for UBXN6 Gene

  • UBX Domain Protein 6 2 3 5
  • UBX Domain-Containing Protein 1 3 4
  • UBX Domain Containing 1 2 3
  • UBXDC2 3 4
  • UBXD1 3 4
  • UBX Domain-Containing Protein 6 3
  • UBX Domain-Containing 2 3
  • UBX Domain-Containing 1 2
  • CTB-50L17.16 3

External Ids for UBXN6 Gene

Previous HGNC Symbols for UBXN6 Gene

  • UBXD1

Previous GeneCards Identifiers for UBXN6 Gene

  • GC19M004397
  • GC19M004207

Summaries for UBXN6 Gene

GeneCards Summary for UBXN6 Gene

UBXN6 (UBX Domain Protein 6) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. An important paralog of this gene is ASPSCR1.

UniProtKB/Swiss-Prot for UBXN6 Gene

  • Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN6 Gene

Genomics for UBXN6 Gene

Regulatory Elements for UBXN6 Gene

Enhancers for UBXN6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G004453 1.8 FANTOM5 ENCODE dbSUPER 26.4 +1.8 1763 5.1 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 CHAF1A ENSG00000267769 UBXN6 SH3GL1 APBA3 ENSG00000267030 CACTIN ENSG00000269807 MRPL54 ENSG00000267205
GH19G004388 1.5 Ensembl ENCODE dbSUPER 25 +66.1 66114 7.3 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 ZNF121 GATA2 ENSG00000267769 CHAF1A UBXN6 SH3GL1 MATK ENSG00000267980 PIR37989
GH19G004367 2 FANTOM5 Ensembl ENCODE dbSUPER 18.1 +83.0 83002 14.8 CREB3L1 MLX AGO1 DMAP1 ZNF143 ZNF263 NFYC TBX21 MEF2D SSRP1 ENSG00000267769 SEMA6B CHAF1A SH3GL1 UBXN6 CACTIN ENSG00000267030 FSD1 TMIGD2 ENSG00000267980
GH19G004398 1.4 ENCODE dbSUPER 25.6 +56.3 56250 6.8 CREB3L1 MLX AGO1 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 SP3 ENSG00000267769 CHAF1A UBXN6 CACTIN ENSG00000267980 CACTIN-AS1 SH3GL1
GH19G004445 1 ENCODE dbSUPER 27 +11.3 11301 2.8 AGO1 ZNF837 ZNF2 ZIC2 ZEB1 HIC1 GLIS2 POLR2A SCRT2 PATZ1 UBXN6 CHAF1A SH3GL1 MRPL54 ENSG00000267769 ENSG00000267030 MIR4746
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBXN6 on UCSC Golden Path with GeneCards custom track

Promoters for UBXN6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for UBXN6 Gene

4,444,999 bp from pter
4,457,822 bp from pter
12,824 bases
Minus strand

Genomic View for UBXN6 Gene

Genes around UBXN6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN6 Gene

Proteins for UBXN6 Gene

  • Protein details for UBXN6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UBX domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • D6W626
    • Q96AH1
    • Q96IK9
    • Q9BZV0

    Protein attributes for UBXN6 Gene

    441 amino acids
    Molecular mass:
    49754 Da
    Quaternary structure:
    • Interacts with VCP through the PUB domain (via C-terminus) and VIM motif (via N-terminus). Interacts with SYVN1, HERPUD1, MDM2 and USP7. Interacts with VCPKMT.

    Alternative splice isoforms for UBXN6 Gene


neXtProt entry for UBXN6 Gene

Post-translational modifications for UBXN6 Gene

  • Ubiquitination at Lys172, Lys202, posLast=257257, and isoforms=2301
  • Modification sites at PhosphoSitePlus

Other Protein References for UBXN6 Gene

No data available for DME Specific Peptides for UBXN6 Gene

Domains & Families for UBXN6 Gene

Gene Families for UBXN6 Gene

Protein Domains for UBXN6 Gene

Suggested Antigen Peptide Sequences for UBXN6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The UBX domain lacks key residues critical for VCP binding.
  • The UBX domain lacks key residues critical for VCP binding.
genes like me logo Genes that share domains with UBXN6: view

Function for UBXN6 Gene

Molecular function for UBXN6 Gene

UniProtKB/Swiss-Prot Function:
Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.

Gene Ontology (GO) - Molecular Function for UBXN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 18656546
genes like me logo Genes that share ontologies with UBXN6: view
genes like me logo Genes that share phenotypes with UBXN6: view

Animal Model Products

CRISPR Products

miRNA for UBXN6 Gene

miRTarBase miRNAs that target UBXN6

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBXN6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBXN6 Gene

Localization for UBXN6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN6 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes at the centrosome both in interphase and during mitosis.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBXN6 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 3
cytosol 2
endosome 2
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for UBXN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with UBXN6: view

Pathways & Interactions for UBXN6 Gene

genes like me logo Genes that share pathways with UBXN6: view

Pathways by source for UBXN6 Gene

1 KEGG pathway for UBXN6 Gene

Gene Ontology (GO) - Biological Process for UBXN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with UBXN6: view

No data available for SIGNOR curated interactions for UBXN6 Gene

Drugs & Compounds for UBXN6 Gene

No Compound Related Data Available

Transcripts for UBXN6 Gene

Unigene Clusters for UBXN6 Gene

UBX domain protein 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBXN6

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP6: - -

Relevant External Links for UBXN6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBXN6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBXN6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBXN6 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for UBXN6 Gene

This gene is overexpressed in Frontal cortex (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBXN6 Gene

Protein tissue co-expression partners for UBXN6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBXN6 Gene:


SOURCE GeneReport for Unigene cluster for UBXN6 Gene:


mRNA Expression by UniProt/SwissProt for UBXN6 Gene:

Tissue specificity: Enhanced expression in testis.

Evidence on tissue expression from TISSUES for UBXN6 Gene

  • Liver(4.3)
  • Skin(4.3)
  • Nervous system(3.6)
  • Eye(2.6)
  • Lung(2.4)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with UBXN6: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for UBXN6 Gene

Orthologs for UBXN6 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBXN6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBXN6 34 35
  • 99.4 (n)
(Bos Taurus)
Mammalia UBXN6 34 35
  • 87.65 (n)
(Canis familiaris)
Mammalia UBXN6 34 35
  • 86.91 (n)
(Mus musculus)
Mammalia Ubxn6 34 16 35
  • 79.39 (n)
(Rattus norvegicus)
Mammalia Ubxn6 34
  • 78.54 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
-- 35
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
-- 35
  • 48 (a)
(Gallus gallus)
Aves UBXN6 34 35
  • 64.35 (n)
(Anolis carolinensis)
Reptilia UBXN6 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn6 34
  • 58.53 (n)
(Danio rerio)
Actinopterygii ubxn6 34 35
  • 60.96 (n)
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006391 34
  • 53.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gint3 34 35
  • 50.51 (n)
(Caenorhabditis elegans)
Secernentea ubxn-6 34 35
  • 42.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
Species where no ortholog for UBXN6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBXN6 Gene

Gene Tree for UBXN6 (if available)
Gene Tree for UBXN6 (if available)

Paralogs for UBXN6 Gene

Paralogs for UBXN6 Gene

(1) SIMAP similar genes for UBXN6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UBXN6: view

Variants for UBXN6 Gene

Sequence variations from dbSNP and Humsavar for UBXN6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000017959 -- 4,448,271(+) GTGCT(A/G)GGATG intron-variant, nc-transcript-variant
rs1000034734 -- 4,444,649(+) ACCTT(C/T)CATCA intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1000147570 -- 4,444,820(+) CCTCC(A/C)CTAGC intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1000308323 -- 4,454,832(+) GCCAG(C/G)ACCCT intron-variant
rs1000317189 -- 4,448,149(+) AGGCC(C/T)AGCCC intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for UBXN6 Gene

Variant ID Type Subtype PubMed ID
nsv833718 CNV loss 17160897
nsv833720 CNV loss 17160897

Variation tolerance for UBXN6 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.65; 78.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBXN6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN6 Gene

Disorders for UBXN6 Gene

Relevant External Links for UBXN6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBXN6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBXN6 Gene

Publications for UBXN6 Gene

  1. Identification and characterization of UBXD1, a novel UBX domain- containing gene on human chromosome 19p13, and its mouse ortholog. (PMID: 11342112) Carim-Todd L. … Sumoy L. (Biochim. Biophys. Acta 2001) 2 3 4 64
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4 64
  3. The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors. (PMID: 21896481) Stapf C. … Buchberger A. (J. Biol. Chem. 2011) 3 4 64
  4. Ubxd1 is a novel co-factor of the human p97 ATPase. (PMID: 18656546) Madsen L. … Hartmann-Petersen R. (Int. J. Biochem. Cell Biol. 2008) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for UBXN6 Gene

  • Addgene plasmids for UBXN6

Sources for UBXN6 Gene

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