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Aliases for UBXN4 Gene

Aliases for UBXN4 Gene

  • UBX Domain Protein 4 2 3 5
  • Erasin 2 3 4
  • UBX Domain-Containing Protein 2 3 4
  • UBX Domain Containing 2 2 3
  • UBXDC1 3 4
  • UBXD2 3 4
  • UBX Domain-Containing 2 2
  • UBX Domain-Containing 1 3
  • KIAA0242 4

External Ids for UBXN4 Gene

Previous HGNC Symbols for UBXN4 Gene

  • UBXDC1
  • UBXD2

Previous GeneCards Identifiers for UBXN4 Gene

  • GC02P136216
  • GC02P136500
  • GC02P128493

Summaries for UBXN4 Gene

Entrez Gene Summary for UBXN4 Gene

  • UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UBXN4 Gene

UBXN4 (UBX Domain Protein 4) is a Protein Coding gene. An important paralog of this gene is UBXN1.

UniProtKB/Swiss-Prot for UBXN4 Gene

  • Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).

Gene Wiki entry for UBXN4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN4 Gene

Genomics for UBXN4 Gene

Regulatory Elements for UBXN4 Gene

Enhancers for UBXN4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBXN4 on UCSC Golden Path with GeneCards custom track

Promoters for UBXN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBXN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBXN4 Gene

135,741,619 bp from pter
135,785,063 bp from pter
43,445 bases
Plus strand

Genomic View for UBXN4 Gene

Genes around UBXN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN4 Gene

Proteins for UBXN4 Gene

  • Protein details for UBXN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UBX domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • A8K9W4
    • Q4ZG56
    • Q8IYM5

    Protein attributes for UBXN4 Gene

    508 amino acids
    Molecular mass:
    56778 Da
    Quaternary structure:
    • Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.
    • Sequence=BAA13437.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBXN4 Gene

neXtProt entry for UBXN4 Gene

Proteomics data for UBXN4 Gene at MOPED

Post-translational modifications for UBXN4 Gene

  • Ubiquitination at Lys 285, Lys 301, and Lys 459
  • Modification sites at PhosphoSitePlus

Other Protein References for UBXN4 Gene

No data available for DME Specific Peptides for UBXN4 Gene

Domains & Families for UBXN4 Gene

Gene Families for UBXN4 Gene

Protein Domains for UBXN4 Gene

Suggested Antigen Peptide Sequences for UBXN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The UBX domain is required for interaction with VCP.
  • The UBX domain is required for interaction with VCP.
  • The intramembrane domain also contains the signal for ER targeting.
  • Contains 1 UBX domain.
genes like me logo Genes that share domains with UBXN4: view

Function for UBXN4 Gene

Molecular function for UBXN4 Gene

UniProtKB/Swiss-Prot Function:
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).
UniProtKB/Swiss-Prot Induction:
By ER stress-inducing agents such as tunicamycin, thapsigargin, DTT and the calcium ionophore A23187 (at protein level).
genes like me logo Genes that share phenotypes with UBXN4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBXN4 Gene

Localization for UBXN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN4 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus envelope. Note=Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER.

Subcellular locations from

Jensen Localization Image for UBXN4 Gene COMPARTMENTS Subcellular localization image for UBXN4 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
cytosol 3
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UBXN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with UBXN4: view

Pathways & Interactions for UBXN4 Gene

SuperPathways for UBXN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein IEA --
genes like me logo Genes that share ontologies with UBXN4: view

No data available for Pathways by source and SIGNOR curated interactions for UBXN4 Gene

Drugs & Compounds for UBXN4 Gene

(1) Drugs for UBXN4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with UBXN4: view

Transcripts for UBXN4 Gene

Unigene Clusters for UBXN4 Gene

UBX domain protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN4 Gene

No ASD Table

Relevant External Links for UBXN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBXN4 Gene

mRNA expression in normal human tissues for UBXN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBXN4 Gene

This gene is overexpressed in Nasal epithelium (17.2) and Breast (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBXN4 Gene

SOURCE GeneReport for Unigene cluster for UBXN4 Gene Hs.591242

mRNA Expression by UniProt/SwissProt for UBXN4 Gene

Tissue specificity: Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).
genes like me logo Genes that share expression patterns with UBXN4: view

Protein tissue co-expression partners for UBXN4 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for UBXN4 Gene

Orthologs for UBXN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBXN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UBXN4 35
  • 90.62 (n)
  • 91.93 (a)
UBXN4 36
  • 91 (a)
(Canis familiaris)
Mammalia UBXN4 35
  • 90.6 (n)
  • 91.72 (a)
UBXN4 36
  • 91 (a)
(Mus musculus)
Mammalia Ubxn4 35
  • 85.05 (n)
  • 88.14 (a)
Ubxn4 16
Ubxn4 36
  • 90 (a)
(Pan troglodytes)
Mammalia UBXN4 35
  • 99.8 (n)
  • 100 (a)
UBXN4 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Ubxn4 35
  • 84.91 (n)
  • 88.34 (a)
(Monodelphis domestica)
Mammalia UBXN4 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia UBXN4 36
  • 65 (a)
(Gallus gallus)
Aves UBXN4 35
  • 72.4 (n)
  • 71.94 (a)
UBXN4 36
  • 70 (a)
(Anolis carolinensis)
Reptilia UBXN4 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.687 35
ubxn4 35
  • 65.35 (n)
  • 66.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15108 35
(Danio rerio)
Actinopterygii Dr.16757 35
ubxn4 35
  • 59.78 (n)
  • 60.33 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2477 35
fruit fly
(Drosophila melanogaster)
Insecta CG8042 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea ubxn-4 35
  • 42.67 (n)
  • 28.23 (a)
ubxn-4 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8299 36
  • 30 (a)
Species with no ortholog for UBXN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBXN4 Gene

Gene Tree for UBXN4 (if available)
Gene Tree for UBXN4 (if available)

Paralogs for UBXN4 Gene

Paralogs for UBXN4 Gene Pseudogenes for UBXN4 Gene

genes like me logo Genes that share paralogs with UBXN4: view

Variants for UBXN4 Gene

Sequence variations from dbSNP and Humsavar for UBXN4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2304602 - 135,780,371(+) TCTAG(C/G)AAATC reference, missense
rs1865452 -- 135,781,760(+) GAGAG(C/T)TCGTT intron-variant
rs1865453 -- 135,781,843(+) TGAGG(C/T)GCAAG intron-variant
rs1050115 -- 135,754,247(+) GATGA(A/G)CTTGT reference, synonymous-codon
rs2019170 -- 135,771,430(+) gacat(C/G)gtgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBXN4 Gene

Variant ID Type Subtype PubMed ID
esv34026 CNV Loss 18971310
nsv819183 CNV Loss 19587683
nsv821734 CNV Loss 20364138

Variation tolerance for UBXN4 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UBXN4 Gene

Disorders for UBXN4 Gene

Relevant External Links for UBXN4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBXN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBXN4 Gene

Publications for UBXN4 Gene

  1. Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. (PMID: 16968747) Liang J. … Monteiro M.J. (J. Cell Sci. 2006) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for UBXN4 Gene

Sources for UBXN4 Gene