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Aliases for UBXN4 Gene

Aliases for UBXN4 Gene

  • UBX Domain Protein 4 2 3
  • Erasin 2 3 4 6
  • UBXD2 3 4 6
  • UBX Domain-Containing Protein 2 3 4
  • UBX Domain Containing 2 2 3
  • UBXDC1 3 4
  • UBX Domain-Containing Protein 4 3
  • UBX Domain-Containing 1 3
  • UBX Domain-Containing 2 2
  • KIAA2042 6
  • KIAA0242 4

External Ids for UBXN4 Gene

Previous HGNC Symbols for UBXN4 Gene

  • UBXDC1
  • UBXD2

Previous GeneCards Identifiers for UBXN4 Gene

  • GC02P136216
  • GC02P136500
  • GC02P128493

Summaries for UBXN4 Gene

Entrez Gene Summary for UBXN4 Gene

  • UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UBXN4 Gene

UBXN4 (UBX Domain Protein 4) is a Protein Coding gene. An important paralog of this gene is UBXN1.

UniProtKB/Swiss-Prot for UBXN4 Gene

  • Involved in endoplasmic reticulum-associated protein degradation (ERAD).

Gene Wiki entry for UBXN4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN4 Gene

Genomics for UBXN4 Gene

Regulatory Elements for UBXN4 Gene

Genomic Location for UBXN4 Gene

135,741,619 bp from pter
135,785,063 bp from pter
43,445 bases
Plus strand

Genomic View for UBXN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBXN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN4 Gene

Proteins for UBXN4 Gene

  • Protein details for UBXN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UBX domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • A8K9W4
    • Q4ZG56
    • Q8IYM5

    Protein attributes for UBXN4 Gene

    508 amino acids
    Molecular mass:
    56778 Da
    Quaternary structure:
    • Directly interacts with VCP.
    • Sequence=BAA13437.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBXN4 Gene

neXtProt entry for UBXN4 Gene

Proteomics data for UBXN4 Gene at MOPED

Post-translational modifications for UBXN4 Gene

  • Ubiquitination at Lys285, Lys301, and Lys459
  • Modification sites at PhosphoSitePlus

Other Protein References for UBXN4 Gene

Antibody Products

No data available for DME Specific Peptides for UBXN4 Gene

Domains for UBXN4 Gene

Gene Families for UBXN4 Gene

Protein Domains for UBXN4 Gene

Suggested Antigen Peptide Sequences for UBXN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The UBX domain is required for interaction with VCP
  • The UBX domain is required for interaction with VCP
  • The intramembrane domain also contains the signal for ER targeting
  • Contains 1 UBX domain.
genes like me logo Genes that share domains with UBXN4: view

Function for UBXN4 Gene

Molecular function for UBXN4 Gene

UniProtKB/Swiss-Prot Function:
Involved in endoplasmic reticulum-associated protein degradation (ERAD).
UniProtKB/Swiss-Prot Induction:
By ER stress-inducing agents such as tunicamycin, thapsigargin, DTT and the calcium ionophore A23187 (at protein level)

Gene Ontology (GO) - Molecular Function for UBXN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18775313
genes like me logo Genes that share ontologies with UBXN4: view

Phenotypes for UBXN4 Gene

GenomeRNAi human phenotypes for UBXN4:
genes like me logo Genes that share phenotypes with UBXN4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBXN4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UBXN4 Gene

Localization for UBXN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN4 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus envelope. Note=Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER.

Subcellular locations from

Jensen Localization Image for UBXN4 Gene COMPARTMENTS Subcellular localization image for UBXN4 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UBXN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope IEA --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with UBXN4: view

Pathways for UBXN4 Gene

SuperPathways for UBXN4 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for UBXN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein IEA --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 19822669
genes like me logo Genes that share ontologies with UBXN4: view

No data available for Pathways by source for UBXN4 Gene

Drugs for UBXN4 Gene

(1) HMDB Compounds for UBXN4 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with UBXN4: view

Transcripts for UBXN4 Gene

Unigene Clusters for UBXN4 Gene

UBX domain protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBXN4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN4 Gene

No ASD Table

Relevant External Links for UBXN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBXN4 Gene

mRNA expression in normal human tissues for UBXN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for UBXN4 Gene

This gene is overexpressed in Nasal epithelium (17.2) and Breast (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBXN4 Gene

SOURCE GeneReport for Unigene cluster for UBXN4 Gene Hs.591242

mRNA Expression by UniProt/SwissProt for UBXN4 Gene

Tissue specificity: Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).
genes like me logo Genes that share expressions with UBXN4: view

Expression partners for UBXN4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UBXN4 Gene

Orthologs for UBXN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBXN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UBXN4 35
  • 90.62 (n)
  • 91.93 (a)
UBXN4 36
  • 91 (a)
(Canis familiaris)
Mammalia UBXN4 35
  • 90.6 (n)
  • 91.72 (a)
UBXN4 36
  • 91 (a)
(Mus musculus)
Mammalia Ubxn4 35
  • 85.05 (n)
  • 88.14 (a)
Ubxn4 16
Ubxn4 36
  • 90 (a)
(Pan troglodytes)
Mammalia UBXN4 35
  • 99.8 (n)
  • 100 (a)
UBXN4 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Ubxn4 35
  • 84.91 (n)
  • 88.34 (a)
(Monodelphis domestica)
Mammalia UBXN4 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia UBXN4 36
  • 65 (a)
(Gallus gallus)
Aves UBXN4 35
  • 72.4 (n)
  • 71.94 (a)
UBXN4 36
  • 70 (a)
(Anolis carolinensis)
Reptilia UBXN4 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.687 35
ubxn4 35
  • 65.35 (n)
  • 66.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15108 35
(Danio rerio)
Actinopterygii Dr.16757 35
ubxn4 35
  • 59.78 (n)
  • 60.33 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2477 35
fruit fly
(Drosophila melanogaster)
Insecta CG8042 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea ubxn-4 35
  • 42.67 (n)
  • 28.23 (a)
ubxn-4 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8299 36
  • 30 (a)
Species with no ortholog for UBXN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBXN4 Gene

Gene Tree for UBXN4 (if available)
Gene Tree for UBXN4 (if available)

Paralogs for UBXN4 Gene

Paralogs for UBXN4 Gene Pseudogenes for UBXN4 Gene

genes like me logo Genes that share paralogs with UBXN4: view

Variants for UBXN4 Gene

Sequence variations from dbSNP and Humsavar for UBXN4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1050115 -- 135,754,247(+) GATGA(A/G)CTTGT reference, synonymous-codon
rs1438304 -- 135,745,587(-) TTCAC(C/T)ATTTT intron-variant
rs1438305 -- 135,745,222(-) GAAGA(C/G)ACTGA intron-variant
rs1438306 -- 135,741,618(-) AGGAA(A/G)GCGGT upstream-variant-2KB
rs1438307 -- 135,741,596(-) CTAAC(A/C)GCTAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UBXN4 Gene

Variant ID Type Subtype PubMed ID
esv34026 CNV Loss 18971310
nsv819183 CNV Loss 19587683
nsv821734 CNV Loss 20364138

Relevant External Links for UBXN4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN4 Gene

Disorders for UBXN4 Gene

Relevant External Links for UBXN4

Genetic Association Database (GAD)

No disorders were found for UBXN4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for UBXN4 Gene

Publications for UBXN4 Gene

  1. Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. (PMID: 16968747) Liang J. … Monteiro M.J. (J. Cell Sci. 2006) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries. (PMID: 21979947) Li X. … Rabinowitz Y.S. (Hum. Mol. Genet. 2012) 3 48
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for UBXN4 Gene

Sources for UBXN4 Gene

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