Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UBXN4 Gene

protein-coding   GIFtS: 52
GCID: GC02P136500

UBX Domain Protein 4

(Previous names: UBX domain-containing 2, UBX domain containing 2)
(Previous symbols: UBXDC1, UBXD2)
  Search for UBXN4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
UBX Domain Protein 41 2     UBX Domain-Containing 12
UBXD21 2 3 5     UBX Domain-Containing Protein 42
UBXDC11 2 3     Erasin3
UBX Domain Containing 21 2     KIAA02423
erasin1 2     ERASIN5
UBX Domain-Containing Protein 22 3     KIAA20425
UBX Domain-Containing 21     

External Ids:    HGNC: 148601   Entrez Gene: 231902   Ensembl: ENSG000001442247   OMIM: 6112165   UniProtKB: Q925753   

Export aliases for UBXN4 gene to outside databases

Previous GC identifers: GC02P136216 GC02P128493


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UBXN4 Gene:
UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein
(VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 (PubMed
16968747)).(supplied by OMIM, Mar 2008)

GeneCards Summary for UBXN4 Gene:
UBXN4 (UBX domain protein 4) is a protein-coding gene. An important paralog of this gene is UBXN1.

UniProtKB/Swiss-Prot: UBXN4_HUMAN, Q92575
Function: Involved in endoplasmic reticulum-associated protein degradation (ERAD)

Gene Wiki entry for UBXN4 (UBXD2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBXN4 gene promoter:
         TBP   AREB6   USF1   AML1a   USF-1   MyoD   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBXN4 promoter sequence
   Search Chromatin IP Primers for UBXN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBXN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.3   Ensembl cytogenetic band:  2q21.3   HGNC cytogenetic band: 2q21.3-q22.1

UBXN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBXN4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P136500:  view genomic region     (about GC identifiers)

Start:
136,499,189 bp from pter      End:
136,542,633 bp from pter
Size:
43,445 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UBXN4_HUMAN, Q92575 (See protein sequence)
Recommended Name: UBX domain-containing protein 4  
Size: 508 amino acids; 56778 Da
Subunit: Directly interacts with VCP
Sequence caution: Sequence=BAA13437.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for UBXN4:
2KXJ (3D)    
Secondary accessions: A8K9W4 Q4ZG56 Q8IYM5

Explore the universe of human proteins at neXtProt for UBXN4: NX_Q92575

Explore proteomics data for UBXN4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys285, Lys301, Lys459
  • Modification sites at PhosphoSitePlus

  • See UBXN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055422.1  
    ENSEMBL proteins: 
     ENSP00000272638   ENSP00000401748   ENSP00000410516   ENSP00000391586  

    UBXN4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UBXN4
    OriGene Protein Over-expression Lysate for UBXN4
    OriGene MassSpec for UBXN4
    OriGene Custom Protein Services for UBXN4
    GenScript Custom Purified and Recombinant Proteins Services for UBXN4
    Novus Biologicals UBXN4 Protein
    Novus Biologicals UBXN4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBXN4

     
    Search eBioscience for Proteins for UBXN4 

    UBXN4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UBXN4
    Novus Biologicals UBXN4 Antibodies
    Search for Antibodies for UBXN4 at Abcam
    Cloud-Clone Corp. Antibodies for UBXN4
    Search ThermoFisher Antibodies for UBXN4
    LSBio Antibodies in human, mouse, rat for UBXN4

    UBXN4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBXN4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBXN4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UBXN4
    Cloud-Clone Corp. CLIAs for UBXN4
    Search eBioscience for ELISAs for UBXN4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    UBXN: UBX domain containing

    2 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR001012 UBX

    Graphical View of Domain Structure for InterPro Entry Q92575

    ProtoNet protein and cluster: Q92575

    UniProtKB/Swiss-Prot: UBXN4_HUMAN, Q92575
    Domain: The UBX domain is required for interaction with VCP
    Domain: The intramembrane domain also contains the signal for ER targeting
    Similarity: Contains 1 UBX domain


    Find genes that share domains with UBXN4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBXN4_HUMAN, Q92575
    Function: Involved in endoplasmic reticulum-associated protein degradation (ERAD)
    Induction: By ER stress-inducing agents such as tunicamycin, thapsigargin, DTT and the calcium ionophore A23187
    (at protein level)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18775313
         
    Find genes that share ontologies with UBXN4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UBXN4:
     High actin ratio cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBXN4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBXN4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBXN4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBXN4

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat UBXN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBXN4 (see all 49):
    hsa-let-7d hsa-miR-25 hsa-miR-374a hsa-miR-766 hsa-let-7g hsa-miR-183* hsa-let-7a hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidUBXN4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UBXN4
    Predesigned siRNA for gene silencing in human, mouse, rat UBXN4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBXN4

    Clone
    Products:
         
    OriGene clones in human, mouse for UBXN4 (see all 8)
    OriGene ORF clones in mouse, rat for UBXN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBXN4 (NM_014607)
    Sino Biological Human cDNA Clone for UBXN4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBXN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UBXN4
    Browse ESI BIO Cell Lines and PureStem Progenitors for UBXN4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UBXN4_HUMAN, Q92575: Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus envelope. Note=Both the
    N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    cytosol3
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005635nuclear envelope IEA--
    GO:0005737cytoplasm IDA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--

    Find genes that share ontologies with UBXN4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBXN4: 
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UBXN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for UBXN4 (Q925751, 2, 3 ENSP000002726384) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCPP550721, 3, ENSP000003517774EBI-723441,EBI-355164 I2D: score=2 STRING: ENSP00000351777
    TOM1L1O756742, 3MINT-64319 I2D: score=5 
    ZNF24P170283I2D: score=1 
    UBQLN1ENSP000003655764STRING: ENSP00000365576
    SEL1LENSP000003370534STRING: ENSP00000337053
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006986response to unfolded protein IEA--

    Find genes that share ontologies with UBXN4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBXN4

    1 HMDB Compound for UBXN4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UBXN4 gene: 
    NM_014607.3  

    Unigene Cluster for UBXN4:

    UBX domain protein 4
    Hs.591242  [show with all ESTs]
    Unigene Representative Sequence: NM_014607
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272638(uc002tur.3 uc002tus.3) ENST00000415164 ENST00000426921
    ENST00000416538 ENST00000467065 ENST00000470687 ENST00000490163(uc002tut.3)
    ENST00000471246
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UBXN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBXN4 (see all 49):
    hsa-let-7d hsa-miR-25 hsa-miR-374a hsa-miR-766 hsa-let-7g hsa-miR-183* hsa-let-7a hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidUBXN4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UBXN4
    Predesigned siRNA for gene silencing in human, mouse, rat UBXN4
    Clone
    Products:
         
    OriGene clones in human, mouse for UBXN4 (see all 8)
    OriGene ORF clones in mouse, rat for UBXN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBXN4 (NM_014607)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBXN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UBXN4
    OriGene qSTAR qPCR primer pairs in human, mouse for UBXN4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBXN4
      QuantiTect SYBR Green Assays in human, mouse, rat UBXN4
      QuantiFast Probe-based Assays in human, mouse, rat UBXN4

    Additional mRNA sequence: 

    AK026971.1 AK056055.1 AK095402.1 AK292829.1 AK304096.1 BC035594.2 BX647662.1 D87684.1 
    EF199840.1 

    18 DOTS entries:

    DT.95154663  DT.95131553  DT.119331  DT.91756873  DT.101983743  DT.120981999  DT.95072025  DT.95154664 
    DT.120981941  DT.100804686  DT.40116485  DT.95154662  DT.100804687  DT.102830973  DT.91756888  DT.120981916 
    DT.120981929  DT.120981975 

    Selected AceView cDNA sequences (see all 461):

    CR600206 CA395992 F34597 CA941478 AI375533 AU131019 AA454655 CD369550 
    BP376965 AW002458 BG565429 AA554470 AI521595 AW235702 BM141896 BM712723 
    C02511 BU784314 AA298976 N29889 AA298838 D62938 AA622115 CB147643 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UBXN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCCAGGA
    UBXN4 Expression
    About this image


    UBXN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
     
     Lung (Respiratory System)
    UBXN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBXN4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591242

    UniProtKB/Swiss-Prot: UBXN4_HUMAN, Q92575
    Tissue specificity: Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle,
    kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBXN4: 
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UBXN4
    OriGene qSTAR qPCR primer pairs in human, mouse for UBXN4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBXN4
    QuantiTect SYBR Green Assays in human, mouse, rat UBXN4
    QuantiFast Probe-based Assays in human, mouse, rat UBXN4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for UBXN4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubxn41 , 5 UBX domain protein 41, 5 85.05(n)1
    88.14(a)1
      1 (55.80 cM)5
    678121  NM_026390.21  NP_080666.21 
     1282441815 
    chicken
    (Gallus gallus)
    Aves UBXN41 UBX domain protein 4 72.4(n)
    71.94(a)
      424293  XM_422138.4  XP_422138.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBXN46
    UBX domain protein 4
    69(a)
    1 ↔ 1
    1(96693704-96715114)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.151082 Xenopus laevis transcribed sequence with weak similarity more 75.25(n)    BX844490.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.167572 Danio rerio cDNA clone MGC73362 IMAGE4144799, complete more 74.33(n)    BC064707.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80426
    --
    23(a)
    1 ↔ 1
    3L(7965549-7968091)
    worm
    (Caenorhabditis elegans)
    Secernentea ubxn-41 ubxn-4 42.67(n)
    28.23(a)
      176187  NM_066455.4  NP_498856.1 


    ENSEMBL Gene Tree for UBXN4 (if available)
    TreeFam Gene Tree for UBXN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UBXN4 gene
    UBXN12  
    Selected SIMAP similar genes for UBXN4 using alignment to 4 protein entries:     UBXN4_HUMAN (see all proteins) (see all similar genes):
    TNNT1    CLTA    AAMDC    LSM12    ADCK1    COQ5
    NDC80    TM2D1    SEC14L3    RBP7    RPS13    TUBA1C
    FLJ00047    TMX3    ZNF114    PFKFB3    ZNF429    MRPL45

    Find genes that share paralogs with UBXN4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for UBXN4
    PGOHUM00000241271


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UBXN4 (see all 886)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124761161,2
    C,F,H--136497199(+) tattcA/Gattgc 1 -- us2k14Minor allele frequency- G:0.15WA NA EA 360
    rs1819707461,2
    --136497276(+) TCTTGC/TTCTTT 1 -- us2k10--------
    rs2005683511,2
    C--136497280(+) GCTCTC/TTCGCC 1 -- us2k10--------
    rs1863962791,2
    --136497327(+) CAACCA/TCCACC 1 -- us2k10--------
    rs621688481,2
    F--136497347(+) CAAGCG/AATTCT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1909012541,2
    --136497791(+) TCCCCA/GACACG 1 -- us2k10--------
    rs1513005171,2
    --136497841(+) ATGTTC/TGGTCC 1 -- us2k10--------
    rs1808900981,2
    --136498140(+) TCAAAC/TTTCCA 1 -- us2k10--------
    rs1405884571,2
    --136498156(+) CCATTA/CAAGTT 1 -- us2k10--------
    rs771012741,2
    F--136498211(+) ATAGAA/CGCAAC 1 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for UBXN4 (136499189 - 136542633 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UBXN4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821734CNV Loss20364138
    nsv819183CNV Loss19587683
    esv34026CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBXN4
    DNA2.0 Custom Variant and Variant Library Synthesis for UBXN4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611216    OMIM disorders: --


    Find genes that share disorders with UBXN4           About GenesLikeMe

    Genetic Association Database (GAD): UBXN4

    Export disorders for UBXN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UBXN4 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with UBXN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. (PubMed id 16968747)1, 2, 3 Liang J....Monteiro M.J. (J. Cell Sci. 2006)
    2. A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries. (PubMed id 21979947)1, 4 Li X....Rabinowitz Y.S. (Hum. Mol. Genet. 2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. (PubMed id 19822669)1 Lim P.J....Monteiro M.J. (J. Cell Biol. 2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23190 HGNC: 14860 AceView: UBXD2 Ensembl:ENSG00000144224 euGenes: HUgn23190
    ECgene: UBXN4 H-InvDB: UBXN4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0242 KIAA2042

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UBXN4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UBXN4 gene:
    Search GeneIP for patents involving UBXN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for UBXN4  
     OriGene qPCR primer pairs and template standards for UBXN4   OriGene Protein Over-expression Lysate for UBXN4  
     OriGene MassSpec something-or-other for UBXN4   OriGene clones in human, mouse for UBXN4  
     OriGene qSTAR qPCR primer pairs in human, mouse for UBXN4   OriGene Purified Protein for UBXN4  
     OriGene ORF clones in mouse, rat for UBXN4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UBXN4   OriGene Custom Protein Services for UBXN4  

     
     
     Block miRNA regulation of human, mouse, rat UBXN4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UBXN4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBXN4 Predesigned siRNA for gene silencing in human, mouse, rat UBXN4
     QuantiFast Probe-based Assays in human, mouse, rat UBXN4 QuantiTect SYBR Green Assays in human, mouse, rat UBXN4
     PCR Arrays including human, mouse, rat UBXN4 Search Chromatin IP Primers for UBXN4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBXN4  Search GeneGlobe Interaction Network for UBXN4
     Regulatory tfbs in UBXN4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UBXN4 GenScript cDNA clones with any tag delivered in your preferred vector for UBXN4
     GenScript Custom Assay Services for UBXN4 GenScript Custom overexpressing Cell Line Services for UBXN4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UBXN4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for UBXN4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UBXN4 antibodies
     UBXN4 proteins
     UBXN4 lysates
     Search for Antibodies for UBXN4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for UBXN4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for UBXN4
     Antibodies for UBXN4
     ELISAs for UBXN4
     CLIAs for UBXN4



     Browse ESI BIO Cell Lines and PureStem Progenitors for UBXN4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN4
     SwitchGear 3'UTR luciferase reporter plasmids for UBXN4
     SwitchGear Promoter luciferase reporter plasmids for UBXN4
     Search ThermoFisher Antibodies for UBXN4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBXN4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBXN4
     LSBio Antibodies in human, mouse, rat for UBXN4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for UBXN4
      Search eBioscience for proteins for UBXN4
      Search eBioscience for elisas for UBXN4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UBXN4 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4