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Aliases for UBXN2B Gene

Aliases for UBXN2B Gene

  • UBX Domain Protein 2B 2 3
  • NSFL1 Cofactor P37 3 4
  • P97 Cofactor P37 3 4
  • P37 3 6
  • UBX Domain-Containing Protein 2B 3
  • LOC137886 6

External Ids for UBXN2B Gene

Previous GeneCards Identifiers for UBXN2B Gene

  • GC08P059487
  • GC08P059323
  • GC08P054812

Summaries for UBXN2B Gene

GeneCards Summary for UBXN2B Gene

UBXN2B (UBX Domain Protein 2B) is a Protein Coding gene. An important paralog of this gene is NSFL1C.

UniProtKB/Swiss-Prot for UBXN2B Gene

  • Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN2B Gene

Genomics for UBXN2B Gene

Regulatory Elements for UBXN2B Gene

Genomic Location for UBXN2B Gene

Start:
58,411,264 bp from pter
End:
58,451,501 bp from pter
Size:
40,238 bases
Orientation:
Plus strand

Genomic View for UBXN2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBXN2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN2B Gene

Proteins for UBXN2B Gene

  • Protein details for UBXN2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CS0-UBX2B_HUMAN
    Recommended name:
    UBX domain-containing protein 2B
    Protein Accession:
    Q14CS0
    Secondary Accessions:
    • B3KWZ3

    Protein attributes for UBXN2B Gene

    Size:
    331 amino acids
    Molecular mass:
    37077 Da
    Quaternary structure:
    • Interacts with VCP. Does not bind ubiquitin (By similarity).

neXtProt entry for UBXN2B Gene

Proteomics data for UBXN2B Gene at MOPED

Post-translational modifications for UBXN2B Gene

  • Ubiquitination at Lys207
  • Modification sites at PhosphoSitePlus

Other Protein References for UBXN2B Gene

No data available for DME Specific Peptides for UBXN2B Gene

Domains for UBXN2B Gene

Gene Families for UBXN2B Gene

HGNC:
  • UBXN :UBX domain containing

Protein Domains for UBXN2B Gene

Suggested Antigen Peptide Sequences for UBXN2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14CS0

UniProtKB/Swiss-Prot:

UBX2B_HUMAN :
  • Q14CS0
Domain:
  • Contains 1 SEP domain.
  • Contains 1 UBX domain.
Family:
  • Belongs to the NSFL1C family.
genes like me logo Genes that share domains with UBXN2B: view

Function for UBXN2B Gene

Molecular function for UBXN2B Gene

UniProtKB/Swiss-Prot Function: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.

Gene Ontology (GO) - Molecular Function for UBXN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008599 protein phosphatase type 1 regulator activity IBA --
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with UBXN2B: view

Animal Model Products

CRISPR Products

miRNA for UBXN2B Gene

miRTarBase miRNAs that target UBXN2B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBXN2B Gene

Localization for UBXN2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN2B Gene

Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBXN2B Gene COMPARTMENTS Subcellular localization image for UBXN2B gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for UBXN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with UBXN2B: view

Pathways for UBXN2B Gene

SuperPathways for UBXN2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IBA --
GO:0007030 Golgi organization IBA --
GO:0031468 nuclear envelope reassembly IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0050790 regulation of catalytic activity IBA --
genes like me logo Genes that share ontologies with UBXN2B: view

No data available for Pathways by source for UBXN2B Gene

Transcripts for UBXN2B Gene

Unigene Clusters for UBXN2B Gene

UBX domain protein 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBXN2B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for UBXN2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN2B Gene

No ASD Table

Relevant External Links for UBXN2B Gene

GeneLoc Exon Structure for
UBXN2B
ECgene alternative splicing isoforms for
UBXN2B

Expression for UBXN2B Gene

mRNA expression in normal human tissues for UBXN2B Gene

mRNA differential expression in normal tissues according to GTEx for UBXN2B Gene

This gene is overexpressed in Whole Blood (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBXN2B Gene

SOURCE GeneReport for Unigene cluster for UBXN2B Gene Hs.155572

genes like me logo Genes that share expressions with UBXN2B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for UBXN2B Gene

Orthologs for UBXN2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBXN2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBXN2B 35
  • 99.7 (n)
  • 100 (a)
UBXN2B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBXN2B 35
  • 89.7 (n)
  • 91.17 (a)
UBXN2B 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBXN2B 35
  • 93.43 (n)
  • 95.76 (a)
UBXN2B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubxn2b 35
  • 85.8 (n)
  • 85.5 (a)
Ubxn2b 16
Ubxn2b 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBXN2B 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBXN2B 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubxn2b 35
  • 86.91 (n)
  • 88.82 (a)
chicken
(Gallus gallus)
Aves UBXN2B 35
  • 77.2 (n)
  • 79.03 (a)
UBXN2B 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBXN2B 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32474 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn2b 35
  • 67.88 (n)
  • 68.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42383 36
  • 24 (a)
ManyToMany
p47 36
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ubxn-2 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SHP1 36
  • 19 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os06g0634600 35
  • 47.14 (n)
  • 38.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2402 36
  • 34 (a)
OneToMany
Species with no ortholog for UBXN2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UBXN2B Gene

ENSEMBL:
Gene Tree for UBXN2B (if available)
TreeFam:
Gene Tree for UBXN2B (if available)

Paralogs for UBXN2B Gene

Paralogs for UBXN2B Gene

Selected SIMAP similar genes for UBXN2B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for UBXN2B Gene

genes like me logo Genes that share paralogs with UBXN2B: view

Variants for UBXN2B Gene

Sequence variations from dbSNP and Humsavar for UBXN2B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs7958 -- 58,451,294(+) ATTTC(A/G)TGTGT utr-variant-3-prime
rs11752 -- 58,451,079(+) TGAAC(A/G/T)TTGTA utr-variant-3-prime
rs726012 -- 58,429,796(-) TTCCA(A/G)GGTAA intron-variant
rs1001706 -- 58,427,355(+) ctgct(C/T)gggag intron-variant
rs1052499 -- 58,434,927(+) ATTAC(A/T)GCTGG intron-variant, utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for UBXN2B Gene

Variant ID Type Subtype PubMed ID
essv723 CNV CNV 17122850
nsv890938 CNV Gain 21882294

Relevant External Links for UBXN2B Gene

HapMap Linkage Disequilibrium report
UBXN2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN2B Gene

Disorders for UBXN2B Gene

Relevant External Links for UBXN2B

Genetic Association Database (GAD)
UBXN2B
Human Genome Epidemiology (HuGE) Navigator
UBXN2B
genes like me logo Genes that share disorders with UBXN2B: view

No data available for UniProtKB/Swiss-Prot for UBXN2B Gene

Publications for UBXN2B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis. (PMID: 17141156) Uchiyama K. … Kondo H. (Dev. Cell 2006) 3 4
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3

Products for UBXN2B Gene

Sources for UBXN2B Gene

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