UBXN2B Gene
protein-coding GIFtS: 44
GCID: GC08P059323
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UBX domain protein 2B
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Aliases
for UBXN2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| UBX Domain Protein 2B1 2 | | P371 | | NSFL1 Cofactor P372 3 | | P97 Cofactor P372 3 | | UBX Domain-Containing Protein 2B2 | | LOC1378865 |
Export aliases for UBXN2B gene to outside databasesPrevious GC identifers: GC08P059487 GC08P054812 |
Summaries
for UBXN2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBX2B_HUMAN, Q14CS0Function: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmicreticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP hasmembrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required,but not its deubiquitinating activity
|
Genomic Views
for UBXN2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBXN2B gene promoter:
AhR Spz1 Elk-1 FOXD3 c-Ets-1 MZF-1 HFH-1 Pax-4a Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBXN2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBXN2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q12.1 Ensembl cytogenetic band: 8q12.1 HGNC cytogenetic band: 8q12.1UBXN2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P059323: view genomic region
(about GC identifiers)
Start:
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59,323,823 bp from pter |
End:
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59,364,060 bp from pter |
Size:
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40,238 bases |
Orientation:
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plus strand |
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Proteins
for UBXN2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBX2B_HUMAN, Q14CS0 (See
protein sequence)Recommended Name: UBX domain-containing protein 2B Size: 331 amino acids; 37077 Da
Subunit: Interacts with VCP. Does not bind ubiquitin (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm, cytosol (By similarity). Endoplasmic reticulum (Bysimilarity). Golgi apparatus (By similarity)
Secondary accessions: B3KWZ3Explore the universe of human proteins at neXtProt for UBXN2B: NX_Q14CS0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14CS0
UBXN2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001071087.1
ENSEMBL proteins: ENSP00000382507 ENSP00000427759 ENSP00000428314 ENSP00000428241
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
UBXN2B for ontologies About GeneDecksing
UBXN2B Antibody Products:
Assay Products for UBXN2B: |
Protein
Domains /
Families
for UBXN2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBXN2B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14CS0ProtoNet protein and cluster: Q14CS0 2 Blocks protein families: IPB001012 UBX domain IPB012989 SEP
UniProtKB/Swiss-Prot: UBX2B_HUMAN, Q14CS0Similarity: Belongs to the NSFL1C familySimilarity: Contains 1 SEP domainSimilarity: Contains 1 UBX domain |
Function
for UBXN2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBX2B_HUMAN, Q14CS0Function: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmicreticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP hasmembrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required,but not its deubiquitinating activity
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN2B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN2B |
|
Pathways & Interactions
for UBXN2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBXN2B
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for UBXN2B (Q14CS03 ENSP000003825074) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for UBXN2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBXN2B
Search CenterWatch for drugs/clinical trials and news about UBXN2B / UBX2B
|
Transcripts
for UBXN2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBXN2B gene: NM_001077619.1 Unigene Cluster for UBXN2B: UBX domain protein 2B Hs.155572 [show with all ESTs]Unigene Representative Sequence: NM_0010776195 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000399598(uc003xtl.3) ENST00000522978 ENST00000520732 ENST00000523409
ENST00000521796
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN2B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBXN2B (NM_001077619) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBXN2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN2B |
Additional cDNA sequence: AK054658.1 AK091561.1 AK126300.1 AL831990.2 AL833075.2 BC070386.1 BC113645.1 BX647876.2 U79282.1 7 DOTS entries: DT.214492 DT.100813407 DT.75119746 DT.91712440 DT.40229368 DT.40258251 DT.92056703 24/131 AceView cDNA sequences (see all 131): BM557875 BU146383 AI888361 BQ027160 AK126300 BQ937602 BM464311 BF508075 AA012939 AW474697 AI090885 BU622593 CA951114 CA422938 BM781756 BM818193 BI492758 AI471953 AA894818 CA941488 AA489698 CB155575 BU616960 AA593630
GeneLoc Exon Structure
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Expression
for UBXN2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBXN2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTATGTAA
About this image
See UBXN2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBXN2B
SOURCE GeneReport for Unigene cluster: Hs.155572
SABiosciences Custom PCR Arrays for UBXN2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBXN2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBXN2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBXN2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBXN2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN2B |
Orthologs
for UBXN2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBXN2B gene from 8/25 species (see all 25) About this table
ENSEMBL Gene Tree for UBXN2B (if available)
TreeFam Gene Tree for UBXN2B (if available) |
Paralogs
for UBXN2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBXN2B gene
- UBXN2A2 NSFL1C2
2 SIMAP similar genes for UBXN2B using alignment to 4 protein entries: UBX2B_HUMAN (see all proteins):UBXN2A NSFL1C
UBXN2B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for UBXN2B
PGOHUM00000233092
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Genomic Variants
for UBXN2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBXN2B (59323823 - 59364060 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for UBXN2B
3 CNVs: 2756 82620 95456 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBXN2B |
|
Disorders
/ Diseases
for UBXN2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBXN2B for disorders About GeneDecksing
OMIM gene information: 610686
OMIM disorders: --
1  disease for UBXN2B: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: UBXN2B (1 document)
Export disorders for UBXN2B gene to outside databases
|
Publications
for UBXN2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBXN2B gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with UBXN2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis. (PubMed id 17141156)1, 2 Uchiyama K.... Kondo H. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Phosphorylation of p37 is important for Golgi disasse mbly at mitosis. (PubMed id 20875789)1 Kaneko Y....Kondo H. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
|
External Searches for UBXN2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing UBXN2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBXN2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBXN2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBXN2B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for UBXN2B gene:
Search GeneIP for patents involving UBXN2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBXN2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBXN2B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBXN2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBXN2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBXN2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBXN2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBXN2B |
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| |  |  |  |  | | | | |
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 | | | UBXN2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN2B |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN2B |
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