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UBXN2B Gene

protein-coding   GIFtS: 48
GCID: GC08P059323

UBX Domain Protein 2B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UBX Domain Protein 2B1 2
NSFL1 Cofactor P372 3
P97 Cofactor P372 3
p372 5
UBX Domain-Containing Protein 2B2
LOC1378865

External Ids:    HGNC: 270351   Entrez Gene: 1378862   Ensembl: ENSG000002151147   OMIM: 6106865   UniProtKB: Q14CS03   

Export aliases for UBXN2B gene to outside databases

Previous GC identifers: GC08P059487 GC08P054812


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UBXN2B Gene:
UBXN2B (UBX domain protein 2B) is a protein-coding gene. An important paralog of this gene is UBXN2A.

UniProtKB/Swiss-Prot: UBX2B_HUMAN, Q14CS0
Function: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and
endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex
formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L.
VCPIP1 is also required, but not its deubiquitinating activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBXN2B gene promoter:
         AhR   Spz1   Elk-1   FOXD3   c-Ets-1   MZF-1   HFH-1   Pax-4a   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for UBXN2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBXN2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12.1   Ensembl cytogenetic band:  8q12.1   HGNC cytogenetic band: 8q12.1

UBXN2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBXN2B gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P059323:  view genomic region     (about GC identifiers)

Start:
59,323,823 bp from pter      End:
59,364,060 bp from pter
Size:
40,238 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBX2B_HUMAN, Q14CS0 (See protein sequence)
Recommended Name: UBX domain-containing protein 2B  
Size: 331 amino acids; 37077 Da
Subunit: Interacts with VCP. Does not bind ubiquitin (By similarity)
Secondary accessions: B3KWZ3

Explore the universe of human proteins at neXtProt for UBXN2B: NX_Q14CS0

Explore proteomics data for UBXN2B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys207
  • Modification sites at PhosphoSitePlus

  • See UBXN2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001071087.1  
    ENSEMBL proteins: 
     ENSP00000382507   ENSP00000427759   ENSP00000428314   ENSP00000428241  

    UBXN2B Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for UBXN2B
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBXN: UBX domain containing

    2 InterPro protein domains:
     IPR012989 SEP_domain
     IPR001012 UBX

    Graphical View of Domain Structure for InterPro Entry Q14CS0

    ProtoNet protein and cluster: Q14CS0

    2 Blocks protein domains:
    IPB001012 UBX domain
    IPB012989 SEP


    UniProtKB/Swiss-Prot: UBX2B_HUMAN, Q14CS0
    Similarity: Belongs to the NSFL1C family
    Similarity: Contains 1 SEP domain
    Similarity: Contains 1 UBX domain


    Find genes that share domains with UBXN2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBX2B_HUMAN, Q14CS0
    Function: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and
    endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex
    formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L.
    VCPIP1 is also required, but not its deubiquitinating activity

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with UBXN2B           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBXN2B
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate UBXN2B (see all 29):
    hsa-miR-576-3p hsa-miR-217 hsa-miR-3607-3p hsa-miR-300 hsa-miR-938 hsa-miR-301a hsa-miR-570 hsa-miR-374a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBX2B_HUMAN, Q14CS0: Nucleus (By similarity). Cytoplasm, cytosol (By similarity). Endoplasmic reticulum (By
    similarity). Golgi apparatus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    endoplasmic reticulum2
    golgi apparatus2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with UBXN2B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBXN2B
    Interactions:

        Search GeneGlobe Interaction Network for UBXN2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBXN2B (Q14CS03 ENSP000003825074) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCPP550723, ENSP000003517774I2D: score=3 STRING: ENSP00000351777
    VCPIP1Q96JH73, ENSP000003090314I2D: score=2 STRING: ENSP00000309031
    PLAAENSP000003804604STRING: ENSP00000380460
    YOD1ENSP000003268134STRING: ENSP00000326813
    ZFAND1ENSP000002206694STRING: ENSP00000220669
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBXN2B (UBX2B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBXN2B gene: 
    NM_001077619.1  

    Unigene Cluster for UBXN2B:

    UBX domain protein 2B
    Hs.155572  [show with all ESTs]
    Unigene Representative Sequence: NM_001077619
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399598(uc003xtl.3) ENST00000522978 ENST00000520732 ENST00000523409
    ENST00000521796
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate UBXN2B (see all 29):
    hsa-miR-576-3p hsa-miR-217 hsa-miR-3607-3p hsa-miR-300 hsa-miR-938 hsa-miR-301a hsa-miR-570 hsa-miR-374a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: UBXN2B (NM_001077619)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN2B
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat UBXN2B
      QuantiFast Probe-based Assays in human, mouse, rat UBXN2B

    Additional mRNA sequence: 

    AK054658.1 AK091561.1 AK126300.1 AL831990.2 AL833075.2 BC070386.1 BC113645.1 BX647876.2 
    U79282.1 

    7 DOTS entries:

    DT.214492  DT.100813407  DT.75119746  DT.91712440  DT.40229368  DT.40258251  DT.92056703 

    Selected AceView cDNA sequences (see all 131):

    BU616960 BQ027160 BQ937602 AA593630 AW474697 AK054658 BF508075 BU622593 
    AL138274 BM781756 AA489698 AI471953 BI492758 CA951114 AK126300 CB155575 
    BM818193 BM464311 CA941488 AI090885 BU146383 CA422938 BM557875 AA012939 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBXN2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTATGTAA
    UBXN2B Expression
    About this image

    UBXN2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBXN2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.155572
        Custom PCR Arrays for UBXN2B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBXN2B gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubxn2b1 , 5 UBX domain protein 2B1, 5 85.8(n)1
    85.5(a)1
      4 (2.91 cM)5
    680531  NM_026534.21  NP_080810.21 
     61910985 
    chicken
    (Gallus gallus)
    Aves UBXN2B1 UBX domain protein 2B 77.2(n)
    79.03(a)
      421135  NM_001031023.1  NP_001026194.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBXN2B6
    UBX domain protein 2B
    70(a)
    1 ↔ 1
    4(27593086-27606433)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.324742 Xenopus laevis transcribed sequence with weak similarity more 80.06(n)    AW643889.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p476
    CG423836
    --
    25(a)
    24(a)
    many ↔ many
    many ↔ many
    2R(3352523-3354236)
    2R(20311449-20312625)
    worm
    (Caenorhabditis elegans)
    Secernentea ubxn-26
    Protein UBXN-2, isoform a
    23(a)
    1 → many
    IV(2720323-2725858) WBGene00022381
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SHP16
    UBX (ubiquitin regulatory X) domain-containing pro...
    19(a)
    1 → many
    II(111437-112708) YBL058W
    rice
    (Oryza sativa)
    Liliopsida Os06g06346001 Os06g0634600 47.14(n)
    38.28(a)
      4341597  NM_001064673.1  NP_001058138.1 


    ENSEMBL Gene Tree for UBXN2B (if available)
    TreeFam Gene Tree for UBXN2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBXN2B gene
    UBXN2A2  NSFL1C2  
    2 SIMAP similar genes for UBXN2B using alignment to 4 protein entries:     UBX2B_HUMAN (see all proteins):
    UBXN2A    NSFL1C

    Find genes that share paralogs with UBXN2B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for UBXN2B
    PGOHUM00000233092


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBXN2B (see all 883)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1485809651,2
    --59321884(+) CTTATA/GTACTA 1 -- us2k10--------
    rs801203081,2
    C,F--59321886(+) TATATA/TCTAGG 1 -- us2k12Minor allele frequency- T:0.07NA EA 240
    rs1829588911,2
    --59321918(+) TGGAAA/GAGTAT 1 -- us2k10--------
    rs1872912851,2
    --59322146(+) ACGGAG/TTCTCT 1 -- us2k10--------
    rs1927711461,2
    --59322212(+) TTCCCG/TGGTTC 1 -- us2k10--------
    rs1848432731,2
    --59322222(+) CAAGCA/GATTCA 1 -- us2k10--------
    rs1877658491,2
    --59322227(+) AATTCA/TCCTGT 1 -- us2k10--------
    rs1927149071,2
    --59322232(+) ACCTGC/TCTCAG 1 -- us2k10--------
    rs1131037621,2
    C--59322284(+) CAGCTG/AATTTT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1463678581,2
    C--59322307(+) AGAGAC/TAGGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBXN2B (59323823 - 59364060 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for UBXN2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv890938CNV Gain21882294
    essv723CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBXN2B
    DNA2.0 Custom Variant and Variant Library Synthesis for UBXN2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610686    OMIM disorders: --


    Find genes that share disorders with UBXN2B           About GenesLikeMe

    Genetic Association Database (GAD): UBXN2B
    Human Genome Epidemiology (HuGE) Navigator: UBXN2B (1 document)

    Export disorders for UBXN2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBXN2B gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with UBXN2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis. (PubMed id 17141156)1, 2 Uchiyama K.... Kondo H. (Dev. Cell 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    5. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    6. The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A. (PubMed id 23649807)1 Kress E....Gotta M. (J. Cell Biol. 2013)
    7. Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. (PubMed id 23496005)1 Luca G....Tafti M. (J Sleep Res 2013)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 137886 HGNC: 27035 AceView: LOC137886 Ensembl:ENSG00000215114 euGenes: HUgn137886
    ECgene: UBXN2B H-InvDB: UBXN2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBXN2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBXN2B gene:
    Search GeneIP for patents involving UBXN2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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