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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBXN2A Gene

protein-coding   GIFtS: 45
GCID: GC02P024150

UBX Domain Protein 2A

(Previous name: UBX domain containing 4)
(Previous symbol: UBXD4)
  Search for UBXN2A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UBX Domain Protein 2A1 2
UBXD41 2 3
UBX Domain Containing 41 2
UBX Domain-Containing Protein 42 3
UBX Domain-Containing Protein 2A2

External Ids:    HGNC: 272651   Entrez Gene: 1653242   Ensembl: ENSG000001739607   UniProtKB: P685433   

Export aliases for UBXN2A gene to outside databases

Previous GC identifers: GC02P024003 GC02P023902


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UBXN2A Gene: 
UBXN2A (UBX domain protein 2A) is a protein-coding gene. GO annotations related to this gene include acetylcholine receptor binding. An important paralog of this gene is UBXN2B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBXN2A gene promoter:
         TBP   AhR   HOXA9   HOXA9B   AML1a   MIF-1   Meis-1b   AREB6   TFIID   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBXN2A promoter sequence
   Search SABiosciences Chromatin IP Primers for UBXN2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBXN2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p24.1

UBXN2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBXN2A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P024150:  view genomic region     (about GC identifiers)

Start:
24,150,155 bp from pter      End:
24,227,779 bp from pter
Size:
77,625 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBX2A_HUMAN, P68543 (See protein sequence)
Recommended Name: UBX domain-containing protein 2A  
Size: 259 amino acids; 29278 Da
Secondary accessions: A8K577 Q569G8

Explore the universe of human proteins at neXtProt for UBXN2A: NX_P68543

Explore proteomics data for UBXN2A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P68543

  • UBXN2A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBXN2A Protein Expression
    REFSEQ proteins: NP_859064.2  
    ENSEMBL proteins: 
     ENSP00000385525   ENSP00000312107   ENSP00000440533  

    Human Recombinant Protein Products for UBXN2A: 
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    Novus Biologicals UBXN2A Protein
    Novus Biologicals UBXN2A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBXN2A 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005801cis-Golgi network IEA--
    GO:0005829cytosol IEA--

    UBXN2A for ontologies           About GeneDecksing



    UBXN2A Antibody Products: 
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    Abcam antibodies for UBXN2A
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBXN: UBX domain containing

    2 InterPro protein domains:
     IPR012989 SEP_domain
     IPR001012 UBX

    Graphical View of Domain Structure for InterPro Entry P68543

    ProtoNet protein and cluster: P68543

    1 Blocks protein domain: IPB001012 UBX domain

    UniProtKB/Swiss-Prot: UBX2A_HUMAN, P68543
    Similarity: Contains 1 SEP domain
    Similarity: Contains 1 UBX domain


    UBXN2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0033130acetylcholine receptor binding IEA--
         
    UBXN2A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for UBXN2A:
     Synthetic lethal with Ras  Upregulation of NF-kappaB path 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBXN2A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBXN2A

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBXN2A 

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate UBXN2A (see all 21):
    hsa-miR-106a hsa-miR-605 hsa-miR-519a hsa-miR-93 hsa-miR-548x hsa-miR-3613-3p hsa-miR-3143 hsa-miR-17
    SwitchGear 3'UTR luciferase reporter plasmidUBXN2A 3' UTR sequence
    Inhib. RNA
    Products:
        
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                         Customized lentivirus expression plasmids for stable overexpression of UBXN2A 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN2A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBXN2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for UBXN2A (P685432, 3 ENSP000003121074) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHAXQ9H8142, 3, ENSP000002975404MINT-8276658 I2D: score=2 STRING: ENSP00000297540
    VCPP550722, 3, ENSP000003517774MINT-8276669 I2D: score=2 STRING: ENSP00000351777
    DBIP071082, 3, ENSP000003111174MINT-8276642 I2D: score=2 STRING: ENSP00000311117
    VCPIP1Q96JH73, ENSP000003090314I2D: score=2 STRING: ENSP00000309031
    SIRT1ENSP000002120154STRING: ENSP00000212015
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010468regulation of gene expression IEA--
    GO:0031396regulation of protein ubiquitination IEA--
    GO:0042176regulation of protein catabolic process IEA--

    UBXN2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBXN2A (UBX2A)

    Search CenterWatch for drugs/clinical trials and news about UBXN2A / UBX2A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBXN2A gene: 
    NM_181713.3  

    Unigene Cluster for UBXN2A:

    UBX domain protein 2A
    Hs.591576  [show with all ESTs]
    Unigene Representative Sequence: BC037901
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446425(uc002rem.3 uc010exy.3) ENST00000404924 ENST00000309033(uc002ren.3 uc010ykj.2)
    ENST00000479859 ENST00000535786
    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate UBXN2A (see all 21):
    hsa-miR-106a hsa-miR-605 hsa-miR-519a hsa-miR-93 hsa-miR-548x hsa-miR-3613-3p hsa-miR-3143 hsa-miR-17
    SwitchGear 3'UTR luciferase reporter plasmidUBXN2A 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBXN2A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBXN2A

    Additional mRNA sequence: 

    AK291192.1 AL832079.1 BC016364.1 BC037901.2 BC092484.1 BC093681.1 BC111997.1 BC143298.1 

    6 DOTS entries:

    DT.423492  DT.100740275  DT.91713266  DT.101973668  DT.101960707  DT.40246630 

    24/83 AceView cDNA sequences (see all 83):

    CB109184 BM451942 AL694062 AI149289 BU070305 W19529 BE882535 AI918322 
    BQ787308 N70658 N94958 T54751 AW207623 W19851 W19108 BQ441702 
    BX101903 AA431948 BC037901 BU753135 AI743403 N90041 AA256555 CF994708 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for UBXN2A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                    -                       -                     
    SP2:                                            -                     
    SP3:              -     -                       -                     
    SP4:                                                                  


    ECgene alternative splicing isoforms for UBXN2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBXN2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAACCAAAA
    UBXN2A Expression
    About this image


    See UBXN2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBXN2A

    SOURCE GeneReport for Unigene cluster: Hs.591576
        SABiosciences Expression via Pathway-Focused PCR Array including UBXN2A: 
              Cardiotoxicity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBXN2A gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubxn2a1 , 5 UBX domain protein 2A1, 5 87.76(n)1
    85.55(a)1
      12 (2.13 cM)5
    2173791  NM_145441.31  NP_663416.11 
     48790325 
    chicken
    (Gallus gallus)
    Aves UBXN2A1 UBX domain protein 2A 68.12(n)
    63.64(a)
      421973  NM_001031094.1  NP_001026265.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBXN2A6
    Uncharacterized protein
    57(a)
    1 ↔ 1
    1(140392915-140410501)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480547092   -- 73.55(n)    48054709 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005374781 UBX domain-containing protein 2A-like 53.14(n)
    44.77(a)
      100537478  XM_003200752.1  XP_003200800.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SHP16
    UBX (ubiquitin regulatory X) domain-containing pro...
    15(a)
    1 → many
    II(111437-112708)


    ENSEMBL Gene Tree for UBXN2A (if available)
    TreeFam Gene Tree for UBXN2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBXN2A gene
    UBXN2B2  NSFL1C2  
    2 SIMAP similar genes for UBXN2A using alignment to 2 protein entries:     UBX2A_HUMAN (see all proteins):
    NSFL1C    UBXN2B

    UBXN2A for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for UBXN2A
    PGOHUM00000234142 PGOHUM00000245562 PGOHUM00000235157 PGOHUM00000235557


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1204 SNPs in UBXN2A are shown (see all 1204)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs673498031,2
    C--24084320(+) GGGCT-/T/TT  
            
    TTTTT
    1 -- int10--------
    rs2000684411,2
    C--24161418(+) GCCCC-/CCCCT 
            
    CCCTT
    1 -- us2k10--------
    rs2012319431,2
    --24161419(+) CCCCC-/CCCT  
            
    CCCTT
    1 -- us2k10--------
    rs1889066241,2
    --24161521(+) AGTTGA/GAGGAC 1 -- us2k10--------
    rs1922442621,2
    --24161662(+) GAAATA/CAATTT 1 -- us2k10--------
    rs9258231,2
    C,H--24161788(+) CCTAAC/TGGGAT 1 -- us2k114Minor allele frequency- T:0.00MN NA WA CSA EA 559
    rs1499298161,2
    --24161829(+) CACGGG/TCTCAT 1 -- us2k10--------
    rs1827689391,2
    --24161833(+) GTCTCA/CTGAGC 1 -- us2k10--------
    rs1450265021,2
    --24161960(+) GCACTA/GAAGAC 1 -- us2k10--------
    rs75729491,2
    C,F,H--24162018(+) gattaC/Ttgcaa 1 -- us2k121Minor allele frequency- T:0.44NS EA NA WA 2348

    HapMap Linkage Disequilibrium report for UBXN2A (24150155 - 24227779 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for UBXN2A: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UBXN2A
    DNA2.0 Custom Variant and Variant Library Synthesis for UBXN2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBXN2A gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with UBXN2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. The ubiquitin-like (UBX)-domain-containing protein Ubx 2/Ubxd8 regulates lipid droplet homeostasis. (PubMed id 22454508)1 Wang C.W. and Lee S.C. (2012)
    4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    5. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. Genome-wide association study identifies genetic vari ants influencing F-cell levels in sickle-cell patients. (PubMed id 21326311)1 Bhatnagar P....Keefer J.R. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 165324 HGNC: 27265 AceView: UBXD4 Ensembl:ENSG00000173960 euGenes: HUgn165324
    ECgene: UBXN2A H-InvDB: UBXN2A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBXN2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBXN2A gene:
    Search GeneIP for patents involving UBXN2A

    GeneCards and IP:
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