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Aliases for UBXN2A Gene

Aliases for UBXN2A Gene

  • UBX Domain Protein 2A 2 3 5
  • UBX Domain-Containing Protein 4 3 4
  • UBX Domain Containing 4 2 3
  • UBXD4 3 4

External Ids for UBXN2A Gene

Previous HGNC Symbols for UBXN2A Gene

  • UBXD4

Previous GeneCards Identifiers for UBXN2A Gene

  • GC02P024003
  • GC02P024150

Summaries for UBXN2A Gene

GeneCards Summary for UBXN2A Gene

UBXN2A (UBX Domain Protein 2A) is a Protein Coding gene. GO annotations related to this gene include ubiquitin binding and acetylcholine receptor binding. An important paralog of this gene is UBXN2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN2A Gene

Genomics for UBXN2A Gene

Regulatory Elements for UBXN2A Gene

Enhancers for UBXN2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBXN2A on UCSC Golden Path with GeneCards custom track

Genomic Location for UBXN2A Gene

23,927,271 bp from pter
24,004,909 bp from pter
77,639 bases
Plus strand

Genomic View for UBXN2A Gene

Genes around UBXN2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN2A Gene

Proteins for UBXN2A Gene

  • Protein details for UBXN2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UBX domain-containing protein 2A
    Protein Accession:
    Secondary Accessions:
    • A8K577
    • B7ZKP8
    • Q569G8

    Protein attributes for UBXN2A Gene

    259 amino acids
    Molecular mass:
    29278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for UBXN2A Gene


neXtProt entry for UBXN2A Gene

Proteomics data for UBXN2A Gene at MOPED

Post-translational modifications for UBXN2A Gene

  • Ubiquitination at Lys 69 and Lys 205
  • Modification sites at PhosphoSitePlus

Other Protein References for UBXN2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBXN2A Gene

Domains & Families for UBXN2A Gene

Gene Families for UBXN2A Gene

Protein Domains for UBXN2A Gene


Suggested Antigen Peptide Sequences for UBXN2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SEP domain.
  • Contains 1 SEP domain.
  • Contains 1 UBX domain.
genes like me logo Genes that share domains with UBXN2A: view

Function for UBXN2A Gene

Gene Ontology (GO) - Molecular Function for UBXN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008599 protein phosphatase type 1 regulator activity IBA --
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with UBXN2A: view
genes like me logo Genes that share phenotypes with UBXN2A: view

Animal Model Products

CRISPR Products

miRNA for UBXN2A Gene

miRTarBase miRNAs that target UBXN2A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBXN2A Gene

Localization for UBXN2A Gene

Subcellular locations from

Jensen Localization Image for UBXN2A Gene COMPARTMENTS Subcellular localization image for UBXN2A gene
Compartment Confidence
cytosol 5
nucleus 4
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for UBXN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005801 cis-Golgi network IEA --
genes like me logo Genes that share ontologies with UBXN2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBXN2A Gene

Pathways & Interactions for UBXN2A Gene

SuperPathways for UBXN2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IBA --
GO:0031396 regulation of protein ubiquitination IEA --
GO:0031468 nuclear envelope reassembly IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0061025 membrane fusion IBA --
genes like me logo Genes that share ontologies with UBXN2A: view

No data available for Pathways by source and SIGNOR curated interactions for UBXN2A Gene

Drugs & Compounds for UBXN2A Gene

No Compound Related Data Available

Transcripts for UBXN2A Gene

Unigene Clusters for UBXN2A Gene

UBX domain protein 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN2A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - -
SP2: -
SP3: - - -

Relevant External Links for UBXN2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBXN2A Gene

mRNA expression in normal human tissues for UBXN2A Gene

Protein differential expression in normal tissues from HIPED for UBXN2A Gene

This gene is overexpressed in Heart (38.8), Platelet (16.2), and Placenta (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBXN2A Gene

SOURCE GeneReport for Unigene cluster for UBXN2A Gene Hs.591576

genes like me logo Genes that share expression patterns with UBXN2A: view

Protein tissue co-expression partners for UBXN2A Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBXN2A Gene

Orthologs for UBXN2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBXN2A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UBXN2A 35
  • 89.75 (n)
  • 90.66 (a)
  • 89 (a)
(Canis familiaris)
Mammalia UBXN2A 35
  • 90.4 (n)
  • 89.11 (a)
(Mus musculus)
Mammalia Ubxn2a 35
  • 87.76 (n)
  • 85.55 (a)
Ubxn2a 16
Ubxn2a 36
  • 82 (a)
(Pan troglodytes)
Mammalia UBXN2A 35
  • 99.49 (n)
  • 98.84 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Ubxn2a 35
  • 87.76 (n)
  • 86.33 (a)
(Monodelphis domestica)
Mammalia UBXN2A 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia UBXN2A 36
  • 68 (a)
(Gallus gallus)
Aves UBXN2A 35
  • 68.12 (n)
  • 63.64 (a)
  • 54 (a)
(Anolis carolinensis)
Reptilia UBXN2A 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn2a 35
  • 58.23 (n)
  • 50.2 (a)
(Danio rerio)
Actinopterygii ubxn2a 35
  • 53 (n)
  • 44.77 (a)
ubxn2a 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42383 36
  • 17 (a)
p47 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea ubxn-2 36
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SHP1 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2402 36
  • 22 (a)
Species with no ortholog for UBXN2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBXN2A Gene

Gene Tree for UBXN2A (if available)
Gene Tree for UBXN2A (if available)

Paralogs for UBXN2A Gene

Paralogs for UBXN2A Gene

(2) SIMAP similar genes for UBXN2A Gene using alignment to 2 proteins: Pseudogenes for UBXN2A Gene

genes like me logo Genes that share paralogs with UBXN2A: view

Variants for UBXN2A Gene

Sequence variations from dbSNP and Humsavar for UBXN2A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs925823 -- 23,938,918(+) CCTAA(C/T)GGGAT intron-variant, upstream-variant-2KB
rs3030907 -- 23,988,745(+) CCTCA(-/GATT)GATTG intron-variant
rs3088337 -- 24,000,072(-) TCTTT(C/T)GGAGA utr-variant-3-prime
rs6751655 -- 23,932,608(+) TCAAC(A/G)GGTTT intron-variant
rs6751955 -- 23,932,890(+) acaag(A/G)tcagg intron-variant

Variation tolerance for UBXN2A Gene

Residual Variation Intolerance Score: 52.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for UBXN2A Gene

Disorders for UBXN2A Gene

Relevant External Links for UBXN2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBXN2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBXN2A Gene

Publications for UBXN2A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. (PMID: 24625977) Sane S. … Rezvani K. (Cell Death Dis 2014) 3

Products for UBXN2A Gene

Sources for UBXN2A Gene