UBXN2A Gene
protein-coding GIFtS: 46
GCID: GC02P024150
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UBX domain protein 2A(Previous name: UBX domain containing 4 )
(Previous symbol: UBXD4)
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Aliases
for UBXN2A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| UBX Domain Protein 2A1 2 | | UBXD41 2 3 | | UBX Domain Containing 41 2 | | UBX Domain-Containing Protein 42 3 | | UBX Domain-Containing Protein 2A2 |
Export aliases for UBXN2A gene to outside databasesPrevious GC identifers: GC02P024003 GC02P023902 |
Summaries
for UBXN2A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for UBXN2A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBXN2A gene promoter:
TBP AhR HOXA9 HOXA9B AML1a MIF-1 Meis-1b AREB6 TFIID Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBXN2A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBXN2A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p24.1UBXN2A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P024150: view genomic region
(about GC identifiers)
Start:
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24,150,155 bp from pter |
End:
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24,227,779 bp from pter |
Size:
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77,625 bases |
Orientation:
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plus strand |
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Proteins
for UBXN2A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBX2A_HUMAN, P68543 (See
protein sequence)Recommended Name: UBX domain-containing protein 2A Size: 259 amino acids; 29278 Da
Secondary accessions: A8K577 Q569G8Explore the universe of human proteins at neXtProt for UBXN2A: NX_P68543
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P68543
UBXN2A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_859064.2
ENSEMBL proteins: ENSP00000385525 ENSP00000312107 ENSP00000440533
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
UBXN2A for ontologies About GeneDecksing
UBXN2A Antibody Products:
Assay Products for UBXN2A: |
Protein
Domains /
Families
for UBXN2A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBXN2A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P68543ProtoNet protein and cluster: P68543 1 Blocks protein family: IPB001012 UBX domain
UniProtKB/Swiss-Prot: UBX2A_HUMAN, P68543Similarity: Contains 1 SEP domainSimilarity: Contains 1 UBX domain |
Function
for UBXN2A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN2A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN2A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBXN2A (NM_181713) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBXN2A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN2A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN2A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0033130 | acetylcholine receptor binding |
IEA | -- |
UBXN2A for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for UBXN2A:
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Pathways & Interactions
for UBXN2A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBXN2A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for UBXN2A (P685432, 3 ENSP000003121074) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010468 | regulation of gene expression |
IEA | -- | | GO:0031396 | regulation of protein ubiquitination |
IEA | -- | | GO:0042176 | regulation of protein catabolic process |
IEA | -- |
UBXN2A for ontologies About GeneDecksing
|
Drugs & Compounds
for UBXN2A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBXN2A
Search CenterWatch for drugs/clinical trials and news about UBXN2A / UBX2A
|
Transcripts
for UBXN2A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBXN2A gene: NM_181713.3 Unigene Cluster for UBXN2A: UBX domain protein 2A Hs.591576 [show with all ESTs]Unigene Representative Sequence: BC0379015 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000446425(uc002rem.3 uc010exy.3) ENST00000404924 ENST00000309033(uc002ren.3 uc010ykj.2)
ENST00000479859 ENST00000535786
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN2A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN2A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBXN2A (NM_181713) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBXN2A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN2A |
Additional cDNA sequence: AK291192.1 AL832079.1 BC016364.1 BC037901.2 BC092484.1 BC093681.1 BC111997.1 BC143298.1 6 DOTS entries: DT.423492 DT.100740275 DT.91713266 DT.101973668 DT.101960707 DT.40246630 24/83 AceView cDNA sequences (see all 83): AW207623 N70658 AI149289 W19529 W19108 N94958 BU070305 BE882535 AI918322 T54751 W19851 AL694062 BM451942 CB109184 BQ787308 W37487 H97697 N90041 BQ021843 BU753135 AI031909 AA568122 AA255448 AA361563
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for UBXN2A About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 |
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| SP1: | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UBXN2A
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Expression
for UBXN2A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBXN2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAACCAAAA
About this image
See UBXN2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBXN2A
SOURCE GeneReport for Unigene cluster: Hs.591576
SABiosciences Expression via Pathway-Focused PCR Array including UBXN2A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBXN2A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBXN2A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBXN2A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBXN2A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN2A |
Orthologs
for UBXN2A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBXN2A gene from 8/27 species (see all 27) About this table
ENSEMBL Gene Tree for UBXN2A (if available)
TreeFam Gene Tree for UBXN2A (if available) |
Paralogs
for UBXN2A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBXN2A gene
- UBXN2B2 NSFL1C2
2 SIMAP similar genes for UBXN2A using alignment to 2 protein entries: UBX2A_HUMAN (see all proteins):NSFL1C UBXN2B
UBXN2A for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for UBXN2A
PGOHUM00000234142 PGOHUM00000245562 PGOHUM00000235157 PGOHUM00000235557
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Genomic Variants
for UBXN2A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBXN2A (24150155 - 24227779 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBXN2A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBXN2A |
|
Disorders
/ Diseases
for UBXN2A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBXN2A for disorders About GeneDecksing
1  disease for UBXN2A: About MalaCardsmalaria
Export disorders for UBXN2A gene to outside databases
|
Publications
for UBXN2A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBXN2A gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with UBXN2A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The ubiquitin-like (UBX)-domain-containing protein Ubx 2/Ubxd8 regulates lipid droplet homeostasis. (PubMed id 22454508)1 Wang C.W. and Lee S.C. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Genome-wide association study identifies genetic vari ants influencing F-cell levels in sickle-cell patients. (PubMed id 21326311)1 Bhatnagar P....Keefer J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Genome-wide association studies in an isolated founde r population from the Pacific Island of Kosrae. (PubMed id 19197348)1 Lowe J.K....Friedman J.M. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
|
External Searches for UBXN2A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBXN2A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBXN2A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBXN2A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBXN2A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBXN2A gene:
Search GeneIP for patents involving UBXN2A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBXN2A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UBXN2A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBXN2A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBXN2A | | | OriGene Protein Over-expression Lysate for UBXN2A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBXN2A | | OriGene 3'-UTR Clone for UBXN2A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN2A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN2A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for UBXN2A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBXN2A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBXN2A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBXN2A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBXN2A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBXN2A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBXN2A |
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| |  |  |  |  | | | | |
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 | | | UBXN2A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN2A |
|  |  |  | | | | Search ThermoFisher Antibodies for UBXN2A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN2A |
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