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Aliases for UBXN11 Gene

Aliases for UBXN11 Gene

  • UBX Domain Protein 11 2 3 5
  • Socius 2 3 4
  • Colorectal Tumor-Associated Antigen COA-1 3 4
  • UBX Domain-Containing Protein 5 3 4
  • UBXD5 3 4
  • SOC 3 4
  • Colorectal Tumor-Associated Antigen-1 3
  • UBX Domain-Containing Protein 11 3
  • UBX Domain Containing 5 2
  • PP2243 3
  • COA-1 3
  • SOCI 3

External Ids for UBXN11 Gene

Previous HGNC Symbols for UBXN11 Gene

  • UBXD5

Previous GeneCards Identifiers for UBXN11 Gene

  • GC01M026481
  • GC01M026607
  • GC01M024865

Summaries for UBXN11 Gene

Entrez Gene Summary for UBXN11 Gene

  • This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBXN11 Gene

UBXN11 (UBX Domain Protein 11) is a Protein Coding gene. GO annotations related to this gene include ubiquitin binding.

UniProtKB/Swiss-Prot for UBXN11 Gene

  • May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).

Gene Wiki entry for UBXN11 Gene

Additional gene information for UBXN11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN11 Gene

Genomics for UBXN11 Gene

Regulatory Elements for UBXN11 Gene

Enhancers for UBXN11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H026274 2 FANTOM5 Ensembl ENCODE dbSUPER 28.9 +34.5 34470 19 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 HMGN2 ARID1A LOC101928324 CD52 UBXN11 CEP85 GPN2 LIN28A NPM1P39 TRIM63
GH01H026348 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.1 -36.6 -36570 12 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 CD52 UBXN11 CEP85 CNKSR1 CRYBG2 LIN28A DHDDS SLC30A2 TRIM63 EXTL1
GH01H026313 1.4 FANTOM5 ENCODE 18.5 +0.2 194 8 HDGF PKNOX1 ATF1 SIN3A ARID4B BRCA1 ZNF2 ZNF766 GATA2 ZNF143 CD52 UBXN11 SH3BGRL3 ZNF683 CRYBG2 LIN28A CEP85 ZNF593 ENSG00000236782 FAM110D
GH01H026236 1.2 Ensembl ENCODE 17.5 +81.2 81242 2 HDAC1 HDGF NFRKB SIN3A BATF CHAMP1 ZNF366 FOS JUNB ZEB2 CD52 HMGN2 ARID1A LOC101928324 UBXN11 ENSG00000261349 CEP85 RPL17P9 GPN2 ZNF593
GH01H026618 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.6 -302.0 -302033 4 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 ZFP41 MEF2D ZNF610 ARID1A HMGN2 ACTG1P20 GPN2 ZNF593 AHDC1 GPATCH3 RPS6KA1 SELENON LOC101928324
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBXN11 on UCSC Golden Path with GeneCards custom track

Promoters for UBXN11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003534 163 401 HDAC1 HDGF LEF1 TBL1XR1 SIN3A ZNF766 CTBP1 GATA2 EGR1 POLR2A
ENSR00000250854 -637 401 MAX BATF ZFHX2 POLR2A EGR1 EED RUNX3 IKZF2 CHD2 EGR2

Genomic Location for UBXN11 Gene

Chromosome:
1
Start:
26,281,328 bp from pter
End:
26,318,363 bp from pter
Size:
37,036 bases
Orientation:
Minus strand

Genomic View for UBXN11 Gene

Genes around UBXN11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN11 Gene

Proteins for UBXN11 Gene

  • Protein details for UBXN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T124-UBX11_HUMAN
    Recommended name:
    UBX domain-containing protein 11
    Protein Accession:
    Q5T124
    Secondary Accessions:
    • D3DPK6
    • Q5T117
    • Q5T120
    • Q5T125
    • Q5T126
    • Q5T129
    • Q5T131
    • Q5T133
    • Q63HM6
    • Q71RB3
    • Q8IY27
    • Q8N1L6
    • Q8N9M4
    • Q8NA18
    • Q8NFE3
    • Q8NFE4
    • Q8NFE6

    Protein attributes for UBXN11 Gene

    Size:
    520 amino acids
    Molecular mass:
    57373 Da
    Quaternary structure:
    • Interacts with GNA12, GNA13, RND1, RND2 AND RND3.
    SequenceCaution:
    • Sequence=AAM74202.1; Type=Frameshift; Positions=190; Evidence={ECO:0000305}; Sequence=AAQ15261.1; Type=Frameshift; Positions=390; Evidence={ECO:0000305}; Sequence=CAI15828.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UBXN11 Gene

neXtProt entry for UBXN11 Gene

Post-translational modifications for UBXN11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for UBXN11 Gene

Domains & Families for UBXN11 Gene

Gene Families for UBXN11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBXN11 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBXN11: view

No data available for UniProtKB/Swiss-Prot for UBXN11 Gene

Function for UBXN11 Gene

Molecular function for UBXN11 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).

Phenotypes From GWAS Catalog for UBXN11 Gene

Gene Ontology (GO) - Molecular Function for UBXN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with UBXN11: view
genes like me logo Genes that share phenotypes with UBXN11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UBXN11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBXN11 Gene

Localization for UBXN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN11 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBXN11 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 3
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBXN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with UBXN11: view

Pathways & Interactions for UBXN11 Gene

SuperPathways for UBXN11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with UBXN11: view

No data available for Pathways by source and SIGNOR curated interactions for UBXN11 Gene

Drugs & Compounds for UBXN11 Gene

(3) Drugs for UBXN11 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for UBXN11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UBXN11: view

Transcripts for UBXN11 Gene

Unigene Clusters for UBXN11 Gene

UBX domain protein 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UBXN11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13a ·
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - - - - - -
SP7: - - -
SP8: -
SP9: - - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - - - - - - - -
SP17: - - -
SP18: - - -
SP19: -
SP20: - - - - - - - - - - - -
SP21: - - - - - - - - - - - -

ExUns: 13b ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for UBXN11 Gene

GeneLoc Exon Structure for
UBXN11
ECgene alternative splicing isoforms for
UBXN11

Expression for UBXN11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBXN11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBXN11 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for UBXN11 Gene

This gene is overexpressed in Testis (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UBXN11 Gene



Protein tissue co-expression partners for UBXN11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBXN11 Gene:

UBXN11

SOURCE GeneReport for Unigene cluster for UBXN11 Gene:

Hs.145061

Evidence on tissue expression from TISSUES for UBXN11 Gene

  • Intestine(4.2)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with UBXN11: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBXN11 Gene

Orthologs for UBXN11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBXN11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBXN11 33 34
  • 98.9 (n)
dog
(Canis familiaris)
Mammalia UBXN11 33 34
  • 85.06 (n)
mouse
(Mus musculus)
Mammalia Ubxn11 33 16 34
  • 83.88 (n)
cow
(Bos Taurus)
Mammalia UBXN11 33 34
  • 83.86 (n)
rat
(Rattus norvegicus)
Mammalia Ubxn11 33
  • 83.55 (n)
oppossum
(Monodelphis domestica)
Mammalia UBXN11 34
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBXN11 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBXN11 33 34
  • 55.85 (n)
lizard
(Anolis carolinensis)
Reptilia UBXN11 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn11 33
  • 49.56 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-11i5.1 33
  • 48.99 (n)
UBXN11 34
  • 35 (a)
OneToOne
Species where no ortholog for UBXN11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBXN11 Gene

ENSEMBL:
Gene Tree for UBXN11 (if available)
TreeFam:
Gene Tree for UBXN11 (if available)

Paralogs for UBXN11 Gene

No data available for Paralogs for UBXN11 Gene

Variants for UBXN11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN11 Gene

UBX11_HUMAN-Q5T124
The number of repeats is polymorphic and varies from 1 to 4.

Sequence variations from dbSNP and Humsavar for UBXN11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000016449 -- 26,301,969(+) TTAGG(C/T)GGGAA intron-variant
rs1000055212 -- 26,304,491(+) CTTAC(A/G)CCTAT intron-variant
rs1000162128 -- 26,308,410(+) TCCAC(A/G)CTCTT intron-variant, upstream-variant-2KB
rs1000217951 -- 26,285,662(+) ACATT(C/T)AGAGT intron-variant
rs1000347906 -- 26,301,960(+) AGCAG(A/T)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBXN11 Gene

Variant ID Type Subtype PubMed ID
esv2745674 CNV deletion 23290073
esv3559826 CNV deletion 23714750
esv3585537 CNV loss 21293372

Variation tolerance for UBXN11 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.23; 81.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBXN11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBXN11

Disorders for UBXN11 Gene

Relevant External Links for UBXN11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBXN11

No disorders were found for UBXN11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBXN11 Gene

Publications for UBXN11 Gene

  1. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. (PMID: 11940653) Katoh H … Negishi M (Molecular and cellular biology 2002) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Identification of a colorectal tumor-associated antigen (COA-1) recognized by CD4(+) T lymphocytes. (PMID: 14583468) Maccalli C … Robbins PF (Cancer research 2003) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for UBXN11 Gene

Sources for UBXN11 Gene

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