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Aliases for UBXN11 Gene

Aliases for UBXN11 Gene

  • UBX Domain Protein 11 2 3 5
  • Socius 2 3 4
  • Colorectal Tumor-Associated Antigen COA-1 3 4
  • UBX Domain-Containing Protein 5 3 4
  • UBXD5 3 4
  • SOC 3 4
  • Colorectal Tumor-Associated Antigen-1 3
  • UBX Domain Containing 5 2
  • PP2243 3
  • COA-1 3
  • SOCI 3

External Ids for UBXN11 Gene

Previous HGNC Symbols for UBXN11 Gene

  • UBXD5

Previous GeneCards Identifiers for UBXN11 Gene

  • GC01M026481
  • GC01M026607
  • GC01M024865

Summaries for UBXN11 Gene

Entrez Gene Summary for UBXN11 Gene

  • This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBXN11 Gene

UBXN11 (UBX Domain Protein 11) is a Protein Coding gene. GO annotations related to this gene include ubiquitin binding.

UniProtKB/Swiss-Prot for UBXN11 Gene

  • May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).

Gene Wiki entry for UBXN11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN11 Gene

Genomics for UBXN11 Gene

Regulatory Elements for UBXN11 Gene

Promoters for UBXN11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBXN11 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBXN11 Gene

Chromosome:
1
Start:
26,281,328 bp from pter
End:
26,318,363 bp from pter
Size:
37,036 bases
Orientation:
Minus strand

Genomic View for UBXN11 Gene

Genes around UBXN11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN11 Gene

Proteins for UBXN11 Gene

  • Protein details for UBXN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T124-UBX11_HUMAN
    Recommended name:
    UBX domain-containing protein 11
    Protein Accession:
    Q5T124
    Secondary Accessions:
    • D3DPK6
    • Q5T117
    • Q5T120
    • Q5T125
    • Q5T126
    • Q5T129
    • Q5T131
    • Q5T133
    • Q63HM6
    • Q71RB3
    • Q8IY27
    • Q8N1L6
    • Q8N9M4
    • Q8NA18
    • Q8NFE3
    • Q8NFE4
    • Q8NFE6

    Protein attributes for UBXN11 Gene

    Size:
    520 amino acids
    Molecular mass:
    57373 Da
    Quaternary structure:
    • Interacts with GNA12, GNA13, RND1, RND2 AND RND3.
    SequenceCaution:
    • Sequence=AAM74202.1; Type=Frameshift; Positions=190; Evidence={ECO:0000305}; Sequence=AAQ15261.1; Type=Frameshift; Positions=390; Evidence={ECO:0000305}; Sequence=CAI15828.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UBXN11 Gene

neXtProt entry for UBXN11 Gene

Proteomics data for UBXN11 Gene at MOPED

Post-translational modifications for UBXN11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for UBXN11 Gene

Domains & Families for UBXN11 Gene

Gene Families for UBXN11 Gene

Protein Domains for UBXN11 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T124

UniProtKB/Swiss-Prot:

UBX11_HUMAN :
  • Contains 1 SEP domain.
Domain:
  • Contains 1 SEP domain.
  • Contains 1 UBX domain.
genes like me logo Genes that share domains with UBXN11: view

Function for UBXN11 Gene

Molecular function for UBXN11 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).
genes like me logo Genes that share phenotypes with UBXN11: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBXN11 Gene

Localization for UBXN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN11 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBXN11 Gene COMPARTMENTS Subcellular localization image for UBXN11 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 3
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for UBXN11 Gene

Pathways & Interactions for UBXN11 Gene

SuperPathways for UBXN11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBXN11 Gene

Drugs & Compounds for UBXN11 Gene

(2) Drugs for UBXN11 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for UBXN11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UBXN11: view

Transcripts for UBXN11 Gene

Unigene Clusters for UBXN11 Gene

UBX domain protein 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13a ·
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - - - - - -
SP7: - - -
SP8: -
SP9: - - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - - - - - - - -
SP17: - - -
SP18: - - -
SP19: -
SP20: - - - - - - - - - - - -
SP21: - - - - - - - - - - - -

ExUns: 13b ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for UBXN11 Gene

GeneLoc Exon Structure for
UBXN11
ECgene alternative splicing isoforms for
UBXN11

Expression for UBXN11 Gene

mRNA expression in normal human tissues for UBXN11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBXN11 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for UBXN11 Gene

This gene is overexpressed in Testis (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UBXN11 Gene



SOURCE GeneReport for Unigene cluster for UBXN11 Gene Hs.145061

genes like me logo Genes that share expression patterns with UBXN11: view

Protein tissue co-expression partners for UBXN11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UBXN11 Gene

Orthologs for UBXN11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBXN11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBXN11 35
  • 98.9 (n)
  • 98.77 (a)
UBXN11 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBXN11 36
  • 76 (a)
OneToOne
UBXN11 35
  • 83.86 (n)
  • 80.97 (a)
dog
(Canis familiaris)
Mammalia UBXN11 35
  • 85.06 (n)
  • 80.76 (a)
UBXN11 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubxn11 16
Ubxn11 36
  • 81 (a)
OneToOne
Ubxn11 35
  • 83.88 (n)
  • 82.65 (a)
oppossum
(Monodelphis domestica)
Mammalia UBXN11 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBXN11 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubxn11 35
  • 83.55 (n)
  • 81.88 (a)
chicken
(Gallus gallus)
Aves UBXN11 35
  • 55.85 (n)
  • 45.91 (a)
UBXN11 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBXN11 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn11 35
  • 49.56 (n)
  • 42.17 (a)
zebrafish
(Danio rerio)
Actinopterygii UBXN11 36
  • 35 (a)
OneToOne
si:ch211-11i5.1 35
  • 48.99 (n)
  • 39.15 (a)
Species with no ortholog for UBXN11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBXN11 Gene

ENSEMBL:
Gene Tree for UBXN11 (if available)
TreeFam:
Gene Tree for UBXN11 (if available)

Paralogs for UBXN11 Gene

No data available for Paralogs for UBXN11 Gene

Variants for UBXN11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN11 Gene

Q5T124-UBX11_HUMAN
The number of repeats is polymorphic and varies from 1 to 4.

Sequence variations from dbSNP and Humsavar for UBXN11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6695966 - 26,294,270(+) TGCTC(C/T)CTGAG intron-variant, reference, missense
rs4332350 - 26,284,400(+) GCATC(A/C/T)GCTGC reference, missense
VAR_031862 -
VAR_052689 -, -
rs2276712 -- 26,300,987(+) TCTTC(C/G/T)GAGCC intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for UBXN11 Gene

Variant ID Type Subtype PubMed ID
esv2745674 CNV Deletion 23290073

Variation tolerance for UBXN11 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.23; 81.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBXN11 Gene

HapMap Linkage Disequilibrium report
UBXN11

Disorders for UBXN11 Gene

Relevant External Links for UBXN11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBXN11

No disorders were found for UBXN11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBXN11 Gene

Publications for UBXN11 Gene

  1. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. (PMID: 11940653) Katoh H. … Negishi M. (Mol. Cell. Biol. 2002) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for UBXN11 Gene

Sources for UBXN11 Gene

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