Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBXN11 Gene

Aliases for UBXN11 Gene

  • UBX Domain Protein 11 2 3
  • Socius 2 3 4
  • Colorectal Tumor-Associated Antigen COA-1 3 4
  • UBX Domain-Containing Protein 5 3 4
  • UBXD5 3 4
  • SOC 3 4
  • Colorectal Tumor-Associated Antigen-1 3
  • UBX Domain-Containing Protein 11 3
  • UBX Domain Containing 5 2
  • PP2243 3
  • COA-1 3
  • SOCI 3

External Ids for UBXN11 Gene

Previous HGNC Symbols for UBXN11 Gene

  • UBXD5

Previous GeneCards Identifiers for UBXN11 Gene

  • GC01M026481
  • GC01M026607
  • GC01M024865

Summaries for UBXN11 Gene

Entrez Gene Summary for UBXN11 Gene

  • This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBXN11 Gene

UBXN11 (UBX Domain Protein 11) is a Protein Coding gene. Diseases associated with UBXN11 include choanal atresia and osteoporosis.

UniProtKB/Swiss-Prot for UBXN11 Gene

  • May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).

Gene Wiki entry for UBXN11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN11 Gene

Genomics for UBXN11 Gene

Regulatory Elements for UBXN11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBXN11 Gene

Start:
26,281,328 bp from pter
End:
26,318,363 bp from pter
Size:
37,036 bases
Orientation:
Minus strand

Genomic View for UBXN11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBXN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN11 Gene

Proteins for UBXN11 Gene

  • Protein details for UBXN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T124-UBX11_HUMAN
    Recommended name:
    UBX domain-containing protein 11
    Protein Accession:
    Q5T124
    Secondary Accessions:
    • D3DPK6
    • Q5T117
    • Q5T120
    • Q5T125
    • Q5T126
    • Q5T129
    • Q5T131
    • Q5T133
    • Q63HM6
    • Q71RB3
    • Q8IY27
    • Q8N1L6
    • Q8N9M4
    • Q8NA18
    • Q8NFE3
    • Q8NFE4
    • Q8NFE6

    Protein attributes for UBXN11 Gene

    Size:
    520 amino acids
    Molecular mass:
    57373 Da
    Quaternary structure:
    • Interacts with GNA12, GNA13, RND1, RND2 AND RND3.
    SequenceCaution:
    • Sequence=AAM74202.1; Type=Frameshift; Positions=190; Evidence={ECO:0000305}; Sequence=AAQ15261.1; Type=Frameshift; Positions=390; Evidence={ECO:0000305}; Sequence=CAI15828.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UBXN11 Gene

neXtProt entry for UBXN11 Gene

Proteomics data for UBXN11 Gene at MOPED

Post-translational modifications for UBXN11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for UBXN11 Gene

Domains for UBXN11 Gene

Gene Families for UBXN11 Gene

HGNC:
  • UBXN :UBX domain containing

Protein Domains for UBXN11 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T124

UniProtKB/Swiss-Prot:

UBX11_HUMAN :
  • Q5T124
Domain:
  • Contains 1 SEP domain.
  • Contains 1 UBX domain.
genes like me logo Genes that share domains with UBXN11: view

Function for UBXN11 Gene

Molecular function for UBXN11 Gene

UniProtKB/Swiss-Prot Function: May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).

Gene Ontology (GO) - Molecular Function for UBXN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with UBXN11: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBXN11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UBXN11 Gene

Localization for UBXN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN11 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBXN11 Gene COMPARTMENTS Subcellular localization image for UBXN11 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UBXN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with UBXN11: view

Pathways for UBXN11 Gene

SuperPathways for UBXN11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with UBXN11: view

No data available for Pathways by source for UBXN11 Gene

Compounds for UBXN11 Gene

(5) Novoseek inferred chemical compound relationships for UBXN11 Gene

Compound -log(P) Hits PubMed IDs
pyridinoline 59.9 2
deoxypyridinoline 55.5 2
calcium 37.4 3
creatinine 25.9 4
zinc 12.6 1
genes like me logo Genes that share compounds with UBXN11: view

Transcripts for UBXN11 Gene

Unigene Clusters for UBXN11 Gene

UBX domain protein 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBXN11

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for UBXN11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12 ^ 13a ·
SP1: - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - - - - - -
SP7: - - -
SP8: -
SP9: - - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - - - - - - - -
SP17: - - -
SP18: - - -
SP19: -
SP20: - - - - - - - - - - - -
SP21: - - - - - - - - - - - -

ExUns: 13b ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for UBXN11 Gene

GeneLoc Exon Structure for
UBXN11
ECgene alternative splicing isoforms for
UBXN11

Expression for UBXN11 Gene

mRNA expression in normal human tissues for UBXN11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBXN11 Gene

This gene is overexpressed in Whole Blood (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UBXN11 Gene

SOURCE GeneReport for Unigene cluster for UBXN11 Gene Hs.145061

genes like me logo Genes that share expressions with UBXN11: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UBXN11 Gene

Orthologs for UBXN11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBXN11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBXN11 35
  • 98.9 (n)
  • 98.77 (a)
UBXN11 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBXN11 35
  • 83.86 (n)
  • 80.97 (a)
UBXN11 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBXN11 35
  • 85.06 (n)
  • 80.76 (a)
UBXN11 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubxn11 35
  • 83.88 (n)
  • 82.65 (a)
Ubxn11 16
Ubxn11 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBXN11 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBXN11 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubxn11 35
  • 83.55 (n)
  • 81.88 (a)
chicken
(Gallus gallus)
Aves UBXN11 35
  • 55.85 (n)
  • 45.91 (a)
UBXN11 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBXN11 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn11 35
  • 49.56 (n)
  • 42.17 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-11i5.1 35
  • 48.99 (n)
  • 39.15 (a)
UBXN11 36
  • 35 (a)
OneToOne
Species with no ortholog for UBXN11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBXN11 Gene

ENSEMBL:
Gene Tree for UBXN11 (if available)
TreeFam:
Gene Tree for UBXN11 (if available)

Paralogs for UBXN11 Gene

No data available for Paralogs for UBXN11 Gene

Variants for UBXN11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN11 Gene

Q5T124-UBX11_HUMAN
The number of repeats is polymorphic and varies from 1 to 4

Sequence variations from dbSNP and Humsavar for UBXN11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1134580 -- 26,282,392(-) CCCGG(C/T)CCCGG synonymous-codon, reference
rs1134581 -- 26,282,388(-) GTCCC(A/G)GCCCC missense, reference
rs1134582 -- 26,282,386(-) CCCGG(C/T)CCCAG reference, synonymous-codon
rs1134583 -- 26,282,382(-) GCCCC(A/T)GTCCC reference, missense
rs1134584 -- 26,282,337(-) CCGGC(C/T)CCAGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for UBXN11 Gene

Variant ID Type Subtype PubMed ID
esv2745674 CNV Deletion 23290073

Relevant External Links for UBXN11 Gene

HapMap Linkage Disequilibrium report
UBXN11

Disorders for UBXN11 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for UBXN11 Gene including...

Search for UBXN11 Gene in MalaCards »

(2) University of Copenhagen DISEASES for UBXN11 Gene

(1) Novoseek inferred disease relationships for UBXN11 Gene

Disease -log(P) Hits PubMed IDs
osteoporosis 29.4 1
genes like me logo Genes that share disorders with UBXN11: view

No data available for UniProtKB/Swiss-Prot for UBXN11 Gene

Publications for UBXN11 Gene

  1. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. (PMID: 11940653) Katoh H. … Negishi M. (Mol. Cell. Biol. 2002) 2 3 4
  2. Identification of a colorectal tumor-associated antigen (COA-1) recognized by CD4(+) T lymphocytes. (PMID: 14583468) Maccalli C. … Robbins P.F. (Cancer Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for UBXN11 Gene

  • antibodies-online proteins for UBXN11
  • antibodies-online antibodies for UBXN11
  • antibodies-online kits for UBXN11

Sources for UBXN11 Gene

Back to Top

Content