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Aliases for UBXN10 Gene

Aliases for UBXN10 Gene

  • UBX Domain Protein 10 2 3 5
  • UBX Domain-Containing Protein 3 3 4
  • UBX Domain Containing 3 2 3
  • UBXD3 3 4
  • UBX Domain-Containing Protein 10 3

External Ids for UBXN10 Gene

Previous HGNC Symbols for UBXN10 Gene

  • UBXD3

Previous GeneCards Identifiers for UBXN10 Gene

  • GC01P020387
  • GC01P020512
  • GC01P018758

Summaries for UBXN10 Gene

GeneCards Summary for UBXN10 Gene

UBXN10 (UBX Domain Protein 10) is a Protein Coding gene.

UniProtKB/Swiss-Prot for UBXN10 Gene

  • VCP/p97-binding protein required for ciliogenesis (PubMed:26389662). Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia (PubMed:26389662). UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97 (PubMed:26389662).

Additional gene information for UBXN10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN10 Gene

Genomics for UBXN10 Gene

GeneHancer (GH) Regulatory Elements for UBXN10 Gene

Promoters and enhancers for UBXN10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I020184 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 578.5 +2.9 2945 3.8 HDGF FOXA2 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A YY1 POLR2B UBXN10 UBXN10-AS1 UBR4 HP1BP3
GH01I020185 Enhancer 0.9 ENCODE dbSUPER 556.8 +0.8 821 0.2 NFIA RXRA HLF MAX RAD21 FOXA1 GABPA ZNF395 YY1 JUND UBXN10 UBXN10-AS1
GH01I020210 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.2 +28.7 28692 3.1 HDAC1 PKNOX1 SMAD1 NFIB RAD21 ETS1 ZNF766 ZNF143 FOS ZNF654 LOC105376826 CAMK2N1 MUL1 VWA5B1 ENSG00000226664 UBXN10 LOC105376825
GH01I020198 Enhancer 0.9 dbSUPER 12.1 +16.0 15959 1.2 PKNOX1 SMAD1 ATF1 ARNT TCF12 ZNF766 GATA2 FOS ATF7 NCOA1 LOC105376825 UBXN10 LOC105376826
GH01I020008 Enhancer 1 FANTOM5 ENCODE 5.7 -174.6 -174561 1.3 HDAC1 PKNOX1 ATF1 CEBPG BMI1 E4F1 ZBTB40 FOSL1 CTBP1 ZNF316 PLA2G5 UBXN10 PIR59989
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBXN10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBXN10 gene promoter:

Genomic Locations for UBXN10 Gene

Genomic Locations for UBXN10 Gene
chr1:20,183,302-20,196,048
(GRCh38/hg38)
Size:
12,747 bases
Orientation:
Plus strand
chr1:20,512,578-20,522,541
(GRCh37/hg19)

Genomic View for UBXN10 Gene

Genes around UBXN10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN10 Gene

Proteins for UBXN10 Gene

  • Protein details for UBXN10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LJ8-UBX10_HUMAN
    Recommended name:
    UBX domain-containing protein 10
    Protein Accession:
    Q96LJ8
    Secondary Accessions:
    • Q5R386

    Protein attributes for UBXN10 Gene

    Size:
    280 amino acids
    Molecular mass:
    30811 Da
    Quaternary structure:
    • Interacts with CLUAP1; the interaction is direct and mediates interaction with the intraflagellar transport complex B (IFT-B) (PubMed:26389662). Interacts with VCP; the interaction is direct (PubMed:26389662).

neXtProt entry for UBXN10 Gene

Post-translational modifications for UBXN10 Gene

No Post-translational modifications

Other Protein References for UBXN10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBXN10 Gene

Domains & Families for UBXN10 Gene

Gene Families for UBXN10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBXN10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UBXN10 Gene

Graphical View of Domain Structure for InterPro Entry

Q96LJ8

UniProtKB/Swiss-Prot:

UBX10_HUMAN :
  • Belongs to the UBXN10 family.
Family:
  • Belongs to the UBXN10 family.
genes like me logo Genes that share domains with UBXN10: view

Function for UBXN10 Gene

Molecular function for UBXN10 Gene

UniProtKB/Swiss-Prot Function:
VCP/p97-binding protein required for ciliogenesis (PubMed:26389662). Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia (PubMed:26389662). UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97 (PubMed:26389662).

Gene Ontology (GO) - Molecular Function for UBXN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26389662
genes like me logo Genes that share ontologies with UBXN10: view
genes like me logo Genes that share phenotypes with UBXN10: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UBXN10 Gene

Localization for UBXN10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN10 Gene

Cell projection, cilium. Note=Recruited to cilia in a VCP-dependent manner. {ECO:0000269 PubMed:26389662}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBXN10 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (1)
  • Nucleoplasm (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBXN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IDA,IEA 26389662
GO:0030992 colocalizes_with intraciliary transport particle B IDA 26389662
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with UBXN10: view

Pathways & Interactions for UBXN10 Gene

SuperPathways for UBXN10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0060271 cilium assembly IDA 26389662
genes like me logo Genes that share ontologies with UBXN10: view

No data available for Pathways by source and SIGNOR curated interactions for UBXN10 Gene

Drugs & Compounds for UBXN10 Gene

No Compound Related Data Available

Transcripts for UBXN10 Gene

mRNA/cDNA for UBXN10 Gene

Unigene Clusters for UBXN10 Gene

UBX domain protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN10 Gene

No ASD Table

Relevant External Links for UBXN10 Gene

GeneLoc Exon Structure for
UBXN10
ECgene alternative splicing isoforms for
UBXN10

Expression for UBXN10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBXN10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBXN10 Gene

This gene is overexpressed in Colon - Sigmoid (x5.0) and Testis (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of UBXN10 Gene:

UBXN10

SOURCE GeneReport for Unigene cluster for UBXN10 Gene:

Hs.432503
genes like me logo Genes that share expression patterns with UBXN10: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBXN10 Gene

Orthologs for UBXN10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBXN10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBXN10 33 34
  • 98.93 (n)
cow
(Bos Taurus)
Mammalia UBXN10 33 34
  • 77.9 (n)
dog
(Canis familiaris)
Mammalia UBXN10 33 34
  • 77.74 (n)
mouse
(Mus musculus)
Mammalia Ubxn10 33 16 34
  • 74.55 (n)
rat
(Rattus norvegicus)
Mammalia Ubxn10 33
  • 74.29 (n)
oppossum
(Monodelphis domestica)
Mammalia UBXN10 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBXN10 33 34
  • 58.53 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493414 33
  • 57.01 (n)
zebrafish
(Danio rerio)
Actinopterygii ubxn10 33 34
  • 51.83 (n)
Species where no ortholog for UBXN10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBXN10 Gene

ENSEMBL:
Gene Tree for UBXN10 (if available)
TreeFam:
Gene Tree for UBXN10 (if available)

Paralogs for UBXN10 Gene

No data available for Paralogs for UBXN10 Gene

Variants for UBXN10 Gene

Sequence variations from dbSNP and Humsavar for UBXN10 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000058678 -- 20,182,799(+) A/G upstream_transcript_variant
rs1000301523 -- 20,191,765(+) G/A 3_prime_UTR_variant
rs1000417359 -- 20,192,157(+) G/A 3_prime_UTR_variant
rs1000616421 -- 20,190,012(+) C/T intron_variant
rs1000644567 -- 20,184,118(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for UBXN10 Gene

Variant ID Type Subtype PubMed ID
nsv545731 CNV gain 21841781

Variation tolerance for UBXN10 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBXN10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBXN10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN10 Gene

Disorders for UBXN10 Gene

Additional Disease Information for UBXN10

No disorders were found for UBXN10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBXN10 Gene

Publications for UBXN10 Gene

  1. Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. (PMID: 26389662) Raman M … Harper JW (Nature cell biology 2015) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 58

Products for UBXN10 Gene

Sources for UBXN10 Gene

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