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UBXN10 Gene

protein-coding   GIFtS: 40
GCID: GC01P020512

UBX Domain Protein 10

(Previous name: UBX domain containing 3)
(Previous symbol: UBXD3)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UBX Domain Protein 101 2
UBXD31 2 3
UBX Domain Containing 31 2
UBX Domain-Containing Protein 32 3
UBX Domain-Containing Protein 102

External Ids:    HGNC: 263541   Entrez Gene: 1277332   Ensembl: ENSG000001625437   UniProtKB: Q96LJ83   

Export aliases for UBXN10 gene to outside databases

Previous GC identifers: GC01P020387 GC01P018758


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UBXN10 Gene:
UBXN10 (UBX domain protein 10) is a protein-coding gene. Diseases associated with UBXN10 include retinitis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBXN10 gene promoter:
         Egr-3   AML1a   Nkx2-2   MEF-2   E47   C/EBPalpha   CHOP-10   MEF-2A   HEN1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBXN10 promoter sequence
   Search Chromatin IP Primers for UBXN10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBXN10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.13

UBXN10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBXN10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P020512:  view genomic region     (about GC identifiers)

Start:
20,512,578 bp from pter      End:
20,522,541 bp from pter
Size:
9,964 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UBX10_HUMAN, Q96LJ8 (See protein sequence)
Recommended Name: UBX domain-containing protein 10  
Size: 280 amino acids; 30811 Da
Secondary accessions: Q5R386

Explore the universe of human proteins at neXtProt for UBXN10: NX_Q96LJ8

Explore proteomics data for UBXN10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UBXN10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689589.1  
    ENSEMBL proteins: 
     ENSP00000364240  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBXN: UBX domain containing

    1 InterPro protein domain:
     IPR001012 UBX

    Graphical View of Domain Structure for InterPro Entry Q96LJ8

    ProtoNet protein and cluster: Q96LJ8

    1 Blocks protein domain: IPB001012 UBX domain

    UniProtKB/Swiss-Prot: UBX10_HUMAN, Q96LJ8
    Similarity: Contains 1 UBX domain


    UBXN10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    UBXN10 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-miR-1290 hsa-miR-140-3p hsa-miR-330-5p hsa-miR-15a hsa-miR-497 hsa-miR-942 hsa-miR-361-3p hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidUBXN10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UBXN10

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBXN10
    Interactions:

        Search GeneGlobe Interaction Network for UBXN10

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for UBXN10 (Q96LJ83 ENSP000003642404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UFD1LQ928903, ENSP000002632024I2D: score=2 STRING: ENSP00000263202
    VCPP550723, ENSP000003517774I2D: score=2 STRING: ENSP00000351777
    NPLOC4Q8TAT63, ENSP000003314874I2D: score=2 STRING: ENSP00000331487
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBXN10 (UBX10)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UBXN10 gene: 
    NM_152376.3  

    Unigene Cluster for UBXN10:

    UBX domain protein 10
    Hs.432503  [show with all ESTs]
    Unigene Representative Sequence: BX648631
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375099(uc001bdb.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate UBXN10 (see all 13):
    hsa-miR-1290 hsa-miR-140-3p hsa-miR-330-5p hsa-miR-15a hsa-miR-497 hsa-miR-942 hsa-miR-361-3p hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidUBXN10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UBXN10
    Predesigned siRNA for gene silencing in human, mouse, rat UBXN10
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBXN10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN10
    Primer
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    OriGene qPCR primer pairs and template standards for UBXN10
    OriGene qSTAR qPCR primer pairs in human, mouse for UBXN10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBXN10
      QuantiTect SYBR Green Assays in human, mouse, rat UBXN10
      QuantiFast Probe-based Assays in human, mouse, rat UBXN10

    Additional mRNA sequence: 

    AK025931.1 AK058158.1 BC036417.1 BC047428.1 BX648631.1 

    1 DOTS entry:

    DT.100010169 

    Selected AceView cDNA sequences (see all 62):

    AW269931 BQ045479 AI968729 AA234366 AI261811 AI635003 BX648631 AI245236 
    AI344623 AK058158 BP369047 BX091133 BQ689999 AI733818 BM828646 AA644012 
    NM_152376 AA034080 CB047927 AK025931 BE855973 BG721631 BP370417 CA311417 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBXN10 expression in normal human tissues (normalized intensities)      UBXN10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UBXN10 Expression
    About this image


    UBXN10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Zeugopod Long Bone
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
     
     Eye (Sensory Organs)
             Retina
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    UBXN10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBXN10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.432503
        Custom PCR Arrays for UBXN10
    Primer
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    OriGene qPCR primer pairs and template standards for UBXN10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for UBXN10 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubxn101 , 5 UBX domain protein 101, 5 74.55(n)1
    70.18(a)1
      4 (70.53 cM)5
    2121901  NM_001285930.11  NP_001272859.11 
     1387098375 
    chicken
    (Gallus gallus)
    Aves UBXN101 UBX domain protein 10 58.53(n)
    51.16(a)
      771670  NM_001278045.1  NP_001264974.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004934141 UBX domain-containing protein 10-like 57.01(n)
    50.93(a)
      100493414  XM_002941956.2  XP_002942002.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ubxn101 UBX domain protein 10 51.83(n)
    41.5(a)
      751736  NM_001045446.2  NP_001038911.1 


    ENSEMBL Gene Tree for UBXN10 (if available)
    TreeFam Gene Tree for UBXN10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBXN10 (see all 213)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469060051,2
    --20510679(+) GCGTGC/GGTGCG 1 -- us2k10--------
    rs124093501,2
    C,F,H--20510681(+) GTGCGT/CGCGCA 1 -- us2k18Minor allele frequency- C:0.43WA NA CSA EA 371
    rs57728871,2
    C--20510690(+) acacg-/CACA/ 
    CACACACA
    cacac
    1 -- us2k10--------
    rs341465581,2
    C--20510691(+) CACGC-/CA    
       
    /CACA
    ACACA
    1 -- us2k10--------
    rs1897586281,2
    --20510718(+) CACACA/TCACGG 1 -- us2k10--------
    rs1388715421,2
    --20510721(+) ACACAA/CGGTGA 1 -- us2k10--------
    rs1817765511,2
    --20510751(+) AAAGGA/CTTGTA 1 -- us2k10--------
    rs121412571,2
    C,F--20510752(+) AAGGAT/CTGTAT 1 -- us2k17Minor allele frequency- C:0.38WA NA EA 366
    rs121412581,2
    C,F,A--20510755(+) GATTGT/CATAAT 1 -- us2k17Minor allele frequency- C:0.37WA NA EA 366
    rs1494142831,2
    --20510827(+) GAAGGC/GCTGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBXN10 (20512578 - 20522541 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for UBXN10: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBXN10
    DNA2.0 Custom Variant and Variant Library Synthesis for UBXN10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for UBXN10:    About MalaCards
    retinitis


    UBXN10 for disorders           About GeneDecksing


    Export disorders for UBXN10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBXN10 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with UBXN10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    6. UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. (PubMed id 18775313)1 Alexandru G....Deshaies R.J. (Cell 2008)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 127733 HGNC: 26354 AceView: UBXD3 Ensembl:ENSG00000162543 euGenes: HUgn127733
    ECgene: UBXN10 H-InvDB: UBXN10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UBXN10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBXN10 gene:
    Search GeneIP for patents involving UBXN10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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