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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UBXN10 Gene

protein-coding GIFtS: 39
GCID: GC01P020512

UBX domain protein 10

(Previous name: UBX domain containing 3 )
(Previous symbol: UBXD3)

Search for UBXN10
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
UBX Domain Protein 10¹ ²
UBXD3¹ ² ³
UBX Domain Containing 3¹ ²
UBX Domain-Containing Protein 3² ³
FLJ25429¹
UBX Domain-Containing Protein 10²

External Ids:	HGNC: 26354¹	Entrez Gene: 127733²	Ensembl: ENSG00000162543⁷	UniProtKB: Q96LJ8³

Export aliases for UBXN10 gene to outside databases

Previous GC identifers: GC01P020387 GC01P018758

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UBXN10 gene promoter:
Egr-3 AML1a Nkx2-2 MEF-2 E47 C/EBPalpha CHOP-10 MEF-2A HEN1 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBXN10 promoter sequence

Search SABiosciences Chromatin IP Primers for UBXN10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBXN10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36.13

UBXN10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBXN10 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P020512: view genomic region (about GC identifiers)

Start:	20,512,578 bp from pter	End:	20,522,541 bp from pter
Size:	9,964 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UBX10_HUMAN, Q96LJ8 (See protein sequence)

Recommended Name: UBX domain-containing protein 10

Size: 280 amino acids; 30811 Da

Secondary accessions: Q5R386

Explore the universe of human proteins at neXtProt for UBXN10: NX_Q96LJ8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96LJ8

UBXN10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689589.1

ENSEMBL proteins:

ENSP00000364240

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UBXN10 for domains About GeneDecksing

1 InterPro domain/family:

IPR001012 UBX

Graphical View of Domain Structure for InterPro Entry Q96LJ8

ProtoNet protein and cluster: Q96LJ8

1 Blocks protein family: IPB001012 UBX domain

UniProtKB/Swiss-Prot: UBX10_HUMAN, Q96LJ8

Similarity: Contains 1 UBX domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for UBXN10

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for UBXN10 (Q96LJ8³ ENSP00000364240⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UFD1L	Q92890³, ENSP00000263202⁴	I2D: score=2 STRING: ENSP00000263202
VCP	P55072³, ENSP00000351777⁴	I2D: score=2 STRING: ENSP00000351777
NPLOC4	Q8TAT6³, ENSP00000331487⁴	I2D: score=2 STRING: ENSP00000331487

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UBXN10
Search CenterWatch for drugs/clinical trials and news about UBXN10 / UBX10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UBXN10 gene:

NM_152376.3

Unigene Cluster for UBXN10:

UBX domain protein 10

Hs.432503 [show with all ESTs]

Unigene Representative Sequence: BX648631

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000375099(uc001bdb.3)

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		SwitchGear 3'UTR luciferase reporter plasmid: UBXN10 3' UTR sequence

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Additional cDNA sequence:

AK025931.1 AK058158.1 BC036417.1 BC047428.1 BX648631.1

1 DOTS entry:

DT.100010169

24/62 AceView cDNA sequences (see all 62):

BX648631 BQ689999 AI261811 AK058158 AI733818 AI344623 AA234366 AI635003

AI245236 AI968729 BM828646 BX091133 BP369047 AW269931 BQ045479 AK025931

AA394141 AA644012 BG721631 AI923876 CA311417 AA417384 NM_152376 BP370417

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UBXN10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

UBXN10 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Endochondral Facial Bones

Bone

Bone

Bone

Bone

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

See UBXN10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBXN10

SOURCE GeneReport for Unigene cluster: Hs.432503

SABiosciences Custom PCR Arrays for UBXN10

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for UBXN10 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Ubxn10^{1 , 5}	UBX domain protein 10^{1, 5}	74.55(n)¹ 70.18(a)¹	4 (70.53 cM)⁵ 212190¹ NM_178671.4¹ NP_848786.1¹ 138709837⁵
chicken (Gallus gallus)	Aves	UBXN10¹	UBX domain protein 10	58.27(n) 51.16(a)	771670 XM_001234920.2 XP_001234921.2
zebrafish (Danio rerio)	Actinopterygii	ubxn10¹	UBX domain protein 10	51.33(n) 41.5(a)	751736 NM_001045446.1 NP_001038911.1

ENSEMBL Gene Tree for UBXN10 (if available)
TreeFam Gene Tree for UBXN10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146906005^1,2		--	20510679(+)	`GCGTGC/GGTGCG`	1	--	us2k¹		0	--	--	--	--
rs12409350^1,2	C,F,H,	--	20510681(+)	`GTGCGT/CGCGCA`	1	--	us2k¹		8		WA NA CSA EA	371
rs5772887^1,2	C,	--	20510690(+)	`acacg-/CACA cacac`	1	--	us2k¹		0	--	--	--	--
rs189758628^1,2		--	20510718(+)	`CACACA/TCACGG`	1	--	us2k¹		0	--	--	--	--
rs138871542^1,2		--	20510721(+)	`ACACAA/CGGTGA`	1	--	us2k¹		0	--	--	--	--
rs181776551^1,2		--	20510751(+)	`AAAGGA/CTTGTA`	1	--	us2k¹		0	--	--	--	--
rs12141257^1,2	C,F,	--	20510752(+)	`AAGGAT/CTGTAT`	1	--	us2k¹		7		WA NA EA	366
rs12141258^1,2	C,F,A,	--	20510755(+)	`GATTGT/CATAAT`	1	--	us2k¹		7		WA NA EA	366
rs149414283^1,2		--	20510827(+)	`GAAGGC/GCTGAA`	1	--	us2k¹		0	--	--	--	--
rs186362249^1,2		--	20510880(+)	`TAAGCC/TGTCAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for UBXN10 (20512578 - 20522541 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBXN10: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for UBXN10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with UBXN10)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. (PubMed id 18775313)¹ Alexandru G....Deshaies R.J. (2008)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 127733	HGNC: 26354	AceView: UBXD3	Ensembl:ENSG00000162543	euGenes: HUgn127733
ECgene: UBXN10	H-InvDB: UBXN10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for UBXN10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UBXN10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for UBXN10 gene:
Search GeneIP for patents involving UBXN10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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UBXN10 Gene

UBX domain protein 10

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UBXN10 Gene

UBX domain protein 10

Aliasesfor UBXN10 gene

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for UBXN10 gene

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for UBXN10 gene

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for UBXN10 gene

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for UBXN10 gene

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for UBXN10 gene

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Expression
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