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Aliases for UBXN1 Gene

Aliases for UBXN1 Gene

  • UBX Domain Protein 1 2 3 5
  • SAPK Substrate Protein 1 2 3 4
  • UBA/UBX 33.3 KDa Protein 3 4
  • SAKS1 3 4
  • UBXD10 3
  • 2B28 3

External Ids for UBXN1 Gene

Previous GeneCards Identifiers for UBXN1 Gene

  • GC11M062201
  • GC11M062444
  • GC11M058772
  • GC11M062447
  • GC11M062462
  • GC11M062471
  • GC11M062477
  • GC11M062489
  • GC11M062681
  • GC11M062706

Summaries for UBXN1 Gene

GeneCards Summary for UBXN1 Gene

UBXN1 (UBX Domain Protein 1) is a Protein Coding gene. GO annotations related to this gene include ubiquitin protein ligase binding and ATPase binding. An important paralog of this gene is UBXN4.

UniProtKB/Swiss-Prot for UBXN1 Gene

  • Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds Lys-6-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN1 Gene

Genomics for UBXN1 Gene

Regulatory Elements for UBXN1 Gene

Enhancers for UBXN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBXN1 on UCSC Golden Path with GeneCards custom track

Promoters for UBXN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBXN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBXN1 Gene

Chromosome:
11
Start:
62,676,498 bp from pter
End:
62,679,117 bp from pter
Size:
2,620 bases
Orientation:
Minus strand

Genomic View for UBXN1 Gene

Genes around UBXN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN1 Gene

Proteins for UBXN1 Gene

  • Protein details for UBXN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04323-UBXN1_HUMAN
    Recommended name:
    UBX domain-containing protein 1
    Protein Accession:
    Q04323
    Secondary Accessions:
    • Q9BV93
    • Q9BVV5

    Protein attributes for UBXN1 Gene

    Size:
    297 amino acids
    Molecular mass:
    33325 Da
    Quaternary structure:
    • Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Interacts with HOMER2 (By similarity). Interacts directly with VCP. Interacts with BRCA1 and BARD1; interaction takes place when BRCA1 is not autoubiquitinated but is strongly enhanced in the presence of autoubiquitinated BRCA1.

    Alternative splice isoforms for UBXN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBXN1 Gene

Proteomics data for UBXN1 Gene at MOPED

Post-translational modifications for UBXN1 Gene

  • Ubiquitination at Lys 83, Lys 105, Lys 154, Lys 178, and Lys 208
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for UBXN1 Gene

Domains & Families for UBXN1 Gene

Gene Families for UBXN1 Gene

Protein Domains for UBXN1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q04323

UniProtKB/Swiss-Prot:

UBXN1_HUMAN :
  • The UBA domain specifically recognizes and binds Lys-6-linked polyubiquitin chains.
Domain:
  • The UBA domain specifically recognizes and binds Lys-6-linked polyubiquitin chains.
  • Contains 1 UBA domain.
  • Contains 1 UBX domain.
genes like me logo Genes that share domains with UBXN1: view

Function for UBXN1 Gene

Molecular function for UBXN1 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds Lys-6-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.

Gene Ontology (GO) - Molecular Function for UBXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031593 polyubiquitin binding IDA 15362974
GO:0071796 K6-linked polyubiquitin binding IDA 20351172
genes like me logo Genes that share ontologies with UBXN1: view
genes like me logo Genes that share phenotypes with UBXN1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBXN1 Gene

Localization for UBXN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBXN1 Gene COMPARTMENTS Subcellular localization image for UBXN1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
nucleus 4

Gene Ontology (GO) - Cellular Components for UBXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with UBXN1: view

Pathways & Interactions for UBXN1 Gene

SuperPathways for UBXN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903094 negative regulation of protein K48-linked deubiquitination IDA 21135095
GO:2000157 negative regulation of ubiquitin-specific protease activity IDA 21135095
genes like me logo Genes that share ontologies with UBXN1: view

No data available for Pathways by source and SIGNOR curated interactions for UBXN1 Gene

Drugs & Compounds for UBXN1 Gene

No Compound Related Data Available

Transcripts for UBXN1 Gene

Unigene Clusters for UBXN1 Gene

UBX domain protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN1 Gene

No ASD Table

Relevant External Links for UBXN1 Gene

GeneLoc Exon Structure for
UBXN1
ECgene alternative splicing isoforms for
UBXN1

Expression for UBXN1 Gene

mRNA expression in normal human tissues for UBXN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBXN1 Gene

This gene is overexpressed in Uterus (6.7), Nasal epithelium (6.6), and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBXN1 Gene



SOURCE GeneReport for Unigene cluster for UBXN1 Gene Hs.351296

genes like me logo Genes that share expression patterns with UBXN1: view

Protein tissue co-expression partners for UBXN1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBXN1 Gene

Orthologs for UBXN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBXN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBXN1 35
  • 92.12 (n)
  • 93.92 (a)
UBXN1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBXN1 35
  • 90.2 (n)
  • 93.24 (a)
UBXN1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubxn1 35
  • 88.66 (n)
  • 92.93 (a)
Ubxn1 16
Ubxn1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBXN1 35
  • 99.66 (n)
  • 99.66 (a)
UBXN1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubxn1 35
  • 89.11 (n)
  • 91.58 (a)
oppossum
(Monodelphis domestica)
Mammalia UBXN1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBXN1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBXN1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4804 35
ubxn1 35
  • 62.54 (n)
  • 66.08 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1496 35
zebrafish
(Danio rerio)
Actinopterygii ubxn1 35
  • 59.44 (n)
  • 54.9 (a)
ubxn1 36
  • 50 (a)
OneToMany
ubxn1 36
  • 50 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009841 35
  • 49.05 (n)
  • 42.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8209 35
  • 50.85 (n)
  • 45.29 (a)
CG8209 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ubxn-1 35
ubxn-1 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBX6 38
bread mold
(Neurospora crassa)
Ascomycetes NCU08955 35
  • 43.53 (n)
  • 30.22 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC17C9.11c 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1443 36
  • 36 (a)
OneToOne
Species with no ortholog for UBXN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBXN1 Gene

ENSEMBL:
Gene Tree for UBXN1 (if available)
TreeFam:
Gene Tree for UBXN1 (if available)

Paralogs for UBXN1 Gene

Paralogs for UBXN1 Gene

genes like me logo Genes that share paralogs with UBXN1: view

Variants for UBXN1 Gene

Sequence variations from dbSNP and Humsavar for UBXN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11543359 - 62,678,549(-) CTCCC(C/T)TTGGA intron-variant, reference, missense
rs537602 -- 62,681,104(-) GCAAA(C/T)CCTGA upstream-variant-2KB
rs644616 -- 62,677,326(+) AGAGG(G/T)ATGGG intron-variant, downstream-variant-500B
rs1050329 -- 62,677,570(-) CTCTT(C/T)TCCCA reference, missense, utr-variant-3-prime
rs1050383 -- 62,676,920(-) GCTCC(A/C)CCGTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for UBXN1 Gene

Variant ID Type Subtype PubMed ID
nsv832182 CNV Gain+Loss 17160897
nsv897623 CNV Loss 21882294

Variation tolerance for UBXN1 Gene

Residual Variation Intolerance Score: 62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UBXN1 Gene

Disorders for UBXN1 Gene

Relevant External Links for UBXN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBXN1

No disorders were found for UBXN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBXN1 Gene

Publications for UBXN1 Gene

  1. The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function. (PMID: 20351172) Wu-Baer F. … Baer R. (Mol. Cell. Biol. 2010) 2 3 4 67
  2. A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems. (PMID: 15944415) Ishibashi T. … Sugiyama H. (J. Biochem. 2005) 3 23
  3. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 2 3
  4. Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor I_B (NF-I_B) signaling. (PMID: 25681446) Wang Y.B. … Li H.Y. (J. Biol. Chem. 2015) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for UBXN1 Gene

Sources for UBXN1 Gene

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