UBXN1 Gene
protein-coding GIFtS: 50
GCID: GC11M062471
|
|
UBX domain protein 1
| |
Aliases
for UBXN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| UBX Domain Protein 11 2 | | SAPK Substrate Protein 12 3 | | SAKS11 2 3 | | UBA/UBX 33.3 KDa Protein2 3 | | 2B281 2 | | LOC510351 | | UBXD101 2 | | UBX Domain-Containing Protein 12 |
Export aliases for UBXN1 gene to outside databasesPrevious GC identifers: GC11M062201 GC11M062444 GC11M058772 GC11M062447 GC11M062462 |
Summaries
for UBXN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBXN1_HUMAN, Q04323Function: Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity.Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit theE3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to coupledeglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that areretrotranslocated in the cytosol
|
Genomic Views
for UBXN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBXN1 gene promoter:
E2F-3a E2F-4 NF-1 NF-1/L E2F-5 E2F-2 RORalpha1 E2F E2F-1 ZIC2/Zic2
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBXN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBXN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.3 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q23UBXN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M062471: view genomic region
(about GC identifiers)
Start:
|
62,443,970 bp from pter |
End:
|
62,446,567 bp from pter |
Size:
|
2,598 bases |
Orientation:
|
minus strand |
|
Proteins
for UBXN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBXN1_HUMAN, Q04323 (See
protein sequence)Recommended Name: UBX domain-containing protein 1 Size: 297 amino acids; 33325 Da
Subunit: Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed ofNGLY1, SAKS1, AMFR, VCP and RAD23B. Interacts with HOMER2 (By similarity). Interacts directly with VCP. Interacts withBRCA1 and BARD1; interaction takes place when BRCA1 is not autoubiquitinated but is strongly enhanced in the presenceof autoubiquitinated BRCA1
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q9BV93 Q9BVV5Alternative splicing: 2 isoforms: Q04323-1 Q04323-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UBXN1: NX_Q04323
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q04323
UBXN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056937.2
ENSEMBL proteins: ENSP00000294119 ENSP00000303991 ENSP00000432189 ENSP00000435964 ENSP00000435625
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
UBXN1 for ontologies About GeneDecksing
UBXN1 Antibody Products:
Assay Products for UBXN1: |
Protein
Domains /
Families
for UBXN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBXN1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q04323ProtoNet protein and cluster: Q04323 1 Blocks protein family: IPB001012 UBX domain
UniProtKB/Swiss-Prot: UBXN1_HUMAN, Q04323Domain: The UBA domain specifically recognizes and binds 'Lys-6'-linked polyubiquitin chainsSimilarity: Contains 1 UBA domainSimilarity: Contains 1 UBX domain |
Function
for UBXN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBXN1_HUMAN, Q04323Function: Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity.Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit theE3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to coupledeglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that areretrotranslocated in the cytosol
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
UBXN1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for UBXN1:
|
Pathways & Interactions
for UBXN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBXN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/65 Interacting proteins for UBXN1 (Q043233 ENSP000002941194) via UniProtKB, MINT, STRING, and/or I2D (see all 65)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031397 | negative regulation of protein ubiquitination |
IDA | -- | | GO:0032268 | regulation of cellular protein metabolic process |
-- | -- | | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
IDA | -- | | GO:0043161 | proteasomal ubiquitin-dependent protein catabolic process |
NAS | 15362974 |
UBXN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBXN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBXN1
Search CenterWatch for drugs/clinical trials and news about UBXN1
|
Transcripts
for UBXN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBXN1 gene: NM_015853.3 Unigene Cluster for UBXN1: UBX domain protein 1 Hs.351296 [show with all ESTs]Unigene Representative Sequence: BC03268917 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000294119(uc001nuj.3) ENST00000532904(uc001nuk.3) ENST00000301935(uc001nul.2)
ENST00000533000 ENST00000533476(uc010rme.1) ENST00000529640 ENST00000525717
ENST00000534176 ENST00000525004 ENST00000524762 ENST00000527421 ENST00000526919
ENST00000533908 ENST00000528907(uc010rmf.2) ENST00000531056 ENST00000436354
ENST00000531625
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBXN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBXN1 (NM_015853) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBXN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBXN1 |
Additional cDNA sequence: AK054832.1 AK297856.1 AK300542.1 AK303471.1 AK316012.1 BC000902.2 BC001372.2 BC032689.1 BC040129.1 M68864.1 15 DOTS entries: DT.92451841 DT.97857059 DT.100883758 DT.317656 DT.95372095 DT.120701319 DT.100883768 DT.120701309 DT.100883762 DT.100837972 DT.100883755 DT.120701294 DT.91642459 DT.100883728 DT.95372086 24/521 AceView cDNA sequences (see all 521): BQ072103 NM_015853 BM042380 BM670990 CD368876 CN485206 BC000902 CA453986 BM909457 BM781903 CR593998 BG741404 BM664206 AI347485 CR603968 BQ894507 BX358073 BF593610 BQ950014 BQ278917 BU845921 BC032689 AJ572746 CD106939
GeneLoc Exon Structure
|
Expression
for UBXN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBXN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCGGCCTC
About this image
See UBXN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBXN1
SOURCE GeneReport for Unigene cluster: Hs.351296
SABiosciences Custom PCR Arrays for UBXN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBXN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBXN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBXN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBXN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN1 |
Orthologs
for UBXN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBXN1 gene from 7/29 species (see all 29) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
UBXN16 |
-- |
67(a) |
1 ↔ 1 |
GL344296.1(1256-10576) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.14962 |
Xenopus laevis transcribed sequence with weak similarity more |
72.11(n) |
|
BU907420.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CA975614.12 |
-- |
73.31(n) |
|
CA975614.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG82091 |
CG8209 |
49.75(n)
43.28(a) |
|
38888 NM_139910.3 NP_648167.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
ubxn-11 |
Protein UBXN-1 |
43.69(n)
33.71(a) |
|
171804 NM_058577.3 NP_490978.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G486906AT1G048506 |
uncharacterized proteinubiquitin-associated (UBA)/TS-N domain-containing ... |
21(a)20(a) |
many ↔ manymany ↔ many |
5(19747026-19749061) 1(1365118-1368844) |
rice
(Oryza sativa) |
Liliopsida |
---- |
ZOS2-07 - C2H2 zinc finger protein, expressed |
21(a)21(a) |
many ↔ manymany ↔ many |
8(26211688-26216530) 2(17924817-17930547) |
ENSEMBL Gene Tree for UBXN1 (if available)
TreeFam Gene Tree for UBXN1 (if available) |
Paralogs
for UBXN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBXN1 gene
- UBXN42
UBXN1 for paralogs About GeneDecksing
|
Genomic Variants
for UBXN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBXN1 (62443970 - 62446567 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UBXN1
1 CNV: 4749 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBXN1 |
|
Disorders
/ Diseases
for UBXN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBXN1 for disorders About GeneDecksing
1  disease for UBXN1: About MalaCardsmalaria
Export disorders for UBXN1 gene to outside databases
|
Publications
for UBXN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBXN1 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with UBXN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The UBXN1 protein associates with autoubiquitinated f orms of the BRCA1 tumor suppressor and inhibits its enzymatic function. (PubMed id 20351172)1, 2, 3 Wu-Baer F....Baer R. (2010)
- UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. (PubMed id 18775313)1, 2 Alexandru G....Deshaies R.J. (2008)
- A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. (PubMed id 15362974)1, 2 McNeill H.... Cohen P. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems. (PubMed id 15944415)1, 9 Ishibashi T....Sugiyama H. (2005)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
|
External Searches for UBXN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBXN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBXN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBXN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBXN1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBXN1 gene:
Search GeneIP for patents involving UBXN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBXN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 |
 |
 | | | UBXN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBXN1 |
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