Aliases for UBXN1 Gene
External Ids for UBXN1 Gene
Previous GeneCards Identifiers for UBXN1 Gene
GeneCards Summary for UBXN1 Gene
UBXN1 (UBX Domain Protein 1) is a Protein Coding gene. GO annotations related to this gene include ubiquitin protein ligase binding and ATPase binding. An important paralog of this gene is UBXN4.
UniProtKB/Swiss-Prot for UBXN1 Gene
Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds Lys-6-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.