Aliases for UBXN1 Gene
External Ids for UBXN1 Gene
Previous GeneCards Identifiers for UBXN1 Gene
GeneCards Summary for UBXN1 Gene
UBXN1 (UBX Domain Protein 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. GO annotations related to this gene include ubiquitin protein ligase binding and ATPase binding. An important paralog of this gene is UBXN4.
UniProtKB/Swiss-Prot for UBXN1 Gene
Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds Lys-6-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.