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Aliases for UBXN1 Gene

Aliases for UBXN1 Gene

  • UBX Domain Protein 1 2 3 5
  • SAPK Substrate Protein 1 2 3 4
  • UBA/UBX 33.3 KDa Protein 3 4
  • SAKS1 3 4
  • UBX Domain-Containing Protein 1 3
  • UBXD10 3
  • 2B28 3

External Ids for UBXN1 Gene

Previous GeneCards Identifiers for UBXN1 Gene

  • GC11M062201
  • GC11M062444
  • GC11M058772
  • GC11M062447
  • GC11M062462
  • GC11M062471
  • GC11M062477
  • GC11M062489
  • GC11M062681
  • GC11M062706
  • GC11M062725
  • GC11M062737
  • GC11M062750
  • GC11M062769
  • GC11M062785

Summaries for UBXN1 Gene

GeneCards Summary for UBXN1 Gene

UBXN1 (UBX Domain Protein 1) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and ATPase binding. An important paralog of this gene is UBXN4.

UniProtKB/Swiss-Prot for UBXN1 Gene

  • Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling (PubMed:23545497). Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 (PubMed:25681446). Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B (PubMed:28152074). Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds Lys-6-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (PubMed:20351172). Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.

Additional gene information for UBXN1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBXN1 Gene

Genomics for UBXN1 Gene

GeneHancer (GH) Regulatory Elements for UBXN1 Gene

Promoters and enhancers for UBXN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I062676 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.7 721 3.1 HDGF SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 UBXN1 EML3 TTC9C GC11M062588
GH11I062680 Enhancer 1 Ensembl ENCODE 550.8 -2.0 -1977 1.4 CTCF SAP130 ARID4B EBF1 CEBPG RAD21 RFX5 TEAD3 ZNF335 GATAD1 UBXN1 LRRN4CL
GH11I062838 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 91.1 -161.7 -161729 4.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 WDR74 GC11M062842 RNU2-2P NXF1 CSKMT INTS5 UBXN1 MTA2 SNHG1 GANAB
GH11I062852 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 61.3 -176.7 -176720 5.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SNHG1 SLC3A2 ENSG00000278527 GC11M062911 GC11M062919 GC11M062920 GC11M062923 GC11M062925 GC11M062930 SNORD25
GH11I061960 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 55 +710.2 710193 16.4 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 FTH1 GC11M061968 GC11M061969 GC11M061970 LOC399900 NXF1 INTS5 LOC105369332 CPSF7 UBXN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBXN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBXN1 gene promoter:

Genomic Locations for UBXN1 Gene

Genomic Locations for UBXN1 Gene
chr11:62,676,498-62,679,117
(GRCh38/hg38)
Size:
2,620 bases
Orientation:
Minus strand
chr11:62,443,970-62,446,567
(GRCh37/hg19)

Genomic View for UBXN1 Gene

Genes around UBXN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBXN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBXN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBXN1 Gene

Proteins for UBXN1 Gene

  • Protein details for UBXN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04323-UBXN1_HUMAN
    Recommended name:
    UBX domain-containing protein 1
    Protein Accession:
    Q04323
    Secondary Accessions:
    • Q9BV93
    • Q9BVV5

    Protein attributes for UBXN1 Gene

    Size:
    297 amino acids
    Molecular mass:
    33325 Da
    Quaternary structure:
    • Interacts with MAVS; this interaction prevents MAVS oligomerization and thus disrupts the RLR signaling pathway (PubMed:23545497). Interacts with CUL1; this interaction inhibits CUL1-mediated degradation of NF-kappa-B inhibitors (PubMed:28152074). Interacts with BIRC2/c-IAP1; this interaction prevents TNFalpha-stimulated RIP1 ubiquitination and subsequent NF-kappa-B activation (PubMed:25681446). Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Interacts with HOMER2 (By similarity). Interacts directly with VCP. Interacts with BRCA1 and BARD1; interaction takes place when BRCA1 is not autoubiquitinated but is strongly enhanced in the presence of autoubiquitinated BRCA1.

    Alternative splice isoforms for UBXN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBXN1 Gene

Post-translational modifications for UBXN1 Gene

  • Ubiquitination at isoforms=283, posLast=105105, posLast=154154, posLast=178178, and isoforms=2208

No data available for DME Specific Peptides for UBXN1 Gene

Domains & Families for UBXN1 Gene

Gene Families for UBXN1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBXN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q04323

UniProtKB/Swiss-Prot:

UBXN1_HUMAN :
  • The UBA domain specifically recognizes and binds Lys-6-linked polyubiquitin chains.
Domain:
  • The UBA domain specifically recognizes and binds Lys-6-linked polyubiquitin chains.
genes like me logo Genes that share domains with UBXN1: view

Function for UBXN1 Gene

Molecular function for UBXN1 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling (PubMed:23545497). Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 (PubMed:25681446). Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B (PubMed:28152074). Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds Lys-6-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (PubMed:20351172). Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.

Phenotypes From GWAS Catalog for UBXN1 Gene

Gene Ontology (GO) - Molecular Function for UBXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18775313
GO:0031593 polyubiquitin modification-dependent protein binding IDA 15362974
GO:0031625 ubiquitin protein ligase binding IDA 18775313
GO:0036435 K48-linked polyubiquitin modification-dependent protein binding IDA 21135095
GO:0043130 ubiquitin binding IDA 18775313
genes like me logo Genes that share ontologies with UBXN1: view
genes like me logo Genes that share phenotypes with UBXN1: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBXN1 Gene

Localization for UBXN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBXN1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBXN1 gene
Compartment Confidence
cytosol 5
nucleus 4
endoplasmic reticulum 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UBXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 colocalizes_with proteasome complex IDA 15362974
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA,IEA 10942595
GO:0005783 endoplasmic reticulum IDA 21135095
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with UBXN1: view

Pathways & Interactions for UBXN1 Gene

genes like me logo Genes that share pathways with UBXN1: view

Gene Ontology (GO) - Biological Process for UBXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0031397 negative regulation of protein ubiquitination IDA 20351172
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA 20351172
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process NAS 15362974
GO:1903094 negative regulation of protein K48-linked deubiquitination IDA 21135095
genes like me logo Genes that share ontologies with UBXN1: view

No data available for SIGNOR curated interactions for UBXN1 Gene

Drugs & Compounds for UBXN1 Gene

No Compound Related Data Available

Transcripts for UBXN1 Gene

Unigene Clusters for UBXN1 Gene

UBX domain protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBXN1 Gene

No ASD Table

Relevant External Links for UBXN1 Gene

GeneLoc Exon Structure for
UBXN1
ECgene alternative splicing isoforms for
UBXN1

Expression for UBXN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBXN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBXN1 Gene

This gene is overexpressed in Uterus (6.7), Nasal epithelium (6.6), and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBXN1 Gene



Protein tissue co-expression partners for UBXN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBXN1 Gene:

UBXN1

SOURCE GeneReport for Unigene cluster for UBXN1 Gene:

Hs.351296

Evidence on tissue expression from TISSUES for UBXN1 Gene

  • Skin(4.5)
  • Liver(4.4)
  • Intestine(4.3)
  • Nervous system(3.5)
  • Lung(3)
  • Eye(2.4)
genes like me logo Genes that share expression patterns with UBXN1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBXN1 Gene

Orthologs for UBXN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBXN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBXN1 34 33
  • 99.66 (n)
OneToOne
cow
(Bos Taurus)
Mammalia UBXN1 33 34
  • 92.12 (n)
dog
(Canis familiaris)
Mammalia UBXN1 33 34
  • 90.2 (n)
rat
(Rattus norvegicus)
Mammalia Ubxn1 33
  • 89.11 (n)
mouse
(Mus musculus)
Mammalia Ubxn1 33 16 34
  • 88.66 (n)
oppossum
(Monodelphis domestica)
Mammalia UBXN1 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBXN1 34
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBXN1 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubxn1 33
  • 62.54 (n)
Str.4804 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1496 33
zebrafish
(Danio rerio)
Actinopterygii ubxn1 33 34 34
  • 59.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8209 33 34
  • 50.85 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009841 33
  • 49.05 (n)
worm
(Caenorhabditis elegans)
Secernentea ubxn-1 33 34
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBX6 36
bread mold
(Neurospora crassa)
Ascomycetes NCU08955 33
  • 43.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1443 34
  • 36 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC17C9.11c 33
Species where no ortholog for UBXN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBXN1 Gene

ENSEMBL:
Gene Tree for UBXN1 (if available)
TreeFam:
Gene Tree for UBXN1 (if available)

Paralogs for UBXN1 Gene

Paralogs for UBXN1 Gene

genes like me logo Genes that share paralogs with UBXN1: view

Variants for UBXN1 Gene

Sequence variations from dbSNP and Humsavar for UBXN1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000431842 -- 62,678,813(-) A/G intron_variant
rs1002618667 -- 62,679,624(-) C/T upstream_transcript_variant
rs1002630132 -- 62,679,337(-) T/C upstream_transcript_variant
rs1002649502 -- 62,677,096(-) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1003600648 -- 62,681,101(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for UBXN1 Gene

Variant ID Type Subtype PubMed ID
nsv555174 CNV gain 21841781
nsv832182 CNV gain+loss 17160897

Variation tolerance for UBXN1 Gene

Residual Variation Intolerance Score: 62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBXN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBXN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBXN1 Gene

Disorders for UBXN1 Gene

Additional Disease Information for UBXN1

No disorders were found for UBXN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBXN1 Gene

Publications for UBXN1 Gene

  1. The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function. (PMID: 20351172) Wu-Baer F … Baer R (Molecular and cellular biology 2010) 2 3 4 58
  2. Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα. (PMID: 28152074) Hu Y … Sutton RE (PLoS pathogens 2017) 3 4 58
  3. Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor κB (NF-κB) signaling. (PMID: 25681446) Wang YB … Li HY (The Journal of biological chemistry 2015) 3 4 58
  4. UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS. (PMID: 23545497) Wang P … Sutton RE (Cell reports 2013) 3 4 58
  5. UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. (PMID: 18775313) Alexandru G … Deshaies RJ (Cell 2008) 3 4 58

Products for UBXN1 Gene

Sources for UBXN1 Gene

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