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Aliases for UBTFL1 Gene

Aliases for UBTFL1 Gene

  • Upstream Binding Transcription Factor, RNA Polymerase I-Like 1 2 3
  • C11orf27 3 4
  • HMGPI 3 6
  • Putative Upstream-Binding Factor 1-Like Protein 1 3
  • Upstream-Binding Factor 1-Like Protein 1 3
  • Chromosome 11 Open Reading Frame 27 2

External Ids for UBTFL1 Gene

Previous HGNC Symbols for UBTFL1 Gene

  • C11orf27

Previous GeneCards Identifiers for UBTFL1 Gene

  • GC11P089460
  • GC11P089819

Summaries for UBTFL1 Gene

Entrez Gene Summary for UBTFL1 Gene

  • UBTFL1 is a preimplantation-specific gene and is involved in early development, implantation, and embryonic stem (ES) cell derivation (summary by Yamada et al., 2010 [PubMed 19915186]).[supplied by OMIM, Jan 2011]

GeneCards Summary for UBTFL1 Gene

UBTFL1 (Upstream Binding Transcription Factor, RNA Polymerase I-Like 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for UBTFL1 Gene

  • Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBTFL1 Gene

Genomics for UBTFL1 Gene

Regulatory Elements for UBTFL1 Gene

Genomic Location for UBTFL1 Gene

Start:
90,085,950 bp from pter
End:
90,087,131 bp from pter
Size:
1,182 bases
Orientation:
Plus strand

Genomic View for UBTFL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBTFL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBTFL1 Gene

Proteins for UBTFL1 Gene

  • Protein details for UBTFL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CB47-UBFL1_HUMAN
    Recommended name:
    Putative upstream-binding factor 1-like protein 1
    Protein Accession:
    P0CB47
    Secondary Accessions:
    • C9JMX8

    Protein attributes for UBTFL1 Gene

    Size:
    393 amino acids
    Molecular mass:
    46134 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UBTFL1 Gene

Proteomics data for UBTFL1 Gene at MOPED

Post-translational modifications for UBTFL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBTFL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBTFL1 Gene

Domains for UBTFL1 Gene

Protein Domains for UBTFL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for UBTFL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CB47

UniProtKB/Swiss-Prot:

UBFL1_HUMAN :
  • P0CB47
Domain:
  • Contains 2 HMG box DNA-binding domains.
genes like me logo Genes that share domains with UBTFL1: view

No data available for Gene Families for UBTFL1 Gene

Function for UBTFL1 Gene

Molecular function for UBTFL1 Gene

UniProtKB/Swiss-Prot Function: Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development.

Gene Ontology (GO) - Molecular Function for UBTFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with UBTFL1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UBTFL1 Gene

Localization for UBTFL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBTFL1 Gene

Cytoplasm. Nucleus. Note=Mainly cytoplasmic from the 4-cell stage to the morula stage. Becomes nuclear at the blastocyst stage (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBTFL1 Gene COMPARTMENTS Subcellular localization image for UBTFL1 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for UBTFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBTFL1: view

Pathways for UBTFL1 Gene

SuperPathways for UBTFL1 Gene

No Data Available

Interacting Proteins for UBTFL1 Gene

Gene Ontology (GO) - Biological Process for UBTFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001832 blastocyst growth IEA --
GO:0007275 multicellular organismal development --
GO:0007566 embryo implantation IEA --
GO:0010468 regulation of gene expression IEA --
genes like me logo Genes that share ontologies with UBTFL1: view

No data available for Pathways by source for UBTFL1 Gene

Transcripts for UBTFL1 Gene

mRNA/cDNA for UBTFL1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBTFL1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for UBTFL1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBTFL1 Gene

No ASD Table

Relevant External Links for UBTFL1 Gene

GeneLoc Exon Structure for
UBTFL1
ECgene alternative splicing isoforms for
UBTFL1

Expression for UBTFL1 Gene

mRNA expression in normal human tissues for UBTFL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for UBTFL1 Gene

SOURCE GeneReport for Unigene cluster for UBTFL1 Gene Hs.719885

genes like me logo Genes that share expressions with UBTFL1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBTFL1 Gene

Orthologs for UBTFL1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for UBTFL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBTFL1 35
  • 97.63 (n)
  • 94.15 (a)
Species with no ortholog for UBTFL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UBTFL1 Gene

ENSEMBL:
Gene Tree for UBTFL1 (if available)
TreeFam:
Gene Tree for UBTFL1 (if available)

Paralogs for UBTFL1 Gene

Selected SIMAP similar genes for UBTFL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBTFL1: view

No data available for Paralogs for UBTFL1 Gene

Variants for UBTFL1 Gene

Sequence variations from dbSNP and Humsavar for UBTFL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1784282 -- 90,084,829(+) TGATG(A/G)ACAAT upstream-variant-2KB
rs2212476 -- 90,084,440(+) CACCA(A/G)TATCT upstream-variant-2KB
rs2212477 -- 90,084,565(+) ACACA(A/G)TTTTA upstream-variant-2KB
rs2508910 -- 90,084,691(+) AGACA(A/G)AATTG upstream-variant-2KB
rs2846255 -- 90,084,487(+) CCCCT(C/G)AAGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UBTFL1 Gene

Variant ID Type Subtype PubMed ID
nsv898094 CNV Gain 21882294
dgv412e1 CNV Complex 17122850
nsv898118 CNV Gain 21882294
nsv898138 CNV Gain 21882294
nsv898139 CNV Loss 21882294
nsv8859 CNV Loss 18304495

Relevant External Links for UBTFL1 Gene

HapMap Linkage Disequilibrium report
UBTFL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBTFL1 Gene

Disorders for UBTFL1 Gene

No disorders were found for UBTFL1 Gene.

No data available for UniProtKB/Swiss-Prot for UBTFL1 Gene

Publications for UBTFL1 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4
  2. Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development. (PMID: 19915186) Yamada M. … Umezawa A. (Hum. Mol. Genet. 2010) 2 3

Products for UBTFL1 Gene

Sources for UBTFL1 Gene

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