Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBTF Gene

Aliases for UBTF Gene

  • Upstream Binding Transcription Factor, RNA Polymerase I 2 3
  • UBF 3 4 6
  • Autoantigen NOR-90 3 4
  • UBF-1 3 4
  • UBF1 3 4
  • 90-KDa Nucleolus Organizer Region Autoantigen 3
  • Nucleolar Transcription Factor 1 3
  • Upstream-Binding Factor 1 4
  • NOR-90 3
  • UBF2 3

External Ids for UBTF Gene

Previous GeneCards Identifiers for UBTF Gene

  • GC17M042025
  • GC17M044461
  • GC17M042294
  • GC17M042757
  • GC17M042759
  • GC17M039637
  • GC17M038046
  • GC17M042282

Summaries for UBTF Gene

Entrez Gene Summary for UBTF Gene

  • This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]

GeneCards Summary for UBTF Gene

UBTF (Upstream Binding Transcription Factor, RNA Polymerase I) is a Protein Coding gene. Among its related pathways are ERK Signaling and Gene Expression.

UniProtKB/Swiss-Prot for UBTF Gene

  • Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.

Gene Wiki entry for UBTF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBTF Gene

Genomics for UBTF Gene

Regulatory Elements for UBTF Gene

Transcription factor binding sites by QIAGEN in the UBTF gene promoter:

Genomic Location for UBTF Gene

Start:
44,205,033 bp from pter
End:
44,221,626 bp from pter
Size:
16,594 bases
Orientation:
Minus strand

Genomic View for UBTF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBTF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBTF Gene

Proteins for UBTF Gene

  • Protein details for UBTF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17480-UBF1_HUMAN
    Recommended name:
    Nucleolar transcription factor 1
    Protein Accession:
    P17480
    Secondary Accessions:
    • A8K6R8

    Protein attributes for UBTF Gene

    Size:
    764 amino acids
    Molecular mass:
    89406 Da
    Quaternary structure:
    • Homodimer. Interacts with TBP. Interacts with RASL11A, TAF1A and TAF1D. Binds to IRS1 and PIK3CA (By similarity). Interacts with DHX33. Interacts with PHF6. Interacts with CEBPA (isoform 1 and isoform 4) (PubMed:20075868).

    Three dimensional structures from OCA and Proteopedia for UBTF Gene

    Alternative splice isoforms for UBTF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBTF Gene

Proteomics data for UBTF Gene at MOPED

Post-translational modifications for UBTF Gene

  • Phosphorylated and activated by PIK3CA.
  • Ubiquitination at Lys45, Lys71, Lys132, Lys266, Lys279, Lys333, and Lys216
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UBTF Gene

Domains for UBTF Gene

Protein Domains for UBTF Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P17480

UniProtKB/Swiss-Prot:

UBF1_HUMAN :
  • P17480
Domain:
  • Contains 6 HMG box DNA-binding domains.
genes like me logo Genes that share domains with UBTF: view

No data available for Gene Families for UBTF Gene

Function for UBTF Gene

Molecular function for UBTF Gene

GENATLAS Biochemistry: RNA polymerase 1,associated transcription factor 1,hUBF-NORGO essential for activation of transcription of 18S and 28S RNA
UniProtKB/Swiss-Prot Function: Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.

Gene Ontology (GO) - Molecular Function for UBTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA --
GO:0005488 binding --
GO:0005515 protein binding IPI 16777843
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with UBTF: view

Phenotypes for UBTF Gene

GenomeRNAi human phenotypes for UBTF:
genes like me logo Genes that share phenotypes with UBTF: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBTF Gene

Localization for UBTF Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBTF Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBTF Gene COMPARTMENTS Subcellular localization image for UBTF gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for UBTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus ISS --
genes like me logo Genes that share ontologies with UBTF: view

Pathways for UBTF Gene

genes like me logo Genes that share pathways with UBTF: view

Gene Ontology (GO) - Biological Process for UBTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IBA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006356 regulation of transcription from RNA polymerase I promoter TAS 2330041
GO:0006360 transcription from RNA polymerase I promoter TAS --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
genes like me logo Genes that share ontologies with UBTF: view

Compounds for UBTF Gene

(10) Novoseek inferred chemical compound relationships for UBTF Gene

Compound -log(P) Hits PubMed IDs
rrna 68.2 20
actinomycin 57.9 1
emetine 52.7 3
actinomycin d 42.3 5
cisplatin 24.6 6
genes like me logo Genes that share compounds with UBTF: view

Transcripts for UBTF Gene

Unigene Clusters for UBTF Gene

Upstream binding transcription factor, RNA polymerase I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBTF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7: - - - -
SP8: -
SP9: -

ExUns: 23 ^ 24 ^ 25a · 25b ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for UBTF Gene

GeneLoc Exon Structure for
UBTF
ECgene alternative splicing isoforms for
UBTF

Expression for UBTF Gene

mRNA expression in normal human tissues for UBTF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBTF Gene

SOURCE GeneReport for Unigene cluster for UBTF Gene Hs.89781

genes like me logo Genes that share expressions with UBTF: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBTF Gene

Orthologs for UBTF Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBTF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBTF 35
  • 97.28 (n)
  • 96.74 (a)
UBTF 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBF 36
  • 97 (a)
OneToOne
UBTF 35
  • 94.08 (n)
  • 97.91 (a)
dog
(Canis familiaris)
Mammalia UBTF 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubtf 35
  • 91.97 (n)
  • 99.26 (a)
Ubtf 16
Ubtf 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBTF 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubtf 35
  • 90.49 (n)
  • 98.3 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 89 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
UBTF 35
  • 88.46 (n)
  • 96.59 (a)
lizard
(Anolis carolinensis)
Reptilia UBTF 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52607 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10891 35
ubtf 35
  • 73.62 (n)
  • 78.66 (a)
zebrafish
(Danio rerio)
Actinopterygii ubtf 35
  • 69.86 (n)
  • 69.41 (a)
ubtf 36
  • 66 (a)
OneToOne
zgc63557 35
Species with no ortholog for UBTF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBTF Gene

ENSEMBL:
Gene Tree for UBTF (if available)
TreeFam:
Gene Tree for UBTF (if available)

Paralogs for UBTF Gene

Selected SIMAP similar genes for UBTF Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with UBTF: view

No data available for Paralogs for UBTF Gene

Variants for UBTF Gene

Structural Variations from Database of Genomic Variants (DGV) for UBTF Gene

Variant ID Type Subtype PubMed ID
nsv833455 CNV Loss 17160897
nsv908269 CNV Loss 21882294
nsv908270 CNV Loss 21882294
nsv908271 CNV Loss 21882294
dgv529n67 CNV Gain 20364138
nsv908272 CNV Loss 21882294
nsv510713 CNV Loss 20534489
dgv3174n71 CNV Loss 21882294
esv29087 CNV Loss 19812545

Relevant External Links for UBTF Gene

HapMap Linkage Disequilibrium report
UBTF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for UBTF Gene

Disorders for UBTF Gene

(1) University of Copenhagen DISEASES for UBTF Gene

(5) Novoseek inferred disease relationships for UBTF Gene

Disease -log(P) Hits PubMed IDs
cardiac hypertrophy 39.5 3
hypertrophy 26.6 12
retinoblastoma 26 1
necrosis 0 3
tumors 0 3
genes like me logo Genes that share disorders with UBTF: view

No data available for UniProtKB/Swiss-Prot for UBTF Gene

Publications for UBTF Gene

  1. Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins. (PMID: 2330041) Jantzen H.M. … Tjian R. (Nature 1990) 3 4 23
  2. Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping. (PMID: 9126496) Matera A.G. … Chan E.K. (Genomics 1997) 2 3 23
  3. The RNA polymerase I transcription factor, upstream binding factor, interacts directly with the TATA box-binding protein. (PMID: 7982918) Kwon H. … Green M.R. (J. Biol. Chem. 1994) 4 23
  4. Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF. (PMID: 10202152) Voit R. … Grummt I. (EMBO J. 1999) 3 23
  5. Coactivator and promoter-selective properties of RNA polymerase I TAFs. (PMID: 7491500) Beckmann H. … Tjian R. (Science 1995) 4 23

Products for UBTF Gene

Sources for UBTF Gene

Back to Top

Content