Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBTF Gene

protein-coding   GIFtS: 59
GCID: GC17M042282

Upstream Binding Transcription Factor, RNA Polymerase I

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Upstream Binding Transcription Factor, RNA Polymerase I1 2     90-KDa Nucleolus Organizer Region Autoantigen2
UBF2 3 5     NOR-902
Autoantigen NOR-902 3     Nucleolar Transcription Factor 12
UBF-12 3     Upstream-Binding Factor 13
UBF12 3     

External Ids:    HGNC: 125111   Entrez Gene: 73432   Ensembl: ENSG000001083127   OMIM: 6006735   UniProtKB: P174803   
ORGUL members:         
NONCODE14:n411750      

Export aliases for UBTF gene to outside databases

Previous GC identifers: GC17M042025 GC17M044461 GC17M042294 GC17M042757 GC17M042759 GC17M039637 GC17M038046


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBTF Gene:
This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in
ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA
polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling
and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively
spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene
are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. (provided by RefSeq,
Aug 2011)

GeneCards Summary for UBTF Gene: 
UBTF (upstream binding transcription factor, RNA polymerase I) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with UBTF include treacher collins syndrome, and systemic scleroderma, and among its related super-pathways are RNA Polymerase I Promoter Clearance and RNA Polymerase II Transcription. GO annotations related to this gene include protein binding and DNA binding.

UniProtKB/Swiss-Prot: UBF1_HUMAN, P17480
Function: Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I
through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the
upstream control element

Gene Wiki entry for UBTF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBTF gene promoter:
         TBP   Sp1   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBTF promoter sequence
   Search SABiosciences Chromatin IP Primers for UBTF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBTF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

UBTF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBTF gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M042282:  view genomic region     (about GC identifiers)

Start:
42,282,401 bp from pter      End:
42,298,994 bp from pter
Size:
16,594 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBF1_HUMAN, P17480 (See protein sequence)
Recommended Name: Nucleolar transcription factor 1  
Size: 764 amino acids; 89406 Da
Subunit: Homodimer. Interacts with TBP. Interacts with RASL11A, TAF1A and TAF1D. Binds to IRS1 and PIK3CA (By
similarity). Interacts with DHX33
Subcellular location: Nucleus, nucleolus (By similarity)
4 PDB 3D structures from and Proteopedia for UBTF:
1K99 (3D)        1L8Y (3D)        1L8Z (3D)        2HDZ (3D)    
Secondary accessions: A8K6R8
Alternative splicing: 2 isoforms:  P17480-1   P17480-2   

Explore the universe of human proteins at neXtProt for UBTF: NX_P17480

Explore proteomics data for UBTF at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated and activated by PIK3CA (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17480

  • UBTF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBTF Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001070151.1  NP_001070152.1  NP_055048.1  

    ENSEMBL proteins: 
     ENSP00000345297   ENSP00000302640   ENSP00000431539   ENSP00000437180   ENSP00000390669  
     ENSP00000377231   ENSP00000432925   ENSP00000435708   ENSP00000433625   ENSP00000431295  
     ENSP00000433046  
    Reactome Protein details: P17480
    Human Recombinant Protein Products for UBTF: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UBTF
    OriGene Protein Over-expression Lysate for UBTF
    OriGene MassSpec for UBTF 
    OriGene Custom Protein Services for UBTF
    GenScript Custom Purified and Recombinant Proteins Services for UBTF
    Novus Biologicals UBTF Protein
    Novus Biologicals UBTF Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBTF 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus ISS--
    GO:0005737cytoplasm IEA--

    UBTF for ontologies           About GeneDecksing



    UBTF Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of UBTF
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UBTF
    OriGene Custom Antibody Services for UBTF
    GenScript Custom Superior Antibodies Services for UBTF
    Novus Biologicals UBTF Antibodies
    Abcam antibodies for UBTF
    Cloud-Clone Corp. Antibodies for UBTF 
    Search ThermoFisher Antibodies for UBTF
    LSBio Antibodies in human, mouse, rat for UBTF 

    Assay Products for UBTF: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBTF
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBTF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UBTF 
    Cloud-Clone Corp. CLIAs for UBTF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009071 HMG_box_dom

    Graphical View of Domain Structure for InterPro Entry P17480

    ProtoNet protein and cluster: P17480

    UniProtKB/Swiss-Prot: UBF1_HUMAN, P17480
    Similarity: Contains 6 HMG box DNA-binding domains


    UBTF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBF1_HUMAN, P17480
    Function: Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I
    through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the
    upstream control element

         Genatlas biochemistry entry for UBTF:
    RNA polymerase 1,associated transcription factor 1,hUBF-NORGO essential for activation of transcription of 18S and
    28S RNA

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI16777843
         
    UBTF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UBTF:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBTF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBTF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBTF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBTF 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBTF
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate UBTF (see all 68):
    hsa-miR-549 hsa-miR-3678-3p hsa-miR-642a hsa-miR-4254 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-519a hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidUBTF 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UBTF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBTF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBTF
    Sirion Biotech Customized adenovirus for overexpression of UBTF

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UBTF (see all 17)
    OriGene ORF clones in mouse, rat for UBTF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): UBTF (NM_014233)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBTF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBTF
    Sirion Biotech Customized lentivirus for stable overexpression of UBTF 
                         Customized lentivirus expression plasmids for stable overexpression of UBTF 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UBTF
    Search LifeMap BioReagents cell lines for UBTF
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBTF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBTF About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Chain Elongation
    RNA Polymerase I Transcription0.92
    RNA Polymerase I Transcription Initiation0.90
    RNA Polymerase I Promoter Clearance0.92
    RNA Polymerase I Transcription Termination0.90
    RNA Polymerase I Promoter Escape0.91
    Assembly of RNA Polymerase-I Initiation Complex0.32
    RNA Polymerase I Chain Elongation0.90
    2Transcription
    Transcription0.69
    3Rho Family GTPases
    ERK Signaling0.61
    4RNA Polymerase III Transcription Initiation
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.59
    5Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBTF
        ERK Signaling
    Assembly of RNA Polymerase-I Initiation Complex

    2 BioSystems Pathways for UBTF
        Regulation of retinoblastoma protein
    Validated targets of C-MYC transcriptional activation

    5/10        Reactome Pathways for UBTF (see all 10)
        RNA Polymerase I Transcription
    RNA Polymerase I Chain Elongation
    RNA Polymerase I Promoter Opening
    Transcription
    RNA Polymerase I Promoter Clearance



    UBTF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBTF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/94 Interacting proteins for UBTF (P174801, 2, 3 ENSP000003026404) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SETQ011052, 3, ENSP000003617774MINT-4544016 MINT-4543858 MINT-4543985 MINT-4544002 I2D: score=1 STRING: ENSP00000361777
    FBLP220872, 3, ENSP000002218014MINT-1894291 MINT-8373408 I2D: score=1 STRING: ENSP00000221801
    ZMYM2Q9UBW72, 3, ENSP000003723224MINT-62331 I2D: score=3 STRING: ENSP00000372322
    MYCP011061, 3, ENSP000003672074EBI-396235,EBI-447544 I2D: score=2 STRING: ENSP00000367207
    CHGBP050602, 3MINT-63514 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001832blastocyst growth IEA--
    GO:0006356regulation of transcription from RNA polymerase I promoter TAS2330041
    GO:0006360transcription from RNA polymerase I promoter TAS--
    GO:0006361transcription initiation from RNA polymerase I promoter TAS--
    GO:0006362transcription elongation from RNA polymerase I promoter TAS--

    UBTF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UBTF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBTF (UBF1)

    10 Novoseek inferred chemical compound relationships for UBTF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rrna 68.2 25 8609157 (5), 9611224 (2), 9843972 (2), 17182730 (2) (see all 12)
    actinomycin 57.9 1 15249688 (1)
    emetine 52.7 3 16827655 (2), 15027350 (1)
    actinomycin d 42.3 8 15265990 (2), 8041627 (1), 8871827 (1), 14729462 (1)
    cisplatin 24.6 7 8645334 (2), 8679707 (2), 9611224 (1), 11874979 (1)
    silver 17.5 2 15598984 (1), 17089916 (1)
    rapamycin 2.34 6 14612424 (2), 16079186 (1)
    agarose 0 1 11874979 (1)
    serine 0 3 8593693 (1), 9843972 (1)
    norepinephrine 0 5 7713937 (4), 8710943 (1)

    Search CenterWatch for drugs/clinical trials and news about UBTF / UBF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBTF gene (3 alternative transcripts): 
    NM_001076683.1  NM_001076684.2  NM_014233.3  

    Unigene Cluster for UBTF:

    Upstream binding transcription factor, RNA polymerase I
    Hs.89781  [show with all ESTs]
    Unigene Representative Sequence: NR_045058
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343638(uc002igc.3 uc002igd.3) ENST00000302904(uc010czs.3 uc010czt.3)
    ENST00000527034 ENST00000533177 ENST00000436088 ENST00000393606 ENST00000526094(uc002ige.2)
    ENST00000529383 ENST00000529947 ENST00000531368 ENST00000529373 ENST00000529042
    ENST00000530828 ENST00000537550
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBTF
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate UBTF (see all 68):
    hsa-miR-549 hsa-miR-3678-3p hsa-miR-642a hsa-miR-4254 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-519a hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidUBTF 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UBTF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBTF
    Clone
    Products:
         
    OriGene clones in human, mouse for UBTF (see all 17)
    OriGene ORF clones in mouse, rat for UBTF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): UBTF (NM_014233)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBTF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBTF
    Sirion Biotech Customized lentivirus for stable overexpression of UBTF 
                         Customized lentivirus expression plasmids for stable overexpression of UBTF 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for UBTF
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBTF
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBTF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBTF

    Additional mRNA sequence: 

    AF289595.1 AK291733.1 AK292518.1 AK292577.1 AK296917.1 AK298008.1 AK308321.1 BC031423.1 
    BC042297.1 M61724.1 NR_045058.1 X53461.1 X56687.1 X56688.1 

    24 DOTS entries:

    DT.95269646  DT.40290288  DT.443848  DT.97794870  DT.86855132  DT.92444724  DT.120990662  DT.100028900 
    DT.95269645  DT.95269649  DT.101960888  DT.120990639  DT.40266693  DT.95269650  DT.120990536  DT.40131576 
    DT.91654659  DT.91955619  DT.100819337  DT.120990564  DT.65286767  DT.75144517  DT.91911205  DT.95269647 

    24/284 AceView cDNA sequences (see all 284):

    BU687626 AI928028 BQ018214 BG315286 CR602921 M61724 BE856492 BM684400 
    BM695079 BM981926 AI669230 AI813977 BM801037 BC042297 AA974737 BG261415 
    BM976640 BE671708 BE675252 AA453106 AA582869 AW189464 AI915777 AI685620 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for UBTF (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:              -     -     -                                               -                                   -                                         -   
    SP2:                    -     -                                               -                                   -                                         -   
    SP3:                                                                                                              -                                         -   
    SP4:                                                                                                  -           -                                             
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25a · 25b ^ 26
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for UBTF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBTF expression in normal human tissues (normalized intensities)      UBTF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGAGGGGG
    UBTF Expression
    About this image


    UBTF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See UBTF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBTF

    SOURCE GeneReport for Unigene cluster: Hs.89781
        SABiosciences Custom PCR Arrays for UBTF
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for UBTF
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBTF
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBTF
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBTF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBTF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBTF gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubtf1 , 5 upstream binding transcription factor, RNA polymerase more1, 5 91.32(n)1
    97.91(a)1
      11 (66.29 cM)5
    214291  NM_011551.51  NP_035681.21 
     1023045605 
    chicken
    (Gallus gallus)
    Aves LOC1008597921 nucleolar transcription factor 1-like 88.46(n)
    96.59(a)
      100859792  XM_003643427.1  XP_003643475.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBTF6
    Uncharacterized protein
    85(a)
    1 ↔ 1
    6(66727345-66766255)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC526072 similar to upstream binding transcription factor, RNA more 75.67(n)    X57561.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635572 similar to transcription factor UBF 77.93(n)   393978  BC055140.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G238001 HMG (high mobility group) box protein 44.22(n)
    28.82(a)
      828480  NM_118511.3  NP_194111.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g02582001 hypothetical protein 53.15(n)
    30.41(a)
      4328927  NM_001053009.1  NP_001046474.1 


    ENSEMBL Gene Tree for UBTF (if available)
    TreeFam Gene Tree for UBTF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBTF gene
    4 SIMAP similar genes for UBTF using alignment to 9 protein entries:     UBF1_HUMAN (see all proteins):
    UBTFL6    UBTFL1    SRY    HMGB1

    UBTF for paralogs           About GeneDecksing


    5/10 Pseudogenes.org Pseudogenes for UBTF (see all 10)
    PGOHUM00000257814 PGOHUM00000257847 PGOHUM00000257875 PGOHUM00000257901 PGOHUM00000257917


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/464 SNPs in UBTF are shown (see all 464)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397800221,2
    --38062774(+) CAGGGA/GAAAAA 2 -- us2k10--------
    rs1148189401,2
    C,F--42281949(+) GCTTCC/TCATCA 4 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1881936611,2
    --42281965(+) CTAGAC/TGGTCC 4 -- ds50010--------
    rs1178897401,2
    F--42282057(+) CCACGA/GTAAGC 4 -- ds50011Minor allele frequency- G:0.01EA 120
    rs1394416141,2
    --42282095(+) GGGCGA/GACCCT 4 -- ds50010--------
    rs1461155501,2
    C--42282225(+) TTGAG-/AGAAAA 4 -- ds50010--------
    rs342345171,2
    C,F--42282327(+) TGGCTT/GCAAGC 4 -- ds50013Minor allele frequency- G:0.04NA WA 122
    rs2001462601,2
    --42282408(+) AAACC-/TTTG  
            
    TTTTT
    4 -- ut31 nc-transcript-variant0--------
    rs1180196381,2
    C,F--42282452(+) ACTTCC/TACAGT 4 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.01NA 120
    rs1449948521,2
    C--42282602(+) TCCCAC/TCCCAG 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for UBTF (42282401 - 42298994 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for UBTF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510713CNV Loss20534489
    nsv908271CNV Loss21882294
    nsv908269CNV Loss21882294
    nsv908272CNV Loss21882294
    esv29087CNV Loss19812545
    nsv833455CNV Loss17160897
    nsv908270CNV Loss21882294
    dgv3174n71CNV Loss21882294
    dgv529n67CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UBTF
    DNA2.0 Custom Variant and Variant Library Synthesis for UBTF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600673    OMIM disorders: --

    9 diseases for UBTF:    About MalaCards
    treacher collins syndrome    systemic scleroderma    scleroderma    retinoblastoma
    herpes simplex    hepatitis c    hepatocellular carcinoma    hepatitis
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for UBTF:
    Systemic scleroderma

    UBTF for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for UBTF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiac hypertrophy 39.5 3 11511532 (2), 8593693 (1)
    hypertrophy 26.6 15 7713937 (3), 16079186 (2), 8710943 (2), 11511532 (2) (see all 7)
    retinoblastoma 26 1 16079186 (1)
    necrosis 0 3 16827655 (2), 11455567 (1)
    tumors 0 3 16827655 (2), 16079186 (1)


    Export disorders for UBTF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBTF gene, integrated from 9 sources (see all 199):
    (articles sorted by number of sources associating them with UBTF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping. (PubMed id 9126496)1, 3, 9 Matera A.G.... Chan E.K. (1997)
    2. Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins. (PubMed id 2330041)1, 2, 9 Jantzen H.M.... Tjian R. (1990)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor. (PubMed id 12590579)1, 2 Yang W.... Shi Y. (2003)
    5. Solution structure of the first HMG box domain in human upstream binding factor. (PubMed id 11969401)1, 2 Xu Y.... Shi Y. (2002)
    6. Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor. (PubMed id 1940801)1, 2 Chan E.K.L.... Tan E.M. (1991)
    7. Identification of two forms of the RNA polymerase I transcription factor UBF. (PubMed id 2014238)1, 9 O'Mahony D.J. and Rothblum L.I. (1991)
    8. Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription. (PubMed id 11698641)1, 9 Voit R. and Grummt I. (2001)
    9. The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor. (PubMed id 8552083)1, 9 Hempel W.M....Rothblum L.I. (1996)
    10. UBF activates RNA polymerase I transcription by stimulating promoter escape. (PubMed id 16858408)1, 9 Panov K.I....Zomerdijk J.C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7343 HGNC: 12511 AceView: UBTF Ensembl:ENSG00000108312 euGenes: HUgn7343
    ECgene: UBTF H-InvDB: UBTF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBTF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBTF gene:
    Search GeneIP for patents involving UBTF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of UBTF
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UBTF   OriGene RNAi products in human, mouse, rat for UBTF  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for UBTF  
     OriGene MassSpec something-or-other for UBTF   OriGene clones in human, mouse for UBTF  
     OriGene qSTAR qPCR primer pairs in human, mouse for UBTF   OriGene Purified Protein for UBTF  
     OriGene ORF clones in mouse, rat for UBTF   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UBTF   OriGene Custom Protein Services for UBTF  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBTF
     QIAGEN SeqTarget long-range PCR primers for resequencing UBTF
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBTF
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBTF
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBTF
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBTF
     GenScript Custom Purified and Recombinant Proteins Services for UBTF GenScript cDNA clones with any tag delivered in your preferred vector for UBTF
     GenScript Custom Assay Services for UBTF GenScript Custom Superior Antibodies Services for UBTF
     GenScript Custom overexpressing Cell Line Services for UBTF CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UBTF promoter
     Search Chromatin IP Primers for UBTF
     RT2 qPCR Primer Assay in human, mouse, rat UBTF
     GNC Network for UBTF
     SABiosciences PCR Arrays including human, mouse, rat UBTF
     Search Tocris compounds for UBTF (UBF1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UBTF antibodies
     UBTF proteins
     UBTF lysates
     Antibodies for UBTF
     See all of Abcam's Antibodies, Kits and Proteins for UBTF
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for UBTF
     Antibodies for UBTF
     ELISAs for UBTF
     CLIAs for UBTF
     Search LifeMap BioReagents cell lines for UBTF
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBTF
     SwitchGear 3'UTR luciferase reporter plasmids for UBTF
     SwitchGear Promoter luciferase reporter plasmids for UBTF
     Search ThermoFisher Antibodies for UBTF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBTF
     inGenious Targeting Laboratory - Custom generated mouse model solutions for UBTF
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBTF
    Customized:
     lentivirus for stable overexpression of UBTF
     lentivirus expression plasmids for stable overexpression of UBTF
     adenovirus for overexpression of UBTF
     LSBio Antibodies in human, mouse, rat for UBTF
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UBTF gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4