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Aliases for UBTD2 Gene

Aliases for UBTD2 Gene

  • Ubiquitin Domain Containing 2 2 3 5
  • Ubiquitin-Like Protein SB72 3 4
  • DCUBP 3 4
  • Dendritic Cell-Derived Ubiquitin-Like Protein 4
  • Dendritic Cell Derived Ubiquitin Like Protein 2
  • Ubiquitin Domain-Containing Protein 2 3
  • DC-UbP 4

External Ids for UBTD2 Gene

Previous GeneCards Identifiers for UBTD2 Gene

  • GC05M171573
  • GC05M166732

Summaries for UBTD2 Gene

GeneCards Summary for UBTD2 Gene

UBTD2 (Ubiquitin Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is UBTD1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBTD2 Gene

Genomics for UBTD2 Gene

Regulatory Elements for UBTD2 Gene

Enhancers for UBTD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G172596 0.9 dbSUPER 47.8 -313.8 -313757 2.0 ZNF473 ZSCAN4 ZFP64 ZNF354C EGR2 ZNF202 ZNF680 OVOL3 ZNF426 REST UBTD2 SH3PXD2B LOC100268168 LOC285593 GC05M172579 LOC105377729
GH05G172172 2.1 FANTOM5 Ensembl ENCODE dbSUPER 16.6 +102.8 102841 18.1 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A YBX1 ZNF2 ZBTB7B YY1 STK10 UBTD2 ENSG00000212529 GC05P172016
GH05G172763 2.4 VISTA FANTOM5 ENCODE dbSUPER 14.4 -488.1 -488129 16.8 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 DUSP1 CREBRF ERGIC1 UBTD2 SH3PXD2B LOC401218 LOC105377730 GC05M172780 ENSG00000206741
GH05G172436 1.5 Ensembl ENCODE dbSUPER 21.5 -153.5 -153470 2.6 PKNOX1 ATF1 ZNF133 SIN3A FEZF1 ZNF2 FOS DEK YY2 REST UBTD2 LOC100268168 SH3PXD2B GC05P172400
GH05G172360 1.6 FANTOM5 Ensembl ENCODE 17.5 -77.9 -77888 2.3 TBP ZSCAN4 SIN3A ZNF366 SCRT2 ZNF350 FOS ZNF548 ETV6 CREM SH3PXD2B NPM1 CREBRF UBTD2 STK10 DUSP1 PIR48158 PIR48190
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBTD2 on UCSC Golden Path with GeneCards custom track

Promoters for UBTD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for UBTD2 Gene

172,209,640 bp from pter
172,284,071 bp from pter
74,432 bases
Minus strand

Genomic View for UBTD2 Gene

Genes around UBTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBTD2 Gene

Proteins for UBTD2 Gene

  • Protein details for UBTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8TDQ3

    Protein attributes for UBTD2 Gene

    234 amino acids
    Molecular mass:
    26190 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH19910.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL99389.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBTD2 Gene

neXtProt entry for UBTD2 Gene

Post-translational modifications for UBTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBTD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBTD2 Gene

Domains & Families for UBTD2 Gene

Protein Domains for UBTD2 Gene

Suggested Antigen Peptide Sequences for UBTD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBTD2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for UBTD2 Gene

Function for UBTD2 Gene

Gene Ontology (GO) - Molecular Function for UBTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043130 ubiquitin binding IEA --
genes like me logo Genes that share ontologies with UBTD2: view
genes like me logo Genes that share phenotypes with UBTD2: view

Animal Model Products

CRISPR Products

miRNA for UBTD2 Gene

miRTarBase miRNAs that target UBTD2

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBTD2 Gene

Localization for UBTD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBTD2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBTD2 gene
Compartment Confidence
mitochondrion 2
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for UBTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBTD2: view

Pathways & Interactions for UBTD2 Gene

SuperPathways for UBTD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBTD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for UBTD2 Gene

Drugs & Compounds for UBTD2 Gene

No Compound Related Data Available

Transcripts for UBTD2 Gene

mRNA/cDNA for UBTD2 Gene

Unigene Clusters for UBTD2 Gene

Ubiquitin domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBTD2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b

Relevant External Links for UBTD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBTD2 Gene

Protein differential expression in normal tissues from HIPED for UBTD2 Gene

This gene is overexpressed in Fetal Brain (46.2) and Urine (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBTD2 Gene

Protein tissue co-expression partners for UBTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBTD2 Gene:


SOURCE GeneReport for Unigene cluster for UBTD2 Gene:


mRNA Expression by UniProt/SwissProt for UBTD2 Gene:

Tissue specificity: Detected in dendritic cells. Highly expressed in tumor cell lines, but not detectable in most tissues.

Evidence on tissue expression from TISSUES for UBTD2 Gene

  • Spleen(4.4)
  • Lymph node(4.3)
  • Blood(4)
genes like me logo Genes that share expression patterns with UBTD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBTD2 Gene

Orthologs for UBTD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBTD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBTD2 34 35
  • 99.82 (n)
(Canis familiaris)
Mammalia UBTD2 34 35
  • 94.59 (n)
(Bos Taurus)
Mammalia UBTD2 34 35
  • 93.87 (n)
(Mus musculus)
Mammalia Ubtd2 34 16 35
  • 90.17 (n)
(Ornithorhynchus anatinus)
Mammalia UBTD2 35
  • 88 (a)
(Rattus norvegicus)
Mammalia Ubtd2 34
  • 87.2 (n)
(Monodelphis domestica)
Mammalia UBTD2 35
  • 66 (a)
(Gallus gallus)
Aves UBTD2 34 35
  • 83.9 (n)
(Anolis carolinensis)
Reptilia UBTD2 35
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubtd2 34
  • 81.62 (n)
Str.20052 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14979 34
(Danio rerio)
Actinopterygii ubtd2 34 35
  • 73.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1172 34 35
  • 54.56 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001747 34
  • 52.87 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G53400 34
  • 54.05 (n)
(Oryza sativa)
Liliopsida Os09g0345000 34
  • 57.99 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5948 35
  • 51 (a)
Species where no ortholog for UBTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBTD2 Gene

Gene Tree for UBTD2 (if available)
Gene Tree for UBTD2 (if available)

Paralogs for UBTD2 Gene

Paralogs for UBTD2 Gene

(3) SIMAP similar genes for UBTD2 Gene using alignment to 1 proteins: Pseudogenes for UBTD2 Gene

genes like me logo Genes that share paralogs with UBTD2: view

Variants for UBTD2 Gene

Sequence variations from dbSNP and Humsavar for UBTD2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000014923 -- 172,285,171(+) AGCTT(A/G)GGATT upstream-variant-2KB
rs1000044577 -- 172,217,452(+) AATAA(A/G)CAAAG intron-variant
rs1000044931 -- 172,247,002(+) GCCTG(C/T)CTCAG intron-variant
rs1000090845 -- 172,257,631(+) CATCA(C/G)ATCTG intron-variant
rs1000123292 -- 172,210,020(+) CTTTG(A/G)TGACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBTD2 Gene

Variant ID Type Subtype PubMed ID
dgv3214n106 CNV deletion 24896259
esv2731093 CNV deletion 23290073
esv2759392 CNV gain+loss 17122850
nsv1015251 CNV gain 25217958
nsv1033257 CNV gain 25217958
nsv1074348 CNV deletion 25765185
nsv830554 CNV loss 17160897

Variation tolerance for UBTD2 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBTD2 Gene

Disorders for UBTD2 Gene

Relevant External Links for UBTD2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBTD2 Gene

Publications for UBTD2 Gene

  1. Cloning and identification of a novel human ubiquitin-like protein, DC-UbP, from dendritic cells. (PMID: 12507522) Liu S. … Cao X. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 22 64
  2. Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells. (PMID: 15987890) Gao Y.-G. … Hu H.-Y. (Protein Sci. 2005) 3 4 22 64
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for UBTD2 Gene

Sources for UBTD2 Gene

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