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Aliases for UBTD2 Gene

Aliases for UBTD2 Gene

  • Ubiquitin Domain Containing 2 2 3 5
  • Ubiquitin-Like Protein SB72 3 4
  • DCUBP 3 4
  • Dendritic Cell-Derived Ubiquitin-Like Protein 4
  • Dendritic Cell Derived Ubiquitin Like Protein 2
  • Ubiquitin Domain-Containing Protein 2 3
  • DC-UbP 4

External Ids for UBTD2 Gene

Previous GeneCards Identifiers for UBTD2 Gene

  • GC05M171573
  • GC05M166732

Summaries for UBTD2 Gene

GeneCards Summary for UBTD2 Gene

UBTD2 (Ubiquitin Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is UBTD1.

Additional gene information for UBTD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBTD2 Gene

Genomics for UBTD2 Gene

Regulatory Elements for UBTD2 Gene

Enhancers for UBTD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H172596 0.9 dbSUPER 64.9 -313.8 -313757 1 ZNF473 ZSCAN4 ZFP64 ZNF354C EGR2 ZNF202 ZNF680 ZC3H11A OVOL3 REST UBTD2 SH3PXD2B CREBRF LOC100268168 LOC285593 BNIP1 LOC105377729 GC05M172579
GH05H172172 2.1 FANTOM5 Ensembl ENCODE dbSUPER 25 +102.8 102841 18 HDGF PKNOX1 ARID4B SIN3A YBX1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF207 STK10 UBTD2 NPM1 CREBRF ENSG00000212529 SH3PXD2B GC05P172016
GH05H172436 1.5 Ensembl ENCODE dbSUPER 30.5 -153.5 -153470 2 PKNOX1 ATF1 ZNF133 FEZF1 ZNF2 FOS ATF7 DEK YY2 REST UBTD2 SH3PXD2B LOC100268168 GC05P172400
GH05H172894 2 FANTOM5 Ensembl ENCODE dbSUPER 19.5 -616.9 -616877 12 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B KLF3P1 BOD1 BNIP1 SH3PXD2B UBTD2 ERGIC1 DUSP1 ENSG00000253628 ENSG00000253172 CREBRF
GH05H172274 1.5 FANTOM5 Ensembl ENCODE 24.8 +8.4 8385 2 PKNOX1 FOXA2 KLF17 BRCA1 THRB ZEB1 ZNF366 ZSCAN5C ZNF143 RCOR1 NPM1 SH3PXD2B UBTD2 CREBRF EFCAB9 ENSG00000212529 RPL10P8 STK10 DUSP1 KLF3P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBTD2 on UCSC Golden Path with GeneCards custom track

Promoters for UBTD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000190749 571 3001 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 TCF12

Genomic Location for UBTD2 Gene

Chromosome:
5
Start:
172,209,640 bp from pter
End:
172,284,071 bp from pter
Size:
74,432 bases
Orientation:
Minus strand

Genomic View for UBTD2 Gene

Genes around UBTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBTD2 Gene

Proteins for UBTD2 Gene

  • Protein details for UBTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUN7-UBTD2_HUMAN
    Recommended name:
    Ubiquitin domain-containing protein 2
    Protein Accession:
    Q8WUN7
    Secondary Accessions:
    • Q8TDQ3

    Protein attributes for UBTD2 Gene

    Size:
    234 amino acids
    Molecular mass:
    26190 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH19910.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL99389.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBTD2 Gene

neXtProt entry for UBTD2 Gene

Post-translational modifications for UBTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBTD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBTD2 Gene

Domains & Families for UBTD2 Gene

Gene Families for UBTD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBTD2 Gene

Suggested Antigen Peptide Sequences for UBTD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBTD2: view

No data available for UniProtKB/Swiss-Prot for UBTD2 Gene

Function for UBTD2 Gene

Phenotypes From GWAS Catalog for UBTD2 Gene

Gene Ontology (GO) - Molecular Function for UBTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043130 ubiquitin binding IEA --
genes like me logo Genes that share ontologies with UBTD2: view
genes like me logo Genes that share phenotypes with UBTD2: view

Animal Model Products

CRISPR Products

miRNA for UBTD2 Gene

miRTarBase miRNAs that target UBTD2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UBTD2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBTD2 Gene

Localization for UBTD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBTD2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBTD2 gene
Compartment Confidence
mitochondrion 2
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for UBTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBTD2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UBTD2 Gene

Pathways & Interactions for UBTD2 Gene

SuperPathways for UBTD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBTD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBTD2 Gene

Drugs & Compounds for UBTD2 Gene

No Compound Related Data Available

Transcripts for UBTD2 Gene

mRNA/cDNA for UBTD2 Gene

Unigene Clusters for UBTD2 Gene

Ubiquitin domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UBTD2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for UBTD2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for UBTD2 Gene

GeneLoc Exon Structure for
UBTD2
ECgene alternative splicing isoforms for
UBTD2

Expression for UBTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBTD2 Gene

Protein differential expression in normal tissues from HIPED for UBTD2 Gene

This gene is overexpressed in Fetal Brain (46.2) and Urine (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBTD2 Gene



Protein tissue co-expression partners for UBTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBTD2 Gene:

UBTD2

SOURCE GeneReport for Unigene cluster for UBTD2 Gene:

Hs.131570

mRNA Expression by UniProt/SwissProt for UBTD2 Gene:

Q8WUN7-UBTD2_HUMAN
Tissue specificity: Detected in dendritic cells. Highly expressed in tumor cell lines, but not detectable in most tissues.

Evidence on tissue expression from TISSUES for UBTD2 Gene

  • Spleen(4.4)
  • Lymph node(4.3)
  • Blood(4)
genes like me logo Genes that share expression patterns with UBTD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBTD2 Gene

Orthologs for UBTD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBTD2 33 34
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia UBTD2 33 34
  • 94.59 (n)
cow
(Bos Taurus)
Mammalia UBTD2 33 34
  • 93.87 (n)
mouse
(Mus musculus)
Mammalia Ubtd2 33 16 34
  • 90.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBTD2 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubtd2 33
  • 87.2 (n)
oppossum
(Monodelphis domestica)
Mammalia UBTD2 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBTD2 33 34
  • 83.9 (n)
lizard
(Anolis carolinensis)
Reptilia UBTD2 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubtd2 33
  • 81.62 (n)
Str.20052 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14979 33
zebrafish
(Danio rerio)
Actinopterygii ubtd2 33 34
  • 73.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1172 33 34
  • 54.56 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001747 33
  • 52.87 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G53400 33
  • 54.05 (n)
rice
(Oryza sativa)
Liliopsida Os09g0345000 33
  • 57.99 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5948 34
  • 51 (a)
OneToMany
Species where no ortholog for UBTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBTD2 Gene

ENSEMBL:
Gene Tree for UBTD2 (if available)
TreeFam:
Gene Tree for UBTD2 (if available)

Paralogs for UBTD2 Gene

Paralogs for UBTD2 Gene

(3) SIMAP similar genes for UBTD2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for UBTD2 Gene

genes like me logo Genes that share paralogs with UBTD2: view

Variants for UBTD2 Gene

Sequence variations from dbSNP and Humsavar for UBTD2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000014923 -- 172,285,171(+) AGCTT(A/G)GGATT upstream-variant-2KB
rs1000044577 -- 172,217,452(+) AATAA(A/G)CAAAG intron-variant
rs1000044931 -- 172,247,002(+) GCCTG(C/T)CTCAG intron-variant
rs1000090845 -- 172,257,631(+) CATCA(C/G)ATCTG intron-variant
rs1000123292 -- 172,210,020(+) CTTTG(A/G)TGACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBTD2 Gene

Variant ID Type Subtype PubMed ID
dgv3214n106 CNV deletion 24896259
esv2731093 CNV deletion 23290073
esv2759392 CNV gain+loss 17122850
nsv1015251 CNV gain 25217958
nsv1033257 CNV gain 25217958
nsv1074348 CNV deletion 25765185
nsv830554 CNV loss 17160897

Variation tolerance for UBTD2 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBTD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBTD2 Gene

Disorders for UBTD2 Gene

Relevant External Links for UBTD2

Genetic Association Database (GAD)
UBTD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBTD2

No disorders were found for UBTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBTD2 Gene

Publications for UBTD2 Gene

  1. Cloning and identification of a novel human ubiquitin-like protein, DC-UbP, from dendritic cells. (PMID: 12507522) Liu S … Cao X (Biochemical and biophysical research communications 2003) 2 3 4 22 60
  2. Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells. (PMID: 15987890) Gao YG … Hu HY (Protein science : a publication of the Protein Society 2005) 3 4 22 60
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for UBTD2 Gene

Sources for UBTD2 Gene

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