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Aliases for UBTD2 Gene

Aliases for UBTD2 Gene

  • Ubiquitin Domain Containing 2 2 3 5
  • Ubiquitin-Like Protein SB72 3 4
  • DCUBP 3 4
  • Dendritic Cell-Derived Ubiquitin-Like Protein 4
  • Dendritic Cell Derived Ubiquitin Like Protein 2
  • DC-UbP 4

External Ids for UBTD2 Gene

Previous GeneCards Identifiers for UBTD2 Gene

  • GC05M171573
  • GC05M166732

Summaries for UBTD2 Gene

GeneCards Summary for UBTD2 Gene

UBTD2 (Ubiquitin Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is UBTD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBTD2 Gene

Genomics for UBTD2 Gene

Regulatory Elements for UBTD2 Gene

Enhancers for UBTD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBTD2 on UCSC Golden Path with GeneCards custom track

Promoters for UBTD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBTD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBTD2 Gene

172,209,640 bp from pter
172,284,071 bp from pter
74,432 bases
Minus strand

Genomic View for UBTD2 Gene

Genes around UBTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBTD2 Gene

Proteins for UBTD2 Gene

  • Protein details for UBTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8TDQ3

    Protein attributes for UBTD2 Gene

    234 amino acids
    Molecular mass:
    26190 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH19910.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL99389.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBTD2 Gene

neXtProt entry for UBTD2 Gene

Proteomics data for UBTD2 Gene at MOPED

Post-translational modifications for UBTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBTD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBTD2 Gene

Domains & Families for UBTD2 Gene

Protein Domains for UBTD2 Gene

Suggested Antigen Peptide Sequences for UBTD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ubiquitin-like domain.
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with UBTD2: view

No data available for Gene Families for UBTD2 Gene

Function for UBTD2 Gene

genes like me logo Genes that share phenotypes with UBTD2: view

Animal Model Products

miRNA for UBTD2 Gene

miRTarBase miRNAs that target UBTD2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBTD2 Gene

Localization for UBTD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBTD2 Gene


Subcellular locations from

Jensen Localization Image for UBTD2 Gene COMPARTMENTS Subcellular localization image for UBTD2 gene
Compartment Confidence
cytosol 2
mitochondrion 2
extracellular 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for UBTD2 Gene

Pathways & Interactions for UBTD2 Gene

SuperPathways for UBTD2 Gene

No Data Available

Interacting Proteins for UBTD2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000377381 Q8WUN7-UBTD2_HUMAN for UBTD2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for UBTD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for UBTD2 Gene

Drugs & Compounds for UBTD2 Gene

No Compound Related Data Available

Transcripts for UBTD2 Gene

mRNA/cDNA for UBTD2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(161) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UBTD2 Gene

Ubiquitin domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBTD2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b

Relevant External Links for UBTD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBTD2 Gene

mRNA expression in normal human tissues for UBTD2 Gene

Protein differential expression in normal tissues from HIPED for UBTD2 Gene

This gene is overexpressed in Fetal Brain (46.2) and Urine (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBTD2 Gene

SOURCE GeneReport for Unigene cluster for UBTD2 Gene Hs.131570

mRNA Expression by UniProt/SwissProt for UBTD2 Gene

Tissue specificity: Detected in dendritic cells. Highly expressed in tumor cell lines, but not detectable in most tissues.
genes like me logo Genes that share expression patterns with UBTD2: view

Protein tissue co-expression partners for UBTD2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UBTD2 Gene

Orthologs for UBTD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBTD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UBTD2 35
  • 93.87 (n)
  • 97.01 (a)
UBTD2 36
  • 97 (a)
(Canis familiaris)
Mammalia UBTD2 35
  • 94.59 (n)
  • 97.86 (a)
UBTD2 36
  • 98 (a)
(Mus musculus)
Mammalia Ubtd2 35
  • 90.17 (n)
  • 97.01 (a)
Ubtd2 16
Ubtd2 36
  • 97 (a)
(Pan troglodytes)
Mammalia UBTD2 35
  • 99.82 (n)
  • 100 (a)
UBTD2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ubtd2 35
  • 87.2 (n)
  • 97.16 (a)
(Monodelphis domestica)
Mammalia UBTD2 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia UBTD2 36
  • 88 (a)
(Gallus gallus)
Aves UBTD2 35
  • 83.9 (n)
  • 93.59 (a)
UBTD2 36
  • 94 (a)
(Anolis carolinensis)
Reptilia UBTD2 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20052 35
ubtd2 35
  • 81.62 (n)
  • 92.31 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14979 35
(Danio rerio)
Actinopterygii ubtd2 35
  • 73.79 (n)
  • 84.62 (a)
ubtd2 36
  • 81 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001747 35
  • 52.87 (n)
  • 51.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1172 35
  • 54.56 (n)
  • 52.02 (a)
CG1172 36
  • 47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G53400 35
  • 54.05 (n)
  • 53.4 (a)
(Oryza sativa)
Liliopsida Os09g0345000 35
  • 57.99 (n)
  • 52.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5948 36
  • 51 (a)
Species with no ortholog for UBTD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBTD2 Gene

Gene Tree for UBTD2 (if available)
Gene Tree for UBTD2 (if available)

Paralogs for UBTD2 Gene

Paralogs for UBTD2 Gene

(3) SIMAP similar genes for UBTD2 Gene using alignment to 1 proteins: Pseudogenes for UBTD2 Gene

genes like me logo Genes that share paralogs with UBTD2: view

Variants for UBTD2 Gene

Sequence variations from dbSNP and Humsavar for UBTD2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17074452 - 172,212,148(+) TCTAT(C/T)ATGTT reference, missense
rs9043 -- 172,209,922(+) CAAAT(C/T)TGCTT utr-variant-3-prime
rs2879452 -- 172,232,434(+) AACAT(C/T)AGTAA intron-variant
rs1038780 -- 172,212,483(-) ATGCC(A/G)TTTTA intron-variant
rs1059302 -- 172,210,343(-) GCCCT(C/G)CACAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBTD2 Gene

Variant ID Type Subtype PubMed ID
dgv1872e1 CNV Complex 17122850
nsv830554 CNV Loss 17160897
esv2731093 CNV Deletion 23290073

Variation tolerance for UBTD2 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UBTD2 Gene

Disorders for UBTD2 Gene

Relevant External Links for UBTD2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBTD2 Gene

Publications for UBTD2 Gene

  1. Cloning and identification of a novel human ubiquitin-like protein, DC-UbP, from dendritic cells. (PMID: 12507522) Liu S. … Cao X. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23 67
  2. Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells. (PMID: 15987890) Gao Y.-G. … Hu H.-Y. (Protein Sci. 2005) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A ubiquitin shuttle DC-UbP/UBTD2 reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes. (PMID: 25207809) Song A.X. … Hu H.Y. (PLoS ONE 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for UBTD2 Gene

Sources for UBTD2 Gene