UBTD2 Gene
protein-coding GIFtS: 49
GCID: GC05M171573
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ubiquitin domain containing 2
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Aliases
for UBTD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Domain Containing 21 2 | | MGC300221 5 | | DCUBP2 3 5 | | Ubiquitin Domain-Containing Protein 22 | | DC-UbP1 3 | | Dendritic Cell-Derived Ubiquitin-Like Protein3 | | Ubiquitin-Like Protein SB722 3 | | |
Export aliases for UBTD2 gene to outside databasesPrevious GC identifer: GC05M166732 |
Summaries
for UBTD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for UBTD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBTD2 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 Max1 Sox5 oct-B3 oct-B2 POU2F2 POU2F2C POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBTD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBTD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.1 Ensembl cytogenetic band: 5q35.1 HGNC cytogenetic band: 5q35.1UBTD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M171573: view genomic region
(about GC identifiers)
Start:
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171,636,644 bp from pter |
End:
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171,711,075 bp from pter |
Size:
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74,432 bases |
Orientation:
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minus strand |
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Proteins
for UBTD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBTD2_HUMAN, Q8WUN7 (See
protein sequence)Recommended Name: Ubiquitin domain-containing protein 2 Size: 234 amino acids; 26190 Da
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAH19910.1; Type=Erroneous initiation; Sequence=AAL99389.1; Type=Erroneous initiation;
2 PDB 3D structures from  and Proteopedia  for UBTD2:1TTN (3D)
2KSN (3D)
Secondary accessions: Q8TDQ3Explore the universe of human proteins at neXtProt for UBTD2: NX_Q8WUN7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WUN7
UBTD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689490.2
ENSEMBL proteins: ENSP00000377381
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
UBTD2 for ontologies About GeneDecksing
UBTD2 Antibody Products:
Assay Products for UBTD2: |
Protein
Domains /
Families
for UBTD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBTD2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WUN7ProtoNet protein and cluster: Q8WUN7 1 Blocks protein family: IPB000626 Ubiquitin domain
UniProtKB/Swiss-Prot: UBTD2_HUMAN, Q8WUN7Similarity: Contains 1 ubiquitin-like domain |
Function
for UBTD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBTD2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBTD2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBTD2 |
|
Pathways & Interactions
for UBTD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBTD2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for UBTD2 (Q8WUN73 ENSP000003773814) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for UBTD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBTD2
Search CenterWatch for drugs/clinical trials and news about UBTD2
|
Transcripts
for UBTD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBTD2 gene: NM_152277.2 Unigene Cluster for UBTD2: Ubiquitin domain containing 2 Hs.131570 [show with all ESTs]Unigene Representative Sequence: NM_1522771 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000393792(uc003mbp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBTD2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBTD2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBTD2 (NM_152277) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBTD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBTD2 |
Additional cDNA sequence: AF251700.1 AK022894.1 AK313274.1 BC019910.1 4 DOTS entries: DT.314536 DT.100814997 DT.120827985 DT.100814999 24/161 AceView cDNA sequences (see all 161): AI123045 AI336003 BE671854 CR604922 BU521662 AL550069 CR591327 AA310365 BU176823 AA195582 AA659002 AI683146 BU902027 AI284268 AI261760 AI264194 AI380370 AA412222 AI954140 BU618250 AA954434 AI572264 BU849695 BX437704
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for UBTD2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b |
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| SP1: | | | | | | | | | |
| SP2: | | | | | | | | |
ECgene alternative splicing isoforms for UBTD2
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Expression
for UBTD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBTD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCTGTTTA
About this image
See UBTD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBTD2
SOURCE GeneReport for Unigene cluster: Hs.131570
UniProtKB/Swiss-Prot: UBTD2_HUMAN, Q8WUN7Tissue specificity: Detected in dendritic cells. Highly expressed in tumor cell lines, but not detectable in mosttissues
SABiosciences Custom PCR Arrays for UBTD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBTD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBTD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBTD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBTD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBTD2 |
Orthologs
for UBTD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBTD2 gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for UBTD2 (if available)
TreeFam Gene Tree for UBTD2 (if available) |
Paralogs
for UBTD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBTD2 gene
- UBTD12
3 SIMAP similar genes for UBTD2 using alignment to 1 protein entry: UBTD2_HUMAN:DC-UbP UBTD1 NEDD8
UBTD2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for UBTD2
PGOHUM00000238222
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Genomic Variants
for UBTD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBTD2 (171636644 - 171711075 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UBTD2
1 CNV: 3586 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBTD2 |
|
Disorders
/ Diseases
for UBTD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBTD2 for disorders About GeneDecksing
OMIM gene information: 610174
OMIM disorders: --
3  diseases for UBTD2: About MalaCardsvesicoureteral reflux holoprosencephaly polydactyly
1 disease from the University of Copenhagen DISEASES database for UBTD2:Vesicoureteral reflux Export disorders for UBTD2 gene to outside databases
|
Publications
for UBTD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBTD2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with UBTD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and identification of a novel human ubiquitin-like protein, DC-UbP, from dendritic cells. (PubMed id 12507522)1, 2, 3, 9 Liu S....Cao X. (2003)
- Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells. (PubMed id 15987890)1, 2, 9 Gao Y.-G.... Hu H.-Y. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Solution structure of the N-terminal domain of DC-UbP /UBTD2 and its interaction with ubiquitin. (PubMed id 20440844)1 Song A.X....Hu H.Y. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
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External Searches for UBTD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing UBTD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBTD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBTD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBTD2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBTD2 gene:
Search GeneIP for patents involving UBTD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBTD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UBTD2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBTD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBTD2 | | | OriGene Protein Over-expression Lysate for UBTD2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBTD2 | | OriGene 3'-UTR Clone for UBTD2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBTD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBTD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBTD2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBTD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBTD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBTD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBTD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBTD2 |
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 | | | UBTD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBTD2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBTD2 |
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