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Aliases for UBTD1 Gene

Aliases for UBTD1 Gene

  • Ubiquitin Domain Containing 1 2 3 5

External Ids for UBTD1 Gene

Previous GeneCards Identifiers for UBTD1 Gene

  • GC10P098924
  • GC10P099248
  • GC10P092884

Summaries for UBTD1 Gene

Entrez Gene Summary for UBTD1 Gene

  • The degradation of many proteins is carried out by the ubiquitin pathway in which proteins are targeted for degradation by covalent conjugation of the polypeptide ubiquitin. This gene encodes a protein that belongs to the ubiquitin family of proteins. The encoded protein is thought to regulate E2 ubiquitin conjugating enzymes belonging to the UBE2D family. [provided by RefSeq, Mar 2014]

GeneCards Summary for UBTD1 Gene

UBTD1 (Ubiquitin Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is UBTD2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBTD1 Gene

Genomics for UBTD1 Gene

Regulatory Elements for UBTD1 Gene

Enhancers for UBTD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBTD1 on UCSC Golden Path with GeneCards custom track

Promoters for UBTD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBTD1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UBTD1 gene promoter:

Genomic Location for UBTD1 Gene

97,498,868 bp from pter
97,571,210 bp from pter
72,343 bases
Plus strand

Genomic View for UBTD1 Gene

Genes around UBTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBTD1 Gene

Proteins for UBTD1 Gene

  • Protein details for UBTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DR57
    • Q53HI3

    Protein attributes for UBTD1 Gene

    227 amino acids
    Molecular mass:
    25938 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UBTD1 Gene

Proteomics data for UBTD1 Gene at MOPED

Post-translational modifications for UBTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBTD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBTD1 Gene

Domains & Families for UBTD1 Gene

Protein Domains for UBTD1 Gene

Suggested Antigen Peptide Sequences for UBTD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ubiquitin-like domain.
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with UBTD1: view

No data available for Gene Families for UBTD1 Gene

Function for UBTD1 Gene

Gene Ontology (GO) - Molecular Function for UBTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043130 ubiquitin binding IEA --
genes like me logo Genes that share ontologies with UBTD1: view
genes like me logo Genes that share phenotypes with UBTD1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UBTD1 Gene

Localization for UBTD1 Gene

Subcellular locations from

Jensen Localization Image for UBTD1 Gene COMPARTMENTS Subcellular localization image for UBTD1 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBTD1 Gene

Pathways & Interactions for UBTD1 Gene

SuperPathways for UBTD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBTD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for UBTD1 Gene

Drugs & Compounds for UBTD1 Gene

No Compound Related Data Available

Transcripts for UBTD1 Gene

mRNA/cDNA for UBTD1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(118) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UBTD1 Gene

Ubiquitin domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBTD1 Gene

No ASD Table

Relevant External Links for UBTD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBTD1 Gene

mRNA expression in normal human tissues for UBTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBTD1 Gene

This gene is overexpressed in Breast (42.5), Testis (15.7), and Ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBTD1 Gene

SOURCE GeneReport for Unigene cluster for UBTD1 Gene Hs.500724

genes like me logo Genes that share expression patterns with UBTD1: view

Protein tissue co-expression partners for UBTD1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBTD1 Gene

Orthologs for UBTD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBTD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UBTD1 35
  • 93.83 (n)
  • 98.68 (a)
UBTD1 36
  • 99 (a)
(Canis familiaris)
Mammalia UBTD1 35
  • 93.33 (n)
  • 98.54 (a)
UBTD1 36
  • 80 (a)
(Mus musculus)
Mammalia Ubtd1 35
  • 90.9 (n)
  • 98.68 (a)
Ubtd1 16
Ubtd1 36
  • 99 (a)
(Pan troglodytes)
Mammalia UBTD1 35
  • 99.56 (n)
  • 100 (a)
UBTD1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ubtd1 35
  • 92.66 (n)
  • 99.12 (a)
(Ornithorhynchus anatinus)
Mammalia UBTD1 36
  • 78 (a)
(Gallus gallus)
Aves UBTD1 35
  • 81.86 (n)
  • 83.72 (a)
UBTD1 36
  • 81 (a)
(Anolis carolinensis)
Reptilia UBTD1 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubtd1 35
  • 72.37 (n)
  • 78.24 (a)
(Danio rerio)
Actinopterygii ubtd1b 35
  • 69.79 (n)
  • 74.55 (a)
ubtd1a 36
  • 67 (a)
ubtd1b 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1172 36
  • 44 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G45740 35
  • 52.22 (n)
  • 50 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8466 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5948 36
  • 52 (a)
Species with no ortholog for UBTD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBTD1 Gene

Gene Tree for UBTD1 (if available)
Gene Tree for UBTD1 (if available)

Paralogs for UBTD1 Gene

Paralogs for UBTD1 Gene

(2) SIMAP similar genes for UBTD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBTD1: view

Variants for UBTD1 Gene

Sequence variations from dbSNP and Humsavar for UBTD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1572860 -- 97,551,225(+) AGACA(C/T)ATACA intron-variant
rs1572861 -- 97,525,043(+) AGAGT(A/C)TTTTC intron-variant
rs1572862 -- 97,525,063(+) TGCTG(A/C)GAGAA intron-variant
rs1890969 -- 97,516,329(+) CCCAG(A/G)CTTCT intron-variant
rs3066031 -- 97,539,939(-) GCCTC(-/AG)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBTD1 Gene

Variant ID Type Subtype PubMed ID
nsv7508 CNV Loss 18451855
esv1218822 CNV Deletion 17803354
esv992861 CNV Deletion 20482838
nsv7509 CNV Insertion 18451855

Variation tolerance for UBTD1 Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UBTD1 Gene

Disorders for UBTD1 Gene

Relevant External Links for UBTD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBTD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBTD1 Gene

Publications for UBTD1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop. (PMID: 25382750) Zhang X.W. … Guo W.J. (J. Pathol. 2015) 3
  4. The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. (PMID: 24211586) Uhler J.P. … Gustafsson C.M. (Biochem. Biophys. Res. Commun. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for UBTD1 Gene

Sources for UBTD1 Gene