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Aliases for UBTD1 Gene

Aliases for UBTD1 Gene

  • Ubiquitin Domain Containing 1 2 3 5

External Ids for UBTD1 Gene

Previous GeneCards Identifiers for UBTD1 Gene

  • GC10P098924
  • GC10P099248
  • GC10P092884

Summaries for UBTD1 Gene

Entrez Gene Summary for UBTD1 Gene

  • The degradation of many proteins is carried out by the ubiquitin pathway in which proteins are targeted for degradation by covalent conjugation of the polypeptide ubiquitin. This gene encodes a protein that belongs to the ubiquitin family of proteins. The encoded protein is thought to regulate E2 ubiquitin conjugating enzymes belonging to the UBE2D family. [provided by RefSeq, Mar 2014]

GeneCards Summary for UBTD1 Gene

UBTD1 (Ubiquitin Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is UBTD2.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBTD1 Gene

Genomics for UBTD1 Gene

Regulatory Elements for UBTD1 Gene

Enhancers for UBTD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G097537 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +42.5 42480 6.8 PKNOX1 ZFP64 SIN3A ARID4B ZNF2 YY1 ZNF121 GLIS2 FOS ZNF263 PI4K2A ANKRD2 UBTD1 MMS19 HOGA1 ENSG00000249967 C10orf62 RRP12 GC10P097540
GH10G097405 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -91.4 -91381 3.8 HDGF ATF1 MLX WRNIP1 ZFP64 ARID4B SIN3A ZNF2 ZNF48 TCF12 FRAT2 RRP12 FRAT1 ARHGAP19 EXOSC1 ZDHHC16 MMS19 UBTD1 ENSG00000249967 HOGA1
GH10G097412 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -84.8 -84801 3.1 ELF3 TBP ATF1 CBX3 NFRKB BMI1 RAD21 ZNF121 GATA2 ELK1 RRP12 EXOSC1 ZDHHC16 MMS19 UBTD1 PGAM1 LCOR ZFYVE27 ARHGAP19 FRAT1
GH10G097548 1 Ensembl ENCODE 17.2 +51.2 51151 2.2 TFAP4 KLF1 GLI4 ZIC2 ZFHX2 POLR2A ZNF366 ZBTB48 PATZ1 SCRT2 ANKRD2 UBTD1 MMS19 HOGA1 ENSG00000249967 C10orf62 PI4K2A GC10P097540
GH10G097595 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +97.9 97932 3.0 FOXA2 YY1 ZNF121 ZNF366 GATA2 FOS EGR2 NR2F2 ZNF592 MAFF ANKRD2 UBTD1 MMS19 C10orf62 MORN4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBTD1 on UCSC Golden Path with GeneCards custom track

Promoters for UBTD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000032180 -68 2801 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Transcription factor binding sites by QIAGEN in the UBTD1 gene promoter:

Genomic Location for UBTD1 Gene

Chromosome:
10
Start:
97,498,868 bp from pter
End:
97,571,210 bp from pter
Size:
72,343 bases
Orientation:
Plus strand

Genomic View for UBTD1 Gene

Genes around UBTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBTD1 Gene

Proteins for UBTD1 Gene

  • Protein details for UBTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAC8-UBTD1_HUMAN
    Recommended name:
    Ubiquitin domain-containing protein 1
    Protein Accession:
    Q9HAC8
    Secondary Accessions:
    • D3DR57
    • Q53HI3

    Protein attributes for UBTD1 Gene

    Size:
    227 amino acids
    Molecular mass:
    25938 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UBTD1 Gene

Post-translational modifications for UBTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBTD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBTD1 Gene

Domains & Families for UBTD1 Gene

Protein Domains for UBTD1 Gene

Suggested Antigen Peptide Sequences for UBTD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBTD1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for UBTD1 Gene

Function for UBTD1 Gene

Gene Ontology (GO) - Molecular Function for UBTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0043130 ubiquitin binding IEA --
genes like me logo Genes that share ontologies with UBTD1: view
genes like me logo Genes that share phenotypes with UBTD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UBTD1 Gene

Localization for UBTD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBTD1 gene
Compartment Confidence
plasma membrane 2
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBTD1 Gene

Pathways & Interactions for UBTD1 Gene

SuperPathways for UBTD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBTD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBTD1 Gene

Transcripts for UBTD1 Gene

mRNA/cDNA for UBTD1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(118) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UBTD1 Gene

Ubiquitin domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBTD1 Gene

No ASD Table

Relevant External Links for UBTD1 Gene

GeneLoc Exon Structure for
UBTD1
ECgene alternative splicing isoforms for
UBTD1

Expression for UBTD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBTD1 Gene

This gene is overexpressed in Breast (42.5), Testis (15.7), and Ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBTD1 Gene



Protein tissue co-expression partners for UBTD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBTD1 Gene:

UBTD1

SOURCE GeneReport for Unigene cluster for UBTD1 Gene:

Hs.500724
genes like me logo Genes that share expression patterns with UBTD1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBTD1 Gene

Orthologs for UBTD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBTD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBTD1 34 35
  • 99.56 (n)
cow
(Bos Taurus)
Mammalia UBTD1 34 35
  • 93.83 (n)
dog
(Canis familiaris)
Mammalia UBTD1 34 35
  • 93.33 (n)
rat
(Rattus norvegicus)
Mammalia Ubtd1 34
  • 92.66 (n)
mouse
(Mus musculus)
Mammalia Ubtd1 34 16 35
  • 90.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBTD1 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBTD1 34 35
  • 81.86 (n)
lizard
(Anolis carolinensis)
Reptilia UBTD1 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubtd1 34
  • 72.37 (n)
zebrafish
(Danio rerio)
Actinopterygii ubtd1b 34 35
  • 69.79 (n)
ubtd1a 35
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1172 35
  • 44 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G45740 34
  • 52.22 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5948 35
  • 52 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8466 34
Species where no ortholog for UBTD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBTD1 Gene

ENSEMBL:
Gene Tree for UBTD1 (if available)
TreeFam:
Gene Tree for UBTD1 (if available)

Paralogs for UBTD1 Gene

Paralogs for UBTD1 Gene

(2) SIMAP similar genes for UBTD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBTD1: view

Variants for UBTD1 Gene

Sequence variations from dbSNP and Humsavar for UBTD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000014381 -- 97,544,609(+) ACATG(A/T)ACAGT intron-variant
rs1000021802 -- 97,511,064(+) TCAGC(C/T)GCAGA intron-variant
rs1000051311 -- 97,511,460(+) GTTTA(C/T)TGATG intron-variant
rs1000054157 -- 97,552,704(+) GGCCA(A/G)TACAT intron-variant
rs1000088745 -- 97,562,806(+) TAGGT(C/T)ACAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBTD1 Gene

Variant ID Type Subtype PubMed ID
esv1218822 CNV deletion 17803354
esv3348273 CNV insertion 20981092
esv3624316 CNV loss 21293372
esv992861 CNV deletion 20482838
nsv1036494 CNV gain 25217958
nsv1047359 CNV gain 25217958
nsv1110852 OTHER inversion 24896259
nsv7508 CNV deletion 18451855
nsv7509 CNV insertion 18451855

Variation tolerance for UBTD1 Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBTD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBTD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBTD1 Gene

Disorders for UBTD1 Gene

Relevant External Links for UBTD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBTD1

No disorders were found for UBTD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBTD1 Gene

Publications for UBTD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. (PMID: 26752685) Scholz C.C. … Taylor C.T. (PLoS Biol. 2016) 3 64

Products for UBTD1 Gene

Sources for UBTD1 Gene

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