Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBR7 Gene

Aliases for UBR7 Gene

  • Ubiquitin Protein Ligase E3 Component N-Recognin 7 (Putative) 2 3 5
  • RING-Type E3 Ubiquitin Transferase UBR7 3 4
  • N-Recognin-7 3 4
  • C14orf130 3 4
  • Putative E3 Ubiquitin-Protein Ligase UBR7 3
  • Chromosome 14 Open Reading Frame 130 2
  • EC 2.3.2.27 4

External Ids for UBR7 Gene

Previous HGNC Symbols for UBR7 Gene

  • C14orf130

Previous GeneCards Identifiers for UBR7 Gene

  • GC14P092744
  • GC14P093673
  • GC14P073853

Summaries for UBR7 Gene

Entrez Gene Summary for UBR7 Gene

  • This gene encodes a UBR box-containing protein that belongs to the E3 ubiquitin ligase family. The protein also contains a plant homeodomain (PHD) in the C-terminus. In mammals, the encoded protein recognizes N-degrons, the destabilizing N-terminal residues of short-lived proteins, which results in ubiquitinylation, and proteolysis via the proteasome. [provided by RefSeq, Jul 2016]

GeneCards Summary for UBR7 Gene

UBR7 (Ubiquitin Protein Ligase E3 Component N-Recognin 7 (Putative)) is a Protein Coding gene. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is ENSG00000259066.

UniProtKB/Swiss-Prot for UBR7 Gene

  • E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

Additional gene information for UBR7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBR7 Gene

Genomics for UBR7 Gene

Regulatory Elements for UBR7 Gene

Enhancers for UBR7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H093953 2 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +752.9 752945 13 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 BTBD7 SERPINA1 CCDC197 DDX24 UBR7 IFI27L2 IFI27 RPSAP4 FAM181A-AS1 ASB2
GH14H093860 0.6 ENCODE 11.2 +653.2 653174 0 ZNF664 NFIC NFIB ZNF341 ZNF624 ZNF491 ZIC2 UBR7 LOC105370631 PRIMA1
GH14H093298 1.3 Ensembl ENCODE dbSUPER 5 +95.9 95934 9 PKNOX1 ZNF146 KLF1 ZSCAN4 ZNF223 ZNF2 HIC1 ZNF121 GATA3 ZNF316 BTBD7 UNC79 COX8C UBR7 ENSG00000241499
GH14H093322 1.2 Ensembl ENCODE dbSUPER 4.5 +116.7 116723 2 HDAC1 PKNOX1 ZNF316 NFE2 ATF7 MAFK ZNF362 MAFG CEBPB DPF2 COX8C UNC79 OTUB2 UBR7 BTBD7 ENSG00000241499
GH14H093183 1.1 ENCODE 0.3 -22.0 -22041 3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF207 SP3 SP5 BTBD7 GOLGA5 MOAP1 ENSG00000259066 UBR7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBR7 on UCSC Golden Path with GeneCards custom track

Promoters for UBR7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000072394 144 2401 HDGF PKNOX1 ARID4B SIN3A FEZF1 YBX1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for UBR7 Gene

Chromosome:
14
Start:
93,207,056 bp from pter
End:
93,229,215 bp from pter
Size:
22,160 bases
Orientation:
Plus strand

Genomic View for UBR7 Gene

Genes around UBR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBR7 Gene

Proteins for UBR7 Gene

  • Protein details for UBR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N806-UBR7_HUMAN
    Recommended name:
    Putative E3 ubiquitin-protein ligase UBR7
    Protein Accession:
    Q8N806
    Secondary Accessions:
    • Q86U21
    • Q86UA9
    • Q96BY0
    • Q9NVV6

    Protein attributes for UBR7 Gene

    Size:
    425 amino acids
    Molecular mass:
    47999 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15046.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH51819.4; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91639.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UBR7 Gene

Post-translational modifications for UBR7 Gene

  • Ubiquitination at Lys384, Lys398, and posLast=413413
  • Modification sites at PhosphoSitePlus

Other Protein References for UBR7 Gene

No data available for DME Specific Peptides for UBR7 Gene

Domains & Families for UBR7 Gene

Gene Families for UBR7 Gene

Protein Domains for UBR7 Gene

Suggested Antigen Peptide Sequences for UBR7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBR7: view

No data available for UniProtKB/Swiss-Prot for UBR7 Gene

Function for UBR7 Gene

Molecular function for UBR7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

Enzyme Numbers (IUBMB) for UBR7 Gene

Phenotypes From GWAS Catalog for UBR7 Gene

Gene Ontology (GO) - Molecular Function for UBR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with UBR7: view
genes like me logo Genes that share phenotypes with UBR7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UBR7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBR7 Gene

Localization for UBR7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBR7 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBR7 Gene

Pathways & Interactions for UBR7 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N806-UBR7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with UBR7: view

No data available for Pathways by source and SIGNOR curated interactions for UBR7 Gene

Drugs & Compounds for UBR7 Gene

No Compound Related Data Available

Transcripts for UBR7 Gene

Unigene Clusters for UBR7 Gene

Ubiquitin protein ligase E3 component n-recognin 7 (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UBR7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for UBR7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1:
SP2: -
SP3: -

Relevant External Links for UBR7 Gene

GeneLoc Exon Structure for
UBR7
ECgene alternative splicing isoforms for
UBR7

Expression for UBR7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBR7 Gene

Protein differential expression in normal tissues from HIPED for UBR7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.8), Blymphocyte (11.8), Testis (9.8), and Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBR7 Gene



Protein tissue co-expression partners for UBR7 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBR7 Gene:

UBR7

SOURCE GeneReport for Unigene cluster for UBR7 Gene:

Hs.648806

mRNA Expression by UniProt/SwissProt for UBR7 Gene:

Q8N806-UBR7_HUMAN
Tissue specificity: Expressed in sperm (at protein level).

Evidence on tissue expression from TISSUES for UBR7 Gene

  • Nervous system(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with UBR7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBR7 Gene

Orthologs for UBR7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBR7 33 34
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 92 (a)
OneToMany
UBR7 33
  • 91.22 (n)
cow
(Bos Taurus)
Mammalia UBR7 33 34
  • 91.14 (n)
rat
(Rattus norvegicus)
Mammalia Ubr7 33
  • 87.06 (n)
mouse
(Mus musculus)
Mammalia Ubr7 33 16 34
  • 86.12 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves UBR7 33 34
  • 73.17 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ubr7 33
  • 67.25 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398523 33
zebrafish
(Danio rerio)
Actinopterygii ubr7 33 34
  • 61.83 (n)
Dr.503 33
fruit fly
(Drosophila melanogaster)
Insecta CG15141 33 34
  • 50.76 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009512 33
  • 49.44 (n)
worm
(Caenorhabditis elegans)
Secernentea T22C1.1 33 34
  • 48.26 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G23860 33
  • 52.33 (n)
rice
(Oryza sativa)
Liliopsida Os06g0529800 33
  • 51.12 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.6152 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 56 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.821 33
Species where no ortholog for UBR7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBR7 Gene

ENSEMBL:
Gene Tree for UBR7 (if available)
TreeFam:
Gene Tree for UBR7 (if available)

Paralogs for UBR7 Gene

Paralogs for UBR7 Gene

(1) SIMAP similar genes for UBR7 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with UBR7: view

Variants for UBR7 Gene

Sequence variations from dbSNP and Humsavar for UBR7 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs751474426 Likely benign 93,210,656(+) TTTTC(A/G)TTGTG nc-transcript-variant, reference, missense
rs1000058553 -- 93,208,895(+) TGGGT(G/T)CAAGT intron-variant, upstream-variant-2KB
rs1000623525 -- 93,208,162(+) CTCAC(C/G)CTACA intron-variant, upstream-variant-2KB
rs1000696486 -- 93,209,650(+) TGCAA(C/T)GCAAC intron-variant
rs1000879795 -- 93,221,637(+) AAAAG(A/T)TACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBR7 Gene

Variant ID Type Subtype PubMed ID
esv3635357 CNV gain 21293372
nsv516487 CNV loss 19592680
nsv974368 CNV duplication 23825009

Variation tolerance for UBR7 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBR7 Gene

Human Gene Mutation Database (HGMD)
UBR7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBR7 Gene

Disorders for UBR7 Gene

Relevant External Links for UBR7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBR7

No disorders were found for UBR7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBR7 Gene

Publications for UBR7 Gene

  1. Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa. (PMID: 24664117) Zimmerman SW … Sutovsky P (Cell and tissue research 2014) 3 4 60
  2. Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway. (PMID: 18162545) Lee MJ … Kwon YT (Proceedings of the National Academy of Sciences of the United States of America 2008) 2 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for UBR7 Gene

Sources for UBR7 Gene

Content
Loading form....