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Aliases for UBR7 Gene

Aliases for UBR7 Gene

  • Ubiquitin Protein Ligase E3 Component N-Recognin 7 (Putative) 2 3 5
  • N-Recognin-7 3 4
  • C14orf130 3 4
  • Chromosome 14 Open Reading Frame 130 2
  • EC 6.3.2.- 4

External Ids for UBR7 Gene

Previous HGNC Symbols for UBR7 Gene

  • C14orf130

Previous GeneCards Identifiers for UBR7 Gene

  • GC14P092744
  • GC14P093673
  • GC14P073853

Summaries for UBR7 Gene

GeneCards Summary for UBR7 Gene

UBR7 (Ubiquitin Protein Ligase E3 Component N-Recognin 7 (Putative)) is a Protein Coding gene. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is ENSG00000259066.

UniProtKB/Swiss-Prot for UBR7 Gene

  • E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBR7 Gene

Genomics for UBR7 Gene

Regulatory Elements for UBR7 Gene

Promoters for UBR7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBR7 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBR7 Gene

Chromosome:
14
Start:
93,207,056 bp from pter
End:
93,229,215 bp from pter
Size:
22,160 bases
Orientation:
Plus strand

Genomic View for UBR7 Gene

Genes around UBR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBR7 Gene

Proteins for UBR7 Gene

  • Protein details for UBR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N806-UBR7_HUMAN
    Recommended name:
    Putative E3 ubiquitin-protein ligase UBR7
    Protein Accession:
    Q8N806
    Secondary Accessions:
    • Q86U21
    • Q86UA9
    • Q96BY0
    • Q9NVV6

    Protein attributes for UBR7 Gene

    Size:
    425 amino acids
    Molecular mass:
    47999 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15046.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH51819.4; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91639.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UBR7 Gene

Proteomics data for UBR7 Gene at MOPED

Post-translational modifications for UBR7 Gene

  • Ubiquitination at Lys 384, Lys 398, and Lys 413
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for UBR7 Gene

Domains & Families for UBR7 Gene

Protein Domains for UBR7 Gene

Suggested Antigen Peptide Sequences for UBR7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N806

UniProtKB/Swiss-Prot:

UBR7_HUMAN :
  • Contains 1 PHD-type zinc finger.
Similarity:
  • Contains 1 PHD-type zinc finger.
  • Contains 1 UBR-type zinc finger.
genes like me logo Genes that share domains with UBR7: view

Function for UBR7 Gene

Molecular function for UBR7 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).

Enzyme Numbers (IUBMB) for UBR7 Gene

Gene Ontology (GO) - Molecular Function for UBR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with UBR7: view
genes like me logo Genes that share phenotypes with UBR7: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBR7 Gene

Localization for UBR7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBR7 Gene COMPARTMENTS Subcellular localization image for UBR7 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBR7 Gene

Pathways & Interactions for UBR7 Gene

SuperPathways for UBR7 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N806-UBR7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with UBR7: view

No data available for Pathways by source and SIGNOR curated interactions for UBR7 Gene

Drugs & Compounds for UBR7 Gene

No Compound Related Data Available

Transcripts for UBR7 Gene

Unigene Clusters for UBR7 Gene

Ubiquitin protein ligase E3 component n-recognin 7 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBR7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1:
SP2: -
SP3: -

Relevant External Links for UBR7 Gene

GeneLoc Exon Structure for
UBR7
ECgene alternative splicing isoforms for
UBR7

Expression for UBR7 Gene

mRNA expression in normal human tissues for UBR7 Gene

Protein differential expression in normal tissues from HIPED for UBR7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.8), Blymphocyte (11.8), Testis (9.8), and Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBR7 Gene



SOURCE GeneReport for Unigene cluster for UBR7 Gene Hs.648806

mRNA Expression by UniProt/SwissProt for UBR7 Gene

Q8N806-UBR7_HUMAN
Tissue specificity: Expressed in sperm (at protein level).
genes like me logo Genes that share expression patterns with UBR7: view

Protein tissue co-expression partners for UBR7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UBR7 Gene

Orthologs for UBR7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBR7 36
  • 100 (a)
OneToOne
UBR7 35
  • 99.69 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia UBR7 36
  • 91 (a)
OneToMany
UBR7 35
  • 91.14 (n)
  • 90.82 (a)
dog
(Canis familiaris)
Mammalia UBR7 35
  • 91.22 (n)
  • 91.53 (a)
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ubr7 16
Ubr7 36
  • 87 (a)
OneToMany
Ubr7 35
  • 86.12 (n)
  • 86.82 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ubr7 35
  • 87.06 (n)
  • 87.53 (a)
chicken
(Gallus gallus)
Aves UBR7 36
  • 72 (a)
OneToMany
UBR7 35
  • 73.17 (n)
  • 75.25 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC398523 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ubr7 35
  • 67.25 (n)
  • 67.83 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.503 35
ubr7 35
  • 61.83 (n)
  • 61.29 (a)
ubr7 36
  • 58 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009512 35
  • 49.44 (n)
  • 42.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15141 36
  • 38 (a)
OneToMany
CG15141 35
  • 50.76 (n)
  • 44.29 (a)
worm
(Caenorhabditis elegans)
Secernentea T22C1.1 36
  • 30 (a)
OneToMany
T22C1.1 35
  • 48.26 (n)
  • 38.43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G23860 35
  • 52.33 (n)
  • 41.37 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.6152 35
rice
(Oryza sativa)
Liliopsida Os06g0529800 35
  • 51.12 (n)
  • 41.49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.821 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for UBR7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBR7 Gene

ENSEMBL:
Gene Tree for UBR7 (if available)
TreeFam:
Gene Tree for UBR7 (if available)

Paralogs for UBR7 Gene

Paralogs for UBR7 Gene

(1) SIMAP similar genes for UBR7 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with UBR7: view

Variants for UBR7 Gene

Sequence variations from dbSNP and Humsavar for UBR7 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1263397 -- 93,216,243(+) GTTTC(A/G)CCATG intron-variant
rs1263398 -- 93,217,313(+) tgagc(C/T)accat intron-variant
rs1152435 -- 93,218,875(+) CATGG(G/T)TAAAC intron-variant
rs1152436 -- 93,219,835(+) CTGGG(C/T)GTGGT intron-variant
rs1152437 -- 93,221,109(+) ccccc(C/G)caatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBR7 Gene

Variant ID Type Subtype PubMed ID
nsv902205 CNV Loss 21882294
nsv516487 CNV Loss 19592680

Variation tolerance for UBR7 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBR7 Gene

HapMap Linkage Disequilibrium report
UBR7
Human Gene Mutation Database (HGMD)
UBR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBR7 Gene

Disorders for UBR7 Gene

Relevant External Links for UBR7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBR7

No disorders were found for UBR7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBR7 Gene

Publications for UBR7 Gene

  1. Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa. (PMID: 24664117) Zimmerman S.W. … Sutovsky P. (Cell Tissue Res. 2014) 3 4 67
  2. Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway. (PMID: 18162545) Lee M.J. … Kwon Y.T. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates. (PMID: 24811749) Besche H.C. … Goldberg A.L. (EMBO J. 2014) 3

Products for UBR7 Gene

Sources for UBR7 Gene

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