UBR5 Gene
protein-coding GIFtS: 61
GCID: GC08M103265
|
|
ubiquitin protein ligase E3 component n-recognin 5(Previous names: E3 ubiquitin protein ligase, HECT domain containing, 1...)
(Previous symbol: EDD1)
| |
Aliases
for UBR5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Protein Ligase E3 Component N-Recognin 51 2 | | E3 Ubiquitin-Protein Ligase, HECT Domain-Containing 12 3 | | EDD11 2 3 5 | | HHYD1 | | HYD1 2 3 5 | | E3 Identified By Differential Display2 | | EDD1 2 3 | | E3 Ubiquitin-Protein Ligase UBR52 | | KIAA08961 3 5 | | Progestin Induced Protein2 | | DD51 2 | | Ubiquitin-Protein Ligase2 | | E3 Ubiquitin Protein Ligase, HECT Domain Containing, 11 2 | | EC 6.3.2.-3 | | Hyperplastic Discs Protein Homolog2 3 | | EC 6.3.28 | | Progestin-Induced Protein2 3 | | |
Export aliases for UBR5 gene to outside databasesPrevious GC identifers: GC08M103336 GC08M098464 |
Summaries
for UBR5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBR5:
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family.The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediatedproteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This genepotentially has a role in regulation of cell proliferation or differentiation. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: UBR5_HUMAN, O95071Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteinsbearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to theirubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation ofmRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumorsuppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays anessential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damageresponse by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading ofubiquitinated chromatin at damaged chromosomes
Gene Wiki entry for UBR5
|
Genomic Views
for UBR5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBR5 gene promoter:
CUTL1 POU6F1 (c2) GATA-1 CREB N-Myc IRF-2 FOXO4 deltaCREB Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBR5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBR5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q22 Ensembl cytogenetic band: 8q22.3 HGNC cytogenetic band: 8q22UBR5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M103265: view genomic region
(about GC identifiers)
Start:
|
103,264,501 bp from pter |
End:
|
103,425,069 bp from pter |
Size:
|
160,569 bases |
Orientation:
|
minus strand |
|
Proteins
for UBR5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBR5_HUMAN, O95071 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase UBR5 Size: 2799 amino acids; 309352 Da
Subunit: Binds TOPBP1. Associates with CDK9 and TFIIS/TCEA1 and forms a transcription regulatory complex made of CDK9,RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruitingtheir promoters. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP proteins (EDVPcomplex). Interacts directly with DYRK2
Subcellular location: Nucleus
Miscellaneous: A cysteine residue is required for ubiquitin-thioester formation
Sequence caution: Sequence=BAA74919.3; Type=Erroneous initiation;
3 PDB 3D structures from  and Proteopedia  for UBR5:1I2T (3D)
2QHO (3D)
3PT3 (3D)
Secondary accessions: B2RP24 O94970 Q9NPL3Explore the universe of human proteins at neXtProt for UBR5: NX_O95071
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95071
4/6 DME Specific Peptides for UBR5 (O95071) (see all 6)
UBR5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056986.2
ENSEMBL proteins: ENSP00000429084 ENSP00000220959 ENSP00000428693 ENSP00000427819 ENSP00000428062 ENSP00000429127 ENSP00000428138
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
UBR5 for ontologies About GeneDecksing
UBR5 Antibody Products:
Assay Products for UBR5: |
Protein
Domains /
Families
for UBR5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBR5 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O95071ProtoNet protein and cluster: O95071 3 Blocks protein families: IPB000449 Ubiquitin-associated domain IPB000569 HECT domain (Ubiquitin-protein ligase) IPB003126 Zn-finger (putative)
UniProtKB/Swiss-Prot: UBR5_HUMAN, O95071Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domainSimilarity: Contains 1 PABC domainSimilarity: Contains 1 UBR-type zinc finger |
Function
for UBR5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBR5_HUMAN, O95071Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteinsbearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to theirubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation ofmRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumorsuppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays anessential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damageresponse by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading ofubiquitinated chromatin at damaged chromosomesEnzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBR5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBR5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBR5 (NM_015902) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBR5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBR5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBR5 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
UBR5 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for UBR5:
Animal Models:
8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ubr5):
UBR5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for UBR5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein Stability | | | 2 | Tryptophan metabolism | | | 3 | Antigen processing: Ubiquitination & Proteasome degradation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for UBR5
1  BioSystems Pathway for UBR5
1 
Kegg Pathway (Kegg details for UBR5):
UniProtKB/Swiss-Prot: UBR5_HUMAN, O95071Pathway: Protein modification; protein ubiquitination
UBR5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBR5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/67 Interacting proteins for UBR5 (O950712, 3 ENSP000002209594) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
UBR5 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBR5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
UBR5 for compounds About GeneDecksing
 Browse Tocris compounds for UBR5
4 HMDB Compounds for UBR5 About this table
1 Novoseek chemical compound relationship for UBR5 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| adenylate |
44.2 |
2 |
11287654 (1), 16554297 (1) |
Search CenterWatch for drugs/clinical trials and news about UBR5
|
Transcripts
for UBR5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBR5 gene: NM_015902.5 Unigene Cluster for UBR5: Ubiquitin protein ligase E3 component n-recognin 5 Hs.492445 [show with all ESTs]Unigene Representative Sequence: NM_01590214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000522784(uc003ykq.3) ENST00000520539(uc003ykr.2 uc003yks.2)
ENST00000220959 ENST00000517465 ENST00000518205 ENST00000521922 ENST00000521767
ENST00000521312 ENST00000521566 ENST00000519528 ENST00000520898 ENST00000519365
ENST00000518145 ENST00000522327
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBR5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBR5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBR5 (NM_015902) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBR5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBR5 |
Additional cDNA sequence: AB020703.3 AF006010.2 AF090904.1 AK002172.1 AK095151.1 AK124995.1 AL833555.1 BC037843.1 BC044598.1 BC053948.1 BC137234.1 BC151231.1 U95000.1 24/25 DOTS entries (see all 25): DT.443859 DT.95311540 DT.95236792 DT.100686108 DT.120644164 DT.100791494 DT.100791502 DT.100791504 DT.439387 DT.120644153 DT.95311536 DT.100667537 DT.433203 DT.91764762 DT.99959733 DT.120644174 DT.120644239 DT.75101365 DT.91764758 DT.91832311 DT.95235827 DT.95251056 DT.40193997 DT.95263369 24/343 AceView cDNA sequences (see all 343): BP364256 AW276321 BM827032 AA884211 NM_015902 AI744543 BU674324 BX478158 BG678652 BQ716376 AA055867 BQ772112 BF968973 AA449255 BG286817 CB145606 W95811 BP346014 BU195000 BU740706 F07961 AK002172 BF724803 BQ017048
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for UBR5 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37 | ^ | 38 | ^ | 39 | ^ | 40 | ^ | 41 | ^ | 42 | ^ | 43 | ^ | 44 | ^ | 45 | ^ | 46 | ^ | 47 | ^ | 48 | ^ | 49 | ^ | 50 | ^ | 51 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 52a | · | 52b | · | 52c | ^ | 53 | ^ | 54a | · | 54b | ^ | 55 | ^ | 56 | ^ | 57 | ^ | 58 | ^ | 59 | ^ | 60a | · | 60b | · | 60c |
|---|
|
| SP1: | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UBR5
|
Expression
for UBR5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBR5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See UBR5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBR5
SOURCE GeneReport for Unigene cluster: Hs.492445
UniProtKB/Swiss-Prot: UBR5_HUMAN, O95071Tissue specificity: Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary andkidney
SABiosciences Expression via Pathway-Focused PCR Array including UBR5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBR5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBR5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBR5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBR5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBR5 |
Orthologs
for UBR5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBR5 gene from 8/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
UBR51 |
ubiquitin protein ligase E3 component n-recognin 5 |
85.18(n)
97.91(a) |
|
420252 XM_003640847.1 XP_003640895.1 |
lizard
(Anolis carolinensis) |
Reptilia |
UBR56TRIP126 |
-- |
97(a)3(a) |
1 ↔ 1possible ortholog |
4(13958200-14005310) 3(22445613-22490489) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.86062 |
Xenopus laevis transcribed sequence with strong similarity more |
80.48(n) |
|
CA793015.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufa16c122 |
Transcribed sequence with strong similarity to protein more |
76.41(n) |
|
CK026475.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
hyd1 |
hyperplastic discs |
50.49(n)
46.78(a) |
|
41181 NM_079572.3 NP_524296.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
F36A2.136 |
-- |
23(a) |
1 ↔ 1 |
I(8828037-8838712) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
UPL56 |
E3 ubiquitin-protein ligase UPL5 |
9(a) |
1 ↔ 1 |
4(7445362-7449086) |
rice
(Oryza sativa) |
Liliopsida |
-- |
HECT-domain domain containing protein, expressed |
9(a) |
1 ↔ 1 |
9(18686739-18693227) |
ENSEMBL Gene Tree for UBR5 (if available)
TreeFam Gene Tree for UBR5 (if available) |
Paralogs
for UBR5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBR5 gene
- HUWE12
4 SIMAP similar genes for UBR5 using alignment to 9 protein entries: UBR5_HUMAN (see all proteins):PABPC1 HACE1 KIAA0317 FBXO11
UBR5 for paralogs About GeneDecksing
|
Genomic Variants
for UBR5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBR5 (103264501 - 103425069 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for UBR5
1 CNV: 7659
1 Indel: 65214
Human Gene Mutation Database (HGMD): UBR5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBR5 |
|
Disorders
/ Diseases
for UBR5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBR5 for disorders About GeneDecksing
OMIM gene information: 608413
OMIM disorders: --
8  diseases for UBR5: About MalaCardsdna topoisomerase ii aortic valve insufficiency acneiform dermatitis cerebrovascular accident
epithelial ovarian cancer echinococcosis ovarian cancer breast cancer
3 diseases from the University of Copenhagen DISEASES database for UBR5:Echinococcosis Acneiform dermatitis Eating disorder 2 Novoseek disease relationships for UBR5 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| breast cancer |
17.7 |
4 |
10030672 (1), 12902990 (1) |
| cancer |
0 |
8 |
12902990 (3), 10030672 (1) |
Export disorders for UBR5 gene to outside databases
|
Publications
for UBR5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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|
PubMed articles for UBR5 gene, integrated from 9 sources (see all 81):
(articles sorted by number of sources associating them with UBR5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs. (PubMed id 10030672)1, 2, 3, 9 Callaghan M.J.... Watts C.K.W. (1998)
- X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein. (PubMed id 11287654)1, 2, 9 Deo R.C.... Burley S.K. (2001)
- TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes. (PubMed id 22884692)1, 2 Gudjonsson T.... Lukas C. (2012)
- Acetylation regulates gluconeogenesis by promoting PE PCK1 degradation via recruiting the UBR5 ubiquitin ligase. (PubMed id 21726808)1, 2 Jiang W....Zhao S. (2011)
- Transcription factor IIS cooperates with the E3 ligas e UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongatio n factor B. (PubMed id 21127351)1, 2 Cojocaru M....Coulombe B. (2011)
- Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. (PubMed id 19287380)1, 2 Maddika S. and Chen J. (2009)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. (PubMed id 16055722)1, 3 Tasaki T....Kwon Y.T. (2005)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response. (PubMed id 11714696)1, 2 Honda Y.... Nakao M. (2002)
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External Searches for UBR5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing UBR5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing UBR5 gene
(According to HUGE)
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| |
Specialized Databases showing UBR5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| PharmGKB entry for UBR5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBR5 gene:
Search GeneIP for patents involving UBR5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBR5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | OriGene Antibodies for UBR5 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBR5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBR5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBR5 | | OriGene 3'-UTR Clone for UBR5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBR5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBR5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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