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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBR4 Gene

protein-coding   GIFtS: 58
GCID: GC01M019401

Ubiquitin Protein Ligase E3 Component N-Recognin 4

(Previous names: zinc finger, UBR1 type 1)
(Previous symbol: ZUBR1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Protein Ligase E3 Component N-Recognin 41 2     Zinc Finger, UBR1 Type 11
ZUBR11 2 3 5     E3 Ubiquitin-Protein Ligase UBR42
RBAF6002 3 5     Retinoblastoma-Associated Factor 600-Like Protein2
Retinoblastoma-Associated Factor Of 600 KDa2 3     600 KDa Retinoblastoma Protein-Associated Factor3
Zinc Finger UBR1-Type Protein 12 3     EC 6.3.2.-3
N-recognin-42 3     KIAA04623
p6002 3     EC 6.3.28
KIAA13073 5     

External Ids:    HGNC: 303131   Entrez Gene: 233522   Ensembl: ENSG000001274817   OMIM: 6098905   UniProtKB: Q5T4S73   

Export aliases for UBR4 gene to outside databases

Previous GC identifers: GC01M019274 GC01M017647


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBR4 Gene:
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the
retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded
protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the
nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. (provided by
RefSeq, Aug 2010)

GeneCards Summary for UBR4 Gene: 
UBR4 (ubiquitin protein ligase E3 component n-recognin 4) is a protein-coding gene. Diseases associated with UBR4 include retinoblastoma, and papilloma, and among its related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and calmodulin binding.

UniProtKB/Swiss-Prot: UBR4_HUMAN, Q5T4S7
Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to
proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to
their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in
membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in
activation of FAK in response to cell-matrix interactions

Gene Wiki entry for UBR4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBR4 gene promoter:
         c-Fos   STAT1   AML1a   AP-1   STAT1beta   STAT1alpha   HEN1   POU2F1a   SEF-1 (1)   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBR4 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBR4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

UBR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBR4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M019401:  view genomic region     (about GC identifiers)

Start:
19,401,000 bp from pter      End:
19,536,770 bp from pter
Size:
135,771 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBR4_HUMAN, Q5T4S7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase UBR4  
Size: 5183 amino acids; 573841 Da
Subunit: Interacts with RB1 and calmodulin. Interacts with protein E7 from papilloma virus HPV-16, HPV-6B and
HPV-11
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Cytoplasm, cytoskeleton.
Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility
Sequence caution: Sequence=CAD43719.1; Type=Erroneous initiation; Sequence=CAI19271.1; Type=Erroneous gene model
prediction;
Secondary accessions: A8MPT2 A8MQ33 A8MQB1 O60646 O75050 Q4QRK5 Q5T4S8 Q5T4S9 Q5TBN8 Q5TBP2
Q6DKH8 Q6P4A4 Q7L8P7 Q8IXJ4 Q8TDN5 Q8WV67 Q9HA46 Q9P2N9 Q9UG82
Alternative splicing: 6 isoforms:  Q5T4S7-1   Q5T4S7-2   Q5T4S7-3   Q5T4S7-4   Q5T4S7-5   Q5T4S7-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBR4: NX_Q5T4S7

Explore proteomics data for UBR4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T4S7

  • 2 DME Specific Peptides for UBR4 (Q5T4S7)
     FFCDCGA  PCLVCNNPEV 

    UBR4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBR4 Protein Expression
    REFSEQ proteins: NP_065816.2  
    ENSEMBL proteins: 
     ENSP00000364403   ENSP00000364373   ENSP00000364372   ENSP00000364366   ENSP00000395313  
     ENSP00000404897   ENSP00000364416   ENSP00000364365   ENSP00000364374   ENSP00000444070  
     ENSP00000394173  
    Reactome Protein details: Q5T4S7
    Human Recombinant Protein Products for UBR4: 
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    Novus Biologicals UBR4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBR4 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0016021integral to membrane IEA--

    UBR4 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for UBR4 

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    Cloud-Clone Corp. ELISAs for UBR4 
    Cloud-Clone Corp. CLIAs for UBR4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBR: Ubiquitin protein ligase E3 component n-recognins

    2 InterPro protein domains:
     IPR025704 E3_Ub_ligase_UBR4
     IPR003126 Znf_N-recognin

    Graphical View of Domain Structure for InterPro Entry Q5T4S7

    ProtoNet protein and cluster: Q5T4S7

    1 Blocks protein domain: IPB003126 Zn-finger (putative)

    UniProtKB/Swiss-Prot: UBR4_HUMAN, Q5T4S7
    Similarity: Belongs to the UBR4 family
    Similarity: Contains 1 UBR-type zinc finger


    UBR4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBR4_HUMAN, Q5T4S7
    Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to
    proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to
    their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in
    membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in
    activation of FAK in response to cell-matrix interactions

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005488binding ----
    GO:0005515protein binding IPI16061792
    GO:0005516calmodulin binding IEA--
    GO:0008270zinc ion binding IEA--
         
    UBR4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UBR4:
     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ubr4):
     cardiovascular system  cellular  embryogenesis  mortality/aging 

    UBR4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ubr4tm1.1Ytkw for UBR4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBR4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBR4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBR4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBR4 

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate UBR4:
    hsa-miR-576-3p hsa-miR-577 hsa-miR-103b hsa-miR-26a hsa-miR-26b hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidUBR4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBR4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBR4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Viral carcinogenesis
    Viral carcinogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for UBR4
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for UBR4):
        Viral carcinogenesis

    UniProtKB/Swiss-Prot: UBR4_HUMAN, Q5T4S7
    Pathway: Protein modification; protein ubiquitination


    UBR4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBR4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/28 Interacting proteins for UBR4 (Q5T4S71, 2, 3 ENSP000003644034) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCRS1Q96EZ81, 3, ENSP000003496404EBI-1995940,EBI-348259 I2D: score=2 STRING: ENSP00000349640
    SRGNP101242, 3, ENSP000002424654MINT-8272197 I2D: score=2 STRING: ENSP00000242465
    PRPF40AO754002, 3MINT-61852 I2D: score=3 
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA--

    UBR4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBR4

    4 HMDB Compounds for UBR4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about UBR4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBR4 gene: 
    NM_020765.2  

    Unigene Clusters for UBR4:

    Ubiquitin protein ligase E3 component n-recognin 4
    Hs.148078  [show with all ESTs], Hs.649405  [show with all ESTs]
    Unigene Representative Sequences: NM_020765, AK024105
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000375254(uc001bbi.3) ENST00000375225(uc001bbf.3) ENST00000375224(uc001bbg.3)
    ENST00000459947 ENST00000486515 ENST00000492606 ENST00000467272 ENST00000483922
    ENST00000494503 ENST00000466969 ENST00000375218(uc001bbj.1) ENST00000425413
    ENST00000417040 ENST00000475973 ENST00000465036 ENST00000419533(uc001bbl.1 uc001bbm.1)
    ENST00000497018 ENST00000375267(uc009vph.3)
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate UBR4:
    hsa-miR-576-3p hsa-miR-577 hsa-miR-103b hsa-miR-26a hsa-miR-26b hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidUBR4 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: UBR4 (NM_020765)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UBR4
    Primer
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    Additional mRNA sequence: AK024105.1 

    24/43 DOTS entries (see all 43):

    DT.423572  DT.97858115  DT.455169  DT.100826626  DT.91769709  DT.92418388  DT.100826630  DT.91769707 
    DT.101961269  DT.92353227  DT.95367094  DT.102835166  DT.121394597  DT.121394640  DT.121394680  DT.91812628 
    DT.121394550  DT.40204945  DT.91769704  DT.97833323  DT.100038666  DT.403256  DT.95163020  DT.97857452 

    24/582 AceView cDNA sequences (see all 582):

    BQ276386 BQ718138 AI923342 BF868870 BQ574710 BX460563 AX747516 BX643039 
    BF758570 NM_020765 C01355 AI348174 AB007931 AW136037 CA427747 BQ069232 
    AL049972 CA426972 AU140665 CR619441 AA442961 AF348492 AI033195 CD514217 

    GeneLoc Exon Structure

    5/48 Alternative Splicing Database (ASD) splice patterns (SP) for UBR4 (see all 48)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b ^ 38 ^ 39 ^ 40 ^ 41 ^ 42a · 42b ^ 43 ^ 44a · 44b · 44c ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 44d ^ 45a · 45b ^ 46a · 46b ^ 47a · 47b ^ 48a · 48b ^ 49 ^ 50a · 50b ^ 51a · 51b ^ 52 ^ 53a · 53b ^ 54 ^ 55 ^ 56a · 56b ^ 57 ^ 58 ^ 59a · 59b · 59c ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 59d ^ 60a · 60b · 60c ^ 61 ^ 62a · 62b ^ 63a · 63b ^ 64a · 64b ^ 65a · 65b · 65c ^ 66 ^ 67a · 67b ^ 68a · 68b ^ 69a · 69b · 69c ^ 70a · 70b ^ 71 ^ 72a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 72b ^ 73a · 73b ^ 74a · 74b ^ 75a · 75b · 75c ^ 76a · 76b ^ 77a · 77b ^ 78a · 78b · 78c ^ 79a · 79b ^ 80a · 80b ^ 81 ^ 82 ^ 83 ^ 84a · 84b ^ 85a · 85b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                      -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                      -                     

    ExUns: 86 ^ 87a · 87b ^ 88a · 88b ^ 89 ^ 90a · 90b ^ 91a · 91b ^ 92 ^ 93 ^ 94 ^ 95a · 95b ^ 96 ^ 97a · 97b ^ 98 ^ 99 ^ 100a · 100b ^ 101 ^ 102a · 102b ^ 103a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                      -                                                           -     -   
    SP3:  -                                                                                                                                                         
    SP4:                                                                                                                                                            
    SP5:  -                                                                                                                                                         

    ExUns: 103b · 103c ^ 104a · 104b ^ 105 ^
    SP1:                              
    SP2:              -     -         
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for UBR4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBR4 expression in normal human tissues (normalized intensities)      UBR4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTGTCCCG
    UBR4 Expression
    About this image


    UBR4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Thalamus
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Eye (Sensory Organs)
             Retina
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See UBR4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBR4

    SOURCE GeneReport for Unigene clusters: Hs.148078 Hs.649405
        SABiosciences Expression via Pathway-Focused PCR Array including UBR4: 
              Ubiquitin Ligases in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBR4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UBR4 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubr41 , 5 ubiquitin protein ligase E3 component n-recognin 41, 5 89.2(n)1
    96.95(a)1
      4 (70.66 cM)5
    691161  NM_001160319.11  NP_001153791.11 
     1393526095 
    chicken
    (Gallus gallus)
    Aves UBR41 ubiquitin protein ligase E3 component n-recognin 4 81.16(n)
    93.18(a)
      419469  XM_417626.3  XP_417626.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    UBR46
    (see all 4)
    Uncharacterized protein
    (see all 4)
    92(a)
    90(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    AAWZ02038818(708-9845)
    AAWZ02037712(967-14863)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.33762 Xenopus laevis transcribed sequence with moderate similarity to protein pirT00076 (H.sapiens) T00076 hypothetical protein KIAA0462 - human (fragment) less 80.73(n)    CD301580.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nrp12 neuropilin 1 78.98(n)    BG737483.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta poe1 purity of essence 50.02(n)
    42.55(a)
      46243  NM_057638.3  NP_476986.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C44E4.11 Protein C44E4.1 41.17(n)
    28.9(a)
      172068  NM_059006.1  NP_491407.1 


    ENSEMBL Gene Tree for UBR4 (if available)
    TreeFam Gene Tree for UBR4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3241 SNPs in UBR4 are shown (see all 3241)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0321954
    A melanoma patient4--see VAR_0321952 G R mis40--------
    VAR_0355404
    A breast cancer sample4--see VAR_0355402 R H mis40--------
    rs1169026441,2
    C,F--17659435(+) AAGTCA/CGTCGG 1 -- int11Minor allele frequency- C:0.07EA 120
    rs1464703541,2
    --17659460(+) CCTGCA/GAAGAG 1 -- int10--------
    rs615478161,2
    C--17696522(+) AAAAA-/A/AA  
            
    CAAAG
    1 -- int11NA 2
    rs784711781,2
    --17702826(+) TGAAAA/TTTAAT 1 -- int10--------
    rs679873321,2
    C--17718553(+) AACCACT/-GAGAC 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2016109341,2
    C--17744267(+) AAAAAA/CCTGTT 1 -- int10--------
    rs2016109151,2
    --17763359(+) AAAAA-/TATATATA 1 -- int10--------
    rs672329761,2
    C--19408294(+) CCTGGC/-CCCCA 1 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for UBR4 (19401000 - 19536770 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UBR4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5298CNV Insertion18451855
    nsv508980CNV Insertion20534489
    nsv834347CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UBR4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609890    OMIM disorders: --

    3 diseases for UBR4:    About MalaCards
    retinoblastoma    papilloma    melanoma


    UBR4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UBR4
    Human Genome Epidemiology (HuGE) Navigator: UBR4 (1 document)

    Export disorders for UBR4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBR4 gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with UBR4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600. (PubMed id 16061792)1, 2, 9 Huh K.-W.... Muenger K. (2005)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. p600, a unique protein required for membrane morphogenesis and cell survival. (PubMed id 16214886)1, 2 Nakatani Y.... Herlitz A.M. (2005)
    6. The response of autologous T cells to a human melanoma is dominated by mutated neoantigens. (PubMed id 16247014)1, 2 Lennerz V.... Woelfel T. (2005)
    7. A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. (PubMed id 16055722)1, 3 Tasaki T....Kwon Y.T. (2005)
    8. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (1997)
    9. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    10. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23352 HGNC: 30313 AceView: RBAF600 Ensembl:ENSG00000127481 euGenes: HUgn23352
    ECgene: UBR4 Kegg: 23352 H-InvDB: UBR4

    (According to HUGE)
    About This Section
    HUGE: KIAA1307 KIAA0462

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBR4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBR4 gene:
    Search GeneIP for patents involving UBR4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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