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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UBR4 Gene

protein-coding GIFtS: 54
GCID: GC01M019401

ubiquitin protein ligase E3 component n-recognin 4

(Previous names: zinc finger, UBR1 type 1 )
(Previous symbol: ZUBR1)

Explore 3 diseases affiliated with
UBR4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ubiquitin Protein Ligase E3 Component N-Recognin 4¹ ²		P600¹
RBAF600¹ ² ³ ⁵		Zinc Finger, UBR1 Type 1¹
ZUBR1¹ ² ³ ⁵		E3 Ubiquitin-Protein Ligase UBR4²
KIAA1307¹ ³ ⁵		Retinoblastoma-Associated Factor 600-Like Protein²
KIAA0462¹ ³		600 KDa Retinoblastoma Protein-Associated Factor³
Retinoblastoma-Associated Factor Of 600 KDa² ³		EC 6.3.2.-³
Zinc Finger UBR1-Type Protein 1² ³		EC 6.3.2⁸
N-Recognin-4¹

External Ids:	HGNC: 30313¹	Entrez Gene: 23352²	Ensembl: ENSG00000127481⁷	OMIM: 609890⁵	UniProtKB: Q5T4S7³

Export aliases for UBR4 gene to outside databases

Previous GC identifers: GC01M019274 GC01M017647

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBR4:

The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated

protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a

cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein

is a target of the human papillomavirus type 16 E7 oncoprotein. (provided by RefSeq, Aug 2010)

UniProtKB/Swiss-Prot: UBR4_HUMAN, Q5T4S7

Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins

bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their

ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane

morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of

FAK in response to cell-matrix interactions

Gene Wiki entry for UBR4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UBR4 gene promoter:
c-Fos STAT1 AML1a AP-1 STAT1beta STAT1alpha HEN1 POU2F1a SEF-1 (1) c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBR4 promoter sequence

Search SABiosciences Chromatin IP Primers for UBR4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBR4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13

UBR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBR4 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M019401: view genomic region (about GC identifiers)

Start:	19,401,000 bp from pter	End:	19,536,770 bp from pter
Size:	135,771 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UBR4_HUMAN, Q5T4S7 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase UBR4

Size: 5183 amino acids; 573841 Da

Subunit: Interacts with RB1 and calmodulin. Interacts with protein E7 from papilloma virus HPV-16, HPV-6B and HPV-11

Subcellular location: Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.

Note=Concentrates at the leading edge of membrane structures involved in actin motility

Sequence caution: Sequence=CAD43719.1; Type=Erroneous initiation; Sequence=CAI19271.1; Type=Erroneous gene model

prediction;

Secondary accessions: A8MPT2 A8MQ33 A8MQB1 O60646 O75050 Q4QRK5 Q5T4S8 Q5T4S9 Q5TBN8 Q5TBP2 Q6DKH8

Q6P4A4 Q7L8P7 Q8IXJ4 Q8TDN5 Q8WV67 Q9HA46 Q9P2N9 Q9UG82

Alternative splicing: 6 isoforms: Q5T4S7-1 Q5T4S7-2 Q5T4S7-3 Q5T4S7-4 Q5T4S7-5 Q5T4S7-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBR4: NX_Q5T4S7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5T4S7

2 DME Specific Peptides for UBR4 (Q5T4S7)

FFCDCGA

PCLVCNNPEV

UBR4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_065816.2

ENSEMBL proteins:

ENSP00000364403 ENSP00000364373 ENSP00000364372 ENSP00000364366 ENSP00000395313

ENSP00000404897 ENSP00000391875 ENSP00000364416 ENSP00000364365 ENSP00000364374

ENSP00000444070 ENSP00000394173

Reactome Protein details: Q5T4S7
Human Recombinant Protein Products:

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	Novus Biologicals UBR4 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for UBR4

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--
GO:0016021	integral to membrane	IEA	--

UBR4 for ontologies About GeneDecksing

UBR4 Antibody Products:

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Assay Products for UBR4:

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	Uscn ELISAs and CLIAs for UBR4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UBR4 for domains About GeneDecksing

2 InterPro domains/families:

IPR025704 E3_Ub_ligase_UBR4

IPR003126 Znf_N-recognin

Graphical View of Domain Structure for InterPro Entry Q5T4S7

ProtoNet protein and cluster: Q5T4S7

1 Blocks protein family: IPB003126 Zn-finger (putative)

UniProtKB/Swiss-Prot: UBR4_HUMAN, Q5T4S7

Similarity: Belongs to the UBR4 family

Similarity: Contains 1 UBR-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: UBR4_HUMAN, Q5T4S7

Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins

bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their

ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane

morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of

FAK in response to cell-matrix interactions

Enzyme Numbers (IUBMB): EC 6.3.2.-¹ EC 6.3.2²

miRNA Products:		OriGene 3'-UTR Clone: UBR4 Browse MicroRNA Expression Plasmids
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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate UBR4:
		hsa-miR-576-3p hsa-miR-577 hsa-miR-103b hsa-miR-26a hsa-miR-26b hsa-miR-1297
		SwitchGear 3'UTR luciferase reporter plasmid: UBR4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for UBR4
		Search LifeMap BioReagents cell lines for UBR4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBR4

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IEA	--
GO:0005516	calmodulin binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0016874	ligase activity	--	--

UBR4 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for UBR4:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for UBR4

	Antigen processing: Ubiquitination & Proteasome degradation
	Polyubiquitination of substrate
	Adaptive Immune System
	Class I MHC mediated antigen processing & presentation
	Immune System

UniProtKB/Swiss-Prot: UBR4_HUMAN, Q5T4S7

Pathway: Protein modification; protein ubiquitination

UBR4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for UBR4

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/28 Interacting proteins for UBR4 (Q5T4S7^{1, 2, 3} ENSP00000364403⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MCRS1	Q96EZ8¹^,³, ENSP00000349640⁴	EBI-1995940,EBI-348259 I2D: score=2 STRING: ENSP00000349640
SRGN	P10124²^,³, ENSP00000242465⁴	MINT-8272197 I2D: score=2 STRING: ENSP00000242465
PRPF40A	O75400²^,³	MINT-61852 I2D: score=3
CALM1	P62158³	I2D: score=1
CALM2	P62158³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019048	virus-host interaction	IEA	--
GO:0044419	interspecies interaction between organisms	--	--

UBR4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UBR4

4 HMDB Compounds for UBR4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

Search CenterWatch for drugs/clinical trials and news about UBR4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UBR4 gene:

NM_020765.2

Unigene Clusters for UBR4:

Ubiquitin protein ligase E3 component n-recognin 4

Hs.148078 [show with all ESTs], Hs.649405 [show with all ESTs]

Unigene Representative Sequences: NM_020765, AK024105

18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000375254(uc001bbi.3) ENST00000375225(uc001bbf.3) ENST00000375224(uc001bbg.3)

ENST00000459947 ENST00000486515 ENST00000492606 ENST00000467272 ENST00000483922

ENST00000494503 ENST00000466969 ENST00000375218(uc001bbj.1) ENST00000425413

ENST00000417040 ENST00000475973 ENST00000465036 ENST00000419533(uc001bbl.1 uc001bbm.1)

ENST00000497018 ENST00000375267(uc009vph.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBR4
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate UBR4:
		hsa-miR-576-3p hsa-miR-577 hsa-miR-103b hsa-miR-26a hsa-miR-26b hsa-miR-1297
		SwitchGear 3'UTR luciferase reporter plasmid: UBR4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: UBR4 (NM_020765)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBR4

Additional cDNA sequence: AK024105.1

24/43 DOTS entries (see all 43):

DT.423572 DT.97858115 DT.455169 DT.100826626 DT.91769709 DT.92418388 DT.100826630 DT.91769707

DT.101961269 DT.92353227 DT.95367094 DT.102835166 DT.121394597 DT.121394640 DT.121394680 DT.91812628

DT.121394550 DT.40204945 DT.91769704 DT.97833323 DT.100038666 DT.403256 DT.95163020 DT.97857452

24/582 AceView cDNA sequences (see all 582):

AI139494 BF769655 BQ276386 BP359954 BU184016 BQ955434 BX460563 AL707233

AA374653 AA496940 AI018651 BP344471 BC073905 BQ574710 AI056779 BM454370

BU625663 AA442961 BQ943700 AI937477 CD366815 BF769993 AI904000 BU196698

GeneLoc Exon Structure

5/48 Alternative Splicing Database (ASD) splice patterns (SP) for UBR4 (see all 48) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35	^	36	^	37a	·	37b	^	38	^	39	^	40	^	41	^	42a	·	42b	^	43	^	44a	·	44b	·	44c	·
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	44d	^	45a	·	45b	^	46a	·	46b	^	47a	·	47b	^	48a	·	48b	^	49	^	50a	·	50b	^	51a	·	51b	^	52	^	53a	·	53b	^	54	^	55	^	56a	·	56b	^	57	^	58	^	59a	·	59b	·	59c	·
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	59d	^	60a	·	60b	·	60c	^	61	^	62a	·	62b	^	63a	·	63b	^	64a	·	64b	^	65a	·	65b	·	65c	^	66	^	67a	·	67b	^	68a	·	68b	^	69a	·	69b	·	69c	^	70a	·	70b	^	71	^	72a	·
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	72b	^	73a	·	73b	^	74a	·	74b	^	75a	·	75b	·	75c	^	76a	·	76b	^	77a	·	77b	^	78a	·	78b	·	78c	^	79a	·	79b	^	80a	·	80b	^	81	^	82	^	83	^	84a	·	84b	^	85a	·	85b	^
SP1:
SP2:
SP3:																																													-
SP4:
SP5:																																													-

ExUns:	86	^	87a	·	87b	^	88a	·	88b	^	89	^	90a	·	90b	^	91a	·	91b	^	92	^	93	^	94	^	95a	·	95b	^	96	^	97a	·	97b	^	98	^	99	^	100a	·	100b	^	101	^	102a	·	102b	^	103a	·
SP1:
SP2:																													-																				-		-
SP3:	-
SP4:
SP5:	-

ExUns:	103b	·	103c	^	104a	·	104b	^	105	^
SP1:
SP2:					-		-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for UBR4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UBR4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTTGTCCCG

About this image
See UBR4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBR4

SOURCE GeneReport for Unigene clusters: Hs.148078 Hs.649405

SABiosciences Expression via Pathway-Focused PCR Array including UBR4:

Ubiquitin Ligases in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBR4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBR4 gene from 9/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ubr4^{1 , 5}	ubiquitin protein ligase E3 component n-recognin 4^{1, 5}	89.2(n)¹ 96.95(a)¹		4 (70.66 cM)⁵ 69116¹ NM_001160319.1¹ NP_001153791.1¹ 139352609⁵
chicken (Gallus gallus)	Aves	UBR4¹	ubiquitin protein ligase E3 component n-recognin 4	81.16(n) 93.18(a)		419469 XM_417626.3 XP_417626.3
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	93(a) 92(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	GL344719.1(1019-21046) AAWZ02036952(933-12410)
African clawed frog (Xenopus laevis)	Amphibia	Xl.3376²	Xenopus laevis transcribed sequence with moderate similarity to protein pirT00076 (H.sapiens) T00076 hypothetical protein KIAA0462 - human (fragment) less	80.73(n)		CD301580.1
zebrafish (Danio rerio)	Actinopterygii	nrp1²	neuropilin 1	78.98(n)		BG737483.1
fruit fly (Drosophila melanogaster)	Insecta	poe¹	purity of essence	50.02(n) 42.55(a)		46243 NM_057638.3 NP_476986.1
worm (Caenorhabditis elegans)	Secernentea	C44E4.1¹	Protein C44E4.1	41.17(n) 28.9(a)		172068 NM_059006.1 NP_491407.1
thale cress (Arabidopsis thaliana)	eudicotyledons	LPR1⁶	E3 ubiquitin-protein ligase UBR4	21(a)	1 ↔ 1	3(430984-448489)
rice (Oryza sativa)	Liliopsida	-- --	BIG, putative, expressed	24(a) 21(a)	many → 1 many → 1	9(3585600-3588801) 9(3589118-3606830)

ENSEMBL Gene Tree for UBR4 (if available)
TreeFam Gene Tree for UBR4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116205305^1,2	C,F,	--	17647201(+)	`CATGAG/AANNNN`	1	--	ds500¹		1		NA	120
rs11577000^1,2	C,F,H,	--	17647508(+)	`CAAGGG/AAAACC`	1	--	ds500¹		5		NS EA NA	418
rs55886649^1,2	C	--	17647707(+)	`GCACCA/GCACAC`	1	--	ut3¹		0	--	--	--	--
rs200837355^1,2	C	--	17647742(+)	`AACCCA/CAAGCC`	1	--	ut3¹		0	--	--	--	--
rs41273185^1,2	F,	--	17648005(+)	`CATTCC/TCCCTG`	1	--	int¹		3		WA NA EA	358
rs77961915^1,2		--	17648094(+)	`TGACCG/AGGGAG`	1	--	int¹		1		WA	118
rs16862503^1,2	C,F,H,	--	17648102(+)	`GAGGTA/TGTCAT`	1	--	int¹		11		NA NS EA WA	986
rs79924631^1,2	F,	--	17648292(+)	`CGCTGC/TCTGGC`	1	--	int¹		1		WA	118
rs76570760^1,2	F,	--	17648367(+)	`AGCTCG/CAGCCC`	1	--	int¹		1		WA	118
rs1886024^1,2	C,F,O,H,	--	17648528(-)	`TGCCTC/TGCGTT`	1	--	int¹		16		NA NS EA WA	1852

HapMap Linkage Disequilibrium report for UBR4 (19401000 - 19536770 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBR4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBR4

DNA2.0 Custom Variant and Variant Library Synthesis for UBR4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

UBR4 for disorders           About GeneDecksing

OMIM gene information: 609890    OMIM disorders: --

3 diseases for UBR4:    About MalaCards

retinoblastoma melanoma papilloma

Human Genome Epidemiology (HuGE) Navigator: UBR4 (1 document)

Export disorders for UBR4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for UBR4 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with UBR4)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2, 3} Ota T.... Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2, 3} Nagase T.... Ohara O. (2000)
Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600. (PubMed id 16061792)^{1, 2, 9} Huh K.-W.... Muenger K. (2005)
p600, a unique protein required for membrane morphogenesis and cell survival. (PubMed id 16214886)^{1, 2} Nakatani Y.... Herlitz A.M. (2005)
The response of autologous T cells to a human melanoma is dominated by mutated neoantigens. (PubMed id 16247014)^{1, 2} Lennerz V.... Woelfel T. (2005)
A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. (PubMed id 16055722)^{1, 3} Tasaki T....Kwon Y.T. (2005)
Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)^{1, 2} Seki N.... Ohara O. (1997)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)¹ Naji S....Gerace L. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23352	HGNC: 30313	AceView: RBAF600	Ensembl:ENSG00000127481	euGenes: HUgn23352
ECgene: UBR4	H-InvDB: UBR4

(According to HUGE)
About This Section

HUGE: KIAA1307 KIAA0462

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for UBR4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UBR4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for UBR4 gene:
Search GeneIP for patents involving UBR4

GeneCards and IP:
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ubiquitin protein ligase E3 component n-recognin 4

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ubiquitin protein ligase E3 component n-recognin 4

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