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Aliases for UBR4 Gene

Aliases for UBR4 Gene

  • Ubiquitin Protein Ligase E3 Component N-Recognin 4 2 3 5
  • Retinoblastoma-Associated Factor Of 600 KDa 3 4
  • RING-Type E3 Ubiquitin Transferase UBR4 3 4
  • Zinc Finger UBR1-Type Protein 1 3 4
  • N-Recognin-4 3 4
  • RBAF600 3 4
  • ZUBR1 3 4
  • P600 3 4
  • Retinoblastoma-Associated Factor 600-Like Protein 3
  • 600 KDa Retinoblastoma Protein-Associated Factor 4
  • E3 Ubiquitin-Protein Ligase UBR4 3
  • Zinc Finger, UBR1 Type 1 2
  • EC 2.3.2.27 4
  • KIAA0462 4
  • KIAA1307 4
  • EC 6.3.2 56

External Ids for UBR4 Gene

Previous HGNC Symbols for UBR4 Gene

  • ZUBR1

Previous GeneCards Identifiers for UBR4 Gene

  • GC01M019274
  • GC01M019401
  • GC01M017647

Summaries for UBR4 Gene

Entrez Gene Summary for UBR4 Gene

  • The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

GeneCards Summary for UBR4 Gene

UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Innate Immune System. Gene Ontology (GO) annotations related to this gene include binding and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for UBR4 Gene

  • E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.

Gene Wiki entry for UBR4 Gene

Additional gene information for UBR4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBR4 Gene

Genomics for UBR4 Gene

GeneHancer (GH) Regulatory Elements for UBR4 Gene

Promoters and enhancers for UBR4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I019207 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 574.1 +0.5 528 4.3 MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SP3 NFYC UBR4 LOC101927895 EMC1 MRTO4 PIR60239
GH01I019310 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 26.6 -103.2 -103172 6.7 HDGF ARNT ARID4B SIN3A YBX1 DMAP1 IRF4 POLR2B ZNF213 E2F8 AKR7A2 PQLC2 UBR4 OTUD3 AKR7L EMC1 ENSG00000272084 GC01M019319 GC01M019320
GH01I018901 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.6 +307.5 307467 3.6 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ALDH4A1 UBR4 IFFO2 ENSG00000255275
GH01I019642 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 18.5 -438.3 -438323 11.7 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZNF143 ZNF548 FOS MCM3 NBL1 UBR4 HTR6 MUL1 GC01M019654 MINOS1-NBL1
GH01I018925 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 24.5 +282.3 282335 4.8 HDGF ZNF493 YBX1 GLI4 IRF4 ZNF207 ATF7 FOS RUNX3 YY2 EMC1 UBR4 IFFO2 ENSG00000255275
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBR4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBR4 gene promoter:

Genomic Locations for UBR4 Gene

Genomic Locations for UBR4 Gene
chr1:19,074,506-19,210,319
(GRCh38/hg38)
Size:
135,814 bases
Orientation:
Minus strand
chr1:19,401,000-19,536,770
(GRCh37/hg19)

Genomic View for UBR4 Gene

Genes around UBR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBR4 Gene

Proteins for UBR4 Gene

  • Protein details for UBR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4S7-UBR4_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase UBR4
    Protein Accession:
    Q5T4S7
    Secondary Accessions:
    • A8MPT2
    • A8MQ33
    • A8MQB1
    • O60646
    • O75050
    • Q4QRK5
    • Q5T4S8
    • Q5T4S9
    • Q5TBN8
    • Q5TBP2
    • Q6DKH8
    • Q6P4A4
    • Q7L8P7
    • Q8IXJ4
    • Q8TDN5
    • Q8WV67
    • Q9HA46
    • Q9P2N9
    • Q9UG82

    Protein attributes for UBR4 Gene

    Size:
    5183 amino acids
    Molecular mass:
    573841 Da
    Quaternary structure:
    • Interacts with RB1 and calmodulin. Interacts with protein E7 from papilloma virus HPV-16, HPV-6B and HPV-11.
    SequenceCaution:
    • Sequence=CAD43719.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19271.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UBR4 Gene

neXtProt entry for UBR4 Gene

Selected DME Specific Peptides for UBR4 Gene

Q5T4S7:
  • PCLVCNNPEV
  • FFCDCGA

Post-translational modifications for UBR4 Gene

  • Ubiquitination at posLast=11501150, posLast=17411741, posLast=34053405, isoforms=2, 3, 44035, posLast=41224122, posLast=42154215, and posLast=47124712

Domains & Families for UBR4 Gene

Gene Families for UBR4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

Q5T4S7

UniProtKB/Swiss-Prot:

UBR4_HUMAN :
  • Belongs to the UBR4 family.
Family:
  • Belongs to the UBR4 family.
genes like me logo Genes that share domains with UBR4: view

Function for UBR4 Gene

Molecular function for UBR4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.

Enzyme Numbers (IUBMB) for UBR4 Gene

Phenotypes From GWAS Catalog for UBR4 Gene

Gene Ontology (GO) - Molecular Function for UBR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 23932781
GO:0005515 protein binding IPI 16061792
GO:0005516 calmodulin binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UBR4: view
genes like me logo Genes that share phenotypes with UBR4: view

Animal Models for UBR4 Gene

MGI Knock Outs for UBR4:

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBR4 Gene

Localization for UBR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBR4 Gene

Membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBR4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Centrosome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with UBR4: view

Pathways & Interactions for UBR4 Gene

genes like me logo Genes that share pathways with UBR4: view

UniProtKB/Swiss-Prot Q5T4S7-UBR4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0016567 protein ubiquitination IEA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA 23932781
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with UBR4: view

No data available for SIGNOR curated interactions for UBR4 Gene

Drugs & Compounds for UBR4 Gene

(5) Drugs for UBR4 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
HspE7 Investigational Pharma Target 0
PCL-016 Investigational Pharma Target 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for UBR4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBR4: view

Transcripts for UBR4 Gene

Unigene Clusters for UBR4 Gene

Ubiquitin protein ligase E3 component n-recognin 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBR4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
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