UBR4 Gene
protein-coding GIFtS: 54
GCID: GC01M019401
|
|
ubiquitin protein ligase E3 component n-recognin 4(Previous names: zinc finger, UBR1 type 1 )
(Previous symbol: ZUBR1)
| |
Aliases
for UBR4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Protein Ligase E3 Component N-Recognin 41 2 | | P6001 | | RBAF6001 2 3 5 | | Zinc Finger, UBR1 Type 11 | | ZUBR11 2 3 5 | | E3 Ubiquitin-Protein Ligase UBR42 | | KIAA13071 3 5 | | Retinoblastoma-Associated Factor 600-Like Protein2 | | KIAA04621 3 | | 600 KDa Retinoblastoma Protein-Associated Factor3 | | Retinoblastoma-Associated Factor Of 600 KDa2 3 | | EC 6.3.2.-3 | | Zinc Finger UBR1-Type Protein 12 3 | | EC 6.3.28 | | N-Recognin-41 | | |
Export aliases for UBR4 gene to outside databasesPrevious GC identifers: GC01M019274 GC01M017647 |
Summaries
for UBR4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBR4:
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associatedprotein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be acytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this proteinis a target of the human papillomavirus type 16 E7 oncoprotein. (provided by RefSeq, Aug 2010)
UniProtKB/Swiss-Prot: UBR4_HUMAN, Q5T4S7Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteinsbearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to theirubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membranemorphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation ofFAK in response to cell-matrix interactions
Gene Wiki entry for UBR4
|
Genomic Views
for UBR4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBR4 gene promoter:
c-Fos STAT1 AML1a AP-1 STAT1beta STAT1alpha HEN1 POU2F1a SEF-1 (1) c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBR4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBR4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13UBR4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M019401: view genomic region
(about GC identifiers)
Start:
|
19,401,000 bp from pter |
End:
|
19,536,770 bp from pter |
Size:
|
135,771 bases |
Orientation:
|
minus strand |
|
Proteins
for UBR4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBR4_HUMAN, Q5T4S7 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase UBR4 Size: 5183 amino acids; 573841 Da
Subunit: Interacts with RB1 and calmodulin. Interacts with protein E7 from papilloma virus HPV-16, HPV-6B and HPV-11
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.Note=Concentrates at the leading edge of membrane structures involved in actin motility
Sequence caution: Sequence=CAD43719.1; Type=Erroneous initiation; Sequence=CAI19271.1; Type=Erroneous gene modelprediction;
Secondary accessions: A8MPT2 A8MQ33 A8MQB1 O60646 O75050 Q4QRK5 Q5T4S8 Q5T4S9 Q5TBN8 Q5TBP2 Q6DKH8Q6P4A4 Q7L8P7 Q8IXJ4 Q8TDN5 Q8WV67 Q9HA46 Q9P2N9 Q9UG82Alternative splicing: 6 isoforms: Q5T4S7-1 Q5T4S7-2 Q5T4S7-3 Q5T4S7-4 Q5T4S7-5 Q5T4S7-6 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UBR4: NX_Q5T4S7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T4S7
2 DME Specific Peptides for UBR4 (Q5T4S7)
UBR4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065816.2
ENSEMBL proteins: ENSP00000364403 ENSP00000364373 ENSP00000364372 ENSP00000364366 ENSP00000395313 ENSP00000404897 ENSP00000391875 ENSP00000364416 ENSP00000364365 ENSP00000364374 ENSP00000444070 ENSP00000394173 Reactome Protein details: Q5T4S7
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
UBR4 for ontologies About GeneDecksing
UBR4 Antibody Products:
Assay Products for UBR4: |
Protein
Domains /
Families
for UBR4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBR4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5T4S7ProtoNet protein and cluster: Q5T4S7 1 Blocks protein family: IPB003126 Zn-finger (putative)
UniProtKB/Swiss-Prot: UBR4_HUMAN, Q5T4S7Similarity: Belongs to the UBR4 familySimilarity: Contains 1 UBR-type zinc finger |
Function
for UBR4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBR4_HUMAN, Q5T4S7Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteinsbearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to theirubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membranemorphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation ofFAK in response to cell-matrix interactionsEnzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBR4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBR4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBR4 (NM_020765) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBR4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UBR4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBR4 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
UBR4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for UBR4:
|
Pathways & Interactions
for UBR4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for UBR4
UniProtKB/Swiss-Prot: UBR4_HUMAN, Q5T4S7Pathway: Protein modification; protein ubiquitination
UBR4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBR4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/28 Interacting proteins for UBR4 (Q5T4S71, 2, 3 ENSP000003644034) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019048 | virus-host interaction |
IEA | -- | | GO:0044419 | interspecies interaction between organisms |
-- | -- |
UBR4 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBR4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBR4
4 HMDB Compounds for UBR4 About this table
Search CenterWatch for drugs/clinical trials and news about UBR4
|
Transcripts
for UBR4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBR4 gene: NM_020765.2 Unigene Clusters for UBR4: Ubiquitin protein ligase E3 component n-recognin 4 Hs.148078 [show with all ESTs], Hs.649405 [show with all ESTs]Unigene Representative Sequences: NM_020765, AK02410518/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000375254(uc001bbi.3) ENST00000375225(uc001bbf.3) ENST00000375224(uc001bbg.3)
ENST00000459947 ENST00000486515 ENST00000492606 ENST00000467272 ENST00000483922
ENST00000494503 ENST00000466969 ENST00000375218(uc001bbj.1) ENST00000425413
ENST00000417040 ENST00000475973 ENST00000465036 ENST00000419533(uc001bbl.1 uc001bbm.1)
ENST00000497018 ENST00000375267(uc009vph.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBR4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBR4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBR4 (NM_020765) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBR4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UBR4 |
Additional cDNA sequence: AK024105.1 24/43 DOTS entries (see all 43): DT.423572 DT.97858115 DT.455169 DT.100826626 DT.91769709 DT.92418388 DT.100826630 DT.91769707 DT.101961269 DT.92353227 DT.95367094 DT.102835166 DT.121394597 DT.121394640 DT.121394680 DT.91812628 DT.121394550 DT.40204945 DT.91769704 DT.97833323 DT.100038666 DT.403256 DT.95163020 DT.97857452 24/582 AceView cDNA sequences (see all 582): AI139494 BF769655 BQ276386 BP359954 BU184016 BQ955434 BX460563 AL707233 AA374653 AA496940 AI018651 BP344471 BC073905 BQ574710 AI056779 BM454370 BU625663 AA442961 BQ943700 AI937477 CD366815 BF769993 AI904000 BU196698
GeneLoc Exon Structure
5/48 Alternative Splicing Database (ASD) splice patterns (SP) for UBR4 (see all 48) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37a | · | 37b | ^ | 38 | ^ | 39 | ^ | 40 | ^ | 41 | ^ | 42a | · | 42b | ^ | 43 | ^ | 44a | · | 44b | · | 44c | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 44d | ^ | 45a | · | 45b | ^ | 46a | · | 46b | ^ | 47a | · | 47b | ^ | 48a | · | 48b | ^ | 49 | ^ | 50a | · | 50b | ^ | 51a | · | 51b | ^ | 52 | ^ | 53a | · | 53b | ^ | 54 | ^ | 55 | ^ | 56a | · | 56b | ^ | 57 | ^ | 58 | ^ | 59a | · | 59b | · | 59c | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 59d | ^ | 60a | · | 60b | · | 60c | ^ | 61 | ^ | 62a | · | 62b | ^ | 63a | · | 63b | ^ | 64a | · | 64b | ^ | 65a | · | 65b | · | 65c | ^ | 66 | ^ | 67a | · | 67b | ^ | 68a | · | 68b | ^ | 69a | · | 69b | · | 69c | ^ | 70a | · | 70b | ^ | 71 | ^ | 72a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 72b | ^ | 73a | · | 73b | ^ | 74a | · | 74b | ^ | 75a | · | 75b | · | 75c | ^ | 76a | · | 76b | ^ | 77a | · | 77b | ^ | 78a | · | 78b | · | 78c | ^ | 79a | · | 79b | ^ | 80a | · | 80b | ^ | 81 | ^ | 82 | ^ | 83 | ^ | 84a | · | 84b | ^ | 85a | · | 85b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
| ExUns: | 86 | ^ | 87a | · | 87b | ^ | 88a | · | 88b | ^ | 89 | ^ | 90a | · | 90b | ^ | 91a | · | 91b | ^ | 92 | ^ | 93 | ^ | 94 | ^ | 95a | · | 95b | ^ | 96 | ^ | 97a | · | 97b | ^ | 98 | ^ | 99 | ^ | 100a | · | 100b | ^ | 101 | ^ | 102a | · | 102b | ^ | 103a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | |
| SP3: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 103b | · | 103c | ^ | 104a | · | 104b | ^ | 105 | ^ |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for UBR4
|
Expression
for UBR4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBR4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTTGTCCCG
About this image
See UBR4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBR4
SOURCE GeneReport for Unigene clusters: Hs.148078 Hs.649405
SABiosciences Expression via Pathway-Focused PCR Array including UBR4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBR4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat UBR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBR4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBR4 |
Orthologs
for UBR4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBR4 gene from 9/27 species (see all 27) About this table
ENSEMBL Gene Tree for UBR4 (if available)
TreeFam Gene Tree for UBR4 (if available) |
Paralogs
for UBR4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for UBR4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBR4 (19401000 - 19536770 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBR4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBR4 |
|
Disorders
/ Diseases
for UBR4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBR4 for disorders About GeneDecksing
OMIM gene information: 609890
OMIM disorders: --
3  diseases for UBR4: About MalaCardsretinoblastoma melanoma papilloma
Human Genome Epidemiology (HuGE) Navigator: UBR4 (1 document)
Export disorders for UBR4 gene to outside databases
|
Publications
for UBR4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBR4 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with UBR4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600. (PubMed id 16061792)1, 2, 9 Huh K.-W.... Muenger K. (2005)
- p600, a unique protein required for membrane morphogenesis and cell survival. (PubMed id 16214886)1, 2 Nakatani Y.... Herlitz A.M. (2005)
- The response of autologous T cells to a human melanoma is dominated by mutated neoantigens. (PubMed id 16247014)1, 2 Lennerz V.... Woelfel T. (2005)
- A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. (PubMed id 16055722)1, 3 Tasaki T....Kwon Y.T. (2005)
- Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (1997)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
|
External Searches for UBR4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBR4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBR4 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing UBR4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBR4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBR4 gene:
Search GeneIP for patents involving UBR4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBR4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UBR4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBR4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBR4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBR4 | | OriGene 3'-UTR Clone for UBR4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBR4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBR4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UBR4 | | OriGene Custom Protein Services for UBR4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBR4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBR4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBR4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBR4 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBR4 |
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| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UBR4 |
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