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Aliases for UBR4 Gene

Aliases for UBR4 Gene

  • Ubiquitin Protein Ligase E3 Component N-Recognin 4 2 3 5
  • Retinoblastoma-Associated Factor Of 600 KDa 3 4
  • Zinc Finger UBR1-Type Protein 1 3 4
  • N-Recognin-4 3 4
  • RBAF600 3 4
  • ZUBR1 3 4
  • P600 3 4
  • Retinoblastoma-Associated Factor 600-Like Protein 3
  • 600 KDa Retinoblastoma Protein-Associated Factor 4
  • Zinc Finger, UBR1 Type 1 2
  • EC 6.3.2.- 4
  • KIAA0462 4
  • KIAA1307 4
  • EC 6.3.2 63

External Ids for UBR4 Gene

Previous HGNC Symbols for UBR4 Gene

  • ZUBR1

Previous GeneCards Identifiers for UBR4 Gene

  • GC01M019274
  • GC01M019401
  • GC01M017647

Summaries for UBR4 Gene

Entrez Gene Summary for UBR4 Gene

  • The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

GeneCards Summary for UBR4 Gene

UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4) is a Protein Coding gene. Among its related pathways are Immune System and Viral carcinogenesis. GO annotations related to this gene include binding and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for UBR4 Gene

  • E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.

Gene Wiki entry for UBR4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBR4 Gene

Genomics for UBR4 Gene

Regulatory Elements for UBR4 Gene

Promoters for UBR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBR4 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBR4 Gene

Chromosome:
1
Start:
19,074,506 bp from pter
End:
19,210,319 bp from pter
Size:
135,814 bases
Orientation:
Minus strand

Genomic View for UBR4 Gene

Genes around UBR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBR4 Gene

Proteins for UBR4 Gene

  • Protein details for UBR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4S7-UBR4_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase UBR4
    Protein Accession:
    Q5T4S7
    Secondary Accessions:
    • A8MPT2
    • A8MQ33
    • A8MQB1
    • O60646
    • O75050
    • Q4QRK5
    • Q5T4S8
    • Q5T4S9
    • Q5TBN8
    • Q5TBP2
    • Q6DKH8
    • Q6P4A4
    • Q7L8P7
    • Q8IXJ4
    • Q8TDN5
    • Q8WV67
    • Q9HA46
    • Q9P2N9
    • Q9UG82

    Protein attributes for UBR4 Gene

    Size:
    5183 amino acids
    Molecular mass:
    573841 Da
    Quaternary structure:
    • Interacts with RB1 and calmodulin. Interacts with protein E7 from papilloma virus HPV-16, HPV-6B and HPV-11.
    SequenceCaution:
    • Sequence=CAD43719.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19271.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UBR4 Gene

neXtProt entry for UBR4 Gene

Proteomics data for UBR4 Gene at MOPED

Selected DME Specific Peptides for UBR4 Gene

Post-translational modifications for UBR4 Gene

  • Ubiquitination at Lys 1150, Lys 1741, Lys 3405, Lys 4035, Lys 4122, Lys 4215, and Lys 4712
  • Modification sites at PhosphoSitePlus

Other Protein References for UBR4 Gene

Domains & Families for UBR4 Gene

Protein Domains for UBR4 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T4S7

UniProtKB/Swiss-Prot:

UBR4_HUMAN :
  • Belongs to the UBR4 family.
  • Contains 1 UBR-type zinc finger.
Family:
  • Belongs to the UBR4 family.
Similarity:
  • Contains 1 UBR-type zinc finger.
genes like me logo Genes that share domains with UBR4: view

Function for UBR4 Gene

Molecular function for UBR4 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.

Enzyme Numbers (IUBMB) for UBR4 Gene

Gene Ontology (GO) - Molecular Function for UBR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 23932781
GO:0005488 binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with UBR4: view
genes like me logo Genes that share phenotypes with UBR4: view

Animal Models for UBR4 Gene

MGI Knock Outs for UBR4:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBR4 Gene

Localization for UBR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBR4 Gene

Membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBR4 Gene COMPARTMENTS Subcellular localization image for UBR4 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 3
cytosol 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UBR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UBR4: view

Pathways & Interactions for UBR4 Gene

genes like me logo Genes that share pathways with UBR4: view

UniProtKB/Swiss-Prot Q5T4S7-UBR4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBR4 Gene

None

No data available for SIGNOR curated interactions for UBR4 Gene

Drugs & Compounds for UBR4 Gene

(5) Drugs for UBR4 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
HspE7 Investigational Pharma Target 0
PCL-016 Investigational Pharma Target 0

(1) Additional Compounds for UBR4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBR4: view

Transcripts for UBR4 Gene

Unigene Clusters for UBR4 Gene

Ubiquitin protein ligase E3 component n-recognin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBR4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
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Relevant External Links for UBR4 Gene

GeneLoc Exon Structure for
UBR4
ECgene alternative splicing isoforms for
UBR4

Expression for UBR4 Gene

mRNA expression in normal human tissues for UBR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBR4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.1) and Bone marrow mesenchymal stem cell (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBR4 Gene



SOURCE GeneReport for Unigene cluster for UBR4 Gene Hs.148078

genes like me logo Genes that share expression patterns with UBR4: view

Protein tissue co-expression partners for UBR4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBR4 Gene

Orthologs for UBR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBR4 36
  • 100 (a)
OneToOne
UBR4 35
  • 99.49 (n)
  • 99.9 (a)
cow
(Bos Taurus)
Mammalia UBR4 35
  • 89.85 (n)
  • 96.87 (a)
UBR4 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBR4 36
  • 98 (a)
OneToOne
UBR4 35
  • 91.72 (n)
  • 98.12 (a)
mouse
(Mus musculus)
Mammalia Ubr4 16
Ubr4 36
  • 97 (a)
OneToOne
Ubr4 35
  • 89.2 (n)
  • 96.95 (a)
oppossum
(Monodelphis domestica)
Mammalia UBR4 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBR4 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubr4 35
  • 88.93 (n)
  • 96.81 (a)
chicken
(Gallus gallus)
Aves UBR4 35
  • 81.09 (n)
  • 93.03 (a)
UBR4 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBR4 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3376 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ubr4 35
  • 76.54 (n)
  • 88.06 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12567 35
zebrafish
(Danio rerio)
Actinopterygii ubr4 36
  • 87 (a)
OneToOne
nrp1 35
ubr4 35
  • 76.15 (n)
  • 87.08 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001157 35
  • 50.43 (n)
  • 44.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta poe 36
  • 37 (a)
OneToOne
poe 35
  • 50.15 (n)
  • 43.21 (a)
worm
(Caenorhabditis elegans)
Secernentea C44E4.1 35
  • 41.26 (n)
  • 29.42 (a)
C44E4.1 36
  • 23 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5607 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
CSA.4499 36
  • 58 (a)
OneToMany
Species with no ortholog for UBR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBR4 Gene

ENSEMBL:
Gene Tree for UBR4 (if available)
TreeFam:
Gene Tree for UBR4 (if available)

Paralogs for UBR4 Gene

No data available for Paralogs for UBR4 Gene

Variants for UBR4 Gene

Sequence variations from dbSNP and Humsavar for UBR4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs16862578 - 19,173,066(+) GGTGG(C/T)ACAGT nc-transcript-variant, reference, missense
rs12584 - 19,086,767(-) AGGAG(A/G/T)TGGAG reference, missense
VAR_032195 A melanoma patient
rs2274010 - 19,078,050(-) AGGCA(A/G)TGAAG reference, missense
VAR_035540 A breast cancer sample

Structural Variations from Database of Genomic Variants (DGV) for UBR4 Gene

Variant ID Type Subtype PubMed ID
nsv834347 CNV Gain 17160897
nsv5298 CNV Insertion 18451855
nsv508980 CNV Insertion 20534489

Variation tolerance for UBR4 Gene

Residual Variation Intolerance Score: 0.00602% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.19; 90.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBR4 Gene

HapMap Linkage Disequilibrium report
UBR4
Human Gene Mutation Database (HGMD)
UBR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBR4 Gene

Disorders for UBR4 Gene

Relevant External Links for UBR4

Genetic Association Database (GAD)
UBR4
Human Genome Epidemiology (HuGE) Navigator
UBR4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBR4

No disorders were found for UBR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBR4 Gene

Publications for UBR4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600. (PMID: 16061792) Huh K.-W. … Muenger K. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23 25
  3. A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. (PMID: 16055722) Tasaki T. … Kwon Y.T. (Mol. Cell. Biol. 2005) 2 3
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for UBR4 Gene

Sources for UBR4 Gene

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