Aliases for UBR3 Gene
External Ids for UBR3 Gene
Previous HGNC Symbols for UBR3 Gene
Previous GeneCards Identifiers for UBR3 Gene
GeneCards Summary for UBR3 Gene
UBR3 (Ubiquitin Protein Ligase E3 Component N-Recognin 3 (Putative)) is a Protein Coding gene. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is UBR1.
UniProtKB/Swiss-Prot for UBR3 Gene
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610).