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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBR3 Gene

protein-coding   GIFtS: 48
GCID: GC02P170683

Ubiquitin Protein Ligase E3 Component N-Recognin 3 (Putative)

(Previous name: zinc finger protein 650)
(Previous symbol: ZNF650)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Protein Ligase E3 Component N-Recognin 3 (Putative)1 2     N-recognin-32 3
Zinc Finger Protein 6501 2 3     E3 Ubiquitin-Protein Ligase UBR32
ZNF6501 2 3     EC 6.3.2.-3
Ubiquitin-Protein Ligase E3-Alpha-32 3     KIAA20243
Ubiquitin-Protein Ligase E3-Alpha-III2 3     

External Ids:    HGNC: 304671   Entrez Gene: 1305072   Ensembl: ENSG000001443577   OMIM: 6138315   UniProtKB: Q6ZT123   

Export aliases for UBR3 gene to outside databases

Previous GC identifers: GC02P170494 GC02P170392 GC02P162572


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UBR3 Gene: 
UBR3 (ubiquitin protein ligase E3 component n-recognin 3 (putative)) is a protein-coding gene. Diseases associated with UBR3 include sjogren's syndrome, and fanconi's anemia. GO annotations related to this gene include ubiquitin-protein ligase activity and zinc ion binding. An important paralog of this gene is UBR2.

UniProtKB/Swiss-Prot: UBR3_HUMAN, Q6ZT12
Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins
bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their
ubiquitination and subsequent degradation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBR3 gene promoter:
         Nkx3-1   Nkx3-1 v4   AML1a   NRSF form 1   MIF-1   Cdc5   NRSF form 2   c-Ets-1   GATA-2   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

UBR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBR3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P170683:  view genomic region     (about GC identifiers)

Start:
170,683,968 bp from pter      End:
170,940,641 bp from pter
Size:
256,674 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBR3_HUMAN, Q6ZT12 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase UBR3  
Size: 1888 amino acids; 212433 Da
Subunit: Interacts with UBE2A and UBE2B (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAC23120.1; Type=Erroneous initiation; Sequence=BAC86783.1; Type=Erroneous initiation;
Sequence=BAC87032.1; Type=Erroneous initiation; Sequence=BAG64179.1; Type=Erroneous initiation;
Sequence=CAD38857.1; Type=Erroneous termination; Positions=1525; Note=Translated as Gln;
Secondary accessions: B4DZR7 Q2KHN5 Q6ZR55 Q6ZSC2 Q8IVE7 Q8ND96
Alternative splicing: 4 isoforms:  Q6ZT12-1   Q6ZT12-2   Q6ZT12-3   Q6ZT12-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBR3: NX_Q6ZT12

Explore proteomics data for UBR3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZT12

  • UBR3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBR3 Protein Expression
    REFSEQ proteins: NP_742067.3  
    ENSEMBL proteins: 
     ENSP00000272793   ENSP00000415982   ENSP00000376409   ENSP00000389097   ENSP00000408436  
     ENSP00000396068   ENSP00000376408  

    Human Recombinant Protein Products for UBR3: 
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    Novus Biologicals UBR3 Proteins
    Novus Biologicals UBR3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBR3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    UBR3 for ontologies           About GeneDecksing



    UBR3 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for UBR3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBR: Ubiquitin protein ligase E3 component n-recognins

    1 InterPro protein domain:
     IPR003126 Znf_N-recognin

    Graphical View of Domain Structure for InterPro Entry Q6ZT12

    ProtoNet protein and cluster: Q6ZT12

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: UBR3_HUMAN, Q6ZT12
    Similarity: Belongs to the UBR1 family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 UBR-type zinc finger


    UBR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBR3_HUMAN, Q6ZT12
    Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins
    bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their
    ubiquitination and subsequent degradation (By similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    UBR3 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ubr3):
     behavior/neurological  growth/size  homeostasis/metabolism  mortality/aging  taste/olfaction 

    UBR3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ubr3tm1Ytkw for UBR3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBR3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBR3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBR3 

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    SwitchGear 3'UTR luciferase reporter plasmidUBR3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for UBR3
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    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBR3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: UBR3_HUMAN, Q6ZT12
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/79 Interacting proteins for UBR3 (Q6ZT123 ENSP000003960684) via UniProtKB, MINT, STRING, and/or I2D (see all 79)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2BP631463, ENSP000002653394I2D: score=2 STRING: ENSP00000265339
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    UBE2AP494593, ENSP000003606134I2D: score=7 STRING: ENSP00000360613
    UBE2ZQ9H8323, ENSP000003542014I2D: score=1 STRING: ENSP00000354201
    UBCP0CG483, ENSP000003448184I2D: score=2 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001967suckling behavior ISS--
    GO:0006511ubiquitin-dependent protein catabolic process ISS--
    GO:0007608sensory perception of smell ISS--
    GO:0009790embryo development ISS--

    UBR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBR3

    Search CenterWatch for drugs/clinical trials and news about UBR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBR3 gene: 
    NM_172070.3  

    Unigene Cluster for UBR3:

    Ubiquitin protein ligase E3 component n-recognin 3 (putative)
    Hs.379548  [show with all ESTs]
    Unigene Representative Sequence: NM_172070
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272793(uc010fqa.3 uc010zdj.2) ENST00000430321(uc002ufr.4)
    ENST00000392632(uc002uft.4) ENST00000477461 ENST00000487689 ENST00000439681
    ENST00000444475 ENST00000465630 ENST00000474426(uc002ufu.4) ENST00000484596
    ENST00000418381(uc010zdi.2) ENST00000392631
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBR3
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate UBR3 (see all 40):
    hsa-miR-15a hsa-miR-139-5p hsa-miR-485-3p hsa-miR-218 hsa-miR-424 hsa-miR-1183 hsa-miR-15b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidUBR3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBR3
    Clone
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    OriGene ORF clones in mouse, rat for UBR3
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    GenScript: all cDNA clones in your preferred vector: UBR3 (NM_172070)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for UBR3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBR3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBR3

    Additional mRNA sequence: 

    AB095944.1 AK094741.1 AK126998.1 AK127553.1 AK128490.1 AK303062.1 AL834144.1 BC044060.1 
    BC044594.1 BC113010.2 BX649036.1 CR749469.1 

    10 DOTS entries:

    DT.443713  DT.91660924  DT.95311912  DT.91659086  DT.100667876  DT.120942765  DT.40216002  DT.99936504 
    DT.91684797  DT.99945813 

    24/119 AceView cDNA sequences (see all 119):

    CD723264 AI868084 CA447822 AA569001 BX494687 AI708334 AW273490 AA702634 
    AA729970 AA346107 AI760142 AI095873 BX110968 BU686724 CD678661 AI760153 
    AI560652 BU158552 BC044060 BQ718579 BM069750 BF364364 AI690247 BM925331 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for UBR3 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^
    SP1:                                            -     -                                                                 -     -                                 
    SP2:                                                                                -                                   -     -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                -                                                                           

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for UBR3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTAAACT
    UBR3 Expression
    About this image


    See UBR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBR3

    SOURCE GeneReport for Unigene cluster: Hs.379548
        SABiosciences Expression via Pathway-Focused PCR Array including UBR3: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBR3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBR3 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubr31 , 5 ubiquitin protein ligase E3 component n-recognin 31, 5 89.73(n)1
    95.44(a)1
      2 (40.95 cM)5
    687951  NM_177783.51  NP_808451.21 
     698972465 
    chicken
    (Gallus gallus)
    Aves ZNF6501 zinc finger protein 650 82.17(n)
    88.72(a)
      424158  XM_422004.3  XP_422004.3 
    lizard
    (Anolis carolinensis)
    Reptilia UBR36
    --
    Uncharacterized protein
    83(a)
    81(a)
    1 ↔ many
    1 ↔ many
    GL343362.1(628535-686181)
    GL343362.1(586587-612184)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb72f062 wufb72f06 73.66(n)   322753  57042958 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG425931 CG42593 47.52(n)
    40.33(a)
      31713  NM_132200.3  NP_572428.3 
    worm
    (Caenorhabditis elegans)
    Secernentea F10G7.106
    Protein F10G7.10, isoform b
    13(a)
    1 ↔ 1
    II(4713673-4726262)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBR16
    UBR26
    E3 ubiquitin ligase (N-recognin), forms heterodime...
    Cytoplasmic ubiquitin-protein ligase (E3); require...
    13(a)
    13(a)
    many ↔ many
    many ↔ many
    VII(859901-865753)
    XII(187663-193281)


    ENSEMBL Gene Tree for UBR3 (if available)
    TreeFam Gene Tree for UBR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBR3 gene
    UBR22  UBR12  
    1 SIMAP similar gene for UBR3 using alignment to 5 protein entries:     UBR3_HUMAN (see all proteins):
    DKFZp686N10185

    UBR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5087 SNPs in UBR3 are shown (see all 5087)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113888651,2
    C--170159306(+) GGTCC-/T/TT  
            
    TTTTT
    1 -- int10--------
    rs102070221,2
    C,H--170683375(+) CCTCCC/GGAGTA 1 -- us2k15Minor allele frequency- G:0.11NA WA CSA 9
    rs1426299121,2
    C--170683444(+) CAGGGC/TTTCAC 1 -- us2k10--------
    rs569638991,2
    C--170683517(+) AAGTGC/TTGGGA 1 -- us2k10--------
    rs130081461,2
    C,F,H--170683607(+) GGGGTC/TTCATT 1 -- us2k124Minor allele frequency- T:0.25NS EA NA WA CSA 2354
    rs1900024571,2
    --170683733(+) AAATAA/GTTGCC 1 -- us2k10--------
    rs1399524531,2
    --170683989(+) TGGCCC/TTGGAC 1 -- us2k10--------
    rs23035551,2
    C,A--170684224(-) CCGCCA/GGCAGC 2 A syn12Minor allele frequency- G:0.00NA 4
    rs1141537341,2
    F--170684524(+) GGCGCC/TTGCGA 2 A syn11Minor allele frequency- T:0.12WA 118
    rs790363041,2
    C,F--170684548(+) AACGTG/AATGCG 2 /V syn12Minor allele frequency- A:0.10WA EA 238

    HapMap Linkage Disequilibrium report for UBR3 (170683968 - 170933968 bp, first 250kb of UBR3)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for UBR3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672983CNV Deletion23128226
    esv2457130CNV Deletion19546169
    esv2657393CNV Deletion23128226
    nsv875407CNV Loss21882294
    nsv10201CNV Loss18304495


    Human Gene Mutation Database (HGMD): UBR3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UBR3
    DNA2.0 Custom Variant and Variant Library Synthesis for UBR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613831    OMIM disorders: --

    3 diseases for UBR3:    About MalaCards
    sjogren's syndrome    fanconi's anemia    anemia


    UBR3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UBR3
    Human Genome Epidemiology (HuGE) Navigator: UBR3 (1 document)

    Export disorders for UBR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBR3 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with UBR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Confirmation of genomewide association signals in Chi nese Han population reveals risk loci for ischemic stroke. (PubMed id 19910543)1, 4 Ding H....Wang D.W. (2010)
    2. Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems. (PubMed id 17462990)1, 3 Tasaki T....Kwon Y.T. (2007)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    6. Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability. (PubMed id 21933813)1 Meisenberg C....Dianov G.L. (2012)
    7. Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS prote ins. (PubMed id 21816346)1 Lee P.C....Harper J.W. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 130507 HGNC: 30467 AceView: KIAA2024 Ensembl:ENSG00000144357 euGenes: HUgn130507
    ECgene: UBR3 H-InvDB: UBR3

    (According to HUGE)
    About This Section
    HUGE: KIAA2024

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBR3 gene:
    Search GeneIP for patents involving UBR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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