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Aliases for UBR3 Gene

Aliases for UBR3 Gene

  • Ubiquitin Protein Ligase E3 Component N-Recognin 3 (Putative) 2 3
  • Zinc Finger Protein 650 2 3 4
  • Ubiquitin-Protein Ligase E3-Alpha-III 3 4
  • Ubiquitin-Protein Ligase E3-Alpha-3 3 4
  • N-Recognin-3 3 4
  • ZNF650 3 4
  • E3 Ubiquitin-Protein Ligase UBR3 3
  • EC 6.3.2.- 4
  • KIAA2024 4

External Ids for UBR3 Gene

Previous Symbols for UBR3 Gene

  • ZNF650

Summaries for UBR3 Gene

GeneCards Summary for UBR3 Gene

UBR3 (Ubiquitin Protein Ligase E3 Component N-Recognin 3 (Putative)) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBR1.

UniProtKB/Swiss-Prot for UBR3 Gene

  • E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBR3 Gene

Genomics for UBR3 Gene

Genomic Location for UBR3 Gene

Start:
169,827,458 bp from pter
End:
170,084,131 bp from pter
Size:
256,674 bases
Orientation:
Plus strand

Genomic View for UBR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBR3 Gene

Regulatory Elements for UBR3 Gene

Proteins for UBR3 Gene

  • Protein details for UBR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZT12-UBR3_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase UBR3
    Protein Accession:
    Q6ZT12
    Secondary Accessions:
    • B4DZR7
    • Q2KHN5
    • Q6ZR55
    • Q6ZSC2
    • Q8IVE7
    • Q8ND96

    Protein attributes for UBR3 Gene

    Size:
    1888 amino acids
    Molecular mass:
    212433 Da
    Quaternary structure:
    • Interacts with UBE2A and UBE2B.
    SequenceCaution:
    • Sequence=BAC23120.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86783.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC87032.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG64179.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38857.1; Type=Erroneous termination; Positions=1525; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for UBR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBR3 Gene

Proteomics data for UBR3 Gene at MOPED

Post-translational modifications for UBR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBR3 Gene

No data available for DME Specific Peptides for UBR3 Gene

Domains for UBR3 Gene

Gene Families for UBR3 Gene

HGNC:
  • UBR :Ubiquitin protein ligase E3 component n-recognins

Protein Domains for UBR3 Gene

Blocks:
InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

UBR3_HUMAN
Family:
  • Belongs to the UBR1 family.:
    • Q6ZT12
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q6ZT12
  • Contains 1 UBR-type zinc finger.:
    • Q6ZT12
genes like me logo Genes that share domains with UBR3: view

Function for UBR3 Gene

Molecular function for UBR3 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).

Enzyme Numbers (IUBMB) for UBR3 Gene

Gene Ontology (GO) - Molecular Function for UBR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with UBR3: view
genes like me logo Genes that share phenotypes with UBR3: view

Animal Models for UBR3 Gene

MGI Knock Outs for UBR3:

miRNA for UBR3 Gene

miRTarBase miRNAs that target UBR3

No data available for Transcription Factor Targeting and HOMER Transcription for UBR3 Gene

Localization for UBR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBR3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBR3 Gene COMPARTMENTS Subcellular localization image for UBR3 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for UBR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UBR3: view

Pathways for UBR3 Gene

SuperPathways for UBR3 Gene

No Data Available

UniProtKB/Swiss-Prot Q6ZT12-UBR3_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for UBR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001967 suckling behavior ISS --
GO:0006511 ubiquitin-dependent protein catabolic process ISS --
GO:0007608 sensory perception of smell ISS --
GO:0009790 embryo development ISS --
genes like me logo Genes that share ontologies with UBR3: view

No data available for Pathways by source for UBR3 Gene

Transcripts for UBR3 Gene

Unigene Clusters for UBR3 Gene

Ubiquitin protein ligase E3 component n-recognin 3 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBR3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - -
SP2: - - -
SP3:
SP4:
SP5: -
SP6: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for UBR3 Gene

GeneLoc Exon Structure for
UBR3
ECgene alternative splicing isoforms for
UBR3

Expression for UBR3 Gene

mRNA expression in normal human tissues for UBR3 Gene

mRNA differential expression in normal tissues according to GTEx for UBR3 Gene

This gene is overexpressed in Muscle - Skeletal (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBR3 Gene

SOURCE GeneReport for Unigene cluster for UBR3 Gene Hs.379548

genes like me logo Genes that share expressions with UBR3: view

Orthologs for UBR3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBR3 36
  • 99.42 (n)
  • 99.5 (a)
cow
(Bos Taurus)
Mammalia UBR3 36
  • 94.1 (n)
  • 97.4 (a)
UBR3 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBR3 36
  • 94.82 (n)
  • 97.36 (a)
UBR3 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubr3 36
  • 89.55 (n)
  • 95.16 (a)
Ubr3 16
Ubr3 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 95 (a)
OneToMany
-- 37
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 90 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ubr3 36
  • 89.23 (n)
  • 95.12 (a)
chicken
(Gallus gallus)
Aves UBR3 37
  • 87 (a)
OneToOne
ZNF650 36
  • 82.22 (n)
  • 88.62 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 81 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ubr3 36
  • 76.16 (n)
  • 82.08 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01051288.2 37
  • 74 (a)
OneToMany
ubr3 36
  • 69.4 (n)
  • 75.08 (a)
ubr3 37
  • 68 (a)
OneToMany
wufb72f06 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000384 36
  • 44.28 (n)
  • 38.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42593 36
  • 48.24 (n)
  • 41.07 (a)
CG42593 37
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F10G7.10 37
  • 18 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBR1 37
  • 14 (a)
ManyToMany
UBR2 37
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3643 37
  • 34 (a)
OneToOne
Species with no ortholog for UBR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBR3 Gene

ENSEMBL:
Gene Tree for UBR3 (if available)
TreeFam:
Gene Tree for UBR3 (if available)

Paralogs for UBR3 Gene

Paralogs for UBR3 Gene

Selected SIMAP similar genes for UBR3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with UBR3: view

Variants for UBR3 Gene

Sequence variations from dbSNP and Humsavar for UBR3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1343 -- 170,082,149(-) TGATA(C/T)GCATT utr-variant-3-prime
rs2631 -- 170,038,300(+) TGAGA(A/C)TCTTT intron-variant
rs9631 -- 170,083,169(+) ACAAA(C/T)CTAAT utr-variant-3-prime
rs13781 -- 170,082,858(+) AAGGC(A/G)CAGTG utr-variant-3-prime
rs766524 -- 169,868,204(-) CTGAA(C/T)TGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBR3 Gene

Variant ID Type Subtype PubMed ID
nsv10201 CNV Loss 18304495
esv2657393 CNV Deletion 23128226
esv2672983 CNV Deletion 23128226
esv2457130 CNV Deletion 19546169
nsv875407 CNV Loss 21882294

Relevant External Links for UBR3 Gene

HapMap Linkage Disequilibrium report
UBR3
Human Gene Mutation Database (HGMD)
UBR3

Disorders for UBR3 Gene

Relevant External Links for UBR3

Genetic Association Database (GAD)
UBR3
Human Genome Epidemiology (HuGE) Navigator
UBR3
genes like me logo Genes that share disorders with UBR3: view

No data available for UniProtKB/Swiss-Prot for UBR3 Gene

Publications for UBR3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems. (PMID: 17462990) Tasaki T. … Kwon Y.T. (J. Biol. Chem. 2007) 2 3
  3. Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke. (PMID: 19910543) Ding H. … Wang D.W. (Stroke 2010) 3 49
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for UBR3 Gene

Sources for UBR3 Gene

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