UBR1 Gene
protein-coding GIFtS: 56
GCID: GC15M043235
|
|
ubiquitin protein ligase E3 component n-recognin 1
| |
Aliases
for UBR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin Protein Ligase E3 Component N-Recognin 11 2 | | E3 Ubiquitin-Protein Ligase UBR12 | | Ubiquitin-Protein Ligase E3-Alpha-12 3 | | E3a Ligase2 | | Ubiquitin-Protein Ligase E3-Alpha-I2 3 | | Ubiquitin Ligase E3 Alpha-I2 | | N-Recognin-11 | | Ubiquitin-Protein Ligase E3-Alpha2 | | JBS2 5 | | EC 6.3.2.-3 |
Export aliases for UBR1 gene to outside databasesPrevious GC identifers: GC15M038676 GC15M036130 GC15M040814 GC15M040953 GC15M041024 GC15M020083 |
Summaries
for UBR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBR1:
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway,encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in theformation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein.The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this genehave been associated with Johanson-Blizzard syndrome. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: UBR1_HUMAN, Q8IWV7Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteinsbearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to theirubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negativeregulator of the leucine-mTOR signaling pathway, thereby controlling cell growth
Gene Wiki entry for UBR1
|
Genomic Views
for UBR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBR1 gene promoter:
Pbx1a AP-1 ATF-2 NF-kappaB YY1 POU2F1 POU2F1a STAT3 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBR1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBR1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q13 Ensembl cytogenetic band: 15q15.2 HGNC cytogenetic band: 15q13UBR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M043235: view genomic region
(about GC identifiers)
Start:
|
43,235,095 bp from pter |
End:
|
43,398,311 bp from pter |
Size:
|
163,217 bases |
Orientation:
|
minus strand |
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Proteins
for UBR1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBR1_HUMAN, Q8IWV7 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase UBR1 Size: 1749 amino acids; 200211 Da
Subunit: Interacts with RECQL4
Subcellular location: Cytoplasm, cytosol
Developmental stage: Expressed in fetal pancreas
Sequence caution: Sequence=BAB55380.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for UBR1:3NY1 (3D)
Secondary accessions: O60708 O75492 Q14D45 Q68DN9 Q8IWY6 Q96JY4Alternative splicing: 2 isoforms: Q8IWV7-1 Q8IWV7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UBR1: NX_Q8IWV7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IWV7
UBR1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_777576.1
ENSEMBL proteins: ENSP00000290650 ENSP00000457573 ENSP00000457879 ENSP00000456327 ENSP00000455759 ENSP00000456502 ENSP00000454962 ENSP00000371612 Reactome Protein details: Q8IWV7
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
UBR1 for ontologies About GeneDecksing
UBR1 Antibody Products:
Assay Products for UBR1: |
Protein
Domains /
Families
for UBR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBR1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IWV7ProtoNet protein and cluster: Q8IWV7 3 Blocks protein families: IPB000307 Ribosomal protein S16 IPB003126 Zn-finger (putative) IPB003769 Protein of unknown function DUF174
UniProtKB/Swiss-Prot: UBR1_HUMAN, Q8IWV7Domain: The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of theclassical motifSimilarity: Belongs to the UBR1 familySimilarity: Contains 1 RING-type zinc fingerSimilarity: Contains 1 UBR-type zinc finger |
Function
for UBR1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBR1_HUMAN, Q8IWV7Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteinsbearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to theirubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negativeregulator of the leucine-mTOR signaling pathway, thereby controlling cell growthEnzyme Number (IUBMB): EC 6.3.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBR1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBR1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBR1 (NM_174916) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBR1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBR1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBR1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
UBR1 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for UBR1:
Animal Models:
Mouse knock-out Ubr1tm1Avar for UBR1
12 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ubr1):
UBR1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for UBR1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | | | 3 | Ubiquitin-Proteasome Dependent Proteolysis | | | 4 | SMAD Signaling Network | | | 5 | PEDF Induced Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBR1
5 
Reactome Pathways for UBR1
UniProtKB/Swiss-Prot: UBR1_HUMAN, Q8IWV7Pathway: Protein modification; protein ubiquitination
UBR1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBR1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/123 Interacting proteins for UBR1 (Q8IWV72, 3 ENSP000002906504) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- | | GO:0016567 | protein ubiquitination |
-- | -- | | GO:0032007 | negative regulation of TOR signaling cascade |
IMP | -- | | GO:0071233 | cellular response to leucine |
IDA | -- |
UBR1 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBR1
4 HMDB Compounds for UBR1 About this table
Search CenterWatch for drugs/clinical trials and news about UBR1
|
Transcripts
for UBR1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBR1 gene: NM_174916.2 Unigene Cluster for UBR1: Ubiquitin protein ligase E3 component n-recognin 1 Hs.591121 [show with all ESTs]Unigene Representative Sequence: NM_17491612 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000290650(uc001zqq.3) ENST00000562173 ENST00000566493 ENST00000568782
ENST00000546274(uc010udk.1) ENST00000569243 ENST00000564540 ENST00000569066
ENST00000569971 ENST00000563239 ENST00000569337 ENST00000382177
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBR1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBR1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBR1 (NM_174916) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBR1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBR1 |
Additional cDNA sequence: AF061556.1 AF525401.1 AK027803.1 AK054969.1 AK056441.1 AK127478.1 AK292516.1 AK302489.1 AY061886.1 BC113505.1 BC113507.1 BX648400.1 11 DOTS entries: DT.110605 DT.95265244 DT.100015554 DT.121051298 DT.100783497 DT.75171179 DT.91746805 DT.95132882 DT.121051497 DT.40295353 DT.91938887 24/221 AceView cDNA sequences (see all 221): BM718298 BQ002107 BU618516 CA417209 AK054969 AI051367 AL597596 AA300527 BX103491 BU741892 AA946678 CA440743 CR607973 C01573 AI928868 BX119443 BX281065 BM508126 AI582335 CA313244 BU623096 AI399787 AI694170 CB159971
GeneLoc Exon Structure
|
Expression
for UBR1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGAAGTTAT
About this image
See UBR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBR1
SOURCE GeneReport for Unigene cluster: Hs.591121
UniProtKB/Swiss-Prot: UBR1_HUMAN, Q8IWV7Tissue specificity: Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinarcells of the pancreas (at protein level)
SABiosciences Expression via Pathway-Focused PCR Arrays including UBR1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBR1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBR1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBR1 |
Orthologs
for UBR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBR1 gene from 9/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ubr11 , 5 |
ubiquitin protein ligase E3 component n-recognin 11, 5 |
88.05(n)1
92.57(a)1 |
|
2 (60.37 cM)5
222221 NM_009461.21 NP_033487.21
1208602695 |
chicken
(Gallus gallus) |
Aves |
UBR11 |
ubiquitin protein ligase E3 component n-recognin 1 |
75.89(n)
78.15(a) |
|
423242 XM_421165.3 XP_421165.2 |
lizard
(Anolis carolinensis) |
Reptilia |
---- |
-- |
77(a)72(a) |
many → 1many → 1 |
1(39461276-39486919) 1(39489008-39522232) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.75162 |
Xenopus laevis transcribed sequence with moderate similarity more |
75.84(n) |
|
BG364916.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ubr11 |
ubiquitin protein ligase E3 component n-recognin 1 |
60.66(n)
56.92(a) |
|
568531 XM_002665218.2 XP_002665264.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG90866 |
-- |
29(a) |
1 → many |
X(16850978-16862682) |
worm
(Caenorhabditis elegans) |
Secernentea |
ubr-16 |
E3 ubiquitin-protein ligase ubr-1 |
21(a) |
1 → many |
I(3807460-3816799) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PRT66 |
proteolysis 6 |
15(a) |
1 → many |
5(474279-482783) |
rice
(Oryza sativa) |
Liliopsida |
-- |
zinc finger protein, putative, expressed |
16(a) |
1 → many |
1(2598850-2611865) |
ENSEMBL Gene Tree for UBR1 (if available)
TreeFam Gene Tree for UBR1 (if available) |
Paralogs
for UBR1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBR1 gene
- UBR22 UBR32
1 SIMAP similar gene for UBR1 using alignment to 7 protein entries: UBR1_HUMAN (see all proteins):UBR2
UBR1 for paralogs About GeneDecksing
|
Genomic Variants
for UBR1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBR1 (43235095 - 43398311 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UBR1
1 CNV: 49556
Human Gene Mutation Database (HGMD): UBR1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBR1 |
|
Disorders
/ Diseases
for UBR1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBR1 for disorders About GeneDecksing
OMIM gene information: 605981
OMIM disorders: 243800
UniProtKB/Swiss-Prot: UBR1_HUMAN, Q8IWV7
Defects in UBR1 are a cause of Johanson-Blizzard syndrome (JBS) [MIM:243800]. This disorder includescongenital exocrine pancreatic insufficiency, multiple malformations such as nasal wing aplasia, and frequent mentalretardation. Pancreas of individuals with JBS do not express UBR1 and show intrauterine-onset destructive pancreatitis
15  diseases for UBR1: About MalaCardsjohanson-blizzard syndrome limb-girdle muscular dystrophy congenital dyserythropoietic anemia type i congenital dyserythropoietic anemia
dyserythropoietic anemia imperforate anus vitelliform macular dystrophy exocrine pancreatic insufficiency
rapadilino syndrome macular dystrophy muscular dystrophy intellectual disability
anemia cardiomyopathy pancreatitis
5 diseases from the University of Copenhagen DISEASES database for UBR1:Johanson-Blizzard syndrome Exocrine pancreatic insufficiency Intellectual disability Rapadilino syndrome
Imperforate anus Human Genome Epidemiology (HuGE) Navigator: UBR1 (2 documents)
Export disorders for UBR1 gene to outside databases
|
Publications
for UBR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBR1 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with UBR1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The mouse and human genes encoding the recognition component of the N-end rule pathway. (PubMed id 9653112)1, 2, 3 Kwon Y.T.... Varshavsky A. (1998)
- Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). (PubMed id 16311597)1, 2 Zenker M.... Reis A. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Regulation of protein catabolism by muscle-specific and cytokine- inducible ubiquitin ligase E3alpha-II during cancer cachexia. (PubMed id 15548684)1, 2 Kwak K.S.... Han H.Q. (2004)
- RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. (PubMed id 15317757)1, 2 Yin J.... Wang W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. (PubMed id 12434312)1, 2 Dgany O.... Tamary H. (2002)
- Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. (PubMed id 20298436)2, 9 Kume K....Handa H. (2010)
- Johanson-Blizzard syndrome caused by identical UBR1 mutations in two unrelated girls, one with a cardiomyopathy. (PubMed id 19006206)1, 9 Elting M....Cobben J.M. (2008)
- Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing. (PubMed id 19058315)1, 9 Alkhouri N....Zenker M. (2008)
|
External Searches for UBR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBR1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBR1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBR1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBR1 gene:
Search GeneIP for patents involving UBR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBR1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UBR1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBR1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBR1 | | | OriGene Protein Over-expression Lysate for UBR1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBR1 | | OriGene 3'-UTR Clone for UBR1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBR1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBR1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UBR1 | | OriGene Custom Protein Services for UBR1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBR1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBR1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBR1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBR1 |
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| | | | Search Tocris compounds for UBR1 |
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 | | | UBR1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBR1 |
|  |  |  | | | | Search ThermoFisher Antibodies for UBR1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBR1 |
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