Aliases for UBQLNL Gene
External Ids for UBQLNL Gene
- HGNC: 28294
- Entrez Gene: 143630
- Ensembl: ENSG00000175518
- UniProtKB: Q8IYU4
Previous GeneCards Identifiers for UBQLNL Gene
- GC11M005511
- GC11M005514
- GC11M005517
- GC11M005520
- GC11M005527
- GC11M005535
- GC11M005193
Summaries for UBQLNL Gene
GeneCards Summary for UBQLNL Gene
UBQLNL (Ubiquilin Like) is a Protein Coding gene. An important paralog of this gene is UBQLN1.
Additional gene information for UBQLNL Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBQLNL Gene
Genomics for UBQLNL Gene
GeneHancer (GH) Regulatory Elements for UBQLNL Gene
Promoters and enhancers for UBQLNL Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11I005516 | Promoter | 0.5 | EPDnew | 550.8 | +0.0 | 7 | 0.1 | UBQLNL OLFM5P UBQLN3 HBG2 | ||
GH11I005518 | Enhancer | 0.4 | FANTOM5 | 611.8 | -1.8 | -1814 | 0.1 | ATF2 | UBQLNL UBQLN3 OLFM5P HBG2 | |
GH11I005618 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE dbSUPER | 14.8 | -103.6 | -103623 | 3.8 | TFAP4 FOXA2 TEAD4 TAL1 SIN3A RARA ZNF7 TCF12 CTBP1 FOXK2 | TRIM34 TRIM5 UBQLNL ENSG00000239920 HBG2 TRIM6 TRIM22 TRIM6-TRIM34 GC11P005579 | |
GH11I005504 | Enhancer | 0.9 | ENCODE | 6 | +11.6 | 11572 | 2.2 | HDGF PKNOX1 SMAD1 ATF1 ARNT TCF12 POLR2B ZNF766 GATA2 ATF7 | ENSG00000167355 OR51B5 HBE1 FAM160A2 DNHD1 TRIM34 UBQLNL OR52D1 HBG2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around UBQLNL on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for UBQLNL Gene
Genomic Locations for UBQLNL Gene
- chr11:5,514,393-5,516,726
- (GRCh38/hg38)
- Size:
- 2,334 bases
- Orientation:
- Minus strand
- chr11:5,535,623-5,537,956
- (GRCh37/hg19)
Genomic View for UBQLNL Gene
Genes around UBQLNL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.4 by Ensembl
- 11p15.4 by Entrez Gene
- 11p15.4 by HGNC
UBQLNL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)


RefSeq DNA sequence for UBQLNL Gene
Proteins for UBQLNL Gene
-
Protein details for UBQLNL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IYU4-UBQLN_HUMAN
- Recommended name:
- Ubiquilin-like protein
- Protein Accession:
- Q8IYU4
- Q6ZRU1
- Q96EK3
- Q96MB0
Protein attributes for UBQLNL Gene
- Size:
- 475 amino acids
- Molecular mass:
- 52897 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAC87218.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};
Post-translational modifications for UBQLNL Gene
No Post-translational modifications
Other Protein References for UBQLNL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for UBQLNL
- Novus Biologicals Antibodies for UBQLNL
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Protein Products
-
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-
Abcam proteins for UBQLNL
Assay Products
No data available for DME Specific Peptides for UBQLNL Gene
Domains & Families for UBQLNL Gene
Gene Families for UBQLNL Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for UBQLNL Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for UBQLNL Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for UBQLNL Gene
Function for UBQLNL Gene
Phenotypes for UBQLNL Gene
- MGI mutant phenotypes for UBQLNL:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for UBQLNL:
Animal Models for UBQLNL Gene
- MGI Knock Outs for UBQLNL:
-
- Ubqlnl tm1(KOMP)Vlcg
Animal Model Products
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-
-
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-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBQLNL
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miRNA for UBQLNL Gene
- miRTarBase miRNAs that target UBQLNL
miRNA Products
- Search ViGene Biosciences for UBQLNL
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for UBQLNL gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for UBQLNL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for UBQLNL
-
ViGene Biosciences adenoviral particle packaged cDNA for UBQLNL gene
-
ViGene Biosciences lentiviral particle packaged cDNA for UBQLNL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for UBQLNL gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBQLNL Gene
Localization for UBQLNL Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for UBQLNL Gene
Pathways & Interactions for UBQLNL Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for UBQLNL Gene
Transcripts for UBQLNL Gene
mRNA/cDNA for UBQLNL Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for UBQLNL
- genomics-online: gRNA clones - Search results for 86 available UBQLNL gene related products
- Overview of 86 available UBQLNL gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBQLNL
- GenScript: Design CRISPR guide RNA sequences for UBQLNL
miRNA Products
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Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for UBQLNL
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- genomics-online: shRNA clones - Search results for 86 available UBQLNL gene related products
- Overview of 86 available UBQLNL gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for UBQLNL gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for UBQLNL
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for UBQLNL
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for UBQLNL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for UBQLNL Gene
mRNA differential expression in normal tissues according to GTEx for UBQLNL Gene
This gene is overexpressed in Testis (x26.0).
NURSA nuclear receptor signaling pathways regulating expression of UBQLNL Gene:
UBQLNLSOURCE GeneReport for Unigene cluster for UBQLNL Gene:
Hs.10688Primer Products
-
OriGene qPCR primer pairs for UBQLNL
-
OriGene qPCR primer pairs and template standards for UBQLNL
- genomics-online: primer clones - Search results for 86 available UBQLNL gene related products
- Overview of 86 available UBQLNL gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBQLNL Gene
Orthologs for UBQLNL Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | UBQLNL 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | UBQLNL 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | UBQLNL 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Ubqlnl 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ubqlnl 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | UBQLNL 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
fruit fly (Drosophila melanogaster) |
Insecta | Ubqn 34 |
|
ManyToMany | |
CG31528 34 |
|
ManyToMany | |||
worm (Caenorhabditis elegans) |
Secernentea | ubql-1 34 |
|
OneToMany | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DSK2 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10824 34 |
|
OneToMany |
- Species where no ortholog for UBQLNL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for UBQLNL Gene
Variants for UBQLNL Gene
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1001052588 | -- | 5,516,961(-) | G/A | upstream_transcript_variant | |
rs1001086988 | -- | 5,516,746(-) | C/G | upstream_transcript_variant | |
rs1001569880 | -- | 5,516,289(-) | C/T | coding_sequence_variant, synonymous_variant | |
rs1001691107 | -- | 5,517,272(-) | TTTTTT/TTTTTTT | upstream_transcript_variant | |
rs1001995049 | -- | 5,517,640(-) | C/G | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3625230 | CNV | loss | 21293372 |
nsv1046068 | CNV | gain | 25217958 |
nsv1048608 | CNV | gain | 25217958 |
nsv510997 | OTHER | complex | 20534489 |
nsv553240 | CNV | loss | 21841781 |
nsv553241 | CNV | gain | 21841781 |
nsv832057 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.73;
73.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for UBQLNL Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBQLNL Gene
Disorders for UBQLNL Gene
Additional Disease Information for UBQLNL
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for UBQLNL Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBQLNL Gene
Publications for UBQLNL Gene
- The ubiquilin gene family: evolutionary patterns and functional insights. (PMID: 24674348) Marín I (BMC evolutionary biology 2014) 2 3 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
Products for UBQLNL Gene
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- Invitrogen Antibodies for UBQLNL
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for UBQLNL
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available UBQLNL related products ranked by validation data
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Sources for UBQLNL Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew