UBQLNL Gene
protein-coding GIFtS: 45
GCID: GC11M005547
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ubiquilin-like
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Aliases
for UBQLNL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquilin-Like1 | | MGC204701 | | MGC269581 | | Ubiquilin-Like Protein2 |
Export aliases for UBQLNL gene to outside databasesPrevious GC identifers: GC11M005511 GC11M005514 GC11M005517 GC11M005520 GC11M005527 GC11M005535 GC11M005193 |
Summaries
for UBQLNL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for UBQLNL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBQLNL gene promoter:
E2F-3a E2F-4 E2F-5 p300 E2F-2 GATA-1 E2F-1 E2F POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBQLNL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBQLNL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4UBQLNL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M005547: view genomic region
(about GC identifiers)
Start:
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5,535,623 bp from pter |
End:
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5,537,956 bp from pter |
Size:
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2,334 bases |
Orientation:
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minus strand |
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Proteins
for UBQLNL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBQLN_HUMAN, Q8IYU4 (See
protein sequence)Recommended Name: Ubiquilin-like protein Size: 475 amino acids; 52897 Da
Sequence caution: Sequence=BAC87218.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;
Secondary accessions: Q6ZRU1 Q96EK3 Q96MB0Alternative splicing: 2 isoforms: Q8IYU4-1 Q8IYU4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UBQLNL: NX_Q8IYU4
UBQLNL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_659490.4
ENSEMBL proteins: ENSP00000369531
Human Recombinant Protein Products:
UBQLNL Antibody Products:
Assay Products for UBQLNL: |
Protein
Domains /
Families
for UBQLNL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBQLNL for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IYU4ProtoNet protein and cluster: Q8IYU4 1 Blocks protein family: IPB000626 Ubiquitin domain
UniProtKB/Swiss-Prot: UBQLN_HUMAN, Q8IYU4Similarity: Contains 1 ubiquitin-like domain |
Function
for UBQLNL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBQLNL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBQLNL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBQLNL (NM_145053) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBQLNL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBQLNL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBQLNL |
|
Pathways & Interactions
for UBQLNL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein processing in endoplasmic reticulum | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for UBQLNL):
UBQLNL for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBQLNL
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for UBQLNL (Q8IYU43 ENSP000003695314) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for UBQLNL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBQLNL
Search CenterWatch for drugs/clinical trials and news about UBQLNL / UBQLN
|
Transcripts
for UBQLNL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBQLNL gene: NM_145053.4 Unigene Cluster for UBQLNL: Ubiquilin-like Hs.10688 [show with all ESTs]Unigene Representative Sequence: NM_1450531 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000380184(uc001maz.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBQLNL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBQLNL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBQLNL (NM_145053) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBQLNL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBQLNL |
Additional cDNA sequence: AK057255.1 BC012183.1 BC034977.2 4 DOTS entries: DT.100015415 DT.95155461 DT.208296 DT.101962175 17 AceView cDNA sequences: NM_145053 BC034977 BG336938 AI028325 BC012183 AK057255 BP371259 BI825528 AI377594 BG719342 BI462302 AA972837 T60072 AI023222 AI014955 AI910861 AK127987
GeneLoc Exon Structure
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Expression
for UBQLNL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBQLNL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAATCTACA
About this image
See UBQLNL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBQLNL
SOURCE GeneReport for Unigene cluster: Hs.10688
SABiosciences Custom PCR Arrays for UBQLNL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBQLNL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBQLNL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBQLNL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBQLNL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBQLNL |
Orthologs
for UBQLNL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBQLNL gene from 5/23 species (see all 23) About this table
ENSEMBL Gene Tree for UBQLNL (if available)
TreeFam Gene Tree for UBQLNL (if available) |
Paralogs
for UBQLNL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBQLNL gene
- UBQLN32 UBQLN22 UBQLN42 UBQLN12
UBQLNL for paralogs About GeneDecksing
|
Genomic Variants
for UBQLNL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBQLNL (5535623 - 5537956 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UBQLNL
1 CNV: 34458 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBQLNL |
|
Disorders
/ Diseases
for UBQLNL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBQLNL for disorders About GeneDecksing
1  disease for UBQLNL: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: UBQLNL (2 documents)
Export disorders for UBQLNL gene to outside databases
|
Publications
for UBQLNL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBQLNL gene integrated from 9 sources:
(articles sorted by number of sources associating them with UBQLNL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for UBQLNL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing UBQLNL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBQLNL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBQLNL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBQLNL | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for UBQLNL gene:
Search GeneIP for patents involving UBQLNL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBQLNL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UBQLNL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBQLNL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBQLNL | | | OriGene Protein Over-expression Lysate for UBQLNL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBQLNL | | OriGene 3'-UTR Clone for UBQLNL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBQLNL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBQLNL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for UBQLNL | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UBQLNL | | OriGene Custom Protein Services for UBQLNL | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBQLNL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBQLNL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBQLNL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBQLNL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBQLNL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBQLNL |
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 |  |  |  | |
| | | | Search Tocris compounds for UBQLNL |
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 | | | UBQLNL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBQLNL |
|  |  |  | | | | Search ThermoFisher Antibodies for UBQLNL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBQLNL |
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