UBQLNL Gene
protein-coding GIFtS: 46
GCID: GC11M005547
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Ubiquilin-Like
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Aliases
for UBQLNL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| ubiquilin-like1 2 | | Ubiquilin-Like Protein2 |
Export aliases for UBQLNL gene to outside databasesPrevious GC identifers: GC11M005511 GC11M005514 GC11M005517 GC11M005520 GC11M005527 GC11M005535 GC11M005193 |
Summaries
for UBQLNL gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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GeneCards Summary for UBQLNL Gene:
UBQLNL (ubiquilin-like) is a protein-coding gene. An important paralog of this gene is UBQLN3.
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Genomic Views
for UBQLNL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000011.10 NC_018922.2 NT_009237.19
Regulatory elements:
 Regulatory transcription factor binding sites in the UBQLNL gene promoter:
E2F-3a E2F-4 E2F-5 p300 E2F-2 GATA-1 E2F-1 E2F POU2F1 POU2F1a
Other transcription factors
Search Chromatin IP Primers for UBQLNL
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBQLNL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4UBQLNL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M005547: view genomic region
(about GC identifiers)
Start:
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5,535,623 bp from pter |
End:
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5,537,956 bp from pter |
Size:
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2,334 bases |
Orientation:
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minus strand |
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Proteins
for UBQLNL gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UBQLN_HUMAN, Q8IYU4 (See
protein sequence)Recommended Name: Ubiquilin-like protein Size: 475 amino acids; 52897 Da
Sequence caution: Sequence=BAC87218.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;
Secondary accessions: Q6ZRU1 Q96EK3 Q96MB0Alternative splicing: 2 isoforms: Q8IYU4-1 Q8IYU4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UBQLNL: NX_Q8IYU4
Explore proteomics data for UBQLNL at MOPED
See UBQLNL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins: NP_659490.4
ENSEMBL proteins: ENSP00000369531
UBQLNL Human Recombinant
Protein Products:UBQLNL Antibody
Products:UBQLNL Assay Products: |
Domains /
Families
for UBQLNL gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | HGNC Gene Families:
UBQLN: Ubiquilin family
2 InterPro protein domains:Graphical View of Domain Structure for InterPro Entry Q8IYU4ProtoNet protein and cluster: Q8IYU4 1 Blocks protein domain: IPB000626 Ubiquitin domain
UniProtKB/Swiss-Prot: UBQLN_HUMAN, Q8IYU4Similarity: Contains 1 ubiquitin-like domain
UBQLNL for domains About GeneDecksing
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Function
for UBQLNL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Gene Ontology (GO): 1 molecular function term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005515 | protein binding |
-- | -- |
UBQLNL for ontologies About GeneDecksing
Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for UBQLNL
| | | Predesigned siRNA for gene silencing in human, mouse, rat UBQLNL |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for UBQLNL | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for UBQLNL  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBQLNL |
Localization
for UBQLNL gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from COMPARTMENTS:
| Compartment | Confidence |
|---|
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| cytosol | 2 | | mitochondrion | 2 | | nucleus | 1 | | peroxisome | 1 |
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Pathways & Interactions
for UBQLNL gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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SuperPaths for UBQLNL About  See pathways by source
Pathways by source See SuperPaths
Show all pathways
1  Kegg Pathway (Kegg details for UBQLNL):
UBQLNL for pathways About GeneDecksing
Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBQLNL
Interactions:
Search GeneGlobe Interaction Network for UBQLNL
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins for UBQLNL (Q8IYU43 ENSP000003695314) via UniProtKB, MINT, STRING, and/or I2D (see all 27)About this table
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Drugs & Compounds
for UBQLNL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
TryGeneCards Plus |  Browse compounds at ApexBio
 Browse Tocris compounds for UBQLNL (UBQLN)
|
Transcripts
for UBQLNL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for UBQLNL gene: NM_145053.4 Unigene Cluster for UBQLNL: Ubiquilin-like Hs.10688 [show with all ESTs]Unigene Representative Sequence: NM_1450531 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000380184(uc001maz.4)
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for UBQLNL
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat UBQLNL |
Primer
Products: | | OriGene qPCR primer pairs and template standards for UBQLNL
OriGene qSTAR qPCR primer pairs in human, mouse for UBQLNL
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBQLNL | | | QuantiTect SYBR Green Assays in human, mouse, rat UBQLNL | | | QuantiFast Probe-based Assays in human, mouse, rat UBQLNL |
Additional mRNA sequence: AK057255.1 BC012183.1 BC034977.2 4 DOTS entries: DT.100015415 DT.95155461 DT.208296 DT.101962175 17 AceView cDNA sequences: NM_145053 AK057255 BI825528 BC034977 AI028325 BP371259 AI377594 BG336938 BG719342 AA972837 BC012183 BI462302 T60072 AI014955 AI023222 AI910861 AK127987
GeneLoc Exon Structure
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Expression
for UBQLNL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
TryGeneCards Plus | UBQLNL expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCAATCTACA
About this image UBQLNL Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
SOURCE GeneReport for Unigene cluster: Hs.10688
Custom PCR Arrays for UBQLNL
Primer
Products: | | OriGene qPCR primer pairs and template standards for UBQLNL
OriGene qSTAR qPCR primer pairs in human, mouse for UBQLNL
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBQLNL | | | QuantiTect SYBR Green Assays in human, mouse, rat UBQLNL | | | QuantiFast Probe-based Assays in human, mouse, rat UBQLNL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBQLNL |
Orthologs
for UBQLNL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of animals and fungi.
Orthologs for UBQLNL gene from Selected species (see all 12) About this table
ENSEMBL Gene Tree for UBQLNL (if available)
TreeFam Gene Tree for UBQLNL (if available) |
Paralogs
for UBQLNL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for UBQLNL gene
- UBQLN32 UBQLN22 UBQLN42 UBQLN12
UBQLNL for paralogs About GeneDecksing
|
Genomic Variants
for UBQLNL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBQLNL (5535623 - 5537956 bp)
Structural Variations
Database of Genomic Variants (DGV) 4 variations for UBQLNL: About this table
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing UBQLNL |
|
Disorders
/ Diseases
for UBQLNL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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UBQLNL for disorders About GeneDecksing
Genetic Association Database (GAD): UBQLNL
Human Genome Epidemiology (HuGE) Navigator: UBQLNL (2 documents)
Export disorders for UBQLNL gene to outside databases
|
Publications
for UBQLNL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for UBQLNL gene integrated from 10 sources:
(articles sorted by number of sources associating them with UBQLNL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
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External Searches for UBQLNL gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing UBQLNL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
Other Databases showing UBQLNL gene
(According to HUGE)
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Specialized Databases showing UBQLNL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for UBQLNL | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
TryGeneCards Plus | Patent Information for UBQLNL gene:
Search GeneIP for patents involving UBQLNL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBQLNL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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|  | Block miRNA regulation of human, mouse, rat UBQLNL using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing UBQLNL | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBQLNL | | Predesigned siRNA for gene silencing in human, mouse, rat UBQLNL | | | QuantiFast Probe-based Assays in human, mouse, rat UBQLNL | | QuantiTect SYBR Green Assays in human, mouse, rat UBQLNL | | | Custom PCR Arrays for UBQLNL | | Search Chromatin IP Primers for UBQLNL | | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBQLNL | | Search GeneGlobe Interaction Network for UBQLNL | | | Regulatory tfbs in UBQLNL promoter |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBQLNL |
| |  |  |  |  | | | Search ThermoFisher Antibodies for UBQLNL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBQLNL |
| | | | LSBio Antibodies in human, mouse, rat for UBQLNL |
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