UBQLNL Gene

Aliases
for UBQLNL gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC11M005511 GC11M005514 GC11M005517 GC11M005520 GC11M005527 GC11M005535 GC11M005193

Summaries
for UBQLNL gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for UBQLNL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000011.9  NC_018922.2  NT_009237.19  

SwitchGear Promoter luciferase reporter plasmid: UBQLNL promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBQLNL

UBQLNL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M005547:  view genomic region     (about GC identifiers)

Proteins
for UBQLNL gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for UBQLNL: NX_Q8IYU4

Explore proteomics data for UBQLNL at MOPED


See UBQLNL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

UBQLNL Human Recombinant Protein Products:

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	antibodies-online peptides for UBQLNL

UBQLNL Antibody Products:

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UBQLNL Assay Products:

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	antibodies-online kits for UBQLNL (6 products)

Domains /
Families
for UBQLNL gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8IYU4

Find genes that share domains with UBQLNL           About GenesLikeMe

Function
for UBQLNL gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for UBQLNL

miRNA Products:		Block miRNA regulation of human, mouse, rat UBQLNL using miScript Target Protectors
		8 qRT-PCR Assays for microRNAs that regulate UBQLNL:
		hsa-miR-15a hsa-miR-497 hsa-miR-424 hsa-miR-1909* hsa-miR-296-3p hsa-miR-195 hsa-miR-16 hsa-miR-15b
		SwitchGear 3'UTR luciferase reporter plasmid: UBQLNL 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat UBQLNL

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for UBQLNL

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		GenScript: all cDNA clones in your preferred vector: UBQLNL (NM_145053)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBQLNL

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBQLNL

Localization
for UBQLNL gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Pathways & Interactions
for UBQLNL gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Drugs & Compounds
for UBQLNL gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Transcripts
for UBQLNL gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for UBQLNL gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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UBQLNL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCAATCTACA

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for UBQLNL OriGene qSTAR qPCR primer pairs in human, mouse for UBQLNL
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBQLNL
		QuantiTect SYBR Green Assays in human, mouse, rat UBQLNL
		QuantiFast Probe-based Assays in human, mouse, rat UBQLNL

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBQLNL

Orthologs
for UBQLNL gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for UBQLNL gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for UBQLNL gene

UBQLN3²  UBQLN2²  UBQLN4²  UBQLN1²  

Find genes that share paralogs with UBQLNL           About GenesLikeMe

Genomic Variants
for UBQLNL gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for UBQLNL (see all 184)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs9344601,2	C,F,O,A,H	--	5535182(-)	AAGACG/TGCCTG	1	--	ds5001		21		MN NA NS EA WA CSA	1212
rs1432562681,2		--	5535203(+)	TATCTA/GGGCCT	1	--	ds5001		0	--	--	--	--
rs169321931,2	C,F,H	--	5535354(+)	GTATAT/CGTGAA	1	--	ds5001		9		NA NS EA CSA	566
rs3963281,2	C,F,A,H	--	5535375(-)	ACAAGG/CTCACA	1	--	ds5001		26		NS EA NA WA CSA	2566
rs1399842331,2	C	--	5535424(+)	TAATC-/AGTTTC	1	--	ds5001		0	--	--	--	--
rs1862045471,2		--	5535458(+)	TACCAA/TGCTCA	1	--	ds5001		0	--	--	--	--
rs1915483121,2		--	5535459(+)	ACCATA/GCTCAA	1	--	ds5001		0	--	--	--	--
rs1157220601,2	F	--	5535502(+)	TTTATC/TTCTAT	1	--	ds5001		1		WA	118
rs1483959941,2		--	5535518(+)	TATATG/TCATGT	1	--	ds5001		0	--	--	--	--
rs108382451,2	C,F,A,H	--	5535529(+)	GGTTTG/TTGTGT	1	--	ds5001		27		NS EA NA WA CSA	2772

HapMap Linkage Disequilibrium report for UBQLNL (5535623 - 5537956 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for UBQLNL:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv896939	CNV	Loss	21882294
nsv896940	CNV	Loss	21882294
nsv832057	CNV	Loss	17160897
nsv510997	CNV	Complex	20534489

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing UBQLNL

DNA2.0 Custom Variant and Variant Library Synthesis for UBQLNL

Disorders / Diseases
for UBQLNL gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Publications
for UBQLNL gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for UBQLNL gene integrated from 10 sources: (articles sorted by number of sources associating them with UBQLNL)

Utopia: connect your pdf to the dynamic world of online information

1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (Nature 2006)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

External Searches for UBQLNL gene

Genome Databases showing UBQLNL gene

Other Databases showing UBQLNL gene

Specialized Databases showing UBQLNL gene

Products
for UBQLNL gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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