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Aliases for UBQLNL Gene

Aliases for UBQLNL Gene

  • Ubiquilin Like 2 3 5

External Ids for UBQLNL Gene

Previous GeneCards Identifiers for UBQLNL Gene

  • GC11M005511
  • GC11M005514
  • GC11M005517
  • GC11M005520
  • GC11M005527
  • GC11M005535
  • GC11M005193

Summaries for UBQLNL Gene

GeneCards Summary for UBQLNL Gene

UBQLNL (Ubiquilin Like) is a Protein Coding gene. An important paralog of this gene is UBQLN1.

Additional gene information for UBQLNL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBQLNL Gene

Genomics for UBQLNL Gene

GeneHancer (GH) Regulatory Elements for UBQLNL Gene

Promoters and enhancers for UBQLNL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I005516 Promoter 0.5 EPDnew 550.8 +0.0 7 0.1 UBQLNL OLFM5P UBQLN3 HBG2
GH11I005518 Enhancer 0.4 FANTOM5 611.8 -1.8 -1814 0.1 ATF2 UBQLNL UBQLN3 OLFM5P HBG2
GH11I005618 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 14.8 -103.6 -103623 3.8 TFAP4 FOXA2 TEAD4 TAL1 SIN3A RARA ZNF7 TCF12 CTBP1 FOXK2 TRIM34 TRIM5 UBQLNL ENSG00000239920 HBG2 TRIM6 TRIM22 TRIM6-TRIM34 GC11P005579
GH11I005504 Enhancer 0.9 ENCODE 6 +11.6 11572 2.2 HDGF PKNOX1 SMAD1 ATF1 ARNT TCF12 POLR2B ZNF766 GATA2 ATF7 ENSG00000167355 OR51B5 HBE1 FAM160A2 DNHD1 TRIM34 UBQLNL OR52D1 HBG2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBQLNL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBQLNL gene promoter:

Genomic Locations for UBQLNL Gene

Genomic Locations for UBQLNL Gene
chr11:5,514,393-5,516,726
(GRCh38/hg38)
Size:
2,334 bases
Orientation:
Minus strand
chr11:5,535,623-5,537,956
(GRCh37/hg19)

Genomic View for UBQLNL Gene

Genes around UBQLNL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBQLNL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBQLNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBQLNL Gene

Proteins for UBQLNL Gene

  • Protein details for UBQLNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYU4-UBQLN_HUMAN
    Recommended name:
    Ubiquilin-like protein
    Protein Accession:
    Q8IYU4
    Secondary Accessions:
    • Q6ZRU1
    • Q96EK3
    • Q96MB0

    Protein attributes for UBQLNL Gene

    Size:
    475 amino acids
    Molecular mass:
    52897 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC87218.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

    Alternative splice isoforms for UBQLNL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBQLNL Gene

Post-translational modifications for UBQLNL Gene

No Post-translational modifications

Other Protein References for UBQLNL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBQLNL Gene

Domains & Families for UBQLNL Gene

Gene Families for UBQLNL Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBQLNL Gene

Suggested Antigen Peptide Sequences for UBQLNL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBQLNL: view

No data available for UniProtKB/Swiss-Prot for UBQLNL Gene

Function for UBQLNL Gene

genes like me logo Genes that share phenotypes with UBQLNL: view

Animal Models for UBQLNL Gene

MGI Knock Outs for UBQLNL:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBQLNL Gene

Localization for UBQLNL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBQLNL gene
Compartment Confidence
mitochondrion 2
cytosol 2
peroxisome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for UBQLNL Gene

Pathways & Interactions for UBQLNL Gene

SuperPathways for UBQLNL Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBQLNL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBQLNL Gene

Drugs & Compounds for UBQLNL Gene

No Compound Related Data Available

Transcripts for UBQLNL Gene

mRNA/cDNA for UBQLNL Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UBQLNL Gene

Ubiquilin-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBQLNL Gene

No ASD Table

Relevant External Links for UBQLNL Gene

GeneLoc Exon Structure for
UBQLNL
ECgene alternative splicing isoforms for
UBQLNL

Expression for UBQLNL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBQLNL Gene

mRNA differential expression in normal tissues according to GTEx for UBQLNL Gene

This gene is overexpressed in Testis (x26.0).

NURSA nuclear receptor signaling pathways regulating expression of UBQLNL Gene:

UBQLNL

SOURCE GeneReport for Unigene cluster for UBQLNL Gene:

Hs.10688
genes like me logo Genes that share expression patterns with UBQLNL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBQLNL Gene

Orthologs for UBQLNL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBQLNL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBQLNL 33 34
  • 98.95 (n)
dog
(Canis familiaris)
Mammalia UBQLNL 33 34
  • 81.29 (n)
cow
(Bos Taurus)
Mammalia UBQLNL 33 34
  • 79.68 (n)
mouse
(Mus musculus)
Mammalia Ubqlnl 33 16 34
  • 73.62 (n)
rat
(Rattus norvegicus)
Mammalia Ubqlnl 33
  • 72.85 (n)
oppossum
(Monodelphis domestica)
Mammalia UBQLNL 34
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 19 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ubqn 34
  • 20 (a)
ManyToMany
CG31528 34
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ubql-1 34
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DSK2 34
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10824 34
  • 20 (a)
OneToMany
Species where no ortholog for UBQLNL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UBQLNL Gene

ENSEMBL:
Gene Tree for UBQLNL (if available)
TreeFam:
Gene Tree for UBQLNL (if available)

Paralogs for UBQLNL Gene

Paralogs for UBQLNL Gene

genes like me logo Genes that share paralogs with UBQLNL: view

Variants for UBQLNL Gene

Sequence variations from dbSNP and Humsavar for UBQLNL Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001052588 -- 5,516,961(-) G/A upstream_transcript_variant
rs1001086988 -- 5,516,746(-) C/G upstream_transcript_variant
rs1001569880 -- 5,516,289(-) C/T coding_sequence_variant, synonymous_variant
rs1001691107 -- 5,517,272(-) TTTTTT/TTTTTTT upstream_transcript_variant
rs1001995049 -- 5,517,640(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for UBQLNL Gene

Variant ID Type Subtype PubMed ID
esv3625230 CNV loss 21293372
nsv1046068 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv510997 OTHER complex 20534489
nsv553240 CNV loss 21841781
nsv553241 CNV gain 21841781
nsv832057 CNV loss 17160897

Variation tolerance for UBQLNL Gene

Residual Variation Intolerance Score: 94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.73; 73.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBQLNL Gene

Human Gene Mutation Database (HGMD)
UBQLNL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBQLNL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBQLNL Gene

Disorders for UBQLNL Gene

Additional Disease Information for UBQLNL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UBQLNL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBQLNL Gene

Publications for UBQLNL Gene

  1. The ubiquilin gene family: evolutionary patterns and functional insights. (PMID: 24674348) Marín I (BMC evolutionary biology 2014) 2 3 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for UBQLNL Gene

Sources for UBQLNL Gene

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