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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBQLN4 Gene

protein-coding   GIFtS: 56
GCID: GC01M156005

Ubiquilin 4

(Previous name: chromosome 1 open reading frame 6)
(Previous symbol: C1orf6)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquilin 41 2     A1Up2 3
C1orf61 2 3 5     CIP752 3
Ataxin-1 Ubiquitin-Like Interacting Protein1 2     UBIN2 3
Ataxin-1 Interacting Ubiquitin-Like Protein2 3     A1U2 5
Ataxin-1 Ubiquitin-Like-Interacting Protein A1U2 3     Chromosome 1 Open Reading Frame 61
Connexin43-Interacting Protein Of 75 KDa2 3     ubiquilin-42

External Ids:    HGNC: 12371   Entrez Gene: 568932   Ensembl: ENSG000001608037   OMIM: 6054405   UniProtKB: Q9NRR53   

Export aliases for UBQLN4 gene to outside databases

Previous GC identifers: GC00U920633 GC01M152819 GC01M154271 GC01M127367


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UBQLN4 Gene: 
UBQLN4 (ubiquilin 4) is a protein-coding gene. Diseases associated with UBQLN4 include mumps. GO annotations related to this gene include protein binding and polyubiquitin binding. An important paralog of this gene is UBQLN3.

UniProtKB/Swiss-Prot: UBQL4_HUMAN, Q9NRR5
Function: Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or
inhibit proteasomal protein degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBQLN4 gene promoter:
         Pax-5   MIF-1   Nkx2-5   AP-2gamma   Tal-1beta   GATA-1   HEN1   Pax-3   Sox9   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBQLN4 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBQLN4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBQLN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21

UBQLN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBQLN4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156005:  view genomic region     (about GC identifiers)

Start:
156,005,092 bp from pter      End:
156,023,585 bp from pter
Size:
18,494 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBQL4_HUMAN, Q9NRR5 (See protein sequence)
Recommended Name: Ubiquilin-4  
Size: 601 amino acids; 63853 Da
Subunit: Binds signal sequences of proteins that are targeted to the endoplasmic reticulum. Interacts (via UBA
domain) with GJA1 (not ubiquitinated) and with ubiquitin; both compete for the same binding site (By similarity).
Homodimer. Interacts (via UBA domain) with ubiquitin and with polyubiquitin chains. Interacts (via ubiquitin-like
domain) with PSMD4, a regulatory subunit of the 26S proteasome. Interacts with ATXN1/SCA1. Interaction with ATXN1
inhibits polyubiquitination of UBQLN4 and interferes with PSMD4 binding
Subcellular location: Nucleus. Cytoplasm. Endoplasmic reticulum (Probable). Cytoplasm, perinuclear region (By
similarity). Note=Colocalizes with the proteasome, both in nucleus and cytoplasm. May associate with the
endoplasmic reticulum
Sequence caution: Sequence=AAF19084.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH06410.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6ND44 B2RAY7 Q5VYA0 Q5VYA1 Q9BR98 Q9UHX4
Alternative splicing: 2 isoforms:  Q9NRR5-1   Q9NRR5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBQLN4: NX_Q9NRR5

Explore proteomics data for UBQLN4 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated; this does not lead to proteasomal degradation. May undergo both 'Lys-48'- and 'Lys-63'-linked
    polyubiquitination
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRR5

  • UBQLN4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBQLN4 Protein Expression
    REFSEQ proteins: NP_064516.2  
    ENSEMBL proteins: 
     ENSP00000357292   ENSP00000357290  

    Human Recombinant Protein Products for UBQLN4: 
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    Cloud-Clone Corp. Proteins for UBQLN4 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11001934
    GO:0005737cytoplasm IDA11001934
    GO:0005789endoplasmic reticulum membrane ISS--
    GO:0005829cytosol ISS--
    GO:0031595colocalizes with nuclear proteasome complex IDA15280365

    UBQLN4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBQLN: Ubiquilin family

    5/7 InterPro protein domains (see all 7):
     IPR006636 STI1_HS-bd
     IPR000449 UBA/transl_elong_EF1B_N
     IPR015940 UBA/transl_elong_EF1B_N_euk
     IPR015496 Ubiquilin
     IPR000626 Ubiquitin

    Graphical View of Domain Structure for InterPro Entry Q9NRR5

    ProtoNet protein and cluster: Q9NRR5

    2 Blocks protein domains:
    IPB000449 Ubiquitin-associated domain
    IPB000626 Ubiquitin domain


    UniProtKB/Swiss-Prot: UBQL4_HUMAN, Q9NRR5
    Similarity: Contains 1 UBA domain
    Similarity: Contains 1 ubiquitin-like domain


    UBQLN4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBQL4_HUMAN, Q9NRR5
    Function: Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or
    inhibit proteasomal protein degradation

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684damaged DNA binding ----
    GO:0005488binding ----
    GO:0005515protein binding IPI11001934
    GO:0031593polyubiquitin binding IDA15280365
    GO:0042802identical protein binding IPI11001934
         
    UBQLN4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBQLN4:
     Decreased Tat-dependent transc  Decreased circadian period len  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBQLN4 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBQLN4 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidUBQLN4 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBQLN4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for UBQLN4):
        Protein processing in endoplasmic reticulum


    UBQLN4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBQLN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/242 Interacting proteins for UBQLN4 (Q9NRR51, 2, 3 ENSP000003572924) via UniProtKB, MINT, STRING, and/or I2D (see all 242)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3, ENSP000003651314MINT-2864537 MINT-2864556 I2D: score=3 STRING: ENSP00000365131
    PDLIM7Q9NR121, 2, 3, ENSP000003480994EBI-711226,EBI-350517 MINT-2866276 I2D: score=3 STRING: ENSP00000348099
    TRIM32Q130491, 2, 3, ENSP000003630954EBI-711226,EBI-742790 MINT-2870049 I2D: score=3 STRING: ENSP00000363095
    ZNF205O952011, 2, 3, ENSP000002190914EBI-711226,EBI-747343 MINT-2864265 I2D: score=3 STRING: ENSP00000219091
    ENSG00000096155P463792, 3MINT-2864537 MINT-2864556 I2D: score=3 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006289nucleotide-excision repair ----
    GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process IMP15280365
    GO:0043161proteasomal ubiquitin-dependent protein catabolic process ----

    UBQLN4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBQLN4 (UBQL4)

    Search CenterWatch for drugs/clinical trials and news about UBQLN4 / UBQL4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBQLN4 gene: 
    NM_020131.3  

    Unigene Cluster for UBQLN4:

    Ubiquilin 4
    Hs.283739  [show with all ESTs]
    Unigene Representative Sequence: BC063841
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368309(uc001fna.3 uc010pgx.2) ENST00000368307 ENST00000459954
    ENST00000472638
    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate UBQLN4 (see all 24):
    hsa-miR-122* hsa-miR-520d-5p hsa-miR-106a hsa-miR-650 hsa-miR-3122 hsa-miR-93 hsa-miR-199b-5p hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidUBQLN4 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209566.1 AF113544.1 AK098368.1 AK302895.1 AK314413.1 BC006410.1 BC018403.2 BC063841.1 

    13 DOTS entries:

    DT.214071  DT.101981956  DT.120849768  DT.97859907  DT.95153030  DT.120871086  DT.100794412  DT.95173913 
    DT.100794408  DT.121330596  DT.95173914  DT.95173916  DT.100031376 

    24/247 AceView cDNA sequences (see all 247):

    BM762843 BU177287 NM_020131 F29863 BM783703 AL537660 BI094116 BM783229 
    BX367321 AI393494 CR617278 CR625574 BQ954658 BE297586 BM783581 BM760774 
    BU186471 AA878060 AI656602 BC063841 BQ650391 BM773525 BQ068720 AI002534 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for UBQLN4 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15
    SP1:                                                                                                  -                                 
    SP2:                                                                                                                                    
    SP3:                                                  -     -                                                                           
    SP4:        -     -     -                                                                                                               
    SP5:              -     -                                                                                                               


    ECgene alternative splicing isoforms for UBQLN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBQLN4 expression in normal human tissues (normalized intensities)      UBQLN4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGAGAATA
    UBQLN4 Expression
    About this image


    UBQLN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus

    See UBQLN4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBQLN4

    SOURCE GeneReport for Unigene cluster: Hs.283739

    UniProtKB/Swiss-Prot: UBQL4_HUMAN, Q9NRR5
    Tissue specificity: Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at
    lower levels in placenta, lung and liver

        SABiosciences Custom PCR Arrays for UBQLN4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBQLN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBQLN4 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubqln41 , 5 ubiquilin 41, 5 90.81(n)1
    93.11(a)1
      3 (38.87 cM)5
    942321  NM_033526.21  NP_277068.11 
     885537165 
    chicken
    (Gallus gallus)
    Aves UBQLN41 ubiquilin 4 78.92(n)
    85.33(a)
      426353  NM_001031373.1  NP_001026544.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia ubin-pending-prov2 chromosome 1 open reading frame 6 80.08(n)    BC047982.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb48e112 Danio rerio cDNA clone MGC66188 IMAGE5605506, complete more 79.3(n)    BC055536.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubqn6
    CG315286
    --
    47(a)
    26(a)
    many ↔ many
    many ↔ many
    X(19577781-19581273)
    3R(242160-243387)
    worm
    (Caenorhabditis elegans)
    Secernentea ubql-16
    Protein UBQL-1, isoform a
    36(a)
    1 → many
    I(7021982-7029076)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DSK26
    Nuclear-enriched ubiquitin-like polyubiquitin-bind...
    29(a)
    1 → many
    XIII(818827-819948)


    ENSEMBL Gene Tree for UBQLN4 (if available)
    TreeFam Gene Tree for UBQLN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBQLN4 gene
    UBQLN32  UBQLN22  UBQLN12  UBQLNL2  
    2 SIMAP similar genes for UBQLN4 using alignment to 2 protein entries:     UBQL4_HUMAN (see all proteins):
    UBQLN1    UBQLN2

    UBQLN4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UBQLN4
    PGOHUM00000240987


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/309 SNPs in UBQLN4 are shown (see all 309)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118096901,2
    C,F,H--162505478(+) TATCCC/TTTAAC 1 -- int17Minor allele frequency- T:0.01EA NS NA 908
    rs602158581,2
    C--162505533(+) ATATA-/TA/T  
      ATATAT
    ATTTT
    1 -- int11NA 2
    rs75172021,2
    C,F,A--162505543(+) TTTTTT/CCTTTT 1 -- int14Minor allele frequency- C:0.37NA WA 242
    rs1456184751,2
    --162505589(+) GCAGCA/GGCGCA 1 -- int10--------
    rs1382308831,2
    --162505965(+) CTCTCA/TCAACA 1 -- ut310--------
    rs560618541,2
    C--162506302(+) AGGGGC/GTCTGG 1 -- ut310--------
    rs557571851,2
    C--162506428(+) AGAGCC/TCCAAG 1 -- ut310--------
    rs360853451,2
    --162506646(+) TCAAAC/TTACTG 1 -- ut310--------
    rs348559981,2
    --162506717(+) CACATA/GTGCTT 1 -- ut310--------
    rs1874854341,2
    --162506727(+) TGAGGA/TACTAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for UBQLN4 (156005092 - 156023585 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UBQLN4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509513CNV Insertion20534489

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605440    OMIM disorders: --

    2 diseases for UBQLN4:    About MalaCards
    mumps    


    UBQLN4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UBQLN4
    Human Genome Epidemiology (HuGE) Navigator: UBQLN4 (1 document)

    Export disorders for UBQLN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBQLN4 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with UBQLN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein. (PubMed id 11001934)1, 2, 3, 9 Davidson J.D....Orr H.T. (2000)
    2. Identification of two paralogous regions mapping to the short and long arms of human chromosome 2 comprising LIS1 pseudogenes. (PubMed id 10575211)1, 2, 3 Fogli A.... Carrozzo R. (1999)
    3. The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up. (PubMed id 15280365)1, 2, 9 Riley B.E....Orr H.T. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Ubiquilin4 is an adaptor protein that recruits Ubiquil in1 to the autophagy machinery. (PubMed id 23459205)1 Yun Lee D....Brown E.J. (2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56893 HGNC: 1237 AceView: C1orf6 Ensembl:ENSG00000160803 euGenes: HUgn56893
    ECgene: UBQLN4 Kegg: 56893 H-InvDB: UBQLN4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBQLN4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBQLN4 gene:
    Search GeneIP for patents involving UBQLN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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