Aliases for UBQLN4 Gene
External Ids for UBQLN4 Gene
Previous HGNC Symbols for UBQLN4 Gene
Previous GeneCards Identifiers for UBQLN4 Gene
GeneCards Summary for UBQLN4 Gene
UBQLN4 (Ubiquilin 4) is a Protein Coding gene. Diseases associated with UBQLN4 include Spinocerebellar Ataxia 1. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include identical protein binding and damaged DNA binding. An important paralog of this gene is UBQLN1.
UniProtKB/Swiss-Prot for UBQLN4 Gene
Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (Ref. 6). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205).