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UBQLN3 Gene

protein-coding   GIFtS: 52
GCID: GC11M005485

Ubiquilin 3

  Search for UBQLN3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquilin 31 2
TUP-12
ubiquilin-32

External Ids:    HGNC: 125101   Entrez Gene: 506132   Ensembl: ENSG000001755207   OMIM: 6054735   UniProtKB: Q9H3473   

Export aliases for UBQLN3 gene to outside databases

Previous GC identifers: GC11M006276 GC11M005830 GC11M005487 GC11M005492 GC11M005188


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBQLN3 Gene:
Summary: This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with
related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal
ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus
thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein
degradation. This gene is specifically expressed in the testis, and proposed to regulate cell-cycle progression
during spermatogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBQLN3 Gene:
UBQLN3 (ubiquilin 3) is a protein-coding gene. An important paralog of this gene is UBQLN2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBQLN3 gene promoter:
         E2F-3a   E2F-4   E2F-5   p300   MyoD   E2F-2   E2F-1   E2F   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBQLN3 promoter sequence
   Search Chromatin IP Primers for UBQLN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBQLN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15

UBQLN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBQLN3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M005485:  view genomic region     (about GC identifiers)

Start:
5,528,530 bp from pter      End:
5,531,215 bp from pter
Size:
2,686 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBQL3_HUMAN, Q9H347 (See protein sequence)
Recommended Name: Ubiquilin-3  
Size: 655 amino acids; 70841 Da
Sequence caution: Sequence=AAG41675.1; Type=Erroneous gene model prediction;
3 PDB 3D structures from and Proteopedia for UBQLN3:
1WX7 (3D)        1YQB (3D)        2DAH (3D)    
Secondary accessions: Q9NRE0

Explore the universe of human proteins at neXtProt for UBQLN3: NX_Q9H347

Explore proteomics data for UBQLN3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UBQLN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_059509.1  
    ENSEMBL proteins: 
     ENSP00000347997   ENSP00000412561  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBQLN: Ubiquilin family

    Selected InterPro protein domains (see all 6):
     IPR015496 Ubiquilin
     IPR000626 Ubiquitin_dom
     IPR009060 UBA-like
     IPR006636 STI1_HS-bd
     IPR000449 UBA/Ts_N

    Graphical View of Domain Structure for InterPro Entry Q9H347

    ProtoNet protein and cluster: Q9H347

    2 Blocks protein domains:
    IPB000449 Ubiquitin-associated domain
    IPB000626 Ubiquitin domain


    UniProtKB/Swiss-Prot: UBQL3_HUMAN, Q9H347
    Similarity: Contains 1 UBA domain
    Similarity: Contains 1 ubiquitin-like domain


    Find genes that share domains with UBQLN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with UBQLN3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBQLN3:
     Increased cell death HMECs cel  Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBQLN3
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    miRNA
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    miRTarBase miRNAs that target UBQLN3:
    hsa-mir-26b-5p (MIRT029449)

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    SwitchGear 3'UTR luciferase reporter plasmidUBQLN3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBQLN3 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with UBQLN3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for UBQLN3):
        Protein processing in endoplasmic reticulum

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBQLN3
    Interactions:

        Search GeneGlobe Interaction Network for UBQLN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBQLN3 (ENSP000003479974) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD23AENSP000003213654STRING: ENSP00000321365
    RAD23BENSP000003507084STRING: ENSP00000350708
    PSMA4ENSP000000444624STRING: ENSP00000044462
    PSMC2ENSP000002926444STRING: ENSP00000292644
    PSMC3ENSP000002988524STRING: ENSP00000298852
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBQLN3 (UBQL3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBQLN3 gene: 
    NM_017481.2  

    Unigene Cluster for UBQLN3:

    Ubiquilin 3
    Hs.189184  [show with all ESTs]
    Unigene Representative Sequence: BC036743
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311659(uc001may.1) ENST00000445998
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat UBQLN3
      QuantiFast Probe-based Assays in human, mouse, rat UBQLN3

    Additional mRNA sequence: 

    AF230481.1 BC036743.1 

    2 DOTS entries:

    DT.100686157  DT.40264831 

    Selected AceView cDNA sequences (see all 31):

    NM_017481 BC036743 BX098900 BM554226 BP370850 BM559772 BI828244 AI990809 
    BI831995 CD358097 AA628294 BG719475 BP371381 AF230481 BI520124 BI559461 
    BG720868 BG723394 CD360011 BI830050 BI559998 BF979648 BI562365 AA927483 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for UBQLN3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for UBQLN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBQLN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTTTCTGA
    UBQLN3 Expression
    About this image


    UBQLN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    UBQLN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBQLN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.189184

    UniProtKB/Swiss-Prot: UBQL3_HUMAN, Q9H347
    Tissue specificity: Testis specific

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBQLN3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubqln31 , 5 ubiquilin 31, 5 80.87(n)1
    74.05(a)1
      7 (54.85 cM)5
    2441781  NM_198623.21  NP_941025.11 
     1041406235 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    32(a)
    1 → many
    1(193662226-193663710) ENSGALG00000028406
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    28(a)
    1 → many
    GL343693.1(198380-211134)
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubqn6
    CG315286
    --
    37(a)
    27(a)
    many ↔ many
    many ↔ many
    X(19577781-19581273)
    3R(242160-243387)
    worm
    (Caenorhabditis elegans)
    Secernentea ubql-16
    Protein UBQL-1, isoform a
    34(a)
    1 → many
    I(7021982-7029076) WBGene00008852
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DSK26
    Nuclear-enriched ubiquitin-like polyubiquitin-bind...
    22(a)
    1 → many
    XIII(818827-819948) YMR276W


    ENSEMBL Gene Tree for UBQLN3 (if available)
    TreeFam Gene Tree for UBQLN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBQLN3 gene
    UBQLN22  UBQLN42  UBQLN12  UBQLNL2  
    2 SIMAP similar genes for UBQLN3 using alignment to 2 protein entries:     UBQL3_HUMAN (see all proteins):
    UBQLN1    UBQLN2

    Find genes that share paralogs with UBQLN3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBQLN3 (see all 217)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474929591,2
    --5528087(+) AAAGTC/TGGTAA 1 -- int10--------
    rs3177811,2
    C,F,O,A,H--5528177(-) AGCTTT/GCACTT 1 -- int134Minor allele frequency- G:0.36MN NS EA NA WA CSA 4828
    rs1124889211,2
    C,F--5528193(+) GGGGAC/TAGTCT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1438583441,2
    C--5528228(+) TATAAC/TCACTT 1 -- int10--------
    rs1143365451,2
    F--5528261(+) AGCTCG/AGAAAA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1472068751,2
    --5528314(+) AGAAAC/TGCTGA 1 -- int10--------
    rs1830916591,2
    --5528330(+) CACTGC/GGAAAG 1 -- int10--------
    rs1871058081,2
    --5528436(+) CAAGTA/CCTTCC 1 -- int10--------
    rs79297001,2
    C,F,H--5528561(+) CATCTC/GAAGAT 1 -- ut3113Minor allele frequency- G:0.06NS EA NA WA 1456
    rs10605741,2
    C,F,H--5528633(-) GTGCTA/GTGTGT 1 -- ut31 ese325Minor allele frequency- N:0.00MN EA NA NS WA 4234

    HapMap Linkage Disequilibrium report for UBQLN3 (5528530 - 5531215 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UBQLN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv896939CNV Loss21882294
    nsv832057CNV Loss17160897
    nsv510997CNV Complex20534489

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for UBQLN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605473    OMIM disorders: --


    Find genes that share disorders with UBQLN3           About GenesLikeMe


    Export disorders for UBQLN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBQLN3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with UBQLN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domain. (PubMed id 10831842)1, 2, 3, 9 Conklin D.... Feldhaus A.L. (Gene 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PubMed id 11121057)1, 2 Bulger M.... Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50613 HGNC: 12510 AceView: UBQLN3 Ensembl:ENSG00000175520 euGenes: HUgn50613
    ECgene: UBQLN3 Kegg: 50613 H-InvDB: UBQLN3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBQLN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBQLN3 gene:
    Search GeneIP for patents involving UBQLN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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