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Aliases for UBQLN3 Gene

Aliases for UBQLN3 Gene

  • Ubiquilin 3 2 3 5
  • Testicular Tissue Protein Li 220 3
  • Ubiquilin-3 3
  • TUP-1 3

External Ids for UBQLN3 Gene

Previous GeneCards Identifiers for UBQLN3 Gene

  • GC11M006276
  • GC11M005830
  • GC11M005487
  • GC11M005492
  • GC11M005188

Summaries for UBQLN3 Gene

Entrez Gene Summary for UBQLN3 Gene

  • This gene encodes a ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and are thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis. It has been suggested that this gene may regulate cell-cycle progression during spermatogenesis, however, it has been shown that the ortholgous mouse gene is dispensable for embryonic development and spermatogenesis. [provided by RefSeq, Nov 2016]

GeneCards Summary for UBQLN3 Gene

UBQLN3 (Ubiquilin 3) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is UBQLN1.

Additional gene information for UBQLN3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBQLN3 Gene

Genomics for UBQLN3 Gene

GeneHancer (GH) Regulatory Elements for UBQLN3 Gene

Promoters and enhancers for UBQLN3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I005509 Promoter 0.8 EPDnew 550.8 +0.0 18 0.1 ATF1 CREB1 ATF2 CREM UBQLN3 ENSG00000167355 OR51B5 HBG2
GH11I005518 Enhancer 0.4 FANTOM5 57.1 -8.6 -8555 0.1 ATF2 UBQLNL UBQLN3 OLFM5P HBG2
GH11I005516 Promoter 0.5 EPDnew 0.4 -6.7 -6734 0.1 UBQLNL OLFM5P UBQLN3 HBG2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBQLN3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBQLN3 gene promoter:

Genomic Locations for UBQLN3 Gene

Genomic Locations for UBQLN3 Gene
2,686 bases
Minus strand

Genomic View for UBQLN3 Gene

Genes around UBQLN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBQLN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBQLN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBQLN3 Gene

Proteins for UBQLN3 Gene

  • Protein details for UBQLN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q9NRE0

    Protein attributes for UBQLN3 Gene

    655 amino acids
    Molecular mass:
    70841 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG41675.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBQLN3 Gene

neXtProt entry for UBQLN3 Gene

Post-translational modifications for UBQLN3 Gene

No Post-translational modifications

Other Protein References for UBQLN3 Gene

No data available for DME Specific Peptides for UBQLN3 Gene

Domains & Families for UBQLN3 Gene

Gene Families for UBQLN3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for UBQLN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBQLN3: view

No data available for UniProtKB/Swiss-Prot for UBQLN3 Gene

Function for UBQLN3 Gene

genes like me logo Genes that share phenotypes with UBQLN3: view

miRNA for UBQLN3 Gene

miRTarBase miRNAs that target UBQLN3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBQLN3 Gene

Localization for UBQLN3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBQLN3 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for UBQLN3 Gene

Pathways & Interactions for UBQLN3 Gene

genes like me logo Genes that share pathways with UBQLN3: view

Pathways by source for UBQLN3 Gene

1 KEGG pathway for UBQLN3 Gene

Interacting Proteins for UBQLN3 Gene

Gene Ontology (GO) - Biological Process for UBQLN3 Gene


No data available for SIGNOR curated interactions for UBQLN3 Gene

Drugs & Compounds for UBQLN3 Gene

No Compound Related Data Available

Transcripts for UBQLN3 Gene

mRNA/cDNA for UBQLN3 Gene

Unigene Clusters for UBQLN3 Gene

Ubiquilin 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBQLN3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1: -

Relevant External Links for UBQLN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBQLN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBQLN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBQLN3 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for UBQLN3 Gene

This gene is overexpressed in Brain (28.1), Testis (24.9), Platelet (7.1), and Saliva (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UBQLN3 Gene

Protein tissue co-expression partners for UBQLN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBQLN3 Gene:


SOURCE GeneReport for Unigene cluster for UBQLN3 Gene:


mRNA Expression by UniProt/SwissProt for UBQLN3 Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with UBQLN3: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBQLN3 Gene

Orthologs for UBQLN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBQLN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBQLN3 33 34
  • 92.74 (n)
(Bos Taurus)
Mammalia UBQLN3 33 34
  • 84.2 (n)
(Canis familiaris)
Mammalia UBQLN3 33 34
  • 84.12 (n)
(Mus musculus)
Mammalia Ubqln3 33 16 34
  • 80.87 (n)
(Rattus norvegicus)
Mammalia Ubqln3 33
  • 80.66 (n)
(Monodelphis domestica)
Mammalia UBQLN3 34
  • 60 (a)
(Gallus gallus)
Aves -- 34
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ubqn 34
  • 37 (a)
CG31528 34
  • 27 (a)
(Caenorhabditis elegans)
Secernentea ubql-1 34
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DSK2 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10824 34
  • 34 (a)
Species where no ortholog for UBQLN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UBQLN3 Gene

Gene Tree for UBQLN3 (if available)
Gene Tree for UBQLN3 (if available)

Paralogs for UBQLN3 Gene

Paralogs for UBQLN3 Gene

(2) SIMAP similar genes for UBQLN3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UBQLN3: view

Variants for UBQLN3 Gene

Sequence variations from dbSNP and Humsavar for UBQLN3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000252841 -- 5,510,276(-) T/C upstream_transcript_variant
rs1000927466 -- 5,511,040(-) T/C upstream_transcript_variant
rs1001836136 -- 5,510,245(-) C/T upstream_transcript_variant
rs1002438801 -- 5,511,564(-) G/C upstream_transcript_variant
rs1003208400 -- 5,507,463(-) T/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for UBQLN3 Gene

Variant ID Type Subtype PubMed ID
esv3625230 CNV loss 21293372
esv3625232 CNV loss 21293372
nsv1046068 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv510997 OTHER complex 20534489
nsv553240 CNV loss 21841781
nsv553241 CNV gain 21841781
nsv832057 CNV loss 17160897

Variation tolerance for UBQLN3 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.05; 87.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBQLN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBQLN3 Gene

Disorders for UBQLN3 Gene

Additional Disease Information for UBQLN3

No disorders were found for UBQLN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBQLN3 Gene

Publications for UBQLN3 Gene

  1. Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domain. (PMID: 10831842) Conklin D … Feldhaus AL (Gene 2000) 2 3 4 22 58
  2. The ubiquilin gene family: evolutionary patterns and functional insights. (PMID: 24674348) Marín I (BMC evolutionary biology 2014) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M … Hardison R (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 58
  5. Ubqln3, a testis-specific gene, is dispensable for embryonic development and spermatogenesis in mice. (PMID: 25776854) Yuan S … Yan W (Molecular reproduction and development 2015) 3 58

Products for UBQLN3 Gene

Sources for UBQLN3 Gene

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