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Aliases for UBQLN3 Gene

Aliases for UBQLN3 Gene

  • Ubiquilin 3 2 3
  • TUP-1 3

External Ids for UBQLN3 Gene

Previous GeneCards Identifiers for UBQLN3 Gene

  • GC11M006276
  • GC11M005830
  • GC11M005487
  • GC11M005492
  • GC11M005188

Summaries for UBQLN3 Gene

Entrez Gene Summary for UBQLN3 Gene

  • Summary: This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis, and proposed to regulate cell-cycle progression during spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBQLN3 Gene

UBQLN3 (Ubiquilin 3) is a Protein Coding gene. Diseases associated with UBQLN3 include amyotrophic lateral sclerosis 1. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include binding. An important paralog of this gene is UBQLN1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBQLN3 Gene

Genomics for UBQLN3 Gene

Regulatory Elements for UBQLN3 Gene

Genomic Location for UBQLN3 Gene

Chromosome:
11
Start:
5,507,300 bp from pter
End:
5,509,985 bp from pter
Size:
2,686 bases
Orientation:
Minus strand

Genomic View for UBQLN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBQLN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBQLN3 Gene

Proteins for UBQLN3 Gene

  • Protein details for UBQLN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H347-UBQL3_HUMAN
    Recommended name:
    Ubiquilin-3
    Protein Accession:
    Q9H347
    Secondary Accessions:
    • Q9NRE0

    Protein attributes for UBQLN3 Gene

    Size:
    655 amino acids
    Molecular mass:
    70841 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG41675.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBQLN3 Gene

neXtProt entry for UBQLN3 Gene

Proteomics data for UBQLN3 Gene at MOPED

Post-translational modifications for UBQLN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBQLN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for UBQLN3 Gene

Domains & Families for UBQLN3 Gene

Gene Families for UBQLN3 Gene

Suggested Antigen Peptide Sequences for UBQLN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H347

UniProtKB/Swiss-Prot:

UBQL3_HUMAN :
  • Contains 1 STI1 domain.
Domain:
  • Contains 1 STI1 domain.
  • Contains 1 UBA domain.
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with UBQLN3: view

Function for UBQLN3 Gene

Gene Ontology (GO) - Molecular Function for UBQLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with UBQLN3: view
genes like me logo Genes that share phenotypes with UBQLN3: view

Animal Model Products

miRNA for UBQLN3 Gene

miRTarBase miRNAs that target UBQLN3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBQLN3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for UBQLN3 Gene

Localization for UBQLN3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBQLN3 Gene COMPARTMENTS Subcellular localization image for UBQLN3 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBQLN3 Gene

Pathways & Interactions for UBQLN3 Gene

genes like me logo Genes that share pathways with UBQLN3: view

Pathways by source for UBQLN3 Gene

1 KEGG pathway for UBQLN3 Gene

Interacting Proteins for UBQLN3 Gene

Gene Ontology (GO) - Biological Process for UBQLN3 Gene

None

No data available for SIGNOR curated interactions for UBQLN3 Gene

Drugs & Compounds for UBQLN3 Gene

No Compound Related Data Available

Transcripts for UBQLN3 Gene

mRNA/cDNA for UBQLN3 Gene

Unigene Clusters for UBQLN3 Gene

Ubiquilin 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBQLN3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBQLN3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1: -
SP2:

Relevant External Links for UBQLN3 Gene

GeneLoc Exon Structure for
UBQLN3
ECgene alternative splicing isoforms for
UBQLN3

Expression for UBQLN3 Gene

mRNA expression in normal human tissues for UBQLN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBQLN3 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for UBQLN3 Gene

This gene is overexpressed in Brain (28.1), Testis (24.9), Platelet (7.1), and Saliva (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UBQLN3 Gene



SOURCE GeneReport for Unigene cluster for UBQLN3 Gene Hs.189184

mRNA Expression by UniProt/SwissProt for UBQLN3 Gene

Q9H347-UBQL3_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with UBQLN3: view

Protein tissue co-expression partners for UBQLN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for UBQLN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBQLN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBQLN3 35
  • 84.2 (n)
  • 79.6 (a)
UBQLN3 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBQLN3 35
  • 84.12 (n)
  • 79.24 (a)
UBQLN3 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubqln3 35
  • 80.87 (n)
  • 74.05 (a)
Ubqln3 16
Ubqln3 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBQLN3 35
  • 92.74 (n)
  • 88.19 (a)
UBQLN3 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubqln3 35
  • 80.66 (n)
  • 74.96 (a)
oppossum
(Monodelphis domestica)
Mammalia UBQLN3 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31528 36
  • 27 (a)
ManyToMany
Ubqn 36
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ubql-1 36
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DSK2 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10824 36
  • 34 (a)
OneToMany
Species with no ortholog for UBQLN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UBQLN3 Gene

ENSEMBL:
Gene Tree for UBQLN3 (if available)
TreeFam:
Gene Tree for UBQLN3 (if available)

Paralogs for UBQLN3 Gene

Paralogs for UBQLN3 Gene

(2) SIMAP similar genes for UBQLN3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UBQLN3: view

Variants for UBQLN3 Gene

Sequence variations from dbSNP and Humsavar for UBQLN3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_020363 -
VAR_034578 -
VAR_052681 -
VAR_052682 -
VAR_052683 -

Structural Variations from Database of Genomic Variants (DGV) for UBQLN3 Gene

Variant ID Type Subtype PubMed ID
nsv832057 CNV Loss 17160897
nsv896939 CNV Loss 21882294
nsv510997 CNV Complex 20534489

Variation tolerance for UBQLN3 Gene

Residual Variation Intolerance Score: 95.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.05; 87.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBQLN3 Gene

HapMap Linkage Disequilibrium report
UBQLN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBQLN3 Gene

Disorders for UBQLN3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBQLN3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association

Relevant External Links for UBQLN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBQLN3
genes like me logo Genes that share disorders with UBQLN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBQLN3 Gene

Publications for UBQLN3 Gene

  1. Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domain. (PMID: 10831842) Conklin D. … Feldhaus A.L. (Gene 2000) 2 23 67
  2. The ubiquilin gene family: evolutionary patterns and functional insights. (PMID: 24674348) Marin I. (BMC Evol. Biol. 2014) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67
  5. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M. … Hardison R. (Proc. Natl. Acad. Sci. U.S.A. 2000) 67

Products for UBQLN3 Gene

Sources for UBQLN3 Gene

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