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Aliases for UBQLN2 Gene

Aliases for UBQLN2 Gene

  • Ubiquilin 2 2 3
  • CHAP1 3 4 6
  • PLIC2 3 4 6
  • Protein Linking IAP With Cytoskeleton 2 3 4
  • Ubiquitin-Like Product Chap1/Dsk2 3 4
  • ALS15 3 6
  • N4BP4 3 4
  • NEDD4 Binding Protein 4 2
  • Nedd4 Binding Protein 4 3
  • DSK2 Homolog 4
  • Ubiquilin-2 3
  • HRIHFB2157 3
  • HPLIC-2 4
  • PLIC-2 4
  • DSK2 3

External Ids for UBQLN2 Gene

Previous GeneCards Identifiers for UBQLN2 Gene

  • GC0XP053424
  • GC0XP054556
  • GC0XP055195
  • GC0XP055556
  • GC0XP056473
  • GC0XP053642

Summaries for UBQLN2 Gene

Entrez Gene Summary for UBQLN2 Gene

  • This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]

GeneCards Summary for UBQLN2 Gene

UBQLN2 (Ubiquilin 2) is a Protein Coding gene. Diseases associated with UBQLN2 include amyotrophic lateral sclerosis 15, with or without frontotemporal dementia and amyotrophic lateral sclerosis type 15. Among its related pathways are Protein processing in endoplasmic reticulum. An important paralog of this gene is UBQLN3.

UniProtKB/Swiss-Prot for UBQLN2 Gene

  • Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation.

Gene Wiki entry for UBQLN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBQLN2 Gene

Genomics for UBQLN2 Gene

Regulatory Elements for UBQLN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBQLN2 Gene

56,563,593 bp from pter
56,567,868 bp from pter
4,276 bases
Plus strand

Genomic View for UBQLN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBQLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBQLN2 Gene

Proteins for UBQLN2 Gene

  • Protein details for UBQLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O94798
    • Q5D027
    • Q9H3W6
    • Q9HAZ4

    Protein attributes for UBQLN2 Gene

    624 amino acids
    Molecular mass:
    65696 Da
    Quaternary structure:
    • Binds UBE3A and BTRC. Interacts with the 19S proteasome subunit. Interacts with C9orf72. Interacts with HNRNPA1 and HNRNPU (PubMed:25616961).

    Three dimensional structures from OCA and Proteopedia for UBQLN2 Gene

neXtProt entry for UBQLN2 Gene

Proteomics data for UBQLN2 Gene at MOPED

Post-translational modifications for UBQLN2 Gene

  • Ubiquitination at Lys41, Lys43, Lys66, and Lys79
  • Modification sites at PhosphoSitePlus

Other Protein References for UBQLN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UBQLN2 (UBQLN2)

No data available for DME Specific Peptides for UBQLN2 Gene

Domains for UBQLN2 Gene

Gene Families for UBQLN2 Gene

Suggested Antigen Peptide Sequences for UBQLN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 UBA domain.
  • Contains 1 UBA domain.
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with UBQLN2: view

Function for UBQLN2 Gene

Molecular function for UBQLN2 Gene

UniProtKB/Swiss-Prot Function:
Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation.
UniProtKB/Swiss-Prot Induction:
Highly expressed in mitotic cells from metaphase to telophase. Expression in non-mitotic cells is very low

Gene Ontology (GO) - Molecular Function for UBQLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003684 damaged DNA binding --
GO:0005488 binding --
GO:0005515 protein binding IPI 17098253
genes like me logo Genes that share ontologies with UBQLN2: view

Phenotypes for UBQLN2 Gene

GenomeRNAi human phenotypes for UBQLN2:
genes like me logo Genes that share phenotypes with UBQLN2: view

Animal Model Products

miRNA for UBQLN2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBQLN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for UBQLN2 Gene

Localization for UBQLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBQLN2 Gene

Cytoplasm. Nucleus. Note=Where it colocalizes with the proteasome. Associated with fibers in mitotic cells.

Subcellular locations from

Jensen Localization Image for UBQLN2 Gene COMPARTMENTS Subcellular localization image for UBQLN2 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for UBQLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with UBQLN2: view

Pathways for UBQLN2 Gene

genes like me logo Genes that share pathways with UBQLN2: view

Pathways by source for UBQLN2 Gene

1 KEGG pathway for UBQLN2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for UBQLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006289 nucleotide-excision repair --
GO:0008219 cell death --
GO:0016241 regulation of macroautophagy IMP 20529957
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process --
GO:2000785 regulation of autophagic vacuole assembly IMP 20529957
genes like me logo Genes that share ontologies with UBQLN2: view

Transcripts for UBQLN2 Gene

mRNA/cDNA for UBQLN2 Gene

(62) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UBQLN2 Gene

Ubiquilin 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBQLN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBQLN2 Gene

No ASD Table

Relevant External Links for UBQLN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBQLN2 Gene

mRNA expression in normal human tissues for UBQLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for UBQLN2 Gene

This gene is overexpressed in Bone (24.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBQLN2 Gene

SOURCE GeneReport for Unigene cluster for UBQLN2 Gene Hs.179309

genes like me logo Genes that share expressions with UBQLN2: view

Expression partners for UBQLN2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBQLN2 Gene

Orthologs for UBQLN2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBQLN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UBQLN2 35
  • 92.36 (n)
  • 96.47 (a)
  • 96 (a)
(Canis familiaris)
Mammalia UBQLN2 35
  • 93.14 (n)
  • 97.27 (a)
  • 97 (a)
(Mus musculus)
Mammalia Ubqln2 35
  • 86.1 (n)
  • 88.89 (a)
Ubqln2 16
Ubqln2 36
  • 87 (a)
(Pan troglodytes)
Mammalia UBQLN2 35
  • 99.79 (n)
  • 99.84 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ubqln2 35
  • 86.21 (n)
  • 87.76 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
-- 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
(Gallus gallus)
Aves -- 36
  • 75 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14224 37
  • 48 (a)
CG31528 36
  • 28 (a)
Ubqn 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea ubql-1 35
  • 49.02 (n)
  • 41.99 (a)
ubql-1 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DSK2 36
  • 29 (a)
DSK2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons DSK2 35
  • 48.49 (n)
  • 44.19 (a)
(Oryza sativa)
Liliopsida Os10g0542200 35
  • 48.76 (n)
  • 43.46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10824 36
  • 48 (a)
Species with no ortholog for UBQLN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UBQLN2 Gene

Gene Tree for UBQLN2 (if available)
Gene Tree for UBQLN2 (if available)

Paralogs for UBQLN2 Gene

Paralogs for UBQLN2 Gene

(3) SIMAP similar genes for UBQLN2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBQLN2: view

Variants for UBQLN2 Gene

Sequence variations from dbSNP and Humsavar for UBQLN2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs383604 -- 56,563,346(+) CAGAA(A/G)CTGAC upstream-variant-2KB
rs3174412 -- 56,566,801(+) CTTTC(A/C)CTGAA utr-variant-3-prime
rs140167423 -- 56,565,148(+) GAGCA(G/T)ATGCG reference, missense
rs146254628 -- 56,563,309(+) TAATA(C/T)ACATT upstream-variant-2KB
rs148135031 -- 56,564,731(+) GAGCA(G/T)TTTGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for UBQLN2 Gene

Variant ID Type Subtype PubMed ID
nsv6916 CNV Loss 18451855
nsv510538 CNV Loss 20534489

Relevant External Links for UBQLN2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBQLN2 Gene

Disorders for UBQLN2 Gene

(1) OMIM Diseases for UBQLN2 Gene (300264)


  • Amyotrophic lateral sclerosis 15, with or without frontotemporal dementia (ALS15) [MIM:300857]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Patients with ALS15 may develop frontotemporal dementia. {ECO:0000269 PubMed:21857683, ECO:0000269 PubMed:22560112, ECO:0000269 PubMed:22717235, ECO:0000269 PubMed:22892309, ECO:0000269 PubMed:25616961}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with UBQLN2: view

No data available for Novoseek inferred disease relationships , Genatlas and External Links for UBQLN2 Gene

Publications for UBQLN2 Gene

  1. The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. (PMID: 10983987) Kleijnen M.F. … Howley P.M. (Mol. Cell 2000) 3 4 23
  2. Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a. (PMID: 11827521) Walters K.J. … Howley P.M. (Biochemistry 2002) 3 4 23
  3. A family of ubiquitin-like proteins binds the ATPase domain of Hsp70- like Stch. (PMID: 10675567) Kaye F.J. … Rose M.D. (FEBS Lett. 2000) 2 3 4
  4. Identification of ubiquitin-like protein-binding subunits of the 26S proteasome. (PMID: 12200120) Saeki Y. … Yokosawa H. (Biochem. Biophys. Res. Commun. 2002) 3 23
  5. The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis. (PMID: 18199683) N'Diaye E.N. … Brown E.J. (Mol. Biol. Cell 2008) 3 23

Products for UBQLN2 Gene

Sources for UBQLN2 Gene

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