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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UBQLN1 Gene

protein-coding GIFtS: 60
GCID: GC09M086274

ubiquilin 1

Explore 18 diseases affiliated with
UBQLN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ubiquilin 1¹ ²		Protein Linking IAP With Cytoskeleton 1² ³
DA41¹ ² ³ ⁵		HPLIC-1¹
PLIC-1¹ ² ³		UBQN²
DSK2¹ ²		Ubiquilin-1¹
XDRP1¹ ²		PLIC1³

External Ids:	HGNC: 12508¹	Entrez Gene: 29979²	Ensembl: ENSG00000135018⁷	OMIM: 605046⁵	UniProtKB: Q9UMX0³

Export aliases for UBQLN1 gene to outside databases

Previous GC identifers: GC09M077319 GC09M078129 GC09M079829 GC09M081731 GC09M081732 GC09M083504 GC09M085464 GC09M056100

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBQLN1:

This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products

in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated

domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally

link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also

been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and

Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UBQL1_HUMAN, Q9UMX0

Function: Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes

the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2

degradation

Gene Wiki entry for UBQLN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UBQLN1 gene promoter:
RORalpha1 AhR Pax-3 Pbx1a FOXD3 Chx10 CUTL1 Nkx2-5 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBQLN1 promoter sequence

Search SABiosciences Chromatin IP Primers for UBQLN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBQLN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22|9q21.2-q21.3 Ensembl cytogenetic band: 9q21.32 HGNC cytogenetic band: 9q22

UBQLN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBQLN1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M086274: view genomic region (about GC identifiers)

Start:	86,274,878 bp from pter	End:	86,323,168 bp from pter
Size:	48,291 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UBQL1_HUMAN, Q9UMX0 (See protein sequence)

Recommended Name: Ubiquilin-1

Size: 589 amino acids; 62519 Da

Subunit: Binds CD47, NBL1, GABRA1, GABRA2, GABRA3, GABRA6, GABRB1, GABRB2 and GABRB3 (By similarity). Binds UBE3A,

BTRC, P4HB, MTOR, PSEN1 and PSEN2. Interacts with the proteasome 19S subunit

Subcellular location: Cytoplasm. Nucleus

3 PDB 3D structures from and Proteopedia for UBQLN1:

2JY5 (3D)

2JY6 (3D)

2KLC (3D)

Secondary accessions: Q5T6J5 Q5T6J9 Q8IXS9 Q8N2Q3 Q9H0T8 Q9H3R4 Q9HAZ5

Alternative splicing: 2 isoforms: Q9UMX0-1 Q9UMX0-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBQLN1: NX_Q9UMX0

Post-translational modifications:

Phosphorylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UMX0

UBQLN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_038466.2 NP_444295.1

ENSEMBL proteins:

ENSP00000365576 ENSP00000257468 ENSP00000436912 ENSP00000434194

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for UBQLN1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IMP	12634373
GO:0005783	endoplasmic reticulum	IDA	12095988
GO:0043234	protein complex	IDA	--

UBQLN1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UBQLN1 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR006636 STI1_HS-bd

IPR000449 UBA/transl_elong_EF1B_N

IPR015940 UBA/transl_elong_EF1B_N_euk

IPR015496 Ubiquilin

IPR000626 Ubiquitin

Graphical View of Domain Structure for InterPro Entry Q9UMX0

ProtoNet protein and cluster: Q9UMX0

2 Blocks protein families:

IPB000449 Ubiquitin-associated domain

IPB000626 Ubiquitin domain

UniProtKB/Swiss-Prot: UBQL1_HUMAN, Q9UMX0

Domain: Binds PSEN1 and PSEN2 via its UBA domain

Similarity: Contains 1 UBA domain

Similarity: Contains 1 ubiquitin-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: UBQL1_HUMAN, Q9UMX0

Function: Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes

the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2

degradation

miRNA Products:		miRTarBase miRNAs that target UBQLN1: hsa-mir-210 (MIRT003156)

		OriGene 3'-UTR Clone (see all 2): UBQLN1 Browse MicroRNA Expression Plasmids
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		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate UBQLN1 (see all 17):
		hsa-miR-623 hsa-miR-429 hsa-miR-1257 hsa-miR-298 hsa-miR-3613-3p hsa-miR-3143 hsa-miR-1208 hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: UBQLN1 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBQLN1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12095988
GO:0019900	kinase binding	IPI	11853878
GO:0019904	protein domain specific binding	--	--

UBQLN1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Protein processing in endoplasmic reticulum

Protein processing in endoplasmic reticulum

1.00

CXCR4-mediated signaling events

CXCR4-mediated signaling events

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for UBQLN1

CXCR4-mediated signaling events

1 Kegg Pathway (Kegg details for UBQLN1):

Protein processing in endoplasmic reticulum

UBQLN1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for UBQLN1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/118 Interacting proteins for UBQLN1 (Q9UMX0^{2, 3} ENSP00000365576⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 118)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PSMD4	P55036²^,³, ENSP00000357879⁴	MINT-7307732 MINT-7307918 MINT-7307827 MINT-7307801 MINT-7307892 MINT-4300148 I2D: score=5 STRING: ENSP00000357879
ADRM1	Q16186²^,³, ENSP00000253003⁴	MINT-7308816 MINT-7308237 MINT-7308834 I2D: score=3 STRING: ENSP00000253003
PSEN1	P49768²^,³, ENSP00000326366⁴	MINT-16889 MINT-16890 MINT-16888 I2D: score=3 STRING: ENSP00000326366
ATXN3	P54252²^,³, ENSP00000352324⁴	MINT-4300171 MINT-4300075 I2D: score=3 STRING: ENSP00000352324
RIC8A	Q9NPQ8²^,³, ENSP00000325941⁴	MINT-67642 I2D: score=6 STRING: ENSP00000325941

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IMP	12095988
GO:0006915	apoptotic process	IMP	12095988
GO:0031396	regulation of protein ubiquitination	IDA	12634373

UBQLN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

UBQLN1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UBQLN1
1 Novoseek chemical compound relationship for UBQLN1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glutamine	14.1	1	17082820 (1)

Search CenterWatch for drugs/clinical trials and news about UBQLN1 / UBQL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UBQLN1 gene (2 alternative transcripts):

NM_013438.4 NM_053067.2

Unigene Cluster for UBQLN1:

Ubiquilin 1

Hs.9589 [show with all ESTs]

Unigene Representative Sequence: AB209468

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376395(uc004amv.3 uc004amw.3) ENST00000533705 ENST00000257468

ENST00000526134 ENST00000527373 ENST00000529923

miRNA Products:		OriGene 3'-UTR Clone (see all 2): UBQLN1 Browse OriGene MicroRNA Expression Plasmids
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		hsa-miR-623 hsa-miR-429 hsa-miR-1257 hsa-miR-298 hsa-miR-3613-3p hsa-miR-3143 hsa-miR-1208 hsa-miR-200b

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Additional cDNA sequence:

AB035275.1 AB209468.1 AF176069.3 AF293384.1 AK027556.1 AK027576.1 AK074535.1 AK125815.1

AL136643.1 BC010066.2 BC039294.1

15 DOTS entries:

DT.100036812 DT.443588 DT.100036814 DT.100825284 DT.40118719 DT.40241331 DT.121201647 DT.92448341

DT.95173203 DT.100825281 DT.121201600 DT.121201624 DT.92448346 DT.95173192 DT.95173194

24/426 AceView cDNA sequences (see all 426):

W68561 AA488984 T53178 AF176069 AA843067 AW474532 BG387774 AW418815

BM463321 CB157819 AI392898 AA287729 BQ220631 BE217741 BX956459 AI379212

AW770944 AL520071 AI796994 BE672920 N90838 CD679359 AW137986 BC039294

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for UBQLN1 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b
SP1:																					-				-
SP2:																			-		-				-
SP3:					-		-		-
SP4:																									-
SP5:

ECgene alternative splicing isoforms for UBQLN1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UBQLN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCTTTGCT

About this image
See UBQLN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBQLN1

SOURCE GeneReport for Unigene cluster: Hs.9589

UniProtKB/Swiss-Prot: UBQL1_HUMAN, Q9UMX0

Tissue specificity: Ubiquitous. Highly expressed throughout the brain; detected in neurons and in neuropathological

lesions, such as neurofibrillary tangles and Lewy bodies. Highly expressed in heart, placenta, pancreas, lung, liver,

skeletal muscle and kidney

SABiosciences Expression via Pathway-Focused PCR Array including UBQLN1:

Alzheimer's Disease in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBQLN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBQLN1 gene from 9/32 species (see all 32) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ubqln1^{1 , 5}	ubiquilin 1^{1, 5}	85.26(n)¹ 90.5(a)¹		13 (30.95 cM)⁵ 56085¹ NM_026842.4¹ NP_081118.4¹ 58176156⁵
chicken (Gallus gallus)	Aves	UBQLN1¹	ubiquilin 1	78.11(n) 83.19(a)		427454 XM_425028.2 XP_425028.2
lizard (Anolis carolinensis)	Reptilia	--	--	81(a)	1 ↔ 1	2(42676593-42701741)
tropical clawed frog (Xenopus tropicalis)	Amphibia	MGC75576²	hypothetical protein MGC75576	80.14(n)		BC063190.1
fruit fly (Drosophila melanogaster)	Insecta	CG14224³ Ubqn¹	Ubiquilin¹	46(a)³ 53.84(n)¹ 55.71(a)¹		18E1³ 32977¹ NM_134500.3¹ NP_608344.1¹
worm (Caenorhabditis elegans)	Secernentea	ubql-1¹	Protein UBQL-1	51.18(n) 43.61(a)		172434 NM_170894.2 NP_740883.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	DSK2¹	Dsk2p	43.95(n) 33.12(a)		855319 NP_014003.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G17190¹	ubiquilin	46.99(n) 42(a)		816224 NM_127273.3 NP_565407.1
rice (Oryza sativa)	Liliopsida	Os10g0542200¹	hypothetical protein	48.61(n) 42.91(a)		4349264 NM_001071728.1 NP_001065193.1

ENSEMBL Gene Tree for UBQLN1 (if available)
TreeFam Gene Tree for UBQLN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for UBQLN1 gene

UBQLN3² UBQLN2² UBQLN4² UBQLNL²

3 SIMAP similar genes for UBQLN1 using alignment to 3 protein entries: UBQL1_HUMAN (see all proteins):

UBQLN2 UBQLN4 UBQLN3

UBQLN1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for UBQLN1
PGOHUM00000243136

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1044256^1,2		--	56100455(-)	`CTGTTC/TTGACA`	2	--	ut3¹		0	--	--	--	--
rs73476336^1,2	C,	--	56100654(+)	`TCAGCC/TAAATG`	2	--	ut3¹		2		WA	120
rs12404^1,2		--	56101755(-)	`GTCCAG/CTTTAT`	2	--	ut3¹		4		MN NA WA	306
rs11659^1,2	C,F,H,	--	56101921(+)	`AAATGC/TATCAT`	2	--	ut3¹ ese³		11		MN NS EA NA WA	1396
rs79530639^1,2	C,	--	56102183(+)	`ATCTGA/GCTTCT`	4	A V	mis¹		0	--	--	--	--
rs60734573^1,2	C,F,	--	56102362(+)	`AGTCCA/TTTAGC`	2	--	int¹		1		WA	118
rs75865570^1,2		--	56102765(+)	`CATCAA/TATCTT`	2	--	int¹		0	--	--	--	--
rs113362574^1,2		--	56103241(+)	`TGCAGT/CCCAGG`	2	--	int¹		1		CSA	1
rs200100152^1,2	C	--	56103313(+)	`GGAAAA/GAAAAA`	2	--	int¹		0	--	--	--	--
rs71502717^1,2	C	--	56103386(+)	`AAGGGT/AAAAGG`	2	--	int¹		1		NA	2

HapMap Linkage Disequilibrium report for UBQLN1 (86274878 - 86323168 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBQLN1: --
Human Gene Mutation Database (HGMD): UBQLN1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

UBQLN1 for disorders           About GeneDecksing

OMIM gene information: 605046    OMIM disorders: --

18 diseases for UBQLN1:    About MalaCards

parkinson's disease amyotrophic lateral sclerosis (als) amyotrophic lateral sclerosis lateral sclerosis

neurodegenerative disease alzheimer's disease hepatitis c huntington's disease

lung adenocarcinoma neurodegeneration dementia adenocarcinoma

ataxia hepatitis hypoxia neuroblastoma

malaria neuronitis

2 diseases from the University of Copenhagen DISEASES database for UBQLN1:

Alzheimer's disease Brown-Vialetto-Van Laere syndrome

3 Novoseek disease relationships for UBQLN1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	68	19	15745979 (5), 16214290 (2), 17704509 (1), 18340109 (1) (see all 10)
neurodegenerative diseases	43.4	1	19772837 (1)
tumors	0	1	10807547 (1)

Genetic Association Database (GAD): UBQLN1
Human Genome Epidemiology (HuGE) Navigator: UBQLN1 (11 documents)

Export disorders for UBQLN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for UBQLN1 gene, integrated from 9 sources (see all 103):
(articles sorted by number of sources associating them with UBQLN1)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3. (PubMed id 10807547)^{1, 2, 3, 9} Hanaoka E.... Sakiyama S. (2000)
Genetic association of ubiquilin with Alzheimer's disease and related quantitative measures. (PubMed id 16302009)^{1, 4, 9} Kamboh M.I....DeKosky S.T. (2006)
The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not associated with Alzheimer's disease with onset before 70 years. (PubMed id 16214290)^{1, 4, 9} Brouwers N....Dermaut B. (2006)
Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. (PubMed id 16278862)^{1, 4, 9} Smemo S....Goate A. (2006)
The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. (PubMed id 10983987)^{1, 2, 9} Kleijnen M.F.... Howley P.M. (2000)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death. (PubMed id 12095988)^{1, 2} Ko H.S.... Nomura Y. (2002)
Characterization of ubiquilin 1, an mTOR-interacting protein. (PubMed id 11853878)^{1, 2} Wu S.... Avruch J. (2002)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 29979	HGNC: 12508	AceView: UBQLN1	Ensembl:ENSG00000135018	euGenes: HUgn29979
ECgene: UBQLN1	Kegg: 29979	H-InvDB: UBQLN1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for UBQLN1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UBQLN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for UBQLN1 gene:
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GeneCards and IP:
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