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UBQLN1 Gene

protein-coding GIFtS: 62

GC09M085464

ubiquilin 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DA41 ^¹, ², ³, ⁵
DSK2 ^¹, ²
FLJ90054 ^²
OTTHUMP00000021544 ^²
OTTHUMP00000021545 ^²
PLIC-1 ^¹, ², ³
PLIC1 ^³
UBQN ^²
XDRP1 ^¹, ²
hPLIC-1 ^³

Descriptions
Protein linking IAP with cytoskeleton 1 ^³
ubiquilin 1 ^²

External Ids
HGNC: 12508¹
Entrez Gene: 29979²
UniProtKB: Q9UMX0³
Ensembl: ENSG00000135018⁷

Search outside databases for aliases for UBQLN1 gene

Previous GC identifers: GC09M077319 GC09M078129 GC09M079829 GC09M081731 GC09M081732 GC09M083504

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBQLN1:

This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity

with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like

domain and a C-terminal ubiquitin-associated domain. They physically associate with both

proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination

machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been

shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with

Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms

have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBQL1_HUMAN, Q9UMX0

Function: Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By

similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their

biosynthesis. Has no effect on PSEN1 and PSEN2 degradation

Gene Wiki entry for UBQLN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBQLN1 gene

Entrez Gene cytogenetic band: 9q22|9q21.2-q21.3 Ensembl cytogenetic band: 9q21.32 HGNC cytogenetic band: 9q22

UBQLN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M085464: (about GC identifiers)

Start:	85,464,699 bp from pter
End:	85,512,773 bp from pter
Size:	48,075 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_023935.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBQL1_HUMAN, Q9UMX0 (See protein sequence)

Recommended Name: Ubiquilin-1

Size: 589 amino acids; 62519 Da

Subunit: Binds CD47, NBL1, GABRA1, GABRA2, GABRA3, GABRA6, GABRB1, GABRB2 and GABRB3 (By

similarity). Binds UBE3A, BTRC, P4HB, FRAP1, PSEN1 and PSEN2. Interacts with the proteasome 19S

subunit

Subcellular location: Cytoplasm. Nucleus

PDB structure from and Proteopedia :

2JY5 (3D)

2JY6 (3D)

Secondary accessions: Q8IXS9 Q8N2Q3 Q9H0T8 Q9H3R4 Q9HAZ5

Alternative splicing: 2 isoforms: Q9UMX0-1 Q9UMX0-2

Post-translational modifications:

Phosphorylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_038466.2 NP_444295.1

ENSEMBL proteins:

ENSP00000365576 ENSP00000257468

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for UBQLN1
	Recombinant Proteins from Abcam (Ubiquilin)
	Human Recombinant Proteins from Abnova (UBQLN1)

OriGene Purified Recombinant Human Protein: UBQLN1

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	11853878
GO:0005829	cytosol	IEA	--
GO:0043234	protein complex	IEA	--
GO:0048471	perinuclear region of cytoplasm	NAS	11853878

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Antibodies for UBQLN1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for UBQLN1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Ubiquilin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBQLN1)
	Novus Biologicals Antibodies for UBQLN1

Assays for UBQLN1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9UMX0

ProtoNet protein and cluster: Q9UMX0

2 Blocks protein families:

IPB000449 Ubiquitin-associated domain

IPB000626 Ubiquitin domain

UniProtKB/Swiss-Prot: UBQL1_HUMAN, Q9UMX0

Domain: Binds PSEN1 and PSEN2 via its UBA domain

Similarity: Contains 1 UBA domain

Similarity: Contains 1 ubiquitin-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBQLN1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBQLN1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_013438

Applied Biosystems Silencer® siRNAs for UBQLN1

Sigma-Aldrich siRNA and siRNA Panels for UBQLN1

Sigma-Aldrich shRNA Panels and shRNA for UBQLN1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for UBQLN1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_013438
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_013438
untagged cDNA clones in CMV expression vector (see all 3): NM_013438

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_013438

UniProtKB/Swiss-Prot: UBQL1_HUMAN, Q9UMX0

Function: Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By

similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their

biosynthesis. Has no effect on PSEN1 and PSEN2 degradation

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019900	kinase binding	IPI	11853878

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for UBQLN1 (Your Favorite Gene powered by Ingenuity)

GABA Receptor Signaling

GeneDecks UBQLN1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for UBQLN1

5/40 Interacting proteins for UBQLN1 (ENSP00000365576³ Q9UMX0²) via UniProtKB, MINT, and/or STRING (see all 40 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EPS15	P42566²	STRING (score=.773) MINT-4300195 MINT-4300120 MINT-4302859 MINT-4302787 MINT-4302826
PSEN1	P49768²	STRING (score=.983) MINT-16889 MINT-16890 MINT-16888
PSEN2	P49810²	STRING (score=.98) MINT-17616 MINT-17615 MINT-17617
ATXN3	P54252²	STRING (score=.73) MINT-4300171 MINT-4300075
PSMD4	P55036²	STRING (score=.782) MINT-4300148

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006464	protein modification process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBQLN1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBQLN1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBQLN1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_013438

Sigma-Aldrich siRNA and siRNA Panels for UBQLN1

Sigma-Aldrich shRNA Panels and shRNA for UBQLN1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_013438 NM_053067

REFSEQ mRNAs for UBQLN1 gene (2 alternative transcripts):

NM_013438.4 NM_053067.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_013438 NM_053067

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_013438
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_013438
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_013438

Additional cDNA sequence:

AB035275.1 AB209468.1 AF176069.3 AF293384.1 AK027556.1 AK027576.1 AK074535.1 AK125815.1

AL136643.1 BC010066.2 BC039294.1 CR596552.1 CR612259.1

14 DOTS entries:

DT.100036812 DT.443588 DT.100036814 DT.100825284 DT.40118719 DT.40241331 DT.121201647 DT.92448341

DT.95173203 DT.100825281 DT.121201600 DT.121201624 DT.92448346 DT.95173192

24/426 AceView cDNA sequences (see all 426 ):

AV725590 AA749374 BF590799 AI738847 BE219910 AI989901 CD106908 BG387774

AW474532 AI701397 BG528770 BE672920 AW572006 AI738564 N90838 AI568787

NM_013438 Z17365 BQ008742 CA432340 CD679359 AI796994 AI658751 AA021505

highest scoring ESTs for UBQLN1:

AI244901 AA016215 AA021506 AA037649 AA160015 AA313336 AA452806 AA576689 AA749374 AA758246

Unigene Cluster for UBQLN1:

Ubiquilin 1

Hs.9589 [show with all ESTs]

Unigene Representative Sequence: AB209468

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for UBQLN1

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b
SP1:																					-				-
SP2:																			-		-				-
SP3:					-		-		-
SP4:																									-
SP5:

About this scheme

ECgene alternative splicing isoforms for UBQLN1

2 Ensembl transcripts including schematic representations:

ENST00000376395 ENST00000257468

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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UBQLN1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBQLN1

¹ / ² / ³

9 probe-sets matching UBQLN1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
82573_at²^{, 3}	U95-E	1	1.00	1.00	0.87	1.08	AI244901	1.00	1.00	1.00	1
46707_at²^{, 3}	U95-B	1	1.00	1.00	0.32	1.12	N90555	0.80	1.00	0.91	1
57914_at²^{, 3}	U95-B	1	0.88	1.00	0.93	0.79	W52859	0.80	1.00	0.91	1
222991_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL136643	0.80	0.88	0.84	1
222989_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	NM_013438	0.60	1.00	0.82	1
222990_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW204104	0.60	1.00	0.82	1
222991_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222989_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222990_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTCTTTGCT

SOURCE GeneReport for Unigene cluster: Hs.9589
UniProtKB/Swiss-Prot: UBQL1_HUMAN, Q9UMX0
Tissue specificity: Ubiquitous. Highly expressed throughout the brain; detected in neurons and in
neuropathological lesions, such as neurofibrillary tangles and Lewy bodies. Highly expressed in
heart, placenta, pancreas, lung, liver, skeletal muscle and kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for UBQLN1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBQLN1¹	--	ubiquilin 1	93.6(n) 95.76(a)	476312 XM_853208.1 XP_858301.1
cow (Bos taurus)	UBQLN1¹	--	ubiquilin 1	92.28(n) 94.72(a)	282392 NM_174628.1 NP_777053.1
rat (Rattus norvegicus)	Ubqln1¹	--	ubiquilin 1	84.28(n) 88.95(a)	114590 NM_053747.2 NP_446199.2
mouse (Mus musculus)	Ubqln1^{1, 5}	13 (35.00 cM)⁵	ubiquilin 1^{1, 5}	84.45(n)¹ 90.02(a)¹	56085¹ NM_152234.1¹ NP_689420.1¹ AF177345⁵ AI425982⁵ (see all 34)
chicken (Gallus gallus)	UBQLN1¹	--	ubiquilin 1	78.11(n) 83.19(a)	427454 XM_425028.2 XP_425028.2

About this table Species with no ortholog for UBQLN1

ENSEMBL Gene Tree for UBQLN1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for UBQLN1 gene

UBQLN3² UBQLN2² UBQLN4² UBQLNL²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/319 NCBI SNPs in UBQLN1 are shown (see all 319 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 123)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1333863^1,2	A,C,F,H,O	85513802(-)	`AGAAAC/GGCAGA`	2	--	ng3¹		14	NA EA MN EU WA	1096
	rs1333865^1,2	A,C,F,H,O	85513416(-)	`CAGGTC/TGCCTG`	2	--	ng3¹		20	NA EA MN EU WA	2922
	rs2811928^1,2	A,C,F,H	85464663(+)	`TTAAAT/GACTTT`	1	--	ng5¹		4	EU EA WA	418
	rs1333862^1,2	A,C,F,H	85514070(-)	`AATGAT/CTGGTT`	2	--	ng3¹ tfbs³		14	NA EA EU WA	1090
	rs7874980^1,2	A,C,F,H	85514724(+)	`agtaaC/Tcatag`	1	--	ng3¹		4	EU EA WA	420
	rs3814507^1,2	A,C,F,H	85513129(+)	`CTTGCC/TTCTCT`	2	--	ng3¹		6	MN EA EU WA	1670
	rs3814505^1,2	A,C,F,H	85512977(+)	`TCACGA/GTTAGC`	2	--	ut5¹ tfbs³		6	MN EA EU WA	1670
	rs12345514^1,2	A,C,F,H	85514246(+)	`ATCCTG/TTATCA`	2	--	ng3¹		4	EU EA WA	414
	rs1044214^1,2	A,C,F,H	85465379(-)	`GTCCTG/TGATGG`	2	--	ut3¹		5	MN EU EA WA	602
	rs3814506^1,2	C,F,H	85513094(+)	`CC/TTCCGC`	2	--	ng3¹		3	EA WA	298

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HapMap Linkage Disequilibrium images for UBQLN1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 605046

2 Novoseek disease relationships for UBQLN1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	68.49	18	15745979 (5), 16214290 (2), 17704509 (1), 16278862 (1) (see all 9)
tumors	0.00	1	10807547 (1)

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Genetic Association Database: UBQLN1
Human Genome Epidemiology Navigator: UBQLN1 (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/57 PubMed articles for UBQLN1 gene (see all 57 ):

Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3. (PubMed id 10807547)^{1, 2, 3, 4} Hanaoka E....Sakiyama S. (2000)
Genetic association of ubiquilin with Alzheimer's disease and related quantitative measures. (PubMed id 16302009)^{1, 3, 6} Kamboh M.I....DeKosky S.T. (2006)
Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. (PubMed id 16278862)^{1, 3, 6} Smemo S....Goate A. (2006)
The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not associated with Alzheimer's disease with onset before 70 years. (PubMed id 16214290)^{1, 3, 6} Brouwers N....Dermaut B. (2006)
The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. (PubMed id 10983987)^{1, 3, 4} Kleijnen M.F.... Howley P.M. (2000)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death. (PubMed id 12095988)^{3, 4} Ko H.S.... Nomura Y. (2002)
Characterization of ubiquilin 1, an mTOR-interacting protein. (PubMed id 11853878)^{3, 4} Wu S.... Avruch J. (2002)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{3, 4} Wiemann S.... Poustka A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 29979	HGNC: 12508	AceView: UBQLN1	Ensembl:ENSG00000135018	euGenes: HUgn29979
ECgene: UBQLN1	H-InvDB: UBQLN1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for UBQLN1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UBQLN1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBQLN1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBQLN1		Antibodies for UBQLN1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UBQLN1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Antibodies (Ubiquilin)

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Search Tocris compounds for UBQLN1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
UBQLN1 Gene at Home site.
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UBQLN1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for UBQLN1

Summaries
for UBQLN1

Genomic Location
for UBQLN1

Proteins
for UBQLN1

Protein Domains/
Families
for UBQLN1

Gene Function
for UBQLN1

Pathways & Interactions
for UBQLN1

Drugs & Compounds
for UBQLN1

Transcripts
for UBQLN1

Expression
for UBQLN1

Orthologs
for UBQLN1

Paralogs
for UBQLN1

SNPs/Variants
for UBQLN1

Disorders & Mutations
for UBQLN1

Medical News
for UBQLN1

Publications
for UBQLN1

Search for UBQLN1

Genome Databases showing UBQLN1

Other Databases showing UBQLN1

Specialized Databases showing UBQLN1

Licensable Technologies
for UBQLN1

Services
for UBQLN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBQLN1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor UBQLN1

Summariesfor UBQLN1

Genomic Locationfor UBQLN1

Proteinsfor UBQLN1

Protein Domains/Familiesfor UBQLN1

Gene Functionfor UBQLN1

Pathways & Interactionsfor UBQLN1

Drugs & Compoundsfor UBQLN1

Transcriptsfor UBQLN1

Expression for UBQLN1

Orthologsfor UBQLN1

Paralogsfor UBQLN1

SNPs/Variantsfor UBQLN1

Disorders & Mutationsfor UBQLN1

Medical Newsfor UBQLN1

Publicationsfor UBQLN1

Search for UBQLN1

Genome Databases showing UBQLN1

Other Databases showing UBQLN1

Specialized Databases showing UBQLN1

Licensable Technologiesfor UBQLN1

Servicesfor UBQLN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBQLN1

Summaries
for UBQLN1

Genomic Location
for UBQLN1

Proteins
for UBQLN1

Protein Domains/
Families
for UBQLN1

Gene Function
for UBQLN1

Pathways & Interactions
for UBQLN1

Drugs & Compounds
for UBQLN1

Transcripts
for UBQLN1

Expression
for UBQLN1

Orthologs
for UBQLN1

Paralogs
for UBQLN1

SNPs/Variants
for UBQLN1

Disorders & Mutations
for UBQLN1

Medical News
for UBQLN1

Publications
for UBQLN1

Licensable Technologies
for UBQLN1

Services
for UBQLN1