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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBP1 Gene

protein-coding   GIFtS: 51
GCID: GC03M033404

upstream binding protein 1 (LBP-1a)

 Explore 4 diseases affiliated with
UBP1 via our new
 Human Malady Compendium 
Biological research products
for UBP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Upstream Binding Protein 1 (LBP-1a)1 2     LBP1B2 5
LBP-1a1 2     LBP-1B2
Transcription Factor LBP-12 3     Upstream-Binding Protein 12
LBP1A2 5     LBP13

External Ids:    HGNC: 125071   Entrez Gene: 73422   Ensembl: ENSG000001535607   OMIM: 6097845   UniProtKB: Q9NZI73   

Export aliases for UBP1 gene to outside databases

Previous GC identifers: GC03M032735 GC03M033276 GC03M033401


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UBIP1_HUMAN, Q9NZI7
Function: Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental
expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the
alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in
regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site
and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box

Gene Wiki entry for UBP1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBP1 gene promoter:
         MEF-2A   TBP   AP-1   ATF-2   aMEF-2   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.3   Ensembl cytogenetic band:  3p22.3   HGNC cytogenetic band: 3p22.3

UBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBP1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M033404:  view genomic region     (about GC identifiers)

Start:
33,429,828 bp from pter      End:
33,482,863 bp from pter
Size:
53,036 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UBIP1_HUMAN, Q9NZI7 (See protein sequence)
Recommended Name: Upstream-binding protein 1  
Size: 540 amino acids; 60491 Da
Subunit: Interacts with TFCP2. Interacts with PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1
(By similarity)
Subcellular location: Nucleus
Secondary accessions: Q68CT0 Q86Y57 Q9H8V0 Q9UD76 Q9UD78
Alternative splicing: 2 isoforms:  Q9NZI7-1   Q9NZI7-4   

Explore the universe of human proteins at neXtProt for UBP1: NX_Q9NZI7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NZI7

  • UBP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001121632.1  NP_001121633.1  NP_055332.3  

    ENSEMBL proteins: 
     ENSP00000283629   ENSP00000395558   ENSP00000283628   ENSP00000393842   ENSP00000401614  

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    Uscn Proteins for UBP1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8114710


    UBP1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    UBP1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR007604 CP2
     IPR013761 SAM/pointed

    Graphical View of Domain Structure for InterPro Entry Q9NZI7

    ProtoNet protein and cluster: Q9NZI7

    1 Blocks protein family: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: UBIP1_HUMAN, Q9NZI7
    Similarity: Belongs to the grh/CP2 family. CP2 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: UBIP1_HUMAN, Q9NZI7
    Function: Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental
    expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the
    alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in
    regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site
    and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box
    Induction: By HIV-1 infection of lymphocytes

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    hsa-miR-193a-3p hsa-miR-449a hsa-miR-570 hsa-miR-508-3p hsa-miR-548m hsa-miR-3150b-3p hsa-miR-181b hsa-miR-193b
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8114710
    GO:0003714transcription corepressor activity TAS8114710


    UBP1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for UBP1:
     Increased G1 DNA content  Increased number of mitotic ce 

    Animal Models:
         Mouse knock-out Ubp1tm1Jmc for UBP1
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ubp1):
     cardiovascular system  embryogenesis  growth/size  mortality/aging  muscle 

    UBP1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/15 Interacting proteins for UBP1 (Q9NZI73 ENSP000002836284) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TFCP2L1Q9NZI63, ENSP000002637074I2D: score=2 STRING: ENSP00000263707
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    TFCP2Q128003, ENSP000002579154I2D: score=1 STRING: ENSP00000257915
    EWSR1Q018443I2D: score=1 
    GMEB1Q9Y6923I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8114710
    GO:0019079viral genome replication TAS8114710
    GO:0045892negative regulation of transcription, DNA-dependent TAS8114710


    UBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBP1
    Search CenterWatch for drugs/clinical trials and news about UBP1 / UBIP1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBP1 gene (3 alternative transcripts): 
    NM_001128160.1  NM_001128161.1  NM_014517.4  

    Unigene Cluster for UBP1:

    Upstream binding protein 1 (LBP-1a)
    Hs.729120  [show with all ESTs]
    Unigene Representative Sequence: CR749798
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283629(uc003cfq.4 uc003cfr.4 uc010hga.3) ENST00000492136
    ENST00000447368 ENST00000466441 ENST00000283628 ENST00000486388 ENST00000464787
    ENST00000411650 ENST00000490112 ENST00000467613 ENST00000481761 ENST00000456378
    ENST00000496310

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    hsa-miR-193a-3p hsa-miR-449a hsa-miR-570 hsa-miR-508-3p hsa-miR-548m hsa-miR-3150b-3p hsa-miR-181b hsa-miR-193b
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    Additional cDNA sequence: 

    AF198487.1 AK023274.1 AK023278.1 AK023322.1 AK027177.1 AK125415.1 AK293100.1 AK309430.1 
    AL133032.1 AL831847.1 BC047235.1 CR749798.1 

    11 DOTS entries:

    DT.316514  DT.100785110  DT.100785116  DT.91989255  DT.100785112  DT.92037481  DT.100785113  DT.91959715 
    DT.120858886  DT.100785114  DT.97803084 

    24/233 AceView cDNA sequences (see all 233):

    N24216 BE047279 AK125415 AI632968 AA322784 AW198184 BQ130929 BM460126 
    AA630956 H88232 H88344 AL133032 BI714831 AW469422 AI925511 AW015715 
    AA443722 AL831847 BE328428 CA337401 AU133899 AI753718 AA299061 CB152416 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for UBP1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                                                                                -                                                                           
    SP2:                                                                                -                                         -                                 
    SP3:                                                                                                                                                            
    SP4:                                -     -                                         -                                                                           
    SP5:              -     -     -     -     -     -     -                             -                                                                           

    ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b
    SP1:              -               
    SP2:              -               
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for UBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTCTGTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See UBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBP1

    SOURCE GeneReport for Unigene cluster: Hs.729120

    UniProtKB/Swiss-Prot: UBIP1_HUMAN, Q9NZI7
    Tissue specificity: Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep-G2 and HeLa cell lines

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UBP1 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves UBP11 upstream binding protein 1 (LBP-1a) 82.74(n)
    89.57(a)
      428458  XM_426018.3  XP_426018.3 
    lizard
    (Anolis carolinensis)
    Reptilia UBP16
    --
    82(a)
    1 ↔ 1
    GL343324.1(824088-879229)
    zebrafish
    (Danio rerio)
    Actinopterygii ubp11 upstream binding protein 1 (LBP-1a) 69.81(n)
    75.44(a)
      100136855  NM_001114574.1  NP_001108046.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gem3 regulation of transcription transcription
    factor
    43(a)   46F2   --


    ENSEMBL Gene Tree for UBP1 (if available)
    TreeFam Gene Tree for UBP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBP1 gene
    GRHL32  GRHL12  TFCP22  GRHL22  TFCP2L12  
    3 SIMAP similar genes for UBP1 using alignment to 3 protein entries:     UBIP1_HUMAN (see all proteins):
    DKFZp564C0164    TFCP2    TFCP2L1

    UBP1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UBP1
    PGOHUM00000259226


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/914 NCBI SNPs in UBP1 are shown (see all 914    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1128603331,2
    C,--33429359(+) ATCAAA/GACCAT 3 -- ds50010--------
    rs130653591,2
    C,F,--33429404(+) AAATAA/CAAAAA 3 -- ds50014Minor allele frequency- C:0.25NA WA 8
    rs46789481,2
    C,A,--33429526(+) CACTGC/TACTCC 3 -- ds50011Minor allele frequency- T:0.50NA 2
    rs348606411,2
    C--33429562(+) GTCTC-/AAAAAAA 3 -- ds50011Minor allele frequency- AA:0.00NA 2
    rs1809643461,2
    --33429606(+) TTAAAA/GTCTGG 3 -- ds50010--------
    rs776770471,2
    C--33429636(+) TAGTTA/TGTTAG 3 -- ds50010--------
    rs750349021,2
    C--33429649(+) AGTTAA/TTGGAA 3 -- ds50010--------
    rs1835868591,2
    --33429726(+) AACCTC/TTTACT 3 -- ds50010--------
    rs1498034711,2
    C,--33429809(+) TGGGA-/TTTTTA 3 -- ds50010--------
    rs1464846961,2
    C,--33429948(+) AACTC-/AACGTT 6 -- ut310--------

    HapMap Linkage Disequilibrium report for UBP1 (33429828 - 33482863 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for UBP1
         1 CNV: 3424
         1 Indel: 33733

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    UBP1 for disorders           About GeneDecksing

    OMIM gene information: 609784    OMIM disorders: --

    4 diseases for UBP1:    About MalaCards
    herpes simplex    immunodeficiency    cholesterol    hiv type 1

    1 Novoseek disease relationship for UBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 49.3 2 2006421 (1), 8114710 (1)


    Export disorders for UBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBP1 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with UBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro. (PubMed id 8114710)1, 2, 3, 9 Yoon J.-B.... Roeder R.G. (1994)
    2. Repression of HIV-1 transcription by a cellular protein. (PubMed id 2006421)1, 2, 9 Kato H.... Roeder R.G. (1991)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc. (PubMed id 10644752)1, 2 Huang N. and Miller W.L. (2000)
    6. LBP proteins modulate SF1-independent expression of P450scc in human placental JEG-3 cells. (PubMed id 15471945)1, 9 Huang N. and Miller W.L. (2005)
    7. A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro. (PubMed id 7836461)1, 9 Parada C.A....Roeder R.G. (1995)
    8. Transactivation activity of LBP-1 proteins and their dimerization in living cells. (PubMed id 19751393)1, 9 Katsura A....Sogawa K. (2009)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics. (PubMed id 21956701)1 Akimov V....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7342 HGNC: 12507 AceView: UBP1 Ensembl:ENSG00000153560 euGenes: HUgn7342
    ECgene: UBP1 H-InvDB: UBP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBP1 gene:
    Search GeneIP for patents involving UBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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