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Aliases for UBP1 Gene

Aliases for UBP1 Gene

  • Upstream Binding Protein 1 2 3
  • Transcription Factor LBP-1 3 4
  • Upstream Binding Protein 1 (LBP-1a) 5
  • Upstream-Binding Protein 1 3
  • LBP-1B 3
  • LBP-1a 3
  • LBP1A 3
  • LBP1B 3
  • LBP1 4

External Ids for UBP1 Gene

Previous GeneCards Identifiers for UBP1 Gene

  • GC03M032735
  • GC03M033276
  • GC03M033401

Summaries for UBP1 Gene

GeneCards Summary for UBP1 Gene

UBP1 (Upstream Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is TFCP2.

UniProtKB/Swiss-Prot for UBP1 Gene

  • Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.

Gene Wiki entry for UBP1 Gene

Additional gene information for UBP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBP1 Gene

Genomics for UBP1 Gene

Regulatory Elements for UBP1 Gene

Enhancers for UBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H033437 1.4 ENCODE dbSUPER 28.9 +1.4 1435 5 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CNOT10 PDCD6IP UBP1 FBXL2 GLB1 TMPPE CMTM6 PIR40256 GC03M033417
GH03H032832 1.1 ENCODE dbSUPER 31.7 +608.1 608077 0 ZFP64 ZNF140 ZNF266 ZNF384 ZNF697 ZNF664 ZNF791 POLR2A GLI2 ZNF547 CNOT10 UBP1 PDCD6IP FBXL2 TMPPE GLB1 TRIM71 PIR32571
GH03H033425 1.3 Ensembl ENCODE dbSUPER 19 +13.2 13239 5 KLF1 FEZF1 ZNF384 ZIC2 BCL11B ZFHX2 ZNF316 GLI2 ZBTB20 EGR2 FBXL2 UBP1 GC03M033417 PIR40256
GH03H033113 1.1 ENCODE 19.4 +326.7 326665 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS CNOT10 PDCD6IP UBP1 CRTAP TMPPE GLB1 ENSG00000271643 ENSG00000236732 ENSG00000271020 GC03P033114
GH03H032778 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +660.5 660541 4 HDGF FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 DEK CNOT10 TRIM71 SUGT1P2 CNOT10-AS1 UBP1 RPL23AP43
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBP1 on UCSC Golden Path with GeneCards custom track

Promoters for UBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000150644 1571 3601 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Genomic Location for UBP1 Gene

Chromosome:
3
Start:
33,388,336 bp from pter
End:
33,441,371 bp from pter
Size:
53,036 bases
Orientation:
Minus strand

Genomic View for UBP1 Gene

Genes around UBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBP1 Gene

Proteins for UBP1 Gene

  • Protein details for UBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZI7-UBIP1_HUMAN
    Recommended name:
    Upstream-binding protein 1
    Protein Accession:
    Q9NZI7
    Secondary Accessions:
    • Q68CT0
    • Q86Y57
    • Q9H8V0
    • Q9UD76
    • Q9UD78

    Protein attributes for UBP1 Gene

    Size:
    540 amino acids
    Molecular mass:
    60491 Da
    Quaternary structure:
    • Interacts with TFCP2. Interacts with PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity).

    Alternative splice isoforms for UBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBP1 Gene

Post-translational modifications for UBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBP1 Gene

No data available for DME Specific Peptides for UBP1 Gene

Domains & Families for UBP1 Gene

Gene Families for UBP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for UBP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZI7

UniProtKB/Swiss-Prot:

UBIP1_HUMAN :
  • Belongs to the grh/CP2 family. CP2 subfamily.
Family:
  • Belongs to the grh/CP2 family. CP2 subfamily.
genes like me logo Genes that share domains with UBP1: view

Function for UBP1 Gene

Molecular function for UBP1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
UniProtKB/Swiss-Prot Induction:
By HIV-1 infection of lymphocytes.

Gene Ontology (GO) - Molecular Function for UBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 8114710
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 8114710
GO:0003714 transcription corepressor activity TAS 8114710
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with UBP1: view
genes like me logo Genes that share phenotypes with UBP1: view

Animal Models for UBP1 Gene

MGI Knock Outs for UBP1:

Animal Model Products

CRISPR Products

miRNA for UBP1 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UBP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBP1 Gene

Localization for UBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBP1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8114710
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with UBP1: view

Pathways & Interactions for UBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8114710
GO:0019079 viral genome replication TAS 8114710
genes like me logo Genes that share ontologies with UBP1: view

No data available for Pathways by source and SIGNOR curated interactions for UBP1 Gene

Drugs & Compounds for UBP1 Gene

No Compound Related Data Available

Transcripts for UBP1 Gene

Unigene Clusters for UBP1 Gene

Upstream binding protein 1 (LBP-1a):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UBP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for UBP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2: - -
SP3:
SP4: - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8:

ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for UBP1 Gene

GeneLoc Exon Structure for
UBP1
ECgene alternative splicing isoforms for
UBP1

Expression for UBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBP1 Gene

Protein differential expression in normal tissues from HIPED for UBP1 Gene

This gene is overexpressed in Plasma (36.6) and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBP1 Gene



Protein tissue co-expression partners for UBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBP1 Gene:

UBP1

SOURCE GeneReport for Unigene cluster for UBP1 Gene:

Hs.729120

mRNA Expression by UniProt/SwissProt for UBP1 Gene:

Q9NZI7-UBIP1_HUMAN
Tissue specificity: Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep-G2 and HeLa cell lines.

Evidence on tissue expression from TISSUES for UBP1 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with UBP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBP1 Gene

Orthologs for UBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBP1 33 34
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia UBP1 33 34
  • 92.64 (n)
mouse
(Mus musculus)
Mammalia Ubp1 33 16 34
  • 91.05 (n)
rat
(Rattus norvegicus)
Mammalia Ubp1 33
  • 90.86 (n)
cow
(Bos Taurus)
Mammalia UBP1 33 34
  • 89.86 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 83 (a)
OneToMany
-- 34
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia UBP1 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBP1 33 34
  • 82.5 (n)
lizard
(Anolis carolinensis)
Reptilia UBP1 34
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ubp1 33 34
  • 68.77 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007065 33
  • 51.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta gem 35
  • 43 (a)
Species where no ortholog for UBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBP1 Gene

ENSEMBL:
Gene Tree for UBP1 (if available)
TreeFam:
Gene Tree for UBP1 (if available)

Paralogs for UBP1 Gene

Paralogs for UBP1 Gene

(3) SIMAP similar genes for UBP1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for UBP1 Gene

genes like me logo Genes that share paralogs with UBP1: view

Variants for UBP1 Gene

Sequence variations from dbSNP and Humsavar for UBP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000042094 -- 33,404,450(+) AATGA(A/G)GACTC intron-variant, nc-transcript-variant, downstream-variant-500B
rs1000099112 -- 33,431,348(+) TATAC(C/G/T)AATTC intron-variant
rs1000140679 -- 33,413,680(+) CCCAG(A/C)AGCCA intron-variant
rs1000257366 -- 33,413,991(+) AGTAA(C/G)AACCA intron-variant
rs1000368040 -- 33,393,987(+) CAATA(C/T)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBP1 Gene

Variant ID Type Subtype PubMed ID
esv2759138 CNV gain 17122850
nsv1001132 CNV gain 25217958
nsv10259 CNV loss 18304495

Variation tolerance for UBP1 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.28; 95.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBP1 Gene

Disorders for UBP1 Gene

Relevant External Links for UBP1

Genetic Association Database (GAD)
UBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBP1

No disorders were found for UBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBP1 Gene

Publications for UBP1 Gene

  1. Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro. (PMID: 8114710) Yoon JB … Roeder RG (Molecular and cellular biology 1994) 2 3 4 22 60
  2. Repression of HIV-1 transcription by a cellular protein. (PMID: 2006421) Kato H … Roeder RG (Science (New York, N.Y.) 1991) 3 4 22 60
  3. Transactivation activity of LBP-1 proteins and their dimerization in living cells. (PMID: 19751393) Katsura A … Sogawa K (Genes to cells : devoted to molecular & cellular mechanisms 2009) 3 22 60
  4. LBP proteins modulate SF1-independent expression of P450scc in human placental JEG-3 cells. (PMID: 15471945) Huang N … Miller WL (Molecular endocrinology (Baltimore, Md.) 2005) 3 22 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for UBP1 Gene

Sources for UBP1 Gene

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