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Aliases for UBP1 Gene

Aliases for UBP1 Gene

  • Upstream Binding Protein 1 (LBP-1a) 2 3
  • Transcription Factor LBP-1 3 4
  • LBP1A 3 6
  • LBP1B 3 6
  • Upstream-Binding Protein 1 3
  • LBP-1B 3
  • LBP-1a 3
  • LBP1 4

External Ids for UBP1 Gene

Summaries for UBP1 Gene

GeneCards Summary for UBP1 Gene

UBP1 (Upstream Binding Protein 1 (LBP-1a)) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is TFCP2L1.

UniProtKB/Swiss-Prot for UBP1 Gene

  • Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.

Gene Wiki entry for UBP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBP1 Gene

Genomics for UBP1 Gene

Genomic Location for UBP1 Gene

Start:
33,388,336 bp from pter
End:
33,441,371 bp from pter
Size:
53,036 bases
Orientation:
Minus strand

Genomic View for UBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBP1 Gene

Regulatory Elements for UBP1 Gene

Proteins for UBP1 Gene

  • Protein details for UBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZI7-UBIP1_HUMAN
    Recommended name:
    Upstream-binding protein 1
    Protein Accession:
    Q9NZI7
    Secondary Accessions:
    • Q68CT0
    • Q86Y57
    • Q9H8V0
    • Q9UD76
    • Q9UD78

    Protein attributes for UBP1 Gene

    Size:
    540 amino acids
    Molecular mass:
    60491 Da
    Quaternary structure:
    • Interacts with TFCP2. Interacts with PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity).

    Alternative splice isoforms for UBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBP1 Gene

Proteomics data for UBP1 Gene at MOPED

Post-translational modifications for UBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBP1 Gene

No data available for DME Specific Peptides for UBP1 Gene

Domains for UBP1 Gene

Protein Domains for UBP1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

UBIP1_HUMAN
Family:
  • Belongs to the grh/CP2 family. CP2 subfamily.:
    • Q9NZI7
genes like me logo Genes that share domains with UBP1: view

No data available for Gene Families for UBP1 Gene

Function for UBP1 Gene

Molecular function for UBP1 Gene

UniProtKB/Swiss-Prot Function: Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
UniProtKB/Swiss-Prot Induction: By HIV-1 infection of lymphocytes.

Gene Ontology (GO) - Molecular Function for UBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 8114710
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8114710
GO:0003714 transcription corepressor activity TAS 8114710
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with UBP1: view
genes like me logo Genes that share phenotypes with UBP1: view

Animal Models for UBP1 Gene

MGI Knock Outs for UBP1:

miRNA for UBP1 Gene

miRTarBase miRNAs that target UBP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for UBP1 Gene

Localization for UBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBP1 Gene COMPARTMENTS Subcellular localization image for UBP1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8114710
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with UBP1: view

Pathways for UBP1 Gene

SuperPathways for UBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8114710
GO:0019079 viral genome replication TAS 8114710
GO:0045892 negative regulation of transcription, DNA-templated TAS 8114710
genes like me logo Genes that share ontologies with UBP1: view

No data available for Pathways by source for UBP1 Gene

Transcripts for UBP1 Gene

Unigene Clusters for UBP1 Gene

Upstream binding protein 1 (LBP-1a):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2: - -
SP3:
SP4: - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8:

ExUns: 19 ^ 20 ^ 21 ^ 22a · 22b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for UBP1 Gene

GeneLoc Exon Structure for
UBP1
ECgene alternative splicing isoforms for
UBP1

Expression for UBP1 Gene

mRNA expression in normal human tissues for UBP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBP1 Gene

SOURCE GeneReport for Unigene cluster for UBP1 Gene Hs.729120

mRNA Expression by UniProt/SwissProt for UBP1 Gene

Q9NZI7-UBIP1_HUMAN
Tissue specificity: Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep-G2 and HeLa cell lines.
genes like me logo Genes that share expressions with UBP1: view

Orthologs for UBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBP1 36
  • 99.75 (n)
  • 99.44 (a)
UBP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBP1 36
  • 89.86 (n)
  • 93.66 (a)
UBP1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBP1 36
  • 92.64 (n)
  • 94.62 (a)
UBP1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubp1 36
  • 91.05 (n)
  • 94.07 (a)
Ubp1 16
Ubp1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 76 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia UBP1 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubp1 36
  • 90.86 (n)
  • 94.07 (a)
chicken
(Gallus gallus)
Aves UBP1 36
  • 82.5 (n)
  • 89.39 (a)
UBP1 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBP1 37
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ubp1 36
  • 68.77 (n)
  • 74.14 (a)
ubp1 37
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007065 36
  • 51.78 (n)
  • 49.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta gem 38
  • 43 (a)
Species with no ortholog for UBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBP1 Gene

ENSEMBL:
Gene Tree for UBP1 (if available)
TreeFam:
Gene Tree for UBP1 (if available)

Paralogs for UBP1 Gene

Paralogs for UBP1 Gene

Selected SIMAP similar genes for UBP1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for UBP1 Gene

genes like me logo Genes that share paralogs with UBP1: view

Variants for UBP1 Gene

Sequence variations from dbSNP and Humsavar for UBP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs530977 -- 33,419,689(+) TAAAG(G/T)GGTTT intron-variant
rs868318 -- 33,414,822(+) TGAAC(C/G)CTTTT intron-variant
rs884796 -- 33,415,135(+) TTTAA(C/G)CAGCT intron-variant
rs940230 -- 33,426,040(+) ATATA(G/T)CACTT intron-variant
rs940231 -- 33,426,052(+) AAAAA(A/C)TTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBP1 Gene

Variant ID Type Subtype PubMed ID
dgv1445e1 CNV Complex 17122850
nsv10259 CNV Loss 18304495

Relevant External Links for UBP1 Gene

HapMap Linkage Disequilibrium report
UBP1

Disorders for UBP1 Gene

(1) Novoseek inferred disease relationships for UBP1 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 49.3 2

Relevant External Links for UBP1

Genetic Association Database (GAD)
UBP1
genes like me logo Genes that share disorders with UBP1: view

No data available for UniProtKB/Swiss-Prot for UBP1 Gene

Publications for UBP1 Gene

  1. Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro. (PMID: 8114710) Yoon J.-B. … Roeder R.G. (Mol. Cell. Biol. 1994) 2 3 4 23
  2. Repression of HIV-1 transcription by a cellular protein. (PMID: 2006421) Kato H. … Roeder R.G. (Science 1991) 3 4 23
  3. A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro. (PMID: 7836461) Parada C.A. … Roeder R.G. (J. Biol. Chem. 1995) 3 23
  4. LBP proteins modulate SF1-independent expression of P450scc in human placental JEG-3 cells. (PMID: 15471945) Huang N. … Miller W.L. (Mol. Endocrinol. 2005) 3 23
  5. Transactivation activity of LBP-1 proteins and their dimerization in living cells. (PMID: 19751393) Katsura A. … Sogawa K. (Genes Cells 2009) 3 23

Products for UBP1 Gene

Sources for UBP1 Gene

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