UBOX5 Gene
protein-coding GIFtS: 54
GCID: GC20M003088
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|
U-box domain containing 5
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Aliases
for UBOX5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| U-Box Domain Containing 51 2 | | UBCE7IP52 3 | | RNF371 2 3 | | U-Box Domain-Containing Protein 52 3 | | UIP51 2 | | Ubce7ip51 | | KIAA08601 3 | | RING Finger Protein 372 | | Ubiquitin-Conjugating Enzyme 7-Interacting Protein 52 3 | | Ubiquitin Conjugating Enzyme 7 Interacting Protein 52 |
Export aliases for UBOX5 gene to outside databasesPrevious GC identifers: GC20M003039 GC20M003040 GC20M003041 GC20M003042 GC20M003043 GC20M003044 GC20M003045 GC20M003046 GC20M003047 GC20M003048 GC20M003049 |
Summaries
for UBOX5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBOX5:
This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a rolein the ubiquitination pathway. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Jun2012)
Gene Wiki entry for UBOX5
|
Genomic Views
for UBOX5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBOX5 gene promoter:
Pax-2 Pax-2a NF-kappaB GATA-2 MZF-1 Ik-2 CP2 c-Myb Zic3 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBOX5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBOX5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13UBOX5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M003088: view genomic region
(about GC identifiers)
Start:
|
3,088,219 bp from pter |
End:
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3,140,842 bp from pter |
Size:
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52,624 bases |
Orientation:
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minus strand |
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Proteins
for UBOX5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RNF37_HUMAN, O94941 (See
protein sequence)Recommended Name: RING finger protein 37 Size: 541 amino acids; 58966 Da
Subunit: Interacts with UBE2L3 (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA74883.2; Type=Erroneous initiation;
Secondary accessions: Q6IAR5 Q86X87 Q9H4J2Alternative splicing: 2 isoforms: O94941-1 O94941-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UBOX5: NX_O94941
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O94941
UBOX5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001254513.1 NP_055763.1 NP_955447.1
ENSEMBL proteins: ENSP00000217173 ENSP00000311726 ENSP00000404364 Reactome Protein details: O94941
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000151 | ubiquitin ligase complex |
IEA | -- | | GO:0005634 | nucleus |
IEA | -- |
UBOX5 for ontologies About GeneDecksing
UBOX5 Antibody Products:
Assay Products for UBOX5: |
Protein
Domains /
Families
for UBOX5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBOX5 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O94941ProtoNet protein and cluster: O94941 2 Blocks protein families: IPB001841 Zn-finger IPB003613 Zn-finger
UniProtKB/Swiss-Prot: RNF37_HUMAN, O94941Similarity: Contains 1 RING-type zinc fingerSimilarity: Contains 1 U-box domain |
Function
for UBOX5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBOX5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBOX5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for UBOX5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBOX5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBOX5 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
-- | -- | | GO:0008270 | zinc ion binding |
IEA | -- | | GO:0034450 | ubiquitin-ubiquitin ligase activity |
IEA | -- |
UBOX5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for UBOX5:
|
Pathways & Interactions
for UBOX5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for UBOX5
1 
Kegg Pathway (Kegg details for UBOX5):
UBOX5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBOX5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/22 Interacting proteins for UBOX5 (O949413 ENSP000002171734) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000209 | protein polyubiquitination |
IEA | -- |
UBOX5 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBOX5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBOX5
Search CenterWatch for drugs/clinical trials and news about UBOX5 / RNF37
|
Transcripts
for UBOX5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBOX5 gene (3 alternative transcripts): NM_001267584.1 NM_014948.3 NM_199415.2 Unigene Cluster for UBOX5: U-box domain containing 5 Hs.654646 [show with all ESTs]Unigene Representative Sequence: NM_0149483 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000217173(uc002whw.3 uc002why.1) ENST00000348031(uc002whx.3)
ENST00000449731
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBOX5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBOX5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): UBOX5 (NM_199415) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBOX5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBOX5 |
Additional cDNA sequence: AB020667.1 AK022444.1 AK222570.1 AK222876.1 BC000515.2 BC046122.1 BC064544.1 CR457089.1 6 DOTS entries: DT.213203 DT.100783984 DT.92427815 DT.100783983 DT.100703439 DT.86835779 24/218 AceView cDNA sequences (see all 218): BM551904 AW516198 AU129412 BQ065072 BE673075 BQ642543 BQ059039 BQ446617 BM672562 BC064544 BQ062115 BM808548 BX492152 BQ642172 BQ423809 CR593540 BQ059605 AI656235 CN484275 NM_199415 CD676820 BE252871 BM983023 AI768494
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for UBOX5 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | - | | | | | | - | | - | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UBOX5
|
Expression
for UBOX5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBOX5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACTCTTAG
About this image
See UBOX5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBOX5
SOURCE GeneReport for Unigene cluster: Hs.654646
SABiosciences Custom PCR Arrays for UBOX5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBOX5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBOX5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBOX5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBOX5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBOX5 |
Orthologs
for UBOX5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for UBOX5 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for UBOX5 (if available)
TreeFam Gene Tree for UBOX5 (if available) |
Paralogs
for UBOX5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for UBOX5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBOX5 (3088219 - 3140842 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for UBOX5
2 CNVs: 6047 5121 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBOX5 |
|
Disorders
/ Diseases
for UBOX5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBOX5 for disorders About GeneDecksing
2  diseases for UBOX5: About MalaCardsneurohypophyseal diabetes insipidus diabetes insipidus
1 disease from the University of Copenhagen DISEASES database for UBOX5:Neurohypophyseal diabetes insipidus Export disorders for UBOX5 gene to outside databases
|
Publications
for UBOX5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBOX5 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with UBOX5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes. (PubMed id 11274149)1, 3 Pringa E....Harbers K. (2001)
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
- Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ancient origin of animal U-box ubiquitin ligases. (PubMed id 20979629)1 Marin I. (2010)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
|
External Searches for UBOX5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBOX5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBOX5 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing UBOX5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBOX5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBOX5 gene:
Search GeneIP for patents involving UBOX5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBOX5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for UBOX5 | | OriGene Custom Protein Services for UBOX5 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBOX5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBOX5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBOX5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBOX5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBOX5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBOX5 |
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| |  |  |  |  | | | | |
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 | | | UBOX5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBOX5 |
|  |  |  | | | | ThermoFisher Antibodies for UBOX5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBOX5 |
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