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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBOX5 Gene

protein-coding   GIFtS: 54
GCID: GC20M003088

U-Box Domain Containing 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
U-Box Domain Containing 51 2     UIP52
Ubiquitin-Conjugating Enzyme 7-Interacting Protein 52 3     RING Finger Protein 372
RNF372 3     Ubiquitin Conjugating Enzyme 7 Interacting Protein 52
UBCE7IP52 3     KIAA08603
U-Box Domain-Containing Protein 52 3     

External Ids:    HGNC: 177771   Entrez Gene: 228882   Ensembl: ENSG000001850197   UniProtKB: O949413   

Export aliases for UBOX5 gene to outside databases

Previous GC identifers: GC20M003039 GC20M003040 GC20M003041 GC20M003042 GC20M003043 GC20M003044 GC20M003045 GC20M003046 GC20M003047 GC20M003048 GC20M003049


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBOX5 Gene:
This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a
role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. (provided by
RefSeq, Jun 2012)

GeneCards Summary for UBOX5 Gene: 
UBOX5 (U-box domain containing 5) is a protein-coding gene. Diseases associated with UBOX5 include neurohypophyseal diabetes insipidus, and diabetes insipidus, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include ubiquitin-ubiquitin ligase activity and zinc ion binding.

Gene Wiki entry for UBOX5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBOX5 gene promoter:
         Pax-2   Pax-2a   NF-kappaB   GATA-2   MZF-1   Ik-2   CP2   c-Myb   Zic3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBOX5 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBOX5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBOX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

UBOX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBOX5 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M003088:  view genomic region     (about GC identifiers)

Start:
3,088,219 bp from pter      End:
3,140,842 bp from pter
Size:
52,624 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNF37_HUMAN, O94941 (See protein sequence)
Recommended Name: RING finger protein 37  
Size: 541 amino acids; 58966 Da
Subunit: Interacts with UBE2L3 (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA74883.2; Type=Erroneous initiation;
Secondary accessions: Q6IAR5 Q86X87 Q9H4J2
Alternative splicing: 2 isoforms:  O94941-1   O94941-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBOX5: NX_O94941

Explore proteomics data for UBOX5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94941

  • UBOX5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBOX5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001254513.1  NP_055763.1  NP_955447.1  

    ENSEMBL proteins: 
     ENSP00000217173   ENSP00000311726   ENSP00000404364  
    Reactome Protein details: O94941
    Human Recombinant Protein Products for UBOX5: 
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    Novus Biologicals UBOX5 Protein
    Novus Biologicals UBOX5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBOX5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IEA--
    GO:0005634nucleus IEA--

    UBOX5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers
    UBOX: U-box domain containing

    4 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR003613 Ubox_domain
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry O94941

    ProtoNet protein and cluster: O94941

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003613 Zn-finger


    UniProtKB/Swiss-Prot: RNF37_HUMAN, O94941
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 U-box domain


    UBOX5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ----
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0034450ubiquitin-ubiquitin ligase activity IEA--
         
    UBOX5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UBOX5:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBOX5 
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    SwitchGear 3'UTR luciferase reporter plasmidUBOX5 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBOX5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for UBOX5
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for UBOX5):
        Ubiquitin mediated proteolysis


    UBOX5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBOX5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/22 Interacting proteins for UBOX5 (O949413 ENSP000002171734) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLH1P406923, ENSP000002317904I2D: score=4 STRING: ENSP00000231790
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2V1Q134043, ENSP000003403054I2D: score=2 STRING: ENSP00000340305
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IEA--
    GO:0016567protein ubiquitination ----

    UBOX5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBOX5 (RNF37)

    Search CenterWatch for drugs/clinical trials and news about UBOX5 / RNF37

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBOX5 gene (3 alternative transcripts): 
    NM_001267584.1  NM_014948.3  NM_199415.2  

    Unigene Cluster for UBOX5:

    U-box domain containing 5
    Hs.654646  [show with all ESTs]
    Unigene Representative Sequence: NM_014948
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217173(uc002whw.3 uc002why.1) ENST00000348031(uc002whx.3)
    ENST00000449731
    miRNA
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    hsa-miR-3128 hsa-miR-4291 hsa-miR-550a hsa-miR-185* hsa-miR-922 hsa-miR-504 hsa-miR-661 hsa-miR-135b
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBOX5

    Additional mRNA sequence: 

    AB020667.1 AK022444.1 AK222570.1 AK222876.1 BC000515.2 BC046122.1 BC064544.1 CR457089.1 

    4 DOTS entries:

    DT.213203  DT.100783984  DT.92427815  DT.100783983 

    24/218 AceView cDNA sequences (see all 218):

    BM980040 CR593540 BE252871 AI768494 BE044059 BQ062115 BC011856 BQ423809 
    BC046122 BE673075 BI490972 BQ059039 BM477285 AW516198 BQ063210 BU634150 
    BM551904 CN484275 AI862396 BG481288 AI343443 BE296416 AU129412 BM927457 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for UBOX5 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                    -     -     -     -     -                 -                     
    SP2:                    -     -     -     -     -                 -                     
    SP3:                    -     -     -     -     -                 -     -               
    SP4:                          -                                                         
    SP5:                                                                                    


    ECgene alternative splicing isoforms for UBOX5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBOX5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACTCTTAG
    UBOX5 Expression
    About this image


    See UBOX5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBOX5

    SOURCE GeneReport for Unigene cluster: Hs.654646
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBOX5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UBOX5 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubox51 , 5 U box domain containing 51, 5 83.61(n)1
    79.59(a)1
      2 (63.24 cM)5
    1406291  NM_001255993.11  NP_001242922.11 
     1305900025 
    chicken
    (Gallus gallus)
    Aves UBOX51 U-box domain containing 5 68.42(n)
    64.1(a)
      422940  XM_420878.3  XP_420878.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.102212 Xenopus laevis transcribed sequence with weak similarity more 75.15(n)    BU900717.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC4028291 uncharacterized LOC402829 48.5(n)
    43.33(a)
      402829  XM_001335405.3  XP_001335441.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG22181 CG2218 43.19(n)
    28.89(a)
      43611  NM_143533.2  NP_651790.1 


    ENSEMBL Gene Tree for UBOX5 (if available)
    TreeFam Gene Tree for UBOX5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in UBOX5 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0464034
    ----see VAR_0464032 L P mis40--------
    VAR_0464024
    ----see VAR_0464022 T M mis40--------

    HapMap Linkage Disequilibrium report for UBOX5 (3088219 - 3140842 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for UBOX5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv526273CNV Loss19592680
    dgv4518n71CNV Loss21882294
    nsv180149CNV Loss16902084
    nsv521437CNV Loss19592680
    nsv912605CNV Loss21882294
    nsv912606CNV Loss21882294
    nsv833897CNV Loss17160897
    nsv912604CNV Loss21882294
    nsv524482CNV Gain19592680
    nsv833898CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for UBOX5:    About MalaCards
    neurohypophyseal diabetes insipidus    diabetes insipidus

    1 disease from the University of Copenhagen DISEASES database for UBOX5:
    Neurohypophyseal diabetes insipidus

    UBOX5 for disorders           About GeneDecksing


    Export disorders for UBOX5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBOX5 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with UBOX5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    4. Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes. (PubMed id 11274149)1, 3 Pringa E....Harbers K. (2001)
    5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    6. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    7. Direct and indirect control of mitogen-activated prote in kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/R AF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....Urbe S. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Ancient origin of animal U-box ubiquitin ligases. (PubMed id 20979629)1 Marin I. (2010)
    10. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22888 HGNC: 17777 AceView: UBCE7IP5 Ensembl:ENSG00000185019 euGenes: HUgn22888
    ECgene: UBOX5 Kegg: 22888 H-InvDB: UBOX5

    (According to HUGE)
    About This Section
    HUGE: KIAA0860

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBOX5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBOX5 gene:
    Search GeneIP for patents involving UBOX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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