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UBOX5 Gene

protein-coding   GIFtS: 54
GCID: GC20M003088

U-Box Domain Containing 5

  See UBOX5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
U-Box Domain Containing 51 2     UIP52
Ubiquitin-Conjugating Enzyme 7-Interacting Protein 52 3     RING Finger Protein 372
RNF372 3     Ubiquitin Conjugating Enzyme 7 Interacting Protein 52
UBCE7IP52 3     KIAA08603
U-Box Domain-Containing Protein 52 3     

External Ids:    HGNC: 177771   Entrez Gene: 228882   Ensembl: ENSG000001850197   UniProtKB: O949413   

Export aliases for UBOX5 gene to outside databases

Previous GC identifers: GC20M003039 GC20M003040 GC20M003041 GC20M003042 GC20M003043 GC20M003044 GC20M003045 GC20M003046 GC20M003047 GC20M003048 GC20M003049


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBOX5 Gene:
This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a
role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. (provided by
RefSeq, Jun 2012)

GeneCards Summary for UBOX5 Gene:
UBOX5 (U-box domain containing 5) is a protein-coding gene. Diseases associated with UBOX5 include neurohypophyseal diabetes insipidus. GO annotations related to this gene include ubiquitin-ubiquitin ligase activity.

Gene Wiki entry for UBOX5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBOX5 gene promoter:
         Pax-2   Pax-2a   NF-kappaB   GATA-2   MZF-1   Ik-2   CP2   c-Myb   Zic3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBOX5 promoter sequence
   Search Chromatin IP Primers for UBOX5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBOX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

UBOX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBOX5 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M003088:  view genomic region     (about GC identifiers)

Start:
3,088,219 bp from pter      End:
3,140,842 bp from pter
Size:
52,624 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RNF37_HUMAN, O94941 (See protein sequence)
Recommended Name: RING finger protein 37  
Size: 541 amino acids; 58966 Da
Subunit: Interacts with UBE2L3 (By similarity)
Sequence caution: Sequence=BAA74883.2; Type=Erroneous initiation;
Secondary accessions: Q6IAR5 Q86X87 Q9H4J2
Alternative splicing: 2 isoforms:  O94941-1   O94941-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBOX5: NX_O94941

Explore proteomics data for UBOX5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UBOX5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001254513.1  NP_055763.1  NP_955447.1  

    ENSEMBL proteins: 
     ENSP00000217173   ENSP00000311726   ENSP00000404364  
    Reactome Protein details: O94941

    UBOX5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for UBOX5

     
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    antibodies-online proteins for UBOX5 (4 products) 

     
    antibodies-online peptides for UBOX5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers
    UBOX: U-box domain containing

    4 InterPro protein domains:
     IPR003613 Ubox_domain
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS

    Graphical View of Domain Structure for InterPro Entry O94941

    ProtoNet protein and cluster: O94941

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003613 Zn-finger


    UniProtKB/Swiss-Prot: RNF37_HUMAN, O94941
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 U-box domain


    Find genes that share domains with UBOX5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ----
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0034450ubiquitin-ubiquitin ligase activity IEA--
         
    Find genes that share ontologies with UBOX5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UBOX5:
     Increased cell death HMECs cel 

         1 MGI phenotypic allele for Ubox5 (no phenotypes)

    Find genes that share phenotypes with UBOX5           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for UBOX5

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBOX5:
    hsa-let-7a-5p (MIRT052547)

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    Selected qRT-PCR Assays for microRNAs that regulate UBOX5 (see all 15):
    hsa-miR-3128 hsa-miR-4291 hsa-miR-550a hsa-miR-185* hsa-miR-922 hsa-miR-504 hsa-miR-661 hsa-miR-135b
    SwitchGear 3'UTR luciferase reporter plasmidUBOX5 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNF37_HUMAN, O94941: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IEA--
    GO:0005634nucleus IEA--

    Find genes that share ontologies with UBOX5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBOX5 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35


    Find genes that share SuperPaths with UBOX5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for UBOX5
        Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for UBOX5):
        Ubiquitin mediated proteolysis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBOX5
    Interactions:

        Search GeneGlobe Interaction Network for UBOX5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBOX5 (O949413 ENSP000002171734) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLH1P406923, ENSP000002317904I2D: score=4 STRING: ENSP00000231790
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2V1Q134043, ENSP000003403054I2D: score=2 STRING: ENSP00000340305
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IEA--
    GO:0016567protein ubiquitination ----

    Find genes that share ontologies with UBOX5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBOX5 (RNF37)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBOX5 gene (3 alternative transcripts): 
    NM_001267584.1  NM_014948.3  NM_199415.2  

    Unigene Cluster for UBOX5:

    U-box domain containing 5
    Hs.654646  [show with all ESTs]
    Unigene Representative Sequence: NM_014948
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217173(uc002whw.3 uc002why.1) ENST00000348031(uc002whx.3)
    ENST00000449731
    miRNA
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    Block miRNA regulation of human, mouse, rat UBOX5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBOX5 (see all 15):
    hsa-miR-3128 hsa-miR-4291 hsa-miR-550a hsa-miR-185* hsa-miR-922 hsa-miR-504 hsa-miR-661 hsa-miR-135b
    SwitchGear 3'UTR luciferase reporter plasmidUBOX5 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat UBOX5
      QuantiFast Probe-based Assays in human, mouse, rat UBOX5

    Additional mRNA sequence: 

    AB020667.1 AK022444.1 AK222570.1 AK222876.1 BC000515.2 BC046122.1 BC064544.1 CR457089.1 

    4 DOTS entries:

    DT.213203  DT.100783984  DT.92427815  DT.100783983 

    Selected AceView cDNA sequences (see all 218):

    AI862396 BQ643186 BC011856 BQ423809 BM980040 BE252871 AA465631 CD676820 
    AI521183 CR593540 BM808548 BC046122 BU507619 BQ642543 BC000515 BE044059 
    BM927457 BQ019153 BE296416 NM_014948 BQ059039 BU634150 AU129412 AW134699 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBOX5 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                    -     -     -     -     -                 -                     
    SP2:                    -     -     -     -     -                 -                     
    SP3:                    -     -     -     -     -                 -     -               
    SP4:                          -                                                         
    SP5:                                                                                    


    ECgene alternative splicing isoforms for UBOX5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBOX5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACTCTTAG
    UBOX5 Expression
    About this image

    UBOX5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBOX5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654646
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UBOX5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubox51 , 5 U box domain containing 51, 5 83.61(n)1
    79.59(a)1
      2 (63.24 cM)5
    1406291  NM_001255994.11  NP_001242923.11 
     1305900025 
    chicken
    (Gallus gallus)
    Aves UBOX51 U-box domain containing 5 68.42(n)
    64.1(a)
      422940  XM_420878.4  XP_420878.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.102212 Xenopus laevis transcribed sequence with weak similarity more 75.15(n)    BU900717.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ubox51 U-box domain containing 5 49.23(n)
    43.96(a)
      402829  XM_001335405.4  XP_001335441.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG22181 CG2218 44.04(n)
    30.34(a)
      43611  NM_143533.2  NP_651790.1 


    ENSEMBL Gene Tree for UBOX5 (if available)
    TreeFam Gene Tree for UBOX5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for UBOX5    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342058801,2,4
    ----see VAR_0464032 mis40--------
    rs9994091,2,4
    ----see VAR_0464022 mis40--------

    HapMap Linkage Disequilibrium report for UBOX5 (3088219 - 3140842 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for UBOX5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526273CNV Loss19592680
    dgv4518n71CNV Loss21882294
    nsv180149CNV Loss16902084
    nsv521437CNV Loss19592680
    nsv912605CNV Loss21882294
    nsv912606CNV Loss21882294
    nsv833897CNV Loss17160897
    nsv912604CNV Loss21882294
    nsv524482CNV Gain19592680
    nsv833898CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for UBOX5:    
    About MalaCards
    neurohypophyseal diabetes insipidus

    1 disease from the University of Copenhagen DISEASES database for UBOX5:
    Neurohypophyseal diabetes insipidus

    Find genes that share disorders with UBOX5           About GenesLikeMe


    Export disorders for UBOX5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBOX5 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with UBOX5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    4. Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes. (PubMed id 11274149)1, 3 Pringa E....Harbers K. (J. Biol. Chem. 2001)
    5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    6. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    7. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....UrbAc S. (J. Biol. Chem. 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Ancient origin of animal U-box ubiquitin ligases. (PubMed id 20979629)1 MarA-n I. (BMC Evol. Biol. 2010)
    10. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (Mol. Syst. Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22888 HGNC: 17777 AceView: UBCE7IP5 Ensembl:ENSG00000185019 euGenes: HUgn22888
    ECgene: UBOX5 Kegg: 22888 H-InvDB: UBOX5

    (According to HUGE)
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    HUGE: KIAA0860

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UBOX5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBOX5 gene:
    Search GeneIP for patents involving UBOX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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