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Aliases for UBOX5 Gene

Aliases for UBOX5 Gene

  • U-Box Domain Containing 5 2 3 5
  • Ubiquitin-Conjugating Enzyme 7-Interacting Protein 5 3 4
  • U-Box Domain-Containing Protein 5 3 4
  • UbcM4-Interacting Protein 5 3 4
  • UBCE7IP5 3 4
  • RNF37 3 4
  • HUIP5 3 4
  • UIP5 3 4
  • Ubiquitin Conjugating Enzyme 7 Interacting Protein 5 3
  • RING Finger Protein 37 3
  • EC 6.3.2.- 4
  • KIAA0860 4

External Ids for UBOX5 Gene

Previous GeneCards Identifiers for UBOX5 Gene

  • GC20M003039
  • GC20M003040
  • GC20M003041
  • GC20M003042
  • GC20M003043
  • GC20M003044
  • GC20M003045
  • GC20M003046
  • GC20M003047
  • GC20M003048
  • GC20M003049

Summaries for UBOX5 Gene

Entrez Gene Summary for UBOX5 Gene

  • This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for UBOX5 Gene

UBOX5 (U-Box Domain Containing 5) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for UBOX5 Gene

  • May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.

Gene Wiki entry for UBOX5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBOX5 Gene

Genomics for UBOX5 Gene

Regulatory Elements for UBOX5 Gene

Enhancers for UBOX5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around UBOX5 on UCSC Golden Path with GeneCards custom track

Promoters for UBOX5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for UBOX5 Gene

Chromosome:
20
Start:
3,107,573 bp from pter
End:
3,160,196 bp from pter
Size:
52,624 bases
Orientation:
Minus strand

Genomic View for UBOX5 Gene

Genes around UBOX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBOX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBOX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBOX5 Gene

Proteins for UBOX5 Gene

  • Protein details for UBOX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94941-RNF37_HUMAN
    Recommended name:
    RING finger protein 37
    Protein Accession:
    O94941
    Secondary Accessions:
    • Q6IAR5
    • Q86X87
    • Q9H4J2

    Protein attributes for UBOX5 Gene

    Size:
    541 amino acids
    Molecular mass:
    58966 Da
    Quaternary structure:
    • Interacts with UBE2L3. Interacts with VCP.
    SequenceCaution:
    • Sequence=BAA74883.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UBOX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBOX5 Gene

Post-translational modifications for UBOX5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBOX5 Gene

No data available for DME Specific Peptides for UBOX5 Gene

Domains & Families for UBOX5 Gene

Gene Families for UBOX5 Gene

Protein Domains for UBOX5 Gene

Graphical View of Domain Structure for InterPro Entry

O94941

UniProtKB/Swiss-Prot:

RNF37_HUMAN :
  • The U-box domain mediates interaction with E2 ubiquitin ligases and is required for the ubiquitin-protein ligase activity.
  • Contains 1 RING-type zinc finger.
Domain:
  • The U-box domain mediates interaction with E2 ubiquitin ligases and is required for the ubiquitin-protein ligase activity.
  • Contains 1 U-box domain.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with UBOX5: view

Function for UBOX5 Gene

Molecular function for UBOX5 Gene

UniProtKB/Swiss-Prot Function:
May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.

Enzyme Numbers (IUBMB) for UBOX5 Gene

Gene Ontology (GO) - Molecular Function for UBOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 11274149
GO:0034450 ubiquitin-ubiquitin ligase activity ISS --
genes like me logo Genes that share ontologies with UBOX5: view
genes like me logo Genes that share phenotypes with UBOX5: view

Animal Models for UBOX5 Gene

MGI Knock Outs for UBOX5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBOX5 Gene

Localization for UBOX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBOX5 Gene

Nucleus. Note=Enriched in nuclear bodies. {ECO:0000269 PubMed:11274149}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBOX5 Gene COMPARTMENTS Subcellular localization image for UBOX5 gene
Compartment Confidence
nucleus 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UBOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0016604 nuclear body IDA 11274149
genes like me logo Genes that share ontologies with UBOX5: view

Pathways & Interactions for UBOX5 Gene

genes like me logo Genes that share pathways with UBOX5: view

UniProtKB/Swiss-Prot O94941-RNF37_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBOX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination ISS --
genes like me logo Genes that share ontologies with UBOX5: view

No data available for SIGNOR curated interactions for UBOX5 Gene

Drugs & Compounds for UBOX5 Gene

No Compound Related Data Available

Transcripts for UBOX5 Gene

Unigene Clusters for UBOX5 Gene

U-box domain containing 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBOX5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: -
SP5:
SP6: - -
SP7:

Relevant External Links for UBOX5 Gene

GeneLoc Exon Structure for
UBOX5
ECgene alternative splicing isoforms for
UBOX5

Expression for UBOX5 Gene

mRNA expression in normal human tissues for UBOX5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBOX5 Gene



Protein tissue co-expression partners for UBOX5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBOX5 Gene:

UBOX5

SOURCE GeneReport for Unigene cluster for UBOX5 Gene:

Hs.654646

mRNA Expression by UniProt/SwissProt for UBOX5 Gene:

O94941-RNF37_HUMAN
Tissue specificity: Expressed in liver, heart, brain, kidney and testis.
genes like me logo Genes that share expression patterns with UBOX5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for UBOX5 Gene

Orthologs for UBOX5 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBOX5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBOX5 34
  • 88.87 (n)
  • 88.21 (a)
UBOX5 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubox5 34
  • 83.61 (n)
  • 79.59 (a)
Ubox5 16
Ubox5 35
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBOX5 34
  • 99.38 (n)
  • 99.45 (a)
UBOX5 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubox5 34
  • 82.96 (n)
  • 79.55 (a)
dog
(Canis familiaris)
Mammalia UBOX5 35
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBOX5 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBOX5 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBOX5 34
  • 68.42 (n)
  • 64.1 (a)
UBOX5 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9098 34
ubox5 34
  • 61.02 (n)
  • 57.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10221 34
zebrafish
(Danio rerio)
Actinopterygii ubox5 34
  • 49.23 (n)
  • 43.96 (a)
ubox5 35
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2218 34
  • 44.04 (n)
  • 30.34 (a)
CG2218 35
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToOne
Species where no ortholog for UBOX5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBOX5 Gene

ENSEMBL:
Gene Tree for UBOX5 (if available)
TreeFam:
Gene Tree for UBOX5 (if available)

Paralogs for UBOX5 Gene

No data available for Paralogs for UBOX5 Gene

Variants for UBOX5 Gene

Sequence variations from dbSNP and Humsavar for UBOX5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_046402 -
VAR_046403 -

Structural Variations from Database of Genomic Variants (DGV) for UBOX5 Gene

Variant ID Type Subtype PubMed ID
esv3645031 CNV loss 21293372
nsv1127811 CNV deletion 24896259
nsv1136497 CNV deletion 24896259
nsv180149 CNV deletion 16902084
nsv521437 CNV loss 19592680
nsv524482 CNV gain 19592680
nsv526273 CNV loss 19592680
nsv585276 CNV gain 21841781
nsv833897 CNV loss 17160897
nsv833898 CNV gain+loss 17160897

Variation tolerance for UBOX5 Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 50.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBOX5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBOX5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBOX5 Gene

Disorders for UBOX5 Gene

Relevant External Links for UBOX5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBOX5

No disorders were found for UBOX5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBOX5 Gene

Publications for UBOX5 Gene

  1. Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes. (PMID: 11274149) Pringa E. … Harbers K. (J. Biol. Chem. 2001) 2 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. U box proteins as a new family of ubiquitin-protein ligases. (PMID: 11435423) Hatakeyama S. … Nakayama K.I. (J. Biol. Chem. 2001) 3 4 65
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 65

Products for UBOX5 Gene

Sources for UBOX5 Gene

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