Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBN2 Gene

Aliases for UBN2 Gene

  • Ubinuclein 2 2 3
  • Ubinuclein-2 3
  • KIAA2030 4

External Ids for UBN2 Gene

Summaries for UBN2 Gene

GeneCards Summary for UBN2 Gene

UBN2 (Ubinuclein 2) is a Protein Coding gene. An important paralog of this gene is UBN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBN2 Gene

Genomics for UBN2 Gene

Genomic Location for UBN2 Gene

Start:
139,230,356 bp from pter
End:
139,308,236 bp from pter
Size:
77,881 bases
Orientation:
Plus strand

Genomic View for UBN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBN2 Gene

Regulatory Elements for UBN2 Gene

Proteins for UBN2 Gene

  • Protein details for UBN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZU65-UBN2_HUMAN
    Recommended name:
    Ubinuclein-2
    Protein Accession:
    Q6ZU65
    Secondary Accessions:
    • A4D1S2
    • Q2YDY4
    • Q6P1K0
    • Q86XN9
    • Q8N7D1

    Protein attributes for UBN2 Gene

    Size:
    1347 amino acids
    Molecular mass:
    146089 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05362.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL24038.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UBN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBN2 Gene

Proteomics data for UBN2 Gene at MOPED

Post-translational modifications for UBN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBN2 Gene

Domains for UBN2 Gene

Protein Domains for UBN2 Gene

Suggested Antigen Peptide Sequences for UBN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZU65

UniProtKB/Swiss-Prot:

UBN2_HUMAN
Family:
  • Belongs to the ubinuclein family.:
    • Q6ZU65
genes like me logo Genes that share domains with UBN2: view

No data available for Gene Families for UBN2 Gene

Function for UBN2 Gene

Gene Ontology (GO) - Molecular Function for UBN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
genes like me logo Genes that share ontologies with UBN2: view

Phenotypes for UBN2 Gene

GenomeRNAi human phenotypes for UBN2:
genes like me logo Genes that share phenotypes with UBN2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBN2 Gene

Localization for UBN2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBN2 Gene COMPARTMENTS Subcellular localization image for UBN2 gene
Compartment Confidence
golgi apparatus 4
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for UBN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with UBN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBN2 Gene

Pathways for UBN2 Gene

SuperPathways for UBN2 Gene

No Data Available

Interacting Proteins for UBN2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000418648%0d%0a9606.ENSP00000405965%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000418648 Q6ZU65-UBN2_HUMAN for UBN2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for UBN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with UBN2: view

No data available for Pathways by source for UBN2 Gene

Transcripts for UBN2 Gene

Unigene Clusters for UBN2 Gene

Ubinuclein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBN2 Gene

No ASD Table

Relevant External Links for UBN2 Gene

GeneLoc Exon Structure for
UBN2
ECgene alternative splicing isoforms for
UBN2

Expression for UBN2 Gene

mRNA expression in normal human tissues for UBN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for UBN2 Gene

SOURCE GeneReport for Unigene cluster for UBN2 Gene Hs.153458

mRNA Expression by UniProt/SwissProt for UBN2 Gene

Q6ZU65-UBN2_HUMAN
Tissue specificity: Expressed in several cell lines tested, including primary and transformed cell lines.
genes like me logo Genes that share expressions with UBN2: view

No data available for mRNA differential expression in normal tissues for UBN2 Gene

Orthologs for UBN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBN2 35
  • 99.75 (n)
  • 99.7 (a)
UBN2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBN2 35
  • 92.63 (n)
  • 93.38 (a)
UBN2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBN2 35
  • 93.16 (n)
  • 93.66 (a)
UBN2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubn2 35
  • 89.95 (n)
  • 91.78 (a)
Ubn2 16
Ubn2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia UBN2 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubn2 35
  • 89.57 (n)
  • 91.13 (a)
chicken
(Gallus gallus)
Aves UBN2 35
  • 77.43 (n)
  • 76.76 (a)
UBN2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBN2 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15765 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3197 35
ubn2 35
  • 63.52 (n)
  • 63.1 (a)
zebrafish
(Danio rerio)
Actinopterygii ubn2 35
  • 57.24 (n)
  • 55.88 (a)
ubn2 36
  • 36 (a)
OneToMany
UBN2 (1 of 2) 36
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta yemalpha 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for UBN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBN2 Gene

ENSEMBL:
Gene Tree for UBN2 (if available)
TreeFam:
Gene Tree for UBN2 (if available)

Paralogs for UBN2 Gene

Paralogs for UBN2 Gene

Selected SIMAP similar genes for UBN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UBN2: view

Variants for UBN2 Gene

Sequence variations from dbSNP and Humsavar for UBN2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1061574 -- 139,305,058(-) ATTCC(A/C/G)TGATA utr-variant-3-prime, intron-variant
rs2278061 -- 139,260,731(+) TAAAT(C/G)TTCAT intron-variant
rs2278062 -- 139,260,983(+) ATTTA(C/G)AAAAG intron-variant
rs2288071 -- 139,258,905(+) TAATA(A/T)TAATA intron-variant
rs2355149 -- 139,244,347(+) ATTAC(A/G)TTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBN2 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV Deletion 23290073
dgv2141e1 CNV Complex 17122850
esv2206384 CNV Deletion 18987734

Relevant External Links for UBN2 Gene

HapMap Linkage Disequilibrium report
UBN2
Human Gene Mutation Database (HGMD)
UBN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBN2 Gene

Disorders for UBN2 Gene

No disorders were found for UBN2 Gene.

No data available for UniProtKB/Swiss-Prot for UBN2 Gene

Publications for UBN2 Gene

  1. Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. (PMID: 19029251) Banumathy G. … Adams P.D. (Mol. Cell. Biol. 2009) 2 3 4
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for UBN2 Gene

Sources for UBN2 Gene

Back to Top

Content