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Aliases for UBN2 Gene

Aliases for UBN2 Gene

  • Ubinuclein 2 2 3
  • KIAA2030 4

External Ids for UBN2 Gene

Previous GeneCards Identifiers for UBN2 Gene

  • GC07P138568
  • GC07P138912
  • GC07P133226

Summaries for UBN2 Gene

GeneCards Summary for UBN2 Gene

UBN2 (Ubinuclein 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is UBN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBN2 Gene

Genomics for UBN2 Gene

Regulatory Elements for UBN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBN2 Gene

Chromosome:
7
Start:
139,229,565 bp from pter
End:
139,329,421 bp from pter
Size:
99,857 bases
Orientation:
Plus strand

Genomic View for UBN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBN2 Gene

Proteins for UBN2 Gene

  • Protein details for UBN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZU65-UBN2_HUMAN
    Recommended name:
    Ubinuclein-2
    Protein Accession:
    Q6ZU65
    Secondary Accessions:
    • A4D1S2
    • Q2YDY4
    • Q6P1K0
    • Q86XN9
    • Q8N7D1

    Protein attributes for UBN2 Gene

    Size:
    1347 amino acids
    Molecular mass:
    146089 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05362.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL24038.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UBN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBN2 Gene

Proteomics data for UBN2 Gene at MOPED

Post-translational modifications for UBN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBN2 Gene

Domains & Families for UBN2 Gene

Protein Domains for UBN2 Gene

Suggested Antigen Peptide Sequences for UBN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZU65

UniProtKB/Swiss-Prot:

UBN2_HUMAN :
  • Belongs to the ubinuclein family.
Family:
  • Belongs to the ubinuclein family.
genes like me logo Genes that share domains with UBN2: view

No data available for Gene Families for UBN2 Gene

Function for UBN2 Gene

Gene Ontology (GO) - Molecular Function for UBN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with UBN2: view

Phenotypes for UBN2 Gene

GenomeRNAi human phenotypes for UBN2:
genes like me logo Genes that share phenotypes with UBN2: view

Animal Model Products

miRNA for UBN2 Gene

miRTarBase miRNAs that target UBN2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBN2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for UBN2 Gene

Localization for UBN2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBN2 Gene COMPARTMENTS Subcellular localization image for UBN2 gene
Compartment Confidence
extracellular 5
nucleus 4
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for UBN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with UBN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBN2 Gene

Pathways & Interactions for UBN2 Gene

SuperPathways for UBN2 Gene

No Data Available

Interacting Proteins for UBN2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000418648%0d%0a9606.ENSP00000405965%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q6ZU65-UBN2_HUMAN ENSP00000418648 for UBN2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for UBN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with UBN2: view

No data available for Pathways by source and SIGNOR curated interactions for UBN2 Gene

Drugs & Compounds for UBN2 Gene

No Compound Related Data Available

Transcripts for UBN2 Gene

Unigene Clusters for UBN2 Gene

Ubinuclein 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBN2 Gene

No ASD Table

Relevant External Links for UBN2 Gene

GeneLoc Exon Structure for
UBN2
ECgene alternative splicing isoforms for
UBN2

Expression for UBN2 Gene

mRNA expression in normal human tissues for UBN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBN2 Gene

This gene is overexpressed in Heart (35.4), Serum (17.2), and Esophagus (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for UBN2 Gene



SOURCE GeneReport for Unigene cluster for UBN2 Gene Hs.153458

mRNA Expression by UniProt/SwissProt for UBN2 Gene

Q6ZU65-UBN2_HUMAN
Tissue specificity: Expressed in several cell lines tested, including primary and transformed cell lines.
genes like me logo Genes that share expression patterns with UBN2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for UBN2 Gene

Orthologs for UBN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBN2 35
  • 92.63 (n)
  • 93.38 (a)
UBN2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBN2 35
  • 93.16 (n)
  • 93.66 (a)
UBN2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubn2 35
  • 89.95 (n)
  • 91.78 (a)
Ubn2 16
Ubn2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBN2 35
  • 99.75 (n)
  • 99.7 (a)
UBN2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubn2 35
  • 89.57 (n)
  • 91.13 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia UBN2 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBN2 35
  • 77.43 (n)
  • 76.76 (a)
UBN2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBN2 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3197 35
ubn2 35
  • 63.52 (n)
  • 63.1 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15765 35
zebrafish
(Danio rerio)
Actinopterygii ubn2 35
  • 57.24 (n)
  • 55.88 (a)
ubn2 36
  • 36 (a)
OneToMany
UBN2 (1 of 2) 36
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta yemalpha 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for UBN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBN2 Gene

ENSEMBL:
Gene Tree for UBN2 (if available)
TreeFam:
Gene Tree for UBN2 (if available)

Paralogs for UBN2 Gene

Paralogs for UBN2 Gene

(1) SIMAP similar genes for UBN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UBN2: view

Variants for UBN2 Gene

Sequence variations from dbSNP and Humsavar for UBN2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1061574 -- 139,305,058(-) ATTCC(A/C/G)TGATA utr-variant-3-prime, intron-variant
rs2278061 -- 139,260,731(+) TAAAT(C/G)TTCAT intron-variant
rs2278062 -- 139,260,983(+) ATTTA(C/G)AAAAG intron-variant
rs2288071 -- 139,258,905(+) TAATA(A/T)TAATA intron-variant
rs2355149 -- 139,244,347(+) ATTAC(A/G)TTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBN2 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV Deletion 23290073
dgv2141e1 CNV Complex 17122850
esv2206384 CNV Deletion 18987734

Variation tolerance for UBN2 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBN2 Gene

HapMap Linkage Disequilibrium report
UBN2
Human Gene Mutation Database (HGMD)
UBN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBN2 Gene

Disorders for UBN2 Gene

Relevant External Links for UBN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBN2
genes like me logo Genes that share disorders with UBN2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBN2 Gene

Publications for UBN2 Gene

  1. Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. (PMID: 19029251) Banumathy G. … Adams P.D. (Mol. Cell. Biol. 2009) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naA^ve to therapy. (PMID: 23580065) Pieragostino D. … Del Boccio P. (Mol Biosyst 2013) 67
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67

Products for UBN2 Gene

Sources for UBN2 Gene

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