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Aliases for UBN2 Gene

Aliases for UBN2 Gene

  • Ubinuclein 2 2 3 5
  • Ubinuclein-2 3
  • KIAA2030 4

External Ids for UBN2 Gene

Previous GeneCards Identifiers for UBN2 Gene

  • GC07P138568
  • GC07P138912
  • GC07P133226

Summaries for UBN2 Gene

GeneCards Summary for UBN2 Gene

UBN2 (Ubinuclein 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is UBN1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBN2 Gene

Genomics for UBN2 Gene

Regulatory Elements for UBN2 Gene

Enhancers for UBN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G139297 0.9 ENCODE 11.4 +69.3 69268 3.2 ELF3 FOXA2 ARID4B SIN3A DNMT3B ZNF2 ZNF335 SCRT2 FOS CREM UBN2 RPL37AP5 GC07M139292 GC07M139316 RNU6-206P
GH07G139084 0.9 ENCODE dbSUPER 10.2 -143.9 -143922 1.4 GATAD2A SOX5 SOX13 TEAD1 HLF CEBPB HMG20A CEBPG TBX21 ZNF644 ZC3HAV1L RPL37AP5 UBN2 ZC3HAV1 RPL17P28
GH07G139183 0.8 ENCODE 11.3 -45.3 -45347 0.4 PKNOX1 CBX3 ATF1 TBL1XR1 TCF12 CREM CEBPB MBD2 CREB3 SMARCA4 RPL37AP5 UBN2 LOC100499191 FCF1P11
GH07G139302 0.7 ENCODE 11.4 +73.5 73466 0.9 BCOR ZNF146 CBX3 ZMYM3 GABPA NFIC JUND CBX5 HDAC2 HNF4G UBN2 RPL37AP5 GC07M139292 GC07M139316 RNU6-206P
GH07G139182 0.7 ENCODE 11.3 -47.2 -47161 2.4 CTCF TAL1 RAD21 FOSL1 TCF12 NCOR1 FOS TRIM24 SMARCE1 ELF1 UBN2 RPL37AP5 TTC26 ZC3HAV1 LOC100499191 FCF1P11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBN2 Gene

Chromosome:
7
Start:
139,229,565 bp from pter
End:
139,329,421 bp from pter
Size:
99,857 bases
Orientation:
Plus strand

Genomic View for UBN2 Gene

Genes around UBN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBN2 Gene

Proteins for UBN2 Gene

  • Protein details for UBN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZU65-UBN2_HUMAN
    Recommended name:
    Ubinuclein-2
    Protein Accession:
    Q6ZU65
    Secondary Accessions:
    • A4D1S2
    • Q2YDY4
    • Q6P1K0
    • Q86XN9
    • Q8N7D1

    Protein attributes for UBN2 Gene

    Size:
    1347 amino acids
    Molecular mass:
    146089 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05362.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL24038.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for UBN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBN2 Gene

Post-translational modifications for UBN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBN2 Gene

No data available for DME Specific Peptides for UBN2 Gene

Domains & Families for UBN2 Gene

Protein Domains for UBN2 Gene

Suggested Antigen Peptide Sequences for UBN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZU65

UniProtKB/Swiss-Prot:

UBN2_HUMAN :
  • Belongs to the ubinuclein family.
Family:
  • Belongs to the ubinuclein family.
genes like me logo Genes that share domains with UBN2: view

No data available for Gene Families for UBN2 Gene

Function for UBN2 Gene

Phenotypes for UBN2 Gene

genes like me logo Genes that share phenotypes with UBN2: view

Animal Model Products

miRNA for UBN2 Gene

miRTarBase miRNAs that target UBN2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBN2 Gene

Localization for UBN2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBN2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for UBN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with UBN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBN2 Gene

Pathways & Interactions for UBN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBN2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBN2 Gene

Drugs & Compounds for UBN2 Gene

No Compound Related Data Available

Transcripts for UBN2 Gene

Unigene Clusters for UBN2 Gene

Ubinuclein 2:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBN2 Gene

No ASD Table

Relevant External Links for UBN2 Gene

GeneLoc Exon Structure for
UBN2
ECgene alternative splicing isoforms for
UBN2

Expression for UBN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBN2 Gene

This gene is overexpressed in Heart (35.4), Serum (17.2), and Esophagus (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBN2 Gene



NURSA nuclear receptor signaling pathways regulating expression of UBN2 Gene:

UBN2

SOURCE GeneReport for Unigene cluster for UBN2 Gene:

Hs.153458

mRNA Expression by UniProt/SwissProt for UBN2 Gene:

Q6ZU65-UBN2_HUMAN
Tissue specificity: Expressed in several cell lines tested, including primary and transformed cell lines.

Evidence on tissue expression from TISSUES for UBN2 Gene

  • Nervous system(4.3)
  • Liver(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with UBN2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBN2 Gene

Orthologs for UBN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBN2 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia UBN2 34 35
  • 93.16 (n)
cow
(Bos Taurus)
Mammalia UBN2 34 35
  • 92.63 (n)
mouse
(Mus musculus)
Mammalia Ubn2 34 16 35
  • 89.95 (n)
rat
(Rattus norvegicus)
Mammalia Ubn2 34
  • 89.57 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 85 (a)
OneToMany
-- 35
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia UBN2 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBN2 34 35
  • 77.43 (n)
lizard
(Anolis carolinensis)
Reptilia UBN2 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubn2 34
  • 63.52 (n)
Str.3197 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15765 34
zebrafish
(Danio rerio)
Actinopterygii ubn2 34 35
  • 57.24 (n)
UBN2 (1 of 2) 35
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta yemalpha 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToMany
Species where no ortholog for UBN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBN2 Gene

ENSEMBL:
Gene Tree for UBN2 (if available)
TreeFam:
Gene Tree for UBN2 (if available)

Paralogs for UBN2 Gene

Paralogs for UBN2 Gene

(1) SIMAP similar genes for UBN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UBN2: view

Variants for UBN2 Gene

Sequence variations from dbSNP and Humsavar for UBN2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000069066 -- 139,246,232(+) TGGTA(A/G)TGCGC intron-variant
rs1000084221 -- 139,326,644(+) AAAAT(A/C)TTTGC intron-variant
rs1000099104 -- 139,298,427(+) CCCTC(A/C)ATCAG intron-variant, utr-variant-3-prime
rs1000115882 -- 139,315,906(+) ACCCC(A/G)TCTCT intron-variant
rs1000132512 -- 139,281,354(+) ACAAA(A/G)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBN2 Gene

Variant ID Type Subtype PubMed ID
esv2206384 CNV deletion 18987734
esv2735212 CNV deletion 23290073
esv2759567 CNV gain 17122850
nsv477777 CNV novel sequence insertion 20440878

Variation tolerance for UBN2 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBN2 Gene

Human Gene Mutation Database (HGMD)
UBN2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBN2 Gene

Disorders for UBN2 Gene

Relevant External Links for UBN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBN2

No disorders were found for UBN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBN2 Gene

Publications for UBN2 Gene

  1. Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. (PMID: 19029251) Banumathy G. … Adams P.D. (Mol. Cell. Biol. 2009) 2 3 4 64
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for UBN2 Gene

Sources for UBN2 Gene

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