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UBN1 Gene

protein-coding   GIFtS: 56
GCID: GC16P004897

Ubinuclein 1

  Search for UBN1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubinuclein 11 2     VT42
Ubiquitously Expressed Nuclear Protein2 3     ubinuclein-12
HIRA-Binding Protein2 3     Protein VT43
VT2     

External Ids:    HGNC: 125061   Entrez Gene: 298552   Ensembl: ENSG000001189007   OMIM: 6097715   UniProtKB: Q9NPG33   

Export aliases for UBN1 gene to outside databases

Previous GC identifers: GC16P004921 GC16P004898 GC16P004838


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UBN1 Gene:
UBN1 (ubinuclein 1) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is UBN2.

UniProtKB/Swiss-Prot: UBN1_HUMAN, Q9NPG3
Function: Acts as a novel regulator of senescence. Involved in the formation of senescence-associated
heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to
proliferation-promoting genes. May be required for replication-independent chromatin assembly




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBN1 gene promoter:
         AREB6   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBN1 promoter sequence
   Search Chromatin IP Primers for UBN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

UBN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBN1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P004897:  view genomic region     (about GC identifiers)

Start:
4,896,666 bp from pter      End:
4,932,363 bp from pter
Size:
35,698 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBN1_HUMAN, Q9NPG3 (See protein sequence)
Recommended Name: Ubinuclein-1  
Size: 1134 amino acids; 121520 Da
Subunit: Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with
Epstein-Barr virus BZLF1. Interacts with HIRA (via WD repeat domain); the interaction is direct. Interacts with
ASF1A, CEBPA, TJP1, TJP2 and TJP3
Secondary accessions: B7Z6D3 D3DUE8 Q13079 Q9P1P7
Alternative splicing: 2 isoforms:  Q9NPG3-1   Q9NPG3-2   

Explore the universe of human proteins at neXtProt for UBN1: NX_Q9NPG3

Explore proteomics data for UBN1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UBN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001072982.1  NP_001275585.1  

    ENSEMBL proteins: 
     ENSP00000467942   ENSP00000262376   ENSP00000468740   ENSP00000379894   ENSP00000468143  
     ENSP00000465309   ENSP00000468776   ENSP00000442379  
    Reactome Protein details: Q9NPG3

    UBN1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for UBN1
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for UBN1

     
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    UBN1 Assay Products:

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    Cloud-Clone Corp. ELISAs for UBN1
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    Search eBioscience for ELISAs for UBN1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR026936 Ubinuclein-1
     IPR026947 UBN_middle_dom
     IPR026949 Ubinuclein/Yemanuclein
     IPR014840 HRD

    Graphical View of Domain Structure for InterPro Entry Q9NPG3

    ProtoNet protein and cluster: Q9NPG3

    UniProtKB/Swiss-Prot: UBN1_HUMAN, Q9NPG3
    Similarity: Belongs to the ubinuclein family


    Find genes that share domains with UBN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBN1_HUMAN, Q9NPG3
    Function: Acts as a novel regulator of senescence. Involved in the formation of senescence-associated
    heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to
    proliferation-promoting genes. May be required for replication-independent chromatin assembly

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10725330
    GO:0005515protein binding IPI18823282
         
    Find genes that share ontologies with UBN1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBN1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBN1:
    hsa-mir-93-5p (MIRT048870), hsa-mir-18a-3p (MIRT040978), hsa-mir-615-3p (MIRT040198), hsa-mir-335-5p (MIRT017200)

    Block miRNA regulation of human, mouse, rat UBN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBN1 (see all 70):
    hsa-miR-520e hsa-miR-3607-3p hsa-miR-300 hsa-miR-30d hsa-miR-342-3p hsa-miR-4267 hsa-miR-30a hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidUBN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UBN1

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    GenScript: all cDNA clones in your preferred vector (see all 2): UBN1 (NM_016936)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBN1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for UBN1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBN1_HUMAN, Q9NPG3: Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a
    nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML
    bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of
    epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10725330
    GO:0005654nucleoplasm TAS--
    GO:0005923tight junction ISS--
    GO:0016605PML body IEA--

    Find genes that share ontologies with UBN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBN1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81
    2Packaging Of Telomere Ends
    DNA Damage/Telomere Stress Induced Senescence0.65
    Formation of Senescence-Associated Heterochromatin Foci (SAHF)0.00


    Find genes that share SuperPaths with UBN1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for UBN1
        Formation of Senescence-Associated Heterochromatin Foci (SAHF)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBN1
    Interactions:

        Search GeneGlobe Interaction Network for UBN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for UBN1 (Q9NPG32, 3 ENSP000002623764) via UniProtKB, MINT, STRING, and/or I2D (see all 560)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    TJP1Q071573, ENSP000002815374I2D: score=1 STRING: ENSP00000281537
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    HIRAP541982, ENSP000002632084MINT-7947479 STRING: ENSP00000263208
    PPP1CAP621362, ENSP000003260314MINT-7947479 STRING: ENSP00000326031
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10725330
    GO:0010923negative regulation of phosphatase activity IDA19389623
    GO:0016032viral process IEA--
    GO:0016568chromatin modification IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    Find genes that share ontologies with UBN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBN1 gene (3 alternative transcripts): 
    NM_016936.3  NM_001079514.2  NM_001288656.1  

    Unigene Cluster for UBN1:

    Ubinuclein 1
    Hs.440219  [show with all ESTs]
    Unigene Representative Sequence: NM_016936
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592120 ENST00000262376(uc002cyb.3) ENST00000590769 ENST00000396658(uc002cyc.3)
    ENST00000587027 ENST00000585857 ENST00000586716 ENST00000589191 ENST00000586152
    ENST00000545171(uc010uxw.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UBN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBN1 (see all 70):
    hsa-miR-520e hsa-miR-3607-3p hsa-miR-300 hsa-miR-30d hsa-miR-342-3p hsa-miR-4267 hsa-miR-30a hsa-miR-376a*
    SwitchGear 3'UTR luciferase reporter plasmidUBN1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UBN1
    Predesigned siRNA for gene silencing in human, mouse, rat UBN1
    Clone
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    OriGene ORF clones in mouse, rat for UBN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UBN1 (NM_016936)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBN1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for UBN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBN1
      QuantiTect SYBR Green Assays in human, mouse, rat UBN1
      QuantiFast Probe-based Assays in human, mouse, rat UBN1

    Additional mRNA sequence: 

    AF108460.1 AF108461.1 AK022652.1 AK056282.1 AK300131.1 BC013750.1 U19346.1 

    17 DOTS entries:

    DT.86847091  DT.314188  DT.100782121  DT.95111280  DT.100782119  DT.426270  DT.40108357  DT.120704543 
    DT.120704708  DT.91664290  DT.92439823  DT.97822528  DT.205267  DT.40109542  DT.91728209  DT.92439817 
    DT.91727203 

    Selected AceView cDNA sequences (see all 282):

    BE674856 U19346 BE048716 AI114580 BQ000916 CR625373 CA975889 CA776346 
    AW951879 BM666068 AI141460 AA143803 AU120544 AI478306 AI886155 BF197433 
    AI380170 BM802042 AI085355 AA299786 AA557527 BC013750 BF432008 BM541970 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBN1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:        -                       -                                                                                                                           
    SP2:                                -                                                                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                        -                                                   
    SP5:                                                                                                                                      -                     

    ExUns: 19b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for UBN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAGGCAGA
    UBN1 Expression
    About this image


    UBN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Umbilical Cord (Extraembryonic Tissues)
    UBN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440219

    UniProtKB/Swiss-Prot: UBN1_HUMAN, Q9NPG3
    Tissue specificity: Ubiquitous. Also expressed in numerous tumors and cancer cell lines

        Custom PCR Arrays for UBN1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UBN1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubn11 , 5 ubinuclein 11, 5 85.76(n)1
    87.36(a)1
      16 (2.49 cM)5
    1706441  NM_026666.31  NP_080942.11 
     50500685 
    chicken
    (Gallus gallus)
    Aves UBN11 ubinuclein 1 72.25(n)
    71.84(a)
      416398  NM_001079718.1  NP_001073186.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBN16
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL343263.1(1285491-1298519)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ubn11 ubinuclein 1 55.36(n)
    49.55(a)
      100380192  XM_004918112.1  XP_004918169.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.72952 Transcribed sequence with weak similarity to protein more 75.1(n)    CB359535.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta yemalpha6
    yemanuclein alpha
    19(a)
    1 → many
    3R(24944052-24948601)


    ENSEMBL Gene Tree for UBN1 (if available)
    TreeFam Gene Tree for UBN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBN1 gene
    UBN22  
    1 SIMAP similar gene for UBN1 using alignment to 5 protein entries:     UBN1_HUMAN (see all proteins):
    UBN2

    Find genes that share paralogs with UBN1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for UBN1
    PGOHUM00000241727


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBN1 (see all 1153)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1149494911,2
    F--4862230(+) TTCATA/CAACCT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1473543351,2
    C--4862291(+) TACTG-/CATTGC 1 -- us2k10--------
    rs598828011,2
    C,F--4862322(+) CTAGGG/AGAAAA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1506723431,2
    --4862323(+) TAGGGG/TAAAAA 1 -- us2k10--------
    rs1407933441,2
    C--4862344(+) TGCCAC/TCTGAA 1 -- us2k10--------
    rs735170301,2
    C--4862397(+) TCTTAC/GATTCT 1 -- us2k13Minor allele frequency- G:0.02WA EU 713
    rs2018733741,2
    C--4862483(+) CGGCCA/G/TAGTTT 1 -- us2k10--------
    rs1138323891,2
    C--4862509(+) ACAAAC/GAGTCA 1 -- us2k12Minor allele frequency- G:0.33CSA 3
    rs2012164811,2
    C--4862511(+) AAAGAA/GTCAAC 1 -- us2k10--------
    rs1883567271,2
    C--4862516(+) GTCAAC/GACTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBN1 (4896666 - 4932363 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for UBN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv998381CNV Deletion20482838
    esv2422516CNV Deletion17116639
    nsv905254CNV Loss21882294
    nsv905253CNV Loss21882294
    nsv1720CNV Loss18451855
    nsv510674CNV Loss20534489
    nsv905252CNV Loss21882294
    esv25186CNV Gain19812545
    esv26756CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609771    OMIM disorders: --


    Find genes that share disorders with UBN1           About GenesLikeMe

    Genetic Association Database (GAD): UBN1

    Export disorders for UBN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBN1 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with UBN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors. (PubMed id 10725330)1, 2, 3, 9 Aho S.... Uitto J. (J. Cell Biol. 2000)
    2. Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos). (PubMed id 18823282)1, 2, 9 Aho S.... Gruffat H. (Biol. Cell 2009)
    3. Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. (PubMed id 19029251)1, 2 Banumathy G.... Adams P.D. (Mol. Cell. Biol. 2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. (PubMed id 14718166)1, 2 Tagami H.... Nakatani Y. (Cell 2004)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex. (PubMed id 22401310)1 Tang Y....Marmorstein R. (Biochemistry 2012)
    9. Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1). (PubMed id 22245583)1 Lupo J....Boyer V. (Exp. Cell Res. 2012)
    10. Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. (PubMed id 21807893)1 Rai T.S....Adams P.D. (Mol. Cell. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29855 HGNC: 12506 AceView: UBN1 Ensembl:ENSG00000118900 euGenes: HUgn29855
    ECgene: UBN1 H-InvDB: UBN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBN1 gene:
    Search GeneIP for patents involving UBN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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