UBN1 Gene
protein-coding GIFtS: 49
GCID: GC16P004897
|
|
ubinuclein 1
| |
Aliases
for UBN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubinuclein 11 2 | | VT42 | | Ubiquitously Expressed Nuclear Protein2 3 | | Ubinuclein-11 | | HIRA-Binding Protein2 3 | | Protein VT43 | | VT2 | | |
Export aliases for UBN1 gene to outside databasesPrevious GC identifers: GC16P004921 GC16P004898 GC16P004838 |
Summaries
for UBN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBN1_HUMAN, Q9NPG3Function: Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatinfoci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. Maybe required for replication-independent chromatin assembly
|
Genomic Views
for UBN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBN1 gene promoter:
AREB6 AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3UBN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P004897: view genomic region
(about GC identifiers)
Start:
|
4,896,666 bp from pter |
End:
|
4,932,363 bp from pter |
Size:
|
35,698 bases |
Orientation:
|
plus strand |
|
Proteins
for UBN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBN1_HUMAN, Q9NPG3 (See
protein sequence)Recommended Name: Ubinuclein-1 Size: 1134 amino acids; 121520 Da
Subunit: Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts withEpstein-Barr virus BZLF1. Interacts with HIRA (via WD repeat domain); the interaction is direct. Interacts with ASF1A,CEBPA, TJP1, TJP2 and TJP3
Subcellular location: Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as anuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodiesof senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. Whenoverexpressed, accumulates in the nucleus in cells showing defective cytokinesis
Secondary accessions: B7Z6D3 D3DUE8 Q13079 Q9P1P7Alternative splicing: 2 isoforms: Q9NPG3-1 Q9NPG3-2 Explore the universe of human proteins at neXtProt for UBN1: NX_Q9NPG3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NPG3
UBN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001072982.1 NP_058632.2
ENSEMBL proteins: ENSP00000467942 ENSP00000262376 ENSP00000468740 ENSP00000379894 ENSP00000468143 ENSP00000465309 ENSP00000468776 ENSP00000442379
Human Recombinant Protein Products for UBN1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
UBN1 for ontologies About GeneDecksing
UBN1 Antibody Products:
Assay Products for UBN1: |
Protein
Domains /
Families
for UBN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBN1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NPG3ProtoNet protein and cluster: Q9NPG3 UniProtKB/Swiss-Prot: UBN1_HUMAN, Q9NPG3Similarity: Belongs to the ubinuclein family |
Function
for UBN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: UBN1_HUMAN, Q9NPG3Function: Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatinfoci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. Maybe required for replication-independent chromatin assembly Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
UBN1 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBN1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBN1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): UBN1 (NM_016936) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBN1 |
|
Pathways & Interactions
for UBN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/533 Interacting proteins for UBN1 (Q9NPG32, 3 ENSP000002623764) via UniProtKB, MINT, STRING, and/or I2D (see all 533)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
UBN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBN1
Search CenterWatch for drugs/clinical trials and news about UBN1
|
Transcripts
for UBN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBN1 gene (2 alternative transcripts): NM_001079514.1 NM_016936.3 Unigene Cluster for UBN1: Ubinuclein 1 Hs.440219 [show with all ESTs]Unigene Representative Sequence: NM_01693610 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000592120 ENST00000262376(uc002cyb.3) ENST00000590769 ENST00000396658(uc002cyc.3)
ENST00000587027 ENST00000585857 ENST00000586716 ENST00000589191 ENST00000586152
ENST00000545171(uc010uxw.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBN1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBN1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): UBN1 (NM_016936) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBN1 |
Additional cDNA sequence: AF108460.1 AF108461.1 AK022652.1 AK056282.1 AK300131.1 BC013750.1 U19346.1 18 DOTS entries: DT.86847091 DT.314188 DT.100782121 DT.95111280 DT.100782119 DT.426270 DT.40108357 DT.120704543 DT.120704708 DT.91664290 DT.92439823 DT.97822528 DT.205267 DT.40109542 DT.91728209 DT.92439817 DT.91727203 DT.97820255 24/282 AceView cDNA sequences (see all 282): AI085355 AA143803 H97651 BE206890 AI161172 BQ674242 N92493 AI150333 AI341565 AI478306 CA425831 BU074174 BE674856 AI140304 AA761627 U19346 BM541970 CA975889 BM666068 BI438814 AI432573 BQ962619 BG677604 AU120544
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for UBN1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · |
|---|
|
| SP1: | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
| ExUns: | 19b |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for UBN1
|
Expression
for UBN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAAGGCAGA
About this image
See UBN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBN1
SOURCE GeneReport for Unigene cluster: Hs.440219
UniProtKB/Swiss-Prot: UBN1_HUMAN, Q9NPG3Tissue specificity: Ubiquitous. Also expressed in numerous tumors and cancer cell lines
SABiosciences Custom PCR Arrays for UBN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBN1 |
Orthologs
for UBN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for UBN1 gene from 5/19 species (see all 19) About this table
ENSEMBL Gene Tree for UBN1 (if available)
TreeFam Gene Tree for UBN1 (if available) |
Paralogs
for UBN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBN1 gene
- UBN22
1 SIMAP similar gene for UBN1 using alignment to 5 protein entries: UBN1_HUMAN (see all proteins):UBN2
UBN1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for UBN1
PGOHUM00000241727
|
Genomic Variants
for UBN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBN1 (4896666 - 4932363 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for UBN1
5 CNVs: 72442 5436 72443 72444 72441 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBN1 |
|
Disorders
/ Diseases
for UBN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBN1 for disorders About GeneDecksing
OMIM gene information: 609771
OMIM disorders: --
6  diseases for UBN1: About MalaCardshepatic vein thrombosis laryngotracheitis newcastle disease histoplasmosis
thrombosis hepatitis
Export disorders for UBN1 gene to outside databases
|
Publications
for UBN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBN1 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with UBN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors. (PubMed id 10725330)1, 2, 3, 9 Aho S.... Uitto J. (2000)
- Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NaCos). (PubMed id 18823282)1, 2, 9 Aho S.... Gruffat H. (2009)
- Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. (PubMed id 19029251)1, 2 Banumathy G....Adams P.D. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. (PubMed id 14718166)1, 2 Tagami H.... Nakatani Y. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperon e complex. (PubMed id 22401310)1 Tang Y....Marmorstein R. (2012)
- Identification of new interacting partners of the shut tling protein ubinuclein (Ubn-1). (PubMed id 22245583)1 Lupo J....Boyer V. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
|
External Searches for UBN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBN1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBN1 gene:
Search GeneIP for patents involving UBN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBN1 |
| |
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| |  |  |  |  | | | | |
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 |
 |
 | | | UBN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBN1 |
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