Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBN1 Gene

Aliases for UBN1 Gene

  • Ubinuclein 1 2 3
  • Ubiquitously Expressed Nuclear Protein 3 4
  • HIRA-Binding Protein 3 4
  • Ubinuclein-1 3
  • Protein VT4 4
  • VT4 3
  • VT 3

External Ids for UBN1 Gene

Previous GeneCards Identifiers for UBN1 Gene

  • GC16P004921
  • GC16P004898
  • GC16P004838
  • GC16P004897

Summaries for UBN1 Gene

GeneCards Summary for UBN1 Gene

UBN1 (Ubinuclein 1) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Cellular Senescence. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is UBN2.

UniProtKB/Swiss-Prot for UBN1 Gene

  • Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBN1 Gene

Genomics for UBN1 Gene

Regulatory Elements for UBN1 Gene

Genomic Location for UBN1 Gene

Start:
4,846,665 bp from pter
End:
4,882,401 bp from pter
Size:
35,737 bases
Orientation:
Plus strand

Genomic View for UBN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBN1 Gene

Proteins for UBN1 Gene

  • Protein details for UBN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPG3-UBN1_HUMAN
    Recommended name:
    Ubinuclein-1
    Protein Accession:
    Q9NPG3
    Secondary Accessions:
    • B7Z6D3
    • D3DUE8
    • Q13079
    • Q9P1P7

    Protein attributes for UBN1 Gene

    Size:
    1134 amino acids
    Molecular mass:
    121520 Da
    Quaternary structure:
    • Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with Epstein-Barr virus BZLF1. Interacts with HIRA (via WD repeat domain); the interaction is direct. Interacts with ASF1A, CEBPA, TJP1, TJP2 and TJP3.

    Alternative splice isoforms for UBN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBN1 Gene

Proteomics data for UBN1 Gene at MOPED

Post-translational modifications for UBN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBN1 Gene

No data available for DME Specific Peptides for UBN1 Gene

Domains for UBN1 Gene

Protein Domains for UBN1 Gene

Suggested Antigen Peptide Sequences for UBN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPG3

UniProtKB/Swiss-Prot:

UBN1_HUMAN :
  • Q9NPG3
Family:
  • Belongs to the ubinuclein family.
genes like me logo Genes that share domains with UBN1: view

No data available for Gene Families for UBN1 Gene

Function for UBN1 Gene

Molecular function for UBN1 Gene

UniProtKB/Swiss-Prot Function: Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.

Gene Ontology (GO) - Molecular Function for UBN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 10725330
GO:0005515 protein binding IPI 18823282
genes like me logo Genes that share ontologies with UBN1: view

Animal Model Products

CRISPR Products

miRNA for UBN1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBN1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBN1 Gene

Localization for UBN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBN1 Gene

Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBN1 Gene COMPARTMENTS Subcellular localization image for UBN1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for UBN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10725330
GO:0005654 nucleoplasm TAS --
GO:0005923 bicellular tight junction ISS --
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with UBN1: view

Pathways for UBN1 Gene

genes like me logo Genes that share pathways with UBN1: view

Gene Ontology (GO) - Biological Process for UBN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10725330
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0016032 viral process IEA --
GO:0016568 chromatin modification IEA --
genes like me logo Genes that share ontologies with UBN1: view

Transcripts for UBN1 Gene

Unigene Clusters for UBN1 Gene

Ubinuclein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBN1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for UBN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBN1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - -
SP2: -
SP3:
SP4: -
SP5: -
SP6: -

ExUns: 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for UBN1 Gene

GeneLoc Exon Structure for
UBN1
ECgene alternative splicing isoforms for
UBN1

Expression for UBN1 Gene

mRNA expression in normal human tissues for UBN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBN1 Gene

This gene is overexpressed in Whole Blood (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBN1 Gene

SOURCE GeneReport for Unigene cluster for UBN1 Gene Hs.440219

mRNA Expression by UniProt/SwissProt for UBN1 Gene

Q9NPG3-UBN1_HUMAN
Tissue specificity: Ubiquitous. Also expressed in numerous tumors and cancer cell lines.
genes like me logo Genes that share expressions with UBN1: view

In Situ Assay Products

Orthologs for UBN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBN1 35
  • 99.65 (n)
  • 99.74 (a)
UBN1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBN1 35
  • 85.44 (n)
  • 86.01 (a)
UBN1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBN1 35
  • 88.18 (n)
  • 89.39 (a)
UBN1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubn1 35
  • 85.76 (n)
  • 87.36 (a)
Ubn1 16
Ubn1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBN1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBN1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubn1 35
  • 85.94 (n)
  • 87.8 (a)
chicken
(Gallus gallus)
Aves UBN1 35
  • 72.25 (n)
  • 71.84 (a)
UBN1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBN1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubn1 35
  • 55.36 (n)
  • 49.55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5464 35
zebrafish
(Danio rerio)
Actinopterygii Dr.7295 35
UBN1 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta yemalpha 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for UBN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBN1 Gene

ENSEMBL:
Gene Tree for UBN1 (if available)
TreeFam:
Gene Tree for UBN1 (if available)

Paralogs for UBN1 Gene

Paralogs for UBN1 Gene

Selected SIMAP similar genes for UBN1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for UBN1 Gene

genes like me logo Genes that share paralogs with UBN1: view

Variants for UBN1 Gene

Sequence variations from dbSNP and Humsavar for UBN1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs7928 -- 4,881,957(+) CCCCA(C/T)GTACC utr-variant-3-prime
rs14584 -- 4,881,804(+) AGTAG(C/T)AAAAG utr-variant-3-prime
rs760235 -- 4,873,608(+) CATCC(C/T)TAAGC intron-variant
rs760236 -- 4,880,569(+) TGGTC(A/C)CAGTG utr-variant-3-prime
rs882235 -- 4,881,650(-) AGGGC(A/G)GACAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBN1 Gene

Variant ID Type Subtype PubMed ID
esv26756 CNV Gain+Loss 19812545
esv2422516 CNV Deletion 17116639
nsv510674 CNV Loss 20534489
esv998381 CNV Deletion 20482838
nsv1720 CNV Loss 18451855
esv25186 CNV Gain 19812545
nsv905252 CNV Loss 21882294
nsv905253 CNV Loss 21882294
nsv905254 CNV Loss 21882294

Relevant External Links for UBN1 Gene

HapMap Linkage Disequilibrium report
UBN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBN1 Gene

Disorders for UBN1 Gene

Relevant External Links for UBN1

Genetic Association Database (GAD)
UBN1
genes like me logo Genes that share disorders with UBN1: view

No data available for UniProtKB/Swiss-Prot for UBN1 Gene

Publications for UBN1 Gene

  1. Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors. (PMID: 10725330) Aho S. … Uitto J. (J. Cell Biol. 2000) 2 3 4 23
  2. Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos). (PMID: 18823282) Aho S. … Gruffat H. (Biol. Cell 2009) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. (PMID: 14718166) Tagami H. … Nakatani Y. (Cell 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for UBN1 Gene

Sources for UBN1 Gene

Back to Top

Content