Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UBLCP1 Gene

protein-coding   GIFtS: 51
GCID: GC05P158690

Ubiquitin-Like Domain Containing CTD Phosphatase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ubiquitin-Like Domain Containing CTD Phosphatase 11 2     CPUB12
CTD Phosphatase-Like With Ubiquitin Domain 11 2     CTD-Like Phosphatase Domain-Containing Protein2
Nuclear Proteasome Inhibitor UBLCP12 3     Ubiquitin-Like Domain-Containing CTD Phosphatase 12
EC 3.1.3.163 8     

External Ids:    HGNC: 281101   Entrez Gene: 1345102   Ensembl: ENSG000001643327   OMIM: 6098675   UniProtKB: Q8WVY73   
ORGUL members:         

Export aliases for UBLCP1 gene to outside databases

Previous GC identifers: GC05P158623 GC05P153784


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for UBLCP1 Gene:
UBLCP1 (ubiquitin-like domain containing CTD phosphatase 1) is a protein-coding gene. Diseases associated with UBLCP1 include psoriasis, and atherosclerosis. GO annotations related to this gene include phosphoprotein phosphatase activity.

UniProtKB/Swiss-Prot: UBCP1_HUMAN, Q8WVY7
Function: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The
dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S
proteasome




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBLCP1 gene promoter:
         Sox5   AML1a   Pax-2   Pax-2a   PPAR-gamma1   HSF2   FOXJ2 (long isoform)   PPAR-gamma2   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBLCP1 promoter sequence
   Search Chromatin IP Primers for UBLCP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBLCP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.3

UBLCP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBLCP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P158690:  view genomic region     (about GC identifiers)

Start:
158,690,089 bp from pter      End:
158,713,048 bp from pter
Size:
22,960 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UBCP1_HUMAN, Q8WVY7 (See protein sequence)
Recommended Name: Ubiquitin-like domain-containing CTD phosphatase 1  
Size: 318 amino acids; 36805 Da
Cofactor: Magnesium
3 PDB 3D structures from and Proteopedia for UBLCP1:
2KX3 (3D)        2LGD (3D)        2M17 (3D)    
Secondary accessions: D3DQJ7 Q96DK5

Explore the universe of human proteins at neXtProt for UBLCP1: NX_Q8WVY7

Explore proteomics data for UBLCP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys267, Lys286, Lys292, Lys296
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UBLCP1 (Q8WVY7) (see all 16)
     DYTLFDH  KISRRVK  QYLKEIA  VVNDFDI 


    See UBLCP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_659486.2  
    ENSEMBL proteins: 
     ENSP00000296786  

    UBLCP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UBLCP1
    OriGene Protein Over-expression Lysate for UBLCP1
    OriGene MassSpec for UBLCP1
    OriGene Custom Protein Services for UBLCP1
    GenScript Custom Purified and Recombinant Proteins Services for UBLCP1
    Novus Biologicals UBLCP1 Protein
    Novus Biologicals UBLCP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBLCP1

    UBLCP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UBLCP1
    Novus Biologicals UBLCP1 Antibodies
    Search for Antibodies for UBLCP1 at Abcam
    Cloud-Clone Corp. Antibodies for UBLCP1
    Search ThermoFisher Antibodies for UBLCP1
    LSBio Antibodies in human, mouse, rat for UBLCP1

    UBLCP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBLCP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBLCP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UBLCP1
    Cloud-Clone Corp. CLIAs for UBLCP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CTD: Serine/threonine phosphatases / CTD aspartate-based phosphatases

    4 InterPro protein domains:
     IPR023214 HAD-like_dom
     IPR000626 Ubiquitin_dom
     IPR011943 HAD-SF_hydro_IIID
     IPR004274 NIF

    Graphical View of Domain Structure for InterPro Entry Q8WVY7

    ProtoNet protein and cluster: Q8WVY7

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: UBCP1_HUMAN, Q8WVY7
    Domain: The Ubiquitin-like domain mediates interaction with proteasomes
    Similarity: Contains 1 FCP1 homology domain
    Similarity: Contains 1 ubiquitin-like domain


    UBLCP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBCP1_HUMAN, Q8WVY7
    Function: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The
    dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S
    proteasome
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
    Biophysicochemical properties: pH dependence: Optimum pH is 5.0;

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity IEA--
    GO:0005515protein binding ----
         
    UBLCP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Ublcp1 (no phenotypes)

    UBLCP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBLCP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBLCP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBLCP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBLCP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBLCP1:
    hsa-mir-375 (MIRT019695)

    Block miRNA regulation of human, mouse, rat UBLCP1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate UBLCP1:
    hsa-miR-3671 hsa-miR-3163 hsa-miR-338-5p hsa-miR-607 hsa-miR-3658 hsa-miR-3613-3p hsa-miR-7
    SwitchGear 3'UTR luciferase reporter plasmidUBLCP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UBLCP1
    Predesigned siRNA for gene silencing in human, mouse, rat UBLCP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBLCP1

    Clone
    Products:
         
    OriGene clones in human, mouse for UBLCP1 (see all 7)
    OriGene ORF clones in mouse, rat for UBLCP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBLCP1 (NM_145049)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBLCP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBLCP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UBLCP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for UBLCP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBLCP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UBCP1_HUMAN, Q8WVY7: Nucleus. Note=Colocalizes with nuclear proteasomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    UBLCP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBLCP1
    Interactions:

        Search GeneGlobe Interaction Network for UBLCP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBLCP1 (Q8WVY72, 3 ENSP000002967864) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSC22D4Q9Y3Q82, 3, ENSP000003001814MINT-68079 I2D: score=4 STRING: ENSP00000300181
    PSMD2Q132003, ENSP000003101294I2D: score=3 STRING: ENSP00000310129
    STK3Q131883I2D: score=5 
    CNOT4ENSP000003546734STRING: ENSP00000354673
    KIAA0368ENSP000002593354STRING: ENSP00000259335
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBLCP1 (UBCP1)

    4 HMDB Compounds for UBLCP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UBLCP1 gene: 
    NM_145049.3  

    Unigene Cluster for UBLCP1:

    Ubiquitin-like domain containing CTD phosphatase 1
    Hs.591733  [show with all ESTs]
    Unigene Representative Sequence: NM_145049
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296786(uc003lxq.2) ENST00000521738 ENST00000519276
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UBLCP1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate UBLCP1:
    hsa-miR-3671 hsa-miR-3163 hsa-miR-338-5p hsa-miR-607 hsa-miR-3658 hsa-miR-3613-3p hsa-miR-7
    SwitchGear 3'UTR luciferase reporter plasmidUBLCP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UBLCP1
    Predesigned siRNA for gene silencing in human, mouse, rat UBLCP1
    Clone
    Products:
         
    OriGene clones in human, mouse for UBLCP1 (see all 7)
    OriGene ORF clones in mouse, rat for UBLCP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBLCP1 (NM_145049)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBLCP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBLCP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UBLCP1
    OriGene qSTAR qPCR primer pairs in human, mouse for UBLCP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBLCP1
      QuantiTect SYBR Green Assays in human, mouse, rat UBLCP1
      QuantiFast Probe-based Assays in human, mouse, rat UBLCP1

    Additional mRNA sequence: 

    AK057996.1 AY444562.1 BC013425.2 

    7 DOTS entries:

    DT.75183154  DT.95323289  DT.120862056  DT.427508  DT.95099099  DT.97801491  DT.92451011 

    Selected AceView cDNA sequences (see all 87):

    AI091097 AI094226 BQ929683 BF514582 AI417062 BQ214102 AI424725 AI342484 
    CR615207 AW197950 AI493392 AI122887 AI361998 BQ221331 AI459127 BM715016 
    AW151389 BC013425 AI342470 BQ929938 CD688057 CB995359 AL710857 BU165954 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UBLCP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTATATTG
    UBLCP1 Expression
    About this image


    UBLCP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    UBLCP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBLCP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591733

    UniProtKB/Swiss-Prot: UBCP1_HUMAN, Q8WVY7
    Tissue specificity: Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in
    tumor tissues

        Custom PCR Arrays for UBLCP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UBLCP1
    OriGene qSTAR qPCR primer pairs in human, mouse for UBLCP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBLCP1
    QuantiTect SYBR Green Assays in human, mouse, rat UBLCP1
    QuantiFast Probe-based Assays in human, mouse, rat UBLCP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBLCP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBLCP1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ublcp11 , 5 ubiquitin-like domain containing CTD phosphatase 11, 5 88.26(n)1
    98.11(a)1
      11 (25.94 cM)5
    795601  NM_024475.51  NP_077795.21 
     444545715 
    chicken
    (Gallus gallus)
    Aves UBLCP11 ubiquitin-like domain containing CTD phosphatase 1 84.38(n)
    94.34(a)
      416237  NM_001030613.3  NP_001025784.2 
    lizard
    (Anolis carolinensis)
    Reptilia UBLCP16
    ubiquitin-like domain containing CTD phosphatase 1...
    95(a)
    1 ↔ 1
    GL343205.1(4217432-4239734)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF520774.12   -- 75.9(n)    CF520774.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570592562   -- 75.07(n)    57059256 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ublcp11 Ubiquitin-like domain-containing C-terminal domain more 56.91(n)
    60.77(a)
      42726  NM_142861.4  NP_651118.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G065991 AT4G06599 58.39(n)
    53.27(a)
      826068  NM_178989.3  NP_849320.1 
    rice
    (Oryza sativa)
    Liliopsida Os.165362 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.7(n)    NM_190113.1 


    ENSEMBL Gene Tree for UBLCP1 (if available)
    TreeFam Gene Tree for UBLCP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UBLCP1 (see all 471)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs778824081,2
    C--153782348(+) GGCTTA/CAAATA 1 -- us2k10--------
    rs1875578431,2
    --153782359(+) GAAGCA/GAACTG 1 -- us2k10--------
    rs1446238151,2
    --153782383(+) AAGCAA/GGAGTG 1 -- us2k10--------
    rs1118149471,2
    F--153782546(+) CATGCG/TGAATA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1930291471,2
    C--158688137(+) TGGGGA/CAGATT 1 -- us2k10--------
    rs1830103201,2
    --158688218(+) AACTTC/GTAGAG 1 -- us2k10--------
    rs1419027681,2
    --158688253(+) GTCTTA/CCAACT 1 -- us2k10--------
    rs733077451,2
    C,F--158688338(+) ATGGCC/GAGAGA 1 -- us2k13Minor allele frequency- G:0.21WA 122
    rs1884434231,2
    --158688387(+) AAAAGC/TAGAGT 1 -- us2k10--------
    rs794303921,2
    C--158688512(+) ATTTAG/TACTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBLCP1 (158690089 - 158713048 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for UBLCP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBLCP1
    DNA2.0 Custom Variant and Variant Library Synthesis for UBLCP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609867    OMIM disorders: --

    3 diseases for UBLCP1:    
    About MalaCards
    psoriasis    atherosclerosis    malaria


    UBLCP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UBLCP1
    Human Genome Epidemiology (HuGE) Navigator: UBLCP1 (1 document)

    Export disorders for UBLCP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UBLCP1 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with UBLCP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel RNA polymerase II C-terminal domain phosphatase. (PubMed id 15883030)1, 2, 3, 9 Zheng H.... Mao Y. (Biochem. Biophys. Res. Commun. 2005)
    2. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. (PubMed id 21949367)1, 2 Guo X....Dixon J.E. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Solution structure and Rpn1 interaction of the UBL domain of human RNA polymerase II C-terminal domain phosphatase. (PubMed id 23667555)1 Yun J.H....Lee W. (PLoS ONE 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 134510 HGNC: 28110 AceView: MGC10067 Ensembl:ENSG00000164332 euGenes: HUgn134510
    ECgene: UBLCP1 H-InvDB: UBLCP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UBLCP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UBLCP1 gene:
    Search GeneIP for patents involving UBLCP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for UBLCP1  
     OriGene qPCR primer pairs and template standards for UBLCP1   OriGene Protein Over-expression Lysate for UBLCP1  
     OriGene MassSpec something-or-other for UBLCP1   OriGene clones in human, mouse for UBLCP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for UBLCP1   OriGene Purified Protein for UBLCP1  
     OriGene ORF clones in mouse, rat for UBLCP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UBLCP1   OriGene Custom Protein Services for UBLCP1  

     
     
     Block miRNA regulation of human, mouse, rat UBLCP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UBLCP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBLCP1 Predesigned siRNA for gene silencing in human, mouse, rat UBLCP1
     QuantiFast Probe-based Assays in human, mouse, rat UBLCP1 QuantiTect SYBR Green Assays in human, mouse, rat UBLCP1
     Custom PCR Arrays for UBLCP1 Search Chromatin IP Primers for UBLCP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBLCP1  Search GeneGlobe Interaction Network for UBLCP1
     Regulatory tfbs in UBLCP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UBLCP1 GenScript cDNA clones with any tag delivered in your preferred vector for UBLCP1
     GenScript Custom Assay Services for UBLCP1 GenScript Custom overexpressing Cell Line Services for UBLCP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UBLCP1 (UBCP1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UBLCP1 antibodies
     UBLCP1 proteins
     UBLCP1 lysates
     Search for Antibodies for UBLCP1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for UBLCP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for UBLCP1
     Antibodies for UBLCP1
     ELISAs for UBLCP1
     CLIAs for UBLCP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for UBLCP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBLCP1
     SwitchGear 3'UTR luciferase reporter plasmids for UBLCP1
     SwitchGear Promoter luciferase reporter plasmids for UBLCP1
     Search ThermoFisher Antibodies for UBLCP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBLCP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBLCP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBLCP1
     LSBio Antibodies in human, mouse, rat for UBLCP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UBLCP1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4