Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBLCP1 Gene

Aliases for UBLCP1 Gene

  • Ubiquitin-Like Domain Containing CTD Phosphatase 1 2 3
  • CTD Phosphatase-Like With Ubiquitin Domain 1 2 3
  • Nuclear Proteasome Inhibitor UBLCP1 3 4
  • EC 3.1.3.16 4 64
  • Ubiquitin-Like Domain-Containing CTD Phosphatase 1 3
  • CTD-Like Phosphatase Domain-Containing Protein 3
  • CPUB1 3

External Ids for UBLCP1 Gene

Summaries for UBLCP1 Gene

GeneCards Summary for UBLCP1 Gene

UBLCP1 (Ubiquitin-Like Domain Containing CTD Phosphatase 1) is a Protein Coding gene. GO annotations related to this gene include phosphoprotein phosphatase activity.

UniProtKB/Swiss-Prot for UBLCP1 Gene

  • Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBLCP1 Gene

Genomics for UBLCP1 Gene

Genomic Location for UBLCP1 Gene

Start:
159,263,081 bp from pter
End:
159,286,040 bp from pter
Size:
22,960 bases
Orientation:
Plus strand

Genomic View for UBLCP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBLCP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBLCP1 Gene

Regulatory Elements for UBLCP1 Gene

Proteins for UBLCP1 Gene

  • Protein details for UBLCP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVY7-UBCP1_HUMAN
    Recommended name:
    Ubiquitin-like domain-containing CTD phosphatase 1
    Protein Accession:
    Q8WVY7
    Secondary Accessions:
    • D3DQJ7
    • Q96DK5

    Protein attributes for UBLCP1 Gene

    Size:
    318 amino acids
    Molecular mass:
    36805 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBLCP1 Gene

neXtProt entry for UBLCP1 Gene

Proteomics data for UBLCP1 Gene at MOPED

Post-translational modifications for UBLCP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys267, Lys286, Lys292, and Lys296

Other Protein References for UBLCP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for UBLCP1 Gene

Gene Families for UBLCP1 Gene

HGNC:
  • CTD :Serine/threonine phosphatases / CTD aspartate-based phosphatases

Protein Domains for UBLCP1 Gene

UniProtKB/Swiss-Prot:

UBCP1_HUMAN
Domain:
  • The Ubiquitin-like domain mediates interaction with proteasomes:
    • Q8WVY7
  • Contains 1 FCP1 homology domain.:
    • Q8WVY7
  • Contains 1 ubiquitin-like domain.:
    • Q8WVY7
genes like me logo Genes that share domains with UBLCP1: view

Function for UBLCP1 Gene

Molecular function for UBLCP1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 5.0. {ECO:0000269 PubMed:15883030};
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.

Enzyme Numbers (IUBMB) for UBLCP1 Gene

Gene Ontology (GO) - Molecular Function for UBLCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with UBLCP1: view

miRNA for UBLCP1 Gene

miRTarBase miRNAs that target UBLCP1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBLCP1 Gene

Localization for UBLCP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBLCP1 Gene

Nucleus. Note=Colocalizes with nuclear proteasomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBLCP1 Gene COMPARTMENTS Subcellular localization image for UBLCP1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for UBLCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with UBLCP1: view

Pathways for UBLCP1 Gene

SuperPathways for UBLCP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBLCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with UBLCP1: view

No data available for Pathways by source for UBLCP1 Gene

Compounds for UBLCP1 Gene

(4) HMDB Compounds for UBLCP1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Magnesium
  • Magnesium
7439-95-4
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with UBLCP1: view

Transcripts for UBLCP1 Gene

mRNA/cDNA for UBLCP1 Gene

Unigene Clusters for UBLCP1 Gene

Ubiquitin-like domain containing CTD phosphatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBLCP1 Gene

No ASD Table

Relevant External Links for UBLCP1 Gene

GeneLoc Exon Structure for
UBLCP1
ECgene alternative splicing isoforms for
UBLCP1

Expression for UBLCP1 Gene

mRNA expression in normal human tissues for UBLCP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBLCP1 Gene

SOURCE GeneReport for Unigene cluster for UBLCP1 Gene Hs.591733

mRNA Expression by UniProt/SwissProt for UBLCP1 Gene

Q8WVY7-UBCP1_HUMAN
Tissue specificity: Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumor tissues.
genes like me logo Genes that share expressions with UBLCP1: view

Orthologs for UBLCP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBLCP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBLCP1 36
  • 99.69 (n)
  • 100 (a)
UBLCP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBLCP1 36
  • 95.6 (n)
  • 100 (a)
UBLCP1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBLCP1 36
  • 96.23 (n)
  • 100 (a)
UBLCP1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ublcp1 36
  • 88.26 (n)
  • 98.11 (a)
Ublcp1 16
Ublcp1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBLCP1 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBLCP1 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ublcp1 36
  • 88.99 (n)
  • 98.11 (a)
chicken
(Gallus gallus)
Aves UBLCP1 36
  • 84.38 (n)
  • 94.34 (a)
UBLCP1 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBLCP1 37
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13054 36
ublcp1 36
  • 75.79 (n)
  • 87.11 (a)
zebrafish
(Danio rerio)
Actinopterygii ublcp1 36
  • 73.48 (n)
  • 84.28 (a)
ublcp1 37
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005270 36
  • 57.78 (n)
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ublcp1 36
  • 56.91 (n)
  • 60.77 (a)
Ublcp1 37
  • 57 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3059 36
soybean
(Glycine max)
eudicotyledons Gma.7541 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G06599 36
  • 58.39 (n)
  • 53.27 (a)
rice
(Oryza sativa)
Liliopsida Os.16536 36
Os01g0875400 36
  • 56.04 (n)
  • 51.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToOne
Species with no ortholog for UBLCP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBLCP1 Gene

ENSEMBL:
Gene Tree for UBLCP1 (if available)
TreeFam:
Gene Tree for UBLCP1 (if available)

Paralogs for UBLCP1 Gene

No data available for Paralogs for UBLCP1 Gene

Variants for UBLCP1 Gene

Sequence variations from dbSNP and Humsavar for UBLCP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1060642 -- 159,281,668(+) TGTCC(A/G)TTTCA intron-variant
rs1368437 -- 159,279,971(+) TTTTC(C/G)TAACC intron-variant
rs1368438 -- 159,280,297(+) CACGT(C/T)GGCAT intron-variant
rs1433046 -- 159,283,411(+) GTGAC(C/T)CCAGT intron-variant
rs2277040 -- 159,263,282(-) AGGGC(A/G)GGACC utr-variant-5-prime

Relevant External Links for UBLCP1 Gene

HapMap Linkage Disequilibrium report
UBLCP1

No data available for Structural Variations from Database of Genomic Variants (DGV) for UBLCP1 Gene

Disorders for UBLCP1 Gene

Relevant External Links for UBLCP1

Genetic Association Database (GAD)
UBLCP1
Human Genome Epidemiology (HuGE) Navigator
UBLCP1
genes like me logo Genes that share disorders with UBLCP1: view

No data available for UniProtKB/Swiss-Prot for UBLCP1 Gene

Publications for UBLCP1 Gene

  1. Cloning and characterization of a novel RNA polymerase II C-terminal domain phosphatase. (PMID: 15883030) Zheng H. … Mao Y. (Biochem. Biophys. Res. Commun. 2005) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. (PMID: 21949367) Guo X. … Dixon J.E. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for UBLCP1 Gene

Sources for UBLCP1 Gene

Back to Top

Content