Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBLCP1 Gene

Aliases for UBLCP1 Gene

  • Ubiquitin Like Domain Containing CTD Phosphatase 1 2 3 5
  • Ubiquitin-Like Domain Containing CTD Phosphatase 1 2 3
  • CTD Phosphatase-Like With Ubiquitin Domain 1 2 3
  • Nuclear Proteasome Inhibitor UBLCP1 3 4
  • EC 3.1.3.16 4 63
  • CTD-Like Phosphatase Domain-Containing Protein 3
  • CPUB1 3

External Ids for UBLCP1 Gene

Previous GeneCards Identifiers for UBLCP1 Gene

  • GC05P158623
  • GC05P158690
  • GC05P153784

Summaries for UBLCP1 Gene

GeneCards Summary for UBLCP1 Gene

UBLCP1 (Ubiquitin Like Domain Containing CTD Phosphatase 1) is a Protein Coding gene. GO annotations related to this gene include phosphoprotein phosphatase activity.

UniProtKB/Swiss-Prot for UBLCP1 Gene

  • Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBLCP1 Gene

Genomics for UBLCP1 Gene

Regulatory Elements for UBLCP1 Gene


Promoters for UBLCP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBLCP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBLCP1 Gene

Chromosome:
5
Start:
159,263,081 bp from pter
End:
159,286,040 bp from pter
Size:
22,960 bases
Orientation:
Plus strand

Genomic View for UBLCP1 Gene

Genes around UBLCP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBLCP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBLCP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBLCP1 Gene

Proteins for UBLCP1 Gene

  • Protein details for UBLCP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVY7-UBCP1_HUMAN
    Recommended name:
    Ubiquitin-like domain-containing CTD phosphatase 1
    Protein Accession:
    Q8WVY7
    Secondary Accessions:
    • D3DQJ7
    • Q96DK5

    Protein attributes for UBLCP1 Gene

    Size:
    318 amino acids
    Molecular mass:
    36805 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBLCP1 Gene

neXtProt entry for UBLCP1 Gene

Proteomics data for UBLCP1 Gene at MOPED

Post-translational modifications for UBLCP1 Gene

  • Ubiquitination at Lys 267, Lys 286, Lys 292, and Lys 296
  • Modification sites at PhosphoSitePlus

Other Protein References for UBLCP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UBLCP1 Gene

Gene Families for UBLCP1 Gene

Protein Domains for UBLCP1 Gene

Suggested Antigen Peptide Sequences for UBLCP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVY7

UniProtKB/Swiss-Prot:

UBCP1_HUMAN :
  • The Ubiquitin-like domain mediates interaction with proteasomes.
Domain:
  • The Ubiquitin-like domain mediates interaction with proteasomes.
  • Contains 1 FCP1 homology domain.
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with UBLCP1: view

Function for UBLCP1 Gene

Molecular function for UBLCP1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 5.0. {ECO:0000269 PubMed:15883030};
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.

Enzyme Numbers (IUBMB) for UBLCP1 Gene

Gene Ontology (GO) - Molecular Function for UBLCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity IDA 21949367
genes like me logo Genes that share ontologies with UBLCP1: view
genes like me logo Genes that share phenotypes with UBLCP1: view

Animal Models for UBLCP1 Gene

MGI Knock Outs for UBLCP1:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBLCP1 Gene

Localization for UBLCP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBLCP1 Gene

Nucleus. Note=Colocalizes with nuclear proteasomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBLCP1 Gene COMPARTMENTS Subcellular localization image for UBLCP1 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for UBLCP1 Gene

Pathways & Interactions for UBLCP1 Gene

SuperPathways for UBLCP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBLCP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBLCP1 Gene

Drugs & Compounds for UBLCP1 Gene

(2) Drugs for UBLCP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
Magnesium Nutra 0

(3) Additional Compounds for UBLCP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with UBLCP1: view

Transcripts for UBLCP1 Gene

mRNA/cDNA for UBLCP1 Gene

Unigene Clusters for UBLCP1 Gene

Ubiquitin-like domain containing CTD phosphatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBLCP1 Gene

No ASD Table

Relevant External Links for UBLCP1 Gene

GeneLoc Exon Structure for
UBLCP1
ECgene alternative splicing isoforms for
UBLCP1

Expression for UBLCP1 Gene

mRNA expression in normal human tissues for UBLCP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBLCP1 Gene

This gene is overexpressed in Plasma (11.4) and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBLCP1 Gene



SOURCE GeneReport for Unigene cluster for UBLCP1 Gene Hs.591733

mRNA Expression by UniProt/SwissProt for UBLCP1 Gene

Q8WVY7-UBCP1_HUMAN
Tissue specificity: Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumor tissues.
genes like me logo Genes that share expression patterns with UBLCP1: view

Protein tissue co-expression partners for UBLCP1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for UBLCP1 Gene

Orthologs for UBLCP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBLCP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBLCP1 35
  • 95.6 (n)
  • 100 (a)
UBLCP1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBLCP1 35
  • 96.23 (n)
  • 100 (a)
UBLCP1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ublcp1 35
  • 88.26 (n)
  • 98.11 (a)
Ublcp1 16
Ublcp1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBLCP1 35
  • 99.69 (n)
  • 100 (a)
UBLCP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ublcp1 35
  • 88.99 (n)
  • 98.11 (a)
oppossum
(Monodelphis domestica)
Mammalia UBLCP1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBLCP1 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBLCP1 35
  • 84.38 (n)
  • 94.34 (a)
UBLCP1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBLCP1 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13054 35
ublcp1 35
  • 75.79 (n)
  • 87.11 (a)
zebrafish
(Danio rerio)
Actinopterygii ublcp1 35
  • 73.48 (n)
  • 84.28 (a)
ublcp1 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005270 35
  • 57.78 (n)
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ublcp1 35
  • 56.91 (n)
  • 60.77 (a)
Ublcp1 36
  • 57 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G06599 35
  • 58.39 (n)
  • 53.27 (a)
soybean
(Glycine max)
eudicotyledons Gma.7541 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3059 35
rice
(Oryza sativa)
Liliopsida Os.16536 35
Os01g0875400 35
  • 56.04 (n)
  • 51.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for UBLCP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBLCP1 Gene

ENSEMBL:
Gene Tree for UBLCP1 (if available)
TreeFam:
Gene Tree for UBLCP1 (if available)

Paralogs for UBLCP1 Gene

No data available for Paralogs for UBLCP1 Gene

Variants for UBLCP1 Gene

Sequence variations from dbSNP and Humsavar for UBLCP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1060642 -- 159,281,668(+) TGTCC(A/G)TTTCA intron-variant
rs1368437 -- 159,279,971(+) TTTTC(A/C/G)TAACC intron-variant
rs1368438 -- 159,280,297(+) CACGT(C/T)GGCAT intron-variant
rs3734104 -- 159,270,473(-) CAACT(C/G)ATTAC intron-variant
rs1433046 -- 159,283,411(+) GTGAC(C/T)CCAGT intron-variant

Variation tolerance for UBLCP1 Gene

Residual Variation Intolerance Score: 22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for UBLCP1 Gene

Disorders for UBLCP1 Gene

Relevant External Links for UBLCP1

Genetic Association Database (GAD)
UBLCP1
Human Genome Epidemiology (HuGE) Navigator
UBLCP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBLCP1

No disorders were found for UBLCP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBLCP1 Gene

Publications for UBLCP1 Gene

  1. Cloning and characterization of a novel RNA polymerase II C-terminal domain phosphatase. (PMID: 15883030) Zheng H. … Mao Y. (Biochem. Biophys. Res. Commun. 2005) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates. (PMID: 24811749) Besche H.C. … Goldberg A.L. (EMBO J. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for UBLCP1 Gene

Sources for UBLCP1 Gene

Content