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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBLCP1 Gene

protein-coding   GIFtS: 47
GCID: GC05P158690

Ubiquitin-Like Domain Containing CTD Phosphatase 1

  Search for UBLCP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Like Domain Containing CTD Phosphatase 11 2     CPUB12
CTD Phosphatase-Like With Ubiquitin Domain 11 2     CTD-Like Phosphatase Domain-Containing Protein2
Nuclear Proteasome Inhibitor UBLCP12 3     Ubiquitin-Like Domain-Containing CTD Phosphatase 12
EC 3.1.3.163 8     

External Ids:    HGNC: 281101   Entrez Gene: 1345102   Ensembl: ENSG000001643327   OMIM: 6098675   UniProtKB: Q8WVY73   

Export aliases for UBLCP1 gene to outside databases

Previous GC identifers: GC05P158623 GC05P153784


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UBLCP1 Gene: 
UBLCP1 (ubiquitin-like domain containing CTD phosphatase 1) is a protein-coding gene. GO annotations related to this gene include phosphoprotein phosphatase activity.

UniProtKB/Swiss-Prot: UBCP1_HUMAN, Q8WVY7
Function: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The
dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S
proteasome




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBLCP1 gene promoter:
         Sox5   AML1a   Pax-2   Pax-2a   PPAR-gamma1   HSF2   FOXJ2 (long isoform)   PPAR-gamma2   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBLCP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBLCP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBLCP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.3

UBLCP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBLCP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P158690:  view genomic region     (about GC identifiers)

Start:
158,690,089 bp from pter      End:
158,713,048 bp from pter
Size:
22,960 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBCP1_HUMAN, Q8WVY7 (See protein sequence)
Recommended Name: Ubiquitin-like domain-containing CTD phosphatase 1  
Size: 318 amino acids; 36805 Da
Cofactor: Magnesium
Subcellular location: Nucleus. Note=Colocalizes with nuclear proteasomes
3 PDB 3D structures from and Proteopedia for UBLCP1:
2KX3 (3D)        2LGD (3D)        2M17 (3D)    
Secondary accessions: D3DQJ7 Q96DK5

Explore the universe of human proteins at neXtProt for UBLCP1: NX_Q8WVY7

Explore proteomics data for UBLCP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WVY7

  • 4/16 DME Specific Peptides for UBLCP1 (Q8WVY7) (see all 16)
     DYTLFDH  KISRRVK  QYLKEIA  VVNDFDI 

    UBLCP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBLCP1 Protein Expression
    REFSEQ proteins: NP_659486.2  
    ENSEMBL proteins: 
     ENSP00000296786  

    Human Recombinant Protein Products for UBLCP1: 
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    Novus Biologicals UBLCP1 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBLCP1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    UBLCP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CTD: Serine/threonine phosphatases / CTD aspartate-based phosphatases

    5 InterPro protein domains:
     IPR023214 HAD-like_dom
     IPR000626 Ubiquitin
     IPR011943 HAD-SF_hydro_IIID
     IPR004274 NIF
     IPR019955 Ubiquitin_supergroup

    Graphical View of Domain Structure for InterPro Entry Q8WVY7

    ProtoNet protein and cluster: Q8WVY7

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: UBCP1_HUMAN, Q8WVY7
    Domain: The Ubiquitin-like domain mediates interaction with proteasomes
    Similarity: Contains 1 FCP1 homology domain
    Similarity: Contains 1 ubiquitin-like domain


    UBLCP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBCP1_HUMAN, Q8WVY7
    Function: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The
    dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S
    proteasome
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
    Biophysicochemical properties: pH dependence: Optimum pH is 5.0;

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity IEA--
    GO:0005515protein binding ----
         
    UBLCP1 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidUBLCP1 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBLCP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/13 Interacting proteins for UBLCP1 (Q8WVY72, 3 ENSP000002967864) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSC22D4Q9Y3Q82, 3, ENSP000003001814MINT-68079 I2D: score=4 STRING: ENSP00000300181
    PSMD2Q132003, ENSP000003101294I2D: score=3 STRING: ENSP00000310129
    STK3Q131883I2D: score=5 
    SIRT3ENSP000003721914STRING: ENSP00000372191
    PSMD12ENSP000003484424STRING: ENSP00000348442
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBLCP1 (UBCP1)

    4 HMDB Compounds for UBLCP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about UBLCP1 / UBCP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBLCP1 gene: 
    NM_145049.3  

    Unigene Cluster for UBLCP1:

    Ubiquitin-like domain containing CTD phosphatase 1
    Hs.591733  [show with all ESTs]
    Unigene Representative Sequence: NM_145049
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296786(uc003lxq.2) ENST00000521738 ENST00000519276
    miRNA
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    hsa-miR-3671 hsa-miR-3163 hsa-miR-338-5p hsa-miR-607 hsa-miR-3658 hsa-miR-3613-3p hsa-miR-7
    SwitchGear 3'UTR luciferase reporter plasmidUBLCP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBLCP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBLCP1

    Additional mRNA sequence: 

    AK057996.1 AY444562.1 BC013425.2 

    7 DOTS entries:

    DT.75183154  DT.95323289  DT.120862056  DT.427508  DT.95099099  DT.97801491  DT.92451011 

    24/87 AceView cDNA sequences (see all 87):

    BQ214102 AI424725 AI342484 AW151389 AI342470 BM715016 AI122887 CR615207 
    BF514582 BQ929683 AI417062 AI493392 BC013425 AI361998 BQ221331 AI094226 
    AI459127 AI091097 AW197950 AW292482 AA934424 BX480782 AW275329 AK057996 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBLCP1 expression in normal human tissues (normalized intensities)      UBLCP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTATATTG
    UBLCP1 Expression
    About this image


    UBLCP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow

    See UBLCP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBLCP1

    SOURCE GeneReport for Unigene cluster: Hs.591733

    UniProtKB/Swiss-Prot: UBCP1_HUMAN, Q8WVY7
    Tissue specificity: Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in
    tumor tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBLCP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBLCP1 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ublcp11 , 5 ubiquitin-like domain containing CTD phosphatase 11, 5 88.26(n)1
    98.11(a)1
      11 (25.94 cM)5
    795601  NM_024475.51  NP_077795.21 
     444545715 
    chicken
    (Gallus gallus)
    Aves UBLCP11 ubiquitin-like domain containing CTD phosphatase 1 84.38(n)
    94.34(a)
      416237  NM_001030613.2  NP_001025784.2 
    lizard
    (Anolis carolinensis)
    Reptilia UBLCP16
    Uncharacterized protein
    95(a)
    1 ↔ 1
    GL343205.1(4217432-4239734)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF520774.12   -- 75.9(n)    CF520774.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570592562   -- 75.07(n)    57059256 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66971 CG6697 58.58(n)
    63.11(a)
      42726  NM_142861.3  NP_651118.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G065991 ubiquitin-like domain-containing CTD phosphatase 59.67(n)
    54.43(a)
      826068  NM_178989.3  NP_849320.1 
    rice
    (Oryza sativa)
    Liliopsida Os.165362 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.7(n)    NM_190113.1 


    ENSEMBL Gene Tree for UBLCP1 (if available)
    TreeFam Gene Tree for UBLCP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/471 SNPs in UBLCP1 are shown (see all 471)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs778824081,2
    C--153782348(+) GGCTTA/CAAATA 1 -- us2k10--------
    rs1875578431,2
    --153782359(+) GAAGCA/GAACTG 1 -- us2k10--------
    rs1446238151,2
    --153782383(+) AAGCAA/GGAGTG 1 -- us2k10--------
    rs1118149471,2
    F--153782546(+) CATGCG/TGAATA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1930291471,2
    C--158688137(+) TGGGGA/CAGATT 1 -- us2k10--------
    rs1830103201,2
    --158688218(+) AACTTC/GTAGAG 1 -- us2k10--------
    rs1419027681,2
    --158688253(+) GTCTTA/CCAACT 1 -- us2k10--------
    rs733077451,2
    C,F--158688338(+) ATGGCC/GAGAGA 1 -- us2k13Minor allele frequency- G:0.21WA 122
    rs1884434231,2
    --158688387(+) AAAAGC/TAGAGT 1 -- us2k10--------
    rs794303921,2
    C--158688512(+) ATTTAG/TACTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBLCP1 (158690089 - 158713048 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for UBLCP1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UBLCP1
    DNA2.0 Custom Variant and Variant Library Synthesis for UBLCP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    UBLCP1 for disorders           About MalaCards
    OMIM gene information: 609867    OMIM disorders: --


    UBLCP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UBLCP1
    Human Genome Epidemiology (HuGE) Navigator: UBLCP1 (1 document)

    Export disorders for UBLCP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBLCP1 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with UBLCP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel RNA polymerase II C-terminal domain phosphatase. (PubMed id 15883030)1, 2, 3, 9 Zheng H.... Mao Y. (2005)
    2. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. (PubMed id 21949367)1, 2 Guo X....Dixon J.E. (2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Solution structure and Rpn1 interaction of the UBL dom ain of human RNA polymerase II C-terminal domain phosphatase. (PubMed id 23667555)1 Yun J.H....Lee W. (2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 134510 HGNC: 28110 AceView: MGC10067 Ensembl:ENSG00000164332 euGenes: HUgn134510
    ECgene: UBLCP1 H-InvDB: UBLCP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBLCP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBLCP1 gene:
    Search GeneIP for patents involving UBLCP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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