UBLCP1 Gene
protein-coding GIFtS: 47
GCID: GC05P158690
|
|
ubiquitin-like domain containing CTD phosphatase 1
| |
Aliases
for UBLCP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Like Domain Containing CTD Phosphatase 11 2 | | MGC100671 | | CPUB11 2 | | CTD Phosphatase-Like With Ubiquitin Domain 12 | | Nuclear Proteasome Inhibitor UBLCP12 3 | | CTD-Like Phosphatase Domain-Containing Protein2 | | EC 3.1.3.163 8 | | Ubiquitin-Like Domain-Containing CTD Phosphatase 12 |
Export aliases for UBLCP1 gene to outside databasesPrevious GC identifers: GC05P158623 GC05P153784 |
Summaries
for UBLCP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBCP1_HUMAN, Q8WVY7Function: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. Thedephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome
|
Genomic Views
for UBLCP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBLCP1 gene promoter:
Sox5 AML1a Pax-2 Pax-2a PPAR-gamma1 HSF2 FOXJ2 (long isoform) PPAR-gamma2 FOXJ2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBLCP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBLCP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q33.3 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q33.3UBLCP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P158690: view genomic region
(about GC identifiers)
Start:
|
158,690,089 bp from pter |
End:
|
158,713,048 bp from pter |
Size:
|
22,960 bases |
Orientation:
|
plus strand |
|
Proteins
for UBLCP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBCP1_HUMAN, Q8WVY7 (See
protein sequence)Recommended Name: Ubiquitin-like domain-containing CTD phosphatase 1 Size: 318 amino acids; 36805 Da
Cofactor: Magnesium
Subcellular location: Nucleus. Note=Colocalizes with nuclear proteasomes
2 PDB 3D structures from  and Proteopedia  for UBLCP1:2KX3 (3D)
2LGD (3D)
Secondary accessions: D3DQJ7 Q96DK5Explore the universe of human proteins at neXtProt for UBLCP1: NX_Q8WVY7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WVY7
4/16 DME Specific Peptides for UBLCP1 (Q8WVY7) (see all 16)
UBLCP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_659486.2
ENSEMBL proteins: ENSP00000296786
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
UBLCP1 for ontologies About GeneDecksing
UBLCP1 Antibody Products:
Assay Products for UBLCP1: |
Protein
Domains /
Families
for UBLCP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBLCP1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WVY7ProtoNet protein and cluster: Q8WVY7 1 Blocks protein family: IPB000626 Ubiquitin domain
UniProtKB/Swiss-Prot: UBCP1_HUMAN, Q8WVY7Domain: The Ubiquitin-like domain mediates interaction with proteasomesSimilarity: Contains 1 FCP1 homology domainSimilarity: Contains 1 ubiquitin-like domain |
Function
for UBLCP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBCP1_HUMAN, Q8WVY7Function: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. Thedephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasomeCatalytic activity: A phosphoprotein + H(2)O = a protein + phosphateBiophysicochemical properties: pH dependence: Optimum pH is 5.0;Enzyme Number (IUBMB): EC 3.1.3.161 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBLCP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBLCP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBLCP1 (NM_145049) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBLCP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBLCP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBLCP1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004721 | phosphoprotein phosphatase activity |
IEA | -- |
UBLCP1 for ontologies About GeneDecksing
|
Pathways & Interactions
for UBLCP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBLCP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/13 Interacting proteins for UBLCP1 (Q8WVY72, 3 ENSP000002967864) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
|
Drugs & Compounds
for UBLCP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBLCP1
4 HMDB Compounds for UBLCP1 About this table
Search CenterWatch for drugs/clinical trials and news about UBLCP1 / UBCP1
|
Transcripts
for UBLCP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBLCP1 gene: NM_145049.3 Unigene Cluster for UBLCP1: Ubiquitin-like domain containing CTD phosphatase 1 Hs.591733 [show with all ESTs]Unigene Representative Sequence: NM_1450493 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000296786(uc003lxq.2) ENST00000521738 ENST00000519276
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBLCP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBLCP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBLCP1 (NM_145049) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBLCP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBLCP1 |
Additional cDNA sequence: AK057996.1 AY444562.1 BC013425.2 7 DOTS entries: DT.75183154 DT.95323289 DT.120862056 DT.427508 DT.95099099 DT.97801491 DT.92451011 24/87 AceView cDNA sequences (see all 87): AI091097 AI424725 BQ214102 BQ221331 AW151389 AI342470 AI122887 BC013425 AI361998 AI493392 AI459127 AI342484 BQ929683 BM715016 AW197950 CR615207 BF514582 AI417062 AI094226 AA731945 AW117577 BP371386 BP342656 AW275329
GeneLoc Exon Structure
|
Expression
for UBLCP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBLCP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTATATTG
About this image
See UBLCP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBLCP1
SOURCE GeneReport for Unigene cluster: Hs.591733
UniProtKB/Swiss-Prot: UBCP1_HUMAN, Q8WVY7Tissue specificity: Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumortissues
SABiosciences Custom PCR Arrays for UBLCP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBLCP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBLCP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBLCP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBLCP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBLCP1 |
Orthologs
for UBLCP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBLCP1 gene from 8/29 species (see all 29) About this table
ENSEMBL Gene Tree for UBLCP1 (if available)
TreeFam Gene Tree for UBLCP1 (if available) |
Paralogs
for UBLCP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for UBLCP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBLCP1 (158690089 - 158713048 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBLCP1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBLCP1 |
|
Disorders
/ Diseases
for UBLCP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 UBLCP1 for disorders About MalaCards
UBLCP1 for disorders About GeneDecksing
OMIM gene information: 609867
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: UBLCP1 (1 document)
Export disorders for UBLCP1 gene to outside databases
|
Publications
for UBLCP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBLCP1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with UBLCP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a novel RNA polymerase II C-terminal domain phosphatase. (PubMed id 15883030)1, 2, 3, 9 Zheng H.... Mao Y. (2005)
- UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. (PubMed id 21949367)1, 2 Guo X....Dixon J.E. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for UBLCP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBLCP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBLCP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBLCP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBLCP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBLCP1 gene:
Search GeneIP for patents involving UBLCP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBLCP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UBLCP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBLCP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBLCP1 | | | OriGene Protein Over-expression Lysate for UBLCP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBLCP1 | | OriGene 3'-UTR Clone for UBLCP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBLCP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBLCP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for UBLCP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UBLCP1 | | OriGene Custom Protein Services for UBLCP1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBLCP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBLCP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBLCP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBLCP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBLCP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBLCP1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for UBLCP1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | UBLCP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBLCP1 |
|  |  |  | | | | Search ThermoFisher Antibodies for UBLCP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBLCP1 |
|
|
|
|
