UBL7 Gene
protein-coding GIFtS: 46
GCID: GC15M074738
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|
ubiquitin-like 7 (bone marrow stromal cell-derived)
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Aliases
for UBL7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Like 7 (Bone Marrow Stromal Cell-Derived)1 2 | | MGC144211 | | BMSC-UbP1 2 3 | | TCBA12 | | Bone Marrow Stromal Cell Ubiquitin-Like Protein2 3 | | Ubiquitin-Like Protein 72 | | Ubiquitin-Like Protein SB1322 3 | | BMSCUBP3 |
Export aliases for UBL7 gene to outside databasesPrevious GC identifers: GC15M072526 GC15M051534 |
Summaries
for UBL7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for UBL7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBL7 gene promoter:
AhR Pax-3 HSF2 aMEF-2 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBL7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBL7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q24.1 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q23UBL7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M074738: view genomic region
(about GC identifiers)
Start:
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74,738,318 bp from pter |
End:
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74,753,529 bp from pter |
Size:
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15,212 bases |
Orientation:
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minus strand |
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Proteins
for UBL7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBL7_HUMAN, Q96S82 (See
protein sequence)Recommended Name: Ubiquitin-like protein 7 Size: 380 amino acids; 40510 Da
Subunit: Binds ubiquitin
2 PDB 3D structures from  and Proteopedia  for UBL7:2CWB (3D)
2DEN (3D)
Secondary accessions: D3DW57 Q96I03Explore the universe of human proteins at neXtProt for UBL7: NX_Q96S82
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96S82
UBL7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_116296.1 NP_957717.1
ENSEMBL proteins: ENSP00000456662 ENSP00000456807 ENSP00000457703 ENSP00000457708 ENSP00000378518 ENSP00000354883 ENSP00000454828 ENSP00000457828 ENSP00000457920
Human Recombinant Protein Products:
UBL7 Antibody Products:
Assay Products for UBL7: |
Protein
Domains /
Families
for UBL7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBL7 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q96S82ProtoNet protein and cluster: Q96S82 3 Blocks protein families: IPB000449 Ubiquitin-associated domain IPB000626 Ubiquitin domain IPB001901 Protein secE/sec61-gamma protein
UniProtKB/Swiss-Prot: UBL7_HUMAN, Q96S82Similarity: Contains 1 UBA domainSimilarity: Contains 1 ubiquitin-like domain |
Function
for UBL7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBL7_HUMAN, Q96S82Induction: Down-regulated by phorbol myristate acetate (PMA) in bone marrow stroma cells
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBL7 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBL7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL7 |
|
Pathways & Interactions
for UBL7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBL7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/12 Interacting proteins for UBL7 (Q96S822, 3 ENSP000003548834) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
|
Drugs & Compounds
for UBL7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBL7
Search CenterWatch for drugs/clinical trials and news about UBL7
|
Transcripts
for UBL7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBL7 gene (2 alternative transcripts): NM_032907.3 NM_201265.1 Unigene Cluster for UBL7: Ubiquitin-like 7 (bone marrow stromal cell-derived) Hs.334713 [show with all ESTs]Unigene Representative Sequence: BC0079139 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000565494 ENST00000566365 ENST00000567435 ENST00000565335(uc002axz.1)
ENST00000395081(uc002axw.1) ENST00000361351(uc002axy.1) ENST00000564488(uc002axx.1)
ENST00000565130 ENST00000563081
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBL7 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBL7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): UBL7 (NM_201265) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBL7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBL7 |
Additional cDNA sequence: AY037166.1 BC007913.2 BC030055.1 BC033919.1 19 DOTS entries: DT.101984441 DT.95088499 DT.319852 DT.100798296 DT.121019394 DT.100798292 DT.100037705 DT.100798287 DT.100798302 DT.75168077 DT.97860105 DT.91778214 DT.100798303 DT.121019350 DT.100037715 DT.100037716 DT.100798306 DT.97860107 DT.121019368 24/359 AceView cDNA sequences (see all 359): BU166298 CF126630 BU735625 CF145598 BQ014256 CB216679 AI380881 BG576164 BG478811 BQ961664 CD673115 BU149356 CR624391 AL521100 AI697568 BG574884 BC033919 BE877482 BM669310 BI769568 BI767211 AI695083 BU618704 F02428
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for UBL7 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d | · | 13e | ^ |
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| SP1: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
| ExUns: | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c |
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| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for UBL7
|
Expression
for UBL7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBL7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGTGCCTC
About this image
See UBL7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBL7
SOURCE GeneReport for Unigene cluster: Hs.334713
UniProtKB/Swiss-Prot: UBL7_HUMAN, Q96S82Tissue specificity: Ubiquitous. Highly expressed in heart, skeletal muscle, testis, thyroid and adrenal gland
SABiosciences Custom PCR Arrays for UBL7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBL7
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL7 |
Orthologs
for UBL7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for UBL7 gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for UBL7 (if available)
TreeFam Gene Tree for UBL7 (if available) |
Paralogs
for UBL7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for UBL7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBL7 (74738318 - 74753529 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UBL7
1 Inversion: 37170 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBL7 |
|
Disorders
/ Diseases
for UBL7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBL7 for disorders About GeneDecksing
OMIM gene information: 609748
OMIM disorders: --
4  diseases for UBL7: About MalaCardsdengue hemorrhagic fever hemorrhagic fever dengue shock syndrome thyroiditis
Export disorders for UBL7 gene to outside databases
|
Publications
for UBL7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBL7 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with UBL7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and identification of a novel ubiquitin-like protein, BMSC- UbP, from human bone marrow stromal cells. (PubMed id 12644319)1, 2, 3, 9 Liu S....Cao X. (2003)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Solution structure of the ubiquitin-associated domain of human BMSC- UbP and its complex with ubiquitin. (PubMed id 16731964)1, 2 Chang Y.G.... Hu H.Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for UBL7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBL7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBL7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBL7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBL7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBL7 gene:
Search GeneIP for patents involving UBL7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBL7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for UBL7 | | OriGene Custom Protein Services for UBL7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBL7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBL7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBL7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBL7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBL7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBL7 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL7 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBL7 |
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