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Aliases for UBL7 Gene

Aliases for UBL7 Gene

  • Ubiquitin Like 7 2 3 5
  • Ubiquitin-Like Protein SB132 2 3 4
  • Ubiquitin-Like 7 (Bone Marrow Stromal Cell-Derived) 2 3
  • BMSC-UbP 3 4
  • Bone Marrow Stromal Cell-Derived Ubiquitin-Like 2
  • Bone Marrow Stromal Cell Ubiquitin-Like Protein 4
  • Ubiquitin-Like Protein 7 3
  • Ubiquitin-Like 7 2
  • BMSCUBP 4
  • TCBA1 3

External Ids for UBL7 Gene

Previous GeneCards Identifiers for UBL7 Gene

  • GC15M072526
  • GC15M074738
  • GC15M051534

Summaries for UBL7 Gene

GeneCards Summary for UBL7 Gene

UBL7 (Ubiquitin Like 7) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBL7 Gene

Genomics for UBL7 Gene

Regulatory Elements for UBL7 Gene

Enhancers for UBL7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F074539 1.1 FANTOM5 ENCODE 18.3 -80.8 -80773 4.1 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 EDC3 ISLR ENSG00000260274 UBL7 LOC732265 LOC102723657 LOC105370902 ARID3B GOLGA6A UBL7-AS1
GH15F074525 1.1 Ensembl ENCODE 16.7 -64.8 -64846 1.4 PKNOX1 ZFP64 ARID4B SIN3A YBX1 ZNF2 ZNF48 ZNF121 GLIS2 ELK1 UBL7 ENSG00000212279 EDC3 CLK3 UBL7-AS1 CPLX3 CYP1A1 LOC101929333 RPP25 ARID3B
GH15F074377 1.3 Ensembl ENCODE 12.5 +82.3 82260 2.1 ZNF121 ZFHX2 TBL1XR1 IKZF1 EED EGR2 RELA SEMA7A UBL7 UBL7-AS1 ENSG00000212279 CSK CYP11A1 LOC729739 ENSG00000261384 ENSG00000274937 LOC105370894
GH15F074373 1.2 FANTOM5 ENCODE 12.5 +87.0 86986 2.0 PKNOX1 ARID4B SIN3A ZNF48 ZNF2 GLIS2 ELK1 ZNF143 FOS DEK CSK SEMA7A UBL7 UBL7-AS1 ARID3B ENSG00000212279 CYP11A1 SCAMP2 LOC729739 ISLR
GH15F074375 0.4 ENCODE 12.5 +85.8 85774 0.2 CTCF CBX3 SAP130 KLF17 ARID4B MAX RAD21 RFX5 RELA ZNF664 SEMA7A UBL7 UBL7-AS1 ENSG00000212279 CSK ENSG00000274937 LOC105370894
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UBL7 on UCSC Golden Path with GeneCards custom track

Promoters for UBL7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000238236 -412 2801 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for UBL7 Gene

Chromosome:
15
Start:
74,445,977 bp from pter
End:
74,461,188 bp from pter
Size:
15,212 bases
Orientation:
Minus strand

Genomic View for UBL7 Gene

Genes around UBL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL7 Gene

Proteins for UBL7 Gene

  • Protein details for UBL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S82-UBL7_HUMAN
    Recommended name:
    Ubiquitin-like protein 7
    Protein Accession:
    Q96S82
    Secondary Accessions:
    • D3DW57
    • Q96I03

    Protein attributes for UBL7 Gene

    Size:
    380 amino acids
    Molecular mass:
    40510 Da
    Quaternary structure:
    • Binds ubiquitin.

    Three dimensional structures from OCA and Proteopedia for UBL7 Gene

neXtProt entry for UBL7 Gene

Post-translational modifications for UBL7 Gene

  • Ubiquitination at Lys 11, Lys 20, Lys 44, Lys 71, Lys 92, Lys 100, and Lys 106
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UBL7 Gene

Domains & Families for UBL7 Gene

Suggested Antigen Peptide Sequences for UBL7 Gene

Graphical View of Domain Structure for InterPro Entry

Q96S82

UniProtKB/Swiss-Prot:

UBL7_HUMAN :
  • Contains 1 UBA domain.
Domain:
  • Contains 1 UBA domain.
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with UBL7: view

No data available for Gene Families for UBL7 Gene

Function for UBL7 Gene

Molecular function for UBL7 Gene

UniProtKB/Swiss-Prot Induction:
Down-regulated by phorbol myristate acetate (PMA) in bone marrow stroma cells.

Gene Ontology (GO) - Molecular Function for UBL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with UBL7: view
genes like me logo Genes that share phenotypes with UBL7: view

Animal Model Products

miRNA for UBL7 Gene

miRTarBase miRNAs that target UBL7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBL7 Gene

Localization for UBL7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBL7 Gene COMPARTMENTS Subcellular localization image for UBL7 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBL7 Gene

Pathways & Interactions for UBL7 Gene

SuperPathways for UBL7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBL7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBL7 Gene

Transcripts for UBL7 Gene

Unigene Clusters for UBL7 Gene

Ubiquitin-like 7 (bone marrow stromal cell-derived):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBL7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d · 13e ^
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - -

ExUns: 14a · 14b ^ 15a · 15b · 15c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:

Relevant External Links for UBL7 Gene

GeneLoc Exon Structure for
UBL7
ECgene alternative splicing isoforms for
UBL7

Expression for UBL7 Gene

mRNA expression in normal human tissues for UBL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBL7 Gene

This gene is overexpressed in NK cells (10.1) and Heart (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBL7 Gene



Protein tissue co-expression partners for UBL7 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBL7 Gene:

UBL7

SOURCE GeneReport for Unigene cluster for UBL7 Gene:

Hs.334713

mRNA Expression by UniProt/SwissProt for UBL7 Gene:

Q96S82-UBL7_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in heart, skeletal muscle, testis, thyroid and adrenal gland.
genes like me logo Genes that share expression patterns with UBL7: view

Primer Products

No data available for mRNA differential expression in normal tissues for UBL7 Gene

Orthologs for UBL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBL7 34 35
  • 99.13 (n)
cow
(Bos Taurus)
Mammalia BMSC-UBP 35
  • 98 (a)
OneToOne
UBL7 34
  • 93.25 (n)
dog
(Canis familiaris)
Mammalia UBL7 34 35
  • 92.54 (n)
mouse
(Mus musculus)
Mammalia Ubl7 34 16 35
  • 91.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBL7 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubl7 34
  • 90.26 (n)
oppossum
(Monodelphis domestica)
Mammalia UBL7 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-6703 35
  • 91 (a)
OneToOne
UBL7 34
  • 79.12 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 94 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ubl7 34
  • 69.09 (n)
Str.16741 34
African clawed frog
(Xenopus laevis)
Amphibia MGC69120 34
zebrafish
(Danio rerio)
Actinopterygii ubl7a 34 35
  • 70.12 (n)
ubl7b 35
  • 61 (a)
OneToMany
Dr.15396 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9241 34
Species where no ortholog for UBL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBL7 Gene

ENSEMBL:
Gene Tree for UBL7 (if available)
TreeFam:
Gene Tree for UBL7 (if available)

Paralogs for UBL7 Gene

No data available for Paralogs for UBL7 Gene

Variants for UBL7 Gene

Sequence variations from dbSNP and Humsavar for UBL7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1030889 -- 74,445,608(-) TTTCA(G/T)GGGAA downstream-variant-500B
rs111247659 -- 74,458,679(+) AGAGA(C/T)TCACC intron-variant
rs111423714 -- 74,456,470(+) CCCAG(A/G)CTTGT intron-variant
rs111591708 -- 74,449,354(+) GTGTT(C/G/T)TGGAG splice-acceptor-variant
rs112536890 -- 74,455,893(+) GCCGA(C/G)GCGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBL7 Gene

Variant ID Type Subtype PubMed ID
nsv1121512 CNV deletion 24896259
nsv1122981 CNV deletion 24896259

Variation tolerance for UBL7 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBL7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBL7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBL7 Gene

Disorders for UBL7 Gene

Relevant External Links for UBL7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBL7

No disorders were found for UBL7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBL7 Gene

Publications for UBL7 Gene

  1. Cloning and identification of a novel ubiquitin-like protein, BMSC- UbP, from human bone marrow stromal cells. (PMID: 12644319) Liu S. … Cao X. (Immunol. Lett. 2003) 2 3 4 22 64
  2. Solution structure of the ubiquitin-associated domain of human BMSC- UbP and its complex with ubiquitin. (PMID: 16731964) Chang Y.G. … Hu H.Y. (Protein Sci. 2006) 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for UBL7 Gene

Sources for UBL7 Gene

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