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Aliases for UBL5 Gene

Aliases for UBL5 Gene

  • Ubiquitin-Like 5 2 3
  • HUB1 3 6
  • Ubiquitin-Like Protein 5 3
  • Beacon 3

External Ids for UBL5 Gene

Previous GeneCards Identifiers for UBL5 Gene

  • GC19P010060
  • GC19P010161
  • GC19P009783
  • GC19P009799
  • GC19P009766
  • GC19P009938
  • GC19P009520

Summaries for UBL5 Gene

Entrez Gene Summary for UBL5 Gene

  • This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

GeneCards Summary for UBL5 Gene

UBL5 (Ubiquitin-Like 5) is a Protein Coding gene. Diseases associated with UBL5 include autism spectrum disorder and obesity.

Gene Wiki entry for UBL5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBL5 Gene

Genomics for UBL5 Gene

Regulatory Elements for UBL5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBL5 Gene

9,827,880 bp from pter
9,830,121 bp from pter
2,242 bases
Plus strand

Genomic View for UBL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL5 Gene

Proteins for UBL5 Gene

  • Protein details for UBL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-like protein 5
    Protein Accession:
    Secondary Accessions:
    • Q2NL89

    Protein attributes for UBL5 Gene

    73 amino acids
    Molecular mass:
    8547 Da
    Quaternary structure:
    • Interacts with CLK1, CLK3 and CLK4.

    Three dimensional structures from OCA and Proteopedia for UBL5 Gene

neXtProt entry for UBL5 Gene

Proteomics data for UBL5 Gene at MOPED

Post-translational modifications for UBL5 Gene

  • Ubiquitination at Lys41 and Lys46
  • Modification sites at PhosphoSitePlus

Other Protein References for UBL5 Gene

Antibody Products

No data available for DME Specific Peptides for UBL5 Gene

Domains for UBL5 Gene

Protein Domains for UBL5 Gene

Suggested Antigen Peptide Sequences for UBL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BZL1
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with UBL5: view

No data available for Gene Families for UBL5 Gene

Function for UBL5 Gene

Gene Ontology (GO) - Molecular Function for UBL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 15620657
GO:0031386 protein tag IBA --
genes like me logo Genes that share ontologies with UBL5: view
genes like me logo Genes that share phenotypes with UBL5: view

Animal Model Products

miRNA for UBL5 Gene

miRTarBase miRNAs that target UBL5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBL5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBL5 Gene

Localization for UBL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBL5 Gene


Subcellular locations from

Jensen Localization Image for UBL5 Gene COMPARTMENTS Subcellular localization image for UBL5 gene
Compartment Confidence
extracellular 2
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UBL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA 11161819
genes like me logo Genes that share ontologies with UBL5: view

Pathways for UBL5 Gene

SuperPathways for UBL5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
GO:0006464 cellular protein modification process IBA --
GO:0008150 biological_process ND --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with UBL5: view

No data available for Pathways by source for UBL5 Gene

Transcripts for UBL5 Gene

Unigene Clusters for UBL5 Gene

Ubiquitin-like 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBL5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBL5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9: -

Relevant External Links for UBL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBL5 Gene

mRNA expression in normal human tissues for UBL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for UBL5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBL5 Gene

SOURCE GeneReport for Unigene cluster for UBL5 Gene Hs.534477

mRNA Expression by UniProt/SwissProt for UBL5 Gene

Tissue specificity: Ubiquitous. Highest level of expression in heart, skeletal muscle, kidney, liver, iris and lymphoblasts.
genes like me logo Genes that share expressions with UBL5: view

Expression partners for UBL5 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UBL5 Gene

Orthologs for UBL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UBL5 35
  • 94.52 (n)
  • 100 (a)
UBL5 36
  • 99 (a)
(Canis familiaris)
Mammalia UBL5 35
  • 95.43 (n)
  • 100 (a)
UBL5 36
  • 100 (a)
(Mus musculus)
Mammalia Ubl5 35
  • 88.58 (n)
  • 100 (a)
Ubl5 16
Ubl5 36
  • 100 (a)
(Pan troglodytes)
Mammalia UBL5 35
  • 100 (n)
  • 100 (a)
UBL5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ubl5 35
  • 87.67 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia UBL5 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
-- 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubl5 35
  • 80.82 (n)
  • 93.15 (a)
(Danio rerio)
Actinopterygii zgc:66388 35
  • 83.8 (n)
  • 94.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3450 37
  • 86 (a)
ubl 35
  • 74.43 (n)
  • 86.3 (a)
ubl 36
  • 86 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011251 35
  • 75.8 (n)
  • 83.56 (a)
(Caenorhabditis elegans)
Secernentea ubl-5 35
  • 67.12 (n)
  • 80.82 (a)
ubl-5 36
  • 81 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08470g 35
  • 59.72 (n)
  • 62.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUB1 35
  • 62.96 (n)
  • 65.28 (a)
HUB1 36
  • 64 (a)
HUB1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G45180 35
  • 69.91 (n)
  • 79.17 (a)
(Oryza sativa)
Liliopsida Os12g0143150 35
  • 73.61 (n)
  • 80.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hub1 35
  • 69.41 (n)
  • 72.6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 89 (a)
-- 36
  • 54 (a)
Species with no ortholog for UBL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBL5 Gene

Gene Tree for UBL5 (if available)
Gene Tree for UBL5 (if available)

Paralogs for UBL5 Gene Pseudogenes for UBL5 Gene

genes like me logo Genes that share paralogs with UBL5: view

No data available for Paralogs for UBL5 Gene

Variants for UBL5 Gene

Sequence variations from dbSNP and Humsavar for UBL5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2287839 -- 9,830,138(-) CAGCT(C/G)TCATA downstream-variant-500B
rs7259897 -- 9,829,926(+) GGGAC(A/G/T)GAAGT intron-variant
rs10413737 -- 9,828,416(+) AGAGG(C/T)AGTGG intron-variant
rs10418248 -- 9,827,538(+) CTAGT(A/T)GCCGC upstream-variant-2KB
rs10421336 -- 9,829,155(+) GTGCA(A/G)AAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBL5 Gene

Variant ID Type Subtype PubMed ID
nsv520683 CNV Loss 19592680

Relevant External Links for UBL5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBL5 Gene

Disorders for UBL5 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for UBL5 Gene in MalaCards »

(2) Diseases for UBL5 Gene including...

Relevant External Links for UBL5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with UBL5: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for UBL5 Gene

Publications for UBL5 Gene

  1. Structural analysis of UBL5, a novel ubiquitin-like modifier. (PMID: 12824502) McNally T. … Reilly R.M. (Protein Sci. 2003) 3 4 23
  2. Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes. (PMID: 11161819) Friedman J.S. … Walter M.A. (Genomics 2001) 3 4 23
  3. Identification of sequence variants in the UBL5 (ubiquitin-like 5 or BEACON) gene in obese children by PCR-SSCP: no evidence for association with obesity. (PMID: 19189687) Sentinelli F. … Baroni M.G. (J. Pediatr. Endocrinol. Metab. 2008) 3 23 48
  4. Beacon interacts with cdc2/cdc28-like kinases. (PMID: 12705895) Kantham L. … Collier G. (Biochem. Biophys. Res. Commun. 2003) 3 4
  5. Genetic variation in BEACON influences quantitative variation in metabolic syndrome-related phenotypes. (PMID: 15331561) Jowett J.B. … Blangero J. (Diabetes 2004) 3 48

Products for UBL5 Gene

Sources for UBL5 Gene

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