Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBL5 Gene

Aliases for UBL5 Gene

  • Ubiquitin Like 5 2 3 5
  • Testicular Tissue Protein Li 217 3
  • Ubiquitin-Like Protein 5 3
  • Ubiquitin-Like 5 2
  • Beacon 3
  • HUB1 3

External Ids for UBL5 Gene

Previous GeneCards Identifiers for UBL5 Gene

  • GC19P010060
  • GC19P010161
  • GC19P009783
  • GC19P009799
  • GC19P009766
  • GC19P009938
  • GC19P009520

Summaries for UBL5 Gene

Entrez Gene Summary for UBL5 Gene

  • This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

GeneCards Summary for UBL5 Gene

UBL5 (Ubiquitin Like 5) is a Protein Coding gene. Diseases associated with UBL5 include Obesity. GO annotations related to this gene include protein tag.

Gene Wiki entry for UBL5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBL5 Gene

Genomics for UBL5 Gene

Regulatory Elements for UBL5 Gene

Enhancers for UBL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F009798 0.2 Ensembl 12.3 -29.0 -28980 0.6 BCOR OSR2 KDM1A ZNF623 ZKSCAN1 ZNF561 UBL5 ENSG00000266950 ENSG00000200237
GH19F009927 0.5 ENCODE 11.1 +99.8 99763 0.3 SRF PKNOX1 MTA2 NFIA POLR2A EED IKZF1 NBN SPI1 COL5A3 RDH8 C19orf66 UBL5 MRPL4 ICAM1 GC19P009927 OLFM2
GH19F009620 1 FANTOM5 ENCODE 10.7 -206.0 -205990 3.1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF561 ZNF558 FBXL12 EIF3G ENSG00000269300 ZNF699 ZNF846 LOC100128428 MIR1181 LOC100419831
GH19F009625 1.1 Ensembl ENCODE 10.6 -201.9 -201879 0.4 ELF3 CTCF PKNOX1 SAP130 ARID4B ZNF384 RAD21 ZBTB48 GATAD1 SCRT2 ZNF846 UBL5 ZNF561 PIR53474
GH19F009637 0.3 FANTOM5 10.2 -190.6 -190588 0.3 ZNF846 ZNF812P UBL5 ZNF559 PIR53474 ZNF561
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UBL5 on UCSC Golden Path with GeneCards custom track

Promoters for UBL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001015280 -380 2601 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 SLC30A9 KLF13 SP3 SP5

Genomic Location for UBL5 Gene

9,827,880 bp from pter
9,830,121 bp from pter
2,242 bases
Plus strand

Genomic View for UBL5 Gene

Genes around UBL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL5 Gene

Proteins for UBL5 Gene

  • Protein details for UBL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-like protein 5
    Protein Accession:
    Secondary Accessions:
    • Q2NL89

    Protein attributes for UBL5 Gene

    73 amino acids
    Molecular mass:
    8547 Da
    Quaternary structure:
    • Interacts with CLK1, CLK3 and CLK4.

    Three dimensional structures from OCA and Proteopedia for UBL5 Gene

neXtProt entry for UBL5 Gene

Post-translational modifications for UBL5 Gene

  • Ubiquitination at Lys 41 and Lys 46
  • Modification sites at PhosphoSitePlus

Other Protein References for UBL5 Gene

No data available for DME Specific Peptides for UBL5 Gene

Domains & Families for UBL5 Gene

Protein Domains for UBL5 Gene

Suggested Antigen Peptide Sequences for UBL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ubiquitin-like domain.
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with UBL5: view

No data available for Gene Families for UBL5 Gene

Function for UBL5 Gene

Gene Ontology (GO) - Molecular Function for UBL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 15620657
GO:0031386 protein tag IBA --
genes like me logo Genes that share ontologies with UBL5: view
genes like me logo Genes that share phenotypes with UBL5: view

Animal Model Products

miRNA for UBL5 Gene

miRTarBase miRNAs that target UBL5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBL5 Gene

Localization for UBL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBL5 Gene


Subcellular locations from

Jensen Localization Image for UBL5 Gene COMPARTMENTS Subcellular localization image for UBL5 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UBL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA,IDA 11161819
genes like me logo Genes that share ontologies with UBL5: view

Pathways & Interactions for UBL5 Gene

SuperPathways for UBL5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
GO:0006464 cellular protein modification process IBA --
GO:0008150 biological_process ND --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with UBL5: view

No data available for Pathways by source and SIGNOR curated interactions for UBL5 Gene

Transcripts for UBL5 Gene

Unigene Clusters for UBL5 Gene

Ubiquitin-like 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBL5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9: -

Relevant External Links for UBL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBL5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBL5 Gene

Protein tissue co-expression partners for UBL5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBL5 Gene:


SOURCE GeneReport for Unigene cluster for UBL5 Gene:


mRNA Expression by UniProt/SwissProt for UBL5 Gene:

Tissue specificity: Ubiquitous. Highest level of expression in heart, skeletal muscle, kidney, liver, iris and lymphoblasts.
genes like me logo Genes that share expression patterns with UBL5: view

Primer Products

No data available for mRNA differential expression in normal tissues for UBL5 Gene

Orthologs for UBL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBL5 34 35
  • 100 (n)
(Monodelphis domestica)
Mammalia UBL5 35
  • 96 (a)
(Canis familiaris)
Mammalia UBL5 34 35
  • 95.43 (n)
(Bos Taurus)
Mammalia UBL5 34 35
  • 94.52 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
-- 35
  • 88 (a)
(Mus musculus)
Mammalia Ubl5 34 16 35
  • 88.58 (n)
(Rattus norvegicus)
Mammalia Ubl5 34
  • 87.67 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubl5 34
  • 80.82 (n)
(Danio rerio)
Actinopterygii zgc:66388 34
  • 83.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3450 36
  • 86 (a)
ubl 34 35
  • 74.43 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011251 34
  • 75.8 (n)
(Caenorhabditis elegans)
Secernentea ubl-5 34 35
  • 67.12 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUB1 34 35 37
  • 62.96 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08470g 34
  • 59.72 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G45180 34
  • 69.91 (n)
(Oryza sativa)
Liliopsida Os12g0143150 34
  • 73.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 89 (a)
-- 35
  • 54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hub1 34
  • 69.41 (n)
Species where no ortholog for UBL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBL5 Gene

Gene Tree for UBL5 (if available)
Gene Tree for UBL5 (if available)

Paralogs for UBL5 Gene Pseudogenes for UBL5 Gene

genes like me logo Genes that share paralogs with UBL5: view

No data available for Paralogs for UBL5 Gene

Variants for UBL5 Gene

Sequence variations from dbSNP and Humsavar for UBL5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10413737 -- 9,828,416(+) AGAGG(C/T)AGTGG intron-variant
rs10418248 -- 9,827,538(+) CTAGT(A/T)GCCGC upstream-variant-2KB
rs10421336 -- 9,829,155(+) GTGCA(A/G)AAGGA intron-variant
rs111859267 -- 9,830,609(+) TGGCA(-/T)TTTTT downstream-variant-500B
rs113823457 -- 9,830,521(+) AATTG(A/C)GTTTA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for UBL5 Gene

Variant ID Type Subtype PubMed ID
nsv520683 CNV loss 19592680

Variation tolerance for UBL5 Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBL5 Gene

Disorders for UBL5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBL5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards
Search UBL5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for UBL5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with UBL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBL5 Gene

Publications for UBL5 Gene

  1. Identification of sequence variants in the UBL5 (ubiquitin-like 5 or BEACON) gene in obese children by PCR-SSCP: no evidence for association with obesity. (PMID: 19189687) Sentinelli F. … Baroni M.G. (J. Pediatr. Endocrinol. Metab. 2008) 3 22 46 64
  2. Structural analysis of UBL5, a novel ubiquitin-like modifier. (PMID: 12824502) McNally T. … Reilly R.M. (Protein Sci. 2003) 3 4 22 64
  3. Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes. (PMID: 11161819) Friedman J.S. … Walter M.A. (Genomics 2001) 3 4 22 64
  4. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M. … van Ree J.M. (Biol. Psychiatry 2009) 3 46 64
  5. Beacon-like/ubiquitin-5-like immunoreactivity is highly expressed in human hypothalamus and increased in haloperidol-treated schizophrenics and a rat model of schizophrenia. (PMID: 18191906) Bernstein H.G. … Bogerts B. (Psychoneuroendocrinology 2008) 3 22 64

Products for UBL5 Gene

Sources for UBL5 Gene

Loading form....