UBL4B Gene
protein-coding GIFtS: 40
GCID: GC01P110655
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ubiquitin-like 4B
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Aliases
for UBL4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Like 4B1 2 | | FLJ256901 | | Ubiquitin-Like Protein 4B2 |
Export aliases for UBL4B gene to outside databasesPrevious GC identifers: GC01P110368 GC01P110456 GC01P108524 |
Summaries
for UBL4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for UBL4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBL4B gene promoter:
AP-2rep Sp1 MyoD LUN-1 HNF-3beta c-Ets-1 AREB6 POU2F1 POU2F1a Cart-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBL4B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBL4B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3UBL4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P110655: view genomic region
(about GC identifiers)
Start:
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110,655,062 bp from pter |
End:
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110,656,569 bp from pter |
Size:
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1,508 bases |
Orientation:
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plus strand |
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Proteins
for UBL4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBL4B_HUMAN, Q8N7F7 (See
protein sequence)Recommended Name: Ubiquitin-like protein 4B Size: 174 amino acids; 19909 Da
Subcellular location: Cytoplasm (By similarity)
Miscellaneous: May have arisen from retrotransposition of the X-linked UBL4A gene during mammalian evolutionExplore the universe of human proteins at neXtProt for UBL4B: NX_Q8N7F7
UBL4B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_981957.1
ENSEMBL proteins: ENSP00000334044
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
UBL4B for ontologies About GeneDecksing
UBL4B Antibody Products:
Assay Products for UBL4B: |
Protein
Domains /
Families
for UBL4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBL4B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N7F7ProtoNet protein and cluster: Q8N7F7 1 Blocks protein family: IPB000626 Ubiquitin domain
UniProtKB/Swiss-Prot: UBL4B_HUMAN, Q8N7F7Similarity: Contains 1 ubiquitin-like domain |
Function
for UBL4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBL4B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBL4B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for UBL4B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBL4B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL4B |
1 GenomeRNAi human phenotype for UBL4B:
|
Pathways & Interactions
for UBL4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBL4B
1 Interacting protein for UBL4B (Q8N7F73) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for UBL4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBL4B
Search CenterWatch for drugs/clinical trials and news about UBL4B
|
Transcripts
for UBL4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBL4B gene: NM_203412.1 Unigene Cluster for UBL4B: Ubiquitin-like 4B Hs.374027 [show with all ESTs]Unigene Representative Sequence: BC0589291 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000334179(uc001dzc.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBL4B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBL4B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBL4B (NM_203412) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBL4B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBL4B |
Additional cDNA sequence: AK098556.1 BC058929.1 1 DOTS entry: DT.100010354 13 AceView cDNA sequences: BC058929 CN485011 AK098556 BI825709 BM563695 BI825184 AA758832 BI830718 BI831145 CA391628 NM_203412 AA608970 BI832232
GeneLoc Exon Structure
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Expression
for UBL4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBL4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See UBL4B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBL4B
SOURCE GeneReport for Unigene cluster: Hs.374027
SABiosciences Custom PCR Arrays for UBL4B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBL4B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBL4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBL4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBL4B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL4B |
Orthologs
for UBL4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for UBL4B gene from 3/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
42(a) |
1 → many |
1(204757557-204766490) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:565966 |
zgc:56596 |
38(a) |
1 → many |
8(53222229-53231342) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG72156 |
-- |
23(a) |
1 → many |
3R(13991164-13992967) |
ENSEMBL Gene Tree for UBL4B (if available)
TreeFam Gene Tree for UBL4B (if available) |
Paralogs
for UBL4B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBL4B gene
- UBL4A2
1 SIMAP similar gene for UBL4B using alignment to 1 protein entry: UBL4B_HUMAN:UBL4A
UBL4B for paralogs About GeneDecksing
|
Genomic Variants
for UBL4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBL4B (110655062 - 110656569 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBL4B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBL4B |
|
Disorders
/ Diseases
for UBL4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 UBL4B for disorders About MalaCards
UBL4B for disorders About GeneDecksing
OMIM gene information: 611127
OMIM disorders: --
Export disorders for UBL4B gene to outside databases
|
Publications
for UBL4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBL4B gene integrated from 9 sources:
(articles sorted by number of sources associating them with UBL4B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Ubl4b, an X-derived retrogene, is specifically expressed in post-meiotic germ cells in mammals. (PubMed id 16872915)1, 3 Yang F....Wang P.J. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for UBL4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing UBL4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBL4B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBL4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBL4B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBL4B gene:
Search GeneIP for patents involving UBL4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBL4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UBL4B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBL4B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBL4B | | | OriGene Protein Over-expression Lysate for UBL4B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBL4B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBL4B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBL4B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBL4B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBL4B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBL4B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBL4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBL4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBL4B |
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 | | | UBL4B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL4B |
|  |  |  | | | | Search ThermoFisher Antibodies for UBL4B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBL4B |
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