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Aliases for UBL4B Gene

Aliases for UBL4B Gene

  • Ubiquitin Like 4B 2 3 5
  • Ubiquitin-Like 4B 2

External Ids for UBL4B Gene

Previous GeneCards Identifiers for UBL4B Gene

  • GC01P110368
  • GC01P110456
  • GC01P110655
  • GC01P108524

Summaries for UBL4B Gene

GeneCards Summary for UBL4B Gene

UBL4B (Ubiquitin Like 4B) is a Protein Coding gene. An important paralog of this gene is UBL4A.

Additional gene information for UBL4B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBL4B Gene

Genomics for UBL4B Gene

Regulatory Elements for UBL4B Gene

Enhancers for UBL4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H110168 0.6 FANTOM5 dbSUPER 54.8 +56.4 56401 0.2 UBL4B KCNC4 KCNC4-AS1 PROK1 PIR31985 GC01P110163
GH01H109788 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.4 -320.3 -320322 6.6 HDGF PKNOX1 ARID4B FEZF1 ZBTB7B ZNF143 FOS REST SMARCB1 ZNF592 CSF1 AHCYL1 GSTM3 ENSG00000235005 UBL4B SYPL2 GSTM2 AMPD2 GNAI3 PIR57260
GH01H110002 1.6 Ensembl ENCODE dbSUPER 9.6 -108.3 -108335 3 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 FOS JUNB RPS27P6 STRIP1 ENSG00000258634 GSTM3 ENSG00000225113 RNU6V CSF1 UBL4B AHCYL1
GH01H109546 1.4 ENCODE dbSUPER 10.4 -564.4 -564398 3.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF766 ENSG00000258634 GNAI3 ENSG00000235005 ENSG00000232971 RPL17P7 UBL4B RPS27P6 GSTM2 SYPL2 GPR61
GH01H109975 1.5 Ensembl ENCODE dbSUPER 9.5 -134.1 -134087 6 HDGF FOXA2 ARNT ARID4B TCF12 GATA2 ATF7 DEK NCOA1 REST RPL17P7 ENSG00000258634 CSF1 ENSG00000273373 UBL4B PIR51421 GC01P109974
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBL4B on UCSC Golden Path with GeneCards custom track

Genomic Locations for UBL4B Gene

Genomic Locations for UBL4B Gene
chr1:110,112,440-110,113,947
(GRCh38/hg38)
Size:
1,508 bases
Orientation:
Plus strand
chr1:110,655,062-110,656,569
(GRCh37/hg19)

Genomic View for UBL4B Gene

Genes around UBL4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBL4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBL4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL4B Gene

Proteins for UBL4B Gene

  • Protein details for UBL4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7F7-UBL4B_HUMAN
    Recommended name:
    Ubiquitin-like protein 4B
    Protein Accession:
    Q8N7F7

    Protein attributes for UBL4B Gene

    Size:
    174 amino acids
    Molecular mass:
    19909 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May have arisen from retrotransposition of the X-linked UBL4A gene during mammalian evolution.

neXtProt entry for UBL4B Gene

Post-translational modifications for UBL4B Gene

No Post-translational modifications

Other Protein References for UBL4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBL4B Gene

Domains & Families for UBL4B Gene

Gene Families for UBL4B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBL4B Gene

Suggested Antigen Peptide Sequences for UBL4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBL4B: view

No data available for UniProtKB/Swiss-Prot for UBL4B Gene

Function for UBL4B Gene

Phenotypes From GWAS Catalog for UBL4B Gene

Gene Ontology (GO) - Molecular Function for UBL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with UBL4B: view
genes like me logo Genes that share phenotypes with UBL4B: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UBL4B Gene

Localization for UBL4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBL4B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBL4B gene
Compartment Confidence
mitochondrion 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (1)
  • Mitochondria (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBL4B: view

Pathways & Interactions for UBL4B Gene

SuperPathways for UBL4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBL4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with UBL4B: view

No data available for Pathways by source and SIGNOR curated interactions for UBL4B Gene

Drugs & Compounds for UBL4B Gene

No Compound Related Data Available

Transcripts for UBL4B Gene

mRNA/cDNA for UBL4B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UBL4B Gene

Ubiquitin-like 4B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBL4B Gene

No ASD Table

Relevant External Links for UBL4B Gene

GeneLoc Exon Structure for
UBL4B
ECgene alternative splicing isoforms for
UBL4B

Expression for UBL4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBL4B Gene

mRNA differential expression in normal tissues according to GTEx for UBL4B Gene

This gene is overexpressed in Testis (x47.8).

NURSA nuclear receptor signaling pathways regulating expression of UBL4B Gene:

UBL4B

SOURCE GeneReport for Unigene cluster for UBL4B Gene:

Hs.374027

Evidence on tissue expression from TISSUES for UBL4B Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with UBL4B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBL4B Gene

Orthologs for UBL4B Gene

This gene was present in the common ancestor of animals.

Orthologs for UBL4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBL4B 33 34
  • 99.03 (n)
dog
(Canis familiaris)
Mammalia UBL4B 33 34
  • 81.59 (n)
cow
(Bos Taurus)
Mammalia UBL4B 33 34
  • 80.08 (n)
mouse
(Mus musculus)
Mammalia Ubl4b 33 16 34
  • 75.11 (n)
oppossum
(Monodelphis domestica)
Mammalia UBL4B 34
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii UBL4A 34
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7215 34
  • 22 (a)
OneToMany
Species where no ortholog for UBL4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBL4B Gene

ENSEMBL:
Gene Tree for UBL4B (if available)
TreeFam:
Gene Tree for UBL4B (if available)

Paralogs for UBL4B Gene

Paralogs for UBL4B Gene

(1) SIMAP similar genes for UBL4B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBL4B: view

Variants for UBL4B Gene

Sequence variations from dbSNP and Humsavar for UBL4B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000714329 -- 110,110,650(+) GCTTG(C/T)AGCCA upstream-variant-2KB
rs1001989186 -- 110,112,194(+) CCCAC(C/T)ACCCT upstream-variant-2KB
rs1002359466 -- 110,111,755(+) AAAAC(A/T)AAAAA upstream-variant-2KB
rs1002522023 -- 110,111,201(+) AGCCA(A/C)GCCTC upstream-variant-2KB
rs1002664868 -- 110,110,951(+) TTGTG(A/T)CAACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UBL4B Gene

Variant ID Type Subtype PubMed ID
nsv2343 CNV insertion 18451855
nsv509424 CNV insertion 20534489

Variation tolerance for UBL4B Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBL4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBL4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBL4B Gene

Disorders for UBL4B Gene

Relevant External Links for UBL4B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBL4B

No disorders were found for UBL4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBL4B Gene

Publications for UBL4B Gene

  1. Ubl4b, an X-derived retrogene, is specifically expressed in post-meiotic germ cells in mammals. (PMID: 16872915) Yang F … Wang PJ (Gene expression patterns : GEP 2007) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson SA … Youle RJ (Nature 2013) 3 60

Products for UBL4B Gene

Sources for UBL4B Gene

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