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Aliases for UBL4A Gene

Aliases for UBL4A Gene

  • Ubiquitin Like 4A 2 3 5
  • Ubiquitin-Like Protein GDX 3 4
  • Ubiquitin-Like 4A 2 3
  • Ubiquitin-Like 4 2 3
  • DXS254E 3 4
  • UBL4 3 4
  • GDX 3 4
  • DX254E 3
  • TMA24 3
  • G6PD 3
  • GET5 3
  • MDY2 3

External Ids for UBL4A Gene

Previous HGNC Symbols for UBL4A Gene

  • UBL4

Previous GeneCards Identifiers for UBL4A Gene

  • GC0XM153276
  • GC0XM153365
  • GC0XM153712
  • GC0XM142288

Summaries for UBL4A Gene

GeneCards Summary for UBL4A Gene

UBL4A (Ubiquitin Like 4A) is a Protein Coding gene. Diseases associated with UBL4A include borderline glaucoma and suppression amblyopia. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include ubiquitin-like protein transferase activity. An important paralog of this gene is UBL4B.

UniProtKB/Swiss-Prot for UBL4A Gene

  • Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting.

Gene Wiki entry for UBL4A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBL4A Gene

Genomics for UBL4A Gene

Regulatory Elements for UBL4A Gene

Promoters for UBL4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBL4A on UCSC Golden Path with GeneCards custom track

Genomic Location for UBL4A Gene

Chromosome:
X
Start:
154,483,717 bp from pter
End:
154,486,670 bp from pter
Size:
2,954 bases
Orientation:
Minus strand

Genomic View for UBL4A Gene

Genes around UBL4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBL4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL4A Gene

Proteins for UBL4A Gene

  • Protein details for UBL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11441-UBL4A_HUMAN
    Recommended name:
    Ubiquitin-like protein 4A
    Protein Accession:
    P11441
    Secondary Accessions:
    • Q5HY80

    Protein attributes for UBL4A Gene

    Size:
    157 amino acids
    Molecular mass:
    17777 Da
    Quaternary structure:
    • Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET4/TRC35.

    Three dimensional structures from OCA and Proteopedia for UBL4A Gene

neXtProt entry for UBL4A Gene

Proteomics data for UBL4A Gene at MOPED

Post-translational modifications for UBL4A Gene

  • Ubiquitination at Lys 101 and Lys 153
  • Modification sites at PhosphoSitePlus

Other Protein References for UBL4A Gene

Antibody Products

No data available for DME Specific Peptides for UBL4A Gene

Domains & Families for UBL4A Gene

Protein Domains for UBL4A Gene

Suggested Antigen Peptide Sequences for UBL4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11441

UniProtKB/Swiss-Prot:

UBL4A_HUMAN :
  • Contains 1 ubiquitin-like domain.
Domain:
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with UBL4A: view

No data available for Gene Families for UBL4A Gene

Function for UBL4A Gene

Molecular function for UBL4A Gene

UniProtKB/Swiss-Prot Function:
Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting.

Gene Ontology (GO) - Molecular Function for UBL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019787 ubiquitin-like protein transferase activity TAS 2829204
genes like me logo Genes that share ontologies with UBL4A: view
genes like me logo Genes that share phenotypes with UBL4A: view

Animal Models for UBL4A Gene

MGI Knock Outs for UBL4A:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBL4A Gene

Localization for UBL4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBL4A Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBL4A Gene COMPARTMENTS Subcellular localization image for UBL4A gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for UBL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21636303
GO:0005829 cytosol IDA 20676083
genes like me logo Genes that share ontologies with UBL4A: view

Pathways & Interactions for UBL4A Gene

genes like me logo Genes that share pathways with UBL4A: view

Gene Ontology (GO) - Biological Process for UBL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 2829204
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with UBL4A: view

No data available for SIGNOR curated interactions for UBL4A Gene

Drugs & Compounds for UBL4A Gene

No Compound Related Data Available

Transcripts for UBL4A Gene

Unigene Clusters for UBL4A Gene

Ubiquitin-like 4A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBL4A Gene

No ASD Table

Relevant External Links for UBL4A Gene

GeneLoc Exon Structure for
UBL4A
ECgene alternative splicing isoforms for
UBL4A

Expression for UBL4A Gene

mRNA expression in normal human tissues for UBL4A Gene

Protein differential expression in normal tissues from HIPED for UBL4A Gene

This gene is overexpressed in Bone (21.4) and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBL4A Gene



SOURCE GeneReport for Unigene cluster for UBL4A Gene Hs.76480

genes like me logo Genes that share expression patterns with UBL4A: view

Protein tissue co-expression partners for UBL4A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBL4A Gene

Orthologs for UBL4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBL4A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBL4A 35
  • 84.93 (n)
  • 86.62 (a)
-- 36
  • 69 (a)
OneToMany
UBL4A 36
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia UBL4A 35
  • 88.96 (n)
  • 89.17 (a)
UBL4A 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc10a3-ubl4 35
  • 85.56 (n)
  • 89.81 (a)
Ubl4a 16
Ubl4 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBL4A 35
  • 100 (n)
  • 100 (a)
UBL4A 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubl4a 35
  • 84.93 (n)
  • 88.54 (a)
oppossum
(Monodelphis domestica)
Mammalia UBL4A 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBL4A 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ubl4a 35
  • 57.31 (n)
  • 59.59 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:56596 35
  • 57.79 (n)
  • 63.64 (a)
UBL4A 36
  • 62 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8734 35
fruit fly
(Drosophila melanogaster)
Insecta CG7215 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDY2 38
Species with no ortholog for UBL4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBL4A Gene

ENSEMBL:
Gene Tree for UBL4A (if available)
TreeFam:
Gene Tree for UBL4A (if available)

Paralogs for UBL4A Gene

Paralogs for UBL4A Gene

(8) SIMAP similar genes for UBL4A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UBL4A: view

Variants for UBL4A Gene

Sequence variations from dbSNP and Humsavar for UBL4A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs11689 -- 154,484,040(-) GCCTA(A/C/G/T)CTAAT utr-variant-3-prime
rs1050047 -- 154,485,112(-) AGGCC(A/G)AGTGA utr-variant-3-prime
rs1063451 -- 154,484,549(-) CATGG(A/G/T)CTGGG utr-variant-3-prime
rs3174486 -- 154,484,758(-) CTTGT(C/T)TCGTC utr-variant-3-prime
rs3179869 -- 154,483,719(-) GGTCA(A/G)AACTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBL4A Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv33784 CNV Gain+Loss 17666407
nsv519042 CNV Gain 19592680

Variation tolerance for UBL4A Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.50; 77.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBL4A Gene

HapMap Linkage Disequilibrium report
UBL4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBL4A Gene

Disorders for UBL4A Gene

MalaCards: The human disease database

(6) MalaCards diseases for UBL4A Gene - From: DISEASES

Disorder Aliases PubMed IDs
borderline glaucoma
  • preglaucoma
suppression amblyopia
  • strabismic amblyopia
glaucoma 1, open angle, e
  • primary open angle glaucoma
optic disk drusen
  • drusen of optic disc
neuroretinitis
  • focal retinitis and retinochoroiditis, juxtapapillary
- elite association - COSMIC cancer census association via MalaCards
Search UBL4A in MalaCards View complete list of genes associated with diseases

Relevant External Links for UBL4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBL4A
genes like me logo Genes that share disorders with UBL4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBL4A Gene

Publications for UBL4A Gene

  1. A 'housekeeping' gene on the X chromosome encodes a protein similar to ubiquitin. (PMID: 2829204) Toniolo D. … Alcalay M. (Proc. Natl. Acad. Sci. U.S.A. 1988) 2 3 4 67
  2. Ubl4b, an X-derived retrogene, is specifically expressed in post-meiotic germ cells in mammals. (PMID: 16872915) Yang F. … Wang P.J. (Gene Expr. Patterns 2007) 2 3
  3. Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain. (PMID: 25535373) Mock J.Y. … Clemons W.M. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3
  4. Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis. (PMID: 25713138) Kuwabara N. … Kato R. (J. Biol. Chem. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for UBL4A Gene

Sources for UBL4A Gene

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