Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UBL4A Gene

protein-coding   GIFtS: 53
GCID: GC0XM153712

Ubiquitin-Like 4A

(Previous name: ubiquitin-like 4)
(Previous symbol: UBL4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ubiquitin-Like 4A1 2     DX254E2 5
UBL41 2 3 5     G6PD2
GDX2 3 5     GET52
Ubiquitin-Like 41 2     MDY22
Ubiquitin-Like Protein GDX2 3     TMA242
DXS254E2 3     Ubiquitin-Like Protein 4A2

External Ids:    HGNC: 125051   Entrez Gene: 82662   Ensembl: ENSG000001021787   OMIM: 3120705   UniProtKB: P114413   

Export aliases for UBL4A gene to outside databases

Previous GC identifers: GC0XM153276 GC0XM153365 GC0XM142288


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for UBL4A Gene:
UBL4A (ubiquitin-like 4A) is a protein-coding gene. Diseases associated with UBL4A include emery-dreifuss muscular dystrophy, and centronuclear myopathy. GO annotations related to this gene include small conjugating protein ligase activity. An important paralog of this gene is UBL4B.

UniProtKB/Swiss-Prot: UBL4A_HUMAN, P11441
Function: Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of
tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type
II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA
proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the
transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting

Gene Wiki entry for UBL4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011681.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBL4A gene promoter:
         p53   HOXA3   ATF-2   MIF-1   E47   Arnt   GATA-2   CREB   c-Jun   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for UBL4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBL4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

UBL4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBL4A gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM153712:  view genomic region     (about GC identifiers)

Start:
153,712,056 bp from pter      End:
153,715,009 bp from pter
Size:
2,954 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UBL4A_HUMAN, P11441 (See protein sequence)
Recommended Name: Ubiquitin-like protein 4A  
Size: 157 amino acids; 17777 Da
Subunit: Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET4/TRC35
1 PDB 3D structure from and Proteopedia for UBL4A:
2DZI (3D)    
Secondary accessions: Q5HY80

Explore the universe of human proteins at neXtProt for UBL4A: NX_P11441

Explore proteomics data for UBL4A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys101, Lys153
  • Modification sites at PhosphoSitePlus

  • See UBL4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055050.1  
    ENSEMBL proteins: 
     ENSP00000358674   ENSP00000396237   ENSP00000358667   ENSP00000397223  

    UBL4A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for UBL4A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for UBL4A
    GenScript Custom Purified and Recombinant Proteins Services for UBL4A
    Novus Biologicals UBL4A Proteins
    Novus Biologicals UBL4A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for UBL4A
    Cloud-Clone Corp. Proteins for UBL4A

    UBL4A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UBL4A
    OriGene Custom Antibody Services for UBL4A
    Novus Biologicals UBL4A Antibodies
    Abcam antibodies for UBL4A
    Cloud-Clone Corp. Antibodies for UBL4A
    ThermoFisher Antibodies for UBL4A
    LSBio Antibodies in human, mouse, rat for UBL4A

    UBL4A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBL4A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBL4A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UBL4A
    Cloud-Clone Corp. CLIAs for UBL4A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR019954 Ubiquitin_CS
     IPR000626 Ubiquitin_dom
     IPR019956 Ubiquitin

    Graphical View of Domain Structure for InterPro Entry P11441

    ProtoNet protein and cluster: P11441

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: UBL4A_HUMAN, P11441
    Similarity: Contains 1 ubiquitin-like domain


    UBL4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBL4A_HUMAN, P11441
    Function: Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of
    tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type
    II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA
    proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the
    transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019787small conjugating protein ligase activity TAS2829204
         
    UBL4A for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Ubl4):
     normal 

    UBL4A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ubl4tm1.1Xya for UBL4A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBL4A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBL4A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBL4A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBL4A

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBL4A:
    hsa-mir-1 (MIRT002956), hsa-mir-92b-3p (MIRT040672), hsa-mir-26b-5p (MIRT029662), hsa-mir-335-5p (MIRT018235)

    Block miRNA regulation of human, mouse, rat UBL4A using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate UBL4A:
    hsa-miR-194* hsa-miR-324-3p hsa-miR-542-3p hsa-miR-3144-5p
    SwitchGear 3'UTR luciferase reporter plasmidUBL4A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UBL4A
    Predesigned siRNA for gene silencing in human, mouse, rat UBL4A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBL4A

    Clone
    Products:
         
    OriGene clones in human, mouse for UBL4A (see all 6)
    OriGene ORF clones in mouse, rat for UBL4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBL4A (NM_014235)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBL4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBL4A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UBL4A
    Browse ESI BIO Cell Lines and PureStem Progenitors for UBL4A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL4A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UBL4A_HUMAN, P11441: Cytoplasm, cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum2
    nucleus2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA--
    GO:0071818BAT3 complex IDA--

    UBL4A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBL4A
    Interactions:

        Search GeneGlobe Interaction Network for UBL4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBL4A (P114411, 2, 3 ENSP000003586744) via UniProtKB, MINT, STRING, and/or I2D (see all 843)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48384 I2D: score=2 
    BAG6P463793, ENSP000003651314I2D: score=2 STRING: ENSP00000365131
    ENSG00000096155P463793I2D: score=2 
    ENSG00000227761P463793I2D: score=2 
    ENSG00000228760P463793I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS2829204
    GO:0006810transport IEA--
    GO:0071816tail-anchored membrane protein insertion into ER membrane IMP--

    UBL4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBL4A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UBL4A gene: 
    NM_014235.4  

    Unigene Cluster for UBL4A:

    Ubiquitin-like 4A
    Hs.76480  [show with all ESTs]
    Unigene Representative Sequence: AK000405
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369660(uc004flo.3) ENST00000421431 ENST00000369653 ENST00000477777
    ENST00000417913 ENST00000481237
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UBL4A using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate UBL4A:
    hsa-miR-194* hsa-miR-324-3p hsa-miR-542-3p hsa-miR-3144-5p
    SwitchGear 3'UTR luciferase reporter plasmidUBL4A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UBL4A
    Predesigned siRNA for gene silencing in human, mouse, rat UBL4A
    Clone
    Products:
         
    OriGene clones in human, mouse for UBL4A (see all 6)
    OriGene ORF clones in mouse, rat for UBL4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBL4A (NM_014235)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBL4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBL4A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UBL4A
    OriGene qSTAR qPCR primer pairs in human, mouse for UBL4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBL4A
      QuantiTect SYBR Green Assays in human, mouse, rat UBL4A
      Search QuantiFast Probe-based Assays in human, mouse, rat UBL4A

    Additional mRNA sequence: 

    AK000405.1 AK293227.1 BC020254.1 BC043346.2 BC053589.1 M35604.1 

    14 DOTS entries:

    DT.444636  DT.95342934  DT.100787881  DT.100787879  DT.95143393  DT.121293640  DT.101968200  DT.92325833 
    DT.100720481  DT.91837290  DT.95248880  DT.100787887  DT.95240862  DT.121294239 

    Selected AceView cDNA sequences (see all 310):

    BX414252 BQ882419 BU956649 CB154979 AI383173 AA351045 BE301971 BG675065 
    AI220636 BM810590 CA423533 CK725169 BQ690599 AW291544 AI276131 BQ436650 
    AW328138 CR612889 N80880 BM456776 BM739677 BQ919153 BE018292 BE392481 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UBL4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGGCCTGC
    UBL4A Expression
    About this image

    UBL4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBL4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.76480
        Custom PCR Arrays for UBL4A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UBL4A
    OriGene qSTAR qPCR primer pairs in human, mouse for UBL4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBL4A
    QuantiTect SYBR Green Assays in human, mouse, rat UBL4A
    Search QuantiFast Probe-based Assays in human, mouse, rat UBL4A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for UBL4A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubl45
    Slc10a3-ubl41
    ubiquitin-like 45
    Slc10a3-Ubl4 readthrough1
    85.56(n)1
    89.81(a)1
      X (38.00 cM)5
    1001698641  NM_001278271.11  NP_001265200.11 
     743657185 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    1(204753487-204766490)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ubl4a1 ubiquitin-like 4A 57.31(n)
    59.59(a)
      100125140  NM_001103040.1  NP_001096510.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:565961 zgc:56596 57.79(n)
    63.64(a)
      393270  NM_200300.1  NP_956594.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72156
    --
    30(a)
    1 → many
    3R(13991164-13992967)


    ENSEMBL Gene Tree for UBL4A (if available)
    TreeFam Gene Tree for UBL4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UBL4A gene
    UBL4B2  
    8 SIMAP similar genes for UBL4A using alignment to 4 protein entries:     UBL4A_HUMAN (see all proteins):
    UBL4B    UBA52    NEDD8    RPS27A    UBC    DKFZp434K0435
    UBB    UbC

    UBL4A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UBL4A (see all 63)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895758661,2
    --153711577(+) AGGGCA/GGACAA 1 -- int10--------
    rs1404485881,2
    --153711719(+) CACTTC/TCTGTC 1 -- int10--------
    rs1830918651,2
    --153711834(+) CCTGCA/GAGGTG 1 -- int10--------
    rs1863073441,2
    --153711986(+) GCCTAA/GCTCCA 1 -- int10--------
    rs134409121,2
    C--153712162(+) GGAAGA/CTGCAG 1 -- ut31 ese30--------
    rs116891,2
    C,H--153712379(+) GCCTAG/ACTAAT 1 -- ut316Minor allele frequency- A:0.01MN NS EA NA 604
    rs1911440011,2
    --153712470(+) ACCACA/GCAAAC 1 -- ut310--------
    rs1838489561,2
    C--153712662(+) ACCCAA/GTATTT 1 -- ut310--------
    rs413113921,2
    C--153712689(+) GCAGGA/TGGGCC 1 -- ut310--------
    rs1882938331,2
    --153712705(+) CACGCA/GCAGCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for UBL4A (153712056 - 153715009 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UBL4A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519042CNV Gain19592680
    esv33199CNV Gain+Loss17666407
    esv33784CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBL4A
    DNA2.0 Custom Variant and Variant Library Synthesis for UBL4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 312070    OMIM disorders: --

    7 diseases for UBL4A:    
    About MalaCards
    emery-dreifuss muscular dystrophy    centronuclear myopathy    rett syndrome    myopathy
    muscular dystrophy    glaucoma    hiv-1


    UBL4A for disorders           About GeneDecksing


    Export disorders for UBL4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UBL4A gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with UBL4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A 'housekeeping' gene on the X chromosome encodes a protein similar to ubiquitin. (PubMed id 2829204)1, 2, 3 Toniolo D.... Alcalay M. (Proc. Natl. Acad. Sci. U.S.A. 1988)
    2. A ribosome-associating factor chaperones tail-anchored membrane proteins. (PubMed id 20676083)1, 2 Mariappan M....Hegde R.S. (Nature 2010)
    3. Ubl4b, an X-derived retrogene, is specifically expressed in post-meiotic germ cells in mammals. (PubMed id 16872915)1, 3 Yang F....Wang P.J. (Gene Expr. Patterns 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PubMed id 8733135)1, 2 Chen E.Y....D'Urso M. (Hum. Mol. Genet. 1996)
    6. A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation. (PubMed id 23665563)1 Xu Y....Ye Y. (J. Biol. Chem. 2013)
    7. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. The association of BAG6 with SGTA and tail-anchored proteins. (PubMed id 23533635)1 Leznicki P....High S. (PLoS ONE 2013)
    10. Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death. (PubMed id 23723067)1 Krenciute G....Wang Y. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8266 HGNC: 12505 AceView: UBL4 Ensembl:ENSG00000102178 euGenes: HUgn8266
    ECgene: UBL4A H-InvDB: UBL4A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UBL4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UBL4A gene:
    Search GeneIP for patents involving UBL4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UBL4A   OriGene RNAi products in human, mouse, rat for UBL4A  
     OriGene qPCR primer pairs and template standards for UBL4A   OriGene Protein Over-expression Lysate for UBL4A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UBL4A  
     OriGene qSTAR qPCR primer pairs in human, mouse for UBL4A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for UBL4A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UBL4A   OriGene Custom Protein Services for UBL4A  

     
     
     Block miRNA regulation of human, mouse, rat UBL4A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UBL4A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBL4A Predesigned siRNA for gene silencing in human, mouse, rat UBL4A
     Search QuantiFast Probe-based Assays in human, mouse, rat UBL4A QuantiTect SYBR Green Assays in human, mouse, rat UBL4A
     Custom PCR Arrays for UBL4A Search Chromatin IP Primers for UBL4A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBL4A  Search GeneGlobe Interaction Network for UBL4A
     Regulatory tfbs in UBL4A promoter
     GenScript Custom Purified and Recombinant Proteins Services for UBL4A GenScript cDNA clones with any tag delivered in your preferred vector for UBL4A
     GenScript Custom Assay Services for UBL4A GenScript Custom overexpressing Cell Line Services for UBL4A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UBL4A
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UBL4A antibodies
     UBL4A proteins
     UBL4A lysates
     Antibodies for UBL4A
     See all of Abcam's Antibodies, Kits and Proteins for UBL4A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for UBL4A
     Proteins for UBL4A
     Antibodies for UBL4A
     ELISAs for UBL4A
     CLIAs for UBL4A



     Browse ESI BIO Cell Lines and PureStem Progenitors for UBL4A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL4A
     SwitchGear 3'UTR luciferase reporter plasmids for UBL4A
     Browse SwitchGear Promoter luciferase reporter plasmids for UBL4A
     ThermoFisher Antibodies for UBL4A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBL4A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBL4A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBL4A
     LSBio Antibodies in human, mouse, rat for UBL4A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UBL4A gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4