UBL4A Gene
protein-coding GIFtS: 52
GCID: GC0XM153712
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ubiquitin-like 4A(Previous name: ubiquitin-like 4 )
(Previous symbol: UBL4)
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Aliases
for UBL4A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Like 4A1 2 | | TMA241 2 | | GDX1 2 3 5 | | Ubiquitin-Like 41 2 | | UBL41 2 3 5 | | Ubiquitin-Like Protein GDX2 3 | | DXS254E1 2 3 | | DX254E2 5 | | GET51 2 | | G6PD2 | | MDY21 2 | | Ubiquitin-Like Protein 4A2 |
Export aliases for UBL4A gene to outside databasesPrevious GC identifers: GC0XM153276 GC0XM153365 GC0XM142288 |
Summaries
for UBL4A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBL4A_HUMAN, P11441Function: Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery oftail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type IItransmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteinscapture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembraneregion of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting
Gene Wiki entry for UBL4A
|
Genomic Views
for UBL4A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBL4A gene promoter:
p53 HOXA3 ATF-2 MIF-1 E47 Arnt GATA-2 CREB c-Jun RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBL4A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBL4A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28UBL4A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM153712: view genomic region
(about GC identifiers)
Start:
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153,712,056 bp from pter |
End:
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153,715,009 bp from pter |
Size:
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2,954 bases |
Orientation:
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minus strand |
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Proteins
for UBL4A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBL4A_HUMAN, P11441 (See
protein sequence)Recommended Name: Ubiquitin-like protein 4A Size: 157 amino acids; 17777 Da
Subunit: Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET4/TRC35
Subcellular location: Cytoplasm, cytosol
1 PDB 3D structure from  and Proteopedia  for UBL4A:2DZI (3D)
Secondary accessions: Q5HY80Explore the universe of human proteins at neXtProt for UBL4A: NX_P11441
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P11441
UBL4A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055050.1
ENSEMBL proteins: ENSP00000358674 ENSP00000396237 ENSP00000358667 ENSP00000397223
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
UBL4A for ontologies About GeneDecksing
UBL4A Antibody Products:
Assay Products for UBL4A: |
Protein
Domains /
Families
for UBL4A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBL4A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P11441ProtoNet protein and cluster: P11441 1 Blocks protein family: IPB000626 Ubiquitin domain
UniProtKB/Swiss-Prot: UBL4A_HUMAN, P11441Similarity: Contains 1 ubiquitin-like domain |
Function
for UBL4A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBL4A_HUMAN, P11441Function: Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery oftail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type IItransmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteinscapture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembraneregion of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBL4A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBL4A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL4A |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
UBL4A for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Ubl4tm1.1Xya for UBL4A
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Ubl4):
UBL4A for phenotypes About GeneDecksing
|
Pathways & Interactions
for UBL4A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBL4A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 21)
5/757 Interacting proteins for UBL4A (P114411, 2, 3 ENSP000003586744) via UniProtKB, MINT, STRING, and/or I2D (see all 757)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006464 | cellular protein modification process |
TAS | 2829204 | | GO:0006810 | transport |
IEA | -- | | GO:0071816 | tail-anchored membrane protein insertion into ER membrane |
IMP | -- |
UBL4A for ontologies About GeneDecksing
|
Drugs & Compounds
for UBL4A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBL4A
Search CenterWatch for drugs/clinical trials and news about UBL4A
|
Transcripts
for UBL4A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBL4A gene: NM_014235.3 Unigene Cluster for UBL4A: Ubiquitin-like 4A Hs.76480 [show with all ESTs]Unigene Representative Sequence: AK0004056 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369660(uc004flo.3) ENST00000421431 ENST00000369653 ENST00000477777
ENST00000417913 ENST00000481237
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBL4A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBL4A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBL4A (NM_014235) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBL4A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBL4A |
Additional cDNA sequence: AK000405.1 AK293227.1 BC020254.1 BC043346.2 BC053589.1 M35604.1 14 DOTS entries: DT.444636 DT.95342934 DT.100787881 DT.100787879 DT.95143393 DT.121293640 DT.101968200 DT.92325833 DT.100720481 DT.91837290 DT.95248880 DT.100787887 DT.95240862 DT.121294239 24/310 AceView cDNA sequences (see all 310): T28480 CK826434 BM739677 AA810008 AI685489 BQ109459 BM846384 AI783698 BM740674 BE301681 AI479798 BM738138 BM810590 BU539589 BM759598 AK000405 BE293013 BM705694 BQ436650 AA351045 CR612889 BM667752 BM830184 BQ882208
GeneLoc Exon Structure
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Expression
for UBL4A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBL4A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGGCCTGC
About this image
See UBL4A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBL4A
SOURCE GeneReport for Unigene cluster: Hs.76480
SABiosciences Custom PCR Arrays for UBL4A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBL4A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBL4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBL4A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBL4A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL4A |
Orthologs
for UBL4A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for UBL4A gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for UBL4A (if available)
TreeFam Gene Tree for UBL4A (if available) |
Paralogs
for UBL4A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBL4A gene
- UBL4B2
7 SIMAP similar genes for UBL4A using alignment to 4 protein entries: UBL4A_HUMAN (see all proteins):UBL4B UBA52 NEDD8 RPS27A UBC DKFZp434K0435
UBB
UBL4A for paralogs About GeneDecksing
|
Genomic Variants
for UBL4A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBL4A (153712056 - 153715009 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBL4A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBL4A |
|
Disorders
/ Diseases
for UBL4A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBL4A for disorders About GeneDecksing
OMIM gene information: 312070
OMIM disorders: --
6  diseases for UBL4A: About MalaCardsemery-dreifuss muscular dystrophy centronuclear myopathy rett syndrome muscular dystrophy
glaucoma myopathy
Export disorders for UBL4A gene to outside databases
|
Publications
for UBL4A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBL4A gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with UBL4A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A 'housekeeping' gene on the X chromosome encodes a protein similar to ubiquitin. (PubMed id 2829204)1, 2, 3 Toniolo D.... Alcalay M. (1988)
- A ribosome-associating factor chaperones tail-anchore d membrane proteins. (PubMed id 20676083)1, 2 Mariappan M....Hegde R.S. (2010)
- Ubl4b, an X-derived retrogene, is specifically expressed in post-meiotic germ cells in mammals. (PubMed id 16872915)1, 3 Yang F....Wang P.J. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PubMed id 8733135)1, 2 Chen E.Y....D'Urso M. (1996)
- The human EKC/KEOPS complex is recruited to Cullin2 ub iquitin ligases by the human tumour antigen PRAME. (PubMed id 22912744)1 Costessi A....Stunnenberg H.G. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Vif hijacks CBF-b to degrade APOBEC3G and promote HIV- 1 infection. (PubMed id 22190037)1 Jager S....Krogan N.J. (2012)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
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External Searches for UBL4A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBL4A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBL4A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBL4A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBL4A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBL4A gene:
Search GeneIP for patents involving UBL4A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBL4A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for UBL4A | | OriGene shRNA RFP for UBL4A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBL4A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBL4A | | | OriGene Protein Over-expression Lysate for UBL4A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBL4A | | OriGene 3'-UTR Clone for UBL4A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBL4A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBL4A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UBL4A | | OriGene Custom Protein Services for UBL4A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBL4A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBL4A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBL4A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBL4A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBL4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBL4A |
| |
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| | | | Search Tocris compounds for UBL4A |
| |  |  |  |  | | | | | | Recombinant Protein for UBL4A |
|
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 | | | UBL4A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL4A |
|  |  |  | | | | ThermoFisher Antibodies for UBL4A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBL4A |
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