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Aliases for UBL4A Gene

Aliases for UBL4A Gene

  • Ubiquitin-Like 4A 2 3
  • UBL4 3 4 6
  • GDX 3 4 6
  • Ubiquitin-Like Protein GDX 3 4
  • Ubiquitin-Like 4 2 3
  • DXS254E 3 4
  • DX254E 3 6
  • Ubiquitin-Like Protein 4A 3
  • TMA24 3
  • G6PD 3
  • GET5 3
  • MDY2 3

External Ids for UBL4A Gene

Previous HGNC Symbols for UBL4A Gene

  • UBL4

Previous GeneCards Identifiers for UBL4A Gene

  • GC0XM153276
  • GC0XM153365
  • GC0XM153712
  • GC0XM142288

Summaries for UBL4A Gene

GeneCards Summary for UBL4A Gene

UBL4A (Ubiquitin-Like 4A) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include ubiquitin-like protein transferase activity. An important paralog of this gene is UBL4B.

UniProtKB/Swiss-Prot for UBL4A Gene

  • Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting.

Gene Wiki entry for UBL4A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBL4A Gene

Genomics for UBL4A Gene

Regulatory Elements for UBL4A Gene

Genomic Location for UBL4A Gene

Start:
154,483,717 bp from pter
End:
154,486,670 bp from pter
Size:
2,954 bases
Orientation:
Minus strand

Genomic View for UBL4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL4A Gene

Proteins for UBL4A Gene

  • Protein details for UBL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11441-UBL4A_HUMAN
    Recommended name:
    Ubiquitin-like protein 4A
    Protein Accession:
    P11441
    Secondary Accessions:
    • Q5HY80

    Protein attributes for UBL4A Gene

    Size:
    157 amino acids
    Molecular mass:
    17777 Da
    Quaternary structure:
    • Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET4/TRC35.

    Three dimensional structures from OCA and Proteopedia for UBL4A Gene

neXtProt entry for UBL4A Gene

Proteomics data for UBL4A Gene at MOPED

Post-translational modifications for UBL4A Gene

  • Ubiquitination at Lys101 and Lys153
  • Modification sites at PhosphoSitePlus

Other Protein References for UBL4A Gene

No data available for DME Specific Peptides for UBL4A Gene

Domains for UBL4A Gene

Protein Domains for UBL4A Gene

Suggested Antigen Peptide Sequences for UBL4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11441

UniProtKB/Swiss-Prot:

UBL4A_HUMAN :
  • P11441
Domain:
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with UBL4A: view

No data available for Gene Families for UBL4A Gene

Function for UBL4A Gene

Molecular function for UBL4A Gene

UniProtKB/Swiss-Prot Function: Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting.

Gene Ontology (GO) - Molecular Function for UBL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0019787 ubiquitin-like protein transferase activity TAS 2829204
genes like me logo Genes that share ontologies with UBL4A: view

Phenotypes for UBL4A Gene

MGI mutant phenotypes for UBL4A:
inferred from 2 alleles
genes like me logo Genes that share phenotypes with UBL4A: view

Animal Models for UBL4A Gene

MGI Knock Outs for UBL4A:

miRNA for UBL4A Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for UBL4A Gene

Localization for UBL4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBL4A Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBL4A Gene COMPARTMENTS Subcellular localization image for UBL4A gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 2
nucleus 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UBL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 20676083
GO:0071818 BAT3 complex IDA 20676083
genes like me logo Genes that share ontologies with UBL4A: view

Pathways for UBL4A Gene

genes like me logo Genes that share pathways with UBL4A: view

Gene Ontology (GO) - Biological Process for UBL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 2829204
GO:0006810 transport IEA --
GO:0071816 tail-anchored membrane protein insertion into ER membrane IMP 20676083
genes like me logo Genes that share ontologies with UBL4A: view

Transcripts for UBL4A Gene

Unigene Clusters for UBL4A Gene

Ubiquitin-like 4A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBL4A Gene

No ASD Table

Relevant External Links for UBL4A Gene

GeneLoc Exon Structure for
UBL4A
ECgene alternative splicing isoforms for
UBL4A

Expression for UBL4A Gene

mRNA expression in normal human tissues for UBL4A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBL4A Gene

SOURCE GeneReport for Unigene cluster for UBL4A Gene Hs.76480

genes like me logo Genes that share expressions with UBL4A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBL4A Gene

Orthologs for UBL4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBL4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBL4A 35
  • 100 (n)
  • 100 (a)
UBL4A 36
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 69 (a)
OneToMany
UBL4A 35
  • 84.93 (n)
  • 86.62 (a)
UBL4A 36
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia UBL4A 35
  • 88.96 (n)
  • 89.17 (a)
UBL4A 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc10a3-ubl4 35
  • 85.56 (n)
  • 89.81 (a)
Ubl4 16
Ubl4 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBL4A 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBL4A 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubl4a 35
  • 84.93 (n)
  • 88.54 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ubl4a 35
  • 57.31 (n)
  • 59.59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8734 35
zebrafish
(Danio rerio)
Actinopterygii UBL4A 36
  • 62 (a)
OneToMany
zgc:56596 35
  • 57.79 (n)
  • 63.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7215 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDY2 38
Species with no ortholog for UBL4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBL4A Gene

ENSEMBL:
Gene Tree for UBL4A (if available)
TreeFam:
Gene Tree for UBL4A (if available)

Paralogs for UBL4A Gene

Paralogs for UBL4A Gene

Selected SIMAP similar genes for UBL4A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with UBL4A: view

Variants for UBL4A Gene

Sequence variations from dbSNP and Humsavar for UBL4A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs11689 -- 154,484,040(+) GCCTA(A/G)CTAAT utr-variant-3-prime
rs1050047 -- 154,485,112(-) AGGCC(A/G)AGTGA utr-variant-3-prime
rs1063451 -- 154,484,549(-) CATGG(A/G/T)CTGGG utr-variant-3-prime
rs3174486 -- 154,484,758(-) CTTGT(C/T)TCGTC utr-variant-3-prime
rs3179869 -- 154,483,719(-) GGTCA(A/G)AACTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBL4A Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv33784 CNV Gain+Loss 17666407
nsv519042 CNV Gain 19592680

Relevant External Links for UBL4A Gene

HapMap Linkage Disequilibrium report
UBL4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBL4A Gene

Disorders for UBL4A Gene

No disorders were found for UBL4A Gene.

No data available for UniProtKB/Swiss-Prot for UBL4A Gene

Publications for UBL4A Gene

  1. A 'housekeeping' gene on the X chromosome encodes a protein similar to ubiquitin. (PMID: 2829204) Toniolo D. … Alcalay M. (Proc. Natl. Acad. Sci. U.S.A. 1988) 2 3 4
  2. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PMID: 8733135) Chen E.Y. … D'Urso M. (Hum. Mol. Genet. 1996) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Ubl4b, an X-derived retrogene, is specifically expressed in post-meiotic germ cells in mammals. (PMID: 16872915) Yang F. … Wang P.J. (Gene Expr. Patterns 2007) 2 3
  5. A ribosome-associating factor chaperones tail-anchored membrane proteins. (PMID: 20676083) Mariappan M. … Hegde R.S. (Nature 2010) 3 4

Products for UBL4A Gene

Sources for UBL4A Gene

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