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UBL3 Gene

protein-coding   GIFtS: 54

GC13M029236
ubiquitin-like 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PNSC1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZP434K151 1
DKFZp434K151 2
FLJ32018 1, 2
HCG-1 1, 2
HsMUB 3
MUB 3
PNSC1 2, 3
Descriptions
Membrane-anchored ubiquitin-fold protein 3
Protein HCG-1 3
ubiquitin-like 3 2
External Ids
HGNC: 125041
Entrez Gene: 54122
UniProtKB: O951643
Ensembl: ENSG000001220427
Search outside databases for aliases for UBL3 gene

Previous GC identifers: GC13M028318 GC13M024318 GC13M029268 GC13M028136

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for UBL3
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the UBL3 gene  

Entrez Gene cytogenetic band: 13q12-q13   Ensembl cytogenetic band:  13q12.3   HGNC cytogenetic band: 13q12-q13

UBL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M029236:     (about GC identifiers)

Start:
29,236,542 bp from pter
End:
29,322,715 bp from pter
Size:
86,174 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000013.9  NT_024524.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBL3_HUMAN, O95164 (See protein sequence)
Recommended Name: Ubiquitin-like protein 3 precursor  
Size: 117 amino acids; 13157 Da
Subcellular location: Cell membrane; Lipid-anchor (By similarity)
PDB structures from and Proteopedia :
2GOW (3D)    
Secondary accessions: Q5RL72 Q5VZS0 Q6FIG8 Q96SG7

REFSEQ proteins: NP_009037.1  

ENSEMBL proteins: 
ENSP00000370055 ENSP00000382442 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (UBL3)
Human Recombinant Proteins from Abnova (UBL3)
              OriGene Purified Recombinant Human Protein: UBL3 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IDA11256614
GO:0005886 plasma membrane IEA--
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Antibodies for UBL3: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for UBL3
Browse R&D Systems for Antibodies
Antibodies from Abcam (UBL3), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (UBL3)
Novus Biologicals Antibody for UBL3

Assays for UBL3: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro domains/families:
 IPR019954 Ubiquitin_CS
 IPR019955 Ubiquitin_supergroup
 IPR017000 M-anchored_Ub-fold_HCG-1


   GeneDecks  UBL3 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry O95164

ProtoNet protein and cluster: O95164

1 Blocks protein family: IPB000626 Ubiquitin domain

UniProtKB/Swiss-Prot: UBL3_HUMAN, O95164
Similarity: Contains 1 ubiquitin-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (UBL3)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (UBL3)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007106

              Applied Biosystems Silencer® siRNAs for UBL3

              Sigma-Aldrich siRNA and siRNA Panels for UBL3  
                     Sigma-Aldrich shRNA for UBL3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for UBL3
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007106
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_007106
                                 untagged cDNA clone in CMV expression vector: NM_007106 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_007106

Genatlas biochemistry entry for UBL3:
ubiquitin-like protein 3, Drosophila homolog,highly conserved in man and C elegans
(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006464 protein modification process IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBL3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (UBL3)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (UBL3)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007106

              Sigma-Aldrich siRNA and siRNA Panels for UBL3  
                     Sigma-Aldrich shRNA for UBL3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_007106  

REFSEQ mRNAs for UBL3 gene: 

NM_007106.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_007106  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007106
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_007106
                                 untagged cDNA clone in CMV expression vector: NM_007106 

Additional cDNA sequence: 

AF044221.1 AK056580.1 AK307361.1 AK309253.1 AK311846.1 AL080177.1 BC044582.1 BC059385.1 
CR533458.1 CR616220.1 

13 DOTS entries:

DT.445834  DT.100681183  DT.100783450  DT.95352397  DT.120777901  DT.99951603  DT.99949567  DT.120777923 
DT.120778009  DT.91769155  DT.95352395  DT.95356482  DT.91739663 

24/307 AceView cDNA sequences (see all 307 ):

AA376753 N20041 BM683532 BM721598 BU683096 CA312862 CR616220 CA389150 
BM980660 AI342281 BM667282 BX109420 AA490497 BM678533 AI252639 BQ215497 
BM974929 BX507395 AI598045 CA397679 T35676 BM129174 BM782563 AI953948 

highest scoring ESTs for UBL3:

AL080177 AA081968 AA149707 AA346700 AA376139 AF044221 AK056580 AU099162 AV724319 AW026070 

Unigene Cluster for UBL3:

Ubiquitin-like 3
Hs.145575  [show with all ESTs]
Unigene Representative Sequence: NM_007106


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000380680  ENST00000399526  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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UBL3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for UBL3

1 / 2 / 3

5 probe-sets matching UBL3 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
40839_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AL080177 1.00 1.00 1.00 1

201534_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF044221 0.80 1.00 0.91 1

201535_at2, 3 U133-A 1 1.00 1.00 -- -- NM_007106 0.60 1.00 0.82 1

201534_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

201535_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  UBL3 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GAAAAATACA

SOURCE GeneReport for Unigene cluster: Hs.145575

Expression variation in blood from EXPOLDB for UBL3

UniProtKB/Swiss-Prot: UBL3_HUMAN, O95164
Tissue specificity: Ubiquitous

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for UBL3 gene from 5/12 species (see all 12 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
UBL31   -- ubiquitin-like 3 97.72(n)
100(a)
607436  XM_844415.1  XP_849508.1 
chimpanzee
(Pan troglodytes)
UBL31   -- ubiquitin-like 3 100(n)
100(a)
736889  XM_001139173.1  XP_001139173.1 
cow
(Bos taurus)
UBL31   -- ubiquitin-like 3 93.16(n)
100(a)
526950  NM_001038144.1  NP_001033233.1 
rat
(Rattus norvegicus)
Ubl31   -- ubiquitin-like 3 87.46(n)
99.15(a)
363869  NM_001015030.1  NP_001015030.1 
mouse
(Mus musculus)
Ubl31, 5 55
ubiquitin-like 31, 5 88.32(n)1
99.15(a)1
241091  NM_011908.21  NP_036038.11 
 AF0442225  AF0442235  (see all 21)
About this table        Species with no ortholog for UBL3

ENSEMBL Gene Tree for UBL3
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/528 NCBI SNPs in UBL3 are shown (see all 528 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 167)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 13 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs2780371,2
A,C,F,H,O29322627(-) TGAGAG/AGAAAC 1 -- ut51 ese311Minor allele frequency- A:0.17NA EA MN EU WA 2316
rs10586501,2
A,C,F,H29238585(-) TGTGCA/GGAAAT 1 -- ut31 ese314Minor allele frequency- G:0.34NA MN EA EU WA 2242
rs43859891,2
C,F,H29239030(+) TTTTAG/ATGCAA 1 -- ut31 ese312Minor allele frequency- A:0.07EU EA WA NS NA 666
rs93149761,2
C,F,H29236359(+) GCATAT/CTAAAT 1 -- ng5116Minor allele frequency- C:0.12EU EA WA NS NA 1074
rs47697731,2
C,F,H29238094(+) GTTCTA/GTATAC 1 -- ut31 ese37Minor allele frequency- G:0.03EU EA WA NA 560
rs104924581,2
C,F,H29237472(+) ATTCAC/TATTTC 1 -- ut3116Minor allele frequency- T:0.09NS EU EA WA NA 1086
--
rs22344131,2
A,C29322530(-) GGGGAC/GGGGAA 1 -- ut51 ese3 trp30--------
rs79860221,2
F,H29237459(+) CAACAC/GTAACA 1 -- ut314Minor allele frequency- G:0.01EU EA WA 418
rs118394271,2
A,C29322658(+) CTCCTC/TCACTT 1 -- ut51 trp30--------
--
rs170738491,2
F29237348(+) GAGTAA/TTCAGA 1 -- ut31 ese33Minor allele frequency- T:0.01NA 142
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HapMap Linkage Disequilibrium images for UBL3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604711

1 PharmGKB disease relationship for UBL3 gene
Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
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(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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10/13 PubMed articles for UBL3 gene (see all 13 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5412 HGNC: 12504 AceView: UBL3 Ensembl:ENSG00000122042 euGenes: HUgn5412
ECgene: UBL3 H-InvDB: UBL3
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for UBL3:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for UBL3-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for UBL3 Antibodies for UBL3
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for UBL3 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Recombinant Proteins
(UBL3)
 Antibodies (UBL3)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for UBL3




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for UBL3

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