UBL3 Gene

Aliases
for UBL3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC13M028318 GC13M024318 GC13M029268 GC13M028136 GC13M029236 GC13M011152

Summaries
for UBL3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for UBL3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000013.10  NC_018924.2  NT_024524.15  

SwitchGear Promoter luciferase reporter plasmid: UBL3 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBL3

UBL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M030338:  view genomic region     (about GC identifiers)

Proteins
for UBL3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for UBL3:

2GOW (3D)    

Explore the universe of human proteins at neXtProt for UBL3: NX_O95164

Explore proteomics data for UBL3 at MOPED

Post-translational modifications: 

UBL3 Human Recombinant Protein Products:

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	antibodies-online peptides for UBL3

UBL3 Antibody Products:

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UBL3 Assay Products:

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	antibodies-online kits for UBL3 (8 products)

Domains /
Families
for UBL3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: O95164

Find genes that share domains with UBL3           About GenesLikeMe

Function
for UBL3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for UBL3

miRNA Products:		miRTarBase miRNAs that target UBL3: hsa-mir-215-5p (MIRT024892), hsa-mir-26b-5p (MIRT029836), hsa-mir-30a-5p (MIRT028556), hsa-mir-186-5p (MIRT045013), hsa-mir-192-5p (MIRT026728)
		Block miRNA regulation of human, mouse, rat UBL3 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate UBL3 (see all 84):
		hsa-miR-3678-3p hsa-miR-579 hsa-miR-607 hsa-miR-520f hsa-miR-300 hsa-miR-4272 hsa-miR-15a hsa-miR-298
		SwitchGear 3'UTR luciferase reporter plasmid: UBL3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for UBL3
		Predesigned siRNA for gene silencing in human, mouse, rat UBL3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for UBL3

Clone Products:		OriGene clones in human, mouse for UBL3 (see all 7) OriGene ORF clones in mouse, rat for UBL3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Sino Biological Human cDNA Clone for UBL3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBL3
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		Addgene plasmids for UBL3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for UBL3
		Browse ESI BIO Cell Lines and PureStem Progenitors for UBL3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL3

Localization
for UBL3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5
cytosol	3
nucleus	2
endoplasmic reticulum	1
extracellular	1
mitochondrion	1
peroxisome	1

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for UBL3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for UBL3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for UBL3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for UBL3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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UBL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAAAAATACA

About this image

Brain (Nervous System)
Cerebral Cortex
Placenta (Extraembryonic Tissues)
Stomach (Gastrointestinal Tract)

Primer Products:		OriGene qPCR primer pairs and template standards for UBL3 OriGene qSTAR qPCR primer pairs in human, mouse for UBL3
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		QuantiFast Probe-based Assays in human, mouse, rat UBL3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL3

Orthologs
for UBL3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for UBL3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for UBL3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for UBL3 (see all 1688)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs766750261,2	F	--	30338152(+)	CACAAA/TAACTG	1	--	int1		1		WA	118
rs1456528631,2		--	30338267(+)	CTCCAC/TTTGGC	1	--	int1		0	--	--	--	--
rs1878933331,2		--	30338276(+)	GCTAAC/TAAGTG	1	--	int1		0	--	--	--	--
rs1925246141,2		--	30338323(+)	ATGCTC/TGAAAA	1	--	int1		0	--	--	--	--
rs1833440121,2		--	30338344(+)	AAAAAC/TGGTAT	1	--	int1		0	--	--	--	--
rs93149761,2	C,F,H	--	30338359(+)	GCATAT/CTAAAT	1	--	int1		30		NS NA EA WA	3000
rs1178479111,2	F	--	30338684(+)	TTAACG/ATGAAT	1	--	ut31		2		NA EA	240
rs1487582231,2		--	30338813(+)	CAGAAC/TACTTA	1	--	ut31		0	--	--	--	--
rs1872572041,2		--	30338832(+)	CAGGAC/GAATTT	1	--	ut31		0	--	--	--	--
rs1116549991,2	C	--	30338938(+)	TTTAGA/GTAAGT	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for UBL3 (30338508 - 30424821 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for UBL3:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv1537429	CNV	Deletion	17803354
nsv899961	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing UBL3

DNA2.0 Custom Variant and Variant Library Synthesis for UBL3

Disorders / Diseases
for UBL3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for UBL3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene. (PubMed id 10375635)^{1, 2, 3} Chadwick B.P.... Frischauf A.-M. (Gene 1999)
2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
3. Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. (PubMed id 20460270)^{1, 4} Garcia-BarcelA^ M.M....Tam P.K. (Hum. Mol. Genet. 2010)
4. MUBS: a family of ubiquitin-fold proteins that are plasma membrane- anchored by prenylation. (PubMed id 16831869)^{1, 2} Downes B.P.... Vierstra R.D. (J. Biol. Chem. 2006)
5. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (Nature 2004)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (Genome Res. 2001)
9. A genome-wide association study for reading and language abilities in two population cohorts. (PubMed id 23738518)¹ Luciano M....Bates T.C. (Genes Brain Behav. 2013)
10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

External Searches for UBL3 gene

Genome Databases showing UBL3 gene

Other Databases showing UBL3 gene

Specialized Databases showing UBL3 gene

Products
for UBL3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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