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Aliases for UBL3 Gene

Aliases for UBL3 Gene

  • Ubiquitin Like 3 2 3 5
  • Membrane-Anchored Ubiquitin-Fold Protein 3 4
  • Protein HCG-1 3 4
  • HsMUB 3 4
  • PNSC1 3 4
  • MUB 3 4
  • Ubiquitin-Like Protein 3 3
  • Ubiquitin-Like 3 2
  • HCG-1 3

External Ids for UBL3 Gene

Previous HGNC Symbols for UBL3 Gene

  • PNSC1

Previous GeneCards Identifiers for UBL3 Gene

  • GC13M028318
  • GC13M024318
  • GC13M029268
  • GC13M028136
  • GC13M029236
  • GC13M030338
  • GC13M011152

Summaries for UBL3 Gene

GeneCards Summary for UBL3 Gene

UBL3 (Ubiquitin Like 3) is a Protein Coding gene.

Gene Wiki entry for UBL3 Gene

Additional gene information for UBL3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBL3 Gene

Genomics for UBL3 Gene

Regulatory Elements for UBL3 Gene

Enhancers for UBL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H030112 1.5 Ensembl ENCODE dbSUPER 11.1 -263.5 -263494 3.2 ARID4B SIN3A ZNF2 YY1 ELK1 ZNF143 ZNF207 RUNX3 REST ZNF592 UBL3 HMGB1 LINC00365 PIR52167 GC13M030142
GH13H030107 1.4 Ensembl ENCODE dbSUPER 11.1 -258.4 -258371 4.1 FOXA2 PKNOX1 NFIB SIN3A KLF17 RAD21 YY1 SCRT2 FOS CEBPB UBL3 LINC00365 GC13M030142 PIR52167
GH13H029922 1.4 Ensembl ENCODE 10.5 -73.8 -73846 4.7 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 LINC01058 USPL1 UBL3 LINC00572 LINC00297
GH13H030002 0.9 Ensembl ENCODE 15.5 -152.1 -152088 0.5 SMARCE1 PKNOX1 JUNB MNT BATF FOXA1 JUND GATA3 CTBP1 IKZF1 UBL3 LINC00544 ENSG00000266505
GH13H030462 1.3 ENCODE dbSUPER 9.5 -614.1 -614139 5.3 HDGF FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 HMGB1 USPL1 KATNAL1 UBL3 GC13M030460 MFAP1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBL3 on UCSC Golden Path with GeneCards custom track

Promoters for UBL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000060549 1884 4001 HDGF ATF1 ARID4B SIN3A FEZF1 GLI4 ZNF2 ZBTB7B YY1 ETS1

Genomic Locations for UBL3 Gene

Genomic Locations for UBL3 Gene
86,314 bases
Minus strand

Genomic View for UBL3 Gene

Genes around UBL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL3 Gene

Proteins for UBL3 Gene

  • Protein details for UBL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-like protein 3
    Protein Accession:
    Secondary Accessions:
    • B2R4J1
    • Q5RL72
    • Q5VZS0
    • Q6FIG8
    • Q96SG7

    Protein attributes for UBL3 Gene

    117 amino acids
    Molecular mass:
    13157 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBL3 Gene

neXtProt entry for UBL3 Gene

Post-translational modifications for UBL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBL3 Gene

Domains & Families for UBL3 Gene

Gene Families for UBL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBL3 Gene

Suggested Antigen Peptide Sequences for UBL3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBL3: view

No data available for UniProtKB/Swiss-Prot for UBL3 Gene

Function for UBL3 Gene

Molecular function for UBL3 Gene

GENATLAS Biochemistry:
ubiquitin-like protein 3, Drosophila homolog,highly conserved in man and C elegans

Phenotypes From GWAS Catalog for UBL3 Gene

genes like me logo Genes that share phenotypes with UBL3: view

Clone Products

  • Addgene plasmids for UBL3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBL3 Gene

Localization for UBL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBL3 Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBL3 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 3
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UBL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with UBL3: view

Pathways & Interactions for UBL3 Gene

No Data Available

Interacting Proteins for UBL3 Gene

Selected Interacting proteins: O95164-UBL3_HUMAN for UBL3 Gene via IID

Gene Ontology (GO) - Biological Process for UBL3 Gene


No data available for Pathways by source and SIGNOR curated interactions for UBL3 Gene

Drugs & Compounds for UBL3 Gene

No Compound Related Data Available

Transcripts for UBL3 Gene

mRNA/cDNA for UBL3 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(307) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UBL3 Gene

Ubiquitin-like 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for UBL3

Alternative Splicing Database (ASD) splice patterns (SP) for UBL3 Gene

No ASD Table

Relevant External Links for UBL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBL3 Gene

This gene is overexpressed in Cervix (43.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBL3 Gene:


SOURCE GeneReport for Unigene cluster for UBL3 Gene:


mRNA Expression by UniProt/SwissProt for UBL3 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for UBL3 Gene

  • Nervous system(4.9)
  • Skin(2.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with UBL3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBL3 Gene

Orthologs for UBL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBL3 33 34
  • 100 (n)
(Monodelphis domestica)
Mammalia UBL3 34
  • 99 (a)
(Canis familiaris)
Mammalia UBL3 33 34
  • 97.72 (n)
(Ornithorhynchus anatinus)
Mammalia UBL3 34
  • 94 (a)
(Bos Taurus)
Mammalia UBL3 33 34
  • 93.16 (n)
(Mus musculus)
Mammalia Ubl3 33 16 34
  • 88.32 (n)
(Rattus norvegicus)
Mammalia Ubl3 33
  • 87.46 (n)
(Gallus gallus)
Aves UBL3 33 34
  • 86.89 (n)
(Anolis carolinensis)
Reptilia UBL3 34
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubl3 33
  • 84.62 (n)
Str.5748 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.21417 33
(Danio rerio)
Actinopterygii ubl3a 33 34
  • 79.2 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013294 33
  • 64.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta UBL3 35 33 34
  • 63.74 (n)
(Caenorhabditis elegans)
Secernentea C46F11.6 33 34
  • 55.15 (n)
Species where no ortholog for UBL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBL3 Gene

Gene Tree for UBL3 (if available)
Gene Tree for UBL3 (if available)

Paralogs for UBL3 Gene

No data available for Paralogs for UBL3 Gene

Variants for UBL3 Gene

Sequence variations from dbSNP and Humsavar for UBL3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000017030 -- 29,849,358(+) TAAAA(C/G)GGGGA intron-variant
rs1000059176 -- 29,807,895(+) TTCCT(C/T)CATTT intron-variant
rs1000061417 -- 29,786,776(+) ATGAT(A/G)TAGAT intron-variant
rs1000078232 -- 29,816,412(+) GTGCT(A/G)AAGTA intron-variant
rs1000121705 -- 29,764,030(+) TAGAC(G/T)CCAGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for UBL3 Gene

Variant ID Type Subtype PubMed ID
esv1537429 CNV deletion 17803354

Variation tolerance for UBL3 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBL3 Gene

Disorders for UBL3 Gene

Relevant External Links for UBL3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBL3 Gene

Publications for UBL3 Gene

  1. Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene. (PMID: 10375635) Chadwick BP … Frischauf AM (Gene 1999) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. (PMID: 20460270) Garcia-Barceló MM … Tam PK (Human molecular genetics 2010) 3 45 60
  4. MUBs, a family of ubiquitin-fold proteins that are plasma membrane-anchored by prenylation. (PMID: 16831869) Downes BP … Vierstra RD (The Journal of biological chemistry 2006) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for UBL3 Gene

  • Addgene plasmids for UBL3

Sources for UBL3 Gene

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