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Aliases for UBL3 Gene

Aliases for UBL3 Gene

  • Ubiquitin Like 3 2 3 5
  • Membrane-Anchored Ubiquitin-Fold Protein 3 4
  • Protein HCG-1 3 4
  • HsMUB 3 4
  • PNSC1 3 4
  • MUB 3 4
  • Ubiquitin-Like Protein 3 3
  • Ubiquitin-Like 3 2
  • HCG-1 3

External Ids for UBL3 Gene

Previous HGNC Symbols for UBL3 Gene

  • PNSC1

Previous GeneCards Identifiers for UBL3 Gene

  • GC13M028318
  • GC13M024318
  • GC13M029268
  • GC13M028136
  • GC13M029236
  • GC13M030338
  • GC13M011152

Summaries for UBL3 Gene

GeneCards Summary for UBL3 Gene

UBL3 (Ubiquitin Like 3) is a Protein Coding gene.

Gene Wiki entry for UBL3 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBL3 Gene

Genomics for UBL3 Gene

Regulatory Elements for UBL3 Gene

Enhancers for UBL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F029800 1 Ensembl ENCODE 16.9 +49.0 49042 2.7 CTCF MTA2 CBFB TBX21 RAD21 SMARCA4 POLR2A IKZF1 EED ZNF143 UBL3 LOC105370139
GH13F030002 0.9 Ensembl ENCODE 15.5 -151.9 -151918 0.8 PKNOX1 JUN JUNB REST RAD21 GATA3 CTBP1 JUND IKZF1 FOS UBL3 LINC00544 ENSG00000266505
GH13F029953 0.9 Ensembl ENCODE 15.2 -103.6 -103618 1.4 MTA2 CEBPB CEBPG RAD21 YY1 CTBP1 ATF3 CEBPA EED ETV6 UBL3 LINC00572 LINC00544 ENSG00000266505
GH13F029922 1.3 Ensembl ENCODE 10.5 -73.8 -73846 4.7 PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 UBL3 LINC00572 LINC00297
GH13F030112 1.2 Ensembl ENCODE 11.1 -263.5 -263517 3.2 WRNIP1 ARID4B SIN3A ZNF2 YY1 ELK1 ZNF143 ZNF207 REST MAFF UBL3 HMGB1 LINC00365 GC13M030142 PIR52167
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBL3 Gene

Chromosome:
13
Start:
29,764,371 bp from pter
End:
29,850,684 bp from pter
Size:
86,314 bases
Orientation:
Minus strand

Genomic View for UBL3 Gene

Genes around UBL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBL3 Gene

Proteins for UBL3 Gene

  • Protein details for UBL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95164-UBL3_HUMAN
    Recommended name:
    Ubiquitin-like protein 3
    Protein Accession:
    O95164
    Secondary Accessions:
    • B2R4J1
    • Q5RL72
    • Q5VZS0
    • Q6FIG8
    • Q96SG7

    Protein attributes for UBL3 Gene

    Size:
    117 amino acids
    Molecular mass:
    13157 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBL3 Gene

neXtProt entry for UBL3 Gene

Post-translational modifications for UBL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for UBL3
  • Santa Cruz Biotechnology (SCBT) Antibodies for UBL3

No data available for DME Specific Peptides for UBL3 Gene

Domains & Families for UBL3 Gene

Protein Domains for UBL3 Gene

Suggested Antigen Peptide Sequences for UBL3 Gene

Graphical View of Domain Structure for InterPro Entry

O95164

UniProtKB/Swiss-Prot:

UBL3_HUMAN :
  • Contains 1 ubiquitin-like domain.
Domain:
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with UBL3: view

No data available for Gene Families for UBL3 Gene

Function for UBL3 Gene

Molecular function for UBL3 Gene

GENATLAS Biochemistry:
ubiquitin-like protein 3, Drosophila homolog,highly conserved in man and C elegans
genes like me logo Genes that share phenotypes with UBL3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBL3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBL3 Gene

Localization for UBL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBL3 Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBL3 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 3
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for UBL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with UBL3: view

Pathways & Interactions for UBL3 Gene

No Data Available

Interacting Proteins for UBL3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000370055%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000370055 O95164-UBL3_HUMAN for UBL3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for UBL3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBL3 Gene

Transcripts for UBL3 Gene

mRNA/cDNA for UBL3 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(307) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UBL3 Gene

Ubiquitin-like 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBL3 Gene

No ASD Table

Relevant External Links for UBL3 Gene

GeneLoc Exon Structure for
UBL3
ECgene alternative splicing isoforms for
UBL3

Expression for UBL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBL3 Gene

This gene is overexpressed in Cervix (43.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBL3 Gene



NURSA nuclear receptor signaling pathways regulating expression of UBL3 Gene:

UBL3

SOURCE GeneReport for Unigene cluster for UBL3 Gene:

Hs.145575

mRNA Expression by UniProt/SwissProt for UBL3 Gene:

O95164-UBL3_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with UBL3: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for UBL3 Gene

Orthologs for UBL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBL3 34 35
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia UBL3 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBL3 34 35
  • 97.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBL3 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBL3 34 35
  • 93.16 (n)
mouse
(Mus musculus)
Mammalia Ubl3 34 16 35
  • 88.32 (n)
rat
(Rattus norvegicus)
Mammalia Ubl3 34
  • 87.46 (n)
chicken
(Gallus gallus)
Aves UBL3 34 35
  • 86.89 (n)
lizard
(Anolis carolinensis)
Reptilia UBL3 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubl3 34
  • 84.62 (n)
Str.5748 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.21417 34
zebrafish
(Danio rerio)
Actinopterygii ubl3a 34 35
  • 79.2 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013294 34
  • 64.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta UBL3 36 34 35
  • 63.74 (n)
worm
(Caenorhabditis elegans)
Secernentea C46F11.6 34 35
  • 55.15 (n)
Species where no ortholog for UBL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBL3 Gene

ENSEMBL:
Gene Tree for UBL3 (if available)
TreeFam:
Gene Tree for UBL3 (if available)

Paralogs for UBL3 Gene

No data available for Paralogs for UBL3 Gene

Variants for UBL3 Gene

Sequence variations from dbSNP and Humsavar for UBL3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10492458 -- 29,765,335(+) ATTCA(C/T)ATTTC utr-variant-3-prime
rs10531958 -- 29,841,261(+) GAGAA(-/TCTC)TCTCT intron-variant
rs10577289 -- 29,786,895(+) AGGTC(-/AG)AGAGT intron-variant
rs1058647 -- 29,849,586(-) TTTTT(C/T)TTTGT utr-variant-5-prime
rs1058650 -- 29,766,448(-) TGTGC(A/G)GAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBL3 Gene

Variant ID Type Subtype PubMed ID
esv1537429 CNV deletion 17803354

Variation tolerance for UBL3 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBL3 Gene

Disorders for UBL3 Gene

Relevant External Links for UBL3

Genetic Association Database (GAD)
UBL3
Human Genome Epidemiology (HuGE) Navigator
UBL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBL3

No disorders were found for UBL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBL3 Gene

Publications for UBL3 Gene

  1. Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene. (PMID: 10375635) Chadwick B.P. … Frischauf A.-M. (Gene 1999) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. (PMID: 20460270) Garcia-BarcelA^ M.M. … Tam P.K. (Hum. Mol. Genet. 2010) 3 46 64
  4. MUBS: a family of ubiquitin-fold proteins that are plasma membrane- anchored by prenylation. (PMID: 16831869) Downes B.P. … Vierstra R.D. (J. Biol. Chem. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for UBL3 Gene

Sources for UBL3 Gene

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