UBL3 Gene
protein-coding GIFtS: 49
GCID: GC13M030338
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ubiquitin-like 3
(Previous symbol: PNSC1)
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Aliases
for UBL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Like 31 2 | | DKFZP434K1511 | | PNSC11 2 3 | | FLJ320181 | | HCG-11 2 | | HsMUB3 | | Membrane-Anchored Ubiquitin-Fold Protein2 3 | | Ubiquitin-Like Protein 32 | | Protein HCG-12 3 | | HsMUB3 | | MUB2 3 | | |
Export aliases for UBL3 gene to outside databasesPrevious GC identifers: GC13M028318 GC13M024318 GC13M029268 GC13M028136 GC13M029236 GC13M011152 |
Summaries
for UBL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for UBL3
|
Genomic Views
for UBL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBL3 gene promoter:
HOXA3 AML1a MyoD AP-4 IRF-1 CUTL1 AP-2gamma LCR-F1 Egr-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBL3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q12-q13 Ensembl cytogenetic band: 13q12.3 HGNC cytogenetic band: 13q12-q13UBL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M030338: view genomic region
(about GC identifiers)
Start:
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30,338,508 bp from pter |
End:
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30,424,821 bp from pter |
Size:
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86,314 bases |
Orientation:
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minus strand |
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Proteins
for UBL3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBL3_HUMAN, O95164 (See
protein sequence)Recommended Name: Ubiquitin-like protein 3 precursor Size: 117 amino acids; 13157 Da
Subcellular location: Cell membrane; Lipid-anchor (By similarity)
1 PDB 3D structure from  and Proteopedia  for UBL3:2GOW (3D)
Secondary accessions: B2R4J1 Q5RL72 Q5VZS0 Q6FIG8 Q96SG7Explore the universe of human proteins at neXtProt for UBL3: NX_O95164
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95164
UBL3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009037.1
ENSEMBL proteins: ENSP00000370055
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IDA | -- | | GO:0005886 | plasma membrane |
IEA | -- |
UBL3 for ontologies About GeneDecksing
UBL3 Antibody Products:
Assay Products for UBL3: |
Protein
Domains /
Families
for UBL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBL3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95164ProtoNet protein and cluster: O95164 1 Blocks protein family: IPB000626 Ubiquitin domain
UniProtKB/Swiss-Prot: UBL3_HUMAN, O95164Similarity: Contains 1 ubiquitin-like domain |
Function
for UBL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for UBL3:ubiquitin-like protein 3, Drosophila homolog,highly conserved in man and C elegans
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBL3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBL3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for UBL3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBL3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL3 |
1 GenomeRNAi human phenotype for UBL3:
|
Pathways & Interactions
for UBL3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBL3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for UBL3 (ENSP000003700554) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for UBL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBL3
Search CenterWatch for drugs/clinical trials and news about UBL3
|
Transcripts
for UBL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBL3 gene: NM_007106.3 Unigene Cluster for UBL3: Ubiquitin-like 3 Hs.145575 [show with all ESTs]Unigene Representative Sequence: NM_0071061 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000380680(uc001usp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBL3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBL3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBL3 (NM_007106) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBL3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBL3 |
Additional cDNA sequence: AF044221.1 AK056580.1 AK307361.1 AK309253.1 AK311846.1 AL080177.1 BC044582.1 BC059385.1 CR533458.1 14 DOTS entries: DT.445834 DT.100681183 DT.95352397 DT.100783450 DT.120777901 DT.99951603 DT.99949567 DT.120777923 DT.120778009 DT.91769155 DT.95352395 DT.95356482 DT.91739663 DT.91920372 24/307 AceView cDNA sequences (see all 307): CA389150 AA970077 AA376753 BQ024888 AI307685 BM996258 CA312862 AI754090 BX109420 AA490497 AA508749 CA395639 T35676 N42557 BQ023207 AI598045 BM129157 H20839 BM980660 AK056580 AA412190 AI568179 BM683532 AA811460
GeneLoc Exon Structure
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Expression
for UBL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAAATACA
About this image
See UBL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBL3
SOURCE GeneReport for Unigene cluster: Hs.145575
UniProtKB/Swiss-Prot: UBL3_HUMAN, O95164Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for UBL3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBL3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBL3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL3 |
Orthologs
for UBL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for UBL3 gene from 7/18 species (see all 18) About this table
ENSEMBL Gene Tree for UBL3 (if available)
TreeFam Gene Tree for UBL3 (if available) |
Paralogs
for UBL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for UBL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBL3 (30338508 - 30424821 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBL3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBL3 |
|
Disorders
/ Diseases
for UBL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBL3 for disorders About GeneDecksing
OMIM gene information: 604711
OMIM disorders: --
3  diseases for UBL3: About MalaCardsalcohol abuse biliary atresia alcoholism
Human Genome Epidemiology (HuGE) Navigator: UBL3 (1 document)
Export disorders for UBL3 gene to outside databases
|
Publications
for UBL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBL3 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with UBL3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene. (PubMed id 10375635)1, 2, 3 Chadwick B.P.... Frischauf A.-M. (1999)
- MUBS: a family of ubiquitin-fold proteins that are plasma membrane- anchored by prenylation. (PubMed id 16831869)1, 2 Downes B.P.... Vierstra R.D. (2006)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genome-wide association study identifies a susceptibi lity locus for biliary atresia on 10q24.2. (PubMed id 20460270)1 Garcia-BarcelA^ M.M....Tam P.K. (2010)
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External Searches for UBL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing UBL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBL3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBL3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for UBL3 gene:
Search GeneIP for patents involving UBL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UBL3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBL3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBL3 | | | OriGene Protein Over-expression Lysate for UBL3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBL3 | | OriGene 3'-UTR Clone for UBL3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBL3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBL3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for UBL3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UBL3 | | OriGene Custom Protein Services for UBL3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBL3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBL3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBL3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBL3 |
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| |  |  |  |  | | | | | | Recombinant Protein for UBL3 |
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 | | | UBL3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBL3 |
|  |  |  | | | | Search ThermoFisher Antibodies for UBL3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBL3 |
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