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Aliases for UBFD1 Gene

Aliases for UBFD1 Gene

  • Ubiquitin Family Domain Containing 1 2 3
  • Ubiquitin-Binding Protein Homolog 2 3 4
  • UBPH 3 4
  • Ubiquitin Domain-Containing Protein UBFD1 3

External Ids for UBFD1 Gene

Summaries for UBFD1 Gene

GeneCards Summary for UBFD1 Gene

UBFD1 (Ubiquitin Family Domain Containing 1) is a Protein Coding gene. Diseases associated with UBFD1 include paget disease of bone.

UniProtKB/Swiss-Prot for UBFD1 Gene

  • May play a role as NF-kappa-B regulator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBFD1 Gene

Genomics for UBFD1 Gene

Genomic Location for UBFD1 Gene

Start:
23,557,362 bp from pter
End:
23,574,394 bp from pter
Size:
17,033 bases
Orientation:
Plus strand

Genomic View for UBFD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBFD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBFD1 Gene

Regulatory Elements for UBFD1 Gene

Proteins for UBFD1 Gene

  • Protein details for UBFD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14562-UBFD1_HUMAN
    Recommended name:
    Ubiquitin domain-containing protein UBFD1
    Protein Accession:
    O14562
    Secondary Accessions:
    • A8MW58
    • D3DWF2

    Protein attributes for UBFD1 Gene

    Size:
    309 amino acids
    Molecular mass:
    33382 Da
    Quaternary structure:
    • Binds polyubiquitin
    SequenceCaution:
    • Sequence=AAC05812.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW55818.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW55819.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for UBFD1 Gene

Proteomics data for UBFD1 Gene at MOPED

Post-translational modifications for UBFD1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys100, Lys111, Lys113, Lys126, Lys149, Lys167, Lys245, and Lys305

Other Protein References for UBFD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBFD1 Gene

Domains for UBFD1 Gene

Protein Domains for UBFD1 Gene

Graphical View of Domain Structure for InterPro Entry

O14562

UniProtKB/Swiss-Prot:

UBFD1_HUMAN
Domain:
  • Contains 1 ubiquitin-like domain.:
    • O14562
genes like me logo Genes that share domains with UBFD1: view

No data available for Gene Families for UBFD1 Gene

Function for UBFD1 Gene

Molecular function for UBFD1 Gene

UniProtKB/Swiss-Prot Function: May play a role as NF-kappa-B regulator.

Gene Ontology (GO) - Molecular Function for UBFD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with UBFD1: view

Phenotypes for UBFD1 Gene

GenomeRNAi human phenotypes for UBFD1:
genes like me logo Genes that share phenotypes with UBFD1: view

miRNA for UBFD1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBFD1 Gene

Localization for UBFD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBFD1 Gene COMPARTMENTS Subcellular localization image for UBFD1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBFD1 Gene

Pathways for UBFD1 Gene

SuperPathways for UBFD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBFD1 Gene

None

No data available for Pathways by source for UBFD1 Gene

Compounds for UBFD1 Gene

(1) Novoseek inferred chemical compound relationships for UBFD1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 0 1
genes like me logo Genes that share compounds with UBFD1: view

Transcripts for UBFD1 Gene

Unigene Clusters for UBFD1 Gene

Ubiquitin family domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBFD1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: -
SP3: -
SP4: - -
SP5:
SP6: - -

Relevant External Links for UBFD1 Gene

GeneLoc Exon Structure for
UBFD1
ECgene alternative splicing isoforms for
UBFD1

Expression for UBFD1 Gene

mRNA expression in normal human tissues for UBFD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBFD1 Gene

This gene is overexpressed in Muscle - Skeletal (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBFD1 Gene

SOURCE GeneReport for Unigene cluster for UBFD1 Gene Hs.3459

genes like me logo Genes that share expressions with UBFD1: view

No data available for mRNA Expression by UniProt/SwissProt for UBFD1 Gene

Orthologs for UBFD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBFD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBFD1 35
  • 99.11 (n)
  • 98.67 (a)
UBFD1 36
  • 57 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBFD1 35
  • 93.46 (n)
  • 98.04 (a)
UBFD1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBFD1 35
  • 93.42 (n)
  • 97.41 (a)
UBFD1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubfd1 35
  • 91.15 (n)
  • 96.76 (a)
Ubfd1 16
Ubfd1 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBFD1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBFD1 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubfd1 35
  • 91.26 (n)
  • 96.12 (a)
chicken
(Gallus gallus)
Aves UBFD1 35
  • 78.34 (n)
  • 82.31 (a)
UBFD1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBFD1 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11034 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3410 35
ubfd1 35
  • 74.97 (n)
  • 83.4 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10126 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17009 35
ubfd1 35
  • 75.48 (n)
  • 84.71 (a)
ubfd1 36
  • 75 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4216 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for UBFD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBFD1 Gene

ENSEMBL:
Gene Tree for UBFD1 (if available)
TreeFam:
Gene Tree for UBFD1 (if available)

Paralogs for UBFD1 Gene

Pseudogenes.org Pseudogenes for UBFD1 Gene

genes like me logo Genes that share paralogs with UBFD1: view

No data available for Paralogs for UBFD1 Gene

Variants for UBFD1 Gene

Sequence variations from dbSNP and Humsavar for UBFD1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1610 -- 23,570,832(-) TCCAT(C/T)GTATT utr-variant-3-prime, nc-transcript-variant
rs9871 -- 23,573,740(-) AAAAC(A/G)AGCCC utr-variant-3-prime, nc-transcript-variant
rs152454 -- 23,571,790(+) TTTCA(A/C/G/T)GATTA utr-variant-3-prime, nc-transcript-variant
rs152455 -- 23,571,752(+) GGCCA(A/C/G/T)TGTTA utr-variant-3-prime, nc-transcript-variant
rs152457 -- 23,570,357(-) AAAAC(C/T)TTGCA intron-variant

Relevant External Links for UBFD1 Gene

HapMap Linkage Disequilibrium report
UBFD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UBFD1 Gene

Disorders for UBFD1 Gene

(1) MalaCards Diseases for UBFD1 Gene

Search for UBFD1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for UBFD1 Gene

Disease -log(P) Hits PubMed IDs
neurodegenerative diseases 44.9 1
genes like me logo Genes that share disorders with UBFD1: view

No data available for UniProtKB/Swiss-Prot for UBFD1 Gene

Publications for UBFD1 Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification of polyubiquitin binding proteins involved in NF- kappaB signaling using protein arrays. (PMID: 19285159) Fenner B.J. … Prehn J.H. (Biochim. Biophys. Acta 2009) 3 4
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for UBFD1 Gene

Sources for UBFD1 Gene

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