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Aliases for UBFD1 Gene

Aliases for UBFD1 Gene

  • Ubiquitin Family Domain Containing 1 2 3 5
  • Ubiquitin-Binding Protein Homolog 2 3 4
  • UBPH 3 4

External Ids for UBFD1 Gene

Previous GeneCards Identifiers for UBFD1 Gene

  • GC16P023476
  • GC16P023568
  • GC16P021659

Summaries for UBFD1 Gene

GeneCards Summary for UBFD1 Gene

UBFD1 (Ubiquitin Family Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for UBFD1 Gene

  • May play a role as NF-kappa-B regulator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBFD1 Gene

Genomics for UBFD1 Gene

Regulatory Elements for UBFD1 Gene

Promoters for UBFD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBFD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBFD1 Gene

Chromosome:
16
Start:
23,557,362 bp from pter
End:
23,574,394 bp from pter
Size:
17,033 bases
Orientation:
Plus strand

Genomic View for UBFD1 Gene

Genes around UBFD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBFD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBFD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBFD1 Gene

Proteins for UBFD1 Gene

  • Protein details for UBFD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14562-UBFD1_HUMAN
    Recommended name:
    Ubiquitin domain-containing protein UBFD1
    Protein Accession:
    O14562
    Secondary Accessions:
    • A8MW58
    • D3DWF2

    Protein attributes for UBFD1 Gene

    Size:
    309 amino acids
    Molecular mass:
    33382 Da
    Quaternary structure:
    • Binds polyubiquitin.
    SequenceCaution:
    • Sequence=AAC05812.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW55818.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW55819.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for UBFD1 Gene

Proteomics data for UBFD1 Gene at MOPED

Post-translational modifications for UBFD1 Gene

  • Ubiquitination at Lys 100, Lys 111, Lys 113, Lys 126, Lys 149, Lys 167, Lys 245, and Lys 305
  • Modification sites at PhosphoSitePlus

Other Protein References for UBFD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for UBFD1

No data available for DME Specific Peptides for UBFD1 Gene

Domains & Families for UBFD1 Gene

Protein Domains for UBFD1 Gene

Graphical View of Domain Structure for InterPro Entry

O14562

UniProtKB/Swiss-Prot:

UBFD1_HUMAN :
  • Contains 1 ubiquitin-like domain.
Domain:
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with UBFD1: view

No data available for Gene Families for UBFD1 Gene

Function for UBFD1 Gene

Molecular function for UBFD1 Gene

UniProtKB/Swiss-Prot Function:
May play a role as NF-kappa-B regulator.
genes like me logo Genes that share phenotypes with UBFD1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBFD1 Gene

Localization for UBFD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBFD1 Gene COMPARTMENTS Subcellular localization image for UBFD1 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBFD1 Gene

Pathways & Interactions for UBFD1 Gene

SuperPathways for UBFD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBFD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBFD1 Gene

Drugs & Compounds for UBFD1 Gene

(1) Drugs for UBFD1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with UBFD1: view

Transcripts for UBFD1 Gene

Unigene Clusters for UBFD1 Gene

Ubiquitin family domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBFD1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: -
SP3: -
SP4: - -
SP5:
SP6: - -

Relevant External Links for UBFD1 Gene

GeneLoc Exon Structure for
UBFD1
ECgene alternative splicing isoforms for
UBFD1

Expression for UBFD1 Gene

mRNA expression in normal human tissues for UBFD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBFD1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.2).

Protein differential expression in normal tissues from HIPED for UBFD1 Gene

This gene is overexpressed in Skin (9.5) and Testis (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBFD1 Gene



SOURCE GeneReport for Unigene cluster for UBFD1 Gene Hs.3459

genes like me logo Genes that share expression patterns with UBFD1: view

Protein tissue co-expression partners for UBFD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UBFD1 Gene

Orthologs for UBFD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBFD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBFD1 35
  • 93.46 (n)
  • 98.04 (a)
UBFD1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBFD1 35
  • 93.42 (n)
  • 97.41 (a)
UBFD1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubfd1 35
  • 91.15 (n)
  • 96.76 (a)
Ubfd1 16
Ubfd1 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBFD1 35
  • 99.11 (n)
  • 98.67 (a)
UBFD1 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubfd1 35
  • 91.26 (n)
  • 96.12 (a)
oppossum
(Monodelphis domestica)
Mammalia UBFD1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBFD1 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBFD1 35
  • 78.34 (n)
  • 82.31 (a)
UBFD1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBFD1 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3410 35
ubfd1 35
  • 74.97 (n)
  • 83.4 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11034 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17009 35
ubfd1 35
  • 75.48 (n)
  • 84.71 (a)
ubfd1 36
  • 75 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10126 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4216 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for UBFD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBFD1 Gene

ENSEMBL:
Gene Tree for UBFD1 (if available)
TreeFam:
Gene Tree for UBFD1 (if available)

Paralogs for UBFD1 Gene

Pseudogenes.org Pseudogenes for UBFD1 Gene

genes like me logo Genes that share paralogs with UBFD1: view

No data available for Paralogs for UBFD1 Gene

Variants for UBFD1 Gene

Sequence variations from dbSNP and Humsavar for UBFD1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1610 -- 23,570,832(-) TCCAT(C/T)GTATT nc-transcript-variant, utr-variant-3-prime
rs9871 -- 23,573,740(-) AAAAC(A/G)AGCCC nc-transcript-variant, utr-variant-3-prime
rs152454 -- 23,571,790(+) TTTCA(A/C/G/T)GATTA nc-transcript-variant, utr-variant-3-prime
rs152455 -- 23,571,752(+) GGCCA(A/C/G/T)TGTTA nc-transcript-variant, utr-variant-3-prime
rs152457 -- 23,570,357(-) AAAAC(C/T)TTGCA intron-variant

Variation tolerance for UBFD1 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBFD1 Gene

HapMap Linkage Disequilibrium report
UBFD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UBFD1 Gene

Disorders for UBFD1 Gene

Relevant External Links for UBFD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBFD1

No disorders were found for UBFD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBFD1 Gene

Publications for UBFD1 Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates. (PMID: 24811749) Besche H.C. … Goldberg A.L. (EMBO J. 2014) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for UBFD1 Gene

Sources for UBFD1 Gene

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