UBE4B Gene
protein-coding GIFtS: 64
GCID: GC01P010092
|
|
ubiquitination factor E4B(Previous names: ubiquitination factor E4B (homologous to yeast UFD2), ubiquitination...)
| |
Aliases
for UBE4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitination Factor E4B1 2 | | Ubiquitin Fusion Degradation Protein 22 3 | | UFD21 2 3 | | HDNB12 3 | | KIAA06841 3 5 | | UFD2A2 5 | | E41 2 | | Homologous To Yeast UFD22 | | UBOX31 2 | | Homozygously Deleted In Neuroblastoma-12 | | Ubiquitination Factor E4B (Homologous To Yeast UFD2)1 2 | | Ubiquitin Conjugation Factor E4 B2 | | Ubiquitination Factor E4B (UFD2 Homolog, Yeast)1 2 | | Ubiquitin-Fusion Degradation Protein 22 | | Homozygously Deleted In Neuroblastoma 12 3 | | UFD2A-III/UBE4B-III Splice Isoform2 |
Export aliases for UBE4B gene to outside databasesPrevious GC identifers: GC01P010054 GC01P009937 GC01P009702 GC01P009803 GC01P009802 GC01P010027 GC01P009247 |
Summaries
for UBE4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBE4B:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, orE1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additionalconjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidatein the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms havebeen found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: UBE4B_HUMAN, O95155Function: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunctionwith E1, E2, and E3 (By similarity)
Gene Wiki entry for UBE4B
|
Genomic Views
for UBE4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE4B gene promoter:
MAZR Sp1 NF-kappaB E47 CREB FOXC1 NF-kappaB2 deltaCREB Hand1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE4B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE4B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.3 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.1UBE4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P010092: view genomic region
(about GC identifiers)
Start:
|
10,092,890 bp from pter |
End:
|
10,241,297 bp from pter |
Size:
|
148,408 bases |
Orientation:
|
plus strand |
|
Proteins
for UBE4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBE4B_HUMAN, O95155 (See
protein sequence)Recommended Name: Ubiquitin conjugation factor E4 B Size: 1302 amino acids; 146185 Da
Subunit: Interacts with VCP (By similarity)
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAA31659.3; Type=Erroneous initiation;
3 PDB 3D structures from  and Proteopedia  for UBE4B:2KRE (3D)
3L1X (3D)
3L1Z (3D)
Secondary accessions: O75169 O95338 Q5SZ12 Q5SZ16 Q96QD4 Q9BYI7Alternative splicing: 3 isoforms: O95155-1 O95155-2 O95155-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UBE4B: NX_O95155
Post-translational modifications:
Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B.Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-71
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95155
UBE4B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001099032.1 NP_006039.2
ENSEMBL proteins: ENSP00000253251 ENSP00000366358 ENSP00000343001 ENSP00000468472 ENSP00000467258 ENSP00000468178 ENSP00000366362
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
UBE4B for ontologies About GeneDecksing
UBE4B Antibody Products:
Assay Products for UBE4B: |
Protein
Domains /
Families
for UBE4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE4B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95155ProtoNet protein and cluster: O95155 1 Blocks protein family: IPB003613 Zn-finger
UniProtKB/Swiss-Prot: UBE4B_HUMAN, O95155Similarity: Belongs to the ubiquitin conjugation factor E4 familySimilarity: Contains 1 U-box domain |
Function
for UBE4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBE4B_HUMAN, O95155Function: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunctionwith E1, E2, and E3 (By similarity) Genatlas biochemistry entry for UBE4B:ubiquitination factor E4B (homologous to yeast UFD2),cDNA sequence,expressed in brain,required in 4A,related toDrosophila NOSA
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE4B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE4B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): UBE4B (NM_001105562) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE4B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE4B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE4B |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
UBE4B for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for UBE4B:
Animal Models:
Mouse knock-out Ube4btm1Kei for UBE4B
7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ube4b):
UBE4B for phenotypes About GeneDecksing
|
Pathways & Interactions
for UBE4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein processing in endoplasmic reticulum | | | 2 | Antigen processing: Ubiquitination & Proteasome degradation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for UBE4B):
UBE4B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE4B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/68 Interacting proteins for UBE4B (O951552, 3 ENSP000003430014) via UniProtKB, MINT, STRING, and/or I2D (see all 68)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
UBE4B for ontologies About GeneDecksing
|
Drugs & Compounds
for UBE4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBE4B
4 HMDB Compounds for UBE4B About this table
Search CenterWatch for drugs/clinical trials and news about UBE4B
|
Transcripts
for UBE4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBE4B gene (2 alternative transcripts): NM_001105562.2 NM_006048.4 Unigene Cluster for UBE4B: Ubiquitination factor E4B Hs.593974 [show with all ESTs]Unigene Representative Sequence: NM_00110556212 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000253251 ENST00000377153 ENST00000343090(uc001aqu.3) ENST00000495077
ENST00000462658 ENST00000475795 ENST00000470736 ENST00000466379 ENST00000488228
ENST00000487244 ENST00000465408 ENST00000377157(uc001aqs.4 uc001aqr.4 uc021ogc.1 uc010oai.2 uc010oaj.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE4B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE4B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): UBE4B (NM_001105562) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE4B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE4B |
Additional cDNA sequence: AB014584.3 AB028839.1 AF043117.1 AF091093.1 AF331520.1 AK023654.1 AK094380.1 AK292444.1 AK304484.1 BC047890.1 BC093696.1 BC143458.1 BC143460.1 JF289274.1 21 DOTS entries: DT.100797627 DT.92017320 DT.447531 DT.86852536 DT.91839394 DT.70103412 DT.97765132 DT.405791 DT.92037238 DT.95167147 DT.100797625 DT.100797631 DT.121423230 DT.92013086 DT.92438560 DT.95167157 DT.97786053 DT.102832074 DT.75125506 DT.91644723 DT.91745816 24/303 AceView cDNA sequences (see all 303): BQ001243 BM903907 AI082562 AA444067 BX398336 BP345456 AI918539 CR603512 AI375676 W52483 BF591244 BE048330 AA444047 AI582765 AI830215 AW501127 AA318371 H41897 W74337 AI282019 AI863867 BM263396 CB070251 CB529467
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for UBE4B (see all 12) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20b | ^ | 21 | ^ | 22a | · | 22b | · | 22c | ^ | 23 | ^ | 24a | · | 24b | ^ | 25a | · | 25b | ^ | 26 | ^ | 27a | · | 27b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UBE4B
|
Expression
for UBE4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBE4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTAATAAAA
About this image
See UBE4B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBE4B
SOURCE GeneReport for Unigene cluster: Hs.593974
UniProtKB/Swiss-Prot: UBE4B_HUMAN, O95155Tissue specificity: Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymusand peripheral blood leukocytes. Almost undetectable in lung and spleen
SABiosciences Expression via Pathway-Focused PCR Arrays including UBE4B:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE4B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE4B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE4B |
Orthologs
for UBE4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBE4B gene from 10/34 species (see all 34) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ube4b1 , 5 |
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)1, 5 |
89.15(n)1
96.96(a)1 |
|
4 (79.08 cM)5
639581 NM_022022.31 NP_071305.21
1493284165 |
chicken
(Gallus gallus) |
Aves |
UBE4B1 |
ubiquitination factor E4B |
80.57(n)
91.19(a) |
|
419448 XM_003642511.1 XP_003642559.1 |
lizard
(Anolis carolinensis) |
Reptilia |
UBE4B6 |
-- |
81(a) |
1 ↔ 1 |
GL343709.1(115784-171989) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.38892 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.43(n) |
|
BU913303.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ube4b2 |
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) |
76.62(n) |
|
170784 AY029484.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG99341 , 3 |
ubiquitin-dependent protein catabolism3
CG99341 |
41(a)3
50.66(n)1
42.97(a)1 |
|
34A43
346991 NM_001169496.11 NP_001162967.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
T05H10.5a3
ufd-21 |
Protein UFD-21 |
29(a)
(best of 2)3
44.65(n)1
32.34(a)1 |
|
II(8062674-8065865)3
1742951 NM_063291.21 NP_495692.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
UFD2(YDL190C)4
UFD21 |
Ubiquitin chain assembly factor (E4) that cooperates more4
Ufd2p1 |
44.73(n)1
32.34(a)1 |
|
4(121592-118707)4
8513371, 4 NP_010091.21 NP_010091.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G154001 |
putative ubiquitin conjugation factor E4 |
45.05(n)
33.72(a) |
|
831392 NM_121544.3 NP_568313.2 |
rice
(Oryza sativa) |
Liliopsida |
-- |
U-box domain-containing protein, putative, express... |
24(a) |
1 ↔ 1 |
3(17883675-17890797) |
ENSEMBL Gene Tree for UBE4B (if available)
TreeFam Gene Tree for UBE4B (if available) |
Paralogs
for UBE4B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBE4B gene
- UBE4A2
1 SIMAP similar gene for UBE4B using alignment to 5 protein entries: UBE4B_HUMAN (see all proteins):Ube4B
UBE4B for paralogs About GeneDecksing
|
Genomic Variants
for UBE4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBE4B (10092890 - 10241297 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for UBE4B
2 CNVs: 3281 97288 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE4B |
|
Disorders
/ Diseases
for UBE4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBE4B for disorders About GeneDecksing
OMIM gene information: 613565
OMIM disorders: --
12  diseases for UBE4B: About MalaCardsneuroblastoma wallerian degeneration neuroblastoma 1 hepatitis b
conjunctivitis hepatocellular carcinoma hepatitis obesity
carcinoma neuronitis pancreatic cancer pancreatitis
Human Genome Epidemiology (HuGE) Navigator: UBE4B (2 documents)
Export disorders for UBE4B gene to outside databases
|
Publications
for UBE4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBE4B gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with UBE4B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
- The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis. (PubMed id 11802788)1, 2, 9 Mahoney J.A.... Rosen A. (2002)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line. (PubMed id 10980605)1, 2 Ohira M....Nakagawara A. (2000)
- A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. (PubMed id 10089879)1, 3 Koegl M....Jentsch S. (1999)
- Molecular cloning and expression analysis of five novel genes in chromosome 1p36. (PubMed id 9653645)1, 2 Onyango P.... Weith A. (1998)
- Molecular clearance of ataxin-3 is regulated by a mammalian E4. (PubMed id 14749733)1, 9 Matsumoto M....Nakayama K.I. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for UBE4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBE4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBE4B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing UBE4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for UBE4B gene:
Search GeneIP for patents involving UBE4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBE4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for UBE4B | | OriGene shRNA RFP for UBE4B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBE4B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE4B | | | OriGene Protein Over-expression Lysate for UBE4B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBE4B | | OriGene 3'-UTR Clone for UBE4B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE4B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE4B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UBE4B | | OriGene Custom Protein Services for UBE4B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBE4B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE4B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE4B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE4B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for UBE4B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | UBE4B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE4B |
|  |  |  | | | | ThermoFisher Antibodies for UBE4B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE4B |
|
|
|
|
