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UBE4B Gene

protein-coding   GIFtS: 67
GCID: GC01P010092

Ubiquitination Factor E4B

(Previous names: ubiquitination factor E4B (homologous to yeast UFD2), ubiquitination...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitination Factor E4B1 2     KIAA06843 5
Ubiquitination Factor E4B (Homologous To Yeast UFD2)1 2     E42
Ubiquitination Factor E4B (UFD2 Homolog, Yeast)1 2     UBOX32
Homozygously Deleted In Neuroblastoma 12 3     Homologous To Yeast UFD22
Ubiquitin Fusion Degradation Protein 22 3     Homozygously Deleted In Neuroblastoma-12
HDNB12 3     Ubiquitin Conjugation Factor E4 B2
UFD22 3     Ubiquitin-Fusion Degradation Protein 22
UFD2A2 5     UFD2A-III/UBE4B-III Splice Isoform2

External Ids:    HGNC: 125001   Entrez Gene: 102772   Ensembl: ENSG000001309397   OMIM: 6135655   UniProtKB: O951553   

Export aliases for UBE4B gene to outside databases

Previous GC identifers: GC01P010054 GC01P009937 GC01P009702 GC01P009803 GC01P009802 GC01P010027 GC01P009247


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE4B Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly.
This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced
transcript variants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBE4B Gene:
UBE4B (ubiquitination factor E4B) is a protein-coding gene. Diseases associated with UBE4B include neuroblastoma 1, and neuroblastoma. GO annotations related to this gene include ubiquitin-ubiquitin ligase activity and enzyme binding. An important paralog of this gene is UBE4A.

UniProtKB/Swiss-Prot: UBE4B_HUMAN, O95155
Function: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in
conjunction with E1, E2, and E3 (By similarity)

Gene Wiki entry for UBE4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE4B gene promoter:
         MAZR   Sp1   NF-kappaB   E47   CREB   FOXC1   NF-kappaB2   deltaCREB   Hand1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UBE4B promoter sequence
   Search Chromatin IP Primers for UBE4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.1

UBE4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE4B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P010092:  view genomic region     (about GC identifiers)

Start:
10,092,890 bp from pter      End:
10,241,297 bp from pter
Size:
148,408 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBE4B_HUMAN, O95155 (See protein sequence)
Recommended Name: Ubiquitin conjugation factor E4 B  
Size: 1302 amino acids; 146185 Da
Subunit: Interacts with VCP (By similarity)
Sequence caution: Sequence=BAA31659.3; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for UBE4B:
2KRE (3D)        3L1X (3D)        3L1Z (3D)    
Secondary accessions: A8K8S9 G0ZJH6 O75169 O95338 Q5SZ12 Q5SZ16 Q96QD4 Q9BYI7
Alternative splicing: 4 isoforms:  O95155-1   O95155-2   O95155-3   O95155-4   (Expressed exclusively in mature striated muscle cells)

Explore the universe of human proteins at neXtProt for UBE4B: NX_O95155

Explore proteomics data for UBE4B at MOPED

Post-translational modifications: 

  • Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B.
    Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-71
  • Ubiquitination2 at Lys610, Lys794, Lys801, Lys951, Lys964, Lys989, Lys1106, Lys1189
  • Modification sites at PhosphoSitePlus

  • See UBE4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001099032.1  NP_006039.2  

    ENSEMBL proteins: 
     ENSP00000253251   ENSP00000366358   ENSP00000343001   ENSP00000467258   ENSP00000468178  
     ENSP00000366362  

    UBE4B Human Recombinant Protein Products:

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    Novus Biologicals UBE4B Protein
    Novus Biologicals UBE4B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBE4B

    UBE4B Antibody Products:

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    Abcam antibodies for UBE4B
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    ThermoFisher Antibodies for UBE4B
    LSBio Antibodies in human, mouse, rat for UBE4B

    UBE4B Assay Products:

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    Cloud-Clone Corp. ELISAs for UBE4B
    Cloud-Clone Corp. CLIAs for UBE4B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBOX: U-box domain containing

    3 InterPro protein domains:
     IPR003613 Ubox_domain
     IPR019474 Ub_conjug_fac_E4_core
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry O95155

    ProtoNet protein and cluster: O95155

    1 Blocks protein domain: IPB003613 Zn-finger

    UniProtKB/Swiss-Prot: UBE4B_HUMAN, O95155
    Similarity: Belongs to the ubiquitin conjugation factor E4 family
    Similarity: Contains 1 U-box domain


    UBE4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBE4B_HUMAN, O95155
    Function: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in
    conjunction with E1, E2, and E3 (By similarity)

         Genatlas biochemistry entry for UBE4B:
    ubiquitination factor E4B (homologous to yeast UFD2),cDNA sequence,expressed in brain,required in 4A,related to
    Drosophila NOSA

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ----
    GO:0005515protein binding ----
    GO:0019899enzyme binding ISS--
    GO:0034450ubiquitin-ubiquitin ligase activity IEA--
         
    UBE4B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for UBE4B:
     Increased cell death HMECs cel  Synthetic lethal with c-Myc af 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ube4b):
     behavior/neurological  cardiovascular system  cellular  homeostasis/metabolism  mortality/aging 
     muscle  nervous system 

    UBE4B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ube4btm1Kei for UBE4B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE4B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE4B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE4B

    miRNA
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    miRTarBase miRNAs that target UBE4B:
    hsa-mir-423-3p (MIRT042528), hsa-mir-335-5p (MIRT016837), hsa-mir-92a-3p (MIRT049579)

    Block miRNA regulation of human, mouse, rat UBE4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE4B (see all 25):
    hsa-miR-21* hsa-miR-607 hsa-miR-148b hsa-miR-15a hsa-miR-503 hsa-miR-500a hsa-miR-1297 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidUBE4B 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UBE4B
    Predesigned siRNA for gene silencing in human, mouse, rat UBE4B

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): UBE4B (NM_001105562)
    Sino Biological Human cDNA Clone for UBE4B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE4B

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE4B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBE4B_HUMAN, O95155: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex TAS11802788
    GO:0005737cytoplasm ISS--

    UBE4B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE4B About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Ubiquitin mediated proteolysis0.35
    2Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for UBE4B):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum


    UBE4B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBE4B: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UBE4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE4B (O951552, 3 ENSP000003430014) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCPP550722, 3, ENSP000003517774MINT-2838485 I2D: score=13 STRING: ENSP00000351777
    CDKN2AP427713, ENSP000003551534I2D: score=1 I2D: score=1 STRING: ENSP00000355153
    NSFL1CQ9UNZ23, ENSP000002168794I2D: score=4 STRING: ENSP00000216879
    CASP3P425743, ENSP000003110324I2D: score=2 STRING: ENSP00000311032
    UBXN1Q043233, ENSP000002941194I2D: score=2 STRING: ENSP00000294119
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0008626granzyme-mediated apoptotic signaling pathway IDA11802788
    GO:0009411response to UV IDA11802788
    GO:0016567protein ubiquitination ----
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS11802788

    UBE4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE4B

    4 HMDB Compounds for UBE4B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UBE4B gene (2 alternative transcripts): 
    NM_001105562.2  NM_006048.4  

    Unigene Cluster for UBE4B:

    Ubiquitination factor E4B
    Hs.593974  [show with all ESTs]
    Unigene Representative Sequence: NM_001105562
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253251 ENST00000377153 ENST00000343090(uc001aqu.3) ENST00000462658
    ENST00000475795 ENST00000470736 ENST00000466379 ENST00000488228 ENST00000487244
    ENST00000465408 ENST00000377157(uc001aqs.4 uc001aqr.4 uc021ogc.1 uc010oai.2 uc010oaj.2)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate UBE4B (see all 25):
    hsa-miR-21* hsa-miR-607 hsa-miR-148b hsa-miR-15a hsa-miR-503 hsa-miR-500a hsa-miR-1297 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidUBE4B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UBE4B
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UBE4B (NM_001105562)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE4B
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE4B
      QuantiTect SYBR Green Assays in human, mouse, rat UBE4B
      QuantiFast Probe-based Assays in human, mouse, rat UBE4B

    Additional mRNA sequence: 

    AB014584.3 AB028839.1 AF043117.1 AF091093.1 AF331520.1 AK023654.1 AK094380.1 AK292444.1 
    AK304484.1 BC047890.1 BC093696.1 BC143458.1 BC143460.1 JF289274.1 

    21 DOTS entries:

    DT.100797627  DT.92017320  DT.447531  DT.86852536  DT.91839394  DT.70103412  DT.97765132  DT.405791 
    DT.92037238  DT.95167147  DT.100797625  DT.100797631  DT.121423230  DT.92013086  DT.92438560  DT.95167157 
    DT.97786053  DT.102832074  DT.75125506  DT.91644723  DT.91745816 

    Selected AceView cDNA sequences (see all 303):

    CB070251 BQ687232 AA444067 AA281254 BQ019962 BQ001243 AI245548 NM_006048 
    BU624533 BE348687 AA575891 AI804948 AI419951 CB529467 BM263396 AI863867 
    AI282019 W74337 AI082562 BU521574 BE908366 BX398336 AW501127 H41897 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBE4B (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
    SP1:                                                                                            -                                                               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                      -                                       
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for UBE4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTAATAAAA
    UBE4B Expression
    About this image


    UBE4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Thymus (Hematopoietic System)
             Thymus
     
     Kidney (Urinary System)
             Metanephros
    UBE4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.593974

    UniProtKB/Swiss-Prot: UBE4B_HUMAN, O95155
    Tissue specificity: Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon,
    thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBE4B: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UBE4B
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE4B gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube4b1 , 5 ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)5
    ubiquitination factor E4B1
    89.64(n)1
    97.52(a)1
      4 (79.08 cM)5
    639581  NM_022022.31  NP_071305.21 
     1493284165 
    chicken
    (Gallus gallus)
    Aves UBE4B1 ubiquitination factor E4B 79.82(n)
    88.85(a)
      419448  XM_004947453.1  XP_004947510.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE4B6
    ubiquitination factor E4B
    67(a)
    1 ↔ 1
    GL343709.1(114086-185124)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.38892 Xenopus laevis transcribed sequence with moderate similarity more 78.43(n)    BU913303.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ube4b2 ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) 76.62(n)   170784  AY029484.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG99341 , 3 ubiquitin-dependent protein catabolism3
    CG99341
    41(a)3
    50.49(n)1
    42.94(a)1
      34A43
    346991  NM_135753.41  NP_609597.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T05H10.5a3
    ufd-21
    ufd-21 29(a)
    (best of 2)3
    44.84(n)1
    32.91(a)1
      II(8062674-8065865)3
    1742951  NM_063290.11  NP_495691.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UFD2(YDL190C)4
    UFD21
    Ubiquitin chain assembly factor (E4) that cooperates more4
    UFD21
    45.03(n)1
    33.28(a)1
      4(121592-118707)4
    8513371, 4  NP_010091.21  NP_010091.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G154001 AT5G15400 44.9(n)
    33.94(a)
      831392  NM_121544.3  NP_568313.2 


    ENSEMBL Gene Tree for UBE4B (if available)
    TreeFam Gene Tree for UBE4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE4B gene
    UBE4A2  

    UBE4B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE4B (see all 2753)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs121372351,2
    C--10091045(+) atatgC/Ttaagt 2 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1145254991,2
    F--10091078(+) CCACAC/TGGTGT 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1394988691,2
    --10091096(+) CACTGA/CTGTGA 2 -- us2k10--------
    rs1480199861,2
    C--10091156(+) GAGTC-/TTTTTT 2 -- us2k10--------
    rs1452958041,2
    --10091204(+) AGTGCA/CGTGGC 2 -- us2k10--------
    rs1812791701,2
    --10091211(+) TGGCAC/TGATCT 2 -- us2k10--------
    rs66579251,2
    C--10091290(+) ttacaC/Ggtgcc 2 -- us2k10--------
    rs1854831111,2
    C--10091438(+) CCCGGG/TAGTGA 2 -- us2k10--------
    rs1908766411,2
    C--10091486(+) AAAATA/GTTCTG 2 -- us2k10--------
    rs1821430691,2
    --10091653(+) ACACAA/GAATTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBE4B (10092890 - 10241297 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for UBE4B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2562286CNV Deletion19546169
    esv2668231CNV Deletion23128226
    dgv12e199CNV Deletion23128226
    nsv522629CNV Gain19592680
    nsv527217CNV Gain19592680
    nsv525216CNV Gain19592680
    dgv17e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for UBE4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613565    OMIM disorders: --

    15 diseases for UBE4B:    
    About MalaCards
    neuroblastoma 1    neuroblastoma    wallerian degeneration    conjunctivitis
    labyrinthitis    obesity    hepatitis b    pancreatic cancer
    pancreatitis    hepatocellular carcinoma    hepatitis    thyroiditis
    cerebritis    malaria    neuronitis


    UBE4B for disorders           About GeneDecksing

    Genetic Association Database (GAD): UBE4B
    Human Genome Epidemiology (HuGE) Navigator: UBE4B (2 documents)

    Export disorders for UBE4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE4B gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with UBE4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    2. The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis. (PubMed id 11802788)1, 2, 9 Mahoney J.A.... Rosen A. (Biochem. J. 2002)
    3. A Novel Conserved Isoform of the Ubiquitin Ligase UFD2a/UBE4B Is Expressed Exclusively in Mature Striated Muscle Cells. (PubMed id 22174917)1, 2 Mammen A.L.... Spinette S. (PLoS ONE 2011)
    4. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. (PubMed id 20676096)1, 4 Zhang H....Zhou G. (Nat. Genet. 2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line. (PubMed id 10980605)1, 2 Ohira M....Nakagawara A. (Oncogene 2000)
    10. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. (PubMed id 10089879)1, 3 Koegl M....Jentsch S. (Cell 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10277 HGNC: 12500 AceView: UBE4B Ensembl:ENSG00000130939 euGenes: HUgn10277
    ECgene: UBE4B Kegg: 10277 H-InvDB: UBE4B

    (According to HUGE)
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    HUGE: KIAA0684

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE4B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBE4B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE4B gene:
    Search GeneIP for patents involving UBE4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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