Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBE4B Gene

Aliases for UBE4B Gene

  • Ubiquitination Factor E4B 2 3
  • Ubiquitination Factor E4B (Homologous To Yeast UFD2) 2 3
  • Ubiquitination Factor E4B (UFD2 Homolog, Yeast) 2 3
  • Homozygously Deleted In Neuroblastoma 1 3 4
  • Ubiquitin Fusion Degradation Protein 2 3 4
  • KIAA0684 4 6
  • UFD2A 3 6
  • HDNB1 3 4
  • UFD2 3 4
  • Homozygously Deleted In Neuroblastoma-1 3
  • Ubiquitin-Fusion Degradation Protein 2 3
  • UFD2A-III/UBE4B-III Splice Isoform 3
  • Ubiquitin Conjugation Factor E4 B 3
  • Homologous To Yeast UFD2 3
  • EC 6.3.2.- 4
  • UBOX3 3
  • E4 3

External Ids for UBE4B Gene

Previous GeneCards Identifiers for UBE4B Gene

  • GC01P010054
  • GC01P009937
  • GC01P009702
  • GC01P009803
  • GC01P009802
  • GC01P010027
  • GC01P010092
  • GC01P009247

Summaries for UBE4B Gene

Entrez Gene Summary for UBE4B Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE4B Gene

UBE4B (Ubiquitination Factor E4B) is a Protein Coding gene. Diseases associated with UBE4B include neuroblastoma and wallerian degeneration. Among its related pathways are Protein processing in endoplasmic reticulum and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include enzyme binding and ubiquitin-ubiquitin ligase activity. An important paralog of this gene is UBE4A.

UniProtKB/Swiss-Prot for UBE4B Gene

  • Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase.

Gene Wiki entry for UBE4B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE4B Gene

Genomics for UBE4B Gene

Regulatory Elements for UBE4B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBE4B Gene

10,032,832 bp from pter
10,181,239 bp from pter
148,408 bases
Plus strand

Genomic View for UBE4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE4B Gene

Proteins for UBE4B Gene

  • Protein details for UBE4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin conjugation factor E4 B
    Protein Accession:
    Secondary Accessions:
    • A8K8S9
    • G0ZJH6
    • O75169
    • O95338
    • Q5SZ12
    • Q5SZ16
    • Q96QD4
    • Q9BYI7

    Protein attributes for UBE4B Gene

    1302 amino acids
    Molecular mass:
    146185 Da
    Quaternary structure:
    • Interacts with VCP.
    • Sequence=BAA31659.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE4B Gene

    Alternative splice isoforms for UBE4B Gene


neXtProt entry for UBE4B Gene

Proteomics data for UBE4B Gene at MOPED

Post-translational modifications for UBE4B Gene

  • Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7.
  • Ubiquitination at Lys610, Lys794, Lys801, Lys951, Lys964, Lys989, Lys1106, and Lys1189
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE4B Gene

No data available for DME Specific Peptides for UBE4B Gene

Domains for UBE4B Gene

Gene Families for UBE4B Gene

  • UBOX :U-box domain containing

Protein Domains for UBE4B Gene

Suggested Antigen Peptide Sequences for UBE4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O95155
  • The U-box domain is required for the ubiquitin protein ligase activity.
  • Contains 1 U-box domain.
  • Belongs to the ubiquitin conjugation factor E4 family.
genes like me logo Genes that share domains with UBE4B: view

Function for UBE4B Gene

Molecular function for UBE4B Gene

GENATLAS Biochemistry: ubiquitination factor E4B (homologous to yeast UFD2),cDNA sequence,expressed in brain,required in 4A,related to Drosophila NOSA
UniProtKB/Swiss-Prot Function: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase.

Enzyme Numbers (IUBMB) for UBE4B Gene

Gene Ontology (GO) - Molecular Function for UBE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity --
GO:0005515 protein binding --
GO:0016874 ligase activity IEA --
GO:0019899 enzyme binding ISS --
GO:0034450 ubiquitin-ubiquitin ligase activity IEA --
genes like me logo Genes that share ontologies with UBE4B: view
genes like me logo Genes that share phenotypes with UBE4B: view

Animal Models for UBE4B Gene

MGI Knock Outs for UBE4B:

Animal Model Products

CRISPR Products

miRNA for UBE4B Gene

miRTarBase miRNAs that target UBE4B

No data available for Transcription Factor Targeting and HOMER Transcription for UBE4B Gene

Localization for UBE4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE4B Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for UBE4B Gene COMPARTMENTS Subcellular localization image for UBE4B gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for UBE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex TAS 11802788
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with UBE4B: view

Pathways for UBE4B Gene

genes like me logo Genes that share pathways with UBE4B: view

Pathways by source for UBE4B Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot O95155-UBE4B_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0008626 granzyme-mediated apoptotic signaling pathway IDA 11802788
GO:0009411 response to UV IDA 11802788
GO:0016567 protein ubiquitination --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS 11802788
genes like me logo Genes that share ontologies with UBE4B: view

Compounds for UBE4B Gene

(4) HMDB Compounds for UBE4B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with UBE4B: view

Transcripts for UBE4B Gene

Unigene Clusters for UBE4B Gene

Ubiquitination factor E4B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE4B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE4B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: -
SP8: -
SP12: -

ExUns: 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b
SP3: -
SP6: -
SP7: -

Relevant External Links for UBE4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBE4B Gene

mRNA expression in normal human tissues for UBE4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE4B Gene

SOURCE GeneReport for Unigene cluster for UBE4B Gene Hs.593974

mRNA Expression by UniProt/SwissProt for UBE4B Gene

Tissue specificity: Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen.
genes like me logo Genes that share expressions with UBE4B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UBE4B Gene

Orthologs for UBE4B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE4B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBE4B 35
  • 99.74 (n)
  • 99.77 (a)
UBE4B 36
  • 100 (a)
(Bos Taurus)
Mammalia UBE4B 35
  • 90.52 (n)
  • 96.31 (a)
UBE4B 36
  • 92 (a)
(Canis familiaris)
Mammalia UBE4B 35
  • 91.6 (n)
  • 96.7 (a)
UBE4B 36
  • 92 (a)
(Mus musculus)
Mammalia Ube4b 35
  • 89.64 (n)
  • 97.52 (a)
Ube4b 16
Ube4b 36
  • 97 (a)
(Monodelphis domestica)
Mammalia UBE4B 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
-- 36
  • 94 (a)
-- 36
  • 97 (a)
-- 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Ube4b 35
  • 89.56 (n)
  • 97.43 (a)
(Gallus gallus)
Aves UBE4B 35
  • 79.82 (n)
  • 88.85 (a)
UBE4B 36
  • 86 (a)
(Anolis carolinensis)
Reptilia UBE4B 36
  • 67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3889 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16539 35
ube4b 35
  • 76.2 (n)
  • 86.34 (a)
(Danio rerio)
Actinopterygii ube4b 35
  • 73.66 (n)
  • 81.25 (a)
ube4b 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007870 35
  • 51.31 (n)
  • 44.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9934 35
  • 50.49 (n)
  • 42.94 (a)
CG9934 36
  • 32 (a)
CG9934 37
  • 41 (a)
(Caenorhabditis elegans)
Secernentea ufd-2 35
  • 44.84 (n)
  • 32.91 (a)
ufd-2 36
  • 28 (a)
T05H10.5a 37
  • 29 (a)
T05H10.5b 37
  • 29 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR096C 35
  • 44.02 (n)
  • 31.78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UFD2 35
  • 45.03 (n)
  • 33.28 (a)
UFD2 36
  • 25 (a)
UFD2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F05269g 35
  • 43.41 (n)
  • 30.58 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G15400 35
  • 44.9 (n)
  • 33.94 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03357 35
  • 44.08 (n)
  • 33.46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ufd2 35
  • 43.71 (n)
  • 33.96 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5759 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
CSA.4101 36
  • 62 (a)
Species with no ortholog for UBE4B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE4B Gene

Gene Tree for UBE4B (if available)
Gene Tree for UBE4B (if available)

Paralogs for UBE4B Gene

Paralogs for UBE4B Gene

genes like me logo Genes that share paralogs with UBE4B: view

Variants for UBE4B Gene

Sequence variations from dbSNP and Humsavar for UBE4B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs15191 -- 10,179,520(+) CGGAC(A/C)CCTTC missense, reference
rs1046277 -- 10,180,036(+) GCTGC(C/T)GTTCA utr-variant-3-prime
rs1074461 -- 10,143,387(-) GCCTC(A/G)CTCTA intron-variant
rs1801442 -- 10,171,204(+) AGTGC(C/G)GTGAC reference, missense
rs1830501 -- 10,136,641(+) CTggc(C/G)gggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE4B Gene

Variant ID Type Subtype PubMed ID
nsv527217 CNV Gain 19592680
dgv12e199 CNV Deletion 23128226
nsv522629 CNV Gain 19592680
esv2668231 CNV Deletion 23128226
nsv525216 CNV Gain 19592680
esv2562286 CNV Deletion 19546169
dgv17e1 CNV Complex 17122850

Relevant External Links for UBE4B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE4B Gene

Disorders for UBE4B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for UBE4B Gene including...

Search for UBE4B Gene in MalaCards »

Relevant External Links for UBE4B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with UBE4B: view

No data available for UniProtKB/Swiss-Prot for UBE4B Gene

Publications for UBE4B Gene

  1. The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis. (PMID: 11802788) Mahoney J.A. … Rosen A. (Biochem. J. 2002) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  3. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. (PMID: 10089879) Koegl M. … Jentsch S. (Cell 1999) 2 3
  4. Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line. (PMID: 10980605) Ohira M. … Nakagawara A. (Oncogene 2000) 3 4
  5. Molecular clearance of ataxin-3 is regulated by a mammalian E4. (PMID: 14749733) Matsumoto M. … Nakayama K.I. (EMBO J. 2004) 3 23

Products for UBE4B Gene

Sources for UBE4B Gene

Back to Top