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UBE4B Gene

protein-coding GIFtS: 65

GC01P010027

ubiquitination factor E4B (UFD2 homolog, yeast)
(Previous name: ubiquitination factor E4B (homologous to yeast UFD2) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
E4 ^¹, ²
HDNB1 ^², ³
KIAA0684 ^¹, ², ³
OTTHUMP00000001726 ^²
OTTHUMP00000001727 ^²
UBOX3 ^¹, ²
UFD2 ^¹, ², ³

Descriptions
Homozygously deleted in neuroblastoma 1 ^³
Ubiquitin fusion degradation protein 2 ^³
homologous to yeast UFD2 ^²
homozygously deleted in neuroblastoma-1 ^²
ubiquitin-fusion degradation protein 2 ^²
ubiquitination factor E4B ^²
ubiquitination factor E4B (UFD2 homolog, yeast) ^²
ubiquitination factor E4B (homologous to yeast UFD2) ^¹, ²

External Ids
HGNC: 12500¹
Entrez Gene: 10277²
UniProtKB: O95155³
Ensembl: ENSG00000130939⁷

Search outside databases for aliases for UBE4B gene

Previous GC identifers: GC01P010054 GC01P009937 GC01P009702 GC01P009803 GC01P009802

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBE4B:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting

abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes

of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and

ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which

is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the

neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct

isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBE4B_HUMAN, O95155

Function: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain

assembly in conjunction with E1, E2, and E3 (By similarity)

Gene Wiki entry for UBE4B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBE4B gene

Entrez Gene cytogenetic band: 1p36.3 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.1

UBE4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P010027: (about GC identifiers)

Start:	10,015,603 bp from pter
End:	10,163,884 bp from pter
Size:	148,282 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_021937.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBE4B_HUMAN, O95155 (See protein sequence)

Recommended Name: Ubiquitin conjugation factor E4 B

Size: 1302 amino acids; 146185 Da

Subunit: Interacts with VCP (By similarity)

Subcellular location: Cytoplasm (By similarity)

Secondary accessions: O75169 O95338 Q5SZ12 Q5SZ16 Q96QD4 Q9BYI7

Alternative splicing: 3 isoforms: O95155-1 O95155-2 O95155-3

Post-translational modifications:

Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6

and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and

caspase-7¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001099032.1 NP_006039.2

ENSEMBL proteins:

ENSP00000366362 ENSP00000366358 ENSP00000383693 ENSP00000343001 ENSP00000253251

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (UBE4B)
	Human Recombinant Proteins from Abnova (UBE4B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000151	ubiquitin ligase complex	TAS	11802788
GO:0005737	cytoplasm	ISS	--

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Antibodies for UBE4B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for UBE4B
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (UBE4B), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE4B)
	Novus Biologicals Antibodies for UBE4B

Assays for UBE4B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O95155

ProtoNet protein and cluster: O95155

1 Blocks protein family: IPB003613 Zn-finger

UniProtKB/Swiss-Prot: UBE4B_HUMAN, O95155

Similarity: Belongs to the ubiquitin conjugation factor E4 family

Similarity: Contains 1 U-box domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE4B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE4B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001105562

Applied Biosystems Silencer® siRNAs for UBE4B

Sigma-Aldrich siRNA and siRNA Panels for UBE4B

Sigma-Aldrich shRNA Panels and shRNA for UBE4B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001105562
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001105562
untagged cDNA clones in CMV expression vector (see all 2): NM_001105562

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001105562

UniProtKB/Swiss-Prot: UBE4B_HUMAN, O95155

Function: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain

assembly in conjunction with E1, E2, and E3 (By similarity)

Genatlas biochemistry entry for UBE4B:

ubiquitination factor E4B (homologous to yeast UFD2),cDNA sequence,expressed in brain,required in

4A,related to Drosophila NOSA

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ube4b):

	behavior/neurological	cellular	homeostasis/metabolism	lethality-prenatal/perinatal
muscle	nervous system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IEA	--
GO:0019899	enzyme binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for UBE4B (Your Favorite Gene powered by Ingenuity)

Protein Ubiquitination Pathway

GeneDecks UBE4B for the pathways selected above

About GeneDecksing

5/34 Interacting proteins for UBE4B (ENSP00000343001³ O95155²) via UniProtKB, MINT, and/or STRING (see all 34 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VCP	P55072²	STRING (score=.994) MINT-2838485
UBE4A	ENSP00000252108³	STRING (score=.918)
ARIH1	ENSP00000369217³	STRING (score=.899)
BARD1	ENSP00000260947³	STRING (score=.899)
BRCA1	ENSP00000350283³	STRING (score=.899)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptosis	IDA	11802788
GO:0009411	response to UV	IDA	11802788
GO:0019941	modification-dependent protein catabolic process	IEA	--
GO:0042787	protein ubiquitination during ubiquitin-dependent protein catabolic process	TAS	11802788

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE4B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE4B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE4B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001105562

Sigma-Aldrich siRNA and siRNA Panels for UBE4B

Sigma-Aldrich shRNA Panels and shRNA for UBE4B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001105562 NM_006048

REFSEQ mRNAs for UBE4B gene (2 alternative transcripts):

NM_001105562.1 NM_006048.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001105562 NM_006048

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001105562
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001105562
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001105562

Additional cDNA sequence:

AB014584.3 AB028839.1 AF043117.1 AF091093.1 AF331520.1 AK023654.1 AK094380.1 AK292444.1

AK304484.1 BC047890.1 BC093696.1 BC143458.1 BC143460.1 CR603512.1

23 DOTS entries:

DT.100797627 DT.92017320 DT.447531 DT.86852536 DT.91839394 DT.97765132 DT.70103412 DT.102832074

DT.405791 DT.75125506 DT.92037238 DT.95167147 DT.95167157 DT.100797625 DT.100797631 DT.121423204

DT.121423230 DT.91745816 DT.92013086 DT.92438560 DT.97786053 DT.75111177 DT.91644723

24/303 AceView cDNA sequences (see all 303 ):

BP341523 AI952446 BQ962638 AI880573 BM722558 AA575891 BQ001243 BF116124

BE908366 AA281254 BQ687232 AB014584 BM450011 AA444067 BQ019962 BM903907

BP345456 AI375676 AI245548 AI582765 AA444047 CD652138 BC047890 AA361441

highest scoring ESTs for UBE4B:

AB014584 AF043117 AA024850 AA024887 AA128625 AA173048 AA224403 AA224453 AA251761 AA257050

Unigene Cluster for UBE4B:

Ubiquitination factor E4B (UFD2 homolog, yeast)

Hs.632370 [show with all ESTs]

Unigene Representative Sequence: NM_001105562

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for UBE4B (see all 12 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19a	·	19b	^	20a	·
SP1:																															-
SP2:
SP3:
SP4:
SP5:

ExUns:	20b	^	21	^	22a	·	22b	·	22c	^	23	^	24a	·	24b	^	25a	·	25b	^	26	^	27a	·	27b
SP1:
SP2:
SP3:													-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for UBE4B

5 Ensembl transcripts including schematic representations:

ENST00000377157 ENST00000377153 ENST00000400901 ENST00000343090 ENST00000253251

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBE4B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE4B

¹ / ² / ³

10 probe-sets matching UBE4B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41339_at²^{, 3}	U95-A	1	1.00	1.00	0.91	1.05	AF043117	1.00	0.90	0.95	1
33884_s_at²^{, 3}	U95-A	1	1.00	1.00	0.88	0.95	AB014584	1.00	0.90	0.95	1
215533_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF091093	0.80	1.00	0.91	1
202317_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006048	0.60	1.00	0.82	1
210685_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB028839	0.80	0.88	0.84	1
202316_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW241715	0.80	1.00	0.91	1
215533_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202317_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210685_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202316_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATTAATAAAA

SOURCE GeneReport for Unigene cluster: Hs.632370
Expression variation in blood from EXPOLDB for UBE4B
UniProtKB/Swiss-Prot: UBE4B_HUMAN, O95155
Tissue specificity: Highest expression in ovary, testis, heart and skeletal muscle. Expression is
low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE4B gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	UBE4B¹	--	ubiquitination factor E4B (UFD2 homolog, yeast)	99.74(n) 99.77(a)	457924 XM_001161430.1 XP_001161430.1
rat (Rattus norvegicus)	Ube4b¹	--	ubiquitination factor E4B	88.27(n) 96.01(a)	298652 XM_233679.3 XP_233679.3
mouse (Mus musculus)	Ube4b^{1, 5}	4 (76.40 cM)⁵	ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)^{1, 5}	89.07(n)¹ 96.88(a)¹	63958¹ NM_022022.2¹ NP_071305.1¹ AB083274⁵ AF072730⁵ (see all 29)
chicken (Gallus gallus)	UBE4B¹	--	ubiquitination factor E4B (UFD2 homolog, yeast)	80.28(n) 88.71(a)	419448 XM_417607.2 XP_417607.2
zebrafish (Danio rerio)	ube4b²	--	ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)	76.62(n)	170784 AY029484.1

About this table Species with no ortholog for UBE4B

ENSEMBL Gene Tree for UBE4B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for UBE4B gene

UBE4A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/503 NCBI SNPs in UBE4B are shown (see all 503 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 96)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs4846195^1,2	A,C,F,H	10164174(+)	`TCAGGC/TCGGGC`	2	--	ng3¹		4		EU EA WA	420
	rs7528979^1,2	A,C,F,H	10016044(+)	`TAAGAC/TAACCC`	2	--	ut5¹ ese³		5		EU EA WA	596
	rs17034499^1,2	C,F,H	10113360(+)	`TCCAGG/ATTAAA`	2	I/V	mis¹		11		NA EU EA WA	980
	rs1046277^1,2	F,H	10162681(+)	`GCTGCC/TGTTCA`	2	--	ut3¹ ese³		5		MN EU EA WA	604
	rs6541075^1,2	A,C	10015357(+)	`TCCCCA/TTGCCA`	2	--	ng5¹ trp³		0	--	--	--	--
--	rs4846196^1,2	C	10164227(+)	`ggcggA/Gtggat`	2	--	ng3¹		0	--	--	--	--
	rs2273299^1,2	A,C,F,H,O	10141026(+)	`ACCAGT/CGAGTT`	2	S/S	syn¹ ese³		14		EA MN NA EU WA	2347
	rs7546642^1,2	C,F,H	10161357(+)	`TCCACA/GATAGC`	2	T/T	syn¹ ese³		4		EU EA WA	420
	rs7414561^1,2	A,H	10119752(+)	`CCTACG/TGAGTG`	2	T/T	syn¹ ese³		4		EU EA WA	418
	rs2295294^1,2	A,C,F,H,O	10113471(+)	`TTCAGA/TAAACA`	2	--	int¹		14		EA NA EU WA	2734

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HapMap Linkage Disequilibrium images for UBE4B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/23 PubMed articles for UBE4B gene (see all 23 ):

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{2, 3, 4} Ishikawa K....Ohara O. (1998)
The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis. (PubMed id 11802788)^{1, 3, 4} Mahoney J.A.... Rosen A. (2002)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line. (PubMed id 10980605)^{3, 4} Ohira M....Nakagawara A. (2000)
A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. (PubMed id 10089879)^{2, 3} Koegl M....Jentsch S. (1999)
Molecular cloning and expression analysis of five novel genes in chromosome 1p36. (PubMed id 9653645)^{3, 4} Onyango P.... Weith A. (1998)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)⁴ Cantin G.T....Yates J.R. III (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10277	HGNC: 12500	AceView: UBE4B	Ensembl:ENSG00000130939	euGenes: HUgn10277
ECgene: UBE4B	H-InvDB: UBE4B

(According to HUGE)
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HUGE: KIAA0684

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for UBE4B	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for UBE4B
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UBE4B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE4B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBE4B		Antibodies for UBE4B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UBE4B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for UBE4B

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UBE4B Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for UBE4B

Summaries
for UBE4B

Genomic Location
for UBE4B

Proteins
for UBE4B

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Families
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Gene Function
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Transcripts
for UBE4B

Expression
for UBE4B

Orthologs
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE4B Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor UBE4B

Summariesfor UBE4B

Genomic Locationfor UBE4B

Proteinsfor UBE4B

Protein Domains/Familiesfor UBE4B

Gene Functionfor UBE4B

Pathways & Interactionsfor UBE4B

Drugs & Compoundsfor UBE4B

Transcriptsfor UBE4B

Expression for UBE4B

Orthologsfor UBE4B

Paralogsfor UBE4B

SNPs/Variantsfor UBE4B

Disorders & Mutationsfor UBE4B

Medical Newsfor UBE4B

Publicationsfor UBE4B

Search for UBE4B

Genome Databases showing UBE4B

Other Databases showing UBE4B

Specialized Databases showing UBE4B

Licensable Technologiesfor UBE4B

Servicesfor UBE4B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE4B

Summaries
for UBE4B

Genomic Location
for UBE4B

Proteins
for UBE4B

Protein Domains/
Families
for UBE4B

Gene Function
for UBE4B

Pathways & Interactions
for UBE4B

Drugs & Compounds
for UBE4B

Transcripts
for UBE4B

Expression
for UBE4B

Orthologs
for UBE4B

Paralogs
for UBE4B

SNPs/Variants
for UBE4B

Disorders & Mutations
for UBE4B

Medical News
for UBE4B

Publications
for UBE4B

Licensable Technologies
for UBE4B

Services
for UBE4B